This pipeline computes the correlation between cancer subtypes identified by different molecular patterns and selected clinical features.
Testing the association between subtypes identified by 8 different clustering approaches and 11 clinical features across 202 patients, 18 significant findings detected with P value < 0.05 and Q value < 0.25.
-
3 subtypes identified in current cancer cohort by 'Copy Number Ratio CNMF subtypes'. These subtypes correlate to 'NEOPLASM.DISEASESTAGE', 'PATHOLOGY.T.STAGE', and 'GENDER'.
-
3 subtypes identified in current cancer cohort by 'METHLYATION CNMF'. These subtypes correlate to 'Time to Death', 'NEOPLASM.DISEASESTAGE', 'PATHOLOGY.T.STAGE', 'PATHOLOGY.N.STAGE', and 'PATHOLOGY.M.STAGE'.
-
CNMF clustering analysis on sequencing-based mRNA expression data identified 4 subtypes that correlate to 'NEOPLASM.DISEASESTAGE', 'PATHOLOGY.T.STAGE', 'PATHOLOGY.N.STAGE', and 'GENDER'.
-
Consensus hierarchical clustering analysis on sequencing-based mRNA expression data identified 3 subtypes that correlate to 'NEOPLASM.DISEASESTAGE', 'PATHOLOGY.T.STAGE', 'PATHOLOGY.N.STAGE', and 'GENDER'.
-
3 subtypes identified in current cancer cohort by 'MIRSEQ CNMF'. These subtypes do not correlate to any clinical features.
-
3 subtypes identified in current cancer cohort by 'MIRSEQ CHIERARCHICAL'. These subtypes do not correlate to any clinical features.
-
3 subtypes identified in current cancer cohort by 'MIRseq Mature CNMF subtypes'. These subtypes do not correlate to any clinical features.
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7 subtypes identified in current cancer cohort by 'MIRseq Mature cHierClus subtypes'. These subtypes correlate to 'NEOPLASM.DISEASESTAGE' and 'PATHOLOGY.T.STAGE'.
Clinical Features |
Statistical Tests |
Copy Number Ratio CNMF subtypes |
METHLYATION CNMF |
RNAseq CNMF subtypes |
RNAseq cHierClus subtypes |
MIRSEQ CNMF |
MIRSEQ CHIERARCHICAL |
MIRseq Mature CNMF subtypes |
MIRseq Mature cHierClus subtypes |
Time to Death | logrank test |
0.504 (1.00) |
0.00198 (0.144) |
0.0474 (1.00) |
0.206 (1.00) |
0.0409 (1.00) |
0.362 (1.00) |
0.0303 (1.00) |
0.0176 (1.00) |
AGE | Kruskal-Wallis (anova) |
0.509 (1.00) |
0.092 (1.00) |
0.832 (1.00) |
0.0129 (0.814) |
0.487 (1.00) |
0.0606 (1.00) |
0.223 (1.00) |
0.281 (1.00) |
NEOPLASM DISEASESTAGE | Fisher's exact test |
0.00028 (0.0224) |
1e-05 (0.00088) |
1e-05 (0.00088) |
0.00012 (0.00972) |
0.011 (0.714) |
0.0113 (0.726) |
0.00558 (0.385) |
1e-05 (0.00088) |
PATHOLOGY T STAGE | Fisher's exact test |
0.00073 (0.0562) |
1e-05 (0.00088) |
1e-05 (0.00088) |
0.00195 (0.144) |
0.0455 (1.00) |
0.0101 (0.67) |
0.018 (1.00) |
2e-05 (0.00166) |
PATHOLOGY N STAGE | Fisher's exact test |
0.0303 (1.00) |
0.00342 (0.243) |
0.0016 (0.12) |
0.00083 (0.0631) |
0.0333 (1.00) |
0.0267 (1.00) |
0.056 (1.00) |
0.00426 (0.298) |
PATHOLOGY M STAGE | Fisher's exact test |
0.0375 (1.00) |
0.0005 (0.0395) |
0.0153 (0.949) |
0.00665 (0.452) |
0.359 (1.00) |
0.417 (1.00) |
0.392 (1.00) |
