rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(2), ACO1(1), ACSS1(2), IDH1(220), IDH2(12) 5724551 237 235 10 1 210 8 1 17 1 0 <1.00e-15 <1.00e-15 <5.13e-14 2 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(2), ACO1(1), IDH1(220), IDH2(12), IDH3B(1), OGDHL(1), PC(1), PCK1(1), SDHA(3), SDHC(1) 12856133 243 233 15 1 212 12 1 16 2 0 <1.00e-15 <1.00e-15 <5.13e-14 3 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(1), IDH1(220), IDH2(12), IDH3B(1), PC(1), PCK1(1), SDHA(3) 8868606 239 232 11 0 210 12 1 15 1 0 <1.00e-15 <1.00e-15 <5.13e-14 4 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 CDKN2A(1), MDM2(2), PIK3CA(28), PIK3R1(14), POLR1A(1), RB1(3), TBX2(1), TP53(185) 8752049 235 178 126 5 65 65 4 46 50 5 <1.00e-15 <1.00e-15 <5.13e-14 5 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ANAPC2(1), ANAPC7(1), ATR(1), BUB1(1), BUB3(1), CCNA1(2), CCNB1(1), CCNB2(1), CCNB3(1), CCNE2(1), CDC14B(2), CDC16(1), CDC25B(1), CDKN1B(1), CDKN2A(1), CDKN2C(1), CHEK2(1), CREBBP(4), CUL1(1), FZR1(1), HDAC2(3), MCM6(1), MCM7(1), MDM2(2), PLK1(1), PRKDC(3), RB1(3), SKP2(1), SMAD2(1), SMAD3(1), SMC1B(1), TP53(185), WEE1(1), YWHAE(1), YWHAH(1) 58395004 231 167 136 17 69 59 3 51 44 5 3.99e-13 <1.00e-15 <5.13e-14 6 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 EGFR(21), IGF1R(2), POLR2A(1), PRKCA(1), RB1(3), TEP1(2), TERT(1), TP53(185) 12161005 216 167 115 6 71 53 2 49 36 5 <1.00e-15 <1.00e-15 <5.13e-14 7 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 ATR(1), BAI1(1), BAX(1), CCNB1(1), CCNB2(1), CCNB3(1), CCNE2(1), CCNG2(1), CDKN2A(1), CHEK2(1), CYCS(1), DDB2(1), GTSE1(1), MDM2(2), MDM4(1), PTEN(13), RFWD2(2), SESN3(1), SIAH1(1), THBS1(1), TP53(185), TSC2(2), ZMAT3(1) 28129770 222 166 127 9 69 56 2 51 39 5 <1.00e-15 <1.00e-15 <5.13e-14 8 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(4), PML(1), RB1(3), SP100(2), TNF(1), TP53(185) 8197018 196 156 101 6 67 47 2 41 34 5 <1.00e-15 <1.00e-15 <5.13e-14 9 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 BAX(1), CYCS(1), PRKCA(1), TLN1(3), TP53(185) 11792561 191 149 96 4 66 45 2 42 31 5 <1.00e-15 <1.00e-15 <5.13e-14 10 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 EIF2S2(1), NFKBIA(1), TP53(185) 4219956 187 147 92 3 64 45 2 40 31 5 <1.00e-15 <1.00e-15 <5.13e-14 11 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 CDKN1B(1), CDKN2A(1), CFL1(1), MDM2(2), PRB1(2), TP53(185) 3634115 192 147 97 2 64 48 2 41 32 5 <1.00e-15 <1.00e-15 <5.13e-14 12 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 DOCK1(1), FOS(1), HGF(2), MAPK1(1), MAPK8(1), MET(4), PAK1(1), PIK3CA(28), PIK3R1(14), PTEN(13), PTK2B(1), PTPN11(5), RAF1(1), RASA1(2), STAT3(1) 19010561 76 64 61 4 4 29 2 16 25 0 1.08e-05 <1.00e-15 <5.13e-14 13 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(1), IDH1(220), IDH2(12) 3829902 233 232 6 0 209 8 1 15 0 0 2.00e-15 1.11e-15 5.26e-14 14 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(3), BAX(1), MAPK8(1), MDM2(2), TP53(185) 8955790 192 149 97 4 65 47 3 40 32 5 <1.00e-15 1.33e-15 5.63e-14 15 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 CCNA1(2), CCNB1(1), CCNE2(1), CCNG2(1), CDKN1B(1), CDKN2A(1), CDKN2C(1), CREB3(3), MCM6(1), MCM7(1), MDM2(2), MYT1(2), POLE(1), PRIM1(1), RB1(3), RPA1(1), TNXB(4), TP53(185), WEE1(1) 33251409 213 157 118 9 68 51 2 43 44 5 <1.00e-15 1.44e-15 5.63e-14 16 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 MAX(3), SP3(2), TP53(185) 3042518 190 151 94 2 66 46 2 40 31 5 <1.00e-15 1.55e-15 5.63e-14 17 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 CHEK2(1), MAPK8(1), MDM2(2), NFKBIA(1), RAD50(1), RBBP8(1), TP53(185) 12826627 192 148 97 4 64 50 2 40 31 5 <1.00e-15 1.55e-15 5.63e-14 18 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(1), CHD8(2), CREBBP(4), CSNK1A1L(1), CSNK2A1(1), CTNNB1(1), CUL1(1), CXXC4(1), DKK2(2), DVL2(1), FZD10(1), FZD5(1), FZD6(1), FZD7(1), FZD9(1), LRP6(2), MAPK8(1), MAPK9(1), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), NKD2(1), PLCB1(2), PLCB2(3), PLCB4(1), PPP2R2C(1), PPP3R2(1), PRKACG(1), PRKCA(1), PRKCG(1), RAC2(1), ROCK2(1), SENP2(1), SFRP2(1), SIAH1(1), SMAD2(1), SMAD3(1), SOX17(3), TBL1XR1(1), TBL1Y(1), TCF7L2(2), TP53(185), VANGL2(1), WIF1(2), WNT11(2), WNT16(1), WNT2(1), WNT7A(1), WNT8A(1), WNT9B(1) 69826611 251 178 156 20 86 61 2 53 44 5 <1.00e-15 1.89e-15 5.70e-14 19 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATR(1), CCNB1(1), CDC25B(1), CDC34(1), CHEK2(1), MDM2(2), MYT1(2), PRKDC(3), RPS6KA1(1), TP53(185), WEE1(1), YWHAH(1) 17921597 200 149 105 3 66 48 3 43 35 5 <1.00e-15 1.89e-15 5.70e-14 20 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATR(1), CHEK2(1), TP53(185), YWHAH(1) 6876326 188 146 93 2 65 46 2 39 31 5 <1.00e-15 1.89e-15 5.70e-14 21 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 IFNGR2(1), JAK2(1), NFKBIA(1), RB1(3), TNF(1), TP53(185) 7830332 192 152 97 4 64 46 2 39 36 5 <1.00e-15 2.00e-15 5.70e-14 22 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 BAX(1), CYCS(1), FASLG(1), MAP3K1(2), MDM2(2), NFKBIA(1), PARP1(2), PRF1(1), RIPK1(1), TNF(1), TP53(185), TRADD(1) 16136741 199 152 104 8 67 49 2 43 33 5 <1.00e-15 2.11e-15 5.70e-14 23 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 G6PD(2), GGT1(2), GPX2(1), GSS(1), IDH1(220), IDH2(12) 7788577 238 233 11 3 212 9 1 16 0 0 <1.00e-15 2.22e-15 5.70e-14 24 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(1), CTLA4(1), HLA-DRA(1), PIK3CA(28), PIK3R1(14), PTPN11(5) 5513904 50 42 35 2 3 19 2 10 16 0 0.000243 2.22e-15 5.70e-14 25 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATR(1), BRCA2(2), CHEK2(1), FANCC(1), FANCD2(2), FANCE(2), RAD17(1), RAD50(1), RAD9A(1), TP53(185), TREX1(1) 18972653 198 153 103 4 66 50 2 42 33 5 <1.00e-15 2.33e-15 5.74e-14 26 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 BAX(1), MDM2(2), RB1(3), TP53(185) 7794672 191 150 96 2 64 46 2 40 34 5 <1.00e-15 2.55e-15 6.05e-14 27 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 G6PD(2), GGT1(2), GPX2(1), GSS(1), IDH1(220), IDH2(12) 9502584 238 233 11 4 212 9 1 16 0 0 <1.00e-15 2.78e-15 6.33e-14 28 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ATR(1), CCNA1(2), CDKN1B(1), CDKN2A(1), RB1(3), SKP2(1), TP53(185) 12995477 194 150 99 3 65 46 2 41 35 5 <1.00e-15 3.00e-15 6.59e-14 29 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), EGF(3), EGFR(21), FOS(1), MAP3K1(2), MAPK8(1), PIK3CA(28), PIK3R1(14), PLCG1(4), PRKCA(1), RAF1(1), RASA1(2), SHC1(1), SRF(1), STAT3(1) 16164259 82 65 61 5 7 33 2 18 22 0 6.52e-06 3.11e-15 6.60e-14 30 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 EIF4A1(2), EIF4A2(1), EIF4B(1), EIF4G1(3), EIF4G3(3), MKNK1(1), PIK3CA(28), PIK3R1(14), PTEN(13), TSC1(1), TSC2(2) 11906558 69 59 55 2 5 28 2 13 21 0 2.18e-06 3.22e-15 6.61e-14 31 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 CDC25B(1), MYT1(2), RB1(3), TP53(185), WEE1(1), YWHAH(1) 7565506 193 150 98 2 65 45 2 39 37 5 <1.00e-15 3.66e-15 7.25e-14 32 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 GH1(1), GHR(1), IGF1R(2), PIK3CA(28), PIK3R1(14), SHC1(1) 5747747 47 41 33 1 1 20 2 7 17 0 4.55e-05 3.77e-15 7.25e-14 33 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ARPC1B(1), PAK1(1), PDGFRA(7), PIK3CA(28), PIK3R1(14) 5770746 51 41 37 3 1 22 2 6 20 0 0.00116 3.89e-15 7.25e-14 34 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 BAX(1), CASP1(1), CYCS(1), FASLG(1), MAP3K1(2), MDM2(2), NFKBIA(1), PLEKHG5(1), PRF1(1), RIPK1(1), TNF(1), TP53(185), TRADD(1) 24731875 199 150 104 11 68 48 2 43 33 5 1.89e-15 4.44e-15 7.54e-14 35 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 ATF2(1), IL1R1(1), MAP2K5(1), MAP3K1(2), MAP3K10(1), MAP3K12(2), MAP3K13(1), MAP3K4(2), MAP3K5(2), MAPK7(3), MAPK8(1), MAPK9(1), PAPPA(2), SHC1(1), TP53(185) 21715364 206 149 111 7 66 53 2 45 35 5 <1.00e-15 4.44e-15 7.54e-14 36 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 EIF4A1(2), EIF4A2(1), EIF4G1(3), EIF4G3(3), GHR(1), IRS1(2), MAPK1(1), MKNK1(1), PABPC1(2), PIK3CA(28), PIK3R1(14), PRKCA(1), PTEN(13) 12122047 72 62 58 6 7 28 2 12 23 0 0.000462 4.66e-15 7.54e-14 37 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(1), FOS(1), IRS1(2), MAPK8(1), PIK3CA(28), PIK3R1(14), PTPN11(5), RAF1(1), RASA1(2), SHC1(1), SRF(1) 11010504 57 50 42 4 2 23 2 11 19 0 0.000507 4.77e-15 7.54e-14 38 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(1), ANXA1(2), GNAS(3), NOS3(3), NR3C1(1), PIK3CA(28), PIK3R1(14) 7756817 52 43 38 3 6 20 2 6 18 0 0.000476 4.77e-15 7.54e-14 39 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 PIK3CA(28), PIK3R1(14), PLCG1(4), PRKCA(1), SHC1(1) 6705887 48 42 33 3 2 21 2 6 17 0 0.000928 4.77e-15 7.54e-14 40 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 BAX(1), CSF2RB(1), CYCS(1), FASLG(1), IL1R1(1), IRAK3(1), IRAK4(1), NFKBIA(1), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PPP3R2(1), PRKACG(1), PRKAR1A(2), RIPK1(1), TNF(1), TNFRSF10C(1), TP53(185), TRADD(1) 36058709 246 180 137 16 68 68 5 49 51 5 <1.00e-15 5.33e-15 7.82e-14 41 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 MAPK1(1), MAPK7(3), PIK3CA(28), PIK3R1(14), PLCG1(4), RPS6KA1(1), SHC1(1) 8174470 52 45 37 3 1 23 2 8 18 0 0.000357 5.44e-15 7.82e-14 42 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 BUB1(1), BUB3(1), CCNA1(2), CCNB1(1), CCNB2(1), CCNB3(1), CCNE2(1), CDC14B(2), CDC25B(1), CDH1(1), CDKN2A(1), CHEK2(1), HDAC2(3), HDAC4(2), HDAC5(1), HDAC6(2), MCM6(1), MCM7(1), MDM2(2), MPEG1(1), PLK1(1), PRKDC(3), RB1(3), SKP2(1), TP53(185), WEE1(1) 47247509 221 160 126 14 70 55 3 48 40 5 1.99e-14 5.66e-15 7.82e-14 43 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 PIK3CA(28), PIK3R1(14), PLCB1(2), PLCG1(4), PRKCA(1), VAV1(3) 5530117 52 45 37 3 4 21 2 8 17 0 0.000474 5.66e-15 7.82e-14 44 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 CDKN1B(1), MAPK1(1), PIK3CA(28), PIK3R1(14), PTEN(13), SHC1(1) 8325110 58 52 44 3 2 23 2 11 20 0 0.000184 6.00e-15 7.82e-14 45 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(1), FOS(1), MAPK8(1), PIK3CA(28), PIK3R1(14), PLCG1(4), RAF1(1), SHC1(1) 8240797 51 44 36 2 1 24 2 6 18 0 7.35e-05 6.00e-15 7.82e-14 46 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 BAX(1), CAD(2), CASP8AP2(1), DEDD2(1), EGFR(21), FAF1(1), MAP3K1(2), MAP3K5(2), MAPK1(1), MAPK8(1), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), MET(4), NFAT5(2), NFKBIA(1), RIPK1(1), TNFRSF6B(1), TP53(185), TPX2(1) 31319339 231 166 130 7 68 61 2 51 44 5 <1.00e-15 6.11e-15 7.82e-14 47 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(1), FOS(1), IGF1R(2), IRS1(2), MAPK8(1), PIK3CA(28), PIK3R1(14), PTPN11(5), RAF1(1), RASA1(2), SHC1(1), SRF(1) 10702541 59 52 44 4 2 24 2 11 20 0 0.000302 6.11e-15 7.82e-14 48 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 