Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	98.0	3365.0	34.0	-0.606	0.012	1000.0	-1000.0	-0.064	-1000.0
EGFR-dependent Endothelin signaling events	82.0	1737.0	21.0	-0.724	0.018	1000.0	-1000.0	-0.065	-1000.0
Angiopoietin receptor Tie2-mediated signaling	69.0	6074.0	88.0	-0.937	0.081	1000.0	-1000.0	-0.092	-1000.0
FOXA2 and FOXA3 transcription factor networks	63.0	2940.0	46.0	-1.257	0.019	1000.0	-1000.0	-0.065	-1000.0
PDGFR-alpha signaling pathway	44.0	1941.0	44.0	-0.315	0.027	1000.0	-1000.0	-0.054	-1000.0
Thromboxane A2 receptor signaling	35.0	3702.0	105.0	-0.724	0.078	1000.0	-1000.0	-0.063	-1000.0
Arf6 signaling events	31.0	1922.0	62.0	-0.724	0.031	1000.0	-1000.0	-0.056	-1000.0
Glypican 1 network	31.0	1492.0	48.0	-0.423	0.03	1000.0	-1000.0	-0.043	-1000.0
Glypican 2 network	30.0	123.0	4.0	-0.116	-0.111	1000.0	-1000.0	-0.019	-1000.0
Signaling mediated by p38-alpha and p38-beta	27.0	1210.0	44.0	-0.172	0.012	1000.0	-1000.0	-0.047	-1000.0
Syndecan-4-mediated signaling events	26.0	1787.0	67.0	-0.451	0.074	1000.0	-1000.0	-0.083	-1000.0
TCGA08_retinoblastoma	25.0	201.0	8.0	-0.225	0.06	1000.0	-1000.0	-0.017	-1000.0
amb2 Integrin signaling	24.0	2014.0	82.0	-0.482	0.012	1000.0	-1000.0	-0.081	-1000.0
BMP receptor signaling	23.0	1878.0	81.0	-0.505	0.018	1000.0	-1000.0	-0.099	-1000.0
Endothelins	23.0	2293.0	96.0	-0.602	0.012	1000.0	-1000.0	-0.08	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	22.0	2753.0	125.0	-0.154	0.018	1000.0	-1000.0	-0.09	-1000.0
IL4-mediated signaling events	21.0	1944.0	91.0	-0.888	0.485	1000.0	-1000.0	-0.129	-1000.0
FOXM1 transcription factor network	21.0	1075.0	51.0	-0.224	0.023	1000.0	-1000.0	-0.16	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	21.0	1681.0	78.0	-0.301	0.04	1000.0	-1000.0	-0.066	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	20.0	1390.0	68.0	-0.593	0.085	1000.0	-1000.0	-0.122	-1000.0
Integrins in angiogenesis	19.0	1648.0	84.0	-0.556	0.036	1000.0	-1000.0	-0.093	-1000.0
S1P1 pathway	18.0	676.0	36.0	-0.17	0.012	1000.0	-1000.0	-0.05	-1000.0
Effects of Botulinum toxin	18.0	490.0	26.0	-0.208	0.015	1000.0	-1000.0	-0.062	-1000.0
Signaling events mediated by PTP1B	17.0	1364.0	76.0	-0.729	0.102	1000.0	-1000.0	-0.079	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	16.0	1985.0	120.0	-0.323	0.139	1000.0	-1000.0	-0.071	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	14.0	1102.0	74.0	-0.724	0.05	1000.0	-1000.0	-0.087	-1000.0
Syndecan-1-mediated signaling events	13.0	460.0	34.0	-0.099	0.012	1000.0	-1000.0	-0.047	-1000.0
TCR signaling in naïve CD8+ T cells	13.0	1220.0	93.0	-0.554	0.261	1000.0	-1000.0	-0.082	-1000.0
LPA4-mediated signaling events	12.0	144.0	12.0	-0.246	0.018	1000.0	-1000.0	-0.025	-1000.0
Signaling events mediated by the Hedgehog family	11.0	585.0	52.0	-0.089	0.018	1000.0	-1000.0	-0.072	-1000.0
FoxO family signaling	11.0	756.0	64.0	-0.941	0.087	1000.0	-1000.0	-0.063	-1000.0
Coregulation of Androgen receptor activity	10.0	780.0	76.0	-0.743	0.022	1000.0	-1000.0	-0.042	-1000.0