0.0965 (1.00) |
GENDER | Fisher's exact test |
0.00263 (0.189) |
0.0168 (1.00) |
0.00052 (0.0406) |
8e-05 (0.00656) |
0.0797 (1.00) |
0.0549 (1.00) |
0.0896 (1.00) |
0.02 (1.00) |
KARNOFSKY PERFORMANCE SCORE | Kruskal-Wallis (anova) |
0.353 (1.00) |
0.0235 (1.00) |
0.00828 (0.555) |
0.473 (1.00) |
0.0367 (1.00) |
0.289 (1.00) |
0.0583 (1.00) |
0.0604 (1.00) |
NUMBERPACKYEARSSMOKED | Kruskal-Wallis (anova) |
0.949 (1.00) |
0.332 (1.00) |
0.245 (1.00) |
0.906 (1.00) |
0.578 (1.00) |
0.625 (1.00) |
0.342 (1.00) |
0.402 (1.00) |
RACE | Fisher's exact test |
0.353 (1.00) |
0.381 (1.00) |
0.425 (1.00) |
0.933 (1.00) |
0.159 (1.00) |
0.0331 (1.00) |
0.544 (1.00) |
0.0922 (1.00) |
ETHNICITY | Fisher's exact test |
0.416 (1.00) |
0.817 (1.00) |
0.56 (1.00) |
0.171 (1.00) |
0.772 (1.00) |
0.2 (1.00) |
0.396 (1.00) |
0.0498 (1.00) |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 76 | 93 | 29 |
P value = 0.504 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Year | |
---|---|---|---|
ALL | 173 | 7 | 2.0 - 5925.0 (508.0) |
subtype1 | 70 | 1 | 2.0 - 5925.0 (623.0) |
subtype2 | 77 | 5 | 3.0 - 3760.0 (510.0) |
subtype3 | 26 | 1 | 2.0 - 2948.0 (265.0) |
P value = 0.509 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 195 | 59.9 (12.3) |
subtype1 | 75 | 59.0 (10.9) |
subtype2 | 92 | 60.6 (13.2) |
subtype3 | 28 | 59.7 (13.2) |
P value = 0.00028 (Fisher's exact test), Q value = 0.022
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV |
---|---|---|---|---|
ALL | 122 | 11 | 42 | 12 |
subtype1 | 57 | 4 | 7 | 1 |
subtype2 | 45 | 5 | 31 | 10 |
subtype3 | 20 | 2 | 4 | 1 |
P value = 0.00073 (Fisher's exact test), Q value = 0.056
nPatients | T1 | T2 | T3+T4 |
---|---|---|---|
ALL | 130 | 18 | 50 |
subtype1 | 60 | 8 | 8 |
subtype2 | 50 | 7 | 36 |
subtype3 | 20 | 3 | 6 |
P value = 0.0303 (Fisher's exact test), Q value = 1
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 33 | 20 | 4 |
subtype1 | 11 | 1 | 0 |
subtype2 | 21 | 18 | 3 |
subtype3 | 1 | 1 | 1 |
P value = 0.0375 (Fisher's exact test), Q value = 1
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 81 | 8 | 96 |
subtype1 | 30 | 0 | 39 |
subtype2 | 42 | 8 | 41 |
subtype3 | 9 | 0 | 16 |
P value = 0.00263 (Fisher's exact test), Q value = 0.19
nPatients | FEMALE | MALE |
---|---|---|
ALL | 58 | 140 |
subtype1 | 12 | 64 |
subtype2 | 34 | 59 |
subtype3 | 12 | 17 |
P value = 0.353 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 52 | 91.2 (16.5) |
subtype1 | 23 | 94.8 (7.9) |
subtype2 | 19 | 86.3 (25.0) |
subtype3 | 10 | 92.0 (7.9) |
P value = 0.949 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 24 | 30.2 (35.9) |
subtype1 | 7 | 24.4 (16.8) |
subtype2 | 13 | 35.2 (46.6) |
subtype3 | 4 | 23.8 (19.3) |
P value = 0.353 (Fisher's exact test), Q value = 1
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 2 | 4 | 49 | 129 |
subtype1 | 2 | 1 | 22 | 45 |
subtype2 | 0 | 2 | 23 | 63 |
subtype3 | 0 | 1 | 4 | 21 |
P value = 0.416 (Fisher's exact test), Q value = 1
