rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF3(2), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(2), E2F2(2), MDM2(1), PRB1(2), TP53(7) 2124020 19 16 19 1 5 2 3 3 5 1 0.0495 0.00184 1.000 2 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(2), ADORA2A(3), ADORA3(2), P2RY1(2), P2RY2(1), P2RY6(2) 1486127 12 11 12 1 5 2 3 2 0 0 0.0453 0.0200 1.000 3 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(2) 127344 2 2 2 0 0 0 0 0 2 0 0.860 0.0464 1.000 4 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1), RAB11A(1), RAB1A(1), RAB27A(2), RAB3A(1), RAB6A(1) 1075847 7 7 7 1 1 0 3 1 2 0 0.499 0.0539 1.000 5 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP2(1), ACP5(1), ACP6(4), ACPP(2), ACPT(1), ENPP1(6), ENPP3(1), FLAD1(1), MTMR2(2), MTMR6(4), PHPT1(1) 3795599 24 19 22 1 9 1 4 7 3 0 0.0143 0.0979 1.000 6 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(3), ARG1(1), GLS(5), OAT(1), PRODH(1) 1428662 11 11 11 2 5 0 0 3 3 0 0.453 0.100 1.000 7 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(4), HADHA(3) 1371296 7 7 7 0 1 0 2 3 0 1 0.193 0.137 1.000 8 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR2(2), MTMR6(4), NFS1(2), PHPT1(1), THTPA(1), TPK1(1) 1613515 11 10 10 1 5 2 3 1 0 0 0.197 0.145 1.000 9 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(1), ACO2(3), FH(2), IDH1(2), IDH2(4), MDH1(1), SDHB(2), SUCLA2(1) 2250565 16 15 16 2 8 1 1 1 5 0 0.113 0.149 1.000 10 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(1), CCNE1(2), CCNE2(1), CDK2(1), CDK4(1), CDKN2A(2), E2F2(2), PRB1(2) 2277484 12 11 12 0 4 0 2 2 3 1 0.0594 0.179 1.000 11 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(2), PAPSS2(4), SULT1A2(2), SULT1E1(2) 1526973 10 9 9 1 4 0 3 2 1 0 0.253 0.193 1.000 12 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(1), GGT1(2), SHMT1(1), SHMT2(3) 1068963 7 6 7 0 2 2 2 1 0 0 0.113 0.205 1.000 13 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOB(3), ALDOC(1), TPI1(3) 981919 7 6 7 1 3 0 0 1 3 0 0.438 0.226 1.000 14 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GBA(1), GBA3(1), GGT1(2), SHMT1(1), SHMT2(3) 1419223 8 7 8 0 2 2 2 2 0 0 0.101 0.245 1.000 15 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), CAMP(1), DAG1(6), ITPKA(3), ITPKB(3) 1528954 14 11 14 3 5 1 1 2 5 0 0.543 0.246 1.000 16 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(2), CDK2(1), CUL1(4), FBXW7(3), TFDP1(1) 2094098 11 10 11 0 4 1 2 2 2 0 0.0817 0.251 1.000 17 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(1), IL1B(1), MST1(5), MST1R(1), TNF(1) 1648155 9 8 8 0 2 0 1 1 5 0 0.164 0.256 1.000 18 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(2), CD4(2), IL1B(1), IL5RA(2) 1343993 7 7 7 1 3 0 1 1 2 0 0.472 0.297 1.000 19 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(3), MAP3K14(2), NFKB1(3), NFKBIA(2), RELA(2), TP53(7) 2528680 19 18 19 3 5 3 3 4 4 0 0.260 0.327 1.000 20 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(2), AASDHPPT(1), AASS(2), KARS(2) 1742497 7 7 7 1 4 0 1 2 0 0 0.417 0.329 1.000 21 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 TPI1(3) 414450 3 3 3 1 2 0 0 1 0 0 0.680 0.331 1.000 22 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(4), UGDH(1) 988320 5 5 5 1 3 0 0 1 1 0 0.572 0.332 1.000 23 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA11(2), NDUFB2(1), NDUFB4(1), NDUFB5(3), NDUFB6(2), NDUFB7(1), NDUFS1(2), NDUFS2(1), NDUFV1(2) 1772256 15 15 14 5 4 1 1 3 6 0 0.819 0.338 1.000 24 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(2), SUCLA2(1) 540014 3 3 3 1 1 0 1 1 0 0 0.685 0.346 1.000 25 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(2), CDK2(1), CUL1(4), NEDD8(1), RBX1(1), SKP2(1), TFDP1(1) 2160824 11 10 11 0 4 1 1 2 3 0 0.0567 0.364 1.000 26 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A2(2), BCMO1(1), RDH5(2) 973757 5 5 5 1 2 0 0 3 0 0 0.570 0.368 1.000 27 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASDHPPT(1), AASS(2), KARS(2) 1184417 5 5 5 1 4 0 1 0 0 0 0.571 0.371 1.000 28 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP2(1), ACP5(1), ACPP(2), ACPT(1), ENPP1(6), ENPP3(1), FLAD1(1) 2446799 13 10 13 1 5 1 1 4 2 0 0.160 0.376 1.000 29 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), HADHA(3), HADHB(1), HSD17B10(2), HSD17B4(1), MECR(3), PPT2(1) 2149226 12 10 12 0 5 1 4 2 0 0 0.0308 0.411 1.000 30 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(3), CS(1), FH(2), IDH2(4), MDH1(1), OGDH(7), SDHA(4), SUCLA2(1) 2376974 23 19 23 6 10 3 5 0 5 0 0.355 0.416 1.000 31 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(2), CSAD(2), GAD1(4), GAD2(2), GGT1(2) 1465236 12 11 12 3 7 0 2 2 1 0 0.440 0.437 1.000 32 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(1), CCNE1(2), CDK2(1), CUL1(4), SKP2(1), TFDP1(1) 2165221 10 9 10 0 5 1 1 2 1 0 0.0724 0.469 1.000 33 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2), GOT2(2) 663188 4 4 4 1 3 0 0 0 1 0 0.568 0.494 1.000 34 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(4), UGDH(1) 1250882 5 5 5 1 3 0 0 1 1 0 0.578 0.499 1.000 35 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(4), EHHADH(2), HADHA(3) 1228249 9 8 8 2 4 0 1 3 1 0 0.464 0.501 1.000 36 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(3), ACOX3(6), PLA2G12A(2), PLA2G2D(3), PLA2G3(1), PLA2G4A(3), PLA2G6(3) 2600528 21 18 21 3 10 1 6 1 3 0 0.0711 0.505 1.000 37 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(1), PLCD1(5), TGM2(1) 1267683 7 7 7 0 6 0 0 0 1 0 0.106 0.556 1.000 38 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 MAX(1), TP53(7), WT1(1) 1786017 9 9 9 2 3 2 1 2 1 0 0.484 0.557 1.000 39 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(6), APOBEC1(1), APOBEC3B(1), APOBEC3G(2) 1844010 10 10 10 2 3 3 0 4 0 0 0.539 0.560 1.000 40 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CLOCK(3), CRY1(1), CRY2(1), CSNK1E(3), PER1(2) 2178928 10 10 10 2 3 0 4 3 0 0 0.404 0.571 1.000 41 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(1), CTH(2), GOT1(2), GOT2(2), LDHB(1), MPST(2) 1713007 10 8 10 1 7 0 1 1 1 0 0.163 0.578 1.000 42 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(1), EPHB1(5), ITGA1(3), ITGB1(5), L1CAM(1), LYN(1), SELP(2) 3957248 19 17 19 3 5 4 4 1 5 0 0.282 0.580 1.000 43 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(2), GNB1(2), PLCB1(2), TUB(1) 1796701 7 6 7 1 1 1 2 3 0 0 0.402 0.593 1.000 44 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST3GAL4(3), ST6GALNAC2(2), ST6GALNAC4(1) 1424223 6 5 6 1 2 1 3 0 0 0 0.316 0.600 1.000 45 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), B4GALT7(1), HS3ST2(1), HS3ST3A1(1), XYLT1(2), XYLT2(2) 1713734 9 8 9 2 4 1 2 0 2 0 0.289 0.608 1.000 46 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), B4GALT7(1), HS3ST2(1), HS3ST3A1(1), XYLT1(2), XYLT2(2) 1713734 9 8 9 2 4 1 2 0 2 0 0.289 0.608 1.000 47 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(1), CD3G(1), CD4(2) 813329 4 4 4 1 3 0 0 1 0 0 0.612 0.627 1.000 48 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(3), BMPR1A(1), BMPR1B(1) 1576282 5 5 5 1 2 1 1 0 1 0 0.546 0.628 1.000 49 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(1), FOSB(3), GRIA2(2) 951284 6 5 6 2 4 0 0 0 2 0 0.681 0.632 1.000 50 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3G(1) 289764 1 1 1 0 1 0 0 0 0 0 0.779 0.636 1.000 51 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(2), ERBB4(5), NRG2(1), NRG3(4), PSEN1(2) 2271563 14 12 14 3 5 2 4 2 1 0 0.382 0.636 1.000 52 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(2) 759463 2 2 2 1 0 0 0 1 1 0 0.944 0.642 1.000 53 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(2), PARK2(1), SNCAIP(2), UBE2F(1), UBE2G1(1), UBE2L3(2) 1608877 9 8 9 2 4 0 3 1 1 0 0.398 0.642 1.000 54 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRB(1), HMOX1(1), IL10(1), IL10RA(5), JAK1(4), STAT1(2), STAT3(1), STAT5A(3), TNF(1) 3082739 19 15 19 4 8 3 2 2 4 0 0.373 0.659 1.000 55 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(1), BAD(1), BAK1(1), BCL10(1), BCL2L11(1), BID(2), CASP8AP2(6), CASP9(2), CES1(1) 2817176 16 14 16 3 5 2 3 4 2 0 0.378 0.666 1.000 56 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(2), ESR1(1), GREB1(7), MTA1(6), MTA3(1), PDZK1(1) 2802030 18 12 17 2 8 3 2 2 3 0 0.130 0.685 1.000 57 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), CPS1(2), GLS(5), GOT1(2) 1956341 10 10 10 2 6 1 0 2 1 0 0.471 0.687 1.000 58 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(5), GLS2(1), GLUD2(11) 1141741 17 16 11 5 7 0 0 8 2 0 0.609 0.703 1.000 59 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(2), PGLYRP2(1) 452887 3 3 3 2 0 0 1 2 0 0 0.879 0.712 1.000 60 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP2A13(3), CYP2A6(3), CYP2A7(1), XDH(2) 2012718 9 8 9 2 4 1 3 1 0 0 0.370 0.715 1.000 61 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), B4GALT5(1), ST3GAL3(2), ST3GAL4(3) 1982355 10 7 10 0 6 1 2 1 0 0 0.0358 0.716 1.000 62 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(3), GOT1(2), GOT2(2) 1183183 7 6 7 1 6 0 0 0 1 0 0.282 0.725 1.000 63 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 HGD(1) 563456 1 1 1 1 0 0 1 0 0 0 0.958 0.737 1.000 64 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(5), AGT(3), AGTR2(1), BDKRB2(1), KNG1(2), NOS3(3) 2549067 15 14 15 4 4 4 2 4 1 0 0.431 0.749 1.000 65 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT2(2), FUT6(1), ST3GAL3(2) 1287140 5 4 5 0 3 1 0 1 0 0 0.197 0.755 1.000 66 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(4), ACAA2(1), EHHADH(2), HADHA(3), HADHB(1) 2116983 11 9 11 2 5 0 2 3 1 0 0.392 0.761 1.000 67 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(3), ALDOC(1), GOT1(2), GOT2(2), GPT(2), MDH1(1), ME1(1), ME2(1), ME3(3), PKLR(1), RPE(2), RPIA(1), TKT(2), TPI1(3) 4561062 25 20 25 3 11 1 4 3 6 0 0.0414 0.769 1.000 68 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(3), ALDOC(1), GOT1(2), GOT2(2), GPT(2), MDH1(1), ME1(1), ME3(3), PGK2(1), PKLR(1), RPE(2), RPIA(1), TKT(2), TKTL2(1), TPI1(3) 5093936 26 21 26 3 11 2 4 3 6 0 0.0327 0.779 1.000 69 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 FUT2(2), ST3GAL3(2), ST3GAL4(3) 1815004 7 6 7 0 4 1 1 1 0 0 0.111 0.783 1.000 70 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(1), CYP2C9(1) 504993 2 2 2 0 2 0 0 0 0 0 0.599 0.783 1.000 71 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(1), HLCS(1), SPCS1(1) 783248 3 2 3 0 2 0 1 0 0 0 0.388 0.790 1.000 72 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(2), CHST11(1), PAPSS2(4), SULT1A2(2), SULT1E1(2) 2323315 11 9 10 2 5 0 3 2 1 0 0.326 0.817 1.000 73 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 COASY(1), DPYD(4), DPYS(4), ENPP1(6), ENPP3(1), PANK2(2), PANK3(3), PANK4(2), PPCS(1) 3520548 24 17 24 5 6 2 3 5 8 0 0.377 0.817 1.000 74 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(1), CD34(1), CD3G(1), CD4(2), CD58(1) 1570622 6 5 6 1 3 1 0 1 1 0 0.485 0.821 1.000 75 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(3), CYP11A1(2), CYP17A1(2), HSD11B1(1) 1745742 8 6 8 2 3 2 1 1 1 0 0.444 0.822 1.000 76 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 ENDOG(1), HMGB1(3), HMGB2(2), TOP2A(5), TOP2B(4) 2431618 15 14 15 4 4 1 3 3 4 0 0.756 0.823 1.000 77 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(5), BHMT(6), CBS(1), CTH(2), DNMT1(9), DNMT3A(7), DNMT3B(2), MARS(3), MARS2(1), MAT1A(1), MAT2B(1), MTR(2) 4413510 40 27 40 9 16 2 9 5 8 0 0.232 0.828 1.000 78 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(2), POLD1(4), POLD2(2), POLG(6), POLQ(8) 4232655 22 16 22 3 9 2 1 4 6 0 0.169 0.831 1.000 79 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT10(2), GALNT2(5), GALNT3(1), GALNT4(1), GALNT6(3), GALNT7(1), GALNT9(1), ST3GAL4(3), WBSCR17(4) 3664020 21 18 20 4 9 2 3 2 5 0 0.243 0.833 1.000 80 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(2), AMT(1), ATIC(1), GART(3), MTHFD1(3), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(2), SHMT1(1), SHMT2(3), TYMS(1) 4513107 20 17 20 3 6 2 4 6 2 0 0.156 0.833 1.000 81 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1) 755171 1 1 1 1 0 0 0 1 0 0 0.960 0.841 1.000 82 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 HMGCL(1), OXCT1(1) 850287 2 2 2 1 1 0 0 1 0 0 0.831 0.849 1.000 83 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(2), F13B(2), HSD17B1(1), HSD17B4(1), HSD17B7(1) 2036168 7 6 7 2 2 1 2 0 2 0 0.684 0.850 1.000 84 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1) 426932 1 1 1 1 1 0 0 0 0 0 0.908 0.851 1.000 85 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT2(2), GBGT1(1), GLA(1), NAGA(1), ST3GAL4(3) 2547254 8 8 8 1 4 1 1 1 1 0 0.233 0.857 1.000 86 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(2) 599962 2 2 2 0 2 0 0 0 0 0 0.504 0.861 1.000 87 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1) 2020386 15 13 15 4 8 1 2 4 0 0 0.375 0.866 1.000 88 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1) 2020386 15 13 15 4 8 1 2 4 0 0 0.375 0.866 1.000 89 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(3), CDKN1A(1), EPOR(3), HIF1A(2), JAK2(3), NFKB1(3), NFKBIA(2), RELA(2), SOD2(1) 3235338 20 15 20 4 8 3 1 3 4 1 0.359 0.871 1.000 90 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 FMOD(1), KERA(1) 905113 2 2 2 1 1 0 1 0 0 0 0.784 0.875 1.000 91 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(1), BCAR1(2), ITGB1(5), PIK3CA(2), PIK3R1(3), PTEN(5), PTK2(1), SHC1(1), SOS1(3) 4892430 23 21 23 9 2 1 6 4 10 0 0.906 0.879 1.000 92 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(4), ACADVL(3), ACSL1(2), ACSL4(1), CPT1A(2), CPT2(1), EHHADH(2), HADHA(3), PECR(2), SCP2(3), SLC25A20(1) 4248069 24 16 24 3 13 0 4 4 2 1 0.0767 0.880 1.000 93 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(4), ACO1(1), ACO2(3), ACSS1(3), ACSS2(1), FH(2), IDH1(2), IDH2(4), MDH1(1), SUCLA2(1) 3355716 22 17 22 5 12 2 1 1 6 0 0.282 0.882 1.000 94 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR1(1), JAK1(4), JAK2(3), STAT1(2) 2054182 10 10 10 3 3 3 1 2 1 0 0.738 0.892 1.000 95 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(3), NFKBIA(2), PLCB1(2), RELA(2) 2082004 9 8 9 3 2 2 1 2 2 0 0.785 0.896 1.000 96 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3G(1), IL2RA(1), TGFB1(2), TGFBR1(1), TGFBR2(1), TOB1(3) 2680355 9 8 9 2 3 0 3 2 1 0 0.410 0.897 1.000 97 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(1), GSS(1), NFKB1(3), NOX1(2), RELA(2), TNF(1), XDH(2) 2523760 12 8 12 3 5 2 1 1 3 0 0.525 0.899 1.000 98 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(4), ACOX1(3), ACOX3(6), ELOVL5(1), ELOVL6(3), FADS1(1), FASN(9), HADHA(3), PECR(2) 3765169 32 21 32 7 13 1 9 5 4 0 0.129 0.900 1.000 99 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), LPL(1), NR3C1(2), RXRA(2), TNF(1) 1456174 7 7 7 4 2 1 1 1 2 0 0.901 0.900 1.000 100 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(1), FUT2(2) 1554570 3 3 3 0 1 0 0 2 0 0 0.468 0.902 1.000 101 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(1), CARS2(1), CTH(2), GOT1(2), GOT2(2), LDHAL6B(1), LDHB(1), MPST(2), SULT1C2(1), SULT1C4(3), SULT4A1(1) 3168418 17 13 17 3 10 0 1 3 3 0 0.215 0.904 1.000 102 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(2), CHRNA1(1), VAMP2(1) 816024 4 3 4 2 1 0 1 2 0 0 0.856 0.907 1.000 103 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SRP19(1), SRP68(2), SRP72(1) 1895947 5 5 5 1 3 0 0 2 0 0 0.542 0.914 1.000 104 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(2), APEX1(2), CREBBP(5), HMGB2(2), NME1(1), PRF1(2) 2685108 14 13 14 4 5 0 3 2 4 0 0.550 0.915 1.000 105 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(2), ADSS(1), HPRT1(1), IMPDH1(1), MTHFD2(1), OAZ1(1), POLB(2), POLD1(4), POLG(6), PRPS2(3), RRM1(3) 3211632 25 19 25 5 12 3 2 3 5 0 0.242 0.920 1.000 106 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDKN1A(1), CHEK1(2), NEK1(1), WEE1(1) 1802733 5 4 5 1 3 1 0 1 0 0 0.614 0.923 1.000 107 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP2(1), ACP5(1), ACP6(4), ACPP(2), ACPT(1), ALPI(3), ALPL(3), ALPP(2), ALPPL2(1), CMBL(2), CYP3A4(2), CYP3A43(2), CYP3A7(1), DHRS1(1), DHRS2(1), PON2(2), PON3(2) 4572936 31 22 30 8 15 2 3 3 8 0 0.359 0.928 1.000 108 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(1), PNPO(1), PSAT1(2) 1217894 4 4 4 2 3 0 0 0 1 0 0.866 0.931 1.000 109 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(5), POLA2(1), POLB(2), POLD1(4), POLD2(2), POLD4(1), POLG(6), POLG2(1), POLI(3), POLK(2), POLM(2), POLQ(8), PRIM1(1), PRIM2(3), REV1(2), REV3L(4), RFC5(2) 10322769 49 36 49 7 17 5 7 9 11 0 0.0901 0.939 1.000 110 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(1), PTK2B(1) 1699498 3 3 3 1 1 0 2 0 0 0 0.695 0.940 1.000 111 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(4), JAK2(3), JAK3(4), STAT3(1), TYK2(2) 3000537 14 11 13 3 7 2 1 2 2 0 0.358 0.941 1.000 112 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CFLAR(1), PDE6D(1) 969818 2 2 2 2 1 0 0 0 1 0 0.953 0.941 1.000 113 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(4), EHHADH(2), HADHA(3), HSD17B10(2), HSD17B4(1), NTAN1(2), SIRT2(1), SIRT7(1) 2998258 16 12 15 3 7 1 3 3 2 0 0.295 0.943 1.000 114 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP1(2), RANBP2(7) 2080103 10 10 10 3 2 0 2 5 1 0 0.700 0.946 1.000 115 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(5), CBS(1), CTH(2), GGT1(2), MARS(3), MARS2(1), MAT1A(1), MAT2B(1), PAPSS2(4), SCLY(3), SEPHS1(1) 3137157 24 20 24 7 10 1 6 3 4 0 0.482 0.949 1.000 116 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 NR1I3(1), PTGS1(1), PTGS2(2) 1334274 4 3 4 1 3 0 0 1 0 0 0.601 0.951 1.000 117 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(2), CSF1(1), IL9(1) 1552463 4 3 4 1 2 0 0 1 1 0 0.619 0.952 1.000 118 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(2), F2(1), F2R(1), FGA(1), FGB(1), PLAT(2), PLAU(1), PLG(2), SERPINB2(1), SERPINE1(1) 3374383 14 13 14 3 6 1 3 3 1 0 0.434 0.953 1.000 119 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(3), GBA(1), GBA3(1), MPO(3), PRDX6(2), TPO(1) 2127895 11 10 11 4 2 2 2 4 1 0 0.725 0.954 1.000 120 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(5), CSF1(1), FCGR3A(2), IL1B(1), SELL(2), SPN(1), TGFB1(2), TNF(1), TNFRSF1B(1), TNFSF8(2) 3415354 18 14 18 4 8 1 2 2 5 0 0.280 0.954 1.000 121 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(2), EGFR(2), ERBB3(3), NRG1(4) 2592926 11 9 11 3 4 0 2 2 3 0 0.571 0.956 1.000 122 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), SDHA(4), SDHB(2), SDHD(2) 1659163 9 8 9 3 3 0 3 2 1 0 0.635 0.958 1.000 123 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 37 ANPEP(5), G6PD(1), GCLC(3), GGT1(2), GPX1(1), GPX4(1), GSS(1), GSTA1(1), GSTA2(1), GSTA3(1), GSTA5(2), GSTK1(1), GSTM1(1), GSTM4(1), GSTO2(1), GSTP1(2), GSTT1(2), IDH1(2), IDH2(4), MGST2(1), OPLAH(5), TXNDC12(1) 5665573 40 28 40 8 15 4 10 8 3 0 0.0848 0.959 1.000 124 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(5), G6PD(1), GCLC(3), GGT1(2), GPX1(1), GPX4(1), GSS(1), GSTA1(1), GSTA2(1), GSTA3(1), GSTM1(1), GSTM4(1), GSTO2(1), GSTP1(2), GSTT1(2), IDH1(2), IDH2(4), MGST2(1) 4653549 31 23 31 7 12 3 7 7 2 0 0.200 0.961 1.000 125 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(1), CHPT1(1), HEMK1(1), LCMT1(1), METTL2B(1), PCYT1A(2), PCYT1B(2), PRMT2(2), PRMT3(1), PRMT5(2), PRMT6(1), PRMT7(3), WBSCR22(1) 3564059 19 17 19 7 9 3 0 1 6 0 0.690 0.962 1.000 126 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(2), IL10(1) 1000097 3 2 3 0 3 0 0 0 0 0 0.351 0.964 1.000 127 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(2), CYP11B1(2), CYP17A1(2), CYP21A2(1), HSD11B1(1) 2381224 8 7 8 6 3 0 1 1 3 0 0.944 0.966 1.000 128 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(2), CYP11B1(2), CYP17A1(2), CYP21A2(1), HSD11B1(1) 2381224 8 7 8 6 3 0 1 1 3 0 0.944 0.966 1.000 129 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(1), COQ6(4), NDUFB11(1) 1033613 6 5 6 3 4 0 0 1 1 0 0.814 0.969 1.000 130 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(3), ASPH(1), EP300(11), HIF1A(2), NOS3(3), P4HB(2), VHL(2) 4302239 24 18 24 6 10 3 3 1 6 1 0.591 0.970 1.000 131 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(2), EGF(2), EGFR(2), TFRC(2) 3231944 8 7 8 0 4 0 0 3 1 0 0.103 0.970 1.000 132 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 HRAS(1), PTK2B(1), SHC1(1), SOS1(3), SRC(2) 2219673 8 6 8 2 4 1 1 0 2 0 0.514 0.970 1.000 133 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CSF1(1), LDLR(2), LPL(1) 1339551 4 4 4 3 0 0 1 1 2 0 0.923 0.971 1.000 134 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(1), HLA-A(1), ITGB1(5), KLRC1(1), KLRC2(1), KLRC3(1), LAT(2), PAK1(1), PIK3CA(2), PIK3R1(3), PTK2B(1), RAC1(1), SYK(2), VAV1(1) 4722741 23 18 23 5 6 1 4 4 7 1 0.561 0.971 1.000 135 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 ICAM1(1), ITGA4(2), ITGAL(3), ITGB1(5), ITGB2(3), SELE(1), SELL(2) 3066363 17 15 17 7 5 1 4 3 4 0 0.836 0.974 1.000 136 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA2(1), IL4R(1), JAK1(4), JAK2(3), TYK2(2) 2643022 11 8 10 3 5 2 1 1 2 0 0.565 0.975 1.000 137 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA2(1), IL4R(1), JAK1(4), JAK2(3), TYK2(2) 2643022 11 8 10 3 5 2 1 1 2 0 0.565 0.975 1.000 138 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), CHST1(1), CHST2(3), CHST6(1), ST3GAL3(2), ST3GAL4(3) 3123278 14 11 14 3 6 3 4 1 0 0 0.242 0.976 1.000 139 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 