Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	243.0	8265.0	34.0	-0.493	0.029	1000.0	-1000.0	-0.048	-1000.0
HIF-1-alpha transcription factor network	159.0	12102.0	76.0	-0.994	0.044	1000.0	-1000.0	-0.156	-1000.0
EGFR-dependent Endothelin signaling events	140.0	2945.0	21.0	-0.544	0.041	1000.0	-1000.0	-0.053	-1000.0
TCR signaling in naïve CD8+ T cells	134.0	12522.0	93.0	-0.412	0.191	1000.0	-1000.0	-0.065	-1000.0
FOXA2 and FOXA3 transcription factor networks	131.0	6026.0	46.0	-1.067	0.034	1000.0	-1000.0	-0.104	-1000.0
PDGFR-alpha signaling pathway	111.0	4909.0	44.0	-0.214	0.035	1000.0	-1000.0	-0.05	-1000.0
TCGA08_retinoblastoma	98.0	787.0	8.0	-0.496	0.133	1000.0	-1000.0	-0.006	-1000.0
Syndecan-4-mediated signaling events	91.0	6156.0	67.0	-0.373	0.083	1000.0	-1000.0	-0.05	-1000.0
TCGA08_p53	89.0	629.0	7.0	-0.353	0.19	1000.0	-1000.0	-0.012	-1000.0
Glypican 1 network	82.0	3948.0	48.0	-0.382	0.045	1000.0	-1000.0	-0.047	-1000.0
Aurora B signaling	81.0	5428.0	67.0	-0.229	0.04	1000.0	-1000.0	-0.055	-1000.0
IL12-mediated signaling events	79.0	6921.0	87.0	-0.384	0.097	1000.0	-1000.0	-0.111	-1000.0
amb2 Integrin signaling	73.0	5993.0	82.0	-0.434	0.037	1000.0	-1000.0	-0.047	-1000.0
BMP receptor signaling	71.0	5798.0	81.0	-0.505	0.052	1000.0	-1000.0	-0.081	-1000.0
Aurora C signaling	68.0	476.0	7.0	-0.222	0.026	1000.0	-1000.0	-0.015	-1000.0
Glypican 2 network	61.0	244.0	4.0	-0.03	-1000.0	1000.0	-1000.0	-0.004	-1000.0
FOXM1 transcription factor network	60.0	3088.0	51.0	-0.483	0.029	1000.0	-1000.0	-0.114	-1000.0
JNK signaling in the CD4+ TCR pathway	56.0	955.0	17.0	-0.188	0.028	1000.0	-1000.0	-0.046	-1000.0
Caspase cascade in apoptosis	52.0	3890.0	74.0	-0.286	0.073	1000.0	-1000.0	-0.046	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	50.0	1670.0	33.0	-0.489	0.053	1000.0	-1000.0	-0.042	-1000.0
IL4-mediated signaling events	49.0	4528.0	91.0	-0.769	0.467	1000.0	-1000.0	-0.127	-1000.0
Syndecan-1-mediated signaling events	45.0	1539.0	34.0	-0.212	0.029	1000.0	-1000.0	-0.063	-1000.0
Fc-epsilon receptor I signaling in mast cells	41.0	4000.0	97.0	-0.238	0.039	1000.0	-1000.0	-0.076	-1000.0
Arf6 signaling events	39.0	2418.0	62.0	-0.544	0.062	1000.0	-1000.0	-0.044	-1000.0
Effects of Botulinum toxin	38.0	1001.0	26.0	-0.2	0.04	1000.0	-1000.0	-0.027	-1000.0
HIF-2-alpha transcription factor network	37.0	1608.0	43.0	-0.453	0.208	1000.0	-1000.0	-0.066	-1000.0
Calcium signaling in the CD4+ TCR pathway	37.0	1152.0	31.0	-0.332	0.028	1000.0	-1000.0	-0.055	-1000.0
Reelin signaling pathway	36.0	2030.0	56.0	-0.165	0.077	1000.0	-1000.0	-0.068	-1000.0
Signaling events mediated by the Hedgehog family	35.0	1839.0	52.0	-0.237	0.064	1000.0	-1000.0	-0.056	-1000.0
LPA4-mediated signaling events	33.0	396.0	12.0	-0.085	0.009	1000.0	-1000.0	-0.028	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	33.0	1815.0	54.0	-0.381	0.04	1000.0	-1000.0	-0.079	-1000.0
IL27-mediated signaling events	32.0	1666.0	51.0	-0.59	0.048	1000.0	-1000.0	-0.058	-1000.0