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 9 | 153 |
subtype1 | 2 | 63 |
subtype2 | 6 | 67 |
subtype3 | 1 | 23 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 44 | 54 | 88 |
P value = 0.00198 (logrank test), Q value = 0.14
nPatients | nDeath | Duration Range (Median), Year | |
---|---|---|---|
ALL | 162 | 6 | 2.0 - 5925.0 (445.5) |
subtype1 | 36 | 0 | 4.0 - 2816.0 (477.5) |
subtype2 | 44 | 6 | 5.0 - 5925.0 (317.0) |
subtype3 | 82 | 0 | 2.0 - 3950.0 (476.5) |
P value = 0.092 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 183 | 60.3 (12.5) |
subtype1 | 43 | 63.0 (12.1) |
subtype2 | 53 | 61.0 (14.7) |
subtype3 | 87 | 58.6 (11.0) |
P value = 1e-05 (Fisher's exact test), Q value = 0.00088
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV |
---|---|---|---|---|
ALL | 119 | 9 | 42 | 11 |
subtype1 | 33 | 2 | 6 | 2 |
subtype2 | 14 | 3 | 28 | 9 |
subtype3 | 72 | 4 | 8 | 0 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00088
nPatients | T1 | T2 | T3+T4 |
---|---|---|---|
ALL | 125 | 12 | 49 |
subtype1 | 34 | 1 | 9 |
subtype2 | 16 | 5 | 33 |
subtype3 | 75 | 6 | 7 |
P value = 0.00342 (Fisher's exact test), Q value = 0.24
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 32 | 19 | 4 |
subtype1 | 9 | 2 | 1 |
subtype2 | 13 | 17 | 3 |
subtype3 | 10 | 0 | 0 |
P value = 5e-04 (Fisher's exact test), Q value = 0.039
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 74 | 7 | 97 |
subtype1 | 24 | 1 | 16 |
subtype2 | 22 | 6 | 25 |
subtype3 | 28 | 0 | 56 |
P value = 0.0168 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 55 | 131 |
subtype1 | 12 | 32 |
subtype2 | 24 | 30 |
subtype3 | 19 | 69 |
P value = 0.0235 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 53 | 93.2 (10.3) |
subtype1 | 11 | 85.5 (16.3) |
subtype2 | 9 | 95.6 (5.3) |
subtype3 | 33 | 95.2 (7.6) |
P value = 0.332 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 28 | 28.9 (33.9) |
subtype1 | 4 | 67.5 (79.8) |
subtype2 | 7 | 20.1 (11.1) |
subtype3 | 17 | 23.4 (16.2) |
P value = 0.381 (Fisher's exact test), Q value = 1
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 2 | 5 | 42 | 123 |
subtype1 | 1 | 3 | 12 | 25 |
subtype2 | 0 | 1 | 12 | 38 |
subtype3 | 1 | 1 | 18 | 60 |
P value = 0.817 (Fisher's exact test), Q value = 1
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 9 | 141 |
subtype1 | 1 | 33 |
subtype2 | 3 | 37 |
subtype3 | 5 | 71 |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 42 | 65 | 62 | 28 |
P value = 0.0474 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Year | |
---|---|---|---|
ALL | 172 | 7 | 2.0 - 5925.0 (510.5) |
subtype1 | 37 | 0 | 2.0 - 3035.0 (595.0) |
subtype2 | 52 | 6 | 4.0 - 5925.0 (397.0) |
subtype3 | 59 | 1 | 2.0 - 1726.0 (436.0) |
subtype4 | 24 | 0 | 2.0 - 3950.0 (750.5) |
P value = 0.832 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 194 | 59.9 (12.3) |
subtype1 | 42 | 61.5 (11.7) |
subtype2 | 64 | 59.5 (13.8) |
subtype3 | 61 | 59.4 (11.2) |
subtype4 | 27 | 59.3 (12.2) |
P value = 1e-05 (Fisher's exact test), Q value = 0.00088