MAP2K3(1), MAP2K6(1), MAP3K1(2), MAPK1(1), PIK3CA(28), PIK3R1(14), RB1(3) 8379845 50 44 36 3 3 20 2 5 20 0 0.000803 6.22e-15 7.82e-14 49 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 CDKN1B(1), MAPK1(1), NFKBIA(1), PAK1(1), PIK3CA(28), PIK3R1(14), RAF1(1), RB1(3) 8720946 50 43 36 3 1 19 2 5 23 0 0.000831 6.22e-15 7.82e-14 50 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 APC(1), AR(1), BRAF(3), DAG1(1), EGFR(21), GNAI1(3), ITPR1(2), ITPR2(4), ITPR3(4), MAPK1(1), PHKA2(2), PIK3CA(28), PIK3R1(14), PITX2(1), PTX3(1), RAF1(1) 23066937 88 73 68 4 7 33 3 23 22 0 4.43e-07 6.55e-15 8.07e-14 51 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 EIF2S2(1), IGF1R(2), INPPL1(1), PIK3CA(28), PIK3R1(14), PTEN(13) 8469014 59 53 45 2 2 24 2 11 20 0 2.08e-05 7.44e-15 8.81e-14 52 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 IL18(2), KLRC2(1), LAT(1), PAK1(1), PIK3CA(28), PIK3R1(14), PTK2B(1), VAV1(3) 8026572 51 44 37 4 4 21 2 7 17 0 0.00144 7.44e-15 8.81e-14 53 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CFL1(1), LIMK1(3), MAP3K1(2), MYLK(1), NCF2(1), PAK1(1), PDGFRA(7), PIK3CA(28), PIK3R1(14), PLD1(3), TRIO(2), VAV1(3) 15056606 66 54 52 3 8 24 3 9 22 0 1.21e-05 7.88e-15 9.08e-14 54 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(1), BAX(1), CSF2RB(1), IGF1R(2), KIT(2), PIK3CA(28), PIK3R1(14), PRKACG(1), PRKAR1A(2), YWHAH(1) 9466371 53 45 39 3 3 19 2 8 21 0 0.000466 7.99e-15 9.08e-14 55 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 GH1(1), GHR(1), NFKBIA(1), PIK3CA(28), PIK3R1(14), YWHAH(1) 6072506 46 40 32 2 1 19 2 6 18 0 0.000424 8.10e-15 9.08e-14 56 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 MAPK1(1), PDK1(2), PIK3CA(28), PTEN(13), PTK2B(1), SHC1(1) 8790153 46 42 34 3 1 19 2 13 11 0 0.000732 1.07e-13 1.17e-12 57 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 NOTCH1(33) 4064585 33 29 27 2 1 6 0 8 16 2 0.0719 1.99e-13 2.15e-12 58 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 IGF1R(2), IRS1(2), MAPK1(1), PIK3CA(28), PIK3R1(14), RAF1(1), SHC1(1), YWHAH(1) 8175396 50 43 36 4 2 21 2 6 19 0 0.00149 2.23e-13 2.37e-12 59 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 H2AFX(1), PIK3CA(28), PIK3R1(14), RAF1(1), RALA(1), RALGDS(2) 8237438 47 39 33 3 2 19 2 5 19 0 0.00111 3.21e-13 3.35e-12 60 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(1), FOS(1), JAK2(1), PIK3CA(28), PIK3R1(14), PLCG1(4), PRKCA(1), RAF1(1), RASA1(2), SHC1(1), STAT3(1), STAT5B(1) 12904232 56 47 41 3 3 23 2 8 20 0 0.000178 7.02e-13 7.21e-12 61 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(3), EGFR(21), ERBB2(1), ERBB4(1), ETS1(1), ETV6(2), FMN2(2), KRAS(1), MAPK1(1), NOTCH1(33), NOTCH2(5), NOTCH3(4), NOTCH4(5), PIWIL2(2), PIWIL3(1), RAF1(1), SOS2(1), SPIRE1(1) 22668639 86 73 74 6 13 20 1 25 24 3 5.59e-05 7.42e-13 7.49e-12 62 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 MUSK(3), PIK3CA(28), PIK3R1(14), PTK2B(1), TERT(1), YWHAH(1) 7068622 48 41 34 5 2 20 2 6 18 0 0.00729 1.02e-11 1.01e-10 63 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 BCR(1), FOS(1), JAK2(1), MAP3K1(2), MAPK8(1), PIK3CA(28), PIK3R1(14), RAF1(1), STAT5B(1) 12110220 50 42 36 3 2 22 2 6 18 0 0.000360 7.08e-11 6.92e-10 64 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 CABIN1(2), HDAC5(1), IGF1R(2), MAP2K6(1), MAPK7(3), NFATC1(1), NFATC2(2), PIK3CA(28), PIK3R1(14), YWHAH(1) 15025293 55 47 41 3 3 21 3 7 21 0 0.000128 5.79e-10 5.57e-09 65 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), FOS(1), MAP3K1(2), MAPK8(1), PDGFA(1), PDGFRA(7), PIK3CA(28), PIK3R1(14), PLCG1(4), PRKCA(1), RAF1(1), RASA1(2), SHC1(1), SRF(1), STAT3(1) 15059600 66 53 51 6 5 28 2 8 23 0 0.000780 1.00e-09 9.48e-09 66 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(3), EGFR(21), ERBB3(1), NRG1(1) 4441966 26 22 20 0 4 8 0 11 3 0 0.000929 6.12e-09 5.71e-08 67 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(1), EGF(3), EGFR(21), HGS(2), TFRC(2) 5518510 29 24 23 1 5 9 0 12 3 0 0.00221 6.44e-09 5.92e-08 68 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 EGF(3), EGFR(21), MET(4), PDGFRA(7), PRKCA(1), SH3KBP1(1) 8370159 37 30 31 2 4 12 0 14 7 0 0.00193 1.19e-08 1.07e-07 69 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAPK1(1), MAPK12(1), MAPK8(1), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), MAPKAPK5(2), NFKBIA(1), PIK3CA(28), PIK3R1(14) 14546889 51 44 37 3 2 21 2 8 18 0 0.000312 1.43e-08 1.27e-07 70 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 PIK3CA(28), SHC1(1) 6986876 29 26 17 1 0 13 2 6 8 0 0.00118 1.77e-08 1.56e-07 71 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 CALR(1), CREBBP(4), F2(3), GATA4(1), MAPK1(1), MAPK8(1), MYH2(9), NFATC1(1), NFATC2(2), NFATC4(1), PIK3CA(28), PIK3R1(14), PRKACG(1), PRKAR1A(2), RAF1(1) 21898046 70 58 56 5 11 24 2 12 21 0 3.78e-05 2.05e-08 1.77e-07 72 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 CDKN2A(1), PDK1(2), PIK3CA(28), PTEN(13), RPS6KA1(1), RPS6KA3(1), SHC1(1), SOS2(1), TEC(1), YWHAE(1), YWHAH(1) 15499559 51 47 39 4 1 17 2 19 12 0 0.00219 3.75e-08 3.21e-07 73 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(1), GHR(1), IRS1(2), JAK2(1), MAPK1(1), PIK3CA(28), PIK3R1(14), PLCG1(4), PRKCA(1), RAF1(1), RPS6KA1(1), SHC1(1), SRF(1), STAT5B(1) 14257511 58 50 43 6 3 24 2 9 20 0 0.00253 4.93e-08 4.16e-07 74 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(1), GNAI1(3), MAPK1(1), PDGFA(1), PDGFRA(7), PIK3CA(28), PIK3R1(14), PLCB1(2), PRKCA(1), SMPD2(1) 11827152 59 46 45 7 5 23 2 9 20 0 0.00685 5.05e-08 4.20e-07 75 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 BRAF(3), CREB3(3), CREBBP(4), DAG1(1), MAP1B(2), MAPK1(1), MAPK8(1), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), PIK3CA(28), PIK3R1(14), PTPN11(5), RPS6KA3(1), SHC1(1), TH(1) 22225947 68 58 53 5 3 26 2 16 21 0 0.000270 1.25e-07 1.02e-06 76 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(1), F2(3), GNAI1(3), PIK3CA(28), PIK3R1(14), PLCB1(2), PRKCA(1), PTK2B(1) 11151433 53 43 39 6 3 21 2 9 18 0 0.00693 1.83e-07 1.49e-06 77 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(4), IL7R(1), JAK3(1), PIK3CA(28), PIK3R1(14), PTK2B(1), STAT5B(1) 12081469 50 42 36 5 2 20 2 9 17 0 0.00615 1.86e-07 1.49e-06 78 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 CXCR4(1), GNAI1(3), MAPK1(1), PIK3CA(28), PIK3R1(14), PLCG1(4), PRKCA(1), PTK2B(1), RAF1(1) 11926081 54 46 39 6 2 24 3 6 19 0 0.00400 1.89e-07 1.49e-06 79 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 BRD4(1), CDKN2A(1), FLOT1(1), FLOT2(2), INPPL1(1), IRS1(2), IRS4(2), MAPK1(1), PDK1(2), PIK3CA(28), PIK3R1(14), PPYR1(1), PTEN(13), RAF1(1), RPS6KA1(1), RPS6KA3(1), SHC1(1), SOS2(1), YWHAE(1), YWHAH(1) 25706020 76 65 62 6 5 27 2 20 22 0 0.000155 2.40e-07 1.87e-06 80 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(1), GNAS(3), MAPK1(1), PIK3CA(28), PIK3R1(14), PRKACG(1), PRKAR1A(2), PRKCA(1), RPS6KA1(1) 12570769 52 44 38 6 5 19 2 8 18 0 0.0161 3.90e-07 3.00e-06 81 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 DIAPH1(2), MAPK1(1), MYLK(1), PIK3CA(28), PIK3R1(14), RAF1(1), SHC1(1), TLN1(3) 16070441 51 44 37 4 4 19 2 9 17 0 0.00161 6.94e-07 5.28e-06 82 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 FOS(1), LAT(1), MAP3K1(2), MAPK8(1), NFATC1(1), NFATC2(2), NFATC4(1), NFKBIA(1), PIK3CA(28), PIK3R1(14), PLCG1(4), PRKCA(1), RAF1(1), RASA1(2), SHC1(1), VAV1(3), ZAP70(2) 20628598 66 56 51 6 8 26 2 9 21 0 0.000277 9.17e-07 6.89e-06 83 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 FOS(1), MAP3K1(2), MAPK1(1), MAPK8(1), NFATC1(1), NFATC2(2), NFATC4(1), PIK3CA(28), PIK3R1(14), PLA2G4A(4), PLCG1(4), RAF1(1), SHC1(1), VAV1(3) 18566232 64 53 49 6 6 27 2 10 19 0 0.000493 1.02e-06 7.57e-06 84 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 APC(1), CTNNB1(1), GJA1(1), GNAI1(3), LBP(1), PIK3CA(28), PIK3R1(14), TOLLIP(1) 13275021 50 43 36 5 2 19 2 8 19 0 0.00808 1.17e-06 8.57e-06 85 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 EIF2B4(1), EIF2S2(1), FLT4(1), KDR(4), NOS3(3), PIK3CA(28), PIK3R1(14), PLCG1(4), PRKCA(1), SHC1(1) 14673083 58 49 43 8 7 23 2 8 18 0 0.00885 3.56e-06 2.58e-05 86 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(3), EGFR(21), MAP3K1(2), NCOR2(3), RXRA(1), THRA(1) 7476117 31 27 25 3 6 10 0 11 4 0 0.0141 4.75e-06 3.40e-05 87 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 IDH2(12), SDHA(3) 4047423 15 15 5 0 1 9 1 4 0 0 0.00567 5.47e-06 3.87e-05 88 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(1), CTNNB1(1), NOTCH1(33) 9301935 35 31 29 4 1 6 0 9 17 2 0.256 6.69e-06 4.68e-05 89 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 BCR(1), CDKN2A(1), FLOT1(1), FLOT2(2), ITPR1(2), ITPR2(4), ITPR3(4), PDK1(2), PIK3CA(28), PITX2(1), PLCG2(4), PREX1(2), PTEN(13), PTPRC(3), RPS6KA1(1), RPS6KA3(1), SAG(1), TEC(1), VAV1(3) 23813931 75 64 63 9 13 24 3 24 11 0 0.000811 1.01e-05 7.02e-05 90 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ANGPTL2(1), DAG1(1), DGKA(1), ITPR1(2), ITPR2(4), ITPR3(4), MAPK1(1), PAK1(1), PDE3A(1), PI3(1), PIK3CA(28), PIK3R1(14), RPS4X(1) 20992975 60 52 46 6 3 26 3 11 17 0 0.00158 1.28e-05 8.79e-05 91 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 CISH(1), IL13RA1(1), IL4R(1), JAK2(1), JAK3(1), PI3(1), PIK3CA(28), SHC1(1), SOS2(1), STAT6(2), TYK2(2) 15931726 40 35 28 2 3 13 3 10 11 0 0.000489 3.99e-05 0.000270 92 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 AGTR2(1), EGF(3), EGFR(21), FOS(1), PLCG1(4), PRKCA(1) 8845531 31 25 24 3 5 12 0 11 3 0 0.0112 4.39e-05 0.000294 93 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP4B(1), INPPL1(1), OCRL(2), PIK3C2B(1), PIK3CA(28), PIK3CG(2), PLCB1(2), PLCB2(3), PLCB4(1), PLCG1(4), PLCG2(4) 19290465 49 43 36 4 7 20 3 10 9 0 0.000502 6.30e-05 0.000417 94 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 EGF(3), EGFR(21), MAPK1(1), PTPRB(2), RAF1(1), RASA1(2), SHC1(1), SPRY2(1), SPRY4(1) 10745329 33 26 27 3 3 10 0 13 7 0 0.0111 0.000217 0.00142 95 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(1), INPP4B(1), INPPL1(1), ISYNA1(1), OCRL(2), PI4KA(2), PI4KB(2), PIK3CA(28), PIK3CG(2), PIP4K2B(1), PIP4K2C(2), PLCB1(2), PLCB2(3), PLCB4(1), PLCD3(2), PLCE1(3), PLCG1(4), PLCG2(4), PLCZ1(1), PTEN(13), PTPMT1(1), SYNJ1(1), SYNJ2(3) 32059650 81 67 68 8 11 29 3 18 20 0 0.000173 0.000239 0.00155 96 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 BRAF(3), EIF4B(1), MAPK1(1), PGF(1), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PRKAA1(1), RPS6KA1(1), RPS6KA3(1), RPS6KA6(1), TSC1(1), TSC2(2), ULK2(1), VEGFB(2), VEGFC(2) 22963416 63 51 48 6 4 23 5 14 17 0 0.000966 0.000266 0.00171 97 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 IL4R(1), IRS1(2), JAK3(1), MAPK1(1), PDK1(2), PIK3CA(28), PIK3R1(14), RAF1(1), SHC1(1), SOS2(1), STAT6(2) 15780463 54 45 40 8 3 20 2 11 18 