E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.025 0.123 -9999.0 0.0 -0.471 16.0 16.0 KLHL20 0.016 0.073 0.202 2.0 -0.305 2.0 4.0 CYFIP2 0.013 0.075 -9999.0 0.0 -0.611 7.0 7.0 Rac1/GDP 0.018 0.086 0.286 6.0 -0.351 1.0 7.0 ENAH -0.024 0.122 -9999.0 0.0 -0.472 17.0 17.0 AP1M1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.021 0.013 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.023 0.052 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.013 0.034 -9999.0 0.0 -0.197 4.0 4.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.036 0.078 -9999.0 0.0 -0.349 16.0 16.0 RAPGEF1 -0.017 0.12 0.269 4.0 -0.425 11.0 15.0 CTNND1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.025 0.128 -9999.0 0.0 -0.486 17.0 17.0 CRK -0.026 0.123 -9999.0 0.0 -0.443 14.0 14.0 E-cadherin/gamma catenin/alpha catenin 0.028 0.084 -9999.0 0.0 -0.409 15.0 15.0 alphaE/beta7 Integrin 0.041 0.01 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.049 0.019 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.021 0.118 -9999.0 0.0 -0.471 15.0 15.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.006 0.028 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.049 0.019 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.005 0.041 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.022 0.097 -9999.0 0.0 -0.472 18.0 18.0 TIAM1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.03 0.069 -9999.0 0.0 -0.329 13.0 13.0 AKT1 0.016 0.03 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.025 0.029 -9999.0 0.0 -0.611 1.0 1.0 CDH1 0.007 0.112 -9999.0 0.0 -0.593 17.0 17.0 RhoA/GDP 0.036 0.083 0.328 10.0 -9999.0 0.0 10.0 actin cytoskeleton organization 0.018 0.061 0.169 14.0 -0.216 2.0 16.0 CDC42/GDP 0.026 0.107 0.366 15.0 -0.346 1.0 16.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.01 0.061 -9999.0 0.0 -0.298 15.0 15.0 ITGB7 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.033 0.074 -9999.0 0.0 -0.348 13.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.02 0.064 -9999.0 0.0 -0.33 13.0 13.0 mol:GDP 0.014 0.114 0.408 12.0 -0.395 3.0 15.0 CDC42/GTP/IQGAP1 0.037 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.024 0.049 -9999.0 0.0 -0.611 3.0 3.0 p120 catenin/RhoA/GDP 0.014 0.08 0.303 3.0 -9999.0 0.0 3.0 RAC1/GTP/IQGAP1 0.035 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.042 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.021 0.013 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.022 0.012 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.017 0.059 0.164 16.0 -0.197 18.0 34.0 NME1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.025 0.123 -9999.0 0.0 -0.476 16.0 16.0 regulation of cell-cell adhesion 0.01 0.04 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.012 0.03 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.03 0.064 0.249 5.0 -9999.0 0.0 5.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.048 0.083 -9999.0 0.0 -0.632 1.0 1.0 CCND1 0.017 0.069 0.179 12.0 -0.245 18.0 30.0 VAV2 -0.023 0.161 -9999.0 0.0 -0.566 17.0 17.0 RAP1/GDP 0.037 0.075 0.273 6.0 -9999.0 0.0 6.0 adherens junction assembly -0.024 0.12 -9999.0 0.0 -0.461 16.0 16.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.045 0.087 -9999.0 0.0 -0.609 1.0 1.0 E-cadherin/beta catenin -0.001 0.075 -9999.0 0.0 -0.398 17.0 17.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.024 0.121 -9999.0 0.0 -0.467 16.0 16.0 PIK3CA 0.026 0.029 -9999.0 0.0 -0.611 1.0 1.0 Rac1/GTP -0.033 0.077 -9999.0 0.0 -0.376 5.0 5.0 E-cadherin/beta catenin/alpha catenin 0.023 0.074 -9999.0 0.0 -0.383 13.0 13.0 ITGAE 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.026 0.131 -9999.0 0.0 -0.497 17.0 17.0