COASY(1), DPYD(4), DPYS(4), ENPP1(6), ENPP3(1), ILVBL(2), PANK2(2), PANK3(3), PANK4(2), PPCDC(1), PPCS(1) 4378563 27 19 27 8 7 3 3 6 8 0 0.604 0.976 1.000 140 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), ALG5(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), B4GALT5(1), DDOST(1), DPAGT1(2), MAN1B1(1), MGAT1(1), MGAT2(1), MGAT3(1), MGAT4B(1), MGAT5(1), RPN1(1), RPN2(1), ST6GAL1(1) 5050110 18 12 18 2 8 0 5 0 5 0 0.0760 0.976 1.000 141 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(3), GBA3(1), MPO(3), PRDX2(1), PRDX6(2), TPO(1) 2453389 11 10 11 4 2 2 2 4 1 0 0.736 0.978 1.000 142 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(5), AGT(3), AGTR2(1), EDNRB(3), EGF(2), EGFR(2), FOS(1), HRAS(1), NFKB1(3), PLCG1(1), RELA(2) 5174234 24 16 24 4 10 2 3 4 5 0 0.148 0.979 1.000 143 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD3G(1), CD86(3), CTLA4(2), ICOS(1), PIK3CA(2), PIK3R1(3), PTPN11(2) 3211255 14 14 14 4 2 1 5 3 3 0 0.737 0.980 1.000 144 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(2), CYP51A1(3), DHCR24(1), DHCR7(1), EBP(1), FDFT1(1), FDPS(1), GGCX(2), HMGCR(4), HSD17B7(1), IDI2(1), LSS(3), MVD(1), MVK(2), PMVK(1), SQLE(1), TM7SF2(2) 4920757 28 21 28 7 11 6 6 2 3 0 0.353 0.981 1.000 145 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(4), CS(1), MDH1(1), ME1(1), PC(6), SLC25A1(1) 2343056 14 12 14 6 5 1 1 3 4 0 0.784 0.984 1.000 146 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(5), IL22RA1(4), JAK1(4), JAK2(3), JAK3(4), STAT1(2), STAT3(1), STAT5A(3), STAT5B(2), TYK2(2) 4705775 30 21 29 7 14 7 2 3 4 0 0.354 0.985 1.000 147 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACYP1(1), EHHADH(2), HADHA(3), SDHB(2) 1973624 8 7 8 3 3 0 2 2 1 0 0.711 0.985 1.000 148 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(3), ALPL(3), ALPP(2), ALPPL2(1), GCH1(1) 1677869 10 8 10 5 4 0 3 1 2 0 0.717 0.985 1.000 149 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(1), CNR2(1), DNMT1(9), PTGDR(2), PTGFR(2), PTGIR(1), TBXA2R(1) 2838495 17 12 17 6 9 2 2 2 2 0 0.479 0.986 1.000 150 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(7), ALOX15(2), ALOX15B(1), ALOX5(3), DPEP1(1), GGT1(2), LTA4H(1), PLA2G6(3), PTGIS(3), PTGS1(1), PTGS2(2), TBXAS1(2) 3880223 28 21 28 6 15 6 1 4 2 0 0.178 0.987 1.000 151 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(2), JAK1(4), JAK2(3), JAK3(4), PIAS3(4), PTPRU(1), SRC(2), STAT3(1) 3869007 21 14 21 5 11 3 2 2 3 0 0.313 0.987 1.000 152 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(1), CCNB1(1), CCNE1(2), CCNH(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(2), RBL1(2), TFDP1(1) 4055857 13 13 13 2 8 0 1 2 2 0 0.232 0.987 1.000 153 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(5), FOS(1), HRAS(1), IL6ST(3), JAK1(4), JAK2(3), JAK3(4), PTPN11(2), RAF1(2), SHC1(1), SOS1(3), SRF(1), STAT3(1) 6053924 31 24 31 7 10 3 5 5 8 0 0.298 0.988 1.000 154 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 FUT2(2), GBGT1(1), GLA(1), NAGA(1) 2700577 5 5 5 1 3 0 0 1 1 0 0.457 0.988 1.000 155 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 CBS(1), CTH(2), MUT(1) 1241432 4 4 4 2 3 0 1 0 0 0 0.802 0.988 1.000 156 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(1), AKT2(3), AKT3(1), BPNT1(2), PIK3CA(2), PIK3CD(1), PTEN(5), PTK2B(1), RBL2(4), SHC1(1), SOS1(3) 5139696 24 20 24 6 4 1 8 4 7 0 0.540 0.989 1.000 157 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(1), GAD1(4), HDC(2), PNMT(1), TPH1(2) 1531680 10 9 10 7 8 0 1 0 1 0 0.912 0.990 1.000 158 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 IARS(1), LARS(4), LARS2(1) 2520799 6 6 6 2 2 0 1 1 2 0 0.881 0.990 1.000 159 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(1), CDC25C(1), CSK(1), PTPRA(1), SRC(2) 2337292 6 6 6 2 2 2 1 0 1 0 0.724 0.990 1.000 160 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA2(1), ANXA3(1), ANXA4(2), ANXA5(1), ANXA6(2), CYP11A1(2), EDNRB(3), HSD11B1(1), PLA2G4A(3), PTGDR(2), PTGFR(2), PTGIR(1), PTGIS(3), PTGS1(1), PTGS2(2), SCGB1A1(1), TBXAS1(2) 5198367 30 24 30 8 14 2 3 6 5 0 0.291 0.990 1.000 161 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3G(1), CD4(2), PTPRC(2), ZAP70(2) 2274487 7 6 7 3 4 1 0 0 2 0 0.843 0.991 1.000 162 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS1(1), ALAS2(2), GATA1(5), UROD(1) 2027039 9 9 9 8 4 0 3 0 2 0 0.977 0.991 1.000 163 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), EHHADH(2), HADHA(3) 3079349 20 16 20 6 10 1 3 6 0 0 0.450 0.991 1.000 164 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QB(1), C1R(2), C1S(1), C2(2), C3(3), C5(1), C6(2), C7(2), C8A(1) 4446148 15 11 15 3 9 2 1 3 0 0 0.325 0.992 1.000 165 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD3G(1), ICAM1(1), ITGAL(3), ITGB2(3), PTPRC(2) 2687387 11 9 11 6 4 0 2 2 3 0 0.889 0.992 1.000 166 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BIRC3(1), FADD(1), RIPK1(1), TNF(1), TNFRSF1B(1), TRADD(1), TRAF2(1) 2138309 7 6 7 3 1 2 1 1 2 0 0.874 0.992 1.000 167 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL1(1), FOSL2(1), IFNAR1(2), NFKB1(3), RELA(2) 2794431 10 8 10 4 3 2 1 0 4 0 0.825 0.993 1.000 168 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(2), NR1H3(1), NR1H4(1), RXRA(2) 1370574 6 5 6 3 4 0 0 1 1 0 0.727 0.993 1.000 169 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(3), CREBBP(5), EP300(11), IKBKB(3), IL1B(1), MAP2K3(2), MAP3K14(2), MAP3K7(1), NFKB1(3), NFKBIA(2), NR3C1(2), RELA(2), TGFBR1(1), TGFBR2(1), TLR2(2), TNF(1) 7514794 42 29 42 9 14 6 7 6 8 1 0.357 0.993 1.000 170 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(3), CREBBP(5), EP300(11), FADD(1), IKBKB(3), NFKB1(3), NFKBIA(2), RELA(2), RIPK1(1), TNF(1), TNFRSF1B(1), TRADD(1) 5659937 34 25 34 8 12 4 5 4 9 0 0.476 0.993 1.000 171 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(5), EP300(11), IL2RG(1), IL7R(1), JAK1(4), JAK3(4), NMI(1), PIK3CA(2), PIK3R1(3), PTK2B(1), STAT5A(3), STAT5B(2) 7077946 38 28 38 7 16 2 6 5 9 0 0.234 0.994 1.000 172 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSA(1), GOT1(2), GOT2(2), PAH(2), YARS2(1) 2196060 8 8 8 4 3 1 0 2 2 0 0.879 0.994 1.000 173 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 FOS(1), HRAS(1), NFKB1(3), NFKBIA(2), PLCB1(2), RAF1(2), RELA(2), TNF(1) 3907580 14 11 14 4 3 2 1 3 5 0 0.734 0.994 1.000 174 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(2), FOS(1), HRAS(1), JAK2(3), RAF1(2), SHC1(1), SOS1(3), STAT5A(3), STAT5B(2) 4481043 18 13 18 4 7 3 1 1 6 0 0.486 0.994 1.000 175 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD3G(1), CD4(2), ICAM1(1), ITGAL(3), ITGB2(3), PTPRC(2) 2826825 13 10 13 5 6 0 2 2 3 0 0.701 0.994 1.000 176 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(5), FOS(1), HRAS(1), IL2RA(1), IL2RB(3), IL2RG(1), JAK1(4), JAK3(4), RAF1(2), SHC1(1), SOS1(3), STAT5A(3), STAT5B(2), SYK(2) 5952946 33 22 33 8 16 1 3 4 9 0 0.313 0.995 1.000 177 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(6), CAPN2(5), EP300(11), NFATC1(1), NFATC2(3), PPP3CA(3), PPP3CB(1) 6126239 30 23 29 7 15 2 4 3 6 0 0.448 0.995 1.000 178 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(2), NFYC(1) 1674889 3 3 3 3 1 0 1 0 1 0 0.975 0.995 1.000 179 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(3), IFNGR1(1), IL12RB1(3), IL12RB2(1), IL2RA(1), IL4R(1) 3199690 10 9 10 6 4 1 2 0 3 0 0.965 0.996 1.000 180 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP2(1), ACP5(1), ACPP(2), ACPT(1), ALPI(3), ALPL(3), ALPP(2), ALPPL2(1), CYP2A13(3), CYP2A6(3), CYP2A7(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2D6(1), CYP2F1(1), CYP3A4(2), CYP3A7(1), CYP4F8(1), CYP51A1(3) 7406185 33 25 33 8 15 2 9 2 5 0 0.225 0.996 1.000 181 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(5), FOS(1), HRAS(1), IGF1R(4), IRS1(1), PIK3CA(2), PIK3R1(3), PTPN11(2), RAF1(2), RASA1(2), SHC1(1), SOS1(3), SRF(1) 6240224 28 23 28 9 8 2 5 4 9 0 0.694 0.996 1.000 182 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1L(2), BNIP1(1), SEC22B(1), SNAP29(1), STX10(3), STX11(1), STX12(1), STX17(1), STX18(1), STX2(2), STX4(1), STX5(1), TSNARE1(1), USE1(1), VAMP2(1), VTI1B(1) 4246661 20 19 20 5 9 1 6 2 2 0 0.263 0.996 1.000 183 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 TAX1BP3(1), UBE2C(1), UBE2G1(1), UBE2I(1), UBE2J2(1), UBE2L3(2), UBE2N(2), UBE3A(2) 2652208 11 10 11 4 7 0 1 3 0 0 0.682 0.996 1.000 184 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 CHKA(1), PCYT1A(2), PEMT(3), SLC18A3(2) 1770595 8 6 8 4 5 1 1 0 1 0 0.760 0.997 1.000 185 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(3), B4GALT5(1), GALNT10(2), GALNT11(2), GALNT14(2), GALNT2(5), GALNT3(1), GALNT4(1), GALNT5(2), GALNT6(3), GALNT7(1), GALNT9(1), GALNTL5(1), GCNT3(2), GCNT4(1), OGT(2), ST6GALNAC1(1), WBSCR17(4) 8154530 35 27 33 5 14 1 4 7 9 0 0.0807 0.997 1.000 186 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(1), MMP14(1), RECK(1), TIMP2(1) 1912138 4 4 4 4 3 0 0 0 1 0 0.969 0.997 1.000 187 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(1), CD3G(1), HLA-A(1), ICAM1(1), ITGAL(3), ITGB2(3), PRF1(2) 2201598 12 11 12 5 6 0 2 3 0 1 0.717 0.997 1.000 188 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(1), ARHGAP5(3), CASP1(1), CASP10(2), CASP9(2), PRF1(2) 3226782 11 10 11 6 5 0 1 2 3 0 0.945 0.997 1.000 189 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 FOS(1), KEAP1(2), NFE2L2(6) 2279248 9 9 9 4 2 3 0 2 2 0 0.860 0.997 1.000 190 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA6(1), PSMA7(1), PSMB1(2), PSMB10(1), PSMB4(1) 2210626 7 7 7 3 2 1 2 1 1 0 0.800 0.997 1.000 191 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(5), EP300(11), ESR1(1), PELP1(2), SRC(2) 3778221 21 17 21 6 10 2 3 2 4 0 0.637 0.997 1.000 192 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(3), C5(1), C6(2), C7(2), C8A(1) 3171740 9 7 9 2 5 0 1 3 0 0 0.466 0.997 1.000 193 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(3), MAP3K14(2), NFKB1(3), RELA(2), TNFRSF13B(1), TRAF2(1), TRAF5(2) 3691812 14 12 14 4 6 1 1 1 5 0 0.648 0.997 1.000 194 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(1), F2R(1), F2RL3(1), GNB1(2), HRAS(1), ITGA1(3), ITGB1(5), PLA2G4A(3), PLCB1(2), PTGS1(1), PTK2(1), RAF1(2), SRC(2), SYK(2), TBXAS1(2) 6136136 29 24 29 7 10 3 4 6 6 0 0.399 0.997 1.000 195 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(1), ESR2(2), ITPKA(3), PLCB1(2), PLCB2(4), TRH(2), VIP(1) 2803878 15 11 15 6 8 1 2 1 3 0 0.724 0.997 1.000 196 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(3), IKBKB(3), MAP3K1(7), MAP3K14(2), NFKB1(3), NFKBIA(2), RELA(2), TNFAIP3(2) 4609244 24 20 24 5 10 2 4 3 5 0 0.338 0.997 1.000 197 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(5), EPOR(3), FOS(1), HRAS(1), JAK2(3), PLCG1(1), RAF1(2), SHC1(1), SOS1(3), STAT5A(3), STAT5B(2) 5467347 25 18 25 6 9 2 3 4 7 0 0.456 0.998 1.000 198 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(2), JAK1(4), JAK2(3), JAK3(4), PIAS1(2), PIAS3(4), PTPRU(1) 3491043 20 15 20 6 9 2 2 3 4 0 0.538 0.998 1.000 199 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(2), CSF1R(2), EGF(2), EGFR(2), MET(16), PDGFRA(1), SH3GLB2(1), SH3KBP1(3), SRC(2) 4901919 31 26 29 9 7 2 7 12 3 0 0.554 0.998 1.000 200 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 BDH2(1), HMGCL(1), OXCT1(1) 1831848 3 3 3 2 1 0 0 1 1 0 0.911 0.998 1.000 201 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(2), JAK1(4), STAT1(2), TYK2(2) 2741554 10 9 9 4 5 0 1 2 2 0 0.712 0.998 1.000 202 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(2), ARFGEF2(3), CLTA(1), CLTB(1), COPA(3), GBF1(6), GPLD1(3), KDELR1(1), KDELR3(2) 4091798 22 21 22 8 9 2 2 5 4 0 0.805 0.998 1.000 203 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IL10(1), IL16(2), IL9(1), LTA(1), TNF(1) 2499051 6 5 6 3 2 0 1 1 2 0 0.885 0.998 1.000 204 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2A(4), POLR2B(4), POLR2F(1), POLR2I(1), POLR2J(1), POLRMT(2) 3417727 15 14 15 7 2 2 6 2 3 0 0.908 0.998 1.000 205 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), CAMK1G(1), HDAC9(1), MEF2A(2) 2028158 6 6 6 4 1 1 2 1 1 0 0.917 0.998 1.000 206 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(5), DAXX(2), HRAS(1), PAX3(1), PML(1), SP100(2), TNF(1), TNFRSF1B(1), TP53(7) 4811471 21 18 21 5 6 2 4 3 6 0 0.499 0.998 1.000 207 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(5), GNAS(3), GNB1(2), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1) 2461382 15 9 15 6 7 1 3 2 2 0 0.842 0.998 1.000 208 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(3), GNA12(1), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAR2A(1), PRKAR2B(1) 2542111 9 6 9 5 4 1 0 2 2 0 0.936 0.998 1.000 209 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(1), BAD(1), CASP9(2), CHUK(3), NFKB1(3), NFKBIA(2), PIK3CA(2), PIK3R1(3), RELA(2) 3561230 19 16 19 8 6 1 5 3 4 0 0.900 0.998 1.000 210 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), BFAR(1), BRAF(2), CAMP(1), CREB3(3), RAF1(2), SNX13(3), SRC(2) 2864638 15 13 15 7 4 2 2 5 2 0 0.946 0.998 1.000 211 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS1(1), ALAS2(2), PPOX(1), UROD(1) 1932796 5 5 5 8 2 0 2 0 1 0 0.998 0.998 1.000 212 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(3), DHCR7(1), FDFT1(1), FDPS(1), HMGCR(4), LSS(3), MVD(1), MVK(2), PMVK(1), SQLE(1) 3362703 18 13 18 6 9 4 2 0 3 0 0.647 0.998 1.000 213 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 JUNB(2), MAF(1), MAP2K3(2), NFATC1(1), NFATC2(3), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1) 3076285 14 11 14 6 3 2 3 3 3 0 0.852 0.998 1.000 214 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), ASNS(2), CA1(1), CA5A(1), CA5B(1), CA6(1), CA7(2), CA8(1), CA9(2), CPS1(2), CTH(2), GLS(5), GLS2(1), GLUL(2) 4782839 24 21 24 7 10 2 2 4 6 0 0.600 0.999 1.000 215 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(1), ACO2(3), CS(1), HAO1(3), HAO2(1), HYI(1), MDH1(1), MTHFD1(3), MTHFD1L(1), MTHFD2(1) 3219335 16 14 16 5 7 0 2 4 3 0 0.614 0.999 1.000 216 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(1), BAD(1), HRAS(1), IGF1R(4), IRS1(1), PIK3CA(2), PIK3R1(3), RAF1(2), SHC1(1), SOS1(3) 4756555 19 16 19 9 5 1 5 3 5 0 0.913 0.999 1.000 217 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(1), DPM2(1), HRAS(1), KLK2(1), MAP2K2(1), RAF1(2) 2095150 7 7 7 5 4 0 0 2 1 0 0.918 0.999 1.000 218 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), APAF1(1), CASP9(2), DAXX(2), FASLG(2), MAPKAPK3(1), TNF(1) 2844601 10 7 10 4 3 0 3 1 3 0 0.798 0.999 1.000 219 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(1), CCNE1(2), CDK2(1), CDK4(1), CDKN1A(1), HRAS(1), NFKB1(3), NFKBIA(2), PAK1(1), PIK3CA(2), PIK3R1(3), RAC1(1), RAF1(2), RELA(2), TFDP1(1) 5109106 24 21 24 6 9 1 4 4 6 0 0.536 0.999 1.000 220 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(5), GPT(2), LDHB(1) 2264562 8 7 8 6 3 0 1 3 1 0 0.970 0.999 1.000 221 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(1), CFTR(3), GNAS(3), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), SLC9A3R1(1) 3327956 13 10 13 8 4 2 1 3 3 0 0.983 0.999 1.000 222 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(1), ACTR3(1), ARPC2(1), CDC42(1), PAK1(1), PDGFRA(1), PIK3CA(2), PIK3R1(3), RAC1(1) 3375095 12 10 12 7 3 0 4 2 3 0 0.975 0.999 1.000 223 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(1), BAD(1), CASP9(2), CDC42(1), CHUK(3), HRAS(1), NFKB1(3), PIK3CA(2), PIK3R1(3), RAC1(1), RAF1(2), RALBP1(4), RALGDS(1), RELA(2), RHOA(2) 4866217 29 20 29 8 13 1 6 3 6 0 0.453 0.999 1.000 224 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(5), FOS(1), HRAS(1), INS(3), INSR(3), IRS1(1), PIK3CA(2), PIK3R1(3), PTPN11(2), RAF1(2), RASA1(2), SHC1(1), SLC2A4(1), SOS1(3), SRF(1) 6428798 31 23 31 9 11 2 6 4 8 0 0.573 0.999 1.000 225 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(6), CDKN2A(2), MDM2(1), PIK3CA(2), PIK3R1(3), POLR1A(1), POLR1B(2), POLR1C(1), POLR1D(1), RAC1(1), TP53(7), TWIST1(1) 5120907 28 21 28 7 10 2 6 5 5 0 0.456 0.999 1.000 226 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK4(4), EIF2B5(1), EIF2S3(1), EIF5(1), GSK3B(2), PPP1CA(2) 2906434 11 8 11 9 5 0 2 2 2 0 0.997 0.999 1.000 227 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(2), IFNGR1(1), JAK1(4), JAK2(3), PTPRU(1), STAT1(2) 2878754 13 12 13 5 5 3 1 2 2 0 0.792 0.999 1.000 228 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS1(1), DHRS2(1), PON2(2), PON3(2), RDH11(2), RDH13(1) 2267437 9 8 9 7 6 1 0 1 1 0 0.970 0.999 1.000 229 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(1), IL2RG(1), IL4R(1), IRS1(1), JAK1(4), JAK3(4), SHC1(1), STAT6(4) 3747544 17 15 17 8 7 1 3 2 4 0 0.778 0.999 1.000 230 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(1), ACO2(3), CS(1), HAO1(3), HAO2(1), HYI(1), MDH1(1), MTHFD1(3), MTHFD1L(1), MTHFD2(1) 3376044 16 14 16 5 7 0 2 4 3 0 0.604 0.999 1.000 231 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(3), FADD(1), IKBKB(3), IL1R1(1), MAP3K1(7), MAP3K14(2), MAP3K7(1), NFKB1(3), NFKBIA(2), RELA(2), RIPK1(1), TLR4(3), TNF(1), TNFAIP3(2), TNFRSF1B(1), TRADD(1) 6181577 34 26 34 9 12 4 6 4 7 1 0.502 0.999 1.000 232 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(2), DLL1(1), NOTCH1(8), PSEN1(2) 2379737 13 12 13 5 5 2 4 1 1 0 0.647 0.999 1.000 233 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(1), IFNGR1(1), IKBKB(3), JAK2(3), NFKB1(3), NFKBIA(2), RELA(2), TNF(1), TNFRSF1B(1), TP53(7), USH1C(2), WT1(1) 4633380 27 23 27 9 8 6 3 5 5 0 0.782 0.999 1.000 234 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(5), ACACB(5), FASN(9), MCAT(2), OLAH(1), OXSM(2) 4119084 24 21 24 8 11 1 7 2 3 0 0.447 0.999 1.000 235 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 GOT1(2), GOT2(2), PAH(2) 2086042 6 6 6 6 3 0 0 2 1 0 0.975 0.999 1.000 236 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 IL9(1), TGFB1(2) 2113684 3 2 3 4 1 0 0 1 1 0 0.974 0.999 1.000 237 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), FDFT1(1), FDPS(1), HMGCR(4), LSS(3), MVD(1), MVK(2), NQO2(2), PMVK(1), SQLE(1) 2830258 17 12 17 6 8 4 2 1 2 0 0.625 0.999 1.000 238 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(1), ATM(6), CCNE1(2), CDK2(1), CDK4(1), CDKN1A(1), MDM2(1), TP53(7) 4565155 20 18 20 6 9 2 1 4 4 0 0.588 0.999 1.000 239 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ACTR2(1), ACTR3(1), ARPC2(1), CDC42(1), RAC1(1), WASF1(1) 2057652 7 6 7 5 2 1 2 1 1 0 0.961 0.999 1.000 240 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA6(1), PSMA7(1), PSMB1(2), PSMB4(1), RPN1(1), RPN2(1), UBE3A(2) 3279896 10 9 10 4 3 1 2 2 2 0 0.812 0.999 1.000 241 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(1), FHL5(1), GNAS(3), XPO1(3) 2424362 8 7 8 5 3 1 2 1 1 0 0.975 0.999 1.000 242 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA6(1), PSMA7(1), PSMB1(2), PSMB4(1), PSMD1(1), PSMD11(1), PSMD12(1), PSMD2(3), PSMD6(1) 4038292 13 10 13 7 6 1 2 1 3 0 0.936 0.999 1.000 243 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), JAK1(4), PTPRU(1), STAT1(2), TYK2(2) 3159231 11 9 10 6 6 0 1 2 2 0 0.842 0.999 1.000 244 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(2), AKT1(1), ATM(6), CDKN1A(1), CPB2(1), CSNK1A1(1), CSNK1D(1), HIC1(1), HIF1A(2), IGFBP3(1), MDM2(1), TP53(7) 5262749 25 21 25 9 11 2 4 4 3 1 0.700 1.000 1.000 245 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(5), ALDH18A1(1), ARG1(1), ARG2(1), CKB(2), CPS1(2), GATM(3), NAGS(1), OAT(1), OTC(1), SMS(1) 4473133 19 17 19 7 10 3 0 2 4 0 0.726 1.000 1.000 246 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 CAT(2), EPX(3), MPO(3), MTHFR(1), PRDX6(2), SHMT1(1), SHMT2(3), TPO(1) 2941343 16 15 15 6 6 2 4 3 1 0 0.615 1.000 1.000 247 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 LDLR(2), MBTPS1(1), MBTPS2(1), SCAP(3), SREBF1(3), SREBF2(3) 3107600 13 13 13 5 3 4 0 4 2 0 0.773 1.000 1.000 248 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), ACTN2(1), BCAR1(2), CSK(1), CTNNA1(5), CTNNA2(2), PTK2(1), PXN(1), SRC(2) 4889837 16 15 16 6 6 1 2 2 5 0 0.748 1.000 1.000 249 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(2), CSF1(1), IL10(1), LTA(1), PDGFA(1), TGFB1(2), TNF(1) 3387860 9 6 9 3 6 0 0 0 3 0 0.587 1.000 1.000 250 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(5), FOS(1), HRAS(1), JAK2(3), MPL(2), PIK3CA(2), PIK3R1(3), PLCG1(1), RAF1(2), RASA1(2), SHC1(1), SOS1(3), STAT1(2), STAT3(1), STAT5A(3), STAT5B(2), THPO(2) 7550316 36 24 36 9 13 2 5 6 10 0 0.524 1.000 1.000 251 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 CAT(2), EPX(3), MPO(3), PRDX2(1), PRDX6(2), SHMT1(1), SHMT2(3), TPO(1) 3000805 16 15 15 6 5 2 4 4 1 0 0.637 1.000 1.000 252 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(1), CCNH(1), CDC25C(1), SHH(1), XPO1(3) 2192221 7 6 7 3 3 0 2 2 0 0 0.823 1.000 1.000 253 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 ICAM1(1), ITGAL(3), ITGAM(4), ITGB2(3), SELE(1), SELL(2) 2666711 14 13 14 7 6 1 4 2 1 0 0.828 1.000 1.000 254 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(1), CREBBP(5), EP300(11), MAP3K7(1), SKIL(1), TGFB1(2), TGFBR1(1), TGFBR2(1) 6464735 23 18 23 7 7 2 5 3 5 1 0.754 1.000 1.000 255 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(1), F2(1), F2R(1), F5(3), F7(2), FGA(1), FGB(1), PROS1(2), TFPI(1) 4135651 13 13 13 6 5 0 4 1 3 0 0.913 1.000 1.000 256 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(1), CAT(2), HRAS(1), IGF1R(4), PIK3CA(2), PIK3R1(3), SHC1(1), SOD2(1) 3340025 