0 0.0231 0.000306 0.00194 98 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 GAB2(1), KRAS(1), LAT(1), MAP2K3(1), MAP2K6(1), MAPK1(1), MAPK12(1), MAPK8(1), MAPK9(1), NRAS(1), PDK1(2), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PLCG1(4), PLCG2(4), PRKCA(1), RAC2(1), RAF1(1), SOS2(1), TNF(1), VAV1(3), VAV3(8) 31114900 88 75 66 10 12 31 3 14 28 0 0.000660 0.000345 0.00217 99 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 BCR(1), DAG1(1), MAPK1(1), NFAT5(2), NFKBIA(1), PI3(1), PIK3CA(28), PIK3R1(14), PLCG2(4), RAF1(1), SHC1(1), SOS2(1), VAV1(3) 22738490 59 51 45 6 6 22 2 10 19 0 0.00135 0.000609 0.00379 100 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 CDKN1B(1), CDKN2A(1), CREB3(3), ERBB4(1), INPPL1(1), IRS1(2), IRS4(2), MET(4), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PDK1(2), PIK3CA(28), PREX1(2), PTEN(13), RPS6KA1(1), RPS6KA3(1), SHC1(1), SOS2(1), TSC1(1), TSC2(2), YWHAE(1), YWHAH(1) 33331941 73 66 61 7 4 23 2 26 18 0 0.000512 0.000617 0.00380 101 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(3), GABRA3(2), GABRA4(3), GABRA5(1), GABRA6(3) 3395416 12 12 12 2 5 3 0 4 0 0 0.209 0.000717 0.00437 102 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(5) 870909 5 5 5 0 3 1 0 0 1 0 0.266 0.00151 0.00911 103 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ANGPTL2(1), CFL1(1), GDI1(2), INPPL1(1), ITPR1(2), ITPR2(4), ITPR3(4), LIMK1(3), MYLK(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PDK1(2), PIK3CA(28), PIK3CG(2), PIK3R1(14), PITX2(1), PTEN(13), ROCK2(1), RPS4X(1), SAG(1) 30207956 86 72 72 12 8 32 4 21 21 0 0.00271 0.00265 0.0159 104 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 BRAF(3), DAG1(1), EGFR(21), ITPR1(2), ITPR2(4), ITPR3(4), MAPK1(1), PI3(1), PITX2(1), PLCB1(2), PLCB2(3), PLCB4(1), RAF1(1), SHC1(1), SOS2(1), STAT3(1) 25233789 48 43 42 3 8 15 1 20 4 0 0.000365 0.00481 0.0284 105 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 FOS(1), IL2RB(2), IRS1(2), JAK3(1), MAPK1(1), PIK3CA(28), PIK3R1(14), RAF1(1), SHC1(1), STAT5B(1) 15614863 52 43 38 9 2 22 2 9 17 0 0.0467 0.00483 0.0284 106 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1C(1), ARRB2(1), ATF2(1), BRAF(3), CACNA1A(2), CACNA1B(4), CACNA1D(1), CACNA1E(6), CACNA1F(3), CACNA1G(1), CACNA1H(2), CACNA1I(1), CACNA1S(5), CACNA2D3(1), CACNA2D4(1), CACNB2(1), CACNB3(1), CACNG3(3), CACNG7(1), CACNG8(1), CDC25B(1), DDIT3(1), DUSP16(1), DUSP5(2), EGF(3), EGFR(21), FASLG(1), FGF4(1), FGF5(2), FGF6(1), FGF7(1), FGFR2(1), FGFR4(1), FLNA(3), FLNB(4), FLNC(4), FOS(1), GNG12(1), IL1R1(1), IL1R2(1), KRAS(1), MAP2K3(1), MAP2K5(1), MAP2K6(1), MAP3K1(2), MAP3K10(1), MAP3K12(2), MAP3K13(1), MAP3K4(2), MAP3K5(2), MAP4K4(1), MAPK1(1), MAPK12(1), MAPK7(3), MAPK8(1), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), MAPKAPK5(2), MAX(3), MKNK1(1), NF1(20), NFATC2(2), NFATC4(1), NR4A1(1), NRAS(1), PAK1(1), PDGFA(1), PDGFRA(7), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PPM1B(1), PPP3R2(1), PRKACG(1), PRKCA(1), PRKCG(1), PTPN5(1), PTPRR(2), RAC2(1), RAF1(1), RASA1(2), RASGRF2(2), RASGRP2(1), RASGRP4(1), RPS6KA1(1), RPS6KA3(1), RPS6KA6(1), RRAS(1), SOS2(1), SRF(1), STK3(1), TAOK1(2), TGFBR1(1), TGFBR2(1), TNF(1), TP53(185) 123530337 376 208 273 59 101 101 5 83 74 12 1.52e-10 0.00623 0.0362 107 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL2(1), BRAF(3), BTC(1), CBLB(1), CBLC(1), CDKN1B(1), EGF(3), EGFR(21), ERBB2(1), ERBB3(1), ERBB4(1), HBEGF(1), KRAS(1), MAPK1(1), MAPK8(1), MAPK9(1), NCK1(1), NRAS(1), NRG1(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PLCG1(4), PLCG2(4), PRKCA(1), PRKCG(1), RAF1(1), SHC1(1), SOS2(1), STAT5B(1) 44459158 106 85 85 11 14 35 3 28 26 0 3.21e-05 0.00792 0.0456 108 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 IDH2(12), IDH3B(1), PC(1), PDHA1(3), PDHA2(2), PDHB(1), PDK1(2), PDK3(1), SDHA(3), SDHC(1) 12217520 27 24 17 3 2 13 1 8 3 0 0.0150 0.00933 0.0532 109 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1), IL12B(1), IL18(2) 1280747 4 4 4 1 1 0 1 2 0 0 0.619 0.0113 0.0639 110 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT2(1), AGPAT3(1), AGPS(1), ENPP2(2), PAFAH1B1(2), PAFAH1B3(1), PAFAH2(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PLD1(3) 9987119 19 18 19 1 3 5 2 7 2 0 0.0323 0.0115 0.0643 111 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACPP(3), ENPP1(1), ENPP3(2), FLAD1(1), TYR(2) 4172365 9 9 9 1 3 3 0 1 2 0 0.206 0.0167 0.0927 112 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPP(4), ALPPL2(2), FPGS(2), SPR(1) 2821312 9 8 9 2 3 2 1 1 2 0 0.429 0.0192 0.105 113 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX3(1), FADS2(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4) 4369144 9 9 9 0 1 3 0 3 2 0 0.0742 0.0193 0.105 114 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(21), GNAS(3), IGF1R(2), MAPK1(1), MKNK1(1), PDGFRA(7), PTPRR(2), RAF1(1), RPS6KA1(1), SHC1(1), STAT3(1) 14280875 41 35 35 6 4 14 0 14 9 0 0.0446 0.0298 0.161 115 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(2), CDC34(1), CUL1(1), RB1(3), SKP2(1) 3677825 8 8 8 0 0 2 0 1 5 0 0.252 0.0318 0.170 116 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 ATF2(1), EGFR(21), MAP3K1(2), MAPK1(1), MAPK8(1), PAK1(1), PRKCA(1), PTK2B(1), RAF1(1), SHC1(1) 14459446 31 27 25 4 4 11 0 11 5 0 0.0375 0.0382 0.203 117 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(1), ANKRD1(1), HBEGF(1), IFRD1(2), IL18(2), IL1R1(1), NR4A3(1) 4628694 9 9 9 1 2 3 0 1 3 0 0.302 0.0449 0.237 118 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F2(3), F5(4), F7(1), FGA(1), FGB(1), FGG(1), PROS1(1) 7048274 12 12 12 1 4 4 0 2 2 0 0.0625 0.0657 0.343 119 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 APOA1(1), CD36(1), CREBBP(4), HSD17B4(2), LPL(1), MAPK1(1), NCOA1(1), NCOR1(3), NCOR2(3), NFKBIA(1), NR1H3(1), PDGFA(1), PIK3CA(28), PIK3R1(14), PRKACG(1), PRKAR1A(2), PRKCA(1), PTGS2(1), RB1(3), RXRA(1), STAT5B(1), TNF(1) 27294864 73 63 59 13 7 27 3 11 25 0 0.0350 0.0697 0.360 120 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BRAF(3), CREB3(3), MAPK1(1), RAF1(1) 4799126 8 8 8 0 0 2 0 2 4 0 0.222 0.0701 0.360 121 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CDKN1B(1), CUL1(1), RB1(3), SKP2(1), UBE2M(1) 3686822 7 7 7 0 0 2 0 1 4 0 0.218 0.0736 0.375 122 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(1), TAT(1), TYR(2) 2028505 4 4 4 1 2 0 1 1 0 0 0.583 0.0786 0.397 123 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACPP(3), ENPP1(1), ENPP3(2), FLAD1(1), MTMR6(1), TYR(2) 6468112 10 10 10 1 3 4 0 1 2 0 0.147 0.0892 0.447 124 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 KDR(4), KRAS(1), MAPK1(1), MAPK12(1), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), NOS3(3), NRAS(1), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PLCG1(4), PLCG2(4), PPP3R2(1), PRKCA(1), PRKCG(1), PTGS2(1), RAC2(1), RAF1(1), SH2D2A(1) 31116714 84 68 69 13 14 31 3 14 22 0 0.00154 0.0952 0.473 125 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 LPO(3), MPO(2), TPO(3), TYR(2) 4164396 10 9 10 2 6 2 0 2 0 0 0.267 0.0968 0.477 126 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 CYP1A2(2), CYP2C19(5), CYP2C8(1), CYP3A4(2), CYP3A7(1), HSD3B7(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4) 10290036 19 18 19 2 7 4 0 5 3 0 0.0693 0.100 0.489 127 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(1), ATP6V0A2(1), ATP6V1C2(1), ATP6V1D(1), EGFR(21), HBEGF(1), JAM2(1), MAPK12(1), MAPK8(1), MAPK9(1), MET(4), NFKBIA(1), PAK1(1), PLCG1(4), PLCG2(4), PTPN11(5), PTPRZ1(4), TCIRG1(1), TJP1(3) 30307130 57 45 49 5 9 19 0 17 12 0 0.000612 0.102 0.493 128 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(1), FHL5(1), FSHR(1), GNAS(3), XPO1(1) 4125185 7 7 7 1 2 1 1 2 1 0 0.468 0.116 0.560 129 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 GABRA1(3), GABRA3(2), GABRA4(3), GABRA5(1), GABRA6(3) 5158397 12 12 12 3 5 3 0 4 0 0 0.384 0.119 0.567 130 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 CYCS(1), SDHA(3), SDHC(1), UQCRC1(1) 2845533 6 5 5 0 2 3 0 1 0 0 0.128 0.120 0.567 131 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(2), PC(1), PDHA1(3), SLC25A1(1) 3999603 7 7 7 1 0 2 0 3 2 0 0.306 0.121 0.569 132 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), NAT2(2), XDH(2) 3425900 6 6 6 0 4 0 0 1 1 0 0.134 0.123 0.573 133 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(1), CHRNA1(2) 1400897 3 3 3 0 1 1 0 0 1 0 0.300 0.125 0.573 134 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1) 3680157 7 7 7 1 5 0 0 0 2 0 0.240 0.126 0.573 135 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 RB1(3), SP3(2) 2857372 5 5 5 1 0 1 0 0 4 0 0.718 0.126 0.573 136 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 LARS(1), PDHA1(3), PDHA2(2), PDHB(1) 4316140 7 7 7 1 0 4 0 2 1 0 0.287 0.130 0.585 137 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 BCR(1), CD22(2), CR2(2), DAG1(1), FLOT1(1), FLOT2(2), ITPR1(2), ITPR2(4), ITPR3(4), MAPK1(1), NFATC1(1), NFATC2(2), PDK1(2), PIK3CA(28), PIK3R1(14), PLCG2(4), PTPRC(3), RAF1(1), SHC1(1), SOS2(1), VAV1(3) 31879911 80 69 66 13 14 27 3 18 18 0 0.00572 0.130 0.585 138 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CDC34(1), CUL1(1), FBXW7(1), RB1(3) 3551777 6 6 6 0 1 1 0 0 4 0 0.301 0.133 0.593 139 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IL12B(1), IL15(1), IL16(3), IL18(2), IL6(1), TNF(1) 4265951 9 9 9 2 2 2 1 3 1 0 0.413 0.134 0.593 140 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(1), GNAS(3), PRKAR1A(2) 2849516 6 6 6 1 3 0 0 2 1 0 0.562 0.144 0.634 141 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(2), ENPP1(1), ENPP3(2), NADSYN1(1), NNMT(1), NT5C(2), NT5E(1) 6271908 10 10 10 2 1 6 1 1 1 0 0.264 0.145 0.634 142 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 CHAT(1), PDHA1(3), PDHA2(2) 3014484 6 6 6 1 0 3 0 1 2 0 0.348 0.152 0.660 143 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(1), COQ5(2) 1732532 3 3 3 0 0 2 0 1 0 0 0.387 0.158 0.680 144 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1) 5706969 12 12 12 3 6 1 0 2 3 0 0.292 0.160 0.686 145 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACPP(3), ALPP(4), ALPPL2(2), CYP3A4(2), CYP3A7(1), DHRS2(1), DHRSX(1), PON1(2) 7756665 16 15 16 3 6 3 0 2 5 0 0.208 0.166 0.707 146 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1) 2424150 5 5 5 2 1 1 0 2 1 0 0.678 0.183 0.774 147 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(2), AGTR2(1), NOS3(3), REN(1) 4301265 7 7 7 1 4 1 0 0 2 0 0.334 0.192 0.803 148 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1) 709762 1 1 1 0 0 0 0 1 0 0 0.818 0.195 0.810 149 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3) 3450254 7 7 7 2 4 1 0 0 2 0 0.427 0.197 0.810 150 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3) 