Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.015 0.086 -9999.0 0.0 -0.189 31.0 31.0 epithelial cell differentiation 0.014 0.093 -9999.0 0.0 -0.172 31.0 31.0 CYFIP2 0.026 0.041 -9999.0 0.0 -0.335 2.0 2.0 ENAH -0.044 0.09 0.271 2.0 -0.249 12.0 14.0 EGFR 0.021 0.011 -9999.0 0.0 -9999.0 0.0 0.0 EPHA2 -0.006 0.101 -9999.0 0.0 -0.335 14.0 14.0 MYO6 -0.03 0.087 0.2 6.0 -0.177 32.0 38.0 CTNNB1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.035 0.078 -9999.0 0.0 -0.21 14.0 14.0 AQP5 -0.021 0.078 -9999.0 0.0 -0.331 3.0 3.0 CTNND1 0.024 0.049 -9999.0 0.0 -0.335 3.0 3.0 mol:PI-4-5-P2 -0.025 0.072 0.205 5.0 -0.161 27.0 32.0 regulation of calcium-dependent cell-cell adhesion -0.039 0.097 0.198 4.0 -0.218 30.0 34.0 EGF -0.026 0.125 -9999.0 0.0 -0.335 23.0 23.0 NCKAP1 -0.001 0.098 -9999.0 0.0 -0.335 13.0 13.0 AQP3 -0.018 0.088 -9999.0 0.0 -0.425 3.0 3.0 cortical microtubule organization 0.014 0.093 -9999.0 0.0 -0.172 31.0 31.0 GO:0000145 -0.026 0.068 0.193 5.0 -0.153 27.0 32.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.018 0.096 -9999.0 0.0 -0.173 31.0 31.0 MLLT4 0.008 0.083 -9999.0 0.0 -0.335 9.0 9.0 ARF6/GDP -0.054 0.078 -9999.0 0.0 -0.18 40.0 40.0 ARF6 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.041 0.087 -9999.0 0.0 -0.193 18.0 18.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.021 0.072 0.182 2.0 -0.267 5.0 7.0 PVRL2 0.007 0.087 -9999.0 0.0 -0.335 10.0 10.0 ZYX -0.026 0.073 0.199 4.0 -0.168 27.0 31.0 ARF6/GTP 0.049 0.086 -9999.0 0.0 -0.182 18.0 18.0 CDH1 -0.032 0.131 -9999.0 0.0 -0.335 26.0 26.0 EGFR/EGFR/EGF/EGF -0.021 0.104 -9999.0 0.0 -0.175 48.0 48.0 RhoA/GDP 0.017 0.091 -9999.0 0.0 -0.166 31.0 31.0 actin cytoskeleton organization -0.033 0.087 0.193 6.0 -0.184 29.0 35.0 IGF-1R heterotetramer -0.0 0.102 -9999.0 0.0 -0.335 14.0 14.0 GIT1 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.0 0.102 -9999.0 0.0 -0.335 14.0 14.0 IGF1 0.0 0.098 -9999.0 0.0 -0.335 13.0 13.0 DIAPH1 -0.014 0.204 -9999.0 0.0 -0.56 19.0 19.0 Wnt receptor signaling pathway -0.014 0.093 0.172 31.0 -9999.0 0.0 31.0 RHOA 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.055 0.078 -9999.0 0.0 -0.181 40.0 40.0 CTNNA1 0.021 0.057 -9999.0 0.0 -0.335 4.0 4.0 VCL -0.035 0.086 0.188 5.0 -0.187 29.0 34.0 EFNA1 0.014 0.069 -9999.0 0.0 -0.335 6.0 6.0 LPP -0.029 0.077 0.203 6.0 -0.295 1.0 7.0 Ephrin A1/EPHA2 -0.013 0.111 -9999.0 0.0 -0.188 43.0 43.0 SEC6/SEC8 -0.05 0.077 -9999.0 0.0 -0.178 39.0 39.0 MGAT3 -0.039 0.098 0.2 4.0 -0.221 30.0 34.0 HGF/MET -0.018 0.104 -9999.0 0.0 -0.173 47.0 47.0 HGF -0.024 0.122 -9999.0 0.0 -0.335 22.0 22.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.015 0.087 -9999.0 0.0 -0.19 31.0 31.0 actin cable formation -0.03 0.114 0.391 4.0 -0.248 13.0 17.0 KIAA1543 -0.034 0.07 0.192 2.0 -0.165 29.0 31.0 KIFC3 -0.034 0.085 0.203 4.0 -0.186 31.0 35.0 NCK1 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.025 0.083 0.209 7.0 -0.167 31.0 38.0 NCK1/GIT1 0.044 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.014 0.093 -9999.0 0.0 -0.172 31.0 31.0 EXOC4 0.027 0.012 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.028 0.078 0.191 5.0 -0.167 31.0 36.0 PIP5K1C -0.025 0.073 0.207 5.0 -0.163 27.0 32.0 LIMA1 0.03 0.029 -9999.0 0.0 -0.335 1.0 1.0 ABI1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.03 0.112 0.392 4.0 -0.266 7.0 11.0 adherens junction assembly -0.036 0.127 0.311 3.0 -0.398 10.0 13.0 IGF-1R heterotetramer/IGF1 -0.018 0.112 -9999.0 0.0 -0.182 49.0 49.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.011 0.086 -9999.0 0.0 -0.231 18.0 18.0 MET 0.025 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.033 0.075 0.204 2.0 -0.173 29.0 31.0 mol:GTP 0.039 0.086 -9999.0 0.0 -0.192 18.0 18.0 establishment of epithelial cell apical/basal polarity -0.027 0.117 0.3 9.0 -0.275 7.0 16.0 cortical actin cytoskeleton stabilization -0.015 0.086 -9999.0 0.0 -0.189 31.0 31.0 regulation of cell-cell adhesion -0.033 0.087 0.193 6.0 -0.184 29.0 35.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.015 0.087 -9999.0 0.0 -0.19 31.0 31.0