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV |
---|---|---|---|---|
ALL | 120 | 12 | 42 | 12 |
subtype1 | 25 | 5 | 9 | 0 |
subtype2 | 20 | 4 | 28 | 11 |
subtype3 | 50 | 3 | 4 | 0 |
subtype4 | 25 | 0 | 1 | 1 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00088
nPatients | T1 | T2 | T3+T4 |
---|---|---|---|
ALL | 128 | 19 | 50 |
subtype1 | 28 | 5 | 9 |
subtype2 | 23 | 6 | 36 |
subtype3 | 52 | 7 | 3 |
subtype4 | 25 | 1 | 2 |
P value = 0.0016 (Fisher's exact test), Q value = 0.12
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 32 | 20 | 4 |
subtype1 | 11 | 2 | 0 |
subtype2 | 12 | 18 | 3 |
subtype3 | 7 | 0 | 0 |
subtype4 | 2 | 0 | 1 |
P value = 0.0153 (Fisher's exact test), Q value = 0.95
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 83 | 8 | 93 |
subtype1 | 17 | 0 | 22 |
subtype2 | 30 | 8 | 24 |
subtype3 | 24 | 0 | 32 |
subtype4 | 12 | 0 | 15 |
P value = 0.00052 (Fisher's exact test), Q value = 0.041
nPatients | FEMALE | MALE |
---|---|---|
ALL | 58 | 139 |
subtype1 | 7 | 35 |
subtype2 | 32 | 33 |
subtype3 | 13 | 49 |
subtype4 | 6 | 22 |
P value = 0.00828 (Kruskal-Wallis (anova)), Q value = 0.55
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 54 | 91.5 (16.3) |
subtype1 | 11 | 91.8 (8.7) |
subtype2 | 12 | 80.8 (30.3) |
subtype3 | 25 | 96.8 (6.9) |
subtype4 | 6 | 90.0 (0.0) |
P value = 0.245 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 25 | 30.7 (35.5) |
subtype1 | 4 | 13.2 (7.0) |
subtype2 | 6 | 55.5 (64.9) |
subtype3 | 12 | 25.8 (17.7) |
subtype4 | 3 | 24.3 (9.5) |
P value = 0.425 (Fisher's exact test), Q value = 1
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 2 | 4 | 47 | 130 |
subtype1 | 1 | 0 | 8 | 31 |
subtype2 | 0 | 3 | 14 | 45 |
subtype3 | 1 | 0 | 18 | 37 |
subtype4 | 0 | 1 | 7 | 17 |
P value = 0.56 (Fisher's exact test), Q value = 1
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 9 | 152 |
subtype1 | 1 | 34 |
subtype2 | 4 | 46 |
subtype3 | 2 | 53 |
subtype4 | 2 | 19 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 67 | 64 | 66 |
P value = 0.206 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Year | |
---|---|---|---|
ALL | 172 | 7 | 2.0 - 5925.0 (510.5) |
subtype1 | 59 | 2 | 4.0 - 3760.0 (595.0) |
subtype2 | 52 | 4 | 2.0 - 2816.0 (405.5) |
subtype3 | 61 | 1 | 2.0 - 5925.0 (508.0) |
P value = 0.0129 (Kruskal-Wallis (anova)), Q value = 0.81
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 194 | 59.9 (12.3) |
subtype1 | 66 | 62.4 (12.4) |
subtype2 | 63 | 55.9 (12.6) |
subtype3 | 65 | 61.1 (11.0) |
P value = 0.00012 (Fisher's exact test), Q value = 0.0097
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV |
---|---|---|---|---|
ALL | 120 | 12 | 42 | 12 |
subtype1 | 34 | 3 | 25 | 2 |
subtype2 | 38 | 3 | 11 | 9 |
subtype3 | 48 | 6 | 6 | 1 |
P value = 0.00195 (Fisher's exact test), Q value = 0.14
nPatients | T1 | T2 | T3+T4 |
---|---|---|---|
ALL | 128 | 19 | 50 |
subtype1 | 37 | 5 | 25 |
subtype2 | 40 | 5 | 19 |
subtype3 | 51 | 9 | 6 |