3450254 7 7 7 2 4 1 0 0 2 0 0.427 0.197 0.810 151 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(2), CCNE2(1), CDKN1B(1), CDKN2A(1), PRB1(2) 3867390 7 6 7 0 0 4 0 1 2 0 0.135 0.202 0.819 152 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(4), ACACB(5), ACAT2(1), ACSS1(2), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), LDHA(1), LDHAL6B(1), LDHB(1), PC(1), PCK1(1), PDHA1(3), PDHA2(2), PDHB(1), PKLR(1) 20185247 31 31 31 4 13 9 0 6 3 0 0.0129 0.202 0.819 153 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLUD1(2), GLUD2(1) 1963832 3 3 3 1 0 1 0 2 0 0 0.767 0.204 0.821 154 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 CARD11(3), CBLB(1), CBLC(1), CD28(1), CTLA4(1), FOS(1), KRAS(1), LAT(1), NCK1(1), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), NFKBIA(1), NRAS(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PDK1(2), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PLCG1(4), PPP3R2(1), PRKCQ(1), PTPRC(3), SOS2(1), TEC(1), TNF(1), VAV1(3), VAV3(8), ZAP70(2) 43727805 95 77 73 12 15 31 3 16 30 0 0.000685 0.212 0.849 155 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(1), IDI1(1) 1355720 2 2 2 0 0 1 0 0 1 0 0.661 0.215 0.853 156 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(1), B3GNT5(2), ST3GAL3(1), ST3GAL4(1) 3100421 5 5 5 0 2 2 0 0 1 0 0.130 0.221 0.874 157 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 LPO(3), MPO(2), TPO(3) 3611032 8 7 8 2 5 2 0 1 0 0 0.376 0.223 0.874 158 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(2), ICAM1(1), ITGA4(1), ITGAL(2), ITGB2(1), SELE(3) 5209546 10 10 9 3 6 3 0 0 1 0 0.315 0.229 0.888 159 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(2) 790850 2 2 2 1 1 0 0 1 0 0 0.845 0.229 0.888 160 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(1), NR3C1(1), PPARG(1), RXRA(1), TNF(1) 2499615 5 5 5 2 0 3 0 2 0 0 0.658 0.243 0.936 161 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2), PTGS1(1), PTGS2(1) 2299258 4 4 4 1 3 0 0 1 0 0 0.588 0.246 0.939 162 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(2), CCNB1(1), CDKN1B(1), CDKN2A(1), CDKN2C(1), RB1(3) 6920181 9 9 9 0 0 3 0 1 5 0 0.136 0.247 0.939 163 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 EPHX2(2), HSD3B7(1) 2068630 3 3 3 1 1 0 0 2 0 0 0.731 0.254 0.955 164 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 HGD(2) 955265 2 2 2 1 0 0 0 1 1 0 0.941 0.254 0.955 165 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 EGF(3), EGFR(21), ETS1(1), FOS(1), HOXA7(1), MAP2K3(1), MAP2K6(1), MAP3K1(2), MAP3K5(2), MAPK1(1), MAPK8(1), NFKBIA(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(1), RAF1(1), RIPK1(1), TNF(1) 21177733 43 38 37 7 8 16 1 12 6 0 0.0165 0.265 0.989 166 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(1), FOS(1), IL6(1), IL6ST(2), JAK2(1), JAK3(1), PTPN11(5), RAF1(1), SHC1(1), SRF(1), STAT3(1) 10315618 16 16 15 3 1 4 0 8 3 0 0.290 0.275 1.000 167 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADS(2), ECHS1(1), HADHA(2) 2323924 5 5 5 2 1 1 0 1 2 0 0.642 0.282 1.000 168 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ASL(1), CPS1(2), GLUD1(2) 3364346 5 4 5 1 0 0 0 2 3 0 0.813 0.283 1.000 169 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), HLA-DRA(1) 1022309 2 2 2 0 1 0 0 1 0 0 0.573 0.285 1.000 170 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(1), HDC(2), TH(1) 2613399 4 4 4 1 2 1 0 1 0 0 0.510 0.304 1.000 171 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 HK1(3), PFKL(1), PGK1(1), PKLR(1) 4009994 6 6 6 0 2 3 0 0 1 0 0.0839 0.315 1.000 172 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALML3(1), DGKA(1), DGKD(2), DGKH(1), DGKQ(1), FN3K(1), INPP4B(1), INPPL1(1), ITPR1(2), ITPR2(4), ITPR3(4), OCRL(2), PI4KA(2), PI4KB(2), PIK3C2B(1), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PIP4K2B(1), PIP4K2C(2), PLCB1(2), PLCB2(3), PLCB4(1), PLCD3(2), PLCE1(3), PLCG1(4), PLCG2(4), PLCZ1(1), PRKCA(1), PRKCG(1), PTEN(13), PTPMT1(1), SYNJ1(1), SYNJ2(3) 53729361 114 92 99 16 21 37 4 23 29 0 0.000607 0.332 1.000 173 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 DPYS(2), ENPP1(1), ENPP3(2), ILVBL(1), PANK2(1), PANK4(1), VNN1(1) 7451094 9 9 9 0 2 1 0 1 5 0 0.172 0.332 1.000 174 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(1), CA1(1), CA12(1), CA5A(1), CPS1(2), GLUD1(2), HAL(1) 8183484 9 9 9 1 2 1 1 3 2 0 0.290 0.335 1.000 175 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(1), GLUD1(2) 2380799 3 3 3 1 0 0 0 3 0 0 0.811 0.337 1.000 176 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(1), IDI1(1) 1820386 2 2 2 0 0 1 0 0 1 0 0.660 0.342 1.000 177 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 TAT(1) 1134964 1 1 1 1 0 0 1 0 0 0 0.909 0.354 1.000 178 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(1), EEF1D(2), EIF1AX(4), EIF2AK3(1), EIF2B4(1), EIF2S2(1), EIF4A1(2), EIF4A2(1), EIF4G1(3), EIF4G3(3), GSPT2(2), KIAA0664(5), PABPC1(2) 18921187 28 25 27 4 7 6 2 6 7 0 0.0752 0.355 1.000 179 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 GAD2(1), GGT1(2) 2482497 3 3 3 0 2 1 0 0 0 0 0.290 0.356 1.000 180 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(1), FOS(1), JAK2(1), MAPK8(1), PLCG1(4), RAF1(1), SHC1(1), STAT5B(1) 9265220 11 11 10 1 0 6 0 2 3 0 0.111 0.359 1.000 181 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(4), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), LDHA(1), LDHB(1), PC(1), PCK1(1), PDHA1(3), PDHA2(2), PDHB(1), PKLR(1) 15944748 23 23 23 3 7 9 0 4 3 0 0.0327 0.359 1.000 182 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 CHAT(1), DBH(1), DDC(1), GAD2(1), HDC(2), PAH(1), TH(1) 6224415 8 8 8 1 4 1 0 1 2 0 0.242 0.359 1.000 183 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CXCR4(1), FOS(1), MAPK8(1), PLCG1(4), PRKCA(1), PTK2B(1) 5942948 9 9 8 2 1 6 1 0 1 0 0.303 0.361 1.000 184 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 AGPAT2(1), AGPAT3(1), AGPS(1), CHAT(1), DGKA(1), DGKD(2), DGKH(1), DGKQ(1), GNPAT(1), LGALS13(2), LYPLA1(1), PAFAH1B1(2), PAFAH2(1), PLA2G3(1), PLA2G4A(4), PLCB2(3), PLCG1(4), PLCG2(4) 21556210 32 31 31 4 10 10 1 5 6 0 0.0291 0.362 1.000 185 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 CARD11(3), CD22(2), CR2(2), FOS(1), IFITM1(1), KRAS(1), LILRB3(2), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), NFKBIA(1), NRAS(1), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PLCG2(4), PPP3R2(1), RAC2(1), VAV1(3), VAV3(8) 32059436 82 66 61 15 15 25 3 11 28 0 0.0219 0.363 1.000 186 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(3), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH3B2(1), ALDH7A1(1), CNDP1(1), DDC(1), FTCD(3), HAL(1), HARS(1), HDC(2), PRMT5(2), PRMT8(1), PRPS1(1), PRPS2(1) 17087446 25 25 25 4 14 4 2 2 3 0 0.0373 0.377 1.000 187 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 HLA-DRA(1), IL12B(1), IL15(1), IL6(1), PDGFA(1), TNF(1) 5660428 6 6 6 1 1 2 1 2 0 0 0.361 0.390 1.000 188 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 DPYS(2), ENPP1(1), ENPP3(2), PANK2(1), PANK4(1) 6002900 7 7 7 0 2 1 0 0 4 0 0.247 0.391 1.000 189 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(1), GALNT4(1), GALNT6(1), ST3GAL1(1), ST3GAL4(1), WBSCR17(4) 6220936 9 9 9 2 4 1 1 2 1 0 0.451 0.421 1.000 190 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 FUT8(1), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1) 3403392 4 4 4 1 2 1 1 0 0 0 0.541 0.422 1.000 191 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(1), ADRB2(1), CFTR(3), GNAS(3), PRKACG(1), PRKAR1A(2) 5651014 11 11 11 3 4 3 0 2 2 0 0.577 0.428 1.000 192 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(1), FUT5(1), ST3GAL3(1) 2187968 3 3 3 0 1 1 0 0 1 0 0.425 0.430 1.000 193 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ADCY1(1), CCNB1(1), GNAI1(3), GNAS(3), MAPK1(1), MYT1(2), PRKACG(1), PRKAR1A(2), RPS6KA1(1) 8874125 15 15 15 3 3 3 0 4 5 0 0.426 0.431 1.000 194 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 UXS1(2) 1644272 2 2 2 1 0 1 0 0 1 0 0.900 0.432 1.000 195 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR2(2), PDE1A(1), PDE1B(1), PLCB1(2), PLCB2(3) 4807619 9 9 9 3 3 2 0 2 2 0 0.632 0.453 1.000 196 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(2), CYP4F3(4), GGT1(2), LPO(3), LTA4H(1), MPO(2), PLA2G3(1), PLA2G4A(4), PTGES2(1), PTGS1(1), PTGS2(1), TPO(3) 12053396 25 24 25 5 10 5 0 6 4 0 0.111 0.458 1.000 197 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 CREBBP(4), DTX1(1), DVL2(1), HDAC2(3), MAML1(2), MAML2(2), MFNG(1), NCOR2(3), NCSTN(1), NOTCH1(33), NOTCH2(5), NOTCH3(4), NOTCH4(5), NUMBL(2), RBPJ(4), RBPJL(1) 30030744 72 60 66 14 11 12 1 14 31 3 0.225 0.461 1.000 198 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ANGPTL2(1), ARHGEF6(2), BRAF(3), CDKN2A(1), DOCK1(1), GRB7(1), ITGA10(1), ITGA11(2), ITGA2(1), ITGA4(1), ITGA5(1), ITGA8(1), MAPK1(1), MAPK8(1), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), MYLK(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PIK3CA(28), PKLR(1), PLCG1(4), PLCG2(4), PTEN(13), RAF1(1), RALA(1), ROCK2(1), SHC1(1), SOS2(1), TLN1(3), TLN2(1), WAS(2) 52724720 87 70 74 10 12 27 3 25 20 0 0.000242 0.461 1.000 199 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(1), CDC25B(1), SHH(1), XPO1(1) 3734420 4 4 4 0 1 3 0 0 0 0 0.205 0.464 1.000 200 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 DLG4(1), F2(3), F2RL1(2), MAP2K5(1), MAPK1(1), MAPK7(3), MAPK8(1), PLD1(3), RAF1(1), RASAL1(1), TEC(1), VAV1(3) 11848811 21 19 21 4 5 5 1 6 4 0 0.177 0.471 1.000 201 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(2) 2091986 2 2 2 1 0 2 0 0 0 0 0.739 0.478 1.000 202 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(1), FUCA1(1), FUCA2(2), HEXA(1), LCT(2), MAN2C1(1), NEU1(1), NEU2(2) 7140484 11 11 11 3 3 2 1 3 2 0 0.545 0.483 1.000 203 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 LPO(3), MPO(2), MTHFR(1), TPO(3) 4999800 9 8 9 2 5 2 0 2 0 0 0.341 0.485 1.000 204 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 CREBBP(4), PRF1(1) 4558722 5 5 5 1 2 1 0 1 1 0 0.600 0.485 1.000 205 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(2), APOBEC4(1) 3154212 3 3 3 1 0 1 0 1 1 0 0.703 0.488 1.000 206 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 GNAS(3), PRKACG(1), PRKAR1A(2), PRKCA(1) 4147641 7 7 7 2 3 0 0 2 2 0 0.792 0.498 1.000 207 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(1), DDIT3(1), MAP2K6(1), MAP3K1(2), MAP3K5(2), MAPKAPK5(2), MAX(3), MKNK1(1), PLA2G4A(4), RIPK1(1), SHC1(1), TGFBR1(1), TRADD(1) 15799654 21 20 20 3 4 9 0 5 3 0 0.106 0.503 1.000 208 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 LPO(3), MPO(2), TPO(3) 5090866 8 7 8 2 5 2 0 1 0 0 0.368 0.504 1.000 209 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), HLA-DRA(1) 1711473 2 2 2 0 1 0 0 1 0 0 0.584 