Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.007 0.113 -9999.0 0.0 -9999.0 0.0 0.0 IHH -0.04 0.215 -9999.0 0.0 -0.662 7.0 7.0 SHH Np/Cholesterol/GAS1 -0.115 0.189 -9999.0 0.0 -0.382 22.0 22.0 LRPAP1 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.114 0.188 0.379 22.0 -9999.0 0.0 22.0 SMO/beta Arrestin2 -0.046 0.174 -9999.0 0.0 -0.518 6.0 6.0 SMO -0.062 0.177 -9999.0 0.0 -0.522 7.0 7.0 AKT1 -0.014 0.086 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.03 0.028 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.06 0.174 -9999.0 0.0 -0.514 7.0 7.0 STIL -0.097 0.189 -9999.0 0.0 -0.383 15.0 15.0 DHH N/PTCH2 -0.015 0.147 -9999.0 0.0 -0.478 6.0 6.0 DHH N/PTCH1 -0.038 0.159 -9999.0 0.0 -0.355 13.0 13.0 PIK3CA 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.037 0.19 -9999.0 0.0 -0.637 6.0 6.0 PTHLH -0.018 0.139 -9999.0 0.0 -9999.0 0.0 0.0 determination of left/right symmetry -0.06 0.174 -9999.0 0.0 -0.514 7.0 7.0 PIK3R1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.018 0.138 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/Hhip -0.013 0.142 -9999.0 0.0 -0.423 7.0 7.0 DHH N/Hhip -0.016 0.147 -9999.0 0.0 -0.481 6.0 6.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.06 0.174 -9999.0 0.0 -0.514 7.0 7.0 pancreas development 0.012 0.018 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.025 0.176 -9999.0 0.0 -0.637 5.0 5.0 somite specification -0.06 0.174 -9999.0 0.0 -0.514 7.0 7.0 SHH Np/Cholesterol/PTCH1 -0.102 0.194 -9999.0 0.0 -0.377 20.0 20.0 SHH Np/Cholesterol/PTCH2 -0.086 0.174 -9999.0 0.0 -0.38 17.0 17.0 SHH Np/Cholesterol/Megalin -0.354 0.238 -9999.0 0.0 -0.469 49.0 49.0 SHH -0.133 0.205 -9999.0 0.0 -0.48 17.0 17.0 catabolic process -0.012 0.127 -9999.0 0.0 -0.376 7.0 7.0 SMO/Vitamin D3 -0.114 0.209 -9999.0 0.0 -0.565 6.0 6.0 SHH Np/Cholesterol/Hhip -0.089 0.173 -9999.0 0.0 -0.382 17.0 17.0 LRP2 -0.456 0.288 -9999.0 0.0 -0.631 48.0 48.0 receptor-mediated endocytosis -0.3 0.251 -9999.0 0.0 -0.646 18.0 18.0 SHH Np/Cholesterol/BOC -0.085 0.174 -9999.0 0.0 -0.381 17.0 17.0 SHH Np/Cholesterol/CDO -0.084 0.175 -9999.0 0.0 -0.381 17.0 17.0 mesenchymal cell differentiation 0.089 0.171 0.379 17.0 -9999.0 0.0 17.0 mol:Vitamin D3 -0.094 0.202 -9999.0 0.0 -0.377 20.0 20.0 IHH N/PTCH2 -0.01 0.14 -9999.0 0.0 -0.415 7.0 7.0 CDON 0.024 0.012 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.003 0.132 -9999.0 0.0 -0.38 7.0 7.0 Megalin/LRPAP1 -0.331 0.226 -9999.0 0.0 -0.466 48.0 48.0 PTCH2 0.021 0.008 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.096 0.166 -9999.0 0.0 -0.378 17.0 17.0 PTCH1 -0.012 0.128 -9999.0 0.0 -0.377 7.0 7.0 HHIP 0.012 0.018 -9999.0 0.0 -9999.0 0.0 0.0