P value = 0.00083 (Fisher's exact test), Q value = 0.063
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 32 | 20 | 4 |
subtype1 | 19 | 7 | 1 |
subtype2 | 4 | 12 | 3 |
subtype3 | 9 | 1 | 0 |
P value = 0.00665 (Fisher's exact test), Q value = 0.45
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 83 | 8 | 93 |
subtype1 | 35 | 2 | 24 |
subtype2 | 26 | 6 | 30 |
subtype3 | 22 | 0 | 39 |
P value = 8e-05 (Fisher's exact test), Q value = 0.0066
nPatients | FEMALE | MALE |
---|---|---|
ALL | 58 | 139 |
subtype1 | 16 | 51 |
subtype2 | 32 | 32 |
subtype3 | 10 | 56 |
P value = 0.473 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 54 | 91.5 (16.3) |
subtype1 | 14 | 92.9 (7.3) |
subtype2 | 16 | 85.6 (27.1) |
subtype3 | 24 | 94.6 (8.3) |
P value = 0.906 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 25 | 30.7 (35.5) |
subtype1 | 7 | 43.3 (63.2) |
subtype2 | 9 | 22.7 (13.2) |
subtype3 | 9 | 29.0 (19.6) |
P value = 0.933 (Fisher's exact test), Q value = 1
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 2 | 4 | 47 | 130 |
subtype1 | 1 | 1 | 15 | 46 |
subtype2 | 0 | 2 | 14 | 42 |
subtype3 | 1 | 1 | 18 | 42 |
P value = 0.171 (Fisher's exact test), Q value = 1
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 9 | 152 |
subtype1 | 3 | 49 |
subtype2 | 5 | 46 |
subtype3 | 1 | 57 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 67 | 65 | 70 |
P value = 0.0409 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Year | |
---|---|---|---|
ALL | 177 | 7 | 2.0 - 5925.0 (494.0) |
subtype1 | 58 | 0 | 2.0 - 3760.0 (526.5) |
subtype2 | 60 | 1 | 2.0 - 2816.0 (429.5) |
subtype3 | 59 | 6 | 2.0 - 5925.0 (649.0) |
P value = 0.487 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 199 | 60.1 (12.4) |
subtype1 | 66 | 61.7 (11.7) |
subtype2 | 63 | 60.0 (10.8) |
subtype3 | 70 | 58.7 (14.2) |
P value = 0.011 (Fisher's exact test), Q value = 0.71
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV |
---|---|---|---|---|
ALL | 124 | 12 | 43 | 12 |
subtype1 | 37 | 6 | 19 | 1 |
subtype2 | 48 | 2 | 8 | 2 |
subtype3 | 39 | 4 | 16 | 9 |
P value = 0.0455 (Fisher's exact test), Q value = 1
nPatients | T1 | T2 | T3+T4 |
---|---|---|---|
ALL | 132 | 19 | 51 |
subtype1 | 39 | 9 | 19 |
subtype2 | 51 | 5 | 9 |
subtype3 | 42 | 5 | 23 |
P value = 0.0333 (Fisher's exact test), Q value = 1
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 34 | 20 | 4 |
subtype1 | 17 | 4 | 1 |
subtype2 | 8 | 3 | 0 |
subtype3 | 9 | 13 | 3 |
P value = 0.359 (Fisher's exact test), Q value = 1
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 84 | 8 | 97 |
subtype1 | 30 | 1 | 28 |
subtype2 | 23 | 2 | 36 |
subtype3 | 31 | 5 | 33 |
P value = 0.0797 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 59 | 143 |
subtype1 | 13 | 54 |
subtype2 | 21 | 44 |
subtype3 | 25 | 45 |
P value = 0.0367 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 54 | 91.5 (16.3) |
subtype1 | 12 | 92.5 (7.5) |
subtype2 | 20 | 96.5 (7.5) |
subtype3 | 22 | 86.4 (23.2) |
P value = 0.578 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 28 | 28.9 (33.9) |
