Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.012 0.058 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation -0.016 0.079 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.004 0.094 -9999.0 0.0 -0.746 8.0 8.0 ENAH 0.079 0.065 -9999.0 0.0 -9999.0 0.0 0.0 EGFR 0.001 0.113 -9999.0 0.0 -0.851 9.0 9.0 EPHA2 0.014 0.033 -9999.0 0.0 -0.746 1.0 1.0 MYO6 0.032 0.097 -9999.0 0.0 -0.781 2.0 2.0 CTNNB1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.007 0.059 -9999.0 0.0 -0.476 8.0 8.0 AQP5 -0.171 0.245 -9999.0 0.0 -0.525 159.0 159.0 CTNND1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.035 0.083 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.018 0.123 -9999.0 0.0 -0.839 1.0 1.0 EGF -0.67 0.229 -9999.0 0.0 -0.746 466.0 466.0 NCKAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.051 0.16 -9999.0 0.0 -0.574 38.0 38.0 cortical microtubule organization -0.016 0.079 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.035 0.079 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.016 0.08 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.014 0.063 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.003 0.035 -9999.0 0.0 -0.523 1.0 1.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.051 0.084 -9999.0 0.0 -0.578 1.0 1.0 PVRL2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.035 0.084 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP -0.002 0.032 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.015 0.15 -9999.0 0.0 -0.746 21.0 21.0 EGFR/EGFR/EGF/EGF -0.346 0.145 -9999.0 0.0 -0.774 27.0 27.0 RhoA/GDP -0.015 0.073 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.042 0.092 -9999.0 0.0 -0.715 2.0 2.0 IGF-1R heterotetramer 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.006 0.094 -9999.0 0.0 -0.864 6.0 6.0 DIAPH1 -0.01 0.086 -9999.0 0.0 -0.696 8.0 8.0 Wnt receptor signaling pathway 0.016 0.079 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.014 0.063 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.042 0.094 -9999.0 0.0 -0.744 2.0 2.0 EFNA1 0.014 0.039 -9999.0 0.0 -0.864 1.0 1.0 LPP 0.044 0.089 -9999.0 0.0 -0.805 1.0 1.0 Ephrin A1/EPHA2 -0.016 0.074 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 -0.013 0.062 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.018 0.125 -9999.0 0.0 -0.866 1.0 1.0 HGF/MET -0.037 0.131 -9999.0 0.0 -0.955 4.0 4.0 HGF -0.021 0.169 -9999.0 0.0 -0.802 23.0 23.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.012 0.059 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.099 0.07 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.037 0.124 -9999.0 0.0 -0.857 6.0 6.0 KIFC3 0.034 0.086 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.014 0.033 -9999.0 0.0 -0.746 1.0 1.0 EXOC3 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.033 0.093 -9999.0 0.0 -0.866 1.0 1.0 NCK1/GIT1 -0.001 0.025 -9999.0 0.0 -0.56 1.0 1.0 mol:GDP -0.016 0.079 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.035 0.084 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.035 0.084 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.012 0.055 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.059 0.123 -9999.0 0.0 -0.79 7.0 7.0 IGF-1R heterotetramer/IGF1 -0.02 0.084 -9999.0 0.0 -9999.0 0.0 0.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.007 0.086 -9999.0 0.0 -0.864 5.0 5.0 PLEKHA7 0.032 0.101 -9999.0 0.0 -0.781 3.0 3.0 mol:GTP -0.003 0.035 -9999.0 0.0 -0.518 1.0 1.0 establishment of epithelial cell apical/basal polarity 0.071 0.076 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.012 0.058 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion 0.042 0.092 -9999.0 0.0 -0.715 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.012 0.059 -9999.0 0.0 -9999.0 0.0 0.0