Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	94.0	3222.0	34.0	-0.468	0.028	1000.0	-1000.0	-0.038	-1000.0
Angiopoietin receptor Tie2-mediated signaling	68.0	6016.0	88.0	-0.857	0.092	1000.0	-1000.0	-0.065	-1000.0
FOXA2 and FOXA3 transcription factor networks	66.0	3077.0	46.0	-1.144	0.03	1000.0	-1000.0	-0.095	-1000.0
EGFR-dependent Endothelin signaling events	62.0	1313.0	21.0	-0.572	0.038	1000.0	-1000.0	-0.05	-1000.0
PDGFR-alpha signaling pathway	41.0	1847.0	44.0	-0.253	0.037	1000.0	-1000.0	-0.042	-1000.0
Thromboxane A2 receptor signaling	35.0	3688.0	105.0	-0.572	0.095	1000.0	-1000.0	-0.048	-1000.0
Glypican 1 network	29.0	1411.0	48.0	-0.342	0.051	1000.0	-1000.0	-0.037	-1000.0
Signaling mediated by p38-alpha and p38-beta	28.0	1255.0	44.0	-0.152	0.027	1000.0	-1000.0	-0.033	-1000.0
BMP receptor signaling	26.0	2145.0	81.0	-0.374	0.055	1000.0	-1000.0	-0.054	-1000.0
Endothelins	22.0	2121.0	96.0	-0.596	0.039	1000.0	-1000.0	-0.056	-1000.0
Arf6 signaling events	21.0	1343.0	62.0	-0.572	0.059	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	20.0	2581.0	125.0	-0.132	0.061	1000.0	-1000.0	-0.058	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	20.0	1630.0	78.0	-0.246	0.052	1000.0	-1000.0	-0.05	-1000.0
Integrins in angiogenesis	19.0	1608.0	84.0	-0.437	0.06	1000.0	-1000.0	-0.052	-1000.0
IL4-mediated signaling events	17.0	1622.0	91.0	-0.835	0.442	1000.0	-1000.0	-0.101	-1000.0
Signaling events mediated by PTP1B	16.0	1289.0	76.0	-0.575	0.089	1000.0	-1000.0	-0.045	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	16.0	1129.0	68.0	-0.469	0.079	1000.0	-1000.0	-0.086	-1000.0
amb2 Integrin signaling	15.0	1286.0	82.0	-0.389	0.038	1000.0	-1000.0	-0.039	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	15.0	1865.0	120.0	-0.247	0.118	1000.0	-1000.0	-0.053	-1000.0
Ceramide signaling pathway	14.0	1079.0	76.0	-0.572	0.201	1000.0	-1000.0	-0.035	-1000.0
S1P1 pathway	14.0	514.0	36.0	-0.139	0.027	1000.0	-1000.0	-0.044	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	14.0	1104.0	74.0	-0.572	0.064	1000.0	-1000.0	-0.07	-1000.0
FoxO family signaling	13.0	837.0	64.0	-0.888	0.063	1000.0	-1000.0	-0.058	-1000.0
Signaling events mediated by the Hedgehog family	11.0	600.0	52.0	-0.054	0.04	1000.0	-1000.0	-0.041	-1000.0
Plasma membrane estrogen receptor signaling	11.0	981.0	86.0	-0.124	0.048	1000.0	-1000.0	-0.061	-1000.0
LPA4-mediated signaling events	10.0	123.0	12.0	-0.15	0.007	1000.0	-1000.0	-0.027	-1000.0
Ephrin A  reverse signaling	10.0	75.0	7.0	-0.032	0.0	1000.0	-1000.0	-0.017	-1000.0
Glucocorticoid receptor regulatory network	10.0	1185.0	114.0	-0.544	0.131	1000.0	-1000.0	-0.049	-1000.0
TCR signaling in naïve CD8+ T cells	9.0	842.0	93.0	-0.22	0.107	1000.0	-1000.0	-0.062	-1000.0
Nongenotropic Androgen signaling	9.0	517.0	52.0	-0.117	0.051	1000.0	-1000.0	-0.047	-1000.0
E-cadherin signaling events	9.0	48.0	5.0	-0.026	0.027	1000.0	-1000.0	-0.003	-1000.0
Caspase cascade in apoptosis	8.0	632.0	74.0	-0.42	0.066	1000.0	-1000.0	-0.045	-1000.0
