E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.071 0.182 -9999.0 0.0 -0.426 31.0 31.0 KLHL20 -0.022 0.097 0.167 1.0 -0.211 23.0 24.0 CYFIP2 0.026 0.041 -9999.0 0.0 -0.335 2.0 2.0 Rac1/GDP -0.039 0.116 -9999.0 0.0 -0.244 30.0 30.0 ENAH -0.063 0.172 -9999.0 0.0 -0.4 31.0 31.0 AP1M1 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.02 0.094 0.138 2.0 -0.189 28.0 30.0 ABI1/Sra1/Nap1 -0.038 0.06 -9999.0 0.0 -0.161 26.0 26.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.027 0.095 -9999.0 0.0 -0.176 28.0 28.0 RAPGEF1 -0.065 0.146 -9999.0 0.0 -0.344 31.0 31.0 CTNND1 0.024 0.049 -9999.0 0.0 -0.335 3.0 3.0 regulation of calcium-dependent cell-cell adhesion -0.052 0.168 -9999.0 0.0 -0.387 31.0 31.0 CRK -0.063 0.155 -9999.0 0.0 -0.374 29.0 29.0 E-cadherin/gamma catenin/alpha catenin -0.013 0.122 -9999.0 0.0 -0.221 40.0 40.0 alphaE/beta7 Integrin 0.036 0.044 -9999.0 0.0 -0.226 4.0 4.0 IQGAP1 0.029 0.029 -9999.0 0.0 -0.335 1.0 1.0 NCKAP1 -0.001 0.098 -9999.0 0.0 -0.335 13.0 13.0 Rap1/GTP/I-afadin 0.044 0.055 -9999.0 0.0 -0.177 9.0 9.0 DLG1 -0.053 0.16 -9999.0 0.0 -0.385 29.0 29.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.029 0.062 -9999.0 0.0 -0.145 28.0 28.0 MLLT4 0.008 0.083 -9999.0 0.0 -0.335 9.0 9.0 ARF6/GTP/NME1/Tiam1 0.038 0.061 -9999.0 0.0 -0.177 11.0 11.0 PI3K -0.032 0.082 -9999.0 0.0 -0.184 28.0 28.0 ARF6 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.028 0.13 -9999.0 0.0 -0.265 36.0 36.0 TIAM1 0.003 0.091 -9999.0 0.0 -0.335 11.0 11.0 E-cadherin(dimer)/Ca2+ 0.018 0.096 -9999.0 0.0 -0.173 31.0 31.0 AKT1 -0.026 0.049 -9999.0 0.0 -0.147 9.0 9.0 PIK3R1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.032 0.131 -9999.0 0.0 -0.335 26.0 26.0 RhoA/GDP -0.04 0.118 -9999.0 0.0 -0.244 31.0 31.0 actin cytoskeleton organization -0.014 0.075 0.151 3.0 -0.154 23.0 26.0 CDC42/GDP -0.042 0.119 0.269 1.0 -0.244 31.0 32.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.04 0.109 -9999.0 0.0 -0.212 43.0 43.0 ITGB7 0.023 0.056 -9999.0 0.0 -0.335 4.0 4.0 RAC1 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.02 0.103 -9999.0 0.0 -0.186 31.0 31.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.011 0.084 -9999.0 0.0 -0.171 28.0 28.0 mol:GDP -0.06 0.125 -9999.0 0.0 -0.276 32.0 32.0 CDC42/GTP/IQGAP1 0.04 0.021 -9999.0 0.0 -0.194 1.0 1.0 JUP -0.008 0.111 -9999.0 0.0 -0.335 17.0 17.0 p120 catenin/RhoA/GDP -0.037 0.122 -9999.0 0.0 -0.252 30.0 30.0 RAC1/GTP/IQGAP1 0.036 0.022 -9999.0 0.0 -0.168 1.0 1.0 PIP5K1C/AP1M1 0.044 0.014 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.021 0.057 -9999.0 0.0 -0.335 4.0 4.0 positive regulation of S phase of mitotic cell cycle -0.013 0.052 -9999.0 0.0 -0.136 14.0 14.0 NME1 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.063 0.165 -9999.0 0.0 -0.388 31.0 31.0 regulation of cell-cell adhesion -0.024 0.079 -9999.0 0.0 -0.168 28.0 28.0 WASF2 -0.01 0.042 0.082 1.0 -0.093 19.0 20.0 Rap1/GTP -0.023 0.103 0.175 2.0 -0.208 28.0 30.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.01 0.123 -9999.0 0.0 -0.19 41.0 41.0 CCND1 -0.016 0.063 -9999.0 0.0 -0.167 14.0 14.0 VAV2 -0.092 0.218 -9999.0 0.0 -0.458 36.0 36.0 RAP1/GDP -0.028 0.11 0.193 1.0 -0.221 26.0 27.0 adherens junction assembly -0.062 0.161 -9999.0 0.0 -0.376 31.0 31.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.002 0.11 -9999.0 0.0 -0.186 39.0 39.0 E-cadherin/beta catenin -0.027 0.102 -9999.0 0.0 -0.273 24.0 24.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.069 0.166 -9999.0 0.0 -0.386 32.0 32.0 PIK3CA 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.063 0.131 -9999.0 0.0 -0.327 25.0 25.0 E-cadherin/beta catenin/alpha catenin 0.011 0.099 -9999.0 0.0 -0.204 28.0 28.0 ITGAE 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.053 0.172 -9999.0 0.0 -0.395 31.0 31.0