Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.102 0.293 -9999.0 0.0 -0.717 65.0 65.0 IHH -0.014 0.086 -9999.0 0.0 -0.509 9.0 9.0 SHH Np/Cholesterol/GAS1 -0.069 0.16 -9999.0 0.0 -0.315 143.0 143.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.086 0.148 0.313 143.0 -9999.0 0.0 143.0 SMO/beta Arrestin2 -0.036 0.175 -9999.0 0.0 -0.585 24.0 24.0 SMO -0.046 0.184 -9999.0 0.0 -0.533 37.0 37.0 AKT1 0.002 0.083 -9999.0 0.0 -0.311 6.0 6.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.007 0.062 -9999.0 0.0 -0.558 6.0 6.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.045 0.181 -9999.0 0.0 -0.522 37.0 37.0 STIL -0.093 0.217 -9999.0 0.0 -0.523 74.0 74.0 DHH N/PTCH2 -0.058 0.144 -9999.0 0.0 -0.404 73.0 73.0 DHH N/PTCH1 -0.069 0.193 -9999.0 0.0 -0.535 39.0 39.0 PIK3CA 0.013 0.027 -9999.0 0.0 -0.592 1.0 1.0 DHH -0.046 0.173 -9999.0 0.0 -0.544 55.0 55.0 PTHLH -0.115 0.344 -9999.0 0.0 -0.921 63.0 63.0 determination of left/right symmetry -0.045 0.181 -9999.0 0.0 -0.522 37.0 37.0 PIK3R1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.113 0.339 -9999.0 0.0 -0.906 63.0 63.0 IHH N/Hhip -0.115 0.209 -9999.0 0.0 -0.446 141.0 141.0 DHH N/Hhip -0.146 0.21 -9999.0 0.0 -0.421 178.0 178.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.045 0.181 -9999.0 0.0 -0.522 37.0 37.0 pancreas development -0.139 0.251 -9999.0 0.0 -0.546 140.0 140.0 HHAT -0.006 0.109 -9999.0 0.0 -0.575 18.0 18.0 PI3K -0.001 0.019 -9999.0 0.0 -0.427 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.014 0.117 -9999.0 0.0 -0.501 28.0 28.0 somite specification -0.045 0.181 -9999.0 0.0 -0.522 37.0 37.0 SHH Np/Cholesterol/PTCH1 -0.093 0.214 -9999.0 0.0 -0.521 69.0 69.0 SHH Np/Cholesterol/PTCH2 -0.067 0.157 -9999.0 0.0 -0.31 142.0 142.0 SHH Np/Cholesterol/Megalin -0.167 0.217 -9999.0 0.0 -0.36 257.0 257.0 SHH -0.079 0.188 -9999.0 0.0 -0.406 123.0 123.0 catabolic process -0.047 0.184 -9999.0 0.0 -0.528 35.0 35.0 SMO/Vitamin D3 -0.084 0.216 -9999.0 0.0 -0.525 65.0 65.0 SHH Np/Cholesterol/Hhip -0.139 0.211 -9999.0 0.0 -0.353 223.0 223.0 LRP2 -0.189 0.273 -9999.0 0.0 -0.55 185.0 185.0 receptor-mediated endocytosis -0.179 0.219 -9999.0 0.0 -0.548 100.0 100.0 SHH Np/Cholesterol/BOC -0.057 0.152 -9999.0 0.0 -0.313 126.0 126.0 SHH Np/Cholesterol/CDO -0.075 0.168 -9999.0 0.0 -0.326 148.0 148.0 mesenchymal cell differentiation 0.152 0.198 0.35 223.0 -9999.0 0.0 223.0 mol:Vitamin D3 -0.091 0.215 -9999.0 0.0 -0.521 69.0 69.0 IHH N/PTCH2 -0.011 0.106 -9999.0 0.0 -0.446 25.0 25.0 CDON -0.025 0.145 -9999.0 0.0 -0.557 35.0 35.0 IHH N/PTCH1 -0.047 0.186 -9999.0 0.0 -0.532 35.0 35.0 Megalin/LRPAP1 -0.142 0.19 -9999.0 0.0 -0.393 185.0 185.0 PTCH2 -0.009 0.114 -9999.0 0.0 -0.558 21.0 21.0 SHH Np/Cholesterol -0.075 0.14 -9999.0 0.0 -0.315 123.0 123.0 PTCH1 -0.047 0.185 -9999.0 0.0 -0.531 35.0 35.0 HHIP -0.139 0.251 -9999.0 0.0 -0.547 140.0 140.0