Noncanonical Wnt signaling pathway	8.0	231.0	26.0	-0.167	0.027	1000.0	-1000.0	-0.053	-1000.0
Signaling events regulated by Ret tyrosine kinase	8.0	729.0	82.0	-0.067	0.028	1000.0	-1000.0	-0.064	-1000.0
Syndecan-3-mediated signaling events	8.0	293.0	35.0	-0.105	0.073	1000.0	-1000.0	-0.033	-1000.0
Coregulation of Androgen receptor activity	7.0	595.0	76.0	-0.657	0.05	1000.0	-1000.0	-0.022	-1000.0
ErbB4 signaling events	7.0	533.0	69.0	-0.286	0.089	1000.0	-1000.0	-0.05	-1000.0
p75(NTR)-mediated signaling	7.0	955.0	125.0	-0.372	0.073	1000.0	-1000.0	-0.083	-1000.0
Calcium signaling in the CD4+ TCR pathway	7.0	226.0	31.0	-0.098	0.028	1000.0	-1000.0	-0.044	-1000.0
IL6-mediated signaling events	7.0	573.0	75.0	-0.214	0.041	1000.0	-1000.0	-0.043	-1000.0
S1P3 pathway	7.0	334.0	42.0	-0.113	0.038	1000.0	-1000.0	-0.042	-1000.0
E-cadherin signaling in keratinocytes	7.0	321.0	43.0	-0.21	0.04	1000.0	-1000.0	-0.042	-1000.0
Regulation of nuclear SMAD2/3 signaling	6.0	914.0	136.0	-0.467	0.094	1000.0	-1000.0	-0.044	-1000.0
Osteopontin-mediated events	6.0	233.0	38.0	-0.071	0.051	1000.0	-1000.0	-0.057	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	6.0	570.0	85.0	-0.113	0.109	1000.0	-1000.0	-0.051	-1000.0
Presenilin action in Notch and Wnt signaling	6.0	370.0	61.0	-0.146	0.083	1000.0	-1000.0	-0.06	-1000.0
Reelin signaling pathway	6.0	351.0	56.0	-0.121	0.07	1000.0	-1000.0	-0.049	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	6.0	335.0	52.0	-0.243	0.083	1000.0	-1000.0	-0.039	-1000.0
IL27-mediated signaling events	6.0	318.0	51.0	-0.961	0.243	1000.0	-1000.0	-0.052	-1000.0
TCGA08_rtk_signaling	6.0	161.0	26.0	-0.199	0.063	1000.0	-1000.0	-0.013	-1000.0
E-cadherin signaling in the nascent adherens junction	6.0	526.0	76.0	-0.038	0.048	1000.0	-1000.0	-0.062	-1000.0
Regulation of Telomerase	6.0	645.0	102.0	-0.571	0.07	1000.0	-1000.0	-0.06	-1000.0
IL23-mediated signaling events	6.0	394.0	60.0	-0.061	0.043	1000.0	-1000.0	-0.076	-1000.0
PDGFR-beta signaling pathway	6.0	611.0	97.0	-0.039	0.057	1000.0	-1000.0	-0.073	-1000.0
Visual signal transduction: Rods	6.0	317.0	52.0	-0.147	0.052	1000.0	-1000.0	-0.039	-1000.0
Regulation of Androgen receptor activity	6.0	426.0	70.0	-0.759	0.043	1000.0	-1000.0	-0.053	-1000.0
Sphingosine 1-phosphate (S1P) pathway	5.0	143.0	28.0	-0.113	0.045	1000.0	-1000.0	-0.03	-1000.0
HIF-1-alpha transcription factor network	5.0	421.0	76.0	-0.082	0.096	1000.0	-1000.0	-0.081	-1000.0
IFN-gamma pathway	5.0	376.0	68.0	-0.31	0.066	1000.0	-1000.0	-0.068	-1000.0
ceramide signaling pathway	5.0	286.0	49.0	0.0	0.041	1000.0	-1000.0	-0.038	-1000.0
TCGA08_p53	5.0	39.0	7.0	-0.032	0.029	1000.0	-1000.0	-0.009	-1000.0
EPHB forward signaling	5.0	509.0	85.0	-0.119	0.069	1000.0	-1000.0	-0.077	-1000.0
Effects of Botulinum toxin	5.0	150.0	26.0	-0.147	0.045	1000.0	-1000.0	-0.015	-1000.0
Syndecan-4-mediated signaling events	5.0	356.0	67.0	-0.362	0.104	1000.0	-1000.0	-0.051	-1000.0
