E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.022 0.149 -9999.0 0.0 -0.523 16.0 16.0 KLHL20 0.014 0.087 0.204 2.0 -0.292 2.0 4.0 CYFIP2 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP -0.004 0.113 0.414 2.0 -0.334 14.0 16.0 ENAH -0.023 0.149 -9999.0 0.0 -0.52 16.0 16.0 AP1M1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.004 0.079 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.017 0.042 -9999.0 0.0 -0.195 2.0 2.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.027 0.122 -9999.0 0.0 -0.398 15.0 15.0 RAPGEF1 -0.018 0.133 -9999.0 0.0 -0.456 15.0 15.0 CTNND1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.017 0.155 -9999.0 0.0 -0.536 16.0 16.0 CRK -0.024 0.136 -9999.0 0.0 -0.493 15.0 15.0 E-cadherin/gamma catenin/alpha catenin 0.014 0.126 -9999.0 0.0 -0.419 16.0 16.0 alphaE/beta7 Integrin 0.037 0.013 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.048 0.017 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.023 0.15 -9999.0 0.0 -0.523 16.0 16.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.009 0.055 -9999.0 0.0 -0.216 1.0 1.0 MLLT4 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.043 0.022 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.008 0.072 -9999.0 0.0 -0.28 1.0 1.0 ARF6 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.003 0.139 -9999.0 0.0 -0.483 16.0 16.0 TIAM1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.026 0.117 -9999.0 0.0 -0.376 16.0 16.0 AKT1 -0.011 0.045 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.026 0.181 -9999.0 0.0 -0.657 16.0 16.0 RhoA/GDP 0.008 0.124 0.401 5.0 -0.333 15.0 20.0 actin cytoskeleton organization 0.02 0.074 0.201 7.0 -0.208 2.0 9.0 CDC42/GDP 0.018 0.14 0.48 7.0 -0.331 15.0 22.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.004 0.082 -9999.0 0.0 -0.293 15.0 15.0 ITGB7 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.022 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.029 0.124 -9999.0 0.0 -0.398 16.0 16.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.012 0.112 -9999.0 0.0 -0.374 16.0 16.0 mol:GDP 0.0 0.154 0.5 7.0 -0.386 15.0 22.0 CDC42/GTP/IQGAP1 0.035 0.011 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.008 0.115 0.37 1.0 -0.341 15.0 16.0 RAC1/GTP/IQGAP1 0.029 0.016 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.041 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.026 0.074 0.242 11.0 -0.272 1.0 12.0 NME1 0.025 0.012 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.023 0.149 -9999.0 0.0 -0.522 16.0 16.0 regulation of cell-cell adhesion -0.001 0.068 -9999.0 0.0 -0.249 1.0 1.0 WASF2 0.01 0.033 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.008 0.093 -9999.0 0.0 -0.314 3.0 3.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.036 0.119 -9999.0 0.0 -0.379 15.0 15.0 CCND1 0.027 0.079 0.248 10.0 -0.347 1.0 11.0 VAV2 -0.038 0.196 -9999.0 0.0 -0.517 27.0 27.0 RAP1/GDP 0.013 0.107 0.323 3.0 -0.325 5.0 8.0 adherens junction assembly -0.022 0.144 -9999.0 0.0 -0.504 16.0 16.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.024 0.112 -9999.0 0.0 -0.366 15.0 15.0 E-cadherin/beta catenin -0.022 0.116 -9999.0 0.0 -0.426 16.0 16.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.023 0.15 -9999.0 0.0 -0.523 16.0 16.0 PIK3CA 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.025 0.106 -9999.0 0.0 -0.398 5.0 5.0 E-cadherin/beta catenin/alpha catenin 0.014 0.129 -9999.0 0.0 -0.431 16.0 16.0 ITGAE 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.018 0.159 -9999.0 0.0 -0.549 16.0 16.0