Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.249 0.257 -9999.0 0.0 -0.743 32.0 32.0 IHH -0.099 0.233 -9999.0 0.0 -0.821 47.0 47.0 SHH Np/Cholesterol/GAS1 -0.037 0.125 -9999.0 0.0 -0.453 42.0 42.0 LRPAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.036 0.124 0.45 42.0 -9999.0 0.0 42.0 SMO/beta Arrestin2 -0.147 0.152 -9999.0 0.0 -0.599 34.0 34.0 SMO -0.133 0.191 -9999.0 0.0 -0.637 33.0 33.0 AKT1 -0.042 0.093 -9999.0 0.0 -0.465 1.0 1.0 ARRB2 0.014 0.039 -9999.0 0.0 -0.864 1.0 1.0 BOC 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.131 0.188 -9999.0 0.0 -0.625 33.0 33.0 STIL -0.095 0.166 -9999.0 0.0 -0.673 10.0 10.0 DHH N/PTCH2 -0.044 0.162 -9999.0 0.0 -0.634 36.0 36.0 DHH N/PTCH1 -0.16 0.161 -9999.0 0.0 -0.618 36.0 36.0 PIK3CA 0.014 0.033 -9999.0 0.0 -0.746 1.0 1.0 DHH -0.001 0.11 -9999.0 0.0 -0.746 11.0 11.0 PTHLH -0.443 0.407 -9999.0 0.0 -0.742 322.0 322.0 determination of left/right symmetry -0.131 0.188 -9999.0 0.0 -0.625 33.0 33.0 PIK3R1 0.014 0.033 -9999.0 0.0 -0.746 1.0 1.0 skeletal system development -0.438 0.402 -9999.0 0.0 -0.734 322.0 322.0 IHH N/Hhip -0.203 0.31 -9999.0 0.0 -0.653 160.0 160.0 DHH N/Hhip -0.153 0.256 -9999.0 0.0 -0.575 138.0 138.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.131 0.188 -9999.0 0.0 -0.625 33.0 33.0 pancreas development -0.177 0.333 -9999.0 0.0 -0.754 129.0 129.0 HHAT 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.002 0.035 -9999.0 0.0 -0.56 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.032 0.184 -9999.0 0.0 -0.75 32.0 32.0 somite specification -0.131 0.188 -9999.0 0.0 -0.625 33.0 33.0 SHH Np/Cholesterol/PTCH1 -0.135 0.143 -9999.0 0.0 -0.554 36.0 36.0 SHH Np/Cholesterol/PTCH2 -0.035 0.129 -9999.0 0.0 -0.506 36.0 36.0 SHH Np/Cholesterol/Megalin -0.048 0.15 -9999.0 0.0 -0.485 51.0 51.0 SHH 0.018 0.087 -9999.0 0.0 -0.57 11.0 11.0 catabolic process -0.156 0.194 -9999.0 0.0 -0.653 32.0 32.0 SMO/Vitamin D3 -0.112 0.178 -9999.0 0.0 -0.579 36.0 36.0 SHH Np/Cholesterol/Hhip -0.12 0.207 -9999.0 0.0 -0.461 135.0 135.0 LRP2 -0.051 0.215 -9999.0 0.0 -0.749 45.0 45.0 receptor-mediated endocytosis -0.154 0.178 -9999.0 0.0 -0.618 44.0 44.0 SHH Np/Cholesterol/BOC -0.009 0.064 -9999.0 0.0 -0.446 11.0 11.0 SHH Np/Cholesterol/CDO -0.07 0.181 -9999.0 0.0 -0.527 69.0 69.0 mesenchymal cell differentiation 0.119 0.206 0.458 135.0 -9999.0 0.0 135.0 mol:Vitamin D3 -0.109 0.172 -9999.0 0.0 -0.56 36.0 36.0 IHH N/PTCH2 -0.084 0.217 -9999.0 0.0 -0.618 70.0 70.0 CDON -0.084 0.279 -9999.0 0.0 -0.864 59.0 59.0 IHH N/PTCH1 -0.158 0.195 -9999.0 0.0 -0.663 32.0 32.0 Megalin/LRPAP1 -0.049 0.158 -9999.0 0.0 -0.562 45.0 45.0 PTCH2 -0.027 0.189 -9999.0 0.0 -0.864 25.0 25.0 SHH Np/Cholesterol -0.01 0.066 -9999.0 0.0 -0.457 11.0 11.0 PTCH1 -0.157 0.194 -9999.0 0.0 -0.655 32.0 32.0 HHIP -0.177 0.333 -9999.0 0.0 -0.755 129.0 129.0