Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.011 0.055 -9999.0 0.0 -0.292 13.0 13.0 epithelial cell differentiation 0.027 0.067 -9999.0 0.0 -0.325 13.0 13.0 CYFIP2 0.013 0.075 -9999.0 0.0 -0.611 7.0 7.0 ENAH 0.056 0.101 0.383 17.0 -9999.0 0.0 17.0 EGFR 0.019 0.06 -9999.0 0.0 -0.522 6.0 6.0 EPHA2 0.026 0.029 -9999.0 0.0 -0.611 1.0 1.0 MYO6 0.055 0.108 0.381 13.0 -0.449 2.0 15.0 CTNNB1 0.02 0.013 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.036 0.056 -9999.0 0.0 -0.384 7.0 7.0 AQP5 -0.109 0.235 -9999.0 0.0 -0.505 108.0 108.0 CTNND1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.059 0.106 0.393 13.0 -9999.0 0.0 13.0 regulation of calcium-dependent cell-cell adhesion 0.05 0.113 0.403 11.0 -0.391 1.0 12.0 EGF -0.544 0.192 -9999.0 0.0 -0.606 460.0 460.0 NCKAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 0.004 0.153 -9999.0 0.0 -0.53 29.0 29.0 cortical microtubule organization 0.027 0.067 -9999.0 0.0 -0.325 13.0 13.0 GO:0000145 0.049 0.105 0.386 13.0 -9999.0 0.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.03 0.069 -9999.0 0.0 -0.329 13.0 13.0 MLLT4 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.008 0.044 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.062 0.039 -9999.0 0.0 -0.352 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.037 0.081 0.37 2.0 -9999.0 0.0 2.0 PVRL2 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.045 0.092 0.358 5.0 -9999.0 0.0 5.0 ARF6/GTP 0.066 0.042 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.007 0.112 -9999.0 0.0 -0.593 17.0 17.0 EGFR/EGFR/EGF/EGF -0.229 0.138 -9999.0 0.0 -0.549 18.0 18.0 RhoA/GDP 0.028 0.064 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.047 0.101 0.343 12.0 -0.423 2.0 14.0 IGF-1R heterotetramer 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.023 0.053 -9999.0 0.0 -0.504 5.0 5.0 DIAPH1 0.029 0.108 -9999.0 0.0 -0.662 7.0 7.0 Wnt receptor signaling pathway -0.027 0.067 0.325 13.0 -9999.0 0.0 13.0 RHOA 0.021 0.013 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.008 0.045 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.022 0.012 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.048 0.102 0.346 12.0 -0.434 2.0 14.0 EFNA1 0.026 0.024 -9999.0 0.0 -0.504 1.0 1.0 LPP 0.043 0.092 0.387 6.0 -9999.0 0.0 6.0 Ephrin A1/EPHA2 0.022 0.061 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 0.001 0.047 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.05 0.114 0.406 11.0 -0.398 1.0 12.0 HGF/MET 0.013 0.083 -9999.0 0.0 -0.518 3.0 3.0 HGF 0.003 0.112 -9999.0 0.0 -0.542 20.0 20.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.011 0.056 -9999.0 0.0 -0.294 13.0 13.0 actin cable formation 0.098 0.13 0.325 72.0 -9999.0 0.0 72.0 KIAA1543 0.045 0.104 0.352 10.0 -0.503 2.0 12.0 KIFC3 0.048 0.092 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.026 0.029 -9999.0 0.0 -0.611 1.0 1.0 EXOC3 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.05 0.099 0.429 7.0 -9999.0 0.0 7.0 NCK1/GIT1 0.039 0.025 -9999.0 0.0 -0.452 1.0 1.0 mol:GDP 0.027 0.067 -9999.0 0.0 -0.325 13.0 13.0 EXOC4 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.048 0.09 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.059 0.107 0.396 13.0 -9999.0 0.0 13.0 LIMA1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.068 0.111 0.399 20.0 -9999.0 0.0 20.0 adherens junction assembly 0.067 0.135 0.505 16.0 -0.695 2.0 18.0 IGF-1R heterotetramer/IGF1 0.022 0.064 -9999.0 0.0 -9999.0 0.0 0.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.039 0.013 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.024 0.034 -9999.0 0.0 -0.504 2.0 2.0 PLEKHA7 0.055 0.105 0.36 10.0 -0.529 2.0 12.0 mol:GTP 0.06 0.038 -9999.0 0.0 -0.35 2.0 2.0 establishment of epithelial cell apical/basal polarity 0.077 0.126 0.373 49.0 -9999.0 0.0 49.0 cortical actin cytoskeleton stabilization 0.011 0.055 -9999.0 0.0 -0.292 13.0 13.0 regulation of cell-cell adhesion 0.047 0.101 0.343 12.0 -0.423 2.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.011 0.056 -9999.0 0.0 -0.294 13.0 13.0