15 14 14 9 8 1 3 1 2 0 0.968 1.000 1.000 257 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(3), IKBKB(3), LTA(1), MAP3K1(7), MAP3K14(2), NFKB1(3), NFKBIA(2), RELA(2), RIPK1(1), TNFAIP3(2), TNFRSF1B(1), TRAF1(2), TRAF2(1) 5691354 30 22 30 7 13 4 5 3 5 0 0.341 1.000 1.000 258 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 DLG4(3), F2(1), F2RL2(1), F2RL3(1), MAP2K5(3), MAPK7(3), MYEF2(1), PLD1(2), PLD2(1), PTK2(1), RAF1(2), RASAL1(4), SRC(2), VAV1(1) 6983507 26 22 25 7 10 4 5 5 2 0 0.389 1.000 1.000 259 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(6), ATR(4), CDC25C(1), CHEK1(2), CHEK2(2), TP53(7) 3999160 22 17 22 8 10 4 2 4 2 0 0.847 1.000 1.000 260 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(6), CDC25C(1), CDK2(1), CDK4(1), CHEK1(2), MYT1(7), TP53(7), WEE1(1) 4438320 26 21 26 8 14 2 1 6 3 0 0.598 1.000 1.000 261 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(2), AMT(1), ATIC(1), GART(3), MTHFD1(3), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(2), SHMT1(1), SHMT2(3), TYMS(1) 4800582 20 17 20 6 6 2 4 6 2 0 0.571 1.000 1.000 262 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(2), GNAS(3), GNB1(2), HRAS(1), LIMK1(6), NOX1(2), PIK3C2G(6), PLCB1(2), PPP1R12B(1), PTK2(1), RAF1(2), ROCK2(4) 6406393 32 22 32 8 13 4 6 6 3 0 0.428 1.000 1.000 263 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(4), ATP6V1H(1), SHMT1(1) 3803757 17 14 17 5 8 5 2 1 1 0 0.487 1.000 1.000 264 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(4), ATP6V1H(1), SHMT1(1) 3803757 17 14 17 5 8 5 2 1 1 0 0.487 1.000 1.000 265 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(4), ATP6V1H(1), SHMT1(1) 3803757 17 14 17 5 8 5 2 1 1 0 0.487 1.000 1.000 266 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(1), CMAS(1), CYB5R1(3), GFPT1(3), GNE(1), HK1(1), HK2(2), MTMR2(2), MTMR6(4), NAGK(2), NANS(2), NPL(4), PGM3(1), PHPT1(1), RENBP(2), UAP1(2) 7267695 32 21 31 9 19 1 4 5 3 0 0.359 1.000 1.000 267 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(1), CD38(1), ENPP1(6), ENPP3(1), NADSYN1(1), NMNAT2(1), NNT(2) 3680640 13 9 13 6 6 1 0 4 2 0 0.847 1.000 1.000 268 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(2), EGF(2), EGFR(2), HRAS(1), PTPRB(3), RAF1(2), RASA1(2), SHC1(1), SOS1(3), SPRY2(1), SPRY4(2), SRC(2) 6303865 23 18 23 6 9 2 2 5 5 0 0.489 1.000 1.000 269 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 FOS(1), POLR2A(4), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1) 3259252 10 7 10 7 3 0 3 1 3 0 0.957 1.000 1.000 270 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), CHUK(3), IKBKB(3), MAP3K1(7), MAP3K5(1), MAP4K5(2), NFKB1(3), NFKBIA(2), RELA(2), TRAF2(1) 4931442 25 18 25 9 15 1 2 2 5 0 0.733 1.000 1.000 271 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(1), GLB1(1), GNS(1), IDUA(5), LCT(5), NAGLU(4) 3684891 17 14 14 8 7 0 2 6 2 0 0.900 1.000 1.000 272 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(1), CR2(4), FCGR2B(2), ICAM1(1), ITGAL(3), ITGB2(3), PTPRC(2) 3824168 16 15 16 7 7 1 3 3 2 0 0.843 1.000 1.000 273 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(1), BIRC3(1), CASP10(2), CASP9(2), PRF1(2), SCAP(3), SREBF1(3), SREBF2(3) 4692653 17 15 17 7 6 4 1 3 3 0 0.844 1.000 1.000 274 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(5), MAP2(1), PPP1CA(2), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAR2A(1), PRKAR2B(1), PRKCE(2) 4473253 15 12 15 8 7 0 3 2 3 0 0.946 1.000 1.000 275 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1(2), CAMK1G(1), CAMK2A(4), CAMK2B(1), CAMK4(1), CAMKK1(5), CAMKK2(2) 2968512 16 12 16 7 7 2 4 2 1 0 0.724 1.000 1.000 276 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(6), APOC3(1), CETP(1), CYP7A1(2), DGAT1(2), HMGCR(4), LCAT(2), LDLR(2), LPL(1), LRP1(14), SCARB1(1) 6910626 36 24 35 9 18 6 4 4 4 0 0.174 1.000 1.000 277 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(1), BIRC3(1), CASP1(1), CASP10(2), CASP4(2), CASP9(2), LMNA(3), LMNB2(1), PRF1(2) 4872496 15 12 15 8 7 0 2 2 4 0 0.922 1.000 1.000 278 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT3(2), B4GALT7(1), CHPF(2), CHST11(1), CHST3(1), CHST7(1), DSE(1), UST(1), XYLT1(2), XYLT2(2) 3580972 14 11 14 7 6 1 4 1 2 0 0.739 1.000 1.000 279 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(1), CD2(1), CD3G(1), CD4(2), IL12RB1(3), IL12RB2(1), JAK2(3), TYK2(2) 3741341 14 9 13 7 9 2 0 1 2 0 0.909 1.000 1.000 280 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(6), CDC25C(1), CHEK1(2), MYT1(7), WEE1(1) 3474724 17 13 17 8 12 0 0 4 1 0 0.871 1.000 1.000 281 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(1), PIK3CA(2), PIK3R1(3), PLCB1(2), PLCG1(1), VAV1(1) 3234863 10 10 10 6 1 1 4 3 1 0 0.970 1.000 1.000 282 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(3), PGAP1(5), PIGB(2), PIGF(1), PIGK(2), PIGL(1), PIGN(3), PIGO(2), PIGQ(3), PIGS(1), PIGU(1), PIGX(1) 6121761 26 22 26 6 12 4 4 4 2 0 0.237 1.000 1.000 283 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 IARS(1), IARS2(1), ILVBL(2), LARS(4), LARS2(1), VARS(3), VARS2(5) 4696305 17 16 17 5 6 1 3 4 3 0 0.630 1.000 1.000 284 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(1), AXIN1(5), CREBBP(5), EP300(11), FZD1(2), GSK3B(2), LDB1(1), LEF1(2), TRRAP(4) 8368674 33 26 33 9 15 3 5 5 5 0 0.452 1.000 1.000 285 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 AKT1(1), GNAS(3), GNB1(2), NFKB1(3), NOS3(3), NR3C1(2), PIK3CA(2), PIK3R1(3), RELA(2) 4578907 21 18 21 9 6 4 5 3 3 0 0.911 1.000 1.000 286 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(1), GNAS(3), PLCE1(2), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1) 3744348 11 8 11 8 5 1 1 2 2 0 0.991 1.000 1.000 287 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(1), CRKL(1), DOCK1(5), FOS(1), GAB1(2), HGF(1), HRAS(1), ITGA1(3), ITGB1(5), MAP2K2(1), MAP4K1(3), MET(16), PAK1(1), PIK3CA(2), PIK3R1(3), PTEN(5), PTK2(1), PTK2B(1), PTPN11(2), PXN(1), RAF1(2), RASA1(2), SOS1(3), SRC(2), STAT3(1) 11278064 66 49 64 13 10 3 13 20 20 0 0.245 1.000 1.000 288 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 ARSB(1), ARSD(2), ARSE(3), CYP11B1(2), HSD11B1(1), SRD5A1(1), STS(4), SULT1E1(2), UGT1A1(1), UGT1A3(1), UGT1A5(2), UGT1A9(2) 6881742 22 20 22 9 10 1 2 4 5 0 0.800 1.000 1.000 289 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(1), DAB1(1), RELN(6), VLDLR(2) 3519876 10 9 9 6 6 0 3 0 1 0 0.941 1.000 1.000 290 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ACTR2(1), ACTR3(1), ARPC2(1), NCKAP1(2), NTRK1(5), PIR(1), PSMA7(1), RAC1(1), WASF1(1), WASF2(1) 3856168 16 12 16 9 5 3 4 2 2 0 0.967 1.000 1.000 291 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(1), BAK1(1), BID(2), BIK(3), BIRC3(1), CASP9(2), DIABLO(1), ENDOG(1) 3424172 12 11 12 5 6 0 3 2 1 0 0.766 1.000 1.000 292 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC10(1), ANAPC2(2), ANAPC4(1), ANAPC5(4), BTRC(1), CDC16(1), CDC20(3), CDC27(7), CUL1(4), CUL2(2), CUL3(7), FBXW11(2), FBXW7(3), FZR1(4), RBX1(1), SKP1(1), SKP2(1), UBA1(4), UBE2C(1), VHL(2), WWP1(6), WWP2(3) 10201850 61 47 61 12 21 6 13 10 11 0 0.203 1.000 1.000 293 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(2), EGFR(2), MAP3K1(7), NCOR2(8), RXRA(2), THRA(1), THRB(1) 4415302 23 15 22 9 17 1 1 1 3 0 0.656 1.000 1.000 294 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(1), ALDH4A1(3), CAD(5), CPS1(2), EPRS(4), GAD1(4), GAD2(2), GCLC(3), GFPT1(3), GLS(5), GLS2(1), GLUL(2), GMPS(1), GOT1(2), GOT2(2), GPT(2), GSS(1), NADSYN1(1), PPAT(2), QARS(1) 8384983 47 34 47 12 20 2 7 11 7 0 0.301 1.000 1.000 295 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 GLB1(1), LCT(5), SLC33A1(1), ST6GALNAC4(1), ST6GALNAC5(2), ST6GALNAC6(2), ST8SIA5(2) 4146724 14 11 14 7 7 0 4 1 2 0 0.848 1.000 1.000 296 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(2), APC(1), AXIN1(5), BTRC(1), DLL1(1), FZD1(2), GSK3B(2), NOTCH1(8), PSEN1(2) 5443793 24 21 24 8 11 3 6 2 2 0 0.559 1.000 1.000 297 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(5), CPT1A(2), LEP(2), LEPR(2), PRKAB1(1), PRKAG1(1), PRKAG2(3) 3636322 16 11 16 5 10 1 2 2 1 0 0.584 1.000 1.000 298 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(1), POLR1B(2), POLR1C(1), POLR1D(1), POLR2A(4), POLR2B(4), POLR2F(1), POLR2I(1), POLR2J(1), POLR3A(3), POLR3B(3), POLR3GL(1) 5910906 23 19 23 8 7 2 9 1 4 0 0.698 1.000 1.000 299 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(2), AASDHPPT(1), AASS(2), ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), DLST(1), DOT1L(6), EHHADH(2), EHMT1(3), EHMT2(7), HADHA(3), PLOD1(2), PLOD2(2), PLOD3(1), SHMT1(1), SHMT2(3) 9322414 51 36 51 12 20 6 13 8 4 0 0.167 1.000 1.000 300 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CDKN1A(1), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), PLCG1(1), PPP3CA(3), PPP3CB(1) 5252646 17 14 17 6 10 1 2 1 3 0 0.769 1.000 1.000 301 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 DBH(1), DDC(3), GAD1(4), GAD2(2), HDC(2), MAOA(2), PAH(2), PNMT(1), SLC18A3(2), TPH1(2) 3672638 21 17 21 9 14 0 3 3 1 0 0.650 1.000 1.000 302 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(4), ABCC2(4), ABCG2(2), BCHE(2), CES1(1), CYP3A4(2), UGT1A1(1), UGT1A3(1), UGT1A5(2), UGT1A9(2) 5732107 21 20 21 8 7 2 3 6 3 0 0.793 1.000 1.000 303 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(3), ARG1(1), ARG2(1), ASS1(4), CKB(2), CPS1(2), EPRS(4), GATM(3), GLUD2(11), GOT1(2), GOT2(2), LAP3(3), NOS1(4), NOS3(3), OAT(1), OTC(1), P4HA1(1), PARS2(1), PRODH(1), PYCR2(2), RARS(1), RARS2(3) 9133907 56 40 49 14 27 5 5 12 7 0 0.178 1.000 1.000 304 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CLOCK(3), CRY1(1), CRY2(1), CSNK1D(1), CSNK1E(3), NR1D1(1), PER1(2), PER2(3), PER3(3) 4345115 18 16 18 9 7 0 6 3 2 0 0.913 1.000 1.000 305 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(2), ABCB11(5), ABCB4(4), ABCC1(4), ABCC3(3), GSTP1(2) 3620024 20 16 20 8 10 1 6 2 1 0 0.552 1.000 1.000 306 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CCL4(1), CCR5(1), FOS(1), PLCG1(1), PTK2B(1) 3466374 5 4 5 7 2 0 1 1 1 0 0.998 1.000 1.000 307 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG7(1), BECN1(1), IFNA16(1), IFNA2(1), INS(3), PIK3C3(1), PIK3R4(3), ULK1(1), ULK2(4), ULK3(1) 5363163 17 16 17 8 10 1 2 2 2 0 0.910 1.000 1.000 308 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(3), CS(1), DLD(3), DLST(1), FH(2), IDH2(4), IDH3B(3), MDH1(1), OGDH(7), PC(6), PDHX(1), PDK3(3), PDK4(1), SDHA(4), SDHB(2), SDHD(2), SUCLA2(1), SUCLG2(1) 7198270 46 30 46 12 17 3 7 5 13 1 0.362 1.000 1.000 309 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(5), ACE2(1), AGT(3), AGTR2(1), ANPEP(5), CTSA(3), ENPEP(2), LNPEP(1), MME(2), NLN(2), THOP1(2) 5333009 27 19 27 9 15 2 4 5 1 0 0.474 1.000 1.000 310 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(1), BST1(2), CD38(1), ENPP1(6), ENPP3(1), NADK(2), NADSYN1(1), NMNAT2(1), NNT(2), NT5C1A(1), NT5C1B(1), NT5C2(1) 5435046 20 13 19 7 8 1 3 5 3 0 0.639 1.000 1.000 311 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(1), DCXR(2), RPE(2), UCHL1(1), UGDH(1), UGT1A1(1), UGT1A3(1), UGT1A5(2), UGT1A9(2) 4421983 13 13 13 5 4 3 1 4 1 0 0.811 1.000 1.000 312 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(2), CARS(1), DARS(3), EPRS(4), GARS(1), IARS(1), KARS(2), LARS(4), LARS2(1), MARS(3), MARS2(1), NARS(1), QARS(1), RARS(1) 8051628 26 20 26 8 12 0 4 5 5 0 0.665 1.000 1.000 313 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(4), ATP6V1H(1), FDXR(2), SHMT1(1) 4047315 19 16 19 7 8 5 3 2 1 0 0.644 1.000 1.000 314 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), FUT2(2), FUT4(2), FUT6(1), FUT7(1) 4065392 10 9 10 5 5 1 1 2 1 0 0.825 1.000 1.000 315 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASNS(2), CA1(1), CA13(2), CA5A(1), CA5B(1), CA6(1), CA7(2), CA8(1), CA9(2), CPS1(2), CTH(2), GLS(5), GLS2(1), GLUD2(11), GLUL(2) 5347059 37 32 31 10 15 2 3 11 6 0 0.458 1.000 1.000 316 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(1), GABBR1(2), GPRC5B(2), GPRC5C(1), GPRC5D(1), GRM2(5), GRM3(1), GRM4(6), GRM5(1) 5275415 20 18 20 8 10 0 6 2 2 0 0.488 1.000 1.000 317 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), GCK(2), GFPT1(3), GNE(1), HK1(1), HK2(2), PGM3(1), RENBP(2), UAP1(2) 4296535 15 11 15 6 9 2 1 2 1 0 0.724 1.000 1.000 318 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1(2), CAMK1G(1), CAMK2A(4), CAMK2B(1), CAMK4(1), ESRRA(1), HDAC5(3), MEF2A(2), PPP3CA(3), PPP3CB(1), SLC2A4(1) 5217303 20 19 20 8 7 3 7 1 2 0 0.732 1.000 1.000 319 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 FUCA1(2), FUCA2(1), GLB1(1), LCT(5), MANBA(2), NEU1(1), NEU2(1), NEU4(2) 4221676 15 14 15 6 8 1 4 1 1 0 0.747 1.000 1.000 320 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QB(1), C1R(2), C1S(1), C2(2), C3(3), C5(1), C6(2), C7(2), C8A(1), MASP1(1), MASP2(1), MBL2(1) 5415883 18 13 18 5 10 2 2 4 0 0 0.477 1.000 1.000 321 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AOC2(3), AOC3(2), CES1(1), ESCO2(1), LIPA(3), PLA1A(1), PNPLA3(1), PPME1(1), PRDX6(2) 6379470 15 12 15 5 7 0 3 2 3 0 0.669 1.000 1.000 322 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(1), ARHGEF1(2), F2(1), F2R(1), F2RL3(1), GNA12(1), GNA13(2), GNB1(2), MAP3K7(1), PIK3CA(2), PIK3R1(3), PLCB1(2), PPP1R12B(1), PTK2B(1) 6517230 21 18 21 7 9 3 3 4 1 1 0.739 1.000 1.000 323 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(1), CD3G(1), ETV5(3), IL12RB1(3), IL12RB2(1), JAK2(3), TYK2(2) 4727718 14 9 13 9 8 2 1 2 1 0 0.976 1.000 1.000 324 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 CALCR(1), CALCRL(1), CD97(2), ELTD1(3), EMR2(2), GHRHR(1), GIPR(1), GLP1R(2), GLP2R(2), GPR64(2), LPHN1(3), LPHN2(2), LPHN3(2), VIPR2(1) 6852271 25 19 25 9 14 1 4 3 3 0 0.647 1.000 1.000 325 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASDHPPT(1), AASS(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), DLST(1), DOT1L(6), EHHADH(2), EHMT1(3), EHMT2(7), HADHA(3), HSD17B10(2), HSD17B4(1), NSD1(8), OGDH(7), OGDHL(3), PIPOX(3), PLOD1(2), PLOD2(2), PLOD3(1), RDH11(2), RDH13(1), SETD1A(4), SETDB1(5), SHMT1(1), SHMT2(3), SPCS1(1), SUV39H1(2), SUV39H2(1) 14664683 87 57 86 22 33 13 18 10 13 0 0.260 1.000 1.000 326 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(3), ARHGEF1(2), GNA12(1), GNA13(2), GNB1(2), PLCB1(2), PPP1R12B(1) 5206639 13 12 13 5 6 3 0 3 1 0 0.791 1.000 1.000 327 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACOT11(1), ACYP1(1), DHRS1(1), DHRS2(1), EHHADH(2), ESCO2(1), FN3K(1), HADHA(3), PNPLA3(1), YOD1(1) 6531271 13 11 13 8 6 0 3 2 2 0 0.968 1.000 1.000 328 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(4), AR(4), ESR1(1), ESR2(2), ESRRA(1), HNF4A(3), NR1D1(1), NR1D2(1), NR1H2(2), NR1H3(1), NR1I3(1), NR2C2(3), NR2E1(1), NR2F1(1), NR2F2(3), NR2F6(1), NR3C1(2), NR4A2(1), PGR(2), PPARD(1), RARG(2), RORA(2), RORC(3), RXRA(2), RXRB(2), RXRG(2), THRA(1), THRB(1), VDR(1) 10698359 52 36 51 12 27 4 8 7 6 0 0.147 1.000 1.000 329 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(2), ALOX12(7), ALOX15(2), ALOX5(3), CBR1(3), CYP4F2(1), CYP4F3(3), EPX(3), GGT1(2), LTA4H(1), MPO(3), PLA2G3(1), PLA2G4A(3), PLA2G6(3), PRDX2(1), PRDX6(2), PTGES2(1), PTGIS(3), PTGS1(1), PTGS2(2), TBXAS1(2), TPO(1) 7107425 50 30 50 12 21 9 7 8 5 0 0.174 1.000 1.000 330 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(2), ALOX12(7), ALOX12B(2), ALOX15(2), ALOX15B(1), ALOX5(3), CBR1(3), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP4A11(2), CYP4A22(1), CYP4F2(1), CYP4F3(3), EPHX2(2), GGT1(2), GPX1(1), GPX4(1), LTA4H(1), PLA2G12A(2), PLA2G2D(3), PLA2G3(1), PLA2G4A(3), PLA2G6(3), PTGES2(1), PTGIS(3), PTGS1(1), PTGS2(2), TBXAS1(2) 9940888 58 34 58 12 28 8 13 4 5 0 0.0555 1.000 1.000 331 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(2), CDC7(1), CDK2(1), CDT1(2), DIAPH2(2), MCM10(2), MCM2(3), MCM3(2), MCM4(3), MCM5(2), MCM6(3), MCM7(2), NACA(5), POLA2(1), POLD1(4), POLD2(2), POLD4(1), PRIM1(1), RFC1(2), RFC3(2), RFC4(1), RFC5(2), RPA1(1), RPA4(1), RPS27A(1), UBA52(2) 12832881 51 33 49 11 24 3 9 7 8 0 0.105 1.000 1.000 332 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(4), ACAA2(1), ACADL(4), ACADSB(1), ACADVL(3), ACOX1(3), ACOX3(6), ACSL1(2), ACSL4(1), ACSL5(1), ACSL6(4), ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), CPT1A(2), CPT1B(1), CPT2(1), CYP4A11(2), CYP4A22(1), EHHADH(2), HADHA(3), HADHB(1), HSD17B10(2), HSD17B4(1) 12371974 65 43 65 17 29 4 14 12 5 1 0.228 1.000 1.000 333 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(4), ACAA2(1), ACADL(4), ACADSB(1), ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), AOX1(1), BCKDHA(1), EHHADH(2), HADHA(3), HADHB(1), HIBADH(1), HMGCL(1), IVD(3), MCCC1(3), MCCC2(1), MUT(1), OXCT1(1), PCCA(2), PCCB(1) 9108636 47 32 47 13 22 1 7 11 5 1 0.375 1.000 1.000 334 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(2), CSK(1), CTLA4(2), DAG1(6), DTYMK(1), FBXW7(3), GRAP2(1), ITPKA(3), ITPKB(3), LAT(2), LCP2(3), NFAT5(3), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIL1(1), PAK1(1), PAK3(1), PAK4(2), PAK6(3), PAK7(1), PLCG1(1), PTPRC(2), RAF1(2), RASGRP1(2), RASGRP2(2), RASGRP3(1), RASGRP4(2), SOS1(3), SOS2(3), VAV1(1), ZAP70(2) 14239370 68 44 68 18 22 6 15 9 16 0 0.376 1.000 1.000 335 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(1), ADC(1), ALDH4A1(3), CAD(5), CPS1(2), EPRS(4), GAD1(4), GAD2(2), GCLC(3), GFPT1(3), GLS(5), GLS2(1), GLUD2(11), GLUL(2), GMPS(1), GOT1(2), GOT2(2), GPT(2), GSS(1), NADSYN1(1), NAGK(2), PPAT(2), QARS(1) 9987236 61 42 55 18 25 2 7 18 9 0 0.462 1.000 1.000 336 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(7), ACTG1(1), ACTN1(1), ACTN2(1), ACTN4(1), AKT1(1), AKT2(3), AKT3(1), ARHGAP5(3), BAD(1), BCAR1(2), BIRC3(1), BRAF(2), CAPN2(5), CAV1(1), CAV2(1), CAV3(1), CDC42(1), CHAD(1), COL11A1(4), COL11A2(7), COL1A1(9), COL1A2(3), COL2A1(5), COL3A1(5), COL4A1(4), COL4A2(4), COL4A4(10), COL4A6(6), COL5A1(7), COL5A2(5), COL5A3(7), COL6A1(4), COL6A2(3), COL6A3(10), COL6A6(7), CRKL(1), DIAPH1(5), DOCK1(5), EGF(2), EGFR(2), ERBB2(3), FARP2(3), FLNA(9), FLNB(7), FLNC(9), FLT1(2), FN1(7), GSK3B(2), HGF(1), HRAS(1), IBSP(1), IGF1R(4), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(2), ITGA2B(1), ITGA3(3), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGA9(2), ITGAV(2), ITGB1(5), ITGB3(3), ITGB4(5), ITGB5(6), ITGB7(2), ITGB8(1), KDR(4), LAMA1(5), LAMA2(8), LAMA3(10), LAMA4(4), LAMA5(9), LAMB1(7), LAMB2(4), LAMB3(6), LAMB4(1), LAMC1(2), LAMC2(1), LAMC3(2), MAPK10(2), MAPK9(2), MET(16), MYL7(1), MYL9(1), PAK1(1), PAK3(1), PAK4(2), PAK6(3), PAK7(1), PARVA(2), PARVG(1), PDGFA(1), PDGFD(1), PDGFRA(1), PDGFRB(3), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), PIP5K1C(3), PPP1CA(2), PPP1CC(1), PPP1R12A(1), PRKCG(5), PTEN(5), PTK2(1), PXN(1), RAC1(1), RAC2(1), RAF1(2), RAPGEF1(3), RELN(6), RHOA(2), ROCK2(4), SHC1(1), SHC2(5), SHC4(2), SOS1(3), SOS2(3), SRC(2), THBS1(5), THBS2(5), THBS3(5), TLN1(10), TLN2(5), TNC(5), TNN(1), TNR(2), TNXB(13), VAV1(1), VAV2(1), VAV3(5), VEGFA(1), VTN(1), VWF(7), ZYX(1) 94579655 488 130 478 176 208 41 74 78 85 2 0.972 1.000 1.000 337 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ACTN1(1), ACTN2(1), ACTN4(1), APC(1), APC2(2), ARAF(1), ARHGEF1(2), ARHGEF12(6), ARHGEF4(4), ARHGEF6(5), ARPC2(1), BAIAP2(3), BCAR1(2), BDKRB1(1), BDKRB2(1), BRAF(2), CD14(1), CDC42(1), CFL2(1), CHRM1(2), CHRM2(3), CHRM3(2), CRKL(1), CSK(1), CYFIP1(3), CYFIP2(2), DIAPH1(5), DIAPH2(2), DIAPH3(3), DOCK1(5), EGF(2), EGFR(2), EZR(1), F2(1), F2R(1), FGD1(1), FGD3(2), FGF1(3), FGF10(1), FGF12(1), FGF14(2), FGF16(1), FGF19(1), FGF21(3), FGF23(1), FGF3(3), FGF6(1), FGF8(1), FGFR1(5), FGFR2(3), FGFR3(6), FGFR4(3), FN1(7), GIT1(3), GNA12(1), GNA13(2), GNG12(1), GSN(2), HRAS(1), INS(3), IQGAP1(2), IQGAP2(6), IQGAP3(6), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(2), ITGA2B(1), ITGA3(3), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGA9(2), ITGAD(4), ITGAE(2), ITGAL(3), ITGAM(4), ITGAV(2), ITGAX(5), ITGB1(5), ITGB2(3), ITGB3(3), ITGB4(5), ITGB5(6), ITGB7(2), ITGB8(1), KRAS(2), LIMK1(6), LIMK2(7), MAP2K2(1), MSN(3), MYH10(2), MYH14(7), MYH9(5), MYL7(1), MYL9(1), NCKAP1(2), NCKAP1L(2), NRAS(1), PAK1(1), PAK3(1), PAK4(2), PAK6(3), PAK7(1), PDGFA(1), PDGFRA(1), PDGFRB(3), PFN1(1), PFN3(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), PIP4K2A(2), PIP5K1A(1), PIP5K1B(1), PIP5K1C(3), PPP1CA(2), PPP1CC(1), PPP1R12A(1), PPP1R12B(1), PTK2(1), PXN(1), RAC1(1), RAC2(1), RAF1(2), RDX(2), RHOA(2), ROCK2(4), RRAS(1), SCIN(6), SOS1(3), SOS2(3), SSH1(3), SSH2(6), SSH3(1), TIAM1(3), TIAM2(3), VAV1(1), VAV2(1), VAV3(5), WAS(2), WASF1(1), WASF2(1) 70664903 352 118 347 125 146 41 64 50 51 0 0.802 1.000 1.000 338 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 