E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.021 0.101 -9999.0 0.0 -0.512 21.0 21.0 KLHL20 -0.013 0.046 -9999.0 0.0 -0.351 2.0 2.0 CYFIP2 0.004 0.094 -9999.0 0.0 -0.746 8.0 8.0 Rac1/GDP 0.068 0.076 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.021 0.101 -9999.0 0.0 -0.512 21.0 21.0 AP1M1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.015 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.01 0.046 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.01 0.036 -9999.0 0.0 -0.216 7.0 7.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.017 0.084 -9999.0 0.0 -9999.0 0.0 0.0 RAPGEF1 0.054 0.099 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.022 0.106 -9999.0 0.0 -0.536 21.0 21.0 CRK 0.043 0.106 -9999.0 0.0 -0.471 21.0 21.0 E-cadherin/gamma catenin/alpha catenin -0.022 0.104 -9999.0 0.0 -0.495 23.0 23.0 alphaE/beta7 Integrin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.021 0.101 -9999.0 0.0 -0.512 21.0 21.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.007 0.035 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 -0.001 0.019 -9999.0 0.0 -0.437 1.0 1.0 PI3K -0.01 0.044 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.026 0.121 -9999.0 0.0 -0.58 23.0 23.0 TIAM1 0.014 0.033 -9999.0 0.0 -0.746 1.0 1.0 E-cadherin(dimer)/Ca2+ -0.016 0.08 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.005 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.014 0.033 -9999.0 0.0 -0.746 1.0 1.0 CDH1 -0.016 0.15 -9999.0 0.0 -0.746 21.0 21.0 RhoA/GDP 0.067 0.075 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.01 0.034 -9999.0 0.0 -0.245 2.0 2.0 CDC42/GDP 0.067 0.075 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.014 0.068 -9999.0 0.0 -0.322 23.0 23.0 ITGB7 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.017 0.084 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.017 0.082 -9999.0 0.0 -0.414 21.0 21.0 mol:GDP 0.063 0.086 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.011 0.058 -9999.0 0.0 -0.746 3.0 3.0 p120 catenin/RhoA/GDP -0.012 0.06 -9999.0 0.0 -9999.0 0.0 0.0 RAC1/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.035 0.064 -9999.0 0.0 -0.263 20.0 20.0 NME1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.021 0.101 -9999.0 0.0 -0.512 21.0 21.0 regulation of cell-cell adhesion -0.008 0.041 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.005 0.018 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.011 0.054 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.018 0.087 -9999.0 0.0 -0.81 1.0 1.0 CCND1 -0.016 0.065 -9999.0 0.0 -0.334 20.0 20.0 VAV2 0.049 0.103 -9999.0 0.0 -0.503 1.0 1.0 RAP1/GDP -0.011 0.056 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.033 0.109 -9999.0 0.0 -0.494 21.0 21.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.017 0.081 -9999.0 0.0 -0.773 1.0 1.0 E-cadherin/beta catenin -0.018 0.09 -9999.0 0.0 -0.454 21.0 21.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.021 0.101 -9999.0 0.0 -0.512 21.0 21.0 PIK3CA 0.014 0.033 -9999.0 0.0 -0.746 1.0 1.0 Rac1/GTP -0.02 0.072 -9999.0 0.0 -0.601 1.0 1.0 E-cadherin/beta catenin/alpha catenin -0.019 0.094 -9999.0 0.0 -0.476 21.0 21.0 ITGAE 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.022 0.108 -9999.0 0.0 -0.549 21.0 21.0