Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.053 0.091 -9999.0 0.0 -0.204 4.0 4.0 epithelial cell differentiation 0.007 0.107 -9999.0 0.0 -0.205 3.0 3.0 CYFIP2 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.052 0.204 0.693 1.0 -9999.0 0.0 1.0 EGFR -0.037 0.127 -9999.0 0.0 -0.279 3.0 3.0 EPHA2 0.028 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.048 0.128 0.331 1.0 -9999.0 0.0 1.0 CTNNB1 -0.044 0.152 -9999.0 0.0 -0.36 3.0 3.0 ABI1/Sra1/Nap1 0.058 0.024 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.045 0.071 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.032 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.048 0.127 0.329 1.0 -9999.0 0.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.047 0.127 0.329 1.0 -9999.0 0.0 1.0 EGF -0.022 0.104 -9999.0 0.0 -0.177 4.0 4.0 NCKAP1 0.022 0.036 -9999.0 0.0 -0.115 1.0 1.0 AQP3 -0.08 0.154 -9999.0 0.0 -0.466 2.0 2.0 cortical microtubule organization 0.007 0.107 -9999.0 0.0 -0.205 3.0 3.0 GO:0000145 -0.047 0.119 0.31 1.0 -9999.0 0.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.011 0.111 -9999.0 0.0 -0.207 3.0 3.0 MLLT4 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.098 0.067 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.028 0.01 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.065 0.051 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.051 0.088 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.032 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.056 0.09 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.071 0.053 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.015 0.101 -9999.0 0.0 -0.197 3.0 3.0 EGFR/EGFR/EGF/EGF -0.106 0.113 -9999.0 0.0 -0.255 5.0 5.0 RhoA/GDP -0.014 0.12 -9999.0 0.0 -0.214 4.0 4.0 actin cytoskeleton organization -0.055 0.122 0.304 1.0 -9999.0 0.0 1.0 IGF-1R heterotetramer 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.02 0.036 -9999.0 0.0 -0.115 1.0 1.0 DIAPH1 0.014 0.146 -9999.0 0.0 -0.544 1.0 1.0 Wnt receptor signaling pathway -0.007 0.107 0.205 3.0 -9999.0 0.0 3.0 RHOA 0.005 0.095 -9999.0 0.0 -0.36 1.0 1.0 RhoA/GTP -0.108 0.078 -9999.0 0.0 -0.239 2.0 2.0 CTNNA1 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.056 0.124 0.307 1.0 -9999.0 0.0 1.0 EFNA1 0.028 0.01 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.075 0.079 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.083 0.067 -9999.0 0.0 -0.21 3.0 3.0 SEC6/SEC8 -0.078 0.078 -9999.0 0.0 -0.219 2.0 2.0 MGAT3 -0.048 0.128 0.331 1.0 -9999.0 0.0 1.0 HGF/MET -0.059 0.066 -9999.0 0.0 -0.211 2.0 2.0 HGF 0.022 0.015 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.053 0.092 -9999.0 0.0 -0.205 4.0 4.0 actin cable formation -0.0 0.231 0.524 2.0 -9999.0 0.0 2.0 KIAA1543 -0.042 0.121 0.312 1.0 -9999.0 0.0 1.0 KIFC3 -0.089 0.072 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.032 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.048 0.127 0.331 1.0 -9999.0 0.0 1.0 NCK1/GIT1 0.044 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.007 0.107 -9999.0 0.0 -0.205 3.0 3.0 EXOC4 0.022 0.015 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.077 0.067 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.049 0.128 0.331 1.0 -9999.0 0.0 1.0 LIMA1 0.005 0.095 -9999.0 0.0 -0.36 1.0 1.0 ABI1 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.054 0.218 0.734 1.0 -9999.0 0.0 1.0 adherens junction assembly -0.043 0.167 0.438 1.0 -9999.0 0.0 1.0 IGF-1R heterotetramer/IGF1 -0.087 0.069 -9999.0 0.0 -0.219 3.0 3.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.044 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.02 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.043 0.129 0.331 1.0 -9999.0 0.0 1.0 mol:GTP 0.053 0.046 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.051 0.114 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.053 0.091 -9999.0 0.0 -0.204 4.0 4.0 regulation of cell-cell adhesion -0.055 0.122 0.304 1.0 -9999.0 0.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.053 0.092 -9999.0 0.0 -0.205 4.0 4.0