AKT1(1), AKT2(3), AKT3(1), ARRB1(5), ARRB2(2), ATF2(1), BDNF(3), BRAF(2), CACNA1A(10), CACNA1B(7), CACNA1C(9), CACNA1D(6), CACNA1E(3), CACNA1F(2), CACNA1G(5), CACNA1H(5), CACNA1I(7), CACNA1S(6), CACNA2D1(4), CACNA2D2(2), CACNA2D3(2), CACNA2D4(2), CACNB1(2), CACNB3(1), CACNB4(1), CACNG2(2), CACNG4(3), CACNG8(1), CD14(1), CDC42(1), CHUK(3), CRKL(1), DAXX(2), DUSP16(1), DUSP4(3), DUSP6(3), ECSIT(1), EGF(2), EGFR(2), ELK4(1), FASLG(2), FGF1(3), FGF10(1), FGF12(1), FGF14(2), FGF16(1), FGF19(1), FGF21(3), FGF23(1), FGF3(3), FGF6(1), FGF8(1), FGFR1(5), FGFR2(3), FGFR3(6), FGFR4(3), FLNA(9), FLNB(7), FLNC(9), FOS(1), GADD45B(1), GADD45G(1), GNA12(1), GNG12(1), HRAS(1), IKBKB(3), IL1B(1), IL1R1(1), IL1R2(3), KRAS(2), MAP2K2(1), MAP2K3(2), MAP2K5(3), MAP2K7(2), MAP3K1(7), MAP3K10(1), MAP3K12(1), MAP3K14(2), MAP3K2(1), MAP3K4(1), MAP3K5(1), MAP3K6(5), MAP3K7(1), MAP3K8(1), MAP4K1(3), MAP4K2(1), MAP4K3(5), MAP4K4(7), MAPK10(2), MAPK12(2), MAPK7(3), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(4), MAPK9(2), MAPKAPK3(1), MAX(1), NF1(2), NFATC2(3), NFATC4(4), NFKB1(3), NFKB2(3), NLK(2), NRAS(1), NTF3(1), NTRK1(5), NTRK2(2), PAK1(1), PDGFA(1), PDGFRA(1), PDGFRB(3), PLA2G12A(2), PLA2G2D(3), PLA2G3(1), PLA2G4A(3), PLA2G6(3), PPM1A(3), PPP3CA(3), PPP3CB(1), PPP5C(2), PRKACA(2), PRKACB(1), PRKACG(1), PRKCG(5), PRKX(3), PTPN5(1), PTPN7(1), PTPRR(3), RAC1(1), RAC2(1), RAF1(2), RAPGEF2(4), RASA1(2), RASA2(2), RASGRF1(7), RASGRF2(2), RASGRP1(2), RASGRP2(2), RASGRP3(1), RASGRP4(2), RPS6KA1(2), RPS6KA2(3), RPS6KA3(2), RPS6KA4(1), RPS6KA6(3), RRAS(1), SOS1(3), SOS2(3), SRF(1), STK4(1), TAOK1(2), TAOK2(1), TAOK3(2), TGFB1(2), TGFBR1(1), TGFBR2(1), TNF(1), TP53(7), TRAF2(1), ZAK(2) 73490293 399 111 395 131 188 40 57 53 59 2 0.391 1.000 1.000 339 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(1), ADCY2(6), ADCY3(3), ADCY4(5), ADCY8(4), ADCY9(7), ADORA2A(3), ADRA1A(3), ADRA1B(1), ATP2A1(3), ATP2A2(1), ATP2A3(2), ATP2B1(2), ATP2B2(1), ATP2B3(6), ATP2B4(3), AVPR1B(1), BDKRB1(1), BDKRB2(1), BST1(2), CACNA1A(10), CACNA1B(7), CACNA1C(9), CACNA1D(6), CACNA1E(3), CACNA1F(2), CACNA1G(5), CACNA1H(5), CACNA1I(7), CACNA1S(6), CAMK2A(4), CAMK2B(1), CAMK4(1), CCKAR(2), CCKBR(2), CD38(1), CHRM1(2), CHRM2(3), CHRM3(2), EDNRB(3), EGFR(2), ERBB2(3), ERBB3(3), ERBB4(5), F2R(1), GNA11(1), GNA14(1), GNAS(3), GRIN2A(2), GRIN2C(1), GRIN2D(3), GRM5(1), GRPR(1), HRH2(1), HTR2A(1), HTR2B(1), HTR4(1), HTR6(1), HTR7(1), ITPKA(3), ITPKB(3), ITPR1(9), ITPR2(6), ITPR3(4), NOS1(4), NOS3(3), NTSR1(1), P2RX1(2), P2RX2(1), P2RX3(1), P2RX5(1), P2RX7(1), PDE1C(1), PDGFRA(1), PDGFRB(3), PHKA1(9), PHKA2(3), PHKB(3), PHKG1(1), PHKG2(1), PLCB1(2), PLCB2(4), PLCB3(3), PLCB4(2), PLCD1(5), PLCD3(1), PLCE1(2), PLCG1(1), PLCG2(4), PLCZ1(1), PPP3CA(3), PPP3CB(1), PRKACA(2), PRKACB(1), PRKACG(1), PRKCG(5), PRKX(3), PTGFR(2), PTK2B(1), RYR1(12), RYR2(14), RYR3(16), SLC25A5(1), SLC8A1(5), SLC8A2(1), SLC8A3(3), SPHK1(2), TACR2(2), TBXA2R(1), TNNC1(1), VDAC1(1), VDAC2(1), VDAC3(1) 69127956 336 111 331 134 165 26 67 35 43 0 0.777 1.000 1.000 340 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(1), ADCY2(6), ADCY3(3), ADCY4(5), ADCY5(6), ADCY6(2), ADCY8(4), ADCY9(7), ADRA1A(3), ADRA1B(1), ANXA6(2), ARRB1(5), ARRB2(2), ATP1A4(1), ATP1B1(5), ATP2A2(1), ATP2A3(2), ATP2B1(2), ATP2B2(1), ATP2B3(6), CACNA1A(10), CACNA1B(7), CACNA1C(9), CACNA1D(6), CACNA1E(3), CACNA1S(6), CACNB1(2), CACNB3(1), CALR(1), CAMK1(2), CAMK2A(4), CAMK2B(1), CAMK4(1), CASQ1(2), CHRM1(2), CHRM2(3), CHRM3(2), GJB4(2), GJB5(2), GNA11(1), GNAI2(1), GNAI3(1), GNAZ(2), GNB1(2), GNG12(1), GRK4(1), GRK5(6), ITPR1(9), ITPR2(6), ITPR3(4), KCNB1(2), KCNJ3(2), MIB1(1), NME7(1), PKIB(2), PLCB3(3), PRKACA(2), PRKACB(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCD(3), PRKCE(2), PRKCG(5), PRKCQ(2), PRKD1(3), RGS1(1), RGS10(1), RGS11(1), RGS14(2), RGS16(1), RGS19(2), RGS2(1), RGS20(3), RGS3(2), RGS6(2), RGS7(1), RGS9(5), RYR1(12), RYR2(14), RYR3(16), SFN(1), SLC8A1(5), SLC8A3(3), USP5(2) 48014640 272 110 268 108 129 22 51 28 42 0 0.803 1.000 1.000 341 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 251 ACVR1(3), ACVR2A(3), ACVR2B(2), AMH(2), AMHR2(3), BMP7(1), BMPR1A(1), BMPR1B(1), CCL15(1), CCL17(1), CCL27(1), CCL28(1), CCL4(1), CCR1(1), CCR2(1), CCR3(2), CCR5(1), CCR7(2), CCR9(1), CD27(3), CD40(1), CLCF1(2), CNTF(1), CNTFR(2), CRLF2(1), CSF1(1), CSF1R(2), CSF2RA(2), CSF2RB(2), CSF3R(1), CX3CL1(2), CXCL1(1), CXCL11(1), CXCL13(1), CXCL14(1), CXCL16(1), EDA(2), EDA2R(1), EGF(2), EGFR(2), EPOR(3), FASLG(2), FLT1(2), FLT4(5), GDF5(2), GH2(1), HGF(1), IFNA16(1), IFNA2(1), IFNAR1(2), IFNGR1(1), IL10(1), IL10RA(5), IL12RB1(3), IL12RB2(1), IL15RA(1), IL17RA(3), IL17RB(4), IL19(1), IL1B(1), IL1R1(1), IL1R2(3), IL21R(3), IL22RA1(4), IL26(1), IL2RA(1), IL2RB(3), IL2RG(1), IL4R(1), IL5RA(2), IL6ST(3), IL7R(1), IL9(1), IL9R(5), INHBA(1), INHBB(1), KDR(4), KIT(1), LEP(2), LEPR(2), LIF(2), LIFR(4), LTA(1), LTBR(1), MET(16), MPL(2), OSM(1), OSMR(1), PDGFRA(1), PDGFRB(3), PLEKHO2(1), PRLR(1), TGFB1(2), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF10A(1), TNFRSF10D(1), TNFRSF13B(1), TNFRSF18(1), TNFRSF19(3), TNFRSF1B(1), TNFRSF21(3), TNFRSF25(1), TNFRSF6B(1), TNFSF10(3), TNFSF15(1), TNFSF8(2), TPO(1), VEGFA(1), XCL1(1), XCR1(1) 44962357 205 101 203 56 78 21 34 39 33 0 0.193 1.000 1.000 342 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(6), ABLIM1(3), ABLIM2(2), ABLIM3(4), ARHGEF12(6), CDC42(1), CDK5(1), CFL2(1), DCC(2), DPYSL2(1), EFNA1(2), EFNA2(1), EFNA3(2), EFNB2(1), EFNB3(1), EPHA1(2), EPHA2(2), EPHA3(2), EPHA4(1), EPHA5(1), EPHA6(3), EPHA7(2), EPHA8(4), EPHB1(5), EPHB4(2), EPHB6(2), FES(1), GNAI2(1), GNAI3(1), GSK3B(2), HRAS(1), ITGB1(5), KRAS(2), L1CAM(1), LIMK1(6), LIMK2(7), LRRC4C(4), MET(16), NCK2(2), NFAT5(3), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), NRAS(1), NRP1(1), NTN1(2), NTNG1(2), PAK1(1), PAK3(1), PAK4(2), PAK6(3), PAK7(1), PLXNA1(2), PLXNA2(11), PLXNA3(4), PLXNB1(8), PLXNB2(8), PLXNB3(4), PPP3CA(3), PPP3CB(1), PTK2(1), RAC1(1), RAC2(1), RASA1(2), RGS3(2), RHOA(2), ROBO1(7), ROBO2(3), ROBO3(3), ROCK2(4), SEMA3A(3), SEMA3C(2), SEMA3D(2), SEMA3E(3), SEMA3F(3), SEMA3G(1), SEMA4A(1), SEMA4B(2), SEMA4C(1), SEMA4D(4), SEMA4F(3), SEMA4G(2), SEMA5A(3), SEMA5B(5), SEMA6A(1), SEMA6B(4), SEMA6C(1), SEMA6D(2), SEMA7A(2), SLIT1(6), SLIT2(2), SLIT3(5), SRGAP1(5), SRGAP2(1), SRGAP3(1), UNC5A(3), UNC5B(3), UNC5C(1) 50134723 276 99 272 78 117 26 44 49 40 0 0.0965 1.000 1.000 343 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(1), CD36(1), CHAD(1), COL11A1(4), COL11A2(7), COL1A1(9), COL1A2(3), COL2A1(5), COL3A1(5), COL4A1(4), COL4A2(4), COL4A4(10), COL4A6(6), COL5A1(7), COL5A2(5), COL5A3(7), COL6A1(4), COL6A2(3), COL6A3(10), COL6A6(7), DAG1(6), FN1(7), FNDC1(4), FNDC3A(2), GP6(2), GP9(1), HSPG2(10), IBSP(1), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(2), ITGA2B(1), ITGA3(3), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGA9(2), ITGAV(2), ITGB1(5), ITGB3(3), ITGB4(5), ITGB5(6), ITGB7(2), ITGB8(1), LAMA1(5), LAMA2(8), LAMA3(10), LAMA4(4), LAMA5(9), LAMB1(7), LAMB2(4), LAMB3(6), LAMB4(1), LAMC1(2), LAMC2(1), LAMC3(2), RELN(6), SDC2(1), SDC3(1), SDC4(1), SV2A(1), SV2B(2), SV2C(1), THBS1(5), THBS2(5), THBS3(5), TNC(5), TNN(1), TNR(2), TNXB(13), VTN(1), VWF(7) 57320200 303 99 300 123 141 29 45 34 52 2 0.997 1.000 1.000 344 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(5), ACACB(5), AKT1(1), AKT2(3), AKT3(1), ARAF(1), BAD(1), BRAF(2), CBL(2), CBLB(3), CBLC(1), CRKL(1), EIF4EBP1(1), EXOC7(2), FASN(9), FLOT1(1), FOXO1(3), G6PC2(1), GCK(2), GSK3B(2), GYS1(2), GYS2(2), HRAS(1), IKBKB(3), INPP5D(1), INS(3), INSR(3), IRS1(1), IRS2(2), KRAS(2), LIPE(2), MAP2K2(1), MAPK10(2), MAPK9(2), NRAS(1), PCK1(1), PCK2(1), PDE3B(3), PFKL(4), PFKP(3), PHKA1(9), PHKA2(3), PHKB(3), PHKG1(1), PHKG2(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), PKLR(1), PPARGC1A(4), PPP1CA(2), PPP1CC(1), PPP1R3A(2), PRKAB1(1), PRKACA(2), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAG2(3), PRKAG3(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCI(4), PRKX(3), PTPN1(2), PTPRF(5), PYGB(2), PYGL(2), PYGM(4), RAF1(2), RAPGEF1(3), RHEB(2), SH2B2(3), SHC1(1), SHC2(5), SHC4(2), SLC2A4(1), SORBS1(3), SOS1(3), SOS2(3), SREBF1(3), TRIP10(2), TSC1(3), TSC2(6) 40940348 205 97 202 77 80 14 48 35 28 0 0.800 1.000 1.000 345 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(1), ACTA2(1), ADCY1(1), ADCY2(6), ADCY3(3), ADCY4(5), ADCY5(6), ADCY6(2), ADCY8(4), ADCY9(7), ADM(1), ARRB1(5), ARRB2(2), ATF2(1), ATF3(1), ATF5(1), ATP2A2(1), ATP2A3(2), CACNB3(1), CAMK2A(4), CAMK2B(1), CORIN(1), CREB3(3), DGKZ(8), FOS(1), GABPA(1), GABPB2(1), GBA2(1), GNB1(2), GNG12(1), GRK4(1), GRK5(6), IGFBP1(1), IGFBP3(1), IGFBP4(2), IGFBP6(2), IL1B(1), ITPR1(9), ITPR2(6), ITPR3(4), MIB1(1), NFKB1(3), NOS1(4), NOS3(3), PDE4B(1), PDE4D(1), PKIB(2), PLCB3(3), PLCD1(5), PLCG1(1), PLCG2(4), PRKACA(2), PRKACB(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCD(3), PRKCE(2), PRKCQ(2), PRKD1(3), RGS1(1), RGS10(1), RGS11(1), RGS14(2), RGS16(1), RGS19(2), RGS2(1), RGS20(3), RGS3(2), RGS6(2), RGS7(1), RGS9(5), RYR1(12), RYR2(14), RYR3(16), SFN(1), SLC8A1(5), TNXB(13), USP5(2) 44237865 237 97 235 89 113 20 44 22 38 0 0.701 1.000 1.000 346 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 137 ACTB(7), ACTG1(1), CHAD(1), COL11A1(4), COL11A2(7), COL17A1(2), COL1A1(9), COL1A2(3), COL2A1(5), COL3A1(5), COL4A1(4), COL4A2(4), COL4A4(10), COL4A6(6), COL5A1(7), COL5A2(5), COL5A3(7), COL6A1(4), COL6A2(3), COL6A3(10), COL6A6(7), DES(2), DSC2(3), DSC3(5), DSG2(1), DSG3(1), DSG4(3), FN1(7), GJA3(1), GJB4(2), GJB5(2), GJC1(2), GJC3(1), IBSP(1), ITGA6(3), ITGB4(5), KRT1(1), KRT10(1), KRT13(4), KRT16(1), KRT17(2), KRT18(1), KRT2(3), KRT20(1), KRT23(1), KRT27(2), KRT3(2), KRT32(1), KRT33A(1), KRT35(2), KRT36(2), KRT37(3), KRT38(1), KRT4(2), KRT40(1), KRT6A(1), KRT6B(2), KRT6C(1), KRT71(1), KRT74(1), KRT75(1), KRT76(1), KRT77(4), KRT78(4), KRT79(1), KRT82(1), KRT83(1), KRT84(1), KRT85(3), KRT86(2), KRT9(3), LAMA1(5), LAMA2(8), LAMA3(10), LAMA4(4), LAMA5(9), LAMB1(7), LAMB2(4), LAMB3(6), LAMB4(1), LAMC1(2), LAMC2(1), LAMC3(2), LMNA(3), LMNB2(1), NES(1), PRPH(2), RELN(6), THBS1(5), THBS2(5), THBS3(5), TNC(5), TNN(1), TNR(2), TNXB(13), VIM(1), VTN(1), VWF(7) 63479180 327 96 323 127 145 27 54 46 53 2 0.983 1.000 1.000 347 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 237 ADORA1(2), ADORA2A(3), ADORA3(2), ADRA1A(3), ADRA1B(1), ADRA2B(2), ADRA2C(1), AGTR2(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(1), C3AR1(2), C5AR1(1), CALCR(1), CALCRL(1), CCKAR(2), CCKBR(2), CHRM1(2), CHRM2(3), CHRM3(2), CNR1(1), CNR2(1), DRD4(2), DRD5(3), EDNRB(3), F2(1), F2R(1), F2RL2(1), F2RL3(1), GABBR1(2), GABBR2(3), GABRA3(2), GABRA4(1), GABRB2(1), GABRB3(3), GABRD(1), GABRE(1), GABRG1(1), GABRG2(1), GABRG3(3), GABRP(2), GABRQ(2), GH2(1), GHRHR(1), GHSR(1), GIPR(1), GLP1R(2), GLP2R(2), GLRA2(1), GLRA3(1), GLRB(2), GNRHR(1), GPR156(1), GPR50(1), GPR83(1), GRIA1(2), GRIA2(2), GRID1(3), GRID2(4), GRIK1(3), GRIK2(2), GRIK3(2), GRIK4(1), GRIK5(3), GRIN2A(2), GRIN2B(5), GRIN2C(1), GRIN2D(3), GRIN3A(2), GRIN3B(2), GRM2(5), GRM3(1), GRM4(6), GRM5(1), GRPR(1), HCRTR2(4), HRH2(1), HRH3(1), HTR1B(1), HTR2A(1), HTR2B(1), HTR4(1), HTR6(1), HTR7(1), LEP(2), LEPR(2), MC2R(1), MC4R(1), MCHR1(2), MLNR(1), NMUR2(3), NPBWR1(3), NPFFR1(1), NPFFR2(1), NPY1R(1), NPY2R(1), NR3C1(2), NTSR1(1), OPRD1(1), OPRL1(1), P2RX1(2), P2RX2(1), P2RX3(1), P2RX5(1), P2RX7(1), P2RY1(2), P2RY2(1), P2RY6(2), PARD3(2), PRLR(1), PRSS3(3), PTGDR(2), PTGFR(2), PTGIR(1), RXFP2(2), SSTR1(2), SSTR3(2), SSTR4(2), TAAR9(1), TACR2(2), TBXA2R(1), THRA(1), THRB(1), TRPV1(4), UTS2R(2), VIPR2(1) 56037872 218 96 217 86 93 22 52 39 12 0 0.527 1.000 1.000 348 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(1), APC2(2), AXIN1(5), AXIN2(1), BTRC(1), CACYBP(1), CAMK2A(4), CAMK2B(1), CHD8(12), CREBBP(5), CSNK1A1(1), CSNK1E(3), CSNK2A1(5), CSNK2B(2), CTBP1(3), CTBP2(5), CUL1(4), DAAM1(1), DAAM2(1), DVL2(1), DVL3(3), EP300(11), FBXW11(2), FOSL1(1), FZD1(2), FZD10(1), FZD4(2), FZD5(2), FZD7(1), GSK3B(2), LEF1(2), LRP5(8), LRP6(9), MAP3K7(1), MAPK10(2), MAPK9(2), NFAT5(3), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), NKD1(2), NKD2(4), NLK(2), PLCB1(2), PLCB2(4), PLCB3(3), PLCB4(2), PORCN(1), PPARD(1), PPP2CB(1), PPP2R1A(1), PPP2R2A(2), PPP2R2C(2), PPP3CA(3), PPP3CB(1), PRICKLE1(2), PRICKLE2(3), PRKACA(2), PRKACB(1), PRKACG(1), PRKCG(5), PRKX(3), PSEN1(2), RAC1(1), RAC2(1), RBX1(1), RHOA(2), ROCK2(4), RUVBL1(2), SFRP1(1), SFRP4(1), SFRP5(2), SKP1(1), SMAD2(2), SMAD4(2), TBL1X(3), TBL1XR1(3), TCF7(3), TCF7L1(2), TP53(7), VANGL1(3), VANGL2(1), WIF1(2), WNT10A(2), WNT10B(1), WNT16(1), WNT2(1), WNT2B(1), WNT3(2), WNT5B(1), WNT8A(1), WNT8B(2) 40945516 230 94 228 68 101 24 36 29 39 1 0.246 1.000 1.000 349 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(2), ADCY1(1), ADCY2(6), ADCY3(3), ADCY4(5), ADCY5(6), ADCY6(2), ADCY8(4), ADCY9(7), ADK(2), ADSL(2), ADSS(1), ADSSL1(2), AK2(1), AK5(1), AK7(2), ALLC(2), AMPD2(3), AMPD3(1), APRT(1), ATIC(1), DCK(1), DGUOK(1), ENPP1(6), ENPP3(1), ENTPD1(1), ENTPD5(4), ENTPD6(2), GART(3), GMPR(1), GMPS(1), GUCY1A2(1), GUCY1B3(2), GUCY2C(3), GUCY2D(4), GUCY2F(1), HPRT1(1), IMPDH1(1), IMPDH2(1), NME1(1), NME7(1), NPR2(3), NT5C1A(1), NT5C1B(1), NT5C2(1), NUDT5(2), PAPSS2(4), PDE10A(2), PDE11A(4), PDE1C(1), PDE2A(3), PDE3B(3), PDE4A(2), PDE4B(1), PDE4C(1), PDE4D(1), PDE5A(5), PDE6D(1), PDE7B(1), PDE8A(1), PDE8B(2), PDE9A(2), PFAS(4), PKLR(1), PNPT1(3), POLA1(5), POLA2(1), POLD1(4), POLD2(2), POLD4(1), POLR1A(1), POLR1B(2), POLR1C(1), POLR1D(1), POLR2A(4), POLR2B(4), POLR2F(1), POLR2I(1), POLR2J(1), POLR3A(3), POLR3B(3), POLR3GL(1), PPAT(2), PRIM1(1), PRIM2(3), PRPS1(1), PRPS2(3), PRUNE(2), RFC5(2), RRM1(3), XDH(2) 41508452 197 91 196 69 79 17 40 29 32 0 0.714 1.000 1.000 350 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(1), CADM1(2), CADM3(2), CD2(1), CD22(2), CD34(1), CD4(2), CD40(1), CD58(1), CD6(2), CD86(3), CDH15(3), CDH2(1), CDH3(1), CDH4(1), CDH5(2), CLDN11(1), CLDN16(1), CLDN18(1), CLDN19(1), CLDN2(1), CLDN5(1), CLDN7(1), CNTN1(5), CNTN2(3), CNTNAP1(3), CTLA4(2), ESAM(2), GLG1(1), HLA-A(1), HLA-B(2), HLA-C(1), HLA-DOA(1), HLA-DPB1(1), HLA-DQA2(1), ICAM1(1), ICOS(1), ITGA4(2), ITGA6(3), ITGA8(3), ITGA9(2), ITGAL(3), ITGAM(4), ITGAV(2), ITGB1(5), ITGB2(3), ITGB7(2), ITGB8(1), JAM2(2), L1CAM(1), MADCAM1(1), MPZL1(1), NCAM1(5), NCAM2(5), NEGR1(1), NEO1(6), NFASC(5), NLGN1(2), NLGN3(1), NRCAM(5), NRXN1(2), NRXN2(6), NRXN3(2), PDCD1(1), PDCD1LG2(3), PTPRC(2), PTPRF(5), PTPRM(7), PVRL1(3), PVRL2(1), PVRL3(2), SDC2(1), SDC3(1), SDC4(1), SELE(1), SELL(2), SELP(2), SELPLG(1), SIGLEC1(4), SPN(1), VCAM1(2), VCAN(12) 37421795 185 88 184 88 71 20 28 32 34 0 0.996 1.000 1.000 351 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(7), ACTG1(1), ACTN1(1), ACTN2(1), ACTN4(1), AKT1(1), AKT2(3), AKT3(1), AMOTL1(4), ASH1L(5), CASK(2), CDC42(1), CDK4(1), CGN(5), CLDN11(1), CLDN16(1), CLDN18(1), CLDN19(1), CLDN2(1), CLDN5(1), CLDN7(1), CRB3(1), CSDA(2), CSNK2A1(5), CSNK2B(2), CTNNA1(5), CTNNA2(2), CTNNA3(2), CTTN(2), EPB41(1), EPB41L1(5), EPB41L3(4), EXOC4(3), GNAI2(1), GNAI3(1), HRAS(1), INADL(7), JAM2(2), KRAS(2), LLGL1(1), LLGL2(2), MAGI1(3), MAGI2(3), MAGI3(2), MLLT4(5), MPDZ(2), MYH1(1), MYH10(2), MYH11(3), MYH13(4), MYH14(7), MYH15(3), MYH2(1), MYH3(1), MYH4(5), MYH6(8), MYH7(6), MYH7B(1), MYH8(1), MYH9(5), MYL7(1), MYL9(1), NRAS(1), PARD3(2), PARD6B(4), PPM1J(1), PPP2CB(1), PPP2R1A(1), PPP2R2A(2), PPP2R2C(2), PPP2R3A(1), PPP2R3B(1), PPP2R4(2), PRKCD(3), PRKCE(2), PRKCG(5), PRKCI(4), PRKCQ(2), PTEN(5), RAB13(1), RAB3B(2), RHOA(2), RRAS(1), SPTAN1(6), SRC(2), SYMPK(2), TJAP1(4), TJP1(5), TJP2(3), YES1(1), ZAK(2) 49106692 227 88 224 86 89 13 32 49 44 0 0.936 1.000 1.000 352 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(1), AKT3(1), BCAR1(2), CAPN1(4), CAPN10(2), CAPN11(2), CAPN2(5), CAPN3(1), CAPN5(3), CAPN7(4), CAPN9(1), CAV1(1), CAV2(1), CAV3(1), CDC42(1), CSK(1), DOCK1(5), GIT2(3), ITGA10(2), ITGA11(3), ITGA2(2), ITGA2B(1), ITGA3(3), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGA9(2), ITGAD(4), ITGAE(2), ITGAL(3), ITGAM(4), ITGAV(2), ITGAX(5), ITGB1(5), ITGB2(3), ITGB3(3), ITGB4(5), ITGB5(6), ITGB7(2), ITGB8(1), MAP2K2(1), MAP2K3(2), MAPK10(2), MAPK12(2), MAPK4(1), MAPK6(1), MAPK7(3), PAK1(1), PAK3(1), PAK4(2), PAK6(3), PIK3R2(3), PTK2(1), PXN(1), RAC1(1), RAC2(1), RAPGEF1(3), ROCK2(4), SDCCAG8(2), SEPP1(2), SHC1(1), SORBS1(3), SOS1(3), SRC(2), TLN1(10), TNS1(9), VAV2(1), VAV3(5), ZYX(1) 34321586 180 87 175 69 70 19 34 27 30 0 0.873 1.000 1.000 353 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 56 ASH1L(5), ASH2L(2), CARM1(1), CTCFL(3), DOT1L(6), EED(2), EHMT1(3), EHMT2(7), EZH1(1), FBXO11(4), HCFC1(4), JMJD4(2), KDM6A(11), MEN1(2), MLL(4), MLL2(21), MLL3(18), MLL4(13), MLL5(5), NSD1(8), OGT(2), PAXIP1(6), PPP1CA(2), PPP1CC(1), PRDM2(4), PRDM7(1), PRDM9(2), PRMT5(2), PRMT6(1), PRMT7(3), RBBP5(2), SATB1(2), SETD1A(4), SETD2(17), SETDB1(5), SETDB2(2), SUV39H1(2), SUV39H2(1), SUV420H1(1), SUV420H2(1), SUZ12(2), WHSC1(1), WHSC1L1(2) 30736150 188 86 186 38 65 18 32 24 47 2 0.0664 1.000 1.000 354 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(1), AKT2(3), AKT3(1), CBL(2), CBLB(3), CBLC(1), CISH(2), CLCF1(2), CNTF(1), CNTFR(2), CREBBP(5), CRLF2(1), CSF2RA(2), CSF2RB(2), CSF3R(1), EP300(11), EPOR(3), GH2(1), IFNA16(1), IFNA2(1), IFNAR1(2), IFNGR1(1), IL10(1), IL10RA(5), IL12RB1(3), IL12RB2(1), IL13RA2(1), IL15RA(1), IL19(1), IL21R(3), IL22RA1(4), IL26(1), IL2RA(1), IL2RB(3), IL2RG(1), IL4R(1), IL5RA(2), IL6ST(3), IL7R(1), IL9(1), IL9R(5), IRF9(2), JAK1(4), JAK2(3), JAK3(4), LEP(2), LEPR(2), LIF(2), LIFR(4), MPL(2), OSM(1), OSMR(1), PIAS1(2), PIAS2(1), PIAS3(4), PIAS4(3), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), PRLR(1), PTPN11(2), SOCS5(1), SOCS7(2), SOS1(3), SOS2(3), SPRED2(1), SPRY2(1), SPRY4(2), STAM(2), STAM2(1), STAT1(2), STAT3(1), STAT5A(3), STAT5B(2), STAT6(4), TPO(1), TYK2(2) 36782523 173 83 172 48 73 19 29 23 29 0 0.418 1.000 1.000 355 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(6), ANAPC10(1), ANAPC2(2), ANAPC4(1), ANAPC5(4), ATM(6), ATR(4), BUB1(1), CCNA1(1), CCNB1(1), CCNB2(1), CCNB3(2), CCNE1(2), CCNE2(1), CCNH(1), CDC14A(2), CDC14B(1), CDC16(1), CDC20(3), CDC25C(1), CDC27(7), CDC6(2), CDC7(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(2), CHEK1(2), CHEK2(2), CREBBP(5), CUL1(4), E2F2(2), E2F3(2), EP300(11), ESPL1(6), FZR1(4), GADD45B(1), GADD45G(1), GSK3B(2), MAD1L1(1), MAD2L2(1), MCM2(3), MCM3(2), MCM4(3), MCM5(2), MCM6(3), MCM7(2), MDM2(1), PKMYT1(1), PLK1(1), PRKDC(4), RBL1(2), RBL2(4), RBX1(1), SFN(1), SKP1(1), SKP2(1), SMAD2(2), SMAD4(2), SMC1A(6), SMC1B(3), TFDP1(1), TGFB1(2), TP53(7), WEE1(1), YWHAE(1) 34466225 158 82 157 46 69 16 27 24 22 0 0.433 1.000 1.000 356 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(3), AKT1(1), AURKB(1), BMPR1A(1), BUB1(1), CDIPT(1), CDKL2(3), CDS2(2), CLK1(2), CLK4(2), COL4A3BP(1), CSNK2A1(5), CSNK2B(2), DGKA(1), DGKB(1), DGKD(3), DGKE(1), DGKG(4), DGKH(5), DGKQ(2), DGKZ(8), INPP4A(3), INPP4B(4), INPPL1(3), ITPKA(3), ITPKB(3), MAP3K10(1), NEK1(1), NEK3(1), OCRL(5), PAK4(2), PIK3C2A(5), PIK3C2B(5), PIK3C2G(6), PIK3CA(2), PIK3CB(1), PIK3CG(2), PIM2(1), PLCB1(2), PLCB2(4), PLCB3(3), PLCB4(2), PLCD1(5), PLCG1(1), PLCG2(4), PLK3(1), PRKACA(2), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCD(3), PRKCE(2), PRKCG(5), PRKCQ(2), PRKD1(3), PRKG1(1), RAF1(2), RPS6KA1(2), RPS6KA2(3), RPS6KA3(2), RPS6KA4(1), STK11(3), TGFBR1(1), VRK1(2) 28798772 159 80 157 61 67 13 29 19 31 0 0.920 1.000 1.000 357 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACTB(7), ACTG1(1), ACTN1(1), ACTN2(1), ACTN4(1), BAIAP2(3), CDC42(1), CREBBP(5), CSNK2A1(5), CSNK2B(2), CTNNA1(5), CTNNA2(2), CTNNA3(2), CTNND1(4), EGFR(2), EP300(11), ERBB2(3), FARP2(3), FGFR1(5), IGF1R(4), INSR(3), IQGAP1(2), LEF1(2), LMO7(2), MAP3K7(1), MET(16), MLLT4(5), NLK(2), PARD3(2), PTPN1(2), PTPRB(3), PTPRF(5), PTPRJ(6), PTPRM(7), PVRL1(3), PVRL2(1), PVRL3(2), RAC1(1), RAC2(1), RHOA(2), SMAD2(2), SMAD4(2), SNAI2(2), SORBS1(3), SRC(2), SSX2IP(2), TCF7(3), TCF7L1(2), TGFBR1(1), TGFBR2(1), TJP1(5), WAS(2), WASF1(1), WASF2(1), YES1(1) 30356639 166 79 164 52 58 12 25 39 31 1 0.649 1.000 1.000 358 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(2), ADCY1(1), ADCY2(6), ADCY3(3), ADCY4(5), ADCY5(6), ADCY6(2), ADCY8(4), ADK(2), ADSL(2), ADSS(1), AK2(1), AK5(1), ALLC(2), AMPD2(3), AMPD3(1), APRT(1), ATIC(1), ATP1B1(5), ATP5A1(1), ATP5B(2), ATP5F1(1), ATP5G2(1), ATP5J2(1), DCK(1), DGUOK(1), ENPP1(6), ENPP3(1), ENTPD1(1), GART(3), GMPS(1), GUCY1A2(1), GUCY1B3(2), GUCY2C(3), GUCY2D(4), GUCY2F(1), HPRT1(1), IMPDH1(1), IMPDH2(1), NME1(1), NPR2(3), PAPSS2(4), PDE4A(2), PDE4B(1), PDE4C(1), PDE4D(1), PDE5A(5), PDE6B(2), PDE6C(1), PDE7B(1), PDE8A(1), PDE9A(2), PFAS(4), PKLR(1), POLB(2), POLD1(4), POLD2(2), POLG(6), POLQ(8), POLR1B(2), POLR2A(4), POLR2B(4), POLR2F(1), POLR2I(1), POLR2J(1), POLRMT(2), PPAT(2), PRPS1(1), PRPS2(3), PRUNE(2), RRM1(3) 32575425 161 79 160 54 57 13 29 30 32 0 0.702 1.000 1.000 359 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CDIPT(1), CDS2(2), DGKA(1), DGKB(1), DGKD(3), DGKE(1), DGKG(4), DGKH(5), DGKQ(2), DGKZ(8), FN3K(1), INPP4A(3), INPP4B(4), INPP5B(2), INPP5D(1), INPP5E(1), INPPL1(3), ITPK1(1), ITPKA(3), ITPKB(3), ITPR1(9), ITPR2(6), ITPR3(4), OCRL(5), PI4KA(5), PI4KB(1), PIK3C2A(5), PIK3C2B(5), PIK3C2G(6), PIK3C3(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), PIP4K2A(2), PIP5K1A(1), PIP5K1B(1), PIP5K1C(3), PLCB1(2), PLCB2(4), PLCB3(3), PLCB4(2), PLCD1(5), PLCD3(1), PLCE1(2), PLCG1(1), PLCG2(4), PLCZ1(1), PRKCG(5), PTEN(5), SYNJ1(4), SYNJ2(2) 31818401 159 76 157 56 71 15 23 22 28 0 0.749 1.000 1.000 360 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(6), ABCA10(2), ABCA12(10), ABCA13(15), ABCA2(2), ABCA3(4), ABCA4(10), ABCA5(4), ABCA6(4), ABCA7(8), ABCA8(5), ABCA9(1), ABCB1(2), ABCB10(2), ABCB11(5), ABCB4(4), ABCB5(1), ABCB6(3), ABCB7(1), ABCB8(1), ABCB9(5), ABCC1(4), ABCC10(9), ABCC11(6), ABCC12(3), ABCC2(4), ABCC3(3), ABCC4(4), ABCC5(6), ABCC6(4), ABCC9(4), ABCD2(3), ABCD3(1), ABCD4(2), ABCG1(1), ABCG2(2), ABCG4(2), ABCG5(3), ABCG8(1), CFTR(3), TAP1(3) 