subtype1 | 6 | 15.5 (5.6) |
subtype2 | 13 | 28.6 (18.3) |
subtype3 | 9 | 38.1 (56.0) |
P value = 0.159 (Fisher's exact test), Q value = 1
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 2 | 5 | 49 | 132 |
subtype1 | 0 | 1 | 23 | 38 |
subtype2 | 1 | 2 | 10 | 47 |
subtype3 | 1 | 2 | 16 | 47 |
P value = 0.772 (Fisher's exact test), Q value = 1
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 9 | 157 |
subtype1 | 2 | 52 |
subtype2 | 4 | 51 |
subtype3 | 3 | 54 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 95 | 43 | 64 |
P value = 0.362 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Year | |
---|---|---|---|
ALL | 177 | 7 | 2.0 - 5925.0 (494.0) |
subtype1 | 83 | 3 | 2.0 - 3760.0 (494.0) |
subtype2 | 42 | 0 | 2.0 - 1636.0 (476.5) |
subtype3 | 52 | 4 | 4.0 - 5925.0 (576.5) |
P value = 0.0606 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 199 | 60.1 (12.4) |
subtype1 | 94 | 60.6 (11.5) |
subtype2 | 42 | 63.5 (11.3) |
subtype3 | 63 | 57.2 (13.8) |
P value = 0.0113 (Fisher's exact test), Q value = 0.73
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV |
---|---|---|---|---|
ALL | 124 | 12 | 43 | 12 |
subtype1 | 58 | 5 | 21 | 3 |
subtype2 | 34 | 3 | 5 | 0 |
subtype3 | 32 | 4 | 17 | 9 |
P value = 0.0101 (Fisher's exact test), Q value = 0.67
nPatients | T1 | T2 | T3+T4 |
---|---|---|---|
ALL | 132 | 19 | 51 |
subtype1 | 63 | 10 | 22 |
subtype2 | 35 | 4 | 4 |
subtype3 | 34 | 5 | 25 |
P value = 0.0267 (Fisher's exact test), Q value = 1
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 34 | 20 | 4 |
subtype1 | 17 | 7 | 1 |
subtype2 | 7 | 0 | 0 |
subtype3 | 10 | 13 | 3 |
P value = 0.417 (Fisher's exact test), Q value = 1
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 84 | 8 | 97 |
subtype1 | 39 | 3 | 42 |
subtype2 | 18 | 0 | 24 |
subtype3 | 27 | 5 | 31 |
P value = 0.0549 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 59 | 143 |
subtype1 | 22 | 73 |
subtype2 | 11 | 32 |
subtype3 | 26 | 38 |
P value = 0.289 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 54 | 91.5 (16.3) |
subtype1 | 26 | 90.0 (20.2) |
subtype2 | 12 | 96.7 (4.9) |
subtype3 | 16 | 90.0 (14.6) |
P value = 0.625 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 28 | 28.9 (33.9) |
subtype1 | 9 | 20.3 (13.8) |
subtype2 | 9 | 30.3 (19.2) |
subtype3 | 10 | 35.2 (53.3) |
P value = 0.0331 (Fisher's exact test), Q value = 1
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 2 | 5 | 49 | 132 |
subtype1 | 1 | 1 | 31 | 55 |
subtype2 | 1 | 1 | 5 | 33 |
subtype3 | 0 | 3 | 13 | 44 |
P value = 0.2 (Fisher's exact test), Q value = 1
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 9 | 157 |
subtype1 | 2 | 75 |
subtype2 | 2 | 36 |
subtype3 | 5 | 46 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 68 | 62 | 72 |
P value = 0.0303 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Year | |
---|---|---|---|
ALL | 177 | 7 | 2.0 - 5925.0 (494.0) |
subtype1 | 61 | 0 | 2.0 - 3760.0 (493.0) |
subtype2 | 56 | 1 | 2.0 - 2816.0 (421.0) |