Ephrin A  reverse signaling	31.0	217.0	7.0	-0.022	0.013	1000.0	-1000.0	-0.013	-1000.0
IL2 signaling events mediated by STAT5	30.0	681.0	22.0	-0.253	0.034	1000.0	-1000.0	-0.061	-1000.0
Coregulation of Androgen receptor activity	29.0	2277.0	76.0	-0.835	0.052	1000.0	-1000.0	-0.028	-1000.0
p75(NTR)-mediated signaling	29.0	3695.0	125.0	-0.293	0.076	1000.0	-1000.0	-0.083	-1000.0
PLK1 signaling events	29.0	2545.0	85.0	-0.16	0.041	1000.0	-1000.0	-0.054	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	29.0	2008.0	68.0	-0.277	0.052	1000.0	-1000.0	-0.107	-1000.0
S1P1 pathway	28.0	1043.0	36.0	-0.21	0.028	1000.0	-1000.0	-0.057	-1000.0
Glucocorticoid receptor regulatory network	24.0	2788.0	114.0	-0.329	0.137	1000.0	-1000.0	-0.068	-1000.0
Ceramide signaling pathway	24.0	1830.0	76.0	-0.544	0.202	1000.0	-1000.0	-0.046	-1000.0
VEGFR1 specific signals	24.0	1399.0	56.0	-0.27	0.029	1000.0	-1000.0	-0.06	-1000.0
Integrins in angiogenesis	23.0	1956.0	84.0	-0.254	0.065	1000.0	-1000.0	-0.074	-1000.0
BCR signaling pathway	23.0	2327.0	99.0	-0.188	0.056	1000.0	-1000.0	-0.073	-1000.0
IL23-mediated signaling events	23.0	1419.0	60.0	-0.216	0.028	1000.0	-1000.0	-0.085	-1000.0
Signaling events mediated by PTP1B	22.0	1688.0	76.0	-0.545	0.067	1000.0	-1000.0	-0.058	-1000.0
IL2 signaling events mediated by PI3K	22.0	1309.0	58.0	-0.251	0.045	1000.0	-1000.0	-0.058	-1000.0
Wnt signaling	22.0	158.0	7.0	-0.042	0.027	1000.0	-1000.0	-0.036	-1000.0
Noncanonical Wnt signaling pathway	21.0	546.0	26.0	-0.096	0.028	1000.0	-1000.0	-0.06	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	21.0	968.0	45.0	-0.31	0.075	1000.0	-1000.0	-0.067	-1000.0
Regulation of Telomerase	21.0	2164.0	102.0	-0.544	0.059	1000.0	-1000.0	-0.075	-1000.0
Angiopoietin receptor Tie2-mediated signaling	21.0	1901.0	88.0	-0.171	0.037	1000.0	-1000.0	-0.084	-1000.0
FoxO family signaling	20.0	1327.0	64.0	-0.554	0.086	1000.0	-1000.0	-0.062	-1000.0
Visual signal transduction: Rods	20.0	1046.0	52.0	-0.133	0.041	1000.0	-1000.0	-0.064	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	20.0	1610.0	78.0	-0.23	0.043	1000.0	-1000.0	-0.063	-1000.0
Thromboxane A2 receptor signaling	19.0	2011.0	105.0	-0.544	0.04	1000.0	-1000.0	-0.052	-1000.0
Syndecan-2-mediated signaling events	18.0	1302.0	69.0	-0.434	0.061	1000.0	-1000.0	-0.046	-1000.0
EPO signaling pathway	18.0	1041.0	55.0	-0.141	0.035	1000.0	-1000.0	-0.066	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	18.0	2183.0	120.0	-0.107	0.078	1000.0	-1000.0	-0.063	-1000.0
Signaling mediated by p38-alpha and p38-beta	17.0	774.0	44.0	-0.041	0.05	1000.0	-1000.0	-0.036	-1000.0
Endothelins	16.0	1617.0	96.0	-0.328	0.042	1000.0	-1000.0	-0.067	-1000.0
LPA receptor mediated events	16.0	1662.0	102.0	-0.212	0.046	1000.0	-1000.0	-0.065	-1000.0
Presenilin action in Notch and Wnt signaling	15.0	964.0	61.0	-0.134	0.082	1000.0	-1000.0	-0.069	-1000.0
IFN-gamma pathway	15.0	1040.0	68.0	-0.21	0.041	1000.0	-1000.0	-0.072	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	15.0	1154.0	74.0	-0.544	0.098	1000.0	-1000.0	-0.091	-1000.0
