Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.0 0.082 -9999.0 0.0 -0.285 16.0 16.0 epithelial cell differentiation 0.021 0.114 -9999.0 0.0 -0.372 16.0 16.0 CYFIP2 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.003 0.133 0.493 9.0 -9999.0 0.0 9.0 EGFR 0.022 0.011 -9999.0 0.0 -9999.0 0.0 0.0 EPHA2 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.019 0.119 0.342 6.0 -0.36 16.0 22.0 CTNNB1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.053 0.016 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.071 0.193 -9999.0 0.0 -0.58 22.0 22.0 CTNND1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.018 0.12 0.34 7.0 -0.355 16.0 23.0 regulation of calcium-dependent cell-cell adhesion -0.044 0.147 0.346 4.0 -0.394 25.0 29.0 EGF -0.572 0.216 -9999.0 0.0 -0.644 188.0 188.0 NCKAP1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.163 0.266 -9999.0 0.0 -0.569 58.0 58.0 cortical microtubule organization 0.021 0.114 -9999.0 0.0 -0.372 16.0 16.0 GO:0000145 -0.017 0.115 0.329 7.0 -0.339 16.0 23.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.026 0.117 -9999.0 0.0 -0.376 16.0 16.0 MLLT4 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.037 0.079 -9999.0 0.0 -0.325 12.0 12.0 ARF6 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.059 0.028 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.013 0.101 0.344 2.0 -0.333 15.0 17.0 PVRL2 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.023 0.108 0.348 3.0 -0.36 15.0 18.0 ARF6/GTP 0.064 0.032 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.026 0.181 -9999.0 0.0 -0.657 16.0 16.0 EGFR/EGFR/EGF/EGF -0.285 0.169 -9999.0 0.0 -0.387 135.0 135.0 RhoA/GDP 0.023 0.111 -9999.0 0.0 -0.357 16.0 16.0 actin cytoskeleton organization -0.019 0.115 0.326 6.0 -0.349 16.0 22.0 IGF-1R heterotetramer 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.011 0.104 -9999.0 0.0 -0.657 5.0 5.0 DIAPH1 0.037 0.101 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway -0.021 0.114 0.372 16.0 -9999.0 0.0 16.0 RHOA 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.038 0.08 -9999.0 0.0 -0.329 13.0 13.0 CTNNA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.02 0.117 0.328 6.0 -0.357 16.0 22.0 EFNA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.026 0.105 0.341 3.0 -0.343 16.0 19.0 Ephrin A1/EPHA2 0.015 0.106 -9999.0 0.0 -0.348 16.0 16.0 SEC6/SEC8 -0.036 0.085 -9999.0 0.0 -0.338 15.0 15.0 MGAT3 -0.045 0.15 0.348 4.0 -0.401 25.0 29.0 HGF/MET -0.005 0.126 -9999.0 0.0 -0.368 21.0 21.0 HGF -0.007 0.138 -9999.0 0.0 -0.657 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.0 0.083 -9999.0 0.0 -0.287 16.0 16.0 actin cable formation 0.027 0.153 0.551 11.0 -9999.0 0.0 11.0 KIAA1543 -0.019 0.119 0.331 7.0 -0.343 17.0 24.0 KIFC3 -0.035 0.095 -9999.0 0.0 -0.36 16.0 16.0 NCK1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.017 0.121 0.343 7.0 -0.357 16.0 23.0 NCK1/GIT1 0.038 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.021 0.114 -9999.0 0.0 -0.372 16.0 16.0 EXOC4 0.023 0.011 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.035 0.094 -9999.0 0.0 -0.36 16.0 16.0 PIP5K1C -0.018 0.121 0.343 7.0 -0.36 16.0 23.0 LIMA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.001 0.148 0.51 10.0 -9999.0 0.0 10.0 adherens junction assembly 0.002 0.131 0.397 10.0 -9999.0 0.0 10.0 IGF-1R heterotetramer/IGF1 0.007 0.121 -9999.0 0.0 -0.351 21.0 21.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.04 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.017 0.024 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.019 0.124 0.343 7.0 -0.36 17.0 24.0 mol:GTP 0.057 0.027 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.006 0.113 0.313 1.0 -9999.0 0.0 1.0 cortical actin cytoskeleton stabilization 0.0 0.082 -9999.0 0.0 -0.285 16.0 16.0 regulation of cell-cell adhesion -0.019 0.115 0.326 6.0 -0.349 16.0 22.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.0 0.083 -9999.0 0.0 -0.287 16.0 16.0