Sphingosine 1-phosphate (S1P) pathway	10.0	290.0	28.0	-0.165	0.017	1000.0	-1000.0	-0.031	-1000.0
Ephrin A  reverse signaling	10.0	75.0	7.0	-0.047	-0.0	1000.0	-1000.0	-0.035	-1000.0
Nongenotropic Androgen signaling	10.0	568.0	52.0	-0.095	0.027	1000.0	-1000.0	-0.053	-1000.0
IL27-mediated signaling events	10.0	518.0	51.0	-1.01	0.173	1000.0	-1000.0	-0.068	-1000.0
IL6-mediated signaling events	10.0	777.0	75.0	-0.264	0.052	1000.0	-1000.0	-0.079	-1000.0
Plasma membrane estrogen receptor signaling	10.0	867.0	86.0	-0.165	0.024	1000.0	-1000.0	-0.079	-1000.0
S1P3 pathway	10.0	444.0	42.0	-0.165	0.019	1000.0	-1000.0	-0.032	-1000.0
E-cadherin signaling events	10.0	51.0	5.0	-0.053	0.012	1000.0	-1000.0	-0.037	-1000.0
Aurora B signaling	10.0	675.0	67.0	-0.294	0.012	1000.0	-1000.0	-0.073	-1000.0
ErbB4 signaling events	9.0	642.0	69.0	-0.366	0.116	1000.0	-1000.0	-0.088	-1000.0
p75(NTR)-mediated signaling	9.0	1232.0	125.0	-0.459	0.031	1000.0	-1000.0	-0.097	-1000.0
Glucocorticoid receptor regulatory network	9.0	1115.0	114.0	-0.614	0.161	1000.0	-1000.0	-0.072	-1000.0
Signaling events regulated by Ret tyrosine kinase	9.0	763.0	82.0	-0.123	0.012	1000.0	-1000.0	-0.077	-1000.0
Calcium signaling in the CD4+ TCR pathway	9.0	284.0	31.0	-0.14	0.015	1000.0	-1000.0	-0.086	-1000.0
Wnt signaling	9.0	68.0	7.0	-0.039	0.012	1000.0	-1000.0	-0.03	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	8.0	436.0	54.0	-0.214	0.025	1000.0	-1000.0	-0.092	-1000.0
Noncanonical Wnt signaling pathway	8.0	217.0	26.0	-0.197	0.013	1000.0	-1000.0	-0.061	-1000.0
Presenilin action in Notch and Wnt signaling	8.0	498.0	61.0	-0.205	0.096	1000.0	-1000.0	-0.071	-1000.0
Reelin signaling pathway	8.0	479.0	56.0	-0.179	0.018	1000.0	-1000.0	-0.069	-1000.0
Regulation of nuclear SMAD2/3 signaling	7.0	1025.0	136.0	-0.591	0.067	1000.0	-1000.0	-0.073	-1000.0
HIF-1-alpha transcription factor network	7.0	579.0	76.0	-0.131	0.05	1000.0	-1000.0	-0.16	-1000.0
Regulation of Telomerase	7.0	744.0	102.0	-0.724	0.042	1000.0	-1000.0	-0.107	-1000.0
IL23-mediated signaling events	7.0	449.0	60.0	-0.113	0.024	1000.0	-1000.0	-0.129	-1000.0
Visual signal transduction: Rods	7.0	368.0	52.0	-0.204	0.012	1000.0	-1000.0	-0.084	-1000.0
E-cadherin signaling in keratinocytes	7.0	337.0	43.0	-0.272	0.035	1000.0	-1000.0	-0.062	-1000.0
IL12-mediated signaling events	6.0	601.0	87.0	-0.185	0.024	1000.0	-1000.0	-0.126	-1000.0
PLK2 and PLK4 events	6.0	18.0	3.0	-0.01	0.009	1000.0	-1000.0	-0.014	-1000.0
Osteopontin-mediated events	6.0	247.0	38.0	-0.118	0.045	1000.0	-1000.0	-0.096	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	6.0	348.0	52.0	-0.335	0.054	1000.0	-1000.0	-0.058	-1000.0
Syndecan-3-mediated signaling events	6.0	237.0	35.0	-0.176	0.018	1000.0	-1000.0	-0.063	-1000.0
E-cadherin signaling in the nascent adherens junction	6.0	480.0	76.0	-0.053	0.029	1000.0	-1000.0	-0.074	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	6.0	212.0	33.0	-0.224	0.035	1000.0	-1000.0	-0.066	-1000.0