0.511 1.000 210 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 MARCKS(1), NFATC1(1), NFATC2(2), NFATC4(1), PLCG1(4), PRKCA(1), SP3(2) 9029438 12 12 11 2 3 4 0 1 4 0 0.264 0.520 1.000 211 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 HLA-DRA(1) 1311478 1 1 1 1 0 0 0 1 0 0 0.945 0.520 1.000 212 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(2), ACE2(1), AGTR2(1), CMA1(1), CTSG(1), ENPEP(4), NLN(1), REN(1), THOP1(1) 9136516 13 13 13 3 4 3 0 3 3 0 0.359 0.524 1.000 213 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT2(1) 1454369 1 1 1 0 0 0 0 1 0 0 0.819 0.532 1.000 214 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 SNCA(1), SNCAIP(1), UBE2G2(1) 2775440 3 3 3 0 3 0 0 0 0 0 0.282 0.533 1.000 215 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GGT1(2) 1793900 2 2 2 0 1 1 0 0 0 0 0.440 0.542 1.000 216 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(4), PRKCA(1), PTK2B(1) 2902475 7 7 6 3 2 4 0 0 1 0 0.636 0.551 1.000 217 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 C1GALT1(1), GALNT1(1), GALNT14(1), GALNT4(1), GALNT5(1), GALNT6(1), GALNTL1(1), GALNTL4(1), GALNTL5(1), OGT(5), ST3GAL1(1), ST6GALNAC1(1), WBSCR17(4) 13919571 20 20 20 4 5 5 1 5 4 0 0.325 0.555 1.000 218 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 UXS1(2) 2097000 2 2 2 1 0 1 0 0 1 0 0.901 0.555 1.000 219 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(1), PLCB1(2) 3080286 3 3 3 1 0 0 0 2 1 0 0.755 0.556 1.000 220 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(1) 912723 1 1 1 0 0 0 0 1 0 0 0.810 0.562 1.000 221 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 CXCL9(1), FOS(1), IFNA21(1), IFNA5(1), IFNAR1(2), IKBKE(2), IL12B(1), IL6(1), IRAK4(1), LBP(1), MAP2K3(1), MAP2K6(1), MAPK1(1), MAPK12(1), MAPK8(1), MAPK9(1), NFKBIA(1), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), RIPK1(1), SPP1(1), TBK1(1), TICAM1(1), TLR1(3), TLR2(1), TLR3(1), TLR5(1), TLR6(2), TLR7(2), TLR9(2), TNF(1), TOLLIP(1) 38698773 82 71 68 15 11 31 4 14 22 0 0.0101 0.562 1.000 222 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 FOS(1), MAPK1(1), MAPK8(1), PRKCA(1) 3834844 4 4 4 1 1 3 0 0 0 0 0.455 0.563 1.000 223 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1) 1686724 1 1 1 0 0 0 0 1 0 0 0.818 0.568 1.000 224 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(1), PRKCA(1) 2138681 2 2 2 1 1 0 0 1 0 0 0.802 0.569 1.000 225 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(2), ICAM1(1), ITGAL(2), ITGB2(1), SELE(3) 4479835 9 9 8 4 6 2 0 0 1 0 0.537 0.570 1.000 226 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(3), LCT(2), PYGL(1) 5792937 6 6 6 1 2 2 0 0 2 0 0.257 0.575 1.000 227 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), MAP3K1(2), MAP3K5(2), MAPK8(1), NFKBIA(1), TNFRSF9(2), TNFSF9(1) 8327115 10 10 10 2 2 4 0 0 4 0 0.396 0.581 1.000 228 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 NR1H3(1), RXRA(1) 2340728 2 2 2 1 0 1 1 0 0 0 0.777 0.581 1.000 229 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), CYP2C19(5), DHRS2(1), DHRSX(1), ECHS1(1), ESCO2(1), HADHA(2) 13301174 19 17 19 3 10 3 0 1 5 0 0.0923 0.583 1.000 230 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG5(3), IFNA21(1), IFNA5(1), PIK3R4(1), PRKAA1(1), ULK2(1) 9096352 8 8 8 1 1 3 0 2 2 0 0.222 0.585 1.000 231 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CFL1(1) 1670598 1 1 1 0 0 0 0 0 1 0 0.659 0.593 1.000 232 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST3A1(1), XYLT1(2) 2861050 3 3 3 0 1 2 0 0 0 0 0.262 0.598 1.000 233 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST3A1(1), XYLT1(2) 2861050 3 3 3 0 1 2 0 0 0 0 0.262 0.598 1.000 234 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(2), ICAM1(1), ITGA4(1), ITGAL(2), ITGB2(1), SELE(3), SELP(1) 6871726 11 11 10 4 6 3 0 1 1 0 0.429 0.605 1.000 235 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(3), CR2(2), HLA-DRA(1), ICAM1(1), ITGAL(2), ITGB2(1), PTPRC(3) 6542998 13 12 13 4 7 2 0 2 2 0 0.373 0.605 1.000 236 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 HLA-DRA(1), PTPRC(3), ZAP70(2) 3895662 6 6 6 2 2 2 0 2 0 0 0.642 0.607 1.000 237 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST3GAL1(1), ST3GAL4(1) 2438625 2 2 2 1 1 0 1 0 0 0 0.859 0.612 1.000 238 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 BRAF(3), CD244(1), FASLG(1), HLA-G(2), ICAM1(1), IFNA21(1), IFNA5(1), IFNAR1(2), IFNGR2(1), ITGAL(2), ITGB2(1), KIR2DL1(3), KLRC2(1), KRAS(1), LAT(1), MAPK1(1), MICA(1), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), NRAS(1), PAK1(1), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PLCG1(4), PLCG2(4), PPP3R2(1), PRF1(1), PRKCA(1), PRKCG(1), PTK2B(1), PTPN11(5), RAC2(1), RAF1(1), SH2D1A(1), SH2D1B(1), SH3BP2(1), SHC1(1), SOS2(1), TNF(1), TNFRSF10C(1), ULBP1(1), VAV1(3), VAV3(8), ZAP70(2) 48882094 118 96 95 24 19 37 3 25 34 0 0.0180 0.613 1.000 239 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSS(1), TNF(1), XDH(2) 4275718 4 4 4 1 2 1 0 0 1 0 0.493 0.615 1.000 240 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 FDPS(1), IDI1(1), MVD(1), NSDHL(2) 5685804 5 5 5 0 2 1 0 1 1 0 0.257 0.620 1.000 241 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 CHPF(1), CHST11(1), CHST13(1), CHSY1(1), DSE(1), XYLT1(2) 6090316 7 7 7 1 3 2 0 2 0 0 0.245 0.621 1.000 242 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(4), MAP2(2), PRKACG(1) 7821214 7 7 7 0 0 2 0 0 5 0 0.332 0.622 1.000 243 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(1), BCR(1), FOS(1), MAP3K1(2), MAPK1(1), MAPK8IP3(1), PAPPA(2), RPS6KA1(1), RPS6KA3(1), SHC1(1), VAV1(3), VAV3(8) 13832475 23 23 16 5 3 4 0 7 9 0 0.655 0.632 1.000 244 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(4), PRKAA1(1) 6227744 5 5 5 1 3 2 0 0 0 0 0.422 0.633 1.000 245 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(1), ACACA(4), ACACB(5), ACAT2(1), ACSS1(2), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH6A1(1), ALDH7A1(1), ECHS1(1), HADHA(2), LDHA(1), LDHAL6B(1), LDHB(1) 17105171 27 26 27 5 13 5 0 6 3 0 0.0834 0.638 1.000 246 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 EGF(3), EGFR(21), MAPK1(1), MYLK(1), PRKACG(1), PRKAR1A(2), TLN1(3) 14118939 32 28 26 8 6 9 0 14 3 0 0.324 0.647 1.000 247 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25B(1), WEE1(1) 2943558 2 2 2 1 1 0 0 0 1 0 0.942 0.653 1.000 248 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 CDC25B(1), MYT1(2), WEE1(1), YWHAH(1) 5927391 5 5 5 0 1 0 0 0 4 0 0.409 0.669 1.000 249 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(3) 3629332 3 3 3 0 1 2 0 0 0 0 0.313 0.674 1.000 250 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 HEXA(1), IDS(1), LCT(2), NAGLU(2) 6232259 6 6 6 1 2 2 0 0 2 0 0.391 0.674 1.000 251 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GGT1(2) 2376239 2 2 2 0 1 1 0 0 0 0 0.449 0.679 1.000 252 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), BAG4(1), CRADD(1), LMNA(1), LMNB2(1), MADD(1), MAP3K1(2), MAPK8(1), PAK1(1), PRKDC(3), RB1(3), RIPK1(1), SPTAN1(2), TNF(1), TRADD(1) 16624676 21 19 21 3 6 5 1 3 6 0 0.125 0.681 1.000 253 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SRP72(1), SRPR(1) 3246178 2 2 2 1 2 0 0 0 0 0 0.815 0.682 1.000 254 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(2), DAG1(1), ITPR1(2), ITPR2(4), ITPR3(4), NFKBIA(1), PDK1(2), PHKA2(2), PITX2(1), PLD1(3) 19345027 22 22 22 3 6 4 2 9 1 0 0.0903 0.682 1.000 255 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 IL6(1), LPL(1) 2295534 2 2 2 0 0 0 0 2 0 0 0.699 0.687 1.000 256 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFS1(1), NDUFV2(1) 3003480 2 2 2 0 0 0 0 1 1 0 0.832 0.689 1.000 257 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 ABAT(1), ACADS(2), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ECHS1(1), GAD2(1), HADHA(2), L2HGDH(1), PDHA1(3), PDHA2(2), PDHB(1) 11125911 22 21 22 6 7 5 0 4 6 0 0.205 0.690 1.000 258 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B4GALNT1(1), HEXA(1), LCT(2), SLC33A1(1), ST3GAL1(1), ST6GALNAC3(1), ST8SIA5(1) 7099090 8 8 8 2 4 0 1 1 2 0 0.597 0.704 1.000 259 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS2(1), PPOX(1) 3284851 2 2 2 1 0 1 0 1 0 0 0.805 0.709 1.000 260 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 LDHA(1), LDHB(1), NCL(1) 3852719 3 3 3 0 0 1 0 1 1 0 0.562 0.710 1.000 261 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 ECHS1(1), HADHA(2) 2085196 3 3 3 3 0 1 0 1 1 0 0.924 0.712 1.000 262 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 LDHA(1), LDHB(1) 2949177 2 2 2 0 0 1 0 1 0 0 0.563 0.714 1.000 263 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP9(1), RECK(1), TIMP4(1) 3249643 3 3 3 1 2 0 0 0 1 0 0.644 0.719 1.000 264 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 HEXA(1), HYAL1(1), IDS(1), LCT(2), NAGLU(2), SPAM1(1) 8863126 8 8 8 1 3 2 0 1 2 0 0.278 0.720 1.000 265 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 P2RY2(1), P2RY6(1) 2572781 2 2 2 1 1 1 0 0 0 0 0.716 0.722 1.000 266 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CD28(1), CTLA4(1), DAG1(1), FBXW7(1), LAT(1), MAPK1(1), NCK1(1), NFAT5(2), NFKBIA(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PLCG1(4), PTPRC(3), RAF1(1), RASGRP2(1), RASGRP4(1), SOS2(1), VAV1(3), ZAP70(2) 24023237 30 26 29 3 9 11 0 4 6 0 0.00813 0.723 1.000 267 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 MST1(3), TNF(1) 2826765 4 4 4 2 1 2 0 0 1 0 0.701 0.725 1.000 268 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(1), CYP11B1(1), HSD3B2(1) 3988391 3 3 3 0 1 0 0 2 0 0 0.478 0.734 1.000 269 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(1), CYP11B1(1), HSD3B2(1) 3988391 3 3 3 0 1 0 0 2 0 0 0.478 0.734 1.000 270 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CREBBP(4), GNAS(3), HLA-DRA(1), PRKACG(1), PRKAR1A(2), PTPRC(3), ZAP70(2) 9917795 17 16 17 4 6 3 0 5 3 0 0.484 0.735 1.000 271 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CREBBP(4), GNAS(3), HLA-DRA(1), PRKACG(1), PRKAR1A(2), PTPRC(3), ZAP70(2) 9917795 17 16 17 4 6 3 0 5 3 0 0.484 0.735 1.000 272 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 LDHA(1), LDHAL6B(1), LDHB(1), SULT1C2(1) 5405420 4 4 4 1 1 1 0 1 1 0 0.676 0.743 1.000 273 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(1), GNAS(3), PRKAA1(1), PRKACG(1), PRKAR1A(2) 6623564 8 8 8 2 4 0 0 2 2 0 0.689 0.744 1.000 274 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(3), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH3B2(1), CNDP1(1), DDC(1), HAL(1), HARS(1), HDC(2), PRPS1(1), PRPS2(1) 10532488 19 18 19 5 11 3 1 2 2 0 0.209 0.745 1.000 275 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 FBP2(1), G6PC(3), HK1(3), HK3(1), LDHA(1), LDHAL6B(1), LDHB(1), PC(1), PCK1(1), PDHA1(3), PDHA2(2), PDHB(1), PFKL(1), PGAM2(1), PGK1(1), PKLR(1) 