subtype3 | 60 | 6 | 4.0 - 5925.0 (654.0) |
P value = 0.223 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 199 | 60.1 (12.4) |
subtype1 | 67 | 62.0 (11.6) |
subtype2 | 60 | 60.6 (10.6) |
subtype3 | 72 | 58.0 (14.2) |
P value = 0.00558 (Fisher's exact test), Q value = 0.39
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV |
---|---|---|---|---|
ALL | 124 | 12 | 43 | 12 |
subtype1 | 36 | 5 | 21 | 1 |
subtype2 | 45 | 3 | 8 | 1 |
subtype3 | 43 | 4 | 14 | 10 |
P value = 0.018 (Fisher's exact test), Q value = 1
nPatients | T1 | T2 | T3+T4 |
---|---|---|---|
ALL | 132 | 19 | 51 |
subtype1 | 39 | 8 | 21 |
subtype2 | 48 | 7 | 7 |
subtype3 | 45 | 4 | 23 |
P value = 0.056 (Fisher's exact test), Q value = 1
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 34 | 20 | 4 |
subtype1 | 18 | 4 | 1 |
subtype2 | 6 | 3 | 0 |
subtype3 | 10 | 13 | 3 |
P value = 0.392 (Fisher's exact test), Q value = 1
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 84 | 8 | 97 |
subtype1 | 27 | 1 | 32 |
subtype2 | 25 | 1 | 31 |
subtype3 | 32 | 6 | 34 |
P value = 0.0896 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 59 | 143 |
subtype1 | 16 | 52 |
subtype2 | 15 | 47 |
subtype3 | 28 | 44 |
P value = 0.0583 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 54 | 91.5 (16.3) |
subtype1 | 13 | 93.1 (7.5) |
subtype2 | 17 | 96.5 (7.9) |
subtype3 | 24 | 87.1 (22.4) |
P value = 0.342 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 28 | 28.9 (33.9) |
subtype1 | 9 | 32.6 (57.5) |
subtype2 | 12 | 30.3 (17.9) |
subtype3 | 7 | 21.6 (10.2) |
P value = 0.544 (Fisher's exact test), Q value = 1
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 2 | 5 | 49 | 132 |
subtype1 | 0 | 1 | 21 | 42 |
subtype2 | 1 | 1 | 11 | 43 |
subtype3 | 1 | 3 | 17 | 47 |
P value = 0.396 (Fisher's exact test), Q value = 1
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 9 | 157 |
subtype1 | 1 | 53 |
subtype2 | 4 | 49 |
subtype3 | 4 | 55 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
---|---|---|---|---|---|---|---|
Number of samples | 23 | 31 | 33 | 27 | 33 | 37 | 18 |
P value = 0.0176 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Year | |
---|---|---|---|
ALL | 177 | 7 | 2.0 - 5925.0 (494.0) |
subtype1 | 21 | 0 | 2.0 - 3035.0 (510.0) |
subtype2 | 25 | 2 | 26.0 - 2639.0 (600.0) |
subtype3 | 32 | 1 | 2.0 - 3760.0 (375.5) |
subtype4 | 27 | 0 | 2.0 - 2816.0 (516.0) |
subtype5 | 28 | 2 | 4.0 - 5925.0 (644.5) |
subtype6 | 33 | 0 | 2.0 - 2072.0 (586.0) |
subtype7 | 11 | 2 | 7.0 - 1967.0 (97.0) |
P value = 0.281 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 199 | 60.1 (12.4) |
subtype1 | 22 | 63.0 (12.0) |
subtype2 | 31 | 62.7 (12.7) |
subtype3 | 32 | 59.8 (10.5) |
subtype4 | 27 | 59.2 (11.3) |
subtype5 | 33 | 62.6 (12.6) |
subtype6 | 37 | 57.9 (11.1) |
subtype7 | 17 | 53.9 (17.3) |
P value = 1e-05 (Fisher's exact test), Q value = 0.00088
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV |
---|---|---|---|---|
ALL | 124 | 12 | 43 | 12 |
