Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.012 0.121 -9999.0 0.0 -0.388 2.0 2.0 IHH -0.049 0.233 -9999.0 0.0 -0.682 25.0 25.0 SHH Np/Cholesterol/GAS1 -0.001 0.085 -9999.0 0.0 -0.329 12.0 12.0 LRPAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.001 0.085 0.327 12.0 -9999.0 0.0 12.0 SMO/beta Arrestin2 -0.018 0.15 -9999.0 0.0 -0.42 20.0 20.0 SMO -0.029 0.148 -9999.0 0.0 -0.44 20.0 20.0 AKT1 -0.023 0.147 -9999.0 0.0 -0.626 7.0 7.0 ARRB2 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.029 0.146 -9999.0 0.0 -0.434 20.0 20.0 STIL 0.009 0.132 0.257 1.0 -0.334 6.0 7.0 DHH N/PTCH2 0.016 0.102 -9999.0 0.0 -0.494 8.0 8.0 DHH N/PTCH1 -0.019 0.151 -9999.0 0.0 -0.368 32.0 32.0 PIK3CA 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.002 0.131 -9999.0 0.0 -0.657 8.0 8.0 PTHLH -0.025 0.149 -9999.0 0.0 -0.488 2.0 2.0 determination of left/right symmetry -0.029 0.146 -9999.0 0.0 -0.434 20.0 20.0 PIK3R1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.025 0.148 -9999.0 0.0 -0.485 2.0 2.0 IHH N/Hhip -0.039 0.187 -9999.0 0.0 -0.463 34.0 34.0 DHH N/Hhip -0.006 0.155 -9999.0 0.0 -0.547 15.0 15.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.029 0.146 -9999.0 0.0 -0.434 20.0 20.0 pancreas development -0.007 0.138 -9999.0 0.0 -0.656 9.0 9.0 HHAT 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.04 0.009 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.003 0.135 -9999.0 0.0 -0.594 10.0 10.0 somite specification -0.029 0.146 -9999.0 0.0 -0.434 20.0 20.0 SHH Np/Cholesterol/PTCH1 -0.017 0.111 -9999.0 0.0 -0.322 20.0 20.0 SHH Np/Cholesterol/PTCH2 0.013 0.051 -9999.0 0.0 -0.389 3.0 3.0 SHH Np/Cholesterol/Megalin -0.031 0.141 -9999.0 0.0 -0.41 25.0 25.0 SHH 0.002 0.061 -9999.0 0.0 -0.497 3.0 3.0 catabolic process -0.018 0.138 -9999.0 0.0 -0.39 25.0 25.0 SMO/Vitamin D3 -0.022 0.131 -9999.0 0.0 -0.384 21.0 21.0 SHH Np/Cholesterol/Hhip -0.005 0.094 -9999.0 0.0 -0.396 11.0 11.0 LRP2 -0.047 0.213 -9999.0 0.0 -0.657 23.0 23.0 receptor-mediated endocytosis -0.054 0.179 -9999.0 0.0 -0.55 16.0 16.0 SHH Np/Cholesterol/BOC 0.014 0.051 -9999.0 0.0 -0.395 3.0 3.0 SHH Np/Cholesterol/CDO 0.013 0.052 -9999.0 0.0 -0.395 3.0 3.0 mesenchymal cell differentiation 0.005 0.094 0.393 11.0 -9999.0 0.0 11.0 mol:Vitamin D3 0.017 0.141 0.369 1.0 -0.325 20.0 21.0 IHH N/PTCH2 -0.015 0.155 -9999.0 0.0 -0.435 25.0 25.0 CDON 0.026 0.013 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.01 0.142 -9999.0 0.0 -0.394 25.0 25.0 Megalin/LRPAP1 -0.018 0.167 -9999.0 0.0 -0.494 23.0 23.0 PTCH2 0.025 0.012 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.006 0.049 -9999.0 0.0 -0.393 3.0 3.0 PTCH1 -0.018 0.138 -9999.0 0.0 -0.391 25.0 25.0 HHIP -0.007 0.138 -9999.0 0.0 -0.657 9.0 9.0