Clinical Features	CN_CNMF		METHLYATION_CNMF		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
FLT3	53 (27%)	142	0.00034	0.0425	6.9999e-05	0.00917	2e-05	0.00268	0.00021	0.0267	5e-04	0.062	0.00057999	0.0713
NPM1	52 (27%)	143	9.9999e-06	0.00144	9.9999e-06	0.00144	9.9999e-06	0.00144	9.9999e-06	0.00144	9.9999e-06	0.00144	9.9999e-06	0.00144
DNMT3A	49 (25%)	146	0.53291	1	9.9999e-06	0.00144	0.0246	1	0.00264	0.306	0.00269	0.307	0.00264	0.306
IDH2	20 (10%)	175	0.11305	1	9.9999e-06	0.00144	0.6886	1	0.34393	1	0.74793	1	0.18542	1
IDH1	18 (9%)	177	0.37166	1	0.00193	0.228	0.25653	1	0.25704	1	0.23399	1	0.8051	1
RUNX1	18 (9%)	177	0.37673	1	0.00012	0.0156	0.00191	0.227	4e-05	0.00528	0.00059999	0.0732	0.00118	0.142
TET2	17 (9%)	178	0.38679	1	0.51567	1	0.29336	1	0.5747	1	0.66071	1	0.84518	1
NRAS	15 (8%)	180	0.29963	1	0.88787	1	0.60215	1	0.93856	1	0.81378	1	0.66886	1
WT1	12 (6%)	183	0.45665	1	9.9999e-06	0.00144	0.081109	1	0.36718	1	0.069379	1	0.27285	1
U2AF1	8 (4%)	187	1	1	0.14887	1	0.23199	1	0.2602	1	0.076959	1	0.47066	1
TP53	15 (8%)	180	9.9999e-06	0.00144	2e-05	0.00268	0.00088999	0.108	0.00214	0.25	0.00024	0.0302	0.00013	0.0168
CEBPA	13 (7%)	182	0.62181	1	0.0082099	0.92	0.19936	1	0.00016	0.0205	0.03437	1	0.01029	1
PHF6	6 (3%)	189	1	1	0.084099	1	0.72838	1	0.47288	1	0.72576	1	0.3469	1
KRAS	8 (4%)	187	0.096749	1	0.36477	1	0.32521	1	0.64499	1	0.25515	1	0.68044	1
SMC3	7 (4%)	188	1	1	0.29887	1	0.54901	1	0.44652	1	0.21841	1	0.41501	1
KIT	8 (4%)	187	0.12787	1	0.12783	1	0.3252	1	0.0055599	0.628	0.35832	1	0.19162	1
RAD21	5 (3%)	190	0.49253	1	0.66471	1	0.60594	1	0.18454	1	0.2159	1	0.60682	1
EZH2	3 (2%)	192	0.02965	1	NA	NA	0.25628	1	0.594	1	0.15776	1	0.41571	1
STAG2	6 (3%)	189	0.57995	1	0.33027	1	0.13046	1	0.02609	1	0.68735	1	0.065519	1
PTPN11	9 (5%)	186	0.69694	1	0.38823	1	0.04717	1	0.50609	1	0.098659	1	0.20861	1
ASXL1	5 (3%)	190	0.74654	1	0.21568	1	0.25826	1	0.59077	1	0.16051	1	0.41488	1
SUZ12	3 (2%)	192	0.29817	1	0.33224	1	0.26026	1	0.58939	1	0.19707	1	0.14259	1
PHACTR1	3 (2%)	192	NA	NA	0.32996	1	NA	NA	NA	NA	0.89122	1	0.41483	1
SMC1A	6 (3%)	189	0.77031	1	0.55179	1	0.57476	1	0.24401	1	0.17237	1	0.66122	1
KDM6A	3 (2%)	192	0.55619	1	1	1	NA	NA	NA	NA	0.89067	1	0.78316	1