Signaling events regulated by Ret tyrosine kinase	14.0	1174.0	82.0	-0.037	0.029	1000.0	-1000.0	-0.08	-1000.0
IL6-mediated signaling events	14.0	1097.0	75.0	-0.204	0.053	1000.0	-1000.0	-0.058	-1000.0
Class I PI3K signaling events	14.0	1059.0	73.0	-0.26	0.078	1000.0	-1000.0	-0.054	-1000.0
Canonical Wnt signaling pathway	13.0	675.0	51.0	-0.134	0.094	1000.0	-1000.0	-0.06	-1000.0
Nongenotropic Androgen signaling	13.0	724.0	52.0	-0.095	0.043	1000.0	-1000.0	-0.044	-1000.0
Regulation of Androgen receptor activity	13.0	949.0	70.0	-0.909	0.052	1000.0	-1000.0	-0.051	-1000.0
Regulation of nuclear SMAD2/3 signaling	12.0	1719.0	136.0	-0.275	0.096	1000.0	-1000.0	-0.059	-1000.0
PLK2 and PLK4 events	12.0	36.0	3.0	0.006	0.025	1000.0	-1000.0	-0.015	-1000.0
Aurora A signaling	12.0	738.0	60.0	-0.127	0.058	1000.0	-1000.0	-0.034	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	12.0	461.0	37.0	-0.145	0.057	1000.0	-1000.0	-0.037	-1000.0
S1P5 pathway	12.0	211.0	17.0	-0.062	0.028	1000.0	-1000.0	-0.029	-1000.0
Plasma membrane estrogen receptor signaling	12.0	1108.0	86.0	-0.13	0.052	1000.0	-1000.0	-0.08	-1000.0
S1P3 pathway	12.0	524.0	42.0	-0.208	0.049	1000.0	-1000.0	-0.043	-1000.0
ErbB4 signaling events	11.0	762.0	69.0	-0.157	0.096	1000.0	-1000.0	-0.059	-1000.0
FAS signaling pathway (CD95)	11.0	555.0	47.0	-0.242	0.047	1000.0	-1000.0	-0.045	-1000.0
TCGA08_rtk_signaling	11.0	307.0	26.0	-0.216	0.053	1000.0	-1000.0	-0.025	-1000.0
ceramide signaling pathway	10.0	509.0	49.0	-0.054	0.044	1000.0	-1000.0	-0.05	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	10.0	1253.0	125.0	-0.208	0.041	1000.0	-1000.0	-0.067	-1000.0
S1P4 pathway	10.0	266.0	25.0	-0.062	0.037	1000.0	-1000.0	-0.04	-1000.0
E-cadherin signaling events	10.0	54.0	5.0	0.007	0.024	1000.0	-1000.0	-0.003	-1000.0
Sphingosine 1-phosphate (S1P) pathway	9.0	274.0	28.0	-0.062	0.047	1000.0	-1000.0	-0.033	-1000.0
a4b1 and a4b7 Integrin signaling	9.0	45.0	5.0	0.012	0.028	1000.0	-1000.0	0.0	-1000.0
Visual signal transduction: Cones	8.0	332.0	38.0	-0.012	0.044	1000.0	-1000.0	-0.019	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	8.0	733.0	85.0	-0.04	0.076	1000.0	-1000.0	-0.057	-1000.0
mTOR signaling pathway	8.0	431.0	53.0	-0.059	0.05	1000.0	-1000.0	-0.054	-1000.0
Syndecan-3-mediated signaling events	8.0	302.0	35.0	-0.009	0.076	1000.0	-1000.0	-0.05	-1000.0
E-cadherin signaling in keratinocytes	8.0	382.0	43.0	-0.208	0.038	1000.0	-1000.0	-0.058	-1000.0
Ephrin B reverse signaling	7.0	341.0	48.0	-0.047	0.052	1000.0	-1000.0	-0.043	-1000.0
Canonical NF-kappaB pathway	6.0	267.0	39.0	-0.098	0.055	1000.0	-1000.0	-0.049	-1000.0
IL1-mediated signaling events	6.0	373.0	62.0	-0.036	0.062	1000.0	-1000.0	-0.075	-1000.0
E-cadherin signaling in the nascent adherens junction	6.0	495.0	76.0	-0.033	0.049	1000.0	-1000.0	-0.08	-1000.0
Signaling events mediated by PRL	6.0	233.0	34.0	-0.037	0.06	1000.0	-1000.0	-0.051	-1000.0
ErbB2/ErbB3 signaling events	5.0	355.0	65.0	-0.112	0.04	1000.0	-1000.0	-0.057	-1000.0