Syndecan-1-mediated signaling events	4.0	169.0	34.0	-0.035	0.028	1000.0	-1000.0	-0.051	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	4.0	232.0	54.0	-0.049	0.041	1000.0	-1000.0	-0.062	-1000.0
Cellular roles of Anthrax toxin	4.0	187.0	39.0	-0.144	0.036	1000.0	-1000.0	-0.027	-1000.0
Fc-epsilon receptor I signaling in mast cells	4.0	420.0	97.0	-0.071	0.05	1000.0	-1000.0	-0.068	-1000.0
Ephrin B reverse signaling	4.0	216.0	48.0	-0.024	0.037	1000.0	-1000.0	-0.034	-1000.0
Signaling mediated by p38-gamma and p38-delta	4.0	63.0	15.0	-0.01	0.028	1000.0	-1000.0	-0.039	-1000.0
Regulation of p38-alpha and p38-beta	4.0	250.0	54.0	-0.128	0.067	1000.0	-1000.0	-0.054	-1000.0
Arf6 trafficking events	4.0	301.0	71.0	-0.262	0.046	1000.0	-1000.0	-0.034	-1000.0
BCR signaling pathway	4.0	480.0	99.0	-0.051	0.058	1000.0	-1000.0	-0.062	-1000.0
Signaling events mediated by PRL	4.0	137.0	34.0	-0.041	0.04	1000.0	-1000.0	-0.048	-1000.0
Class IB PI3K non-lipid kinase events	4.0	12.0	3.0	-0.013	0.013	1000.0	-1000.0	-0.009	-1000.0
Ras signaling in the CD4+ TCR pathway	4.0	78.0	17.0	-0.011	0.042	1000.0	-1000.0	-0.038	-1000.0
ErbB2/ErbB3 signaling events	3.0	230.0	65.0	-0.061	0.048	1000.0	-1000.0	-0.055	-1000.0
Syndecan-2-mediated signaling events	3.0	262.0	69.0	-0.389	0.053	1000.0	-1000.0	-0.041	-1000.0
PLK1 signaling events	3.0	329.0	85.0	-0.006	0.054	1000.0	-1000.0	-0.036	-1000.0
Class I PI3K signaling events mediated by Akt	3.0	247.0	68.0	-0.019	0.055	1000.0	-1000.0	-0.039	-1000.0
IL1-mediated signaling events	3.0	193.0	62.0	-0.103	0.072	1000.0	-1000.0	-0.057	-1000.0
S1P5 pathway	3.0	64.0	17.0	-0.013	0.027	1000.0	-1000.0	-0.019	-1000.0
Canonical Wnt signaling pathway	3.0	201.0	51.0	-0.145	0.074	1000.0	-1000.0	-0.055	-1000.0
Wnt signaling	3.0	25.0	7.0	-0.001	0.027	1000.0	-1000.0	-0.023	-1000.0
LPA receptor mediated events	3.0	344.0	102.0	-0.08	0.06	1000.0	-1000.0	-0.062	-1000.0
IGF1 pathway	3.0	205.0	57.0	-0.018	0.062	1000.0	-1000.0	-0.05	-1000.0
S1P4 pathway	3.0	92.0	25.0	-0.011	0.053	1000.0	-1000.0	-0.031	-1000.0
IL12-mediated signaling events	2.0	215.0	87.0	-0.184	0.06	1000.0	-1000.0	-0.078	-1000.0
BARD1 signaling events	2.0	141.0	57.0	-0.046	0.057	1000.0	-1000.0	-0.047	-1000.0
EPO signaling pathway	2.0	135.0	55.0	-0.007	0.074	1000.0	-1000.0	-0.05	-1000.0
mTOR signaling pathway	2.0	140.0	53.0	-0.017	0.047	1000.0	-1000.0	-0.038	-1000.0
Nectin adhesion pathway	2.0	179.0	63.0	-0.026	0.053	1000.0	-1000.0	-0.043	-1000.0
HIF-2-alpha transcription factor network	2.0	108.0	43.0	-0.168	0.094	1000.0	-1000.0	-0.05	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	241.0	83.0	-0.237	0.047	1000.0	-1000.0	-0.049	-1000.0
FAS signaling pathway (CD95)	2.0	111.0	47.0	-0.112	0.04	1000.0	-1000.0	-0.037	-1000.0
Class I PI3K signaling events	2.0	159.0	73.0	-0.02	0.046	1000.0	-1000.0	-0.054	-1000.0
VEGFR1 specific signals	2.0	112.0	56.0	-0.015	0.06	1000.0	-1000.0	-0.057	-1000.0
FOXM1 transcription factor network	2.0	102.0	51.0	-0.092	0.047	1000.0	-1000.0	-0.106	-1000.0