18321219 23 22 23 3 6 11 0 4 2 0 0.0208 0.746 1.000 276 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1) 1679431 1 1 1 1 0 1 0 0 0 0 0.890 0.751 1.000 277 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD28(1) 1382645 1 1 1 1 1 0 0 0 0 0 0.903 0.753 1.000 278 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(1), COL4A4(1), COL4A5(3), COL4A6(3), F2(3), F5(4), F8(3), FGA(1), FGB(1), FGG(1), KLKB1(3), PROS1(1), SERPING1(2) 19133764 27 26 27 6 10 8 1 3 5 0 0.104 0.762 1.000 279 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(2), PRKACG(1) 4350880 3 3 3 1 0 1 0 1 1 0 0.819 0.765 1.000 280 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), RIPK1(1), TNF(1), TRADD(1) 3632122 4 4 4 2 1 1 0 1 1 0 0.818 0.766 1.000 281 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 HEXA(1), ST3GAL1(1), ST3GAL4(1) 4366757 3 3 3 1 1 0 1 0 1 0 0.792 0.769 1.000 282 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(1), CDC25B(1), PRKCA(1) 3971069 3 3 3 1 2 1 0 0 0 0 0.600 0.773 1.000 283 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADS(2), ACADVL(1), ACSL1(3), ACSL4(1), HADHA(2), PECR(1) 7247921 10 10 10 3 1 3 0 2 4 0 0.578 0.775 1.000 284 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 FARS2(2), PAH(1), TAT(1) 3575269 4 4 4 2 1 1 1 0 1 0 0.812 0.776 1.000 285 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(1), JAK2(1), TYK2(2) 4519814 5 5 5 2 1 0 1 0 3 0 0.716 0.777 1.000 286 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(1), JAK2(1), TYK2(2) 4519814 5 5 5 2 1 0 1 0 3 0 0.716 0.777 1.000 287 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS2(1), DHRSX(1), HSD3B7(1), PON1(2) 3872099 5 5 5 2 1 1 0 1 2 0 0.782 0.780 1.000 288 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 DHRS2(1), DHRSX(1), PRMT5(2), PRMT8(1) 6472756 5 5 5 0 1 3 1 0 0 0 0.140 0.787 1.000 289 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 IARS2(1), ILVBL(1), LARS(1), PDHA1(3), PDHA2(2), PDHB(1) 8019112 9 9 9 2 0 4 0 3 2 0 0.440 0.787 1.000 290 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(4), ACACB(5), FASN(1), OXSM(1) 6885313 11 11 11 4 5 3 0 1 2 0 0.524 0.792 1.000 291 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 FDPS(1), IDI1(1), MVD(1) 4771411 3 3 3 0 0 1 0 1 1 0 0.550 0.796 1.000 292 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 HK1(3), HK3(1), PGM3(1) 4410998 5 5 5 2 0 3 0 1 1 0 0.626 0.798 1.000 293 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 CREB3(3), IL1R1(1), MAP2K3(1), MAP2K6(1), MAP3K10(1), MAP3K4(2), MAP3K5(2), MAPK1(1), MAPK12(1), MAPKAPK5(2), MKNK1(1), SRF(1) 14388816 17 17 17 4 1 7 0 5 4 0 0.496 0.800 1.000 294 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(1) 1627024 1 1 1 0 1 0 0 0 0 0 0.612 0.800 1.000 295 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 RAB27A(1) 1818191 1 1 1 0 1 0 0 0 0 0 0.642 0.802 1.000 296 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 HK1(3), HK3(1), ISYNA1(1), PGM3(1) 5043619 6 6 6 2 0 4 0 1 1 0 0.507 0.802 1.000 297 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 GGT1(2), MARS2(1), SCLY(1) 5336322 4 4 4 1 1 2 1 0 0 0 0.464 0.802 1.000 298 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(2), ATP6V1C2(1), ATP6V1D(1), ATP7A(1), COX7B(1), NDUFS1(1), NDUFV2(1), SDHA(3), UQCRC1(1), UQCRH(1) 16441971 13 13 12 0 4 5 0 3 1 0 0.0172 0.807 1.000 299 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(1), CREB3(3), DAG1(1), FOS(1), MAPK1(1), MAPK8(1), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1) 12366981 11 11 11 0 1 4 0 3 3 0 0.0750 0.807 1.000 300 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CYP11A1(1), HSD3B2(1) 2975165 2 2 2 1 1 0 0 1 0 0 0.875 0.808 1.000 301 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(1), PRKCA(1) 3885763 2 2 2 1 1 0 0 1 0 0 0.823 0.808 1.000 302 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR2(1), JAK2(1) 3515158 2 2 2 2 0 0 0 0 2 0 0.965 0.812 1.000 303 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(3) 2604049 3 3 3 2 2 1 0 0 0 0 0.806 0.812 1.000 304 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(1), ACAD9(1), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), DHRS2(1), DHRSX(1), ESCO2(1) 10743125 10 10 10 2 2 2 0 4 2 0 0.406 0.814 1.000 305 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(2), PAH(1), TAT(1) 3748069 4 4 4 2 1 1 1 0 1 0 0.819 0.815 1.000 306 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(1), CA1(1), CA12(1), CA5A(1), CPS1(2), GLUD1(2), GLUD2(1), HAL(1) 9149707 10 10 10 3 2 2 1 3 2 0 0.580 0.816 1.000 307 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 MAP2K3(1), MAP3K1(2), MAPK1(1), MAPK8(1), PAK1(1), PLCG1(4), PRKCA(1), PTK2B(1), RAF1(1), SHC1(1) 12303490 14 14 13 3 3 7 0 1 3 0 0.249 0.818 1.000 308 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2E1(1), GTF2H4(1), GTF2IRD1(1), TAF1(4), TAF1L(2), TAF2(1), TAF4(1), TAF6(1), TAF9B(1), TBPL2(1) 15500100 14 14 14 2 5 3 0 4 2 0 0.182 0.822 1.000 309 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(1), FOS(1), JAK2(1), RAF1(1), SHC1(1), STAT5B(1) 7612079 6 6 6 1 0 1 0 2 3 0 0.485 0.824 1.000 310 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(1), ADRB2(1), GNAS(3), PLCE1(3), PRKACG(1), PRKAR1A(2), RAP2B(1) 6371572 12 12 12 4 4 2 0 3 3 0 0.763 0.829 1.000 311 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHA4(3), L1CAM(1), SELP(1) 6795425 5 5 5 1 2 1 0 2 0 0 0.538 0.830 1.000 312 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), UBE2G2(1), UBE2M(1) 4537963 3 3 3 1 1 1 0 0 1 0 0.813 0.830 1.000 313 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(2), ANXA2(2), ANXA3(1), ANXA6(1), CYP11A1(1), PLA2G4A(4), PTGS1(1), PTGS2(1) 8878976 13 13 13 4 4 3 1 4 1 0 0.459 0.830 1.000 314 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMPR1B(1) 2711112 1 1 1 2 0 0 0 0 1 0 1.000 0.831 1.000 315 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 DAG1(1) 2626253 1 1 1 0 0 1 0 0 0 0 0.655 0.838 1.000 316 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(1) 2116549 1 1 1 0 1 0 0 0 0 0 0.682 0.843 1.000 317 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), FAF1(1), LMNA(1), LMNB2(1), MAP3K1(2), MAPK8(1), PAK1(1), PRKDC(3), RB1(3), SPTAN1(2) 17421833 16 15 16 2 3 4 1 2 6 0 0.178 0.850 1.000 318 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(2), ALOX12B(1), CYP2B6(1), CYP2C19(5), CYP2C8(1), CYP4A11(1), CYP4A22(1), CYP4F3(4), EPHX2(2), GGT1(2), GPX2(1), LTA4H(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PTGES2(1), PTGS1(1), PTGS2(1) 16802858 32 30 32 7 12 6 0 9 5 0 0.119 0.850 1.000 319 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), ECHS1(1), HADHA(2), HSD17B4(2) 3650855 6 6 6 3 0 2 0 2 2 0 0.836 0.852 1.000 320 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), CACNA1D(1), CACNA1F(3), CACNA1S(5), CALML3(1), EGFR(21), GNAS(3), GNRHR(1), HBEGF(1), ITPR1(2), ITPR2(4), ITPR3(4), KRAS(1), MAP2K3(1), MAP2K6(1), MAP3K1(2), MAP3K4(2), MAPK1(1), MAPK12(1), MAPK7(3), MAPK8(1), MAPK9(1), NRAS(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PLCB1(2), PLCB2(3), PLCB4(1), PLD1(3), PRKACG(1), PRKCA(1), PTK2B(1), RAF1(1), SOS2(1) 54977075 92 74 86 13 24 25 2 27 14 0 0.000490 0.855 1.000 321 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CRADD(1), MAP2K3(1), MAP2K6(1), MAP3K1(2), MAPK8(1), NFKBIA(1), RIPK1(1), TANK(2), TNF(1), TRADD(1) 10446813 12 12 12 3 5 4 0 0 3 0 0.308 0.858 1.000 322 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 PTK2B(1), SHC1(1) 3807867 2 2 2 1 0 1 0 1 0 0 0.813 0.859 1.000 323 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASDHPPT(1) 2035737 1 1 1 0 0 0 0 0 1 0 0.719 0.861 1.000 324 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(1) 2647639 1 1 1 1 0 1 0 0 0 0 0.880 0.865 1.000 325 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR6(1) 2763690 1 1 1 0 0 1 0 0 0 0 0.676 0.869 1.000 326 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT2(1) 3086050 1 1 1 0 0 0 0 1 0 0 0.823 0.871 1.000 327 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 BAX(1), CASP8AP2(1) 4641159 2 2 2 0 0 0 0 0 2 0 0.691 0.871 1.000 328 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 FOS(1), MAP2K3(1), MAP2K6(1), MAP3K1(2), MAPK8(1), NFKBIA(1), TLR10(1), TLR2(1), TLR3(1), TLR6(2), TLR7(2), TLR9(2), TOLLIP(1) 15759099 17 17 17 4 7 4 0 3 3 0 0.272 0.873 1.000 329 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1B(1), ADRB2(1), CHRM1(1), CHRM3(3), CHRM5(1), DRD5(3), HRH1(1), HTR1B(2), HTR1E(1), HTR2A(1), HTR2B(2), HTR4(1), HTR5A(1) 11095685 19 18 19 5 8 3 0 3 5 0 0.261 0.874 1.000 330 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 GRIN1(1), JAK2(1), NFKBIA(1) 5465414 3 3 3 1 0 0 0 0 3 0 0.749 0.880 1.000 331 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(2), ENPP1(1), ENPP3(2), NADSYN1(1), NNMT(1), NT5C(2), NT5E(1) 9271810 10 10 10 3 1 6 1 1 1 0 0.437 0.881 1.000 332 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 CHRM1(1), CHRNA1(2), FLT4(1), KDR(4), NOS3(3), PDE2A(1), PDE3A(1), PRKACG(1), PRKAR1A(2), PRKG2(1), RYR2(10), TNNI1(1) 17456491 28 27 28 7 8 7 1 7 5 0 0.190 0.882 1.000 333 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(3), CACNA1A(2), CACNA1B(4), GNAS(3), GRM4(3), ITPR3(4), KCNB1(3), PDE1A(1), PLCB2(3), PRKACG(1), SCNN1B(1), TAS1R2(2), TAS1R3(1), TAS2R1(2), TAS2R16(2), TAS2R4(2), TAS2R40(2), TAS2R41(1), TAS2R9(1), TRPM5(1) 24573015 42 39 42 9 17 7 1 10 7 0 0.123 0.882 1.000 334 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(4), LPL(1), NCOA1(1), NCOA2(1), PPARG(1), RXRA(1) 7953781 9 9 9 3 1 4 0 3 1 0 0.628 0.883 1.000 335 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(3), ABCB4(3), ABCC3(1) 6171322 7 7 7 3 1 1 1 2 2 0 0.825 0.885 1.000 336 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS2(1), CPO(1) 3415162 2 2 2 2 0 1 0 0 1 0 0.881 0.891 1.000 337 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), PTPRU(1), REG1A(1), TYK2(2) 5388859 6 6 6 3 1 1 0 1 3 0 0.862 0.893 1.000 338 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(1), FOS(1), THBS1(1) 3184347 3 3 3 2 0 2 0 0 1 0 0.800 0.894 1.000 339 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACPP(3), ALPP(4), ALPPL2(2), CYP1A2(2), CYP2B6(1), CYP2C19(5), CYP2C8(1), CYP3A4(2), CYP3A7(1), CYP4F8(1), PON1(2) 12603661 24 21 24 6 12 3 0 3 6 0 0.299 0.895 1.000 340 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AP2M1(1), BIN1(1), SYNJ1(1), SYNJ2(3) 9282683 6 6 6 1 2 2 0 1 1 0 0.409 0.895 1.000 341 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT2(1), ECHS1(1), HADHA(2) 3360048 4 4 4 4 0 1 0 2 1 0 0.952 0.896 1.000 342 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(6), C6(1), C7(2), C8A(2) 5386542 11 11 11 6 5 2 0 1 3 0 0.791 0.898 1.000 343 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(2), TYK2(2) 4669623 4 4 4 3 1 0 