Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.0 0.097 -9999.0 0.0 -0.329 17.0 17.0 epithelial cell differentiation -0.037 0.124 -9999.0 0.0 -0.459 17.0 17.0 CYFIP2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.034 0.089 -9999.0 0.0 -9999.0 0.0 0.0 EGFR 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EPHA2 0.011 0.02 -9999.0 0.0 -0.284 1.0 1.0 MYO6 -0.003 0.127 -9999.0 0.0 -0.435 17.0 17.0 CTNNB1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.092 0.211 -9999.0 0.0 -0.562 31.0 31.0 CTNND1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.002 0.125 -9999.0 0.0 -0.428 17.0 17.0 regulation of calcium-dependent cell-cell adhesion -0.041 0.191 -9999.0 0.0 -0.486 31.0 31.0 EGF -0.724 0.249 -9999.0 0.0 -0.809 191.0 191.0 NCKAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.224 0.307 -9999.0 0.0 -0.632 72.0 72.0 cortical microtubule organization -0.037 0.124 -9999.0 0.0 -0.459 17.0 17.0 GO:0000145 -0.002 0.12 -9999.0 0.0 -0.408 17.0 17.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.037 0.126 -9999.0 0.0 -0.464 17.0 17.0 MLLT4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.029 0.097 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.009 0.12 -9999.0 0.0 -0.4 17.0 17.0 PVRL2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.003 0.127 -9999.0 0.0 -0.435 17.0 17.0 ARF6/GTP -0.0 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.053 0.222 -9999.0 0.0 -0.809 17.0 17.0 EGFR/EGFR/EGF/EGF -0.412 0.171 -9999.0 0.0 -0.455 193.0 193.0 RhoA/GDP -0.034 0.117 -9999.0 0.0 -0.43 17.0 17.0 actin cytoskeleton organization 0.004 0.122 -9999.0 0.0 -0.411 17.0 17.0 IGF-1R heterotetramer 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.007 0.124 -9999.0 0.0 -0.809 5.0 5.0 DIAPH1 -0.002 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.037 0.124 0.459 17.0 -9999.0 0.0 17.0 RHOA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.029 0.099 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.004 0.125 -9999.0 0.0 -0.421 17.0 17.0 EFNA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.005 0.122 -9999.0 0.0 -0.409 17.0 17.0 Ephrin A1/EPHA2 -0.034 0.113 -9999.0 0.0 -0.417 17.0 17.0 SEC6/SEC8 -0.031 0.104 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.042 0.195 -9999.0 0.0 -0.496 31.0 31.0 HGF/MET -0.067 0.151 -9999.0 0.0 -0.443 28.0 28.0 HGF -0.034 0.189 -9999.0 0.0 -0.809 12.0 12.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.0 0.098 -9999.0 0.0 -0.332 17.0 17.0 actin cable formation 0.05 0.086 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.003 0.125 -9999.0 0.0 -0.41 18.0 18.0 KIFC3 -0.003 0.127 -9999.0 0.0 -0.435 17.0 17.0 NCK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.003 0.127 -9999.0 0.0 -0.435 17.0 17.0 NCK1/GIT1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.037 0.124 -9999.0 0.0 -0.459 17.0 17.0 EXOC4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.003 0.127 -9999.0 0.0 -0.435 17.0 17.0 PIP5K1C -0.003 0.127 -9999.0 0.0 -0.435 17.0 17.0 LIMA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.027 0.102 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.02 0.119 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.043 0.127 -9999.0 0.0 -0.418 22.0 22.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.021 0.094 -9999.0 0.0 -0.284 24.0 24.0 PLEKHA7 -0.005 0.131 -9999.0 0.0 -0.436 18.0 18.0 mol:GTP -0.001 0.008 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.023 0.114 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.0 0.097 -9999.0 0.0 -0.329 17.0 17.0 regulation of cell-cell adhesion 0.004 0.122 -9999.0 0.0 -0.411 17.0 17.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.0 0.098 -9999.0 0.0 -0.332 17.0 17.0