30073707 163 73 162 51 86 17 29 19 12 0 0.229 1.000 1.000 361 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(1), ADCY2(6), ADCY3(3), ADCY4(5), ADCY5(6), ADCY6(2), ADCY8(4), ADCY9(7), CACNA1C(9), CACNA1D(6), CACNA1F(2), CACNA1S(6), CAMK2A(4), CAMK2B(1), CDC42(1), EGFR(2), GNA11(1), GNAS(3), GNRHR(1), HBEGF(1), HRAS(1), ITPR1(9), ITPR2(6), ITPR3(4), KRAS(2), MAP2K2(1), MAP2K3(2), MAP2K7(2), MAP3K1(7), MAP3K2(1), MAP3K4(1), MAPK10(2), MAPK12(2), MAPK7(3), MAPK9(2), MMP14(1), NRAS(1), PLA2G12A(2), PLA2G2D(3), PLA2G3(1), PLA2G4A(3), PLA2G6(3), PLCB1(2), PLCB2(4), PLCB3(3), PLCB4(2), PLD1(2), PLD2(1), PRKACA(2), PRKACB(1), PRKACG(1), PRKCD(3), PRKX(3), PTK2B(1), RAF1(2), SOS1(3), SOS2(3), SRC(2) 32587332 165 73 161 63 75 17 33 13 27 0 0.738 1.000 1.000 362 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(1), ADCY2(6), ADCY3(3), ADCY4(5), ADCY5(6), ADCY6(2), ADCY8(4), ADCY9(7), ASIP(2), CAMK2A(4), CAMK2B(1), CREB3(3), CREB3L2(1), CREB3L3(1), CREB3L4(1), CREBBP(5), DCT(2), DVL2(1), DVL3(3), EDNRB(3), EP300(11), FZD1(2), FZD10(1), FZD4(2), FZD5(2), FZD7(1), GNAI2(1), GNAI3(1), GNAS(3), GSK3B(2), HRAS(1), KIT(1), KRAS(2), LEF1(2), MAP2K2(1), MITF(3), NRAS(1), PLCB1(2), PLCB2(4), PLCB3(3), PLCB4(2), POMC(1), PRKACA(2), PRKACB(1), PRKACG(1), PRKCG(5), PRKX(3), RAF1(2), TCF7(3), TCF7L1(2), TYRP1(3), WNT10A(2), WNT10B(1), WNT16(1), WNT2(1), WNT2B(1), WNT3(2), WNT5B(1), WNT8A(1), WNT8B(2) 27703552 144 73 141 52 60 14 29 18 23 0 0.634 1.000 1.000 363 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(4), AMY2B(1), ASCC3(1), ATP13A2(4), DDX23(2), DDX4(3), DDX41(3), DDX47(3), DDX50(3), DDX51(2), DDX52(1), DDX54(2), DDX55(1), DDX56(3), DHX58(3), ENPP1(6), ENPP3(1), ENTPD7(6), EP400(6), ERCC2(5), ERCC3(3), G6PC2(1), GAA(2), GANC(2), GBA(1), GBA3(1), GBE1(3), GCK(2), GYS1(2), GYS2(2), HK1(1), HK2(2), IFIH1(3), MGAM(6), MOV10L1(2), NUDT5(2), PGM1(2), PGM3(1), PYGB(2), PYGL(2), PYGM(4), RAD54B(3), RUVBL2(2), SETX(2), SI(4), SKIV2L2(2), SMARCA2(2), SMARCA5(3), TREH(2), UGDH(1), UGT1A1(1), UGT1A3(1), UGT1A5(2), UGT1A9(2), UGT2A1(4), UGT2A3(1), UGT2B10(1), UGT2B17(1), UGT2B28(1), UGT2B7(2) 31296198 143 72 143 52 63 12 19 33 16 0 0.846 1.000 1.000 364 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(1), ADCY2(6), ADCY3(3), ADCY4(5), ADCY5(6), ADCY6(2), ADCY8(4), ADCY9(7), CSNK1D(1), EGF(2), EGFR(2), GNA11(1), GNAI2(1), GNAI3(1), GNAS(3), GRM5(1), GUCY1A2(1), GUCY1B3(2), GUCY2C(3), GUCY2D(4), GUCY2F(1), HRAS(1), HTR2A(1), HTR2B(1), ITPR1(9), ITPR2(6), ITPR3(4), KRAS(2), MAP2K2(1), MAP2K5(3), MAP3K2(1), MAPK7(3), NPR2(3), NRAS(1), PDGFA(1), PDGFD(1), PDGFRA(1), PDGFRB(3), PLCB1(2), PLCB2(4), PLCB3(3), PLCB4(2), PRKACA(2), PRKACB(1), PRKACG(1), PRKCG(5), PRKG1(1), PRKG2(3), PRKX(3), RAF1(2), SOS1(3), SOS2(3), SRC(2), TJP1(5), TUBA4A(2), TUBB(2), TUBB1(1), TUBB2A(1), TUBB8(1) 33558724 148 72 145 57 60 17 32 17 22 0 0.770 1.000 1.000 365 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(1), BRAF(2), CACNA1A(10), GNA11(1), GNA12(1), GNA13(2), GNAI2(1), GNAI3(1), GNAS(3), GNAZ(2), GRIA1(2), GRIA2(2), GRID2(4), GRM5(1), GUCY1A2(1), GUCY1B3(2), GUCY2C(3), GUCY2D(4), GUCY2F(1), HRAS(1), IGF1R(4), ITPR1(9), ITPR2(6), ITPR3(4), KRAS(2), LYN(1), MAP2K2(1), NOS1(4), NOS3(3), NPR2(3), NRAS(1), PLA2G12A(2), PLA2G2D(3), PLA2G3(1), PLA2G4A(3), PLA2G6(3), PLCB1(2), PLCB2(4), PLCB3(3), PLCB4(2), PPP2CB(1), PPP2R1A(1), PPP2R2A(2), PPP2R2C(2), PRKCG(5), PRKG1(1), PRKG2(3), RAF1(2), RYR1(12) 28091372 135 72 134 39 51 15 27 24 18 0 0.234 1.000 1.000 366 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CDC40(1), CLK3(2), CLK4(2), COL2A1(5), CPSF1(4), CPSF2(2), CPSF3(3), CSTF2T(1), DDX1(1), DDX20(4), DHX16(3), DHX38(5), DHX8(1), DHX9(4), DICER1(3), FUS(3), GIPC1(1), LOC440563(1), METTL3(2), NONO(4), NXF1(2), PAPOLA(1), POLR2A(4), PRPF18(2), PRPF3(1), PRPF4(2), PRPF4B(4), PRPF8(6), PTBP1(1), RBM17(3), RBM5(1), RNMT(2), RNPS1(1), SF3A1(1), SF3A3(1), SF3B1(9), SF3B2(6), SF3B4(5), SNRPA(2), SNRPB(2), SNRPB2(1), SNRPE(1), SPOP(1), SRPK1(2), SRPK2(2), SRRM1(6), SUPT5H(4), U2AF2(2), XRN2(1) 26797666 128 70 124 33 52 9 26 19 22 0 0.354 1.000 1.000 367 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(1), ACTA2(1), ACTN2(1), ACTN4(1), DES(2), DMD(8), MYBPC1(3), MYBPC2(4), MYBPC3(2), MYH3(1), MYH6(8), MYH7(6), MYH8(1), MYL1(1), MYL9(1), MYOM1(6), NEB(20), TCAP(1), TMOD1(2), TNNI3(1), TNNT1(2), TPM1(2), TPM4(1), TTN(63), VIM(1) 34644073 140 70 137 42 56 10 26 20 28 0 0.470 1.000 1.000 368 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(1), BID(2), BRAF(2), CD244(1), CD48(1), FASLG(2), FCER1G(1), FCGR3A(2), HCST(1), HLA-A(1), HLA-B(2), HLA-C(1), HRAS(1), ICAM1(1), IFNA16(1), IFNA2(1), IFNAR1(2), IFNGR1(1), ITGAL(3), ITGB2(3), KIR2DL4(1), KIR3DL2(1), KLRC1(1), KLRC2(1), KLRC3(1), KRAS(2), LAT(2), LCP2(3), MAP2K2(1), MICA(1), MICB(1), NCR2(3), NFAT5(3), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), NRAS(1), PAK1(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), PLCG1(1), PLCG2(4), PPP3CA(3), PPP3CB(1), PRF1(2), PRKCG(5), PTK2B(1), PTPN11(2), RAC1(1), RAC2(1), RAF1(2), SH2D1B(1), SH3BP2(4), SHC1(1), SHC2(5), SHC4(2), SOS1(3), SOS2(3), SYK(2), TNF(1), TNFRSF10A(1), TNFRSF10D(1), TNFSF10(3), TYROBP(2), ULBP1(3), VAV1(1), VAV2(1), VAV3(5), ZAP70(2) 28702061 142 69 139 43 53 11 21 27 30 0 0.637 1.000 1.000 369 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 163 ADORA1(2), ADORA2A(3), ADORA3(2), ADRA1A(3), ADRA1B(1), ADRA2C(1), AGTR2(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(1), C3AR1(2), CCBP2(2), CCKAR(2), CCKBR(2), CCR1(1), CCR2(1), CCR3(2), CCR5(1), CCR7(2), CCR9(1), CCRL1(1), CCRL2(3), CHML(1), CHRM1(2), CHRM2(3), CHRM3(2), CNR1(1), CNR2(1), DRD4(2), DRD5(3), EDNRB(3), F2R(1), F2RL2(1), F2RL3(1), GHSR(1), GPR174(2), GPR3(1), GPR37(2), GPR37L1(2), GPR4(1), GPR50(1), GPR83(1), GPR85(1), GPR87(1), GRPR(1), HCRTR2(4), HRH2(1), HRH3(1), HTR1B(1), HTR2A(1), HTR2B(1), HTR4(1), HTR6(1), HTR7(1), MC4R(1), MLNR(1), NMUR2(3), NPY1R(1), NPY2R(1), NTSR1(1), OPRD1(1), OPRL1(1), OR10A5(1), OR11A1(1), OR12D3(1), OR1F1(1), OR5V1(1), P2RY1(2), P2RY2(1), P2RY6(2), PTGDR(2), PTGFR(2), PTGIR(1), RGR(1), SSTR1(2), SSTR3(2), SSTR4(2), SUCNR1(1), TBXA2R(1) 30597762 118 67 118 43 45 13 26 22 12 0 0.348 1.000 1.000 370 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(6), ABL2(2), AKT1(1), AKT2(3), AKT3(1), ARAF(1), BAD(1), BRAF(2), BTC(1), CAMK2A(4), CAMK2B(1), CBL(2), CBLB(3), CBLC(1), CDKN1A(1), CRKL(1), EGF(2), EGFR(2), EIF4EBP1(1), ERBB2(3), ERBB3(3), ERBB4(5), EREG(1), GAB1(2), GSK3B(2), HBEGF(1), HRAS(1), KRAS(2), MAP2K2(1), MAP2K7(2), MAPK10(2), MAPK9(2), NCK2(2), NRAS(1), NRG1(4), NRG2(1), NRG3(4), PAK1(1), PAK3(1), PAK4(2), PAK6(3), PAK7(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), PLCG1(1), PLCG2(4), PRKCG(5), PTK2(1), RAF1(2), SHC1(1), SHC2(5), SHC4(2), SOS1(3), SOS2(3), SRC(2), STAT5A(3), STAT5B(2), TGFA(1) 26154850 132 67 130 42 49 9 29 26 19 0 0.553 1.000 1.000 371 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(1), ACTN2(1), ACTN4(1), ARHGAP5(3), BCAR1(2), CDC42(1), CDH5(2), CLDN11(1), CLDN16(1), CLDN18(1), CLDN19(1), CLDN2(1), CLDN5(1), CLDN7(1), CTNNA1(5), CTNNA2(2), CTNNA3(2), CTNND1(4), CYBB(2), ESAM(2), EZR(1), GNAI2(1), GNAI3(1), ICAM1(1), ITGA4(2), ITGAL(3), ITGAM(4), ITGB1(5), ITGB2(3), JAM2(2), MAPK12(2), MLLT4(5), MSN(3), MYL7(1), MYL9(1), NCF4(3), NOX1(2), NOX3(2), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), PLCG1(1), PLCG2(4), PRKCG(5), PTK2(1), PTK2B(1), PTPN11(2), PXN(1), RAC1(1), RAC2(1), RAPGEF3(2), RAPGEF4(3), RHOA(2), RHOH(2), ROCK2(4), SIPA1(2), TXK(1), VAV1(1), VAV2(1), VAV3(5), VCAM1(2) 31651055 133 66 131 49 53 9 22 24 25 0 0.802 1.000 1.000 372 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(1), AKT2(3), AKT3(1), BAD(1), CDC42(1), CDK2(1), CDKN2A(2), CREB3(3), EBP(1), ERBB4(5), F2RL2(1), GAB1(2), GSK3A(1), GSK3B(2), IFI27(1), IGFBP1(1), INPPL1(3), IRS1(1), IRS2(2), MET(16), NOLC1(2), PAK1(1), PAK3(1), PAK4(2), PAK6(3), PAK7(1), PARD3(2), PIK3CA(2), PIK3CD(1), PREX1(7), PTEN(5), PTK2(1), PTPN1(2), RPS6KA1(2), RPS6KA2(3), RPS6KA3(2), SFN(1), SHC1(1), SLC2A4(1), SOS1(3), SOS2(3), TSC1(3), TSC2(6), YWHAE(1) 19523173 105 66 102 34 28 9 25 27 16 0 0.621 1.000 1.000 373 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(6), ACTN1(1), ACTR2(1), ACTR3(1), AKT1(1), AKT2(3), AKT3(1), ARHGEF6(5), BCAR1(2), BRAF(2), CAV1(1), CDC42(1), CDKN2A(2), CSE1L(4), DOCK1(5), GRB7(1), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGA9(2), ITGB3BP(1), MAP2K7(2), MAP3K11(1), MAPK10(2), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(4), MAPK9(2), P4HB(2), PAK1(1), PAK3(1), PAK4(2), PAK6(3), PAK7(1), PIK3CA(2), PIK3CB(1), PKLR(1), PLCG1(1), PLCG2(4), PTEN(5), PTK2(1), RAF1(2), ROCK2(4), SHC1(1), SOS1(3), SOS2(3), SRC(2), TLN1(10), TLN2(5), WAS(2), ZYX(1) 31131918 137 66 136 61 51 14 26 26 20 0 0.987 1.000 1.000 374 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(1), AKT2(3), AKT3(1), BCL10(1), CARD11(3), CBL(2), CBLB(3), CBLC(1), CD3G(1), CD4(2), CDC42(1), CDK4(1), CHUK(3), CTLA4(2), FOS(1), GRAP2(1), HRAS(1), ICOS(1), IKBKB(3), IL10(1), KRAS(2), LAT(2), LCP2(3), MALT1(2), MAP3K14(2), MAP3K8(1), NCK2(2), NFAT5(3), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), NFKB1(3), NFKB2(3), NFKBIA(2), NRAS(1), PAK1(1), PAK3(1), PAK4(2), PAK6(3), PAK7(1), PDCD1(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), PLCG1(1), PPP3CA(3), PPP3CB(1), PRKCQ(2), PTPRC(2), RASGRP1(2), RHOA(2), SOS1(3), SOS2(3), TNF(1), VAV1(1), VAV2(1), VAV3(5), ZAP70(2) 25680580 122 65 119 29 48 8 23 21 22 0 0.153 1.000 1.000 375 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(1), ADCY2(6), ADCY3(3), ADCY4(5), ADCY5(6), ADCY6(2), ADCY8(4), ADCY9(7), AKAP1(2), AKAP10(2), AKAP11(1), AKAP12(3), AKAP3(2), AKAP5(1), AKAP6(6), AKAP8(1), AKAP9(5), ARHGEF1(2), CHMP1B(1), GNA11(1), GNA12(1), GNA13(2), GNA14(1), GNAI2(1), GNAI3(1), GNAZ(2), GNB1(2), GNG12(1), HRAS(1), ITPR1(9), KCNJ3(2), KRAS(2), NRAS(1), PALM2(1), PDE1C(1), PDE4A(2), PDE4B(1), PDE4C(1), PDE4D(1), PDE7B(1), PDE8A(1), PDE8B(2), PLCB3(3), PPP3CA(3), PRKACA(2), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCD(3), PRKCE(2), PRKCG(5), PRKCI(4), PRKCQ(2), PRKD1(3), PRKD3(1), RHOA(2), RRAS(1), USP5(2) 29593464 136 64 134 48 60 8 26 17 25 0 0.651 1.000 1.000 376 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(6), ATM(6), BUB1(1), CCNA1(1), CCNB1(1), CCNB2(1), CCNB3(2), CCNE1(2), CCNE2(1), CCNH(1), CDAN1(4), CDC14A(2), CDC14B(1), CDC20(3), CDC25C(1), CDC6(2), CDC7(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(2), CHEK1(2), CHEK2(2), DTX4(3), E2F2(2), E2F3(2), E2F5(1), EP300(11), ESPL1(6), GSK3B(2), HDAC4(3), HDAC5(3), HDAC6(4), HDAC8(2), MAD1L1(1), MAD2L2(1), MCM2(3), MCM3(2), MCM4(3), MCM5(2), MCM6(3), MCM7(2), MDM2(1), MPEG1(1), MPL(2), PLK1(1), PRKDC(4), PTPRA(1), RBL1(2), SKP2(1), SMAD4(2), TBC1D8(2), TFDP1(1), TGFB1(2), TP53(7), WEE1(1) 27975730 129 63 128 47 65 9 24 15 16 0 0.762 1.000 1.000 377 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(1), ADCY8(4), ARAF(1), BRAF(2), CACNA1C(9), CAMK2A(4), CAMK2B(1), CAMK4(1), CREBBP(5), EP300(11), GRIA1(2), GRIA2(2), GRIN2A(2), GRIN2B(5), GRIN2C(1), GRIN2D(3), GRM5(1), HRAS(1), ITPR1(9), ITPR2(6), ITPR3(4), KRAS(2), MAP2K2(1), NRAS(1), PLCB1(2), PLCB2(4), PLCB3(3), PLCB4(2), PPP1CA(2), PPP1CC(1), PPP1R12A(1), PPP3CA(3), PPP3CB(1), PRKACA(2), PRKACB(1), PRKACG(1), PRKCG(5), PRKX(3), RAF1(2), RAPGEF3(2), RPS6KA1(2), RPS6KA2(3), RPS6KA3(2), RPS6KA6(3) 25474461 124 62 122 50 54 9 26 19 16 0 0.896 1.000 1.000 378 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(7), BAD(1), CABIN1(6), CAMK2B(1), CAMK4(1), CD3G(1), CDKN1A(1), CNR1(1), CREBBP(5), CSNK2A1(5), CSNK2B(2), CTLA4(2), EP300(11), FCER1A(1), FCGR3A(2), FKBP1B(1), FOS(1), FOSL1(1), GSK3A(1), GSK3B(2), HRAS(1), ICOS(1), IL10(1), IL1B(1), IL2RA(1), JUNB(2), MAP2K7(2), MAPK9(2), MEF2A(2), NCK2(2), NFAT5(3), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), NFKB2(3), NUP214(5), OPRD1(1), P2RX7(1), PAK1(1), PIN1(1), PPIA(1), PPP3CB(1), PTPRC(2), RELA(2), SFN(1), TGFB1(2), TNF(1), TRAF2(1), TRPV6(3), VAV1(1), VAV2(1), VAV3(5), XPO5(1) 23064458 116 60 113 35 52 7 15 22 20 0 0.494 1.000 1.000 379 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(1), ALG10B(1), ALG12(1), ALG2(2), ALG3(1), ALG6(3), ALG9(2), B3GNT1(1), B3GNT6(3), B4GALT1(1), B4GALT2(1), B4GALT3(1), B4GALT5(1), B4GALT7(1), CHPF(2), CHST1(1), CHST11(1), CHST2(3), CHST3(1), CHST6(1), CHST7(1), DDOST(1), DPAGT1(2), EXT2(2), EXTL1(1), FUT11(2), GALNT10(2), GALNT11(2), GALNT14(2), GALNT2(5), GALNT3(1), GALNT4(1), GALNT5(2), GALNT6(3), GALNT7(1), GALNT9(1), GALNTL5(1), GCNT3(2), GCNT4(1), HS2ST1(2), HS3ST2(1), HS3ST3A1(1), HS6ST2(3), HS6ST3(1), MAN1B1(1), MAN1C1(3), MAN2A1(1), MGAT1(1), MGAT2(1), MGAT3(1), MGAT4B(1), MGAT5(1), MGAT5B(3), NDST1(3), NDST2(1), NDST3(2), NDST4(2), OGT(2), RPN1(1), RPN2(1), ST3GAL3(2), ST3GAL4(3), ST6GAL1(1), ST6GALNAC1(1), UST(1), WBSCR17(4), XYLT1(2), XYLT2(2) 27972387 111 60 109 35 47 11 20 14 19 0 0.435 1.000 1.000 380 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM17(2), ATP6AP1(1), ATP6V0A1(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0B(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(4), ATP6V1H(1), CDC42(1), CHUK(3), CSK(1), CXCL1(1), EGFR(2), GIT1(3), HBEGF(1), IKBKB(3), JAM2(2), LYN(1), MAP3K14(2), MAPK10(2), MAPK12(2), MAPK9(2), MET(16), NFKB1(3), NFKB2(3), NFKBIA(2), NOD1(3), PAK1(1), PLCG1(1), PLCG2(4), PTPN11(2), PTPRZ1(4), RAC1(1), RELA(2), SRC(2), TCIRG1(2), TJP1(5) 17819853 97 60 94 31 30 13 16 22 16 0 0.639 1.000 1.000 381 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR1(3), ACVR2A(3), ACVR2B(2), AMH(2), AMHR2(3), BMP4(1), BMP6(1), BMP7(1), BMP8A(2), BMP8B(2), BMPR1A(1), BMPR1B(1), CHRD(3), CREBBP(5), CUL1(4), E2F5(1), EP300(11), FST(3), GDF5(2), GDF7(1), ID1(1), INHBA(1), INHBB(1), LEFTY1(2), LTBP1(6), NODAL(2), NOG(1), PPP2CB(1), PPP2R1A(1), PPP2R2A(2), PPP2R2C(2), RBL1(2), RBL2(4), RBX1(1), RHOA(2), ROCK2(4), SKP1(1), SMAD1(2), SMAD2(2), SMAD4(2), SMAD6(2), SMAD7(2), TFDP1(1), TGFB1(2), TGFBR1(1), TGFBR2(1), THBS1(5), THBS2(5), THBS3(5), TNF(1), ZFYVE9(2) 25069407 119 59 117 40 48 13 22 19 17 0 0.737 1.000 1.000 382 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 ALG2(2), BAK1(1), BFAR(1), CAD(5), CASP10(2), CASP8AP2(6), CD7(1), CSNK1A1(1), DAXX(2), DEDD(1), DIABLO(1), EGFR(2), FADD(1), FAIM2(1), MAP2K7(2), MAP3K1(7), MAP3K5(1), MAPK10(2), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(4), MAPK9(2), MET(16), NFAT5(3), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIL1(1), PFN1(1), PTPN13(7), RALBP1(4), RIPK1(1), SMPD1(3), TNFRSF6B(1), TP53(7), TPX2(1), TRAF2(1) 18628248 103 58 100 35 35 12 24 17 15 0 0.667 1.000 1.000 383 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 81 AIFM1(1), AKT1(1), AKT2(3), AKT3(1), APAF1(1), ATM(6), BAD(1), BID(2), BIRC3(1), CAPN1(4), CAPN2(5), CASP10(2), CASP9(2), CFLAR(1), CHUK(3), CSF2RB(2), ENDOG(1), FADD(1), FASLG(2), IKBKB(3), IL1B(1), IL1R1(1), IRAK4(1), MAP3K14(2), NFKB1(3), NFKB2(3), NFKBIA(2), NTRK1(5), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), PPP3CA(3), PPP3CB(1), PRKACA(2), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), RELA(2), RIPK1(1), TNF(1), TNFRSF10A(1), TNFRSF10D(1), TNFSF10(3), TP53(7), TRADD(1), TRAF2(1) 21264887 104 57 103 38 40 10 18 19 17 0 0.869 1.000 1.000 384 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(3), BDKRB1(1), BDKRB2(1), C1QB(1), C1QC(1), C1R(2), C1S(1), C2(2), C3(3), C3AR1(2), C4BPB(1), C5(1), C5AR1(1), C6(2), C7(2), C8A(1), C8G(1), CD46(1), CD55(1), CD59(1), CFB(1), CFD(1), CFH(2), CFI(1), CPB2(1), CR1(1), CR2(4), F10(1), F12(5), F13A1(2), F13B(2), F2(1), F2R(1), F5(3), F7(2), F8(5), FGA(1), FGB(1), KLKB1(1), KNG1(2), MASP1(1), MASP2(1), MBL2(1), PLAT(2), PLAU(1), PLAUR(1), PLG(2), PROS1(2), SERPINA1(1), SERPIND1(1), SERPINE1(1), SERPINF2(1), TFPI(1), THBD(2), VWF(7) 22887242 92 57 92 35 37 8 19 19 9 0 0.911 1.000 1.000 385 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 CAD(5), CDA(1), DCK(1), DPYD(4), DPYS(4), DTYMK(1), ENTPD1(1), ENTPD5(4), ENTPD6(2), NME1(1), NME7(1), NT5C1A(1), NT5C1B(1), NT5C2(1), PNPT1(3), POLA1(5), POLA2(1), POLD1(4), POLD2(2), POLD4(1), POLR1A(1), POLR1B(2), POLR1C(1), POLR1D(1), POLR2A(4), POLR2B(4), POLR2F(1), POLR2I(1), POLR2J(1), POLR3A(3), POLR3B(3), POLR3GL(1), PRIM1(1), PRIM2(3), RFC5(2), RRM1(3), TK2(1), TXNRD1(2), TXNRD2(1), TYMS(1), UPRT(3) 20617968 84 54 84 37 31 9 17 10 17 0 0.976 1.000 1.000 386 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(3), ALPL(3), ALPP(2), ALPPL2(1), ASCC3(1), ATP13A2(4), DDX23(2), DDX4(3), DDX41(3), DDX47(3), DDX50(3), DDX51(2), DDX52(1), DDX54(2), DDX55(1), DDX56(3), DHX58(3), ENTPD7(6), EP400(6), ERCC2(5), ERCC3(3), GCH1(1), IFIH1(3), MOV10L1(2), NUDT5(2), QDPR(1), RAD54B(3), RUVBL2(2), SETX(2), SKIV2L2(2), SMARCA2(2), SMARCA5(3) 15884759 83 54 83 26 39 6 14 17 7 0 0.412 1.000 1.000 387 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 APAF1(1), ATM(6), ATR(4), BAI1(3), BBC3(1), BID(2), CASP9(2), CCNB1(1), CCNB2(1), CCNB3(2), CCNE1(2), CCNE2(1), CCNG1(1), CCNG2(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(2), CHEK1(2), CHEK2(2), GADD45B(1), GADD45G(1), GTSE1(2), IGFBP3(1), MDM2(1), MDM4(1), PPM1D(2), PTEN(5), RCHY1(2), RFWD2(2), RPRM(1), SERPINB5(1), SERPINE1(1), SESN1(1), SESN2(1), SESN3(2), SFN(1), STEAP3(2), THBS1(5), TP53(7), TSC2(6), ZMAT3(2) 16568171 85 54 85 28 28 6 12 19 20 0 0.665 1.000 1.000 388 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 84 ANPEP(5), CD14(1), CD19(5), CD1C(1), CD2(1), CD22(2), CD34(1), CD36(1), CD37(1), CD38(1), CD3G(1), CD4(2), CD5(1), CD55(1), CD59(1), CD7(1), CD9(1), CR1(1), CR2(4), CSF1(1), CSF1R(2), CSF2RA(2), CSF3R(1), EPOR(3), FCER2(1), FCGR1A(2), GP9(1), IL1B(1), IL1R1(1), IL1R2(3), IL2RA(1), IL4R(1), IL5RA(2), IL7R(1), IL9R(5), ITGA1(3), ITGA2(2), ITGA2B(1), ITGA3(3), ITGA4(2), ITGA5(1), ITGA6(3), ITGAM(4), ITGB3(3), KIT(1), MME(2), TFRC(2), THPO(2), TNF(1), TPO(1) 20742074 91 54 91 34 40 10 13 12 16 0 0.863 1.000 1.000 389 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(5), ACSL1(2), ACSL4(1), ACSL5(1), ACSL6(4), AKT1(1), AKT2(3), AKT3(1), CAMKK1(5), CAMKK2(2), CD36(1), CHUK(3), CPT1A(2), CPT1B(1), CPT2(1), G6PC2(1), IKBKB(3), IRS1(1), IRS2(2), JAK1(4), JAK2(3), JAK3(4), LEP(2), LEPR(2), MAPK10(2), MAPK9(2), NFKB1(3), NFKB2(3), NFKBIA(2), PCK1(1), PCK2(1), POMC(1), PPARGC1A(4), PRKAB1(1), PRKAG1(1), PRKAG2(3), PRKAG3(1), PRKCQ(2), PTPN11(2), RELA(2), RXRA(2), RXRB(2), RXRG(2), SLC2A1(1), SLC2A4(1), STAT3(1), STK11(3), TNF(1), TNFRSF1B(1), TRADD(1), TRAF2(1), TYK2(2) 21103362 104 53 102 39 45 9 19 12 19 0 0.689 1.000 1.000 390 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1), AGK(1), AGPAT1(1), AGPAT3(2), AGPAT6(1), AKR1A1(4), AKR1B1(1), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), CEL(3), DAK(1), DGAT1(2), DGAT2(1), DGKA(1), DGKB(1), DGKD(3), DGKE(1), DGKG(4), DGKH(5), DGKQ(2), DGKZ(8), GLA(1), GLB1(1), GPAM(2), LCT(5), LIPA(3), LIPG(2), LPL(1), PNLIP(1), PNLIPRP1(1), PNPLA3(1), PPAP2C(1) 14968351 80 52 79 34 36 7 13 13 11 0 0.881 1.000 1.000 391 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(1), INPP4A(3), INPP4B(4), INPP5B(2), INPP5E(1), INPPL1(3), ITPK1(1), ITPKA(3), ITPKB(3), MINPP1(2), MIOX(1), OCRL(5), PI4KA(5), PI4KB(1), PIK3C3(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIP4K2A(2), PIP5K1A(1), PIP5K1B(1), PIP5K1C(3), PLCB1(2), PLCB2(4), PLCB3(3), PLCB4(2), PLCD1(5), PLCD3(1), PLCE1(2), PLCG1(1), PLCG2(4), PLCZ1(1), PTEN(5), SYNJ1(4), SYNJ2(2) 18872765 85 52 84 30 37 8 10 13 17 0 0.783 1.000 1.000 392 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(1), AKT2(3), AKT3(1), FCER1A(1), FCER1G(1), GAB2(3), HRAS(1), INPP5D(1), KRAS(2), LAT(2), LCP2(3), LYN(1), MAP2K2(1), MAP2K3(2), MAP2K7(2), MAPK10(2), MAPK12(2), MAPK9(2), NRAS(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), PLA2G12A(2), PLA2G2D(3), PLA2G3(1), PLA2G4A(3), PLA2G6(3), PLCG1(1), PLCG2(4), PRKCD(3), PRKCE(2), RAC1(1), RAC2(1), RAF1(2), SOS1(3), SOS2(3), SYK(2), TNF(1), VAV1(1), VAV2(1), VAV3(5) 18222691 88 52 84 29 33 6 21 12 16 0 0.688 1.000 1.000 393 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(2), ATP4A(2), ATP5A1(1), ATP5B(2), ATP5F1(1), ATP5G2(1), ATP5J2(1), ATP5L(1), ATP6AP1(1), ATP6V0A1(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0B(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(4), ATP6V1H(1), COX10(3), COX15(2), COX4I2(2), COX5A(1), COX7A1(1), COX8A(1), NDUFA11(2), NDUFB10(1), NDUFB11(1), NDUFB2(1), NDUFB4(1), NDUFB5(3), NDUFB6(2), NDUFB7(1), NDUFB8(1), NDUFS1(2), NDUFS2(1), NDUFS3(1), NDUFS6(1), NDUFS7(3), NDUFV1(2), SDHA(4), SDHB(2), SDHD(2), TCIRG1(2), UQCRB(1), UQCRFS1(1) 14209228 74 51 73 25 27 6 12 17 12 0 0.666 1.000 1.000 394 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(1), AKT2(3), AKT3(1), BAD(1), CASP9(2), CDC42(1), HRAS(1), KDR(4), KRAS(2), MAP2K2(1), MAPK12(2), MAPKAPK3(1), NFAT5(3), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), NOS3(3), NRAS(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), PLA2G12A(2), PLA2G2D(3), PLA2G3(1), PLA2G4A(3), PLA2G6(3), PLCG1(1), PLCG2(4), PPP3CA(3), PPP3CB(1), PRKCG(5), PTGS2(2), PTK2(1), PXN(1), RAC1(1), RAC2(1), RAF1(2), SHC2(5), SPHK1(2), SRC(2), VEGFA(1) 18352659 96 51 95 26 39 6 17 17 17 0 0.281 1.000 1.000 395 