PDGFR-beta signaling pathway	6.0	626.0	97.0	-0.126	0.042	1000.0	-1000.0	-0.071	-1000.0
Class IB PI3K non-lipid kinase events	6.0	18.0	3.0	-0.007	-1000.0	1000.0	-1000.0	-0.015	-1000.0
Regulation of Androgen receptor activity	6.0	453.0	70.0	-0.837	0.027	1000.0	-1000.0	-0.064	-1000.0
Caspase cascade in apoptosis	5.0	408.0	74.0	-0.418	0.039	1000.0	-1000.0	-0.041	-1000.0
Syndecan-2-mediated signaling events	5.0	360.0	69.0	-0.482	0.039	1000.0	-1000.0	-0.044	-1000.0
Ceramide signaling pathway	5.0	446.0	76.0	-0.724	0.249	1000.0	-1000.0	-0.064	-1000.0
EPHB forward signaling	5.0	496.0	85.0	-0.177	0.06	1000.0	-1000.0	-0.085	-1000.0
BCR signaling pathway	5.0	569.0	99.0	-0.083	0.029	1000.0	-1000.0	-0.09	-1000.0
S1P4 pathway	5.0	149.0	25.0	-0.054	0.027	1000.0	-1000.0	-0.045	-1000.0
BARD1 signaling events	4.0	243.0	57.0	-0.109	0.025	1000.0	-1000.0	-0.064	-1000.0
IFN-gamma pathway	4.0	275.0	68.0	-0.385	0.065	1000.0	-1000.0	-0.089	-1000.0
IL1-mediated signaling events	4.0	256.0	62.0	-0.144	0.058	1000.0	-1000.0	-0.098	-1000.0
Canonical Wnt signaling pathway	4.0	211.0	51.0	-0.205	0.102	1000.0	-1000.0	-0.063	-1000.0
TCGA08_rtk_signaling	4.0	114.0	26.0	-0.265	0.029	1000.0	-1000.0	-0.021	-1000.0
Ras signaling in the CD4+ TCR pathway	4.0	77.0	17.0	-0.012	0.025	1000.0	-1000.0	-0.048	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	3.0	332.0	85.0	-0.119	0.035	1000.0	-1000.0	-0.072	-1000.0
Fc-epsilon receptor I signaling in mast cells	3.0	368.0	97.0	-0.119	0.029	1000.0	-1000.0	-0.087	-1000.0
S1P5 pathway	3.0	67.0	17.0	-0.054	0.027	1000.0	-1000.0	-0.043	-1000.0
IL2 signaling events mediated by PI3K	3.0	195.0	58.0	-0.056	0.056	1000.0	-1000.0	-0.085	-1000.0
Regulation of p38-alpha and p38-beta	3.0	206.0	54.0	-0.173	0.06	1000.0	-1000.0	-0.059	-1000.0
LPA receptor mediated events	3.0	382.0	102.0	-0.119	0.053	1000.0	-1000.0	-0.089	-1000.0
IL2 signaling events mediated by STAT5	3.0	86.0	22.0	-0.05	0.043	1000.0	-1000.0	-0.046	-1000.0
Class I PI3K signaling events	3.0	221.0	73.0	-0.044	0.038	1000.0	-1000.0	-0.074	-1000.0
ErbB2/ErbB3 signaling events	2.0	141.0	65.0	-0.114	0.032	1000.0	-1000.0	-0.064	-1000.0
JNK signaling in the CD4+ TCR pathway	2.0	38.0	17.0	-0.03	0.029	1000.0	-1000.0	-0.067	-1000.0
Cellular roles of Anthrax toxin	2.0	106.0	39.0	-0.19	0.018	1000.0	-1000.0	-0.034	-1000.0
PLK1 signaling events	2.0	228.0	85.0	-0.092	0.023	1000.0	-1000.0	-0.043	-1000.0
Insulin-mediated glucose transport	2.0	71.0	32.0	-0.125	0.063	1000.0	-1000.0	-0.075	-1000.0
Nectin adhesion pathway	2.0	144.0	63.0	-0.089	0.049	1000.0	-1000.0	-0.071	-1000.0
Ephrin B reverse signaling	2.0	137.0	48.0	-0.072	0.031	1000.0	-1000.0	-0.06	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	180.0	83.0	-0.274	0.047	1000.0	-1000.0	-0.067	-1000.0
FAS signaling pathway (CD95)	2.0	129.0	47.0	-0.103	0.021	1000.0	-1000.0	-0.04	-1000.0
Retinoic acid receptors-mediated signaling	2.0	127.0	58.0	-0.06	0.032	1000.0	-1000.0	-0.065	-1000.0
Arf6 trafficking events	2.0	209.0	71.0	-0.346	0.04	1000.0	-1000.0	-0.071	-1000.0