subtype1 | 16 | 1 | 4 | 0 |
subtype2 | 12 | 2 | 14 | 3 |
subtype3 | 24 | 2 | 4 | 0 |
subtype4 | 24 | 0 | 1 | 0 |
subtype5 | 18 | 1 | 8 | 6 |
subtype6 | 26 | 3 | 4 | 0 |
subtype7 | 4 | 3 | 8 | 3 |
P value = 2e-05 (Fisher's exact test), Q value = 0.0017
nPatients | T1 | T2 | T3+T4 |
---|---|---|---|
ALL | 132 | 19 | 51 |
subtype1 | 18 | 2 | 3 |
subtype2 | 13 | 3 | 15 |
subtype3 | 24 | 5 | 4 |
subtype4 | 25 | 1 | 1 |
subtype5 | 18 | 1 | 14 |
subtype6 | 29 | 4 | 4 |
subtype7 | 5 | 3 | 10 |
P value = 0.00426 (Fisher's exact test), Q value = 0.3
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 34 | 20 | 4 |
subtype1 | 5 | 1 | 0 |
subtype2 | 11 | 6 | 1 |
subtype3 | 2 | 0 | 0 |
subtype4 | 2 | 0 | 0 |
subtype5 | 8 | 4 | 3 |
subtype6 | 5 | 0 | 0 |
subtype7 | 1 | 9 | 0 |
P value = 0.0965 (Fisher's exact test), Q value = 1
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 84 | 8 | 97 |
subtype1 | 9 | 0 | 10 |
subtype2 | 16 | 3 | 11 |
subtype3 | 15 | 0 | 15 |
subtype4 | 8 | 0 | 19 |
subtype5 | 16 | 2 | 14 |
subtype6 | 14 | 0 | 19 |
subtype7 | 6 | 3 | 9 |
P value = 0.02 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 59 | 143 |
subtype1 | 6 | 17 |
subtype2 | 9 | 22 |
subtype3 | 7 | 26 |
subtype4 | 10 | 17 |
subtype5 | 11 | 22 |
subtype6 | 5 | 32 |
subtype7 | 11 | 7 |
P value = 0.0604 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 54 | 91.5 (16.3) |
subtype1 | 4 | 100.0 (0.0) |
subtype2 | 6 | 76.7 (38.3) |
subtype3 | 10 | 96.0 (9.7) |
subtype4 | 6 | 95.0 (5.5) |
subtype5 | 10 | 93.0 (6.7) |
subtype6 | 13 | 93.8 (7.7) |
subtype7 | 5 | 80.0 (22.4) |
P value = 0.402 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 28 | 28.9 (33.9) |
subtype1 | 2 | 12.5 (10.6) |
subtype2 | 4 | 23.2 (11.4) |
subtype3 | 6 | 35.8 (20.4) |
subtype4 | 9 | 17.6 (8.8) |
subtype5 | 4 | 57.2 (85.2) |
subtype6 | 2 | 30.0 (28.3) |
subtype7 | 1 | 28.0 (NA) |
P value = 0.0922 (Fisher's exact test), Q value = 1
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 2 | 5 | 49 | 132 |
subtype1 | 0 | 0 | 10 | 11 |
subtype2 | 0 | 0 | 6 | 24 |
subtype3 | 1 | 1 | 10 | 18 |
subtype4 | 0 | 0 | 4 | 21 |
subtype5 | 0 | 3 | 5 | 24 |
subtype6 | 1 | 0 | 8 | 25 |
subtype7 | 0 | 1 | 6 | 9 |
P value = 0.0498 (Fisher's exact test), Q value = 1
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 9 | 157 |
subtype1 | 0 | 19 |
subtype2 | 1 | 23 |
subtype3 | 0 | 28 |
subtype4 | 5 | 20 |
subtype5 | 1 | 25 |
subtype6 | 1 | 29 |
subtype7 | 1 | 13 |
-
Cluster data file = KIRP-TP.mergedcluster.txt
-
Clinical data file = KIRP-TP.merged_data.txt
-
Number of patients = 202
-
Number of clustering approaches = 8
-
Number of selected clinical features = 11
-
Exclude small clusters that include fewer than K patients, K = 3
consensus non-negative matrix factorization clustering approach (Brunet et al. 2004)
Resampling-based clustering method (Monti et al. 2003)
For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R
For binary clinical features, two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.