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(1), AKT2(3), AKT3(1), BCL10(1), BLNK(1), CARD11(3), CD19(5), CD22(2), CD81(1), CHUK(3), CR2(4), FCGR2B(2), FOS(1), GSK3B(2), HRAS(1), IFITM1(1), IKBKB(3), INPP5D(1), KRAS(2), LILRB3(1), LYN(1), MALT1(2), NFAT5(3), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), NFKB1(3), NFKB2(3), NFKBIA(2), NRAS(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), PLCG2(4), PPP3CA(3), PPP3CB(1), RAC1(1), RAC2(1), RASGRP3(1), SYK(2), VAV1(1), VAV2(1), VAV3(5) 18877267 99 51 96 30 43 7 15 17 17 0 0.513 1.000 1.000 396 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(5), ADCY6(2), ADCY8(4), CACNA1A(10), CACNA1B(7), GNAS(3), GNB1(2), GRM4(6), ITPR3(4), KCNB1(2), PLCB2(4), PRKACA(2), PRKACB(1), PRKACG(1), PRKX(3), SCNN1A(1), SCNN1B(3), TAS1R1(2), TAS1R2(4), TAS1R3(1), TAS2R13(1), TAS2R14(2), TAS2R16(1), TAS2R39(1), TAS2R41(2), TAS2R43(1), TAS2R50(1), TRPM5(1) 14543637 77 51 76 31 37 3 19 6 12 0 0.607 1.000 1.000 397 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 85 ATF2(1), BRAF(2), CEBPA(1), CHUK(3), DAXX(2), FOS(1), HRAS(1), IKBKB(3), MAP2K2(1), MAP2K3(2), MAP2K5(3), MAP2K7(2), MAP3K1(7), MAP3K10(1), MAP3K11(1), MAP3K12(1), MAP3K14(2), MAP3K2(1), MAP3K4(1), MAP3K5(1), MAP3K6(5), MAP3K7(1), MAP3K8(1), MAP3K9(5), MAP4K1(3), MAP4K2(1), MAP4K3(5), MAP4K4(7), MAP4K5(2), MAPK10(2), MAPK12(2), MAPK4(1), MAPK6(1), MAPK7(3), MAPK9(2), MAPKAPK3(1), MAX(1), MEF2A(2), NFKB1(3), NFKBIA(2), PAK1(1), RAC1(1), RAF1(2), RELA(2), RIPK1(1), RPS6KA1(2), RPS6KA2(3), RPS6KA3(2), RPS6KA4(1), SHC1(1), STAT1(2), TGFB1(2), TGFBR1(1), TRADD(1), TRAF2(1) 24479092 110 51 107 45 51 10 11 17 20 1 0.948 1.000 1.000 398 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(2), APH1A(1), CREBBP(5), CTBP1(3), CTBP2(5), DLL1(1), DLL4(3), DTX1(1), DTX2(1), DTX3L(1), DTX4(3), DVL2(1), DVL3(3), EP300(11), JAG1(5), JAG2(1), LFNG(2), MAML1(6), MAML2(5), MAML3(3), MFNG(1), NCOR2(8), NCSTN(2), NOTCH1(8), NOTCH2(7), NOTCH3(7), NOTCH4(2), NUMB(2), NUMBL(2), PSEN1(2), PSEN2(1), PTCRA(3), RBPJ(2), RBPJL(2) 17851412 112 50 110 59 56 15 14 8 18 1 0.999 1.000 1.000 399 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(1), AKT2(3), AKT3(1), CCL4(1), CD14(1), CD40(1), CD86(3), CHUK(3), CXCL11(1), FADD(1), FOS(1), IFNA16(1), IFNA2(1), IFNAR1(2), IKBKB(3), IKBKE(3), IL1B(1), IRAK4(1), IRF5(2), IRF7(1), LBP(1), LY96(1), MAP2K2(1), MAP2K3(2), MAP2K7(2), MAP3K7(1), MAP3K8(1), MAPK10(2), MAPK12(2), MAPK9(2), NFKB1(3), NFKB2(3), NFKBIA(2), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), RAC1(1), RELA(2), RIPK1(1), STAT1(2), TLR1(2), TLR2(2), TLR3(1), TLR4(3), TLR5(3), TLR6(1), TLR7(5), TNF(1), TOLLIP(1) 22655203 94 50 93 32 39 10 15 15 14 1 0.728 1.000 1.000 400 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(11), CDR1(2), FAU(2), IL6ST(3), PIGK(2), RPL10(2), RPL11(2), RPL13(1), RPL14(1), RPL18(2), RPL19(1), RPL21(2), RPL22(1), RPL24(1), RPL26(1), RPL29(1), RPL3(2), RPL3L(1), RPL6(1), RPL7A(3), RPL9(2), RPLP0(1), RPLP2(1), RPS10(1), RPS13(1), RPS14(1), RPS16(1), RPS2(1), RPS24(2), RPS27A(1), RPS3A(1), RPS4X(3), RPS6KA1(2), RPS6KA2(3), RPS6KA3(2), RPS6KA6(3), RPS7(1), RPS8(2), RPSA(1), SLC36A2(1), TBC1D10C(2), UBA52(2) 13205426 77 50 73 28 31 10 9 14 13 0 0.810 1.000 1.000 401 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(1), BAD(1), BAK1(1), BCL2L11(1), BID(2), BIRC3(1), BIRC5(1), CASP1(1), CASP10(2), CASP4(2), CASP9(2), CHUK(3), FADD(1), FASLG(2), HELLS(2), IKBKB(3), IRF1(1), IRF2(1), IRF4(1), IRF5(2), IRF6(1), IRF7(1), LTA(1), MAP3K1(7), MAPK10(2), MDM2(1), NFKB1(3), NFKBIA(2), PLEKHG5(2), PRF1(2), RELA(2), RIPK1(1), TNF(1), TNFRSF1B(1), TNFRSF21(3), TNFRSF25(1), TNFSF10(3), TP53(7), TRADD(1), TRAF1(2), TRAF2(1) 14571186 76 48 76 25 26 8 15 14 13 0 0.681 1.000 1.000 402 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(6), CCNA1(1), CCNB1(1), CCNE1(2), CCNE2(1), CCNG2(1), CCNH(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(2), CREB3(3), CREB3L3(1), CREB3L4(1), E2F2(2), E2F3(2), E2F5(1), GBA2(1), MCM2(3), MCM3(2), MCM4(3), MCM5(2), MCM6(3), MCM7(2), MDM2(1), MYT1(7), NACA(5), POLA2(1), PRIM1(1), RBL1(2), RPA1(1), TFDP1(1), TNXB(13), TP53(7), WEE1(1) 19542960 84 48 82 25 48 5 13 11 7 0 0.240 1.000 1.000 403 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1), AGPAT1(1), AGPAT3(2), AKR1A1(4), AKR1B1(1), ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), CEL(3), DGAT1(2), DGKA(1), DGKB(1), DGKD(3), DGKE(1), DGKG(4), DGKH(5), DGKQ(2), DGKZ(8), GLA(1), GLB1(1), LCT(5), LIPG(2), LPL(1), PNLIP(1), PNLIPRP1(1), PPAP2C(1) 12310981 72 46 71 25 36 7 10 11 8 0 0.585 1.000 1.000 404 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(3), ACSS2(1), ACYP1(1), ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1), AKR1A1(4), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH3B1(1), ALDH3B2(2), ALDH9A1(1), ALDOB(3), ALDOC(1), BPGM(1), DLD(3), G6PC2(1), GALM(3), GAPDH(2), GAPDHS(4), GCK(2), HK1(1), HK2(2), LDHAL6B(1), LDHB(1), PFKL(4), PFKP(3), PGAM2(1), PGK2(1), PGM1(2), PGM3(1), PKLR(1), TPI1(3) 14702458 72 46 71 30 34 7 10 9 11 1 0.859 1.000 1.000 405 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP4(1), BMP6(1), BMP7(1), BMP8A(2), BMP8B(2), BTRC(1), CSNK1A1(1), CSNK1D(1), CSNK1E(3), FBXW11(2), GLI1(4), GLI2(1), GLI3(3), GSK3B(2), IHH(3), LRP2(9), PRKACA(2), PRKACB(1), PRKACG(1), PRKX(3), PTCH1(1), PTCH2(1), SHH(1), STK36(2), SUFU(3), WNT10A(2), WNT10B(1), WNT16(1), WNT2(1), WNT2B(1), WNT3(2), WNT5B(1), WNT8A(1), WNT8B(2), ZIC2(1) 15323518 65 46 64 36 30 7 15 4 9 0 0.993 1.000 1.000 406 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(1), AKT2(3), AKT3(1), BAD(1), BCR(3), BLNK(1), CD19(5), CD22(2), CD81(1), CR2(4), CSK(1), DAG1(6), FLOT1(1), GSK3A(1), GSK3B(2), INPP5D(1), ITPR1(9), ITPR2(6), ITPR3(4), LYN(1), MAP4K1(3), NFATC1(1), NFATC2(3), PIK3CA(2), PIK3CD(1), PIK3R1(3), PLCG2(4), PPP3CA(3), PPP3CB(1), PTPRC(2), RAF1(2), SHC1(1), SOS1(3), SOS2(3), SYK(2), VAV1(1) 18686805 89 46 89 36 39 6 12 16 16 0 0.909 1.000 1.000 407 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(2), ALG6(3), CCKBR(2), CCR2(1), CCR3(2), CCR5(1), CELSR1(11), CELSR2(10), CELSR3(4), CHRM2(3), CHRM3(2), CIDEB(2), DRD4(2), EMR2(2), F2R(1), GHRHR(1), GNRHR(1), GPR116(3), GPR133(4), GPR135(4), GPR18(2), GPR55(1), GPR61(1), GPR84(2), GRPR(1), LGR6(2), LPHN2(2), LPHN3(2), NTSR1(1), PTGFR(2) 16831881 77 45 76 34 38 3 17 13 6 0 0.713 1.000 1.000 408 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(1), AKT2(3), AKT3(1), BRAF(2), EIF4B(2), EIF4EBP1(1), HIF1A(2), INS(3), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), RHEB(2), RICTOR(4), RPS6KA1(2), RPS6KA2(3), RPS6KA3(2), RPS6KA6(3), STK11(3), TSC1(3), TSC2(6), ULK1(1), ULK2(4), ULK3(1), VEGFA(1) 13534326 64 45 63 28 23 4 18 11 7 1 0.940 1.000 1.000 409 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(1), AKT2(3), AKT3(1), CAP1(2), CBL(2), CDC42(1), CDKN2A(2), F2RL2(1), FLOT1(1), GSK3A(1), GSK3B(2), IGFBP1(1), INPPL1(3), IRS1(1), IRS2(2), LNPEP(1), PARD3(2), PIK3CA(2), PIK3CD(1), PIK3R1(3), PTEN(5), PTPN1(2), RAF1(2), RPS6KA1(2), RPS6KA2(3), RPS6KA3(2), SERPINB6(1), SFN(1), SHC1(1), SLC2A4(1), SORBS1(3), SOS1(3), SOS2(3), YWHAE(1) 15000553 63 45 62 30 18 3 15 16 11 0 0.982 1.000 1.000 410 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(2), ATP6AP1(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(4), ATP6V1H(1), ATP7A(1), ATP7B(7), COX10(3), COX5A(1), COX7A1(1), COX8A(1), NDUFA11(2), NDUFB2(1), NDUFB4(1), NDUFB5(3), NDUFB6(2), NDUFB7(1), NDUFS1(2), NDUFS2(1), NDUFV1(2), SDHA(4), SDHB(2), SHMT1(1), UQCRB(1), UQCRFS1(1) 9661450 56 44 55 18 19 6 9 11 11 0 0.658 1.000 1.000 411 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(1), AKT2(3), AKT3(1), ASAH1(1), BRAF(2), DAG1(6), EGFR(2), ITPKA(3), ITPKB(3), ITPR1(9), ITPR2(6), ITPR3(4), KCNJ3(2), PI3(1), PIK3CB(1), PLCB1(2), PLCB2(4), PLCB3(3), PLCB4(2), RAF1(2), RGS20(3), SHC1(1), SOS1(3), SOS2(3), SRC(2), STAT3(1) 14820907 71 44 71 26 29 7 10 11 14 0 0.751 1.000 1.000 412 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 ACMSD(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), AOC2(3), AOC3(2), AOX1(1), CARM1(1), CAT(2), CYP1B1(1), DDC(3), EHHADH(2), HAAO(3), HADHA(3), HEMK1(1), HSD17B10(2), HSD17B4(1), KYNU(1), LCMT1(1), LNX1(3), MAOA(2), MAOB(4), METTL2B(1), NFX1(3), OGDH(7), OGDHL(3), PRMT2(2), PRMT3(1), PRMT5(2), PRMT6(1), PRMT7(3), TPH1(2), TPH2(1), WBSCR22(1) 15319269 78 43 77 27 35 8 14 9 12 0 0.595 1.000 1.000 413 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(3), CD36(1), CITED2(1), CPT1B(1), CREBBP(5), EHHADH(2), EP300(11), HSD17B4(1), INS(3), LPL(1), ME1(1), MRPL11(2), NCOA1(1), NCOR1(4), NCOR2(8), NFKBIA(2), NR1H3(1), NR2F1(1), PDGFA(1), PIK3CA(2), PIK3R1(3), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PTGS2(2), RELA(2), RXRA(2), STAT5A(3), STAT5B(2), TNF(1) 16014007 72 43 71 31 32 6 13 7 14 0 0.977 1.000 1.000 414 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(1), ACTR3(1), AKT1(1), AKT2(3), AKT3(1), ARHGAP1(1), ARHGEF11(5), CDC42(1), CFL2(1), GDI1(1), INPPL1(3), ITPR1(9), ITPR2(6), ITPR3(4), LIMK1(6), PAK1(1), PAK3(1), PAK4(2), PAK6(3), PAK7(1), PIK3CA(2), PIK3CD(1), PIK3CG(2), PIK3R1(3), PTEN(5), ROCK2(4), RPS4X(3), WASF1(1) 17786009 73 43 72 31 29 11 15 7 11 0 0.920 1.000 1.000 415 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(1), APC(1), AR(4), ASAH1(1), BRAF(2), CAMP(1), CCL15(1), DAG1(6), EGFR(2), GNA11(1), ITPKA(3), ITPKB(3), ITPR1(9), ITPR2(6), ITPR3(4), KCNJ3(2), MAPK10(2), PHKA2(3), PIK3CA(2), PIK3CD(1), PIK3R1(3), RAF1(2), SRC(2) 13557391 62 43 62 21 22 7 9 11 13 0 0.715 1.000 1.000 416 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(1), AXIN1(5), CSNK1E(3), DVL2(1), DVL3(3), FBXW2(1), FOSL1(1), FZD1(2), FZD10(1), FZD5(2), FZD7(1), GSK3B(2), LDLR(2), MAPK10(2), MAPK9(2), PLAU(1), PPP2R5C(3), PPP2R5E(1), PRKCD(3), PRKCE(2), PRKCG(5), PRKCI(4), PRKCQ(2), PRKD1(3), RAC1(1), RHOA(2), SFRP4(1), TCF7(3), WNT10A(2), WNT10B(1), WNT16(1), WNT2(1), WNT2B(1), WNT3(2), WNT5B(1) 15057867 69 43 68 24 28 8 14 6 13 0 0.559 1.000 1.000 417 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 AGPAT1(1), AGPAT3(2), AGPS(7), CDIPT(1), CDS2(2), CHKA(1), CHKB(1), CPT1B(1), DGKA(1), DGKB(1), DGKD(3), DGKE(1), DGKG(4), DGKH(5), DGKQ(2), DGKZ(8), GPD1(1), LCAT(2), LGALS13(1), PAFAH2(2), PCYT1A(2), PCYT1B(2), PEMT(3), PISD(1), PLA2G3(1), PLA2G4A(3), PLA2G6(3), PLCB2(4), PLCG1(1), PLCG2(4), PPAP2C(1) 12796164 72 42 72 23 30 12 10 7 13 0 0.470 1.000 1.000 418 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(4), ACADL(4), ACOX1(3), ACOX2(3), ACOX3(6), ACSL1(2), ACSL4(1), ACSL5(1), ACSL6(4), APOC3(1), AQP7(3), CD36(1), CPT1A(2), CPT1B(1), CPT2(1), CYP27A1(2), CYP4A11(2), CYP4A22(1), CYP7A1(2), EHHADH(2), FABP2(1), FABP3(1), FABP5(1), LPL(1), ME1(1), MMP1(1), NR1H3(1), PCK1(1), PCK2(1), PLTP(1), PPARD(1), RXRA(2), RXRB(2), RXRG(2), SCP2(3), SLC27A1(4), SLC27A4(2), SLC27A5(1), SLC27A6(2), SORBS1(3) 16514253 78 42 78 29 39 5 14 9 10 1 0.731 1.000 1.000 419 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP4A(3), INPP4B(4), INPPL1(3), ITPKA(3), ITPKB(3), MIOX(1), OCRL(5), PIK3C2A(5), PIK3C2B(5), PIK3C2G(6), PIK3CA(2), PIK3CB(1), PIK3CG(2), PLCB1(2), PLCB2(4), PLCB3(3), PLCB4(2), PLCD1(5), PLCG1(1), PLCG2(4) 11383736 64 42 63 21 31 5 10 8 10 0 0.615 1.000 1.000 420 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(4), COL4A2(4), COL4A3(6), COL4A4(10), COL4A5(5), COL4A6(6), F10(1), F12(5), F2(1), F2R(1), F5(3), F8(5), FGA(1), FGB(1), KLKB1(1), PROS1(2) 11278830 56 41 56 23 27 3 7 9 9 1 0.994 1.000 1.000 421 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(5), CDA(1), DCK(1), DPYD(4), DPYS(4), DTYMK(1), ENTPD1(1), NME1(1), POLB(2), POLD1(4), POLD2(2), POLG(6), POLQ(8), POLR1B(2), POLR2A(4), POLR2B(4), POLR2F(1), POLR2I(1), POLR2J(1), POLRMT(2), RRM1(3), TK2(1), TXNRD1(2), TYMS(1) 14593639 62 41 62 21 19 8 10 9 16 0 0.797 1.000 1.000 422 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(4), AMY2B(1), ENPP1(6), ENPP3(1), GAA(2), GBA3(1), GBE1(3), GCK(2), GYS1(2), GYS2(2), HK1(1), HK2(2), MGAM(6), PGM1(2), PGM3(1), PYGB(2), PYGL(2), PYGM(4), SI(4), UCHL1(1), UGDH(1), UGT1A1(1), UGT1A3(1), UGT1A5(2), UGT1A9(2) 14451683 56 41 56 28 18 8 8 12 10 0 0.989 1.000 1.000 423 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(1), BAK1(1), BID(2), BIRC3(1), CASP9(2), FADD(1), FASLG(2), MAP3K1(7), MAP3K14(2), MAPK10(2), MCL1(1), MDM2(1), NFKB1(3), NFKBIA(2), PARP1(5), PRF1(2), RELA(2), RIPK1(1), TNF(1), TNFRSF1B(1), TNFSF10(3), TP53(7), TRADD(1), TRAF1(2), TRAF2(1) 9466115 54 40 54 17 19 6 9 11 9 0 0.647 1.000 1.000 424 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(1), APAF1(1), BID(2), BIRC3(1), CASP9(2), CFLAR(1), CHUK(3), DAXX(2), FADD(1), GSN(2), LMNA(3), LMNB2(1), MAP2K7(2), MAP3K1(7), MAP3K14(2), MAP3K5(1), MDM2(1), NFKB1(3), NFKBIA(2), NUMA1(5), PRKCD(3), PRKDC(4), PSEN1(2), PSEN2(1), PTK2(1), RASA1(2), RELA(2), RIPK1(1), SPTAN1(6), TNF(1), TNFRSF1B(1), TRADD(1), TRAF1(2), TRAF2(1) 17642508 71 40 71 30 28 5 9 9 20 0 0.949 1.000 1.000 425 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(1), ATF2(1), CDC42(1), DLD(3), DUSP4(3), GAB1(2), GCK(2), IL1R1(1), MAP2K5(3), MAP2K7(2), MAP3K1(7), MAP3K10(1), MAP3K11(1), MAP3K12(1), MAP3K2(1), MAP3K4(1), MAP3K5(1), MAP3K7(1), MAP3K9(5), MAPK10(2), MAPK7(3), MAPK9(2), MYEF2(1), NFATC3(3), NR2C2(3), PAPPA(4), SHC1(1), TP53(7), ZAK(2) 12721428 66 40 63 24 31 8 11 6 8 2 0.816 1.000 1.000 426 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(1), ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH4A1(3), ALDH9A1(1), AMD1(2), AOC2(3), AOC3(2), ARG1(1), ARG2(1), CKB(2), CPS1(2), GATM(3), GOT1(2), GOT2(2), MAOA(2), MAOB(4), NOS1(4), NOS3(3), OAT(1), OTC(1), P4HA1(1), P4HB(2), RARS(1), SMS(1) 11230405 59 39 59 19 27 7 7 10 8 0 0.407 1.000 1.000 427 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1), AKR1C1(1), AKR1C2(1), AKR1C3(2), ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), CYP1B1(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2F1(1), CYP3A4(2), CYP3A43(2), CYP3A7(1), DHDH(4), EPHX1(1), GSTA1(1), GSTA2(1), GSTA3(1), GSTA5(2), GSTK1(1), GSTM1(1), GSTM4(1), GSTO2(1), GSTP1(2), GSTT1(2), MGST2(1), UGT1A1(1), UGT1A3(1), UGT1A5(2), UGT1A9(2), UGT2A1(4), UGT2A3(1), UGT2B10(1), UGT2B17(1), UGT2B28(1), UGT2B7(2) 14532126 59 39 59 23 20 8 10 15 6 0 0.897 1.000 1.000 428 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(1), AKT2(3), AKT3(1), BCR(3), CD19(5), CDKN2A(2), DAPP1(2), FLOT1(1), GAB1(2), ITPR1(9), ITPR2(6), ITPR3(4), LYN(1), PHF11(1), PIK3CA(2), PLCG2(4), PREX1(7), PTEN(5), PTPRC(2), RPS6KA1(2), RPS6KA2(3), RPS6KA3(2), SYK(2), VAV1(1) 14026349 71 39 70 32 28 6 10 13 14 0 0.947 1.000 1.000 429 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(1), ASAH1(1), BRAF(2), CAMP(1), CREB3(3), CREBBP(5), CRKL(1), DAG1(6), FRS2(1), MAP1B(5), MAP2K7(2), MAPK10(2), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(4), MAPK9(2), NTRK1(5), PIK3C2G(6), PIK3CA(2), PIK3CD(1), PIK3R1(3), PTPN11(2), RPS6KA3(2), SHC1(1), SRC(2) 13136733 64 39 62 32 25 8 13 9 9 0 0.975 1.000 1.000 430 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(1), AKT2(3), AKT3(1), ARHGEF11(5), CDC42(1), DLG4(3), GNA13(2), LPA(6), MAP3K1(7), MAP3K5(1), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIL1(1), PHKA2(3), PI3(1), PIK3CB(1), PLD1(2), PLD2(1), PTK2(1), RDX(2), ROCK2(4), SRF(1), TBXA2R(1) 12397678 56 39 56 22 24 6 13 5 8 0 0.830 1.000 1.000 431 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ACMSD(2), ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), AOC2(3), AOC3(2), AOX1(1), CAT(2), CYP2A13(3), CYP2A6(3), CYP2A7(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2D6(1), CYP2F1(1), CYP3A4(2), CYP3A7(1), CYP4F8(1), CYP51A1(3), DDC(3), EHHADH(2), HAAO(3), HADHA(3), KYNU(1), MAOA(2), MAOB(4), TPH1(2) 13894167 64 39 63 19 31 4 15 8 6 0 0.329 1.000 1.000 432 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(1), AGT(3), AKT1(1), CALR(1), CAMK1(2), CAMK1G(1), CAMK4(1), CREBBP(5), CSNK1A1(1), F2(1), GSK3B(2), HAND2(1), HRAS(1), LIF(2), MYH2(1), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), NKX2-5(4), PIK3CA(2), PIK3R1(3), PPP3CA(3), PPP3CB(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), RAF1(2) 12776125 55 38 55 29 23 4 10 9 9 0 0.994 1.000 1.000 433 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(1), AKT2(3), AKT3(1), BAD(1), BCR(3), BLNK(1), CD19(5), CSK(1), DAG1(6), ITPKA(3), ITPKB(3), LYN(1), MAP2K2(1), NFAT5(3), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIL1(1), PI3(1), PIK3CA(2), PIK3CD(1), PIK3R1(3), PLCG2(4), RAF1(2), SHC1(1), SOS1(3), SOS2(3), SYK(2), VAV1(1) 13368146 65 38 65 24 23 5 11 12 14 0 0.813 1.000 1.000 434 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1), AKR1A1(4), ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH3B1(1), ALDH3B2(2), ALDH9A1(1), ALDOB(3), ALDOC(1), BPGM(1), DLD(3), GAPDH(2), GCK(2), HK1(1), HK2(2), LDHB(1), PFKP(3), PGM1(2), PGM3(1), PKLR(1), TPI1(3) 12320866 55 37 54 26 25 5 8 9 7 1 0.941 1.000 1.000 435 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1), AKR1A1(4), ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH3B1(1), ALDH3B2(2), ALDH9A1(1), ALDOB(3), ALDOC(1), BPGM(1), DLD(3), GAPDH(2), GCK(2), HK1(1), HK2(2), LDHB(1), PFKP(3), PGM1(2), PGM3(1), PKLR(1), TPI1(3) 12320866 55 37 54 26 25 5 8 9 7 1 0.941 1.000 1.000 436 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(2), AGXT2(1), ALAS1(1), ALAS2(2), AMT(1), AOC2(3), AOC3(2), BHMT(6), CBS(1), CHDH(2), CHKA(1), CHKB(1), CTH(2), DLD(3), GARS(1), GATM(3), GCAT(1), GLDC(3), GNMT(1), MAOA(2), MAOB(4), PEMT(3), PIPOX(3), PISD(1), PSAT1(2), RDH11(2), RDH13(1), SARDH(3), SARS2(1), SHMT1(1), SHMT2(3), TARS2(3) 10894613 66 37 66 21 29 5 11 10 10 1 0.478 1.000 1.000 437 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1), ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), AOC2(3), AOC3(2), AOX1(1), CARM1(1), DBH(1), DCT(2), DDC(3), ECH1(1), ESCO2(1), GOT1(2), GOT2(2), HEMK1(1), HGD(1), HPD(3), LCMT1(1), MAOA(2), MAOB(4), METTL2B(1), PNMT(1), PNPLA3(1), PRMT2(2), PRMT3(1), PRMT5(2), PRMT6(1), PRMT7(3), TPO(1), TYRP1(3), WBSCR22(1) 15020749 58 37 58 28 30 7 9 4 8 0 0.943 1.000 1.000 438 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 AGPAT1(1), AGPAT3(2), AGPAT6(1), CDIPT(1), CDS2(2), CHKA(1), CHKB(1), CHPT1(1), DGKA(1), DGKB(1), DGKD(3), DGKE(1), DGKG(4), DGKH(5), DGKQ(2), DGKZ(8), ESCO2(1), ETNK2(1), GPAM(2), GPD1(1), GPD1L(1), LCAT(2), PCYT1A(2), PCYT1B(2), PEMT(3), PISD(1), PLA2G12A(2), PLA2G2D(3), PLA2G3(1), PLA2G4A(3), PLA2G6(3), PLD1(2), PLD2(1), PNPLA3(1), PPAP2C(1), PTDSS1(1) 16739032 69 37 69 26 34 9 7 6 13 0 0.728 1.000 1.000 439 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(2), EGFR(2), ERBB2(3), ERBB4(5), ETS1(1), ETV6(1), ETV7(1), FMN2(2), KRAS(2), NOTCH1(8), NOTCH2(7), NOTCH3(7), NOTCH4(2), PIWIL4(2), RAF1(2), SOS1(3), SOS2(3), SPIRE2(2) 13301717 55 37 54 26 20 3 11 8 13 0 0.976 1.000 1.000 440 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(4), ACAA2(1), ACAD8(2), ACAD9(2), ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), BAAT(2), CEL(3), CYP27A1(2), CYP7A1(2), HADHB(1), LIPA(3), RDH11(2), RDH13(1), SLC27A5(1), SOAT2(1), SRD5A1(1) 8037393 47 36 47 18 24 2 7 8 6 0 0.737 1.000 1.000 441 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(2), AARS2(3), ABAT(1), ACY3(3), ADSL(2), ADSS(1), ADSSL1(2), AGXT(2), AGXT2(1), ASNS(2), ASS1(4), CAD(5), CRAT(2), DARS(3), DARS2(1), DDO(1), DLD(3), GAD1(4), GAD2(2), GOT1(2), GOT2(2), GPT(2), NARS(1), NARS2(1), PC(6) 9599061 58 36 57 19 23 3 9 9 13 1 0.625 1.000 1.000 442 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(1), AKT1(1), BDKRB2(1), CAV1(1), CHRM1(2), CHRNA1(1), FLT1(2), FLT4(5), KDR(4), NOS3(3), PDE2A(3), PDE3B(3), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKG1(1), PRKG2(3), RYR2(14), SLC7A1(4) 10409309 54 36 54 25 21 5 13 7 8 0 0.922 1.000 1.000 443 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(1), EGFR(2), IGF1R(4), POLR2A(4), TEP1(10), TERF1(3), TERT(8), TNKS(5), TP53(7), XRCC5(1) 7105881 45 36 45 14 17 5 12 3 8 0 0.397 1.000 1.000 444 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(4), ACO1(1), ACO2(3), CLYBL(1), CS(1), DLD(3), DLST(1), FH(2), IDH1(2), IDH2(4), IDH3B(3), MDH1(1), OGDH(7), OGDHL(3), PC(6), PCK1(1), PCK2(1), SDHA(4), SDHB(2), SDHD(2), SUCLA2(1), SUCLG2(1) 7533675 54 35 54 20 19 5 8 7 14 1 0.710 1.000 1.000 445 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 ARSD(2), ARSE(3), CARM1(1), CYP11B1(2), HEMK1(1), HSD11B1(1), HSD17B1(1), HSD17B7(1), LCMT1(1), METTL2B(1), PRMT2(2), PRMT3(1), PRMT5(2), PRMT6(1), PRMT7(3), SRD5A1(1), STS(4), SULT1E1(2), UGT1A1(1), UGT1A3(1), UGT1A5(2), UGT1A9(2), UGT2A1(4), UGT2A3(1), UGT2B10(1), UGT2B17(1), UGT2B28(1), UGT2B7(2), WBSCR22(1) 12641463 47 35 47 20 21 4 2 9 11 0 0.916 1.000 1.000 446 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ACY3(3), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH3B1(1), ALDH3B2(2), ALDH9A1(1), AMDHD1(2), AOC2(3), AOC3(2), CARM1(1), CNDP1(1), DDC(3), HDC(2), HEMK1(1), HNMT(1), LCMT1(1), MAOA(2), MAOB(4), METTL2B(1), PRMT2(2), PRMT3(1), PRMT5(2), PRMT6(1), PRMT7(3), PRPS1(1), PRPS2(3), UROC1(1), WBSCR22(1) 10069927 58 35 58 22 27 6 10 6 9 0 0.593 1.000 1.000 447 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(1), CALR(1), CANX(1), CD4(2), CD74(1), CIITA(6), CTSB(1), CTSL1(2), CTSS(2), HLA-A(1), HLA-B(2), HLA-C(1), HLA-DOA(1), HLA-DPB1(1), HLA-DQA2(1), HSP90AA1(3), IFNA16(1), IFNA2(1), KIR2DL4(1), KIR3DL2(1), KIR3DL3(2), KLRC1(1), KLRC2(1), KLRC3(1), LTA(1), NFYA(2), NFYC(1), PDIA3(1), PSME2(2), RFX5(1), TAP1(3), TAPBP(2) 