IGF1 pathway	2.0	168.0	57.0	-0.036	0.04	1000.0	-1000.0	-0.089	-1000.0
Signaling events mediated by PRL	2.0	93.0	34.0	-0.031	0.021	1000.0	-1000.0	-0.04	-1000.0
Signaling events mediated by HDAC Class II	1.0	112.0	75.0	-0.127	0.036	1000.0	-1000.0	-0.061	-1000.0
Visual signal transduction: Cones	1.0	49.0	38.0	-0.015	0.014	1000.0	-1000.0	-0.066	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	74.0	65.0	-0.053	0.062	1000.0	-1000.0	-0.071	-1000.0
Aurora A signaling	1.0	115.0	60.0	-0.11	0.038	1000.0	-1000.0	-0.057	-1000.0
HIF-2-alpha transcription factor network	1.0	73.0	43.0	-0.207	0.125	1000.0	-1000.0	-0.095	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	24.0	15.0	-0.0	0.025	1000.0	-1000.0	-0.029	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	46.0	45.0	-0.024	0.057	1000.0	-1000.0	-0.079	-1000.0
Insulin Pathway	1.0	111.0	74.0	-0.038	0.033	1000.0	-1000.0	-0.088	-1000.0
VEGFR1 specific signals	1.0	90.0	56.0	-0.009	0.045	1000.0	-1000.0	-0.068	-1000.0
p38 MAPK signaling pathway	1.0	45.0	44.0	-0.037	0.039	1000.0	-1000.0	-0.056	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	6.0	23.0	0.0	0.044	1000.0	-1000.0	-0.062	-1000.0
Canonical NF-kappaB pathway	0.0	16.0	39.0	-0.012	0.075	1000.0	-1000.0	-0.084	-1000.0
Circadian rhythm pathway	0.0	6.0	22.0	-0.012	0.043	1000.0	-1000.0	-0.041	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.012	0.018	1000.0	-1000.0	-0.023	-1000.0
Arf6 downstream pathway	0.0	0.0	43.0	-0.024	0.024	1000.0	-1000.0	-0.031	-1000.0
Aurora C signaling	0.0	0.0	7.0	-0.124	0.012	1000.0	-1000.0	-0.027	-1000.0
EPO signaling pathway	0.0	49.0	55.0	-0.039	0.073	1000.0	-1000.0	-0.092	-1000.0
mTOR signaling pathway	0.0	40.0	53.0	-0.007	0.032	1000.0	-1000.0	-0.059	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	5.0	68.0	-0.125	0.046	1000.0	-1000.0	-0.05	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	33.0	37.0	-0.032	0.035	1000.0	-1000.0	-0.054	-1000.0
Signaling events mediated by HDAC Class III	0.0	20.0	40.0	-0.019	0.021	1000.0	-1000.0	-0.047	-1000.0
TRAIL signaling pathway	0.0	37.0	48.0	-0.013	0.043	1000.0	-1000.0	-0.068	-1000.0
ceramide signaling pathway	0.0	34.0	49.0	-0.012	0.045	1000.0	-1000.0	-0.047	-1000.0
Signaling events mediated by HDAC Class I	0.0	101.0	104.0	-0.127	0.052	1000.0	-1000.0	-0.064	-1000.0
TCGA08_p53	0.0	0.0	7.0	-0.15	0.094	1000.0	-1000.0	-0.012	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	0.0	36.0	-0.036	0.037	1000.0	-1000.0	-0.068	-1000.0
Atypical NF-kappaB pathway	0.0	15.0	31.0	-0.0	0.044	1000.0	-1000.0	-0.04	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.002	0.031	1000.0	-1000.0	-0.051	-1000.0
Rapid glucocorticoid signaling	0.0	8.0	20.0	-0.002	0.012	1000.0	-1000.0	-0.043	-1000.0
Arf1 pathway	0.0	8.0	54.0	-0.005	0.03	1000.0	-1000.0	-0.044	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.018	1000.0	-1000.0	-0.062	-1000.0
Total	1300	77825	7203	-31.4119591952	-994.01756219	131000	-131000	-8.5902439128	-131000