E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.009 0.165 -9999.0 0.0 -0.568 17.0 17.0 KLHL20 -0.014 0.049 -9999.0 0.0 -0.35 1.0 1.0 CYFIP2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.025 0.109 -9999.0 0.0 -0.344 17.0 17.0 ENAH -0.009 0.165 -9999.0 0.0 -0.568 17.0 17.0 AP1M1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.023 0.077 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.009 0.033 -9999.0 0.0 -0.225 1.0 1.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.01 0.141 -9999.0 0.0 -0.489 17.0 17.0 RAPGEF1 0.007 0.143 -9999.0 0.0 -0.478 17.0 17.0 CTNND1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.047 0.16 -9999.0 0.0 -0.591 17.0 17.0 CRK -0.001 0.155 -9999.0 0.0 -0.526 17.0 17.0 E-cadherin/gamma catenin/alpha catenin -0.043 0.145 -9999.0 0.0 -0.536 17.0 17.0 alphaE/beta7 Integrin 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.009 0.165 -9999.0 0.0 -0.568 17.0 17.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.017 0.056 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.022 0.018 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.021 0.072 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.033 0.173 -9999.0 0.0 -0.62 17.0 17.0 TIAM1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ -0.037 0.126 -9999.0 0.0 -0.464 17.0 17.0 AKT1 -0.012 0.04 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.053 0.223 -9999.0 0.0 -0.809 17.0 17.0 RhoA/GDP 0.024 0.109 -9999.0 0.0 -0.344 16.0 16.0 actin cytoskeleton organization 0.029 0.048 -9999.0 0.0 -0.245 1.0 1.0 CDC42/GDP 0.024 0.109 -9999.0 0.0 -0.344 17.0 17.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.006 0.098 -9999.0 0.0 -0.339 17.0 17.0 ITGB7 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.01 0.141 -9999.0 0.0 -0.489 17.0 17.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.038 0.128 -9999.0 0.0 -0.471 17.0 17.0 mol:GDP 0.017 0.126 -9999.0 0.0 -0.408 17.0 17.0 CDC42/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.028 0.095 -9999.0 0.0 -0.351 16.0 16.0 RAC1/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.024 0.037 -9999.0 0.0 -0.293 1.0 1.0 NME1 0.008 0.035 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.009 0.165 -9999.0 0.0 -0.568 17.0 17.0 regulation of cell-cell adhesion -0.02 0.068 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.005 0.017 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.026 0.089 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.036 0.124 -9999.0 0.0 -0.457 17.0 17.0 CCND1 0.027 0.045 -9999.0 0.0 -0.376 1.0 1.0 VAV2 0.005 0.15 -9999.0 0.0 -0.504 17.0 17.0 RAP1/GDP 0.021 0.104 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.008 0.159 -9999.0 0.0 -0.547 17.0 17.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.004 0.129 -9999.0 0.0 -0.434 17.0 17.0 E-cadherin/beta catenin -0.039 0.134 -9999.0 0.0 -0.494 17.0 17.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.009 0.165 -9999.0 0.0 -0.568 17.0 17.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.023 0.082 -9999.0 0.0 -0.654 1.0 1.0 E-cadherin/beta catenin/alpha catenin -0.043 0.145 -9999.0 0.0 -0.536 17.0 17.0 ITGAE 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.048 0.164 -9999.0 0.0 -0.607 17.0 17.0