Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.026 0.132 -9999.0 0.0 -0.384 12.0 12.0 IHH -0.01 0.065 -9999.0 0.0 -0.289 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.018 0.08 -9999.0 0.0 -0.191 23.0 23.0 LRPAP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.018 0.079 0.19 23.0 -9999.0 0.0 23.0 SMO/beta Arrestin2 -0.052 0.145 -9999.0 0.0 -0.402 13.0 13.0 SMO -0.063 0.151 -9999.0 0.0 -0.428 13.0 13.0 AKT1 -0.008 0.073 -9999.0 0.0 -0.216 6.0 6.0 ARRB2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.013 0.037 -9999.0 0.0 -0.322 2.0 2.0 ADRBK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.062 0.149 -9999.0 0.0 -0.421 13.0 13.0 STIL -0.023 0.115 -9999.0 0.0 -0.293 16.0 16.0 DHH N/PTCH2 0.016 0.042 -9999.0 0.0 -0.224 5.0 5.0 DHH N/PTCH1 -0.027 0.127 -9999.0 0.0 -0.314 17.0 17.0 PIK3CA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.01 0.03 -9999.0 0.0 -0.262 2.0 2.0 PTHLH -0.026 0.135 -9999.0 0.0 -0.438 10.0 10.0 determination of left/right symmetry -0.062 0.149 -9999.0 0.0 -0.421 13.0 13.0 PIK3R1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.026 0.134 -9999.0 0.0 -0.435 10.0 10.0 IHH N/Hhip -0.044 0.109 -9999.0 0.0 -0.238 38.0 38.0 DHH N/Hhip -0.029 0.096 -9999.0 0.0 -0.204 38.0 38.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.062 0.149 -9999.0 0.0 -0.421 13.0 13.0 pancreas development -0.054 0.133 -9999.0 0.0 -0.303 37.0 37.0 HHAT 0.003 0.073 -9999.0 0.0 -0.381 6.0 6.0 PI3K 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.041 0.127 -9999.0 0.0 -0.32 29.0 29.0 somite specification -0.062 0.149 -9999.0 0.0 -0.421 13.0 13.0 SHH Np/Cholesterol/PTCH1 -0.027 0.12 -9999.0 0.0 -0.313 16.0 16.0 SHH Np/Cholesterol/PTCH2 0.009 0.052 -9999.0 0.0 -0.189 9.0 9.0 SHH Np/Cholesterol/Megalin 0.001 0.056 -9999.0 0.0 -0.145 20.0 20.0 SHH 0.003 0.059 -9999.0 0.0 -0.217 11.0 11.0 catabolic process -0.037 0.14 -9999.0 0.0 -0.279 40.0 40.0 SMO/Vitamin D3 -0.045 0.13 -9999.0 0.0 -0.359 16.0 16.0 SHH Np/Cholesterol/Hhip -0.025 0.082 -9999.0 0.0 -0.18 28.0 28.0 LRP2 -0.003 0.064 -9999.0 0.0 -0.262 10.0 10.0 receptor-mediated endocytosis -0.037 0.133 -9999.0 0.0 -0.369 15.0 15.0 SHH Np/Cholesterol/BOC 0.01 0.048 -9999.0 0.0 -0.188 7.0 7.0 SHH Np/Cholesterol/CDO -0.01 0.073 -9999.0 0.0 -0.201 16.0 16.0 mesenchymal cell differentiation 0.025 0.082 0.179 28.0 -9999.0 0.0 28.0 mol:Vitamin D3 -0.026 0.121 -9999.0 0.0 -0.313 16.0 16.0 IHH N/PTCH2 0.005 0.053 -9999.0 0.0 -0.241 5.0 5.0 CDON -0.026 0.108 -9999.0 0.0 -0.292 24.0 24.0 IHH N/PTCH1 -0.035 0.142 -9999.0 0.0 -0.28 40.0 40.0 Megalin/LRPAP1 0.011 0.044 -9999.0 0.0 -0.166 10.0 10.0 PTCH2 0.01 0.052 -9999.0 0.0 -0.381 3.0 3.0 SHH Np/Cholesterol 0.003 0.044 -9999.0 0.0 -0.161 11.0 11.0 PTCH1 -0.037 0.141 -9999.0 0.0 -0.28 40.0 40.0 HHIP -0.054 0.133 -9999.0 0.0 -0.304 37.0 37.0