Cellular roles of Anthrax toxin	5.0	214.0	39.0	-0.009	0.037	1000.0	-1000.0	-0.029	-1000.0
Insulin-mediated glucose transport	5.0	171.0	32.0	-0.036	0.054	1000.0	-1000.0	-0.035	-1000.0
Signaling events mediated by HDAC Class III	5.0	218.0	40.0	-0.052	0.052	1000.0	-1000.0	-0.026	-1000.0
EPHB forward signaling	5.0	443.0	85.0	-0.046	0.069	1000.0	-1000.0	-0.086	-1000.0
Regulation of p38-alpha and p38-beta	5.0	278.0	54.0	-0.021	0.064	1000.0	-1000.0	-0.056	-1000.0
Arf6 trafficking events	5.0	382.0	71.0	-0.114	0.059	1000.0	-1000.0	-0.05	-1000.0
PDGFR-beta signaling pathway	5.0	520.0	97.0	-0.012	0.081	1000.0	-1000.0	-0.073	-1000.0
Class IB PI3K non-lipid kinase events	5.0	15.0	3.0	-0.023	0.023	1000.0	-1000.0	-0.008	-1000.0
p38 MAPK signaling pathway	5.0	251.0	44.0	-0.062	0.055	1000.0	-1000.0	-0.043	-1000.0
Ras signaling in the CD4+ TCR pathway	5.0	100.0	17.0	-0.006	0.052	1000.0	-1000.0	-0.037	-1000.0
Signaling mediated by p38-gamma and p38-delta	4.0	70.0	15.0	-0.0	0.03	1000.0	-1000.0	-0.032	-1000.0
IGF1 pathway	4.0	233.0	57.0	-0.054	0.075	1000.0	-1000.0	-0.064	-1000.0
Insulin Pathway	4.0	298.0	74.0	-0.033	0.077	1000.0	-1000.0	-0.066	-1000.0
BARD1 signaling events	3.0	208.0	57.0	-0.081	0.073	1000.0	-1000.0	-0.075	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	249.0	65.0	-0.005	0.097	1000.0	-1000.0	-0.056	-1000.0
Class I PI3K signaling events mediated by Akt	3.0	228.0	68.0	-0.036	0.053	1000.0	-1000.0	-0.049	-1000.0
Nectin adhesion pathway	3.0	191.0	63.0	-0.0	0.056	1000.0	-1000.0	-0.062	-1000.0
Osteopontin-mediated events	2.0	105.0	38.0	-0.0	0.08	1000.0	-1000.0	-0.055	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	149.0	52.0	-0.013	0.094	1000.0	-1000.0	-0.046	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	240.0	83.0	-0.036	0.068	1000.0	-1000.0	-0.057	-1000.0
Retinoic acid receptors-mediated signaling	2.0	129.0	58.0	-0.021	0.051	1000.0	-1000.0	-0.056	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	76.0	36.0	-0.051	0.053	1000.0	-1000.0	-0.044	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	38.0	23.0	-0.029	0.054	1000.0	-1000.0	-0.042	-1000.0
Signaling events mediated by HDAC Class II	1.0	109.0	75.0	-0.038	0.059	1000.0	-1000.0	-0.034	-1000.0
Circadian rhythm pathway	1.0	24.0	22.0	-0.012	0.065	1000.0	-1000.0	-0.036	-1000.0
Arf6 downstream pathway	1.0	83.0	43.0	-0.045	0.046	1000.0	-1000.0	-0.043	-1000.0
Signaling events mediated by HDAC Class I	1.0	192.0	104.0	-0.055	0.073	1000.0	-1000.0	-0.046	-1000.0
Atypical NF-kappaB pathway	1.0	61.0	31.0	-0.0	0.036	1000.0	-1000.0	-0.035	-1000.0
Arf1 pathway	1.0	84.0	54.0	-0.0	0.047	1000.0	-1000.0	-0.027	-1000.0
TRAIL signaling pathway	0.0	34.0	48.0	-0.0	0.07	1000.0	-1000.0	-0.048	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	7.0	27.0	-0.0	0.067	1000.0	-1000.0	-0.046	-1000.0
Rapid glucocorticoid signaling	0.0	9.0	20.0	-0.007	0.035	1000.0	-1000.0	-0.012	-1000.0
Alternative NF-kappaB pathway	0.0	10.0	13.0	0.0	0.059	1000.0	-1000.0	-0.003	-1000.0
Total	3530	191557	7203	-27.3544814226	-992.0404074	131000	-131000	-7.00075966079	-131000