0 1 2 0 0.952 0.899 1.000 344 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 FOS(1), POLR2A(1), PRKACG(1), PRKAR1A(2) 5563314 5 5 5 2 2 1 0 1 1 0 0.781 0.900 1.000 345 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IL1R1(1), IL6(1), IRAK3(1), MAP2K3(1), MAP2K6(1), MAP3K1(2), MAPK8(1), NFKBIA(1), TNF(1), TOLLIP(1) 12794546 11 11 11 2 3 5 0 1 2 0 0.194 0.900 1.000 346 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 CHST11(1), CHST13(1), SULT2B1(2) 3959948 4 3 4 2 1 0 0 2 1 0 0.865 0.900 1.000 347 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(1), FOS(1), GNAI1(3), GNAS(3), NFATC1(1), NFATC2(2), NFATC4(1), PLCG1(4), PRKACG(1), PRKAR1A(2), PRKCA(1), RAF1(1), RPS6KA3(1) 15077643 22 22 21 5 6 5 0 5 6 0 0.320 0.902 1.000 348 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ARPC1B(1) 3494857 1 1 1 1 0 1 0 0 0 0 0.899 0.904 1.000 349 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BRAF(3), CREB3(3), MAPK1(1), MKNK1(1), RPS6KA1(1), RPS6KA3(1), SHC1(1), SOS2(1) 12728816 12 12 12 3 0 3 0 6 3 0 0.658 0.906 1.000 350 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CHIA(1), GFPT1(1), GFPT2(2), GNPDA1(1), HEXA(1), HK1(3), HK3(1), MTMR6(1), PGM3(1), RENBP(3) 12384265 15 15 15 4 2 6 0 4 3 0 0.432 0.906 1.000 351 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(1), ACAT2(1), ECHS1(1), HADHA(2) 3600996 5 5 5 3 0 2 0 2 1 0 0.833 0.907 1.000 352 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 HEXA(1), ST3GAL1(1) 4634004 2 2 2 1 0 0 1 0 1 0 0.919 0.907 1.000 353 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(1), ABP1(3), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), CNDP1(1), DPYS(2), ECHS1(1), GAD2(1), HADHA(2) 11632891 18 17 18 5 9 2 0 2 5 0 0.308 0.908 1.000 354 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 FDPS(1), IDI1(1), MVD(1), NSDHL(2) 8309818 5 5 5 1 2 1 0 1 1 0 0.555 0.908 1.000 355 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(2), CD44(2), TNF(1), TNFSF8(1) 5664869 6 6 6 3 2 3 0 0 1 0 0.711 0.909 1.000 356 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ECHS1(1), HADHA(2) 5245847 10 10 10 5 4 2 0 1 3 0 0.689 0.912 1.000 357 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 GFPT1(1), GNPDA1(1), HEXA(1), HK1(3), HK3(1), PGM3(1), RENBP(3) 7320472 11 11 11 4 1 5 0 3 2 0 0.613 0.913 1.000 358 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 PRMT5(2), PRMT8(1) 6064239 3 3 3 0 0 2 1 0 0 0 0.317 0.913 1.000 359 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 DNMT1(1), DNMT3A(4), DNMT3B(1), MARS2(1) 7506034 7 7 7 2 2 2 0 2 1 0 0.471 0.914 1.000 360 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(1), ADCY3(1), ADCY9(2), ATP6V0A2(1), ATP6V1C2(1), ATP6V1D(1), ERO1L(1), GNAS(3), PLCG1(4), PLCG2(4), PRKCA(1) 15919630 20 19 19 4 10 5 0 2 3 0 0.181 0.915 1.000 361 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(1), EXT2(1), EXTL1(2), HS3ST3A1(1), HS6ST2(2), NDST2(1), NDST3(2) 8957134 10 10 10 3 4 1 1 3 1 0 0.499 0.917 1.000 362 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 APC(1), DAG1(1), DLG4(1), GNAI1(3), ITPR1(2), ITPR2(4), ITPR3(4), MAPK1(1), PITX2(1), PTX3(1), RYR1(7) 19746251 26 24 26 5 4 8 2 8 4 0 0.138 0.920 1.000 363 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 GGT1(2), MARS2(1), PRMT5(2), PRMT8(1), SCLY(1) 10751059 7 7 7 1 1 4 2 0 0 0 0.206 0.921 1.000 364 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 MAP3K1(2), NFATC1(1), NFATC2(2), NFKBIA(1), PLCG1(4), PRKACG(1), PRKAR1A(2) 12065408 13 12 12 3 3 4 0 2 4 0 0.350 0.929 1.000 365 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(4), MAP2K3(1), MAP2K6(1), NFKBIA(1), NR3C1(1), TGFBR1(1), TGFBR2(1), TLR2(1), TNF(1) 12817917 12 12 12 3 3 4 0 2 3 0 0.386 0.930 1.000 366 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6(1), JAK2(1), JAK3(1), PIAS3(1), PTPRU(1), REG1A(1), STAT3(1) 6582758 8 8 8 3 2 1 0 3 2 0 0.671 0.931 1.000 367 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(1), FTCD(3), GART(1), MTHFR(1) 8151769 6 6 6 2 3 0 0 1 2 0 0.635 0.933 1.000 368 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(4), NCOA3(1), PRKACG(1), PRKAR1A(2), RXRA(1) 8917003 9 9 9 3 2 2 0 2 3 0 0.748 0.934 1.000 369 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSD(1), ARSE(1), GALC(1), LCT(2), NEU1(1), NEU2(2), SMPD2(1) 10453589 9 9 9 2 5 0 0 3 1 0 0.458 0.939 1.000 370 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 ETS1(1), ETV3(1), FOS(1), HDAC2(3), HDAC5(1), NCOR2(3), SIN3A(2) 11250231 12 11 12 3 2 1 1 1 7 0 0.716 0.942 1.000 371 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 BAX(1), CYCS(1) 5773392 2 2 2 0 0 0 0 1 1 0 0.589 0.942 1.000 372 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(1), DHRSX(1), ESCO2(1) 7119953 3 3 3 0 1 1 0 0 1 0 0.462 0.943 1.000 373 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 ICAM1(1), ITGAL(2), ITGB2(1), PRF1(1) 3774024 5 4 5 4 4 0 0 0 1 0 0.858 0.944 1.000 374 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDHPPT(1) 2997755 1 1 1 0 0 0 0 0 1 0 0.705 0.944 1.000 375 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKBIA(1), PLCB1(2), PRKCA(1) 3553840 4 4 4 3 1 0 0 2 1 0 0.905 0.948 1.000 376 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK2(1), JAK3(1), MAPK1(1), STAT3(1), TYK2(2) 5083239 6 6 6 3 2 1 0 1 2 0 0.817 0.950 1.000 377 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 MAF(1), MAP2K3(1), NFATC1(1), NFATC2(2), PRKACG(1), PRKAR1A(2) 5267777 8 8 8 4 3 0 0 3 2 0 0.780 0.950 1.000 378 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), HLA-DRA(1), IFNGR2(1), IL12B(1), IL12RB1(1), IL18(2), IL4R(1) 5454629 8 8 8 5 2 0 1 3 2 0 0.905 0.950 1.000 379 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), JAK2(1), PTPRU(1), REG1A(1) 4913825 4 4 4 3 1 1 0 0 2 0 0.877 0.950 1.000 380 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 ECHS1(1), HADHA(2), HSD17B4(2) 5103202 5 5 5 3 0 1 0 2 2 0 0.904 0.951 1.000 381 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 ABAT(1), ACADS(2), ACAT2(1), ACSM1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), ECHS1(1), GAD2(1), HADHA(2), HSD17B4(2), HSD3B7(1), ILVBL(1), L2HGDH(1), PDHA1(3), PDHA2(2), PDHB(1) 17482181 27 26 27 7 8 4 0 7 8 0 0.222 0.952 1.000 382 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CLOCK(1), PER1(2) 3683670 3 3 3 3 0 1 0 1 1 0 0.971 0.952 1.000 383 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(1), CDH1(1), CREBBP(4), TGFBR1(1), TGFBR2(1) 11063197 8 8 8 2 3 2 0 2 1 0 0.520 0.953 1.000 384 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), EGF(3), EGFR(21), GJA1(1), GNAI1(3), GNAS(3), GRM5(1), GUCY1A3(1), GUCY2C(2), GUCY2F(2), HTR2A(1), HTR2B(2), ITPR1(2), ITPR2(4), ITPR3(4), KRAS(1), MAP2K5(1), MAPK1(1), MAPK7(3), NRAS(1), PDGFA(1), PDGFC(1), PDGFD(1), PDGFRA(7), PLCB1(2), PLCB2(3), PLCB4(1), PRKACG(1), PRKCA(1), PRKCG(1), PRKG2(1), RAF1(1), SOS2(1), TJP1(3), TUBA3C(2), TUBA3D(1), TUBB3(1), TUBB6(1), TUBB8(1) 57044120 98 77 92 17 26 23 2 27 20 0 0.00359 0.953 1.000 385 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(2), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH3B2(1), ALDH7A1(1), FBP2(1), G6PC(3), G6PC2(1), HK1(3), HK3(1), LDHA(1), LDHAL6B(1), LDHB(1), PDHA1(3), PDHA2(2), PDHB(1), PFKL(1), PGAM2(1), PGK1(1), PGM3(1), PKLR(1) 25089207 38 36 38 9 13 10 1 9 5 0 0.0740 0.954 1.000 386 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 FBP2(1), G6PD(2), PFKL(1), PGM3(1), PRPS1(1), PRPS1L1(1), PRPS2(1), TALDO1(1), TKTL2(1) 10480608 10 10 10 3 6 2 0 2 0 0 0.372 0.958 1.000 387 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(1), ICAM1(1), ITGAL(2), ITGB2(1), PTPRC(3) 4634569 8 7 8 4 5 1 0 1 1 0 0.667 0.958 1.000 388 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(1), ICAM1(1), ITGAL(2), ITGB2(1), PTPRC(3) 4860225 8 7 8 4 5 1 0 1 1 0 0.676 0.962 1.000 389 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(1), ACACA(4), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH6A1(1), ECHS1(1), HADHA(2), LDHA(1), LDHB(1) 14264471 19 18 19 5 7 5 0 4 3 0 0.311 0.962 1.000 390 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 ANKRD6(1), APC(1), CTNNB1(1), DKK2(2), LRP1(5), NKD2(1), SENP2(1), WIF1(2) 17407482 14 14 14 2 4 2 0 5 3 0 0.224 0.963 1.000 391 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 SREBF1(3) 5204811 3 2 3 0 0 2 0 1 0 0 0.351 0.966 1.000 392 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 F13B(1), HSD17B4(2), HSD3B2(1) 3487550 4 4 4 3 1 0 0 2 1 0 0.944 0.967 1.000 393 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), IFNAR1(2), MAPK8(1) 4779366 4 4 4 3 0 2 0 1 1 0 0.898 0.969 1.000 394 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX3(1), FADS2(1), FASN(1), HADHA(2), PECR(1) 6238209 6 6 6 4 0 2 0 2 2 0 0.895 0.971 1.000 395 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 GREB1(2) 4723804 2 2 2 0 2 0 0 0 0 0 0.416 0.972 1.000 396 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(3), AMY2B(1), ENPP1(1), ENPP3(2), G6PC(3), GANAB(2), HK1(3), HK3(1), MGAM(3), PGM3(1), PYGB(1), PYGL(1), SI(4), UGT1A1(3), UGT2B4(1), UXS1(2) 24520261 32 30 32 6 10 11 0 7 4 0 0.0668 0.972 1.000 397 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 FBP2(1), G6PD(2), PGM3(1), PRPS1(1), PRPS1L1(1), PRPS2(1), TALDO1(1) 8812474 8 8 8 3 5 2 0 1 0 0 0.490 0.972 1.000 398 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ASPH(2), LDHA(1), NOS3(3) 7331427 6 5 6 2 3 1 0 2 0 0 0.599 0.972 1.000 399 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 ABAT(1), ADSL(1), AGXT2(1), ASL(1), ASNS(1), CAD(2), CRAT(1), GAD2(1), PC(1) 11236344 10 9 10 2 5 2 0 1 2 0 0.359 0.972 1.000 400 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 MAPK1(1), RAF1(1) 3552238 2 2 2 2 0 1 0 0 1 0 0.864 0.972 1.000 401 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH3B2(1), FBP2(1), G6PC(3), HK1(3), HK3(1), LDHA(1), LDHB(1), PDHA1(3), PDHA2(2), PDHB(1), PGK1(1), PGM3(1), PKLR(1) 21059834 32 31 32 8 9 11 1 6 5 0 0.108 0.973 1.000 402 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH3B2(1), FBP2(1), G6PC(3), HK1(3), HK3(1), LDHA(1), LDHB(1), PDHA1(3), PDHA2(2), PDHB(1), PGK1(1), PGM3(1), PKLR(1) 21059834 32 31 32 8 9 11 1 6 5 0 0.108 0.973 1.000 403 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(2), APOA1(1), APOA4(1), LIPC(1), LPL(1), LRP1(5), SCARB1(1), SOAT1(1) 11796740 13 13 13 4 4 3 0 5 1 0 0.545 0.973 1.000 404 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(1), B3GNT3(1), B3GNT4(1), B3GNT5(2), FUT5(1), ST3GAL6(1) 6989115 7 7 7 3 0 3 0 2 2 0 0.725 0.974 1.000 405 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(1), CREBBP(4), CSNK2A1(1), CTNNB1(1), WIF1(2) 12657940 9 9 9 2 1 3 0 2 3 0 0.479 0.975 1.000 406 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT7(1), CHST1(1), FUT8(1), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1) 