11715626 49 35 49 22 18 5 8 4 13 1 0.949 1.000 1.000 448 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 43 CEBPA(1), CHUK(3), DAXX(2), EGF(2), EGFR(2), ETS1(1), FOS(1), HOXA7(1), HRAS(1), IKBKB(3), MAP2K3(2), MAP2K7(2), MAP3K1(7), MAP3K14(2), MAP3K5(1), NFKB1(3), NFKBIA(2), PRKCD(3), PRKCE(2), PRKCG(5), PRKCQ(2), RAF1(2), RELA(2), RIPK1(1), TNF(1), TNFRSF1B(1), TRAF2(1) 12367678 56 35 56 20 22 4 10 6 14 0 0.783 1.000 1.000 449 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(3), CARM1(1), CREBBP(5), EP300(11), ERCC3(3), ESR1(1), GRIP1(4), GTF2A1(1), HDAC4(3), HDAC5(3), HDAC6(4), NCOR2(8), PELP1(2), POLR2A(4) 11840182 53 34 52 30 26 3 11 5 8 0 0.995 1.000 1.000 450 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CAMK1(2), CAMK1G(1), GNB1(2), HRAS(1), MAP2K2(1), MAP2K3(2), MAP3K1(7), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), NFKB1(3), NFKBIA(2), PAK1(1), PIK3C2G(6), PLCB1(2), PPP3CA(3), PPP3CB(1), RAC1(1), RAF1(2), RELA(2) 9725733 50 34 50 15 21 6 6 7 10 0 0.621 1.000 1.000 451 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(6), ATR(4), BRCA1(3), CCNB1(1), CDC25C(1), CDKN1A(1), CHEK1(2), CHEK2(2), EP300(11), MDM2(1), MYT1(7), PRKDC(4), RPS6KA1(2), TP53(7), WEE1(1) 10672208 53 34 53 23 26 6 6 8 7 0 0.973 1.000 1.000 452 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(2), AGXT2(1), ALAS1(1), ALAS2(2), AMT(1), AOC2(3), AOC3(2), BHMT(6), CBS(1), CHDH(2), CHKA(1), CHKB(1), CPT1B(1), CTH(2), DLD(3), GARS(1), GATM(3), GCAT(1), GLDC(3), MAOA(2), MAOB(4), PEMT(3), PISD(1), PLCB2(4), PLCG1(1), PLCG2(4), SARDH(3), SHMT1(1), SHMT2(3) 10715480 63 34 63 20 27 6 11 9 9 1 0.447 1.000 1.000 453 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(3), ALDOC(1), DLD(3), GAPDH(2), GAPDHS(4), GCK(2), GOT1(2), GOT2(2), HK1(1), HK2(2), LDHAL6B(1), LDHB(1), MDH1(1), PC(6), PCK1(1), PDHX(1), PFKL(4), PFKP(3), PGAM2(1), PGK2(1), PKLR(1), TNFAIP1(1), TPI1(3) 10704617 47 34 47 25 16 4 6 5 15 1 0.983 1.000 1.000 454 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(2), ARSD(2), ARSE(3), ASAH1(1), B4GALT6(1), CERK(1), ENPP7(2), GAL3ST1(1), GALC(3), GBA(1), GLA(1), GLB1(1), LCT(5), NEU1(1), NEU2(1), NEU4(2), PPAP2C(1), SGMS1(2), SMPD1(3), SMPD2(2), SMPD3(2), SMPD4(4), SPHK1(2), SPTLC2(2) 9065745 46 34 46 15 16 3 12 6 9 0 0.583 1.000 1.000 455 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(5), ACACB(5), ACSS1(3), ACSS2(1), ACYP1(1), AKR1B1(1), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), DLD(3), LDHAL6B(1), LDHB(1), MDH1(1), ME1(1), ME2(1), ME3(3), PC(6), PCK1(1), PCK2(1), PKLR(1) 11804507 49 34 49 21 23 2 8 10 5 1 0.863 1.000 1.000 456 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(2), AARS2(3), CARS(1), CARS2(1), DARS(3), DARS2(1), EPRS(4), FARSA(1), GARS(1), IARS(1), IARS2(1), KARS(2), LARS(4), LARS2(1), MARS(3), MARS2(1), NARS(1), NARS2(1), PARS2(1), QARS(1), RARS(1), RARS2(3), SARS2(1), TARS2(3), VARS(3), VARS2(5), YARS2(1) 13684415 51 34 51 17 21 3 9 11 7 0 0.682 1.000 1.000 457 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), ACTN1(1), ACTN2(1), BCAR1(2), BCR(3), CAPN1(4), CAV1(1), CRKL(1), CSK(1), HRAS(1), ITGA1(3), ITGB1(5), MAP2K2(1), PPP1R12B(1), PTK2(1), PXN(1), RAF1(2), SHC1(1), SOS1(3), SRC(2), TLN1(10), ZYX(1) 11983070 47 34 47 17 15 5 8 7 12 0 0.781 1.000 1.000 458 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(2), AKT1(1), AKT2(3), AKT3(1), DAG1(6), ITPKA(3), ITPKB(3), ITPR1(9), ITPR2(6), ITPR3(4), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIL1(1), PHKA2(3), PIK3CB(1), PLD1(2), PLD2(1) 11423111 54 34 54 24 22 5 11 7 9 0 0.865 1.000 1.000 459 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CD3G(1), FOS(1), HRAS(1), LAT(2), MAP3K1(7), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), NFKB1(3), NFKBIA(2), PIK3CA(2), PIK3R1(3), PLCG1(1), PPP3CA(3), PPP3CB(1), PTPN7(1), RAC1(1), RAF1(2), RASA1(2), RELA(2), SHC1(1), SOS1(3), VAV1(1), ZAP70(2) 12057104 53 34 53 19 22 4 8 6 13 0 0.883 1.000 1.000 460 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(4), EEF1A2(1), EEF1B2(1), EEF1D(4), EEF1G(2), EEF2(4), EEF2K(5), EIF1AX(1), EIF2AK1(5), EIF2AK2(1), EIF2B5(1), EIF2S3(1), EIF4A1(1), EIF4A2(2), EIF4EBP1(1), EIF4G1(1), EIF4G3(7), EIF5(1), EIF5B(1), GSPT2(2), PABPC1(1), PABPC3(1), PAIP1(1) 11138501 49 34 49 29 16 1 14 6 11 1 0.999 1.000 1.000 461 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(1), ACADL(4), ACADSB(1), ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), AOC2(3), AOC3(2), CNDP1(1), DPYD(4), DPYS(4), EHHADH(2), GAD1(4), GAD2(2), HADHA(3), MLYCD(1), SMS(1) 7332556 48 33 48 18 22 2 8 8 7 1 0.707 1.000 1.000 462 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(1), F12(5), F13B(2), F2(1), F5(3), F7(2), F8(5), FGA(1), FGB(1), LPA(6), PLAT(2), PLAU(1), PLG(2), SERPINB2(1), SERPINE1(1), SERPINF2(1), VWF(7) 8842574 42 33 42 17 20 2 7 7 6 0 0.913 1.000 1.000 463 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(1), CABIN1(6), CAMK1(2), CAMK1G(1), HDAC5(3), IGF1R(4), INS(3), INSR(3), MAPK7(3), MEF2A(2), NFATC1(1), NFATC2(3), PIK3CA(2), PIK3R1(3), PPP3CA(3), PPP3CB(1) 8821872 41 33 40 15 15 7 10 4 5 0 0.778 1.000 1.000 464 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(5), ADC(1), AGMAT(1), ALDH18A1(1), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), AMD1(2), AOC2(3), AOC3(2), ARG1(1), ARG2(1), ASS1(4), CPS1(2), GATM(3), MAOA(2), MAOB(4), NAGS(1), OTC(1), SAT2(1), SMS(1) 7495150 49 33 48 18 21 5 6 8 9 0 0.626 1.000 1.000 465 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(1), ACTR3(1), AKT1(1), DAG1(6), DGKA(1), GCA(1), ITGA9(2), ITPKA(3), ITPKB(3), ITPR1(9), ITPR2(6), ITPR3(4), NR1I3(1), PAK1(1), PDE3B(3), PI3(1), PIK3C2G(6), PIK3CA(2), PIK3CD(1), PIK3R1(3), RPS4X(3) 12387870 59 33 58 24 24 7 11 7 10 0 0.865 1.000 1.000 466 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(1), AKT2(3), AKT3(1), ANKRD6(1), APC(1), AXIN1(5), AXIN2(1), CSNK1A1(1), DACT1(1), DKK3(1), GSK3A(1), GSK3B(2), LRP1(14), MVP(4), NKD1(2), NKD2(4), PIN1(1), PSEN1(2), PTPRA(1), SFRP1(1), WIF1(2) 10268679 50 33 49 21 28 6 7 4 5 0 0.738 1.000 1.000 467 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(3), DIAPH1(5), GSN(2), HRAS(1), ITGA1(3), ITGB1(5), PFN1(1), PIK3CA(2), PIK3R1(3), PTK2(1), PXN(1), RAF1(2), SHC1(1), SRC(2), TLN1(10) 9447590 42 32 42 17 11 6 6 7 12 0 0.956 1.000 1.000 468 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 FCER1A(1), FCER1G(1), FOS(1), HRAS(1), LYN(1), MAP2K7(2), MAP3K1(7), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), PIK3CA(2), PIK3R1(3), PLA2G4A(3), PLCG1(1), PPP3CA(3), PPP3CB(1), RAF1(2), SHC1(1), SOS1(3), SYK(2), VAV1(1) 10821697 47 32 47 20 21 3 8 4 11 0 0.950 1.000 1.000 469 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(1), ALDOB(3), ALDOC(1), GMDS(1), GMPPA(1), GMPPB(2), HK1(1), HK2(2), KHK(3), MTMR2(2), MTMR6(4), PFKFB1(1), PFKFB2(1), PFKFB3(2), PFKFB4(1), PFKL(4), PFKP(3), PHPT1(1), PMM1(1), RDH11(2), RDH13(1), TPI1(3), TSTA3(3) 9505641 44 32 43 26 18 4 7 7 8 0 0.989 1.000 1.000 470 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(6), ACTB(7), ACTG1(1), ARHGEF2(1), CD14(1), CDC42(1), CTTN(2), EZR(1), ITGB1(5), KRT18(1), LY96(1), NCK2(2), RHOA(2), ROCK2(4), TLR4(3), TLR5(3), TUBA4A(2), TUBB(2), TUBB1(1), TUBB2A(1), TUBB8(1), WAS(2) 13186938 50 32 50 19 21 4 8 11 6 0 0.675 1.000 1.000 471 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(6), ACTB(7), ACTG1(1), ARHGEF2(1), CD14(1), CDC42(1), CTTN(2), EZR(1), ITGB1(5), KRT18(1), LY96(1), NCK2(2), RHOA(2), ROCK2(4), TLR4(3), TLR5(3), TUBA4A(2), TUBB(2), TUBB1(1), TUBB2A(1), TUBB8(1), WAS(2) 13186938 50 32 50 19 21 4 8 11 6 0 0.675 1.000 1.000 472 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(1), AKT2(3), AKT3(1), BAD(1), GSK3A(1), GSK3B(2), IL4R(1), IRS1(1), IRS2(2), JAK1(4), JAK3(4), MAP4K1(3), PIK3CA(2), PIK3CD(1), PIK3R1(3), RAF1(2), SHC1(1), SOS1(3), SOS2(3), STAT6(4) 9263506 43 32 43 14 13 2 11 8 9 0 0.597 1.000 1.000 473 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(1), ACTG2(1), ACTR2(1), ACTR3(1), AKT1(1), CDC42(1), CFL2(1), FLNA(9), FLNC(9), FSCN1(1), FSCN2(2), GDI1(1), LIMK1(6), MYH2(1), PAK1(1), PAK3(1), PAK4(2), PAK6(3), PAK7(1), PFN1(1), ROCK2(4), RPS4X(3), WASF1(1) 12180900 53 32 52 27 25 11 11 1 5 0 0.960 1.000 1.000 474 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(1), APC(1), ASAH1(1), CAMP(1), CAV3(1), DAG1(6), DLG4(3), ITPR1(9), ITPR2(6), ITPR3(4), KCNJ3(2), RAC1(1), RYR1(12) 11671975 48 32 48 19 20 5 8 8 7 0 0.707 1.000 1.000 475 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(1), ACAA1(4), ACAA2(1), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), AOX1(1), BCKDHA(1), DBT(2), DLD(3), EHHADH(2), HADHA(3), HADHB(1), HIBADH(1), HIBCH(2), HMGCL(1), HSD17B10(2), HSD17B4(1), IVD(3), MCCC1(3), MCCC2(1), MUT(1), OXCT1(1), PCCA(2), PCCB(1) 10927643 51 31 51 16 24 3 6 12 5 1 0.529 1.000 1.000 476 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(5), CARM1(1), CBS(1), CTH(2), GGT1(2), HEMK1(1), LCMT1(1), MARS(3), MARS2(1), MAT1A(1), MAT2B(1), METTL2B(1), PAPSS2(4), PRMT2(2), PRMT3(1), PRMT5(2), PRMT6(1), PRMT7(3), SCLY(3), SEPHS1(1), SEPHS2(2), WBSCR22(1) 6317303 40 31 40 13 16 3 6 6 9 0 0.577 1.000 1.000 477 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 ABAT(1), ACSM1(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), BDH2(1), EHHADH(2), GAD1(4), GAD2(2), HADHA(3), HMGCL(1), HSD17B10(2), HSD17B4(1), ILVBL(2), L2HGDH(2), OXCT1(1), PLA1A(1), PPME1(1), PRDX6(2), RDH11(2), RDH13(1) 10306880 44 31 44 19 22 2 5 11 4 0 0.867 1.000 1.000 478 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS1(1), ALAS2(2), BLVRB(1), COX10(3), COX15(2), CP(3), EPRS(4), FTMT(1), HMOX1(1), PPOX(1), UGT1A1(1), UGT1A3(1), UGT1A5(2), UGT1A9(2), UGT2A1(4), UGT2A3(1), UGT2B10(1), UGT2B17(1), UGT2B28(1), UGT2B7(2), UROD(1) 10608573 36 31 36 25 14 1 5 13 3 0 0.999 1.000 1.000 479 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(2), BAIAP2(3), CASP1(1), GAPDH(2), INS(3), INSR(3), MAGI1(3), MAGI2(3), RERE(8), WWP1(6), WWP2(3) 6042301 37 31 37 11 16 3 7 5 6 0 0.633 1.000 1.000 480 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(2), CDK5(1), LIMK1(6), MAP3K1(7), PAK1(1), PDGFRA(1), PIK3CA(2), PIK3R1(3), PLD1(2), PPP1R12B(1), RAC1(1), RALBP1(4), TRIO(7), VAV1(1), WASF1(1) 8830984 40 31 40 15 18 1 10 3 8 0 0.817 1.000 1.000 481 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(4), CAMK2B(1), DAG1(6), ITPKA(3), ITPKB(3), ITPR1(9), ITPR2(6), ITPR3(4), NFAT5(3), PDE6A(2), PDE6B(2), PDE6C(1), PDE6D(1), SLC6A13(6) 9110888 51 31 51 20 23 3 8 9 8 0 0.717 1.000 1.000 482 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), ACTN1(1), ACTN2(1), CAPN1(4), ITGA1(3), ITGB1(5), ITGB3(3), PTK2(1), PXN(1), RAC1(1), SPTAN1(6), SRC(2), TLN1(10) 7240903 39 31 39 15 11 6 6 8 8 0 0.800 1.000 1.000 483 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(4), COL4A2(4), COL4A3(6), COL4A4(10), COL4A5(5), COL4A6(6), P4HB(2), SLC23A1(2), SLC23A2(2), SLC2A1(1) 6435052 42 31 42 14 23 3 3 6 6 1 0.943 1.000 1.000 484 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(1), AGT(3), AGTR2(1), COL4A1(4), COL4A2(4), COL4A3(6), COL4A4(10), COL4A5(5), COL4A6(6) 6440800 40 30 40 12 22 3 3 6 5 1 0.889 1.000 1.000 485 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(2), ABAT(1), ADSL(2), ADSS(1), AGXT(2), AGXT2(1), ASNS(2), CAD(5), CRAT(2), DARS(3), DDO(1), GAD1(4), GAD2(2), GOT1(2), GOT2(2), GPT(2), NARS(1), PC(6) 6610283 41 30 41 13 15 3 7 6 10 0 0.572 1.000 1.000 486 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(6), ATR(4), BRCA1(3), BRCA2(7), CHEK1(2), CHEK2(2), FANCA(2), FANCD2(4), FANCG(1), MRE11A(3), RAD50(2), TP53(7), TREX1(1) 11076008 44 30 44 20 17 6 5 12 4 0 0.971 1.000 1.000 487 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(1), CAPN1(4), CAPN2(5), EGF(2), EGFR(2), HRAS(1), ITGA1(3), ITGB1(5), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PTK2(1), PXN(1), TLN1(10) 8331933 40 30 39 13 14 4 6 7 9 0 0.646 1.000 1.000 488 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(1), EIF4A1(1), EIF4A2(2), EIF4B(2), EIF4EBP1(1), EIF4G1(1), EIF4G2(1), EIF4G3(7), PIK3CA(2), PIK3R1(3), PTEN(5), TSC1(3), TSC2(6) 7009055 35 30 35 11 6 1 12 6 10 0 0.703 1.000 1.000 489 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(1), ACACA(5), ACADL(4), ACADSB(1), ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), EHHADH(2), HADHA(3), LDHB(1), MLYCD(1), MUT(1), PCCA(2), PCCB(1), SUCLA2(1), SUCLG2(1) 8350081 39 30 39 13 17 1 7 10 3 1 0.598 1.000 1.000 490 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 AKT1(1), AKT2(3), AKT3(1), BAD(1), CDKN2A(2), DAPP1(2), GSK3A(1), GSK3B(2), IARS(1), IGFBP1(1), INPP5D(1), PIK3CA(2), PTEN(5), RPS6KA1(2), RPS6KA2(3), RPS6KA3(2), SFN(1), SHC1(1), SOS1(3), SOS2(3), YWHAE(1) 9083583 39 30 38 17 12 1 9 9 8 0 0.940 1.000 1.000 491 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(1), BAD(1), CASP1(1), CASP10(2), CASP4(2), CASP9(2), CD40(1), DAXX(2), FADD(1), FASLG(2), IKBKE(3), LTA(1), MCL1(1), NFKB1(3), NFKBIA(2), NR3C1(2), NTRK1(5), PTPN13(7), RIPK1(1), TNF(1), TNFRSF1B(1), TRADD(1), TRAF1(2), TRAF2(1) 11047200 46 29 46 18 15 10 7 6 8 0 0.894 1.000 1.000 492 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(1), BID(2), BIRC3(1), CASP10(2), CASP9(2), CFLAR(1), CHUK(3), FADD(1), GAS2(2), LMNA(3), MAP3K14(2), NFKB1(3), NFKBIA(2), RELA(2), RIPK1(1), SPTAN1(6), TNFRSF10A(1), TNFRSF25(1), TNFSF10(3), TRADD(1), TRAF2(1) 8508673 41 29 41 17 14 4 5 9 9 0 0.886 1.000 1.000 493 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(5), AMD1(2), BHMT(6), CBS(1), CTH(2), DNMT1(9), DNMT3A(7), DNMT3B(2), MARS(3), MARS2(1), MAT1A(1), MAT2B(1), MTR(2) 5261445 42 29 42 13 16 2 10 6 8 0 0.594 1.000 1.000 494 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 ARSB(1), FUCA1(2), FUCA2(1), GBA(1), GLB1(1), GNS(1), HGSNAT(6), HPSE(2), HPSE2(2), HYAL1(2), HYAL2(1), IDUA(5), LCT(5), MAN2B1(2), MAN2B2(2), MANBA(2), NAGLU(4), NEU1(1), NEU2(1), NEU4(2), SPAM1(1) 8852782 45 29 42 19 22 2 8 10 3 0 0.824 1.000 1.000 495 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(2), MRPL13(1), RPL10A(1), RPL11(2), RPL13(1), RPL14(1), RPL18(2), RPL19(1), RPL21(2), RPL23A(1), RPL24(1), RPL26(1), RPL29(1), RPL3(2), RPL3L(1), RPL6(1), RPL9(2), RPS10(1), RPS13(1), RPS15A(1), RPS16(1), RPS2(1), RPS24(2), RPS3A(1), RPS7(1), RPS8(2), RPSA(1) 5672510 35 29 35 17 10 6 5 5 9 0 0.971 1.000 1.000 496 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR2(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(1), C3AR1(2), CCKAR(2), CCKBR(2), CCR1(1), CCR2(1), CCR3(2), CCR5(1), CCR7(2), EDNRB(3), GHSR(1), GNRHR(1), GRPR(1), MC2R(1), MC4R(1), NPY1R(1), NPY2R(1), NTSR1(1), OPRD1(1), OPRL1(1), SSTR1(2), SSTR3(2), SSTR4(2), TACR2(2) 13102458 39 29 39 17 14 6 7 9 3 0 0.715 1.000 1.000 497 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(5), ACYP1(1), AKR1B1(1), ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), DLD(3), LDHB(1), MDH1(1), ME1(1), ME2(1), ME3(3), PC(6), PCK1(1), PKLR(1) 9326720 40 29 40 18 17 2 7 9 4 1 0.905 1.000 1.000 498 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(1), ACTR3(1), ARHGAP1(1), ARHGAP5(3), ARHGAP6(2), ARHGEF1(2), ARHGEF11(5), ARHGEF5(1), ARPC2(1), BAIAP2(3), DIAPH1(5), GSN(2), LIMK1(6), PFN1(1), PIP5K1A(1), PIP5K1B(1), PPP1R12B(1), SRC(2), TLN1(10) 11626616 49 29 49 21 21 7 6 6 9 0 0.896 1.000 1.000 499 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(4), ACAA2(1), ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1), ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), BAAT(2), CEL(3), CYP27A1(2), CYP7A1(2), HADHB(1), SOAT2(1), SRD5A1(1) 5862123 38 28 38 12 21 2 5 6 4 0 0.527 1.000 1.000 500 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 BTG1(1), CBX3(1), CLDN5(1), CLOCK(3), CRY1(1), CRY2(1), EIF4G2(1), ETV6(1), G0S2(1), GFRA1(1), GSTP1(2), HERPUD1(2), HSPA8(2), NCKAP1(2), NCOA4(2), NR1D2(1), PER1(2), PER2(3), PIGF(1), PPP2CB(1), SF3A3(1), TOB1(3), UCP3(1), ZFR(1) 9283297 36 28 36 11 12 1 7 12 4 0 0.597 1.000 1.000 501 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(1), ACO2(3), CS(1), DLD(3), DLST(1), FH(2), IDH1(2), IDH2(4), IDH3B(3), MDH1(1), PC(6), PCK1(1), SDHA(4), SDHB(2), SUCLA2(1), SUCLG2(1) 5204265 36 28 36 12 12 1 6 5 11 1 0.589 1.000 1.000 502 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(5), EGF(2), EGFR(2), FOS(1), HRAS(1), JAK1(4), MAP3K1(7), PIK3CA(2), PIK3R1(3), PLCG1(1), RAF1(2), RASA1(2), SHC1(1), SOS1(3), SRF(1), STAT1(2), STAT3(1), STAT5A(3) 9453367 43 28 43 13 16 0 7 7 13 0 0.675 1.000 1.000 503 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(6), ATM(6), ATR(4), CCNA1(1), CCNE1(2), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(2), GSK3B(2), SKP2(1), TFDP1(1), TGFB1(2), TP53(7) 7614205 37 28 37 14 17 5 4 6 5 0 0.779 1.000 1.000 504 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH3B1(1), ALDH3B2(2), ALDH9A1(1), AOC2(3), AOC3(2), CNDP1(1), DDC(3), HDC(2), HNMT(1), MAOA(2), MAOB(4), PRPS1(1), PRPS2(3) 6180921 40 28 40 13 21 4 8 5 2 0 0.343 1.000 1.000 505 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(1), B4GALT1(1), B4GALT2(1), G6PC2(1), GAA(2), GALE(4), GANC(2), GCK(2), GLA(1), GLB1(1), HK1(1), HK2(2), LCT(5), MGAM(6), PFKL(4), PFKP(3), PGM1(2), PGM3(1), RDH11(2), RDH13(1) 9829079 43 28 43 26 23 3 7 2 8 0 0.992 1.000 1.000 506 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(1), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), AOC2(3), AOC3(2), CNDP1(1), DPYD(4), DPYS(4), EHHADH(2), GAD1(4), GAD2(2), HADHA(3), HIBCH(2), MLYCD(1), SMS(1) 6824485 43 28 43 17 21 2 6 7 7 0 0.744 1.000 1.000 507 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(1), ACACA(5), ACACB(5), ACSS1(3), ACSS2(1), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), EHHADH(2), HADHA(3), HIBCH(2), LDHAL6B(1), LDHB(1), MLYCD(1), MUT(1), PCCA(2), PCCB(1), SUCLA2(1), SUCLG2(1) 10017791 44 28 44 15 24 1 6 9 4 0 0.545 1.000 1.000 508 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 33 GTF2A1(1), GTF2B(3), GTF2I(1), GTF2IRD1(2), STON1(1), TAF1(5), TAF10(1), TAF1L(2), TAF2(1), TAF4(2), TAF4B(4), TAF5(1), TAF5L(3), TAF6(1), TAF7(2), TAF9B(1), TBPL2(1) 9123344 32 28 32 13 10 1 8 9 4 0 0.844 1.000 1.000 509 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(1), AKT2(3), AKT3(1), CISH(2), IARS(1), IL2RG(1), IL4R(1), INPP5D(1), JAK1(4), JAK2(3), JAK3(4), PI3(1), PIK3CA(2), SHC1(1), SOS1(3), SOS2(3), SRC(2), STAT6(4), TYK2(2) 9333504 40 28 39 13 17 5 8 3 7 0 0.608 1.000 1.000 510 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), CHUK(3), FOS(1), IKBKB(3), LY96(1), MAP2K3(2), MAP3K1(7), MAP3K14(2), MAP3K7(1), NFKB1(3), NFKBIA(2), RELA(2), TLR10(2), TLR2(2), TLR3(1), TLR4(3), TLR6(1), TLR7(5), TOLLIP(1) 9216960 43 28 43 17 20 8 3 5 6 1 0.842 1.000 1.000 511 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(1), APAF1(1), ATM(6), BAD(1), BID(2), CASP9(2), PTK2(1), PXN(1), STAT1(2), TLN1(10), TP53(7) 6915074 34 27 34 15 10 4 5 10 5 0 0.917 1.000 1.000 512 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(1), AKT1(1), ASAH1(1), GNB1(2), ITGAV(2), ITGB3(3), PDGFA(1), PDGFRA(1), PIK3CA(2), PIK3R1(3), PLCB1(2), PTK2(1), RAC1(1), SMPD1(3), SMPD2(2), SPHK1(2), SRC(2) 6902983 30 27 30 12 9 3 11 4 3 0 0.885 1.000 1.000 513 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(2), ARSB(1), ARSD(2), ARSE(3), ASAH1(1), GAL3ST1(1), GALC(3), GBA(1), GLA(1), GLB1(1), LCT(5), NEU1(1), NEU2(1), NEU4(2), PPAP2C(1), SMPD1(3), SMPD2(2), SPTLC2(2) 6126713 33 27 33 11 12 3 7 4 7 0 0.711 1.000 1.000 514 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 B3GNT1(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), B4GALT6(1), FUT2(2), FUT4(2), FUT6(1), FUT7(1), GBGT1(1), PIGB(2), PIGF(1), PIGK(2), PIGL(1), PIGN(3), PIGO(2), PIGQ(3), PIGS(1), PIGU(1), PIGX(1), ST3GAL3(2), ST3GAL4(3), ST6GALNAC4(1), ST6GALNAC5(2), ST6GALNAC6(2), ST8SIA5(2) 12350622 41 27 41 17 22 2 7 5 5 0 0.691 1.000 1.000 515 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(1), BAD(1), CBL(2), CFLAR(1), CRKL(1), FOS(1), HRAS(1), IL2RA(1), IL2RB(3), IL2RG(1), IRS1(1), JAK1(4), JAK3(4), NMI(1), PIK3CA(2), PIK3R1(3), PPIA(1), RAF1(2), SHC1(1), SOS1(3), STAT5A(3), STAT5B(2), SYK(2) 9162117 42 27 42 13 18 1 8 5 10 0 0.546 1.000 1.000 516 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(5), FOS(1), HRAS(1), JAK1(4), MAP3K1(7), PDGFA(1), PDGFRA(1), PIK3CA(2), PIK3R1(3), PLCG1(1), RAF1(2), RASA1(2), SHC1(1), SOS1(3), SRF(1), STAT1(2), STAT3(1), STAT5A(3) 8814454 41 27 41 13 15 0 8 6 12 0 0.716 1.000 1.000 517 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 FADD(1), LMNA(3), LMNB2(1), MADD(6), MAP3K1(7), MAP3K7(1), PAK1(1), PRKDC(4), RIPK1(1), SPTAN1(6), TNF(1), TRADD(1), TRAF2(1) 9920473 34 27 34 25 14 2 3 5 9 1 1.000 1.000 1.000 518 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(3), EIF2B5(1), EIF2S3(1), ELAVL1(1), FLT1(2), FLT4(5), HIF1A(2), HRAS(1), KDR(4), NOS3(3), PIK3CA(2), PIK3R1(3), PLCG1(1), PTK2(1), PXN(1), SHC1(1), VHL(2) 8664677 34 27 34 16 10 1 8 4 10 1 0.965 1.000 1.000 519 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(3), APC(1), ATF2(1), AXIN1(5), BMP10(1), BMP4(1), BMP7(1), BMPR1A(1), CHRD(3), FZD1(2), GSK3B(2), MAP3K7(1), NKX2-5(4), NOG(1), RFC1(2), TGFB1(2), TGFBR1(1), TGFBR2(1) 9207882 33 26 33 19 14 