Aurora B signaling	2.0	198.0	67.0	-0.238	0.049	1000.0	-1000.0	-0.045	-1000.0
Signaling events mediated by HDAC Class II	1.0	101.0	75.0	-0.083	0.069	1000.0	-1000.0	-0.036	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	120.0	65.0	-0.011	0.065	1000.0	-1000.0	-0.046	-1000.0
Arf6 downstream pathway	1.0	71.0	43.0	-0.042	0.043	1000.0	-1000.0	-0.04	-1000.0
Insulin-mediated glucose transport	1.0	43.0	32.0	-0.019	0.048	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by HDAC Class I	1.0	107.0	104.0	-0.083	0.066	1000.0	-1000.0	-0.035	-1000.0
Retinoic acid receptors-mediated signaling	1.0	85.0	58.0	-0.031	0.059	1000.0	-1000.0	-0.05	-1000.0
IL2 signaling events mediated by PI3K	1.0	108.0	58.0	-0.016	0.062	1000.0	-1000.0	-0.045	-1000.0
TCGA08_retinoblastoma	1.0	9.0	8.0	-0.048	0.031	1000.0	-1000.0	-0.007	-1000.0
Insulin Pathway	1.0	134.0	74.0	-0.023	0.07	1000.0	-1000.0	-0.054	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	54.0	33.0	-0.049	0.066	1000.0	-1000.0	-0.036	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	15.0	23.0	-0.013	0.048	1000.0	-1000.0	-0.034	-1000.0
Canonical NF-kappaB pathway	0.0	16.0	39.0	-0.0	0.059	1000.0	-1000.0	-0.043	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	0.009	0.026	1000.0	-1000.0	-0.016	-1000.0
Visual signal transduction: Cones	0.0	24.0	38.0	-0.015	0.054	1000.0	-1000.0	-0.02	-1000.0
Circadian rhythm pathway	0.0	5.0	22.0	-0.009	0.057	1000.0	-1000.0	-0.034	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	13.0	17.0	0.016	0.045	1000.0	-1000.0	-0.041	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.027	0.04	1000.0	-1000.0	-0.0	-1000.0
Aurora A signaling	0.0	19.0	60.0	-0.012	0.061	1000.0	-1000.0	-0.03	-1000.0
Aurora C signaling	0.0	0.0	7.0	-0.016	0.028	1000.0	-1000.0	-0.015	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	4.0	37.0	-0.009	0.063	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by HDAC Class III	0.0	17.0	40.0	-0.048	0.05	1000.0	-1000.0	-0.021	-1000.0
TRAIL signaling pathway	0.0	7.0	48.0	-0.0	0.071	1000.0	-1000.0	-0.041	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	0.0	36.0	-0.053	0.056	1000.0	-1000.0	-0.043	-1000.0
Atypical NF-kappaB pathway	0.0	9.0	31.0	-0.0	0.04	1000.0	-1000.0	-0.03	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.0	43.0	45.0	0.0	0.077	1000.0	-1000.0	-0.06	-1000.0
Glypican 2 network	0.0	0.0	4.0	-0.003	0.001	1000.0	-1000.0	0.003	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	1.0	27.0	-0.0	0.062	1000.0	-1000.0	-0.037	-1000.0
IL2 signaling events mediated by STAT5	0.0	11.0	22.0	-0.0	0.04	1000.0	-1000.0	-0.048	-1000.0
Rapid glucocorticoid signaling	0.0	8.0	20.0	-0.003	0.034	1000.0	-1000.0	-0.005	-1000.0
p38 MAPK signaling pathway	0.0	31.0	44.0	-0.0	0.053	1000.0	-1000.0	-0.041	-1000.0
Arf1 pathway	0.0	20.0	54.0	-0.001	0.048	1000.0	-1000.0	-0.019	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.074	1000.0	-1000.0	-0.002	-1000.0
Total	1084	69879	7203	-23.8619835082	7.82447716725	131000	-131000	-5.82383804947	-131000