Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.156 0.171 -9999.0 0.0 -0.549 27.0 27.0 IHH -0.075 0.185 -9999.0 0.0 -0.653 44.0 44.0 SHH Np/Cholesterol/GAS1 0.003 0.093 -9999.0 0.0 -0.354 29.0 29.0 LRPAP1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.003 0.092 0.352 29.0 -9999.0 0.0 29.0 SMO/beta Arrestin2 -0.076 0.139 -9999.0 0.0 -0.491 26.0 26.0 SMO -0.086 0.138 -9999.0 0.0 -0.513 25.0 25.0 AKT1 -0.034 0.11 -9999.0 0.0 -0.49 15.0 15.0 ARRB2 0.027 0.029 -9999.0 0.0 -0.621 1.0 1.0 BOC 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.085 0.136 -9999.0 0.0 -0.505 25.0 25.0 STIL -0.062 0.125 -9999.0 0.0 -0.402 27.0 27.0 DHH N/PTCH2 0.01 0.11 -9999.0 0.0 -0.388 35.0 35.0 DHH N/PTCH1 -0.094 0.14 -9999.0 0.0 -0.471 31.0 31.0 PIK3CA 0.026 0.029 -9999.0 0.0 -0.611 1.0 1.0 DHH 0.014 0.093 -9999.0 0.0 -0.611 11.0 11.0 PTHLH -0.237 0.235 -9999.0 0.0 -0.736 35.0 35.0 determination of left/right symmetry -0.085 0.136 -9999.0 0.0 -0.505 25.0 25.0 PIK3R1 0.025 0.029 -9999.0 0.0 -0.611 1.0 1.0 skeletal system development -0.236 0.233 -9999.0 0.0 -0.729 35.0 35.0 IHH N/Hhip -0.153 0.24 -9999.0 0.0 -0.503 153.0 153.0 DHH N/Hhip -0.087 0.215 -9999.0 0.0 -0.451 129.0 129.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.085 0.136 -9999.0 0.0 -0.505 25.0 25.0 pancreas development -0.125 0.269 -9999.0 0.0 -0.592 126.0 126.0 HHAT 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.036 0.034 -9999.0 0.0 -0.452 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.008 0.143 -9999.0 0.0 -0.558 31.0 31.0 somite specification -0.085 0.136 -9999.0 0.0 -0.505 25.0 25.0 SHH Np/Cholesterol/PTCH1 -0.074 0.118 -9999.0 0.0 -0.415 27.0 27.0 SHH Np/Cholesterol/PTCH2 0.008 0.08 -9999.0 0.0 -0.299 31.0 31.0 SHH Np/Cholesterol/Megalin -0.004 0.111 -9999.0 0.0 -0.387 35.0 35.0 SHH 0.009 0.066 -9999.0 0.0 -0.449 10.0 10.0 catabolic process -0.109 0.143 -9999.0 0.0 -0.482 32.0 32.0 SMO/Vitamin D3 -0.076 0.129 -9999.0 0.0 -0.46 27.0 27.0 SHH Np/Cholesterol/Hhip -0.064 0.166 -9999.0 0.0 -0.362 112.0 112.0 LRP2 -0.021 0.166 -9999.0 0.0 -0.564 42.0 42.0 receptor-mediated endocytosis -0.089 0.153 -9999.0 0.0 -0.618 17.0 17.0 SHH Np/Cholesterol/BOC 0.02 0.054 -9999.0 0.0 -0.348 10.0 10.0 SHH Np/Cholesterol/CDO -0.011 0.104 -9999.0 0.0 -0.289 60.0 60.0 mesenchymal cell differentiation 0.064 0.164 0.36 112.0 -9999.0 0.0 112.0 mol:Vitamin D3 -0.069 0.127 -9999.0 0.0 -0.418 27.0 27.0 IHH N/PTCH2 -0.053 0.149 -9999.0 0.0 -0.419 67.0 67.0 CDON -0.032 0.169 -9999.0 0.0 -0.504 58.0 58.0 IHH N/PTCH1 -0.109 0.145 -9999.0 0.0 -0.488 32.0 32.0 Megalin/LRPAP1 0.004 0.125 -9999.0 0.0 -0.448 34.0 34.0 PTCH2 0.002 0.115 -9999.0 0.0 -0.504 25.0 25.0 SHH Np/Cholesterol 0.01 0.052 -9999.0 0.0 -0.351 10.0 10.0 PTCH1 -0.11 0.143 -9999.0 0.0 -0.484 32.0 32.0 HHIP -0.126 0.269 -9999.0 0.0 -0.592 126.0 126.0