3 7 2 6 1 0.971 1.000 1.000 520 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(6), ATM(6), BRCA1(3), CDKN1A(1), CHEK1(2), CHEK2(2), MDM2(1), MRE11A(3), NFKB1(3), NFKBIA(2), RAD50(2), RBBP8(4), RELA(2), TP53(7) 7489594 44 26 44 18 19 4 7 8 6 0 0.914 1.000 1.000 521 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(3), AGTR2(1), CAMK2A(4), CAMK2B(1), CDK5(1), F2(1), GNA11(1), GNB1(2), HRAS(1), JAK2(3), MAP2K2(1), PLCG1(1), PTK2B(1), RAF1(2), SHC1(1), SOS1(3), STAT1(2), STAT3(1), STAT5A(3) 10603309 33 26 33 17 11 3 6 6 7 0 0.965 1.000 1.000 522 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 DPM2(1), EGFR(2), GNAS(3), GNB1(2), HRAS(1), IGF1R(4), ITGB1(5), KLK2(1), MAP2K2(1), PDGFRA(1), PTPRR(3), RAF1(2), RPS6KA1(2), SHC1(1), SOS1(3), SRC(2), STAT3(1) 8426231 35 26 35 15 13 5 4 5 8 0 0.881 1.000 1.000 523 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(3), ADRBK2(3), ARRB2(2), CAMK2A(4), CAMK2B(1), CLCA1(3), CLCA2(2), CLCA4(1), CNGA3(2), CNGA4(2), CNGB1(5), GUCA1B(1), PDE1C(1), PRKACA(2), PRKACB(1), PRKACG(1), PRKG1(1), PRKG2(3), PRKX(3) 7751811 41 26 40 20 21 4 10 1 5 0 0.919 1.000 1.000 524 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1), ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), AOC2(3), AOC3(2), AOX1(1), DBH(1), DCT(2), DDC(3), GOT1(2), GOT2(2), HGD(1), HPD(3), MAOA(2), MAOB(4), PNMT(1), TPO(1) 8031512 38 26 38 19 20 5 7 3 3 0 0.899 1.000 1.000 525 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(1), FOS(1), HRAS(1), LYN(1), MAP3K1(7), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), PLCG1(1), PPP3CA(3), PPP3CB(1), RAC1(1), RAF1(2), SHC1(1), SOS1(3), SYK(2), VAV1(1) 9622949 37 25 37 16 19 2 4 3 9 0 0.926 1.000 1.000 526 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(1), B4GALT1(1), B4GALT2(1), GAA(2), GALE(4), GCK(2), GLA(1), GLB1(1), HK1(1), HK2(2), LCT(5), MGAM(6), PFKP(3), PGM1(2), PGM3(1) 8287226 33 25 33 23 16 3 6 1 7 0 0.998 1.000 1.000 527 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(3), ALDOC(1), G6PD(1), H6PD(2), PFKL(4), PFKP(3), PGM1(2), PGM3(1), PRPS1(1), PRPS2(3), RBKS(1), RPE(2), RPIA(1), TKT(2), TKTL2(1) 6154261 28 25 28 11 12 1 7 2 6 0 0.713 1.000 1.000 528 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), AOC2(3), AOC3(2), DDC(3), EPX(3), ESCO2(1), GOT1(2), GOT2(2), HPD(3), MAOA(2), MAOB(4), MPO(3), PNPLA3(1), PRDX6(2), TPO(1) 8635537 36 25 36 12 15 4 8 5 4 0 0.495 1.000 1.000 529 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT3(2), AGPAT6(1), AGPS(7), CHPT1(1), ENPP6(1), PAFAH1B2(2), PAFAH2(2), PLA2G12A(2), PLA2G2D(3), PLA2G3(1), PLA2G4A(3), PLA2G6(3), PLD1(2), PLD2(1), PPAP2C(1) 5899293 33 25 33 12 18 2 6 2 5 0 0.609 1.000 1.000 530 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(1), ACTG2(1), ADCY3(3), ADCY9(7), ARF3(2), ARF5(1), ATP6V0A1(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0B(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1H(1), GNAS(3), PDIA4(1), PLCG1(1), PLCG2(4), SEC61B(2), TRIM23(2) 9386648 39 25 39 19 16 4 9 5 5 0 0.919 1.000 1.000 531 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), AOC2(3), AOC3(2), DDC(3), EPX(3), GOT1(2), GOT2(2), HPD(3), MAOA(2), MAOB(4), MPO(3), PRDX2(1), PRDX6(2), TPO(1) 5584755 35 25 35 12 14 4 7 6 4 0 0.452 1.000 1.000 532 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(3), GTF2A1(1), GTF2B(3), NCOA1(1), NCOA2(8), NCOA3(6), NCOR2(8), POLR2A(4), RXRA(2) 6365182 36 25 35 19 21 2 7 4 2 0 0.942 1.000 1.000 533 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 37 CCNH(1), ERCC3(3), GTF2B(3), POLR1A(1), POLR1B(2), POLR2A(4), POLR2B(4), POLR2F(1), POLR2I(1), POLR2J(1), POLR3B(3), POLR3E(1), TAF5(1), TAF6(1), TAF7(2) 8884932 29 25 29 16 10 2 9 4 4 0 0.983 1.000 1.000 534 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 GORASP1(1), MAP2K7(2), MAPK10(2), MAPK12(2), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(4), MAPK9(2), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIL1(1), PIK3CA(2), PIK3CD(1), PIK3R1(3), TRAF2(1), TRAF5(2) 8635958 35 25 34 16 13 3 8 4 7 0 0.902 1.000 1.000 535 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(1), AXIN1(5), BTRC(1), CREBBP(5), CSNK1A1(1), CSNK1D(1), CSNK2A1(5), CTBP1(3), FZD1(2), GSK3B(2), MAP3K7(1), NLK(2), PPARD(1), TLE1(2), WIF1(2) 7481270 34 25 34 12 19 1 5 3 5 1 0.680 1.000 1.000 536 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP10(2), CFLAR(1), DAXX(2), FADD(1), LMNA(3), LMNB2(1), MAP3K1(7), MAP3K7(1), PAK1(1), PRKDC(4), PTPN13(7), RIPK2(4), SPTAN1(6) 10475175 40 24 40 24 18 4 4 3 10 1 0.998 1.000 1.000 537 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(1), APC(1), AXIN1(5), CD14(1), FZD1(2), GSK3B(2), LBP(1), LEF1(2), LY96(1), NFKB1(3), PIK3CA(2), PIK3R1(3), RELA(2), TLR4(3), TOLLIP(1) 7760317 30 24 30 14 15 2 5 4 4 0 0.893 1.000 1.000 538 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(3), IKBKB(3), IL1B(1), IL1R1(1), IL1RN(1), MAP2K3(2), MAP3K1(7), MAP3K14(2), MAP3K7(1), NFKB1(3), NFKBIA(2), RELA(2), TGFB1(2), TNF(1), TOLLIP(1) 7505198 32 24 32 13 13 3 5 3 7 1 0.861 1.000 1.000 539 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BAD(1), BRAF(2), CREB3(3), DUSP4(3), DUSP6(3), EEF2K(5), MAP2K2(1), MAP3K8(1), NFKB1(3), RPS6KA1(2), RPS6KA2(3), RPS6KA3(2), SHC1(1), SOS1(3), SOS2(3) 7505606 36 24 35 11 14 2 5 9 6 0 0.550 1.000 1.000 540 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(3), ATF2(1), EGFR(2), HRAS(1), MAP2K2(1), MAP3K1(7), MEF2A(2), PAK1(1), PTK2(1), PTK2B(1), RAC1(1), RAF1(2), SHC1(1), SOS1(3), SRC(2) 8514774 29 23 29 10 12 2 4 4 7 0 0.740 1.000 1.000 541 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 ABAT(1), ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), EHHADH(2), GAD1(4), GAD2(2), HADHA(3), HMGCL(1), L2HGDH(2), OXCT1(1), SDHB(2) 6523592 33 23 33 14 18 1 4 7 3 0 0.800 1.000 1.000 542 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(1), CSF1R(2), DDX20(4), ETS1(1), FOS(1), HDAC5(3), HRAS(1), NCOR2(8), RBL1(2), RBL2(4), SIN3A(5), SIN3B(5) 6728713 37 23 36 14 18 3 6 4 6 0 0.683 1.000 1.000 543 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(1), FOS(1), GNAS(3), GNB1(2), HRAS(1), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), PLCG1(1), PPP3CA(3), PPP3CB(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), RAF1(2), RPS6KA3(2) 8829031 33 23 33 16 15 2 4 5 7 0 0.976 1.000 1.000 544 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(3), C5(1), C6(2), C7(2), ICAM1(1), ITGA4(2), ITGAL(3), ITGB1(5), ITGB2(3), SELP(2), SELPLG(1), TNF(1), VCAM1(2) 6235160 28 23 28 10 10 2 6 6 4 0 0.699 1.000 1.000 545 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(6), BMPR1B(1), CDK4(1), DAZL(1), ESR2(2), MLH1(4), MSH5(1), NCOR1(4), PGR(2), PRLR(1), SMPD1(3), VDR(1), ZP2(4) 8804766 31 23 31 19 14 1 10 3 3 0 0.988 1.000 1.000 546 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CHUK(3), MAP3K1(7), NFATC1(1), NFATC2(3), NFKB1(3), NFKBIA(2), PLCG1(1), PPP3CA(3), PPP3CB(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), RELA(2), VIP(1), VIPR2(1) 7031527 33 23 33 14 15 1 4 3 10 0 0.928 1.000 1.000 547 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(1), BAD(1), CHRNB1(3), CHRNG(1), MUSK(1), PIK3CA(2), PIK3R1(3), PTK2(1), PTK2B(1), RAPSN(1), SRC(2), TERT(8) 4171660 25 22 25 11 10 2 5 5 3 0 0.829 1.000 1.000 548 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(1), EIF4A1(1), EIF4A2(2), EIF4EBP1(1), EIF4G1(1), EIF4G2(1), EIF4G3(7), IRS1(1), PABPC1(1), PIK3CA(2), PIK3R1(3), PTEN(5) 7091018 26 22 26 11 4 0 8 5 9 0 0.913 1.000 1.000 549 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(1), ALDOB(3), ALDOC(1), GCK(2), GMDS(1), GMPPA(1), GMPPB(2), HK1(1), HK2(2), KHK(3), PFKFB1(1), PFKFB3(2), PFKFB4(1), PFKP(3), PMM1(1), TPI1(3) 6093093 28 22 28 18 9 4 4 5 6 0 0.988 1.000 1.000 550 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG10B(1), ALG12(1), ALG2(2), ALG3(1), ALG5(1), ALG6(3), ALG9(2), B4GALT1(1), B4GALT2(1), B4GALT3(1), DDOST(1), DPAGT1(2), MAN1B1(1), MAN1C1(3), MAN2A1(1), MGAT1(1), MGAT2(1), MGAT3(1), MGAT4B(1), MGAT5(1), MGAT5B(3), RFT1(3), RPN1(1), RPN2(1), ST6GAL1(1) 10758442 36 22 36 12 19 2 5 2 8 0 0.621 1.000 1.000 551 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(2), AP2A1(2), AP2M1(2), BIN1(3), DNM1(3), EPS15(3), NME1(1), PICALM(2), PPP3CA(3), PPP3CB(1), SYNJ1(4), SYNJ2(2) 5567873 28 22 28 11 12 3 2 7 4 0 0.844 1.000 1.000 552 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(3), ALDOC(1), G6PD(1), H6PD(2), PFKP(3), PGM1(2), PGM3(1), PRPS1(1), PRPS2(3), RBKS(1), RPE(2), RPIA(1), TAL1(3), TKT(2) 5139463 26 22 26 10 11 1 7 2 5 0 0.700 1.000 1.000 553 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(5), EP300(11), LPL(1), NCOA1(1), NCOA2(8), RXRA(2) 4642185 28 22 28 12 13 1 6 3 5 0 0.933 1.000 1.000 554 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(1), BCR(3), BLNK(1), FOS(1), HRAS(1), LYN(1), MAP3K1(7), MAPK8IP3(4), PAPPA(4), RAC1(1), RPS6KA1(2), RPS6KA3(2), SHC1(1), SOS1(3), SYK(2), VAV1(1), VAV2(1), VAV3(5) 8131165 41 22 39 20 19 3 5 3 11 0 0.968 1.000 1.000 555 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(1), ASAH1(1), CAMP(1), CERK(1), CREB3(3), DAG1(6), FOS(1), ITPKA(3), ITPKB(3), MAP2K7(2), MAPK10(2), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(4), MAPK9(2) 7236392 34 22 33 16 15 3 3 5 8 0 0.931 1.000 1.000 556 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(2), GNB1(2), HRAS(1), NFKB1(3), PIK3C2G(6), PIK3CA(2), PIK3R1(3), PLCG1(1), PTK2(1), PTK2B(1), PXN(1), RAF1(2), RELA(2) 7065057 27 21 27 11 9 1 6 4 7 0 0.902 1.000 1.000 557 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 HRAS(1), INS(3), INSR(3), IRS1(1), JAK2(3), PIK3CA(2), PIK3R1(3), PLCG1(1), RAF1(2), RPS6KA1(2), SHC1(1), SLC2A4(1), SOS1(3), SRF(1), STAT5A(3), STAT5B(2) 8360360 32 21 32 13 13 4 6 3 6 0 0.903 1.000 1.000 558 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(1), BCR(3), CRKL(1), FOS(1), HRAS(1), JAK2(3), MAP3K1(7), PIK3CA(2), PIK3R1(3), RAF1(2), SOS1(3), STAT1(2), STAT5A(3), STAT5B(2) 7052910 34 21 34 16 13 2 6 3 10 0 0.968 1.000 1.000 559 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(1), GLB1(1), GNS(1), HGSNAT(6), HPSE(2), HPSE2(2), HYAL1(2), HYAL2(1), IDUA(5), LCT(5), NAGLU(4), SPAM1(1) 5250513 31 21 28 12 15 0 5 8 3 0 0.749 1.000 1.000 560 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX15(2), ALOX5(3), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP3A4(2), CYP3A43(2), CYP3A7(1), PLA2G12A(2), PLA2G2D(3), PLA2G3(1), PLA2G4A(3), PLA2G6(3), RDH11(2), RDH13(1) 6057940 28 21 28 10 15 3 3 2 5 0 0.653 1.000 1.000 561 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(1), EIF2B5(1), EIF2S3(1), EIF4EBP1(1), GSK3B(2), IGF1R(4), INPPL1(3), PIK3CA(2), PIK3R1(3), PTEN(5) 4994725 23 21 23 12 6 2 7 3 5 0 0.978 1.000 1.000 562 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(1), ADCY1(1), CAP1(2), CCNB1(1), CDC25C(1), GNAS(3), GNB1(2), HRAS(1), MYT1(7), PIN1(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), RPS6KA1(2), SRC(2) 5231907 29 21 29 16 14 3 4 5 3 0 0.978 1.000 1.000 563 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(2), CRKL(1), HRAS(1), MAP2K2(1), MAP2K3(2), MAP3K1(7), PAK1(1), PLCG1(1), PTK2B(1), RAC1(1), RAF1(2), SHC1(1), SOS1(3), SRC(2) 7221511 26 21 26 11 9 3 5 2 7 0 0.905 1.000 1.000 564 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BIRC3(1), CFLAR(1), FADD(1), MAP3K7(1), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIL1(1), NR2C2(3), RALBP1(4), RIPK1(1), TNF(1), TNFAIP3(2), TNFRSF1B(1), TRADD(1), TRAF2(1) 6936541 27 21 26 13 6 4 8 2 6 1 0.928 1.000 1.000 565 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CHUK(3), IKBKB(3), LTA(1), MAP2K3(2), MAP3K1(7), MAP3K14(2), MAP4K2(1), NFKB1(3), NFKBIA(2), RELA(2), RIPK1(1), TNF(1), TRADD(1), TRAF2(1) 6149550 30 21 30 12 13 4 3 3 7 0 0.865 1.000 1.000 566 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(1), CREBBP(5), EP300(11), NCOA3(6), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), RXRA(2) 5224299 30 20 30 11 15 2 3 3 7 0 0.846 1.000 1.000 567 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(1), MAP2K2(1), MAP2K3(2), MAP3K1(7), NFKB1(3), PIK3CA(2), PIK3R1(3), RELA(2) 4916307 21 20 21 11 7 3 4 2 5 0 0.975 1.000 1.000 568 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(1), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), CYP2C19(1), CYP2C9(1), DHRS1(1), DHRS2(1), EHHADH(2), ESCO2(1), HADHA(3), PNPLA3(1), YOD1(1) 7790327 26 20 26 11 13 1 4 6 2 0 0.833 1.000 1.000 569 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 DLG4(3), GRIN2A(2), GRIN2B(5), GRIN2C(1), GRIN2D(3), NOS1(4), PPP3CA(3), PPP3CB(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1) 6515236 27 20 27 13 16 0 3 4 4 0 0.900 1.000 1.000 570 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(1), AP2A1(2), AP2M1(2), BAD(1), EEA1(2), GSK3A(1), GSK3B(2), LYN(1), PFKL(4), PFKP(3), PLCG1(1), PRKCE(2), RAC1(1), VAV2(1) 6286022 24 20 24 19 9 2 6 5 2 0 0.999 1.000 1.000 571 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(1), FADD(1), MAP3K1(7), NFKB1(3), NSMAF(4), RAF1(2), RELA(2), RIPK1(1), SMPD1(3), TRADD(1), TRAF2(1) 5186412 26 19 26 11 9 4 4 2 7 0 0.926 1.000 1.000 572 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(1), AKT1(1), CAMK2A(4), CAMK2B(1), GNAS(3), HRAS(1), PIK3CA(2), PIK3R1(3), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), RAC1(1), RPS6KA1(2), SOS1(3) 7395197 27 19 27 22 9 2 7 3 6 0 1.000 1.000 1.000 573 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(1), KHK(3), LCT(5), PGM1(2), PYGL(2), PYGM(4), TPI1(3), TREH(2) 3412171 22 19 22 12 11 2 4 4 1 0 0.899 1.000 1.000 574 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(1), DCXR(2), RPE(2), UGDH(1), UGT1A1(1), UGT1A3(1), UGT1A5(2), UGT1A9(2), UGT2A1(4), UGT2A3(1), UGT2B10(1), UGT2B17(1), UGT2B28(1), UGT2B7(2), XYLB(1) 6829202 23 19 23 10 10 2 1 8 2 0 0.900 1.000 1.000 575 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(3), ADRA1B(1), ADRA2C(1), CHRM1(2), CHRM2(3), CHRM3(2), DRD4(2), DRD5(3), HRH2(1), HTR1B(1), HTR2A(1), HTR2B(1), HTR4(1), HTR6(1), HTR7(1) 6507134 24 19 24 10 13 2 7 2 0 0 0.470 1.000 1.000 576 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 ICAM1(1), ITGA4(2), ITGAL(3), ITGAM(4), ITGB1(5), ITGB2(3), SELE(1), SELL(2), SELP(2) 4057562 23 19 23 10 8 3 5 3 4 0 0.856 1.000 1.000 577 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(1), CDC42(1), DAXX(2), HRAS(1), MAP3K1(7), MAP3K5(1), MAP3K7(1), MAP3K9(5), MAX(1), MEF2A(2), PLA2G4A(3), RAC1(1), RIPK1(1), SHC1(1), STAT1(2), TGFB1(2), TGFBR1(1), TRADD(1), TRAF2(1) 9316831 35 19 35 19 21 1 4 2 6 1 0.969 1.000 1.000 578 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(1), CDC42(1), CREB3(3), EEF2K(5), IL1R1(1), MAP2K3(2), MAP3K10(1), MAP3K4(1), MAP3K5(1), MAP3K7(1), MAPK12(2), MYEF2(1), NFKB1(3), NR2C2(3), SRF(1) 8497615 27 19 26 16 13 4 5 1 3 1 0.974 1.000 1.000 579 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(1), AKT1(1), BAD(1), CSF2RB(2), IGF1R(4), KIT(1), PIK3CA(2), PIK3R1(3), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1) 5529329 20 18 20 16 7 3 3 3 4 0 0.999 1.000 1.000 580 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(5), CD2(1), CD5(1), CD7(1), IL10(1), ITGAX(5), TLR2(2), TLR4(3), TLR7(5) 4690258 24 18 24 10 13 3 4 2 2 0 0.582 1.000 1.000 581 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT2(2), EXTL1(1), GLCE(2), HS2ST1(2), HS3ST2(1), HS3ST3A1(1), HS6ST2(3), HS6ST3(1), NDST1(3), NDST2(1), NDST3(2), NDST4(2) 5278458 21 18 21 12 9 4 3 3 2 0 0.944 1.000 1.000 582 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CD3G(1), CD4(2), CREBBP(5), CSK(1), GNAS(3), GNB1(2), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PTPRC(2), ZAP70(2) 5826711 24 17 24 12 10 2 3 3 6 0 0.962 1.000 1.000 583 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CD3G(1), CD4(2), CREBBP(5), CSK(1), GNAS(3), GNB1(2), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PTPRC(2), ZAP70(2) 5826711 24 17 24 12 10 2 3 3 6 0 0.962 1.000 1.000 584 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 FUCA1(2), FUCA2(1), GLB1(1), LCT(5), MAN2B1(2), MAN2B2(2), MANBA(2), NEU1(1), NEU2(1), NEU4(2) 5203640 19 17 19 10 10 2 5 1 1 0 0.900 1.000 1.000 585 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(5), DPM2(1), FOS(1), HRAS(1), KLK2(1), PIK3CA(2), PIK3R1(3), PLCG1(1), RAF1(2), SHC1(1), SOS1(3) 4817336 21 17 21 11 7 0 5 3 6 0 0.955 1.000 1.000 586 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRB(1), CP(3), EPRS(4), HMOX1(1), PPOX(1), UGT1A1(1), UGT1A3(1), UGT1A5(2), UGT1A9(2), UROD(1) 6897760 17 17 17 13 7 1 2 6 1 0 0.995 1.000 1.000 587 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(1), HRAS(1), MAPK7(3), MEF2A(2), NTRK1(5), PIK3CA(2), PIK3R1(3), PLCG1(1), RPS6KA1(2), SHC1(1) 4862805 21 16 20 15 6 5 7 2 1 0 0.995 1.000 1.000 588 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1) 3358679 19 16 19 9 10 2 2 5 0 0 0.834 1.000 1.000 589 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), MIOX(1), UGDH(1) 2164287 15 14 15 6 7 1 2 5 0 0 0.692 1.000 1.000 590 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(1), DHRS1(1), DHRS2(1), HEMK1(1), LCMT1(1), METTL2B(1), PRMT2(2), PRMT3(1), PRMT5(2), PRMT6(1), PRMT7(3), WBSCR22(1) 3796786 16 14 16 10 8 2 0 1 5 0 0.953 1.000 1.000 591 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(3), GABRA3(2), GABRA4(1), GPHN(7), SRC(2) 3012148 15 13 15 7 8 1 4 2 0 0 0.816 1.000 1.000 592 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(1), AKT2(3), AKT3(1), CDKN1A(1), HRAS(1), MAP2K2(1), NTRK1(5), PIK3CA(2), PIK3CD(1), SHC1(1), SOS1(3) 4127604 20 13 20 11 6 3 7 2 2 0 0.914 1.000 1.000 593 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(2), GLI2(1), GLI3(3), GSK3B(2), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), SHH(1), SUFU(3) 4204187 17 13 17 10 8 2 2 2 3 0 0.957 1.000 1.000 594 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(1), DPM2(1), HRAS(1), KLK2(1), NTRK1(5), PIK3CA(2), PIK3R1(3), PLCG1(1), SHC1(1), SOS1(3) 3928785 19 13 19 13 7 2 6 1 3 0 0.991 1.000 1.000 595 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QB(1), C1R(2), C1S(1), C2(2), C3(3), C5(1), C6(2), C7(2), C8A(1), MASP1(1) 5272046 16 12 16 6 9 2 2 3 0 0 0.701 1.000 1.000 596 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL4(1), CCR1(1), CCR2(1), CCR3(2), CCR5(1), CCR7(2), CD4(2), IFNGR1(1), IL12RB1(3), IL12RB2(1), IL4R(1), TGFB1(2) 5065355 18 12 18 11 8 3 0 3 4 0 0.967 1.000 1.000 597 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(1), CSNK1D(1), PLCB1(2), PPP1CA(2), PPP3CA(3), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1) 4045074 14 11 14 10 7 1 0 3 3 0 0.987 1.000 1.000 598 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(2), ACAD9(2), ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1), DHRS1(1), DHRS2(1), ESCO2(1), PNPLA3(1) 6269192 14 11 14 9 8 1 3 2 0 0 0.962 1.000 1.000 599 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(1), GNAS(3), GNB1(2), PRKAB1(1), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAG2(3), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1) 3902015 16 10 16 10 8 1 2 2 3 0 0.980 1.000 1.000 600 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(3), HK1(1), PFKL(4), PKLR(1), TPI1(3) 2340565 12 10 12 11 5 1 2 1 3 0 0.984 1.000 1.000 601 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 GPR161(2), GPR18(2), GPR39(2), GPR65(2), GPR68(1) 2472067 9 8 9 5 4 1 4 0 0 0 0.761 1.000 1.000 602 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(2), HK1(1), HK2(2), PGM1(2), PGM3(1) 2974491 8 8 8 6 4 2 2 0 0 0 0.917 1.000 1.000 603 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(2), HK1(1), HK2(2), PGM1(2), PGM3(1) 2607302 8 8 8 6 4 2 2 0 0 0 0.925 1.000 1.000 604 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(1), GNAS(3), GNB1(2), PRKACA(2) 1680489 8 7 8 4 4 1 1 2 0 0 0.904 1.000 1.000 605 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ATF3(1), CYR61(1), EIF4EBP1(1), HBEGF(1), IL1R1(1), MYOG(1), WDR1(2) 2739783 8 7 8 6 4 1 2 1 0 0 0.958 1.000 1.000 606 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(1), CAPN1(4), CDK5(1), CSNK1A1(1), CSNK1D(1), GSK3B(2) 2396777 10 7 10 9 8 1 0 1 0 0 0.983 1.000 1.000 607 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1) 1410805 6 6 6 3 4 1 0 1 0 0 0.868 1.000 1.000 608 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(3), AOC3(2), CES1(1), ESD(1) 1516732 7 6 7 6 3 0 2 2 0 0 0.954 1.000 1.000 609 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA3(2), GABRA4(1), GPX1(1), PRKCE(2) 1886637 6 6 6 7 2 0 4 0 0 0 0.992 1.000 1.000 610 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(1), FOS(1), THBS1(5) 1844317 7 6 7 10 1 0 0 3 3 0 1.000 1.000 1.000 611 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 EPHX2(2), RDH11(2), RDH13(1) 1211630 5 4 5 3 4 0 0 1 0 0 0.845 1.000 1.000 612 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(1), FDPS(1), IDI2(1), SQLE(1) 1086143 4 4 4 3 1 1 2 0 0 0 0.948 1.000 1.000 613 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(1), DHRS2(1), ESCO2(1), PNPLA3(1) 4147712 4 3 4 4 3 0 1 0 0 0 0.968 1.000 1.000 614 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(1), FDPS(1), SQLE(1) 816578 3 3 3 3 1 1 1 0 0 0 0.973 1.000 1.000 615 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 182034 0 0 0 2 0 0 0 0 0 0 1.000 1.000 1.000 616 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 383227 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000