Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.007 0.158 -9999.0 0.0 -0.593 2.0 2.0 IHH -0.081 0.274 -9999.0 0.0 -0.827 25.0 25.0 SHH Np/Cholesterol/GAS1 -0.012 0.128 -9999.0 0.0 -0.505 13.0 13.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.012 0.127 0.501 13.0 -9999.0 0.0 13.0 SMO/beta Arrestin2 -0.012 0.177 -9999.0 0.0 -0.573 6.0 6.0 SMO -0.018 0.186 -9999.0 0.0 -0.503 26.0 26.0 AKT1 0.015 0.085 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.011 0.02 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.017 0.183 -9999.0 0.0 -0.496 26.0 26.0 STIL -0.008 0.148 -9999.0 0.0 -0.443 10.0 10.0 DHH N/PTCH2 -0.009 0.122 -9999.0 0.0 -0.62 8.0 8.0 DHH N/PTCH1 -0.033 0.183 -9999.0 0.0 -0.456 32.0 32.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.02 0.156 -9999.0 0.0 -0.809 8.0 8.0 PTHLH -0.016 0.185 -9999.0 0.0 -0.762 2.0 2.0 determination of left/right symmetry -0.017 0.183 -9999.0 0.0 -0.496 26.0 26.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.016 0.184 -9999.0 0.0 -0.754 2.0 2.0 IHH N/Hhip -0.077 0.223 -9999.0 0.0 -0.582 34.0 34.0 DHH N/Hhip -0.036 0.187 -9999.0 0.0 -0.688 15.0 15.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.017 0.183 -9999.0 0.0 -0.496 26.0 26.0 pancreas development -0.027 0.167 -9999.0 0.0 -0.676 12.0 12.0 HHAT 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.026 0.174 -9999.0 0.0 -0.809 10.0 10.0 somite specification -0.017 0.183 -9999.0 0.0 -0.496 26.0 26.0 SHH Np/Cholesterol/PTCH1 -0.013 0.149 -9999.0 0.0 -0.461 7.0 7.0 SHH Np/Cholesterol/PTCH2 0.01 0.066 -9999.0 0.0 -0.495 3.0 3.0 SHH Np/Cholesterol/Megalin -0.044 0.177 -9999.0 0.0 -0.519 25.0 25.0 SHH 0.007 0.081 -9999.0 0.0 -0.622 3.0 3.0 catabolic process -0.021 0.171 -9999.0 0.0 -0.482 25.0 25.0 SMO/Vitamin D3 -0.014 0.167 -9999.0 0.0 -0.555 5.0 5.0 SHH Np/Cholesterol/Hhip -0.014 0.122 -9999.0 0.0 -0.478 13.0 13.0 LRP2 -0.077 0.255 -9999.0 0.0 -0.809 23.0 23.0 receptor-mediated endocytosis -0.089 0.195 -9999.0 0.0 -0.67 14.0 14.0 SHH Np/Cholesterol/BOC 0.012 0.065 -9999.0 0.0 -0.495 3.0 3.0 SHH Np/Cholesterol/CDO 0.009 0.067 -9999.0 0.0 -0.495 3.0 3.0 mesenchymal cell differentiation 0.014 0.121 0.475 13.0 -9999.0 0.0 13.0 mol:Vitamin D3 -0.011 0.152 -9999.0 0.0 -0.462 7.0 7.0 IHH N/PTCH2 -0.046 0.183 -9999.0 0.0 -0.543 25.0 25.0 CDON 0.007 0.04 -9999.0 0.0 -0.284 4.0 4.0 IHH N/PTCH1 -0.021 0.173 -9999.0 0.0 -0.489 25.0 25.0 Megalin/LRPAP1 -0.051 0.198 -9999.0 0.0 -0.62 23.0 23.0 PTCH2 0.009 0.029 -9999.0 0.0 -0.284 2.0 2.0 SHH Np/Cholesterol -0.01 0.062 -9999.0 0.0 -0.502 3.0 3.0 PTCH1 -0.021 0.171 -9999.0 0.0 -0.484 25.0 25.0 HHIP -0.027 0.168 -9999.0 0.0 -0.678 12.0 12.0