5385912 6 6 6 3 3 2 1 0 0 0 0.702 0.975 1.000 407 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 ETV5(1), IL12B(1), IL12RB1(1), IL18(2), JAK2(1), MAP2K6(1), MAPK8(1), TYK2(2) 8053825 10 10 10 6 2 2 1 2 3 0 0.909 0.976 1.000 408 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACTB(1), ACTG1(1), ACTN3(1), ACTN4(1), ACVR1C(1), CDH1(1), CREBBP(4), CSNK2A1(1), CTNNA2(1), CTNNA3(1), CTNNB1(1), EGFR(21), ERBB2(1), FARP2(1), IGF1R(2), IQGAP1(2), LMO7(1), MAPK1(1), MET(4), MLLT4(1), PTPRB(2), PTPRF(2), PTPRJ(2), PTPRM(2), PVRL3(1), RAC2(1), SMAD2(1), SMAD3(1), TCF7L2(2), TGFBR1(1), TGFBR2(1), TJP1(3), VCL(1), WAS(2), WASF3(2), YES1(1) 51612038 73 60 67 10 17 22 1 19 14 0 0.000786 0.976 1.000 409 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSD(1), ARSE(1), DEGS1(1), GALC(1), LCT(2), NEU1(1), NEU2(2), SMPD2(1), SMPD3(1), SMPD4(1) 15432647 12 12 12 2 5 2 0 3 2 0 0.280 0.976 1.000 410 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 YWHAH(1) 3328052 1 1 1 0 0 0 0 0 1 0 1.000 0.976 1.000 411 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 IL12B(1), IL12RB1(1), JAK2(1), TYK2(2) 6351991 5 5 5 4 1 0 1 1 2 0 0.949 0.977 1.000 412 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 GGT1(2), LTA4H(1), PTGS1(1), PTGS2(1) 6507513 5 5 5 2 2 1 0 1 1 0 0.674 0.977 1.000 413 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), AGK(1), AGPAT2(1), AGPAT3(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), DGKA(1), DGKD(2), DGKH(1), DGKQ(1), GK(1), GK2(3), GPAM(1), LCT(2), LIPC(1), LIPG(1), LPL(1), PNLIPRP1(2) 25285723 32 26 32 6 14 8 1 5 4 0 0.0355 0.977 1.000 414 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(1), GART(1), MTHFR(1) 7692807 3 3 3 1 1 0 0 1 1 0 0.671 0.979 1.000 415 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 RPL10L(1), RPL37A(1), RPL7(1), RPS2(1), RPS24(1) 9704954 5 5 5 1 2 0 0 2 1 0 0.724 0.980 1.000 416 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C3(6), C6(1), C7(2), C8A(2), MBL2(2) 9142828 13 13 13 6 5 3 0 1 4 0 0.719 0.980 1.000 417 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C3(6), C6(1), C7(2), C8A(2) 7513172 11 11 11 6 5 2 0 1 3 0 0.793 0.980 1.000 418 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(1), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), SOAT2(1), SRD5A1(1) 10006782 15 15 15 5 6 3 0 3 3 0 0.428 0.980 1.000 419 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V1C2(1), ATP6V1D(1) 6479542 2 2 2 0 1 1 0 0 0 0 0.457 0.980 1.000 420 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V1C2(1), ATP6V1D(1) 6479542 2 2 2 0 1 1 0 0 0 0 0.457 0.980 1.000 421 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V1C2(1), ATP6V1D(1) 6479542 2 2 2 0 1 1 0 0 0 0 0.457 0.980 1.000 422 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK2(1), JAK3(1), PIAS3(1), PTPRU(1), REG1A(1), SOAT1(1) 5912503 7 7 7 5 1 1 0 3 2 0 0.942 0.980 1.000 423 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ASL(1), CPS1(2), GLUD1(2) 7581686 5 4 5 3 0 0 0 2 3 0 0.967 0.981 1.000 424 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 F13A1(2), F2(3), FGA(1), FGB(1), FGG(1) 5768302 8 8 8 4 3 2 0 2 1 0 0.730 0.982 1.000 425 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(1), CREBBP(4), CTNNB1(1), LDB1(1), PITX2(1), TRRAP(4) 14301196 12 12 12 3 5 2 0 3 2 0 0.438 0.984 1.000 426 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 AGPAT2(1), AGPAT3(1), CHAT(1), DGKA(1), DGKD(2), DGKH(1), DGKQ(1), ESCO2(1), GNPAT(1), GPAM(1), LYPLA1(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PLD1(3) 28246196 22 20 22 2 8 6 1 3 4 0 0.0289 0.985 1.000 427 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 PRF1(1), SREBF1(3) 7906605 4 3 4 1 1 2 0 1 0 0 0.603 0.985 1.000 428 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ARPC1B(1), NCK1(1), NCKAP1(2), WASF3(2) 6568726 6 5 6 3 2 2 0 1 1 0 0.722 0.985 1.000 429 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V1C2(1), ATP6V1D(1) 6897071 2 2 2 0 1 1 0 0 0 0 0.458 0.987 1.000 430 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), AGPAT2(1), AGPAT3(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), DGKA(1), DGKD(2), DGKH(1), DGKQ(1), GK(1), LCT(2), LIPC(1), LIPG(1), LPL(1), PNLIPRP1(2) 20776832 27 23 27 6 12 6 1 4 4 0 0.0907 0.988 1.000 431 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT2(1), ACOT11(1), DHRS2(1), DHRSX(1), ECHS1(1), ESCO2(1), FN3K(1), HADHA(2) 11166274 9 8 9 3 2 2 0 2 3 0 0.672 0.989 1.000 432 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 FBP2(1), PGK1(1), PKLR(1) 7793275 3 3 3 1 2 1 0 0 0 0 0.599 0.990 1.000 433 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMC3(1) 5546589 1 1 1 0 0 1 0 0 0 0 0.677 0.990 1.000 434 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(1), CYCS(1), MAP3K1(2), MAPK1(1), MAPK8(1), RAF1(1), RIPK1(1), TRADD(1) 8865443 9 9 9 4 2 3 0 1 3 0 0.683 0.990 1.000 435 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BNIP1(1), STX11(1), TSNARE1(1), USE1(1), VAMP5(2) 7208649 6 6 5 3 3 1 0 0 2 0 0.706 0.991 1.000 436 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(6), C6(1), C7(2), ICAM1(1), IL6(1), ITGA4(1), ITGAL(2), ITGB2(1), SELP(1), SELPLG(1), TNF(1) 10658859 18 18 18 8 7 5 0 2 4 0 0.522 0.991 1.000 437 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 FOS(1), MAPK1(1), NFKBIA(1), PLCB1(2), PRKCA(1), RAF1(1), TNF(1) 6692104 8 8 8 4 1 3 0 2 2 0 0.692 0.991 1.000 438 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), TGFBR1(1), TGFBR2(1) 4546608 3 3 3 2 2 1 0 0 0 0 0.809 0.992 1.000 439 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 CP(1), EPRS(1), HCCS(2), PPOX(1), UGT1A1(3), UGT2B4(1) 11797588 9 9 9 3 0 4 0 5 0 0 0.666 0.992 1.000 440 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(4), NFKBIA(1), RIPK1(1), TNF(1), TRADD(1) 9661334 8 8 8 3 2 2 0 1 3 0 0.708 0.993 1.000 441 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C3(6), C6(1), C7(2), C8A(2), C8B(1) 8931559 12 12 12 7 5 3 0 1 3 0 0.820 0.993 1.000 442 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 MAP3K1(2), NFKBIA(1), TNFAIP3(1) 7828857 4 4 4 2 2 1 0 0 1 0 0.719 0.994 1.000 443 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(1), ACAA2(1), ACADS(2), ACAT2(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH6A1(1), ALDH7A1(1), AOX1(2), DBT(1), ECHS1(1), HADHA(2), HSD17B4(2), MCCC1(1), MCCC2(2) 18519097 24 21 23 6 9 5 0 4 6 0 0.258 0.994 1.000 444 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 DAG1(1), ITPR1(2), ITPR2(4), ITPR3(4), NFAT5(2), PDE6B(3), PDE6C(3) 15443890 19 18 19 6 5 7 1 4 2 0 0.391 0.994 1.000 445 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVRL1(2), BUB1(1), CLK1(1), CLK4(1), CSNK2A1(1), DGKA(1), DGKD(2), DGKH(1), DGKQ(1), INPP4B(1), INPPL1(1), MAP3K10(1), OCRL(2), PAK4(1), PIK3C2B(1), PIK3CA(28), PIK3CG(2), PLCB1(2), PLCB2(3), PLCB4(1), PLCG1(4), PLCG2(4), PRKACG(1), PRKAR1A(2), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(1), RAF1(1), RPS6KA1(1), RPS6KA3(1), TGFBR1(1), VRK1(2) 48636298 75 63 62 14 14 28 3 16 14 0 0.0143 0.995 1.000 446 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 GLI3(1), PRKACG(1), PRKAR1A(2), SHH(1), SUFU(1) 7202261 6 6 6 4 1 2 0 1 2 0 0.919 0.995 1.000 447 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(4), MAPK1(1) 6384633 5 5 5 3 1 2 0 1 1 0 0.898 0.995 1.000 448 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 UGT1A1(3), UGT2B4(1) 7577691 4 4 4 2 0 1 0 3 0 0 0.842 0.996 1.000 449 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL22RA1(1), JAK2(1), JAK3(1), STAT3(1), STAT5B(1), TYK2(2) 7950800 7 7 7 5 2 0 0 3 2 0 0.961 0.996 1.000 450 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(1) 5504515 1 1 1 0 0 1 0 0 0 0 0.673 0.996 1.000 451 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGTR2(1), F2(3), GNAI1(3), JAK2(1), MAPK1(1), MAPK8(1), MYLK(1), PLCG1(4), PRKCA(1), PTK2B(1), RAF1(1), SHC1(1), STAT3(1) 17953288 20 19 19 5 4 8 0 3 5 0 0.241 0.996 1.000 452 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 MAP3K1(2), NFKBIA(1), RIPK1(1), TANK(2), TNFAIP3(1) 9689912 7 7 7 3 3 2 0 0 2 0 0.667 0.996 1.000 453 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 DLG4(1), GRIN1(1), GRIN2A(3), GRIN2B(3), GRIN2C(2), GRIN2D(2), NOS1(1), PRKACG(1), PRKAR1A(2), PRKCA(1) 11039485 17 16 17 9 5 2 0 6 4 0 0.902 0.996 1.000 454 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(1), ABP1(3), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), CNDP1(1), DPYS(2), ECHS1(1), GAD2(1), HADHA(2) 12519589 18 17 18 7 8 3 0 2 5 0 0.546 0.996 1.000 455 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(2), HDAC2(3), NFATC1(1), NFATC2(2), PRKCA(1) 10507499 9 9 9 7 2 1 1 1 4 0 0.985 0.996 1.000 456 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(1), ALDH4A1(1), CAD(2), CPS1(2), EPRS(1), GAD2(1), GFPT1(1), GLUD1(2), GSS(1), NADSYN1(1) 14288654 13 13 13 4 3 4 0 3 3 0 0.621 0.996 1.000 457 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 BRAF(3), CACNA1A(2), GNAI1(3), GNAO1(3), GNAS(3), GRIA1(5), GRIA3(4), GRID2(1), GRM5(1), GUCY1A3(1), GUCY2C(2), GUCY2F(2), IGF1R(2), ITPR1(2), ITPR2(4), ITPR3(4), KRAS(1), MAPK1(1), NOS1(1), NOS3(3), NRAS(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PLCB1(2), PLCB2(3), PLCB4(1), PPP2R2C(1), PRKCA(1), PRKCG(1), PRKG2(1), RAF1(1), RYR1(7) 47597813 74 61 74 14 18 22 3 18 13 0 0.0113 0.996 1.000 458 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(1), FUCA1(1), FUCA2(2), HEXA(1), LCT(2), MAN2B1(1), MAN2B2(1), MAN2C1(1), NEU1(1), NEU2(2) 8803573 13 13 13 6 4 2 1 3 3 0 0.787 0.997 1.000 459 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 IL4R(1), IRS1(2), JAK3(1), SHC1(1), STAT6(2) 6395596 7 7 7 4 2 1 0 3 1 0 0.830 0.997 1.000 460 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR7(1), CD28(1), CXCR4(1), IFNGR2(1), IL12B(1), IL12RB1(1), IL4R(1) 8618564 7 7 7 7 1 1 2 1 2 0 0.980 0.997 1.000 461 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 BMPR1B(1), CDKN1B(1), DMC1(1), ESR2(2), FSHR(1), MLH1(2), MSH5(1), NCOR1(3), ZP2(1) 15109417 13 13 13 4 2 4 0 3 4 0 0.692 0.997 1.000 462 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(1) 5765659 1 1 1 0 0 1 0 0 0 0 0.673 0.997 1.000 463 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMC3(1) 6887116 1 1 1 1 0 1 0 0 0 0 0.947 0.997 1.000 464 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(1), ACADS(2), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH6A1(1), AOX1(2), ECHS1(1), HADHA(2), MCCC1(1), MCCC2(2) 15504048 20 19 19 7 7 6 0 3 4 0 0.423 0.997 1.000 465 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(3), ADC(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), ASL(1), ASS1(1), CPS1(2) 12722162 15 15 15 9 8 1 0 1 5 0 0.916 0.998 1.000 466 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN3(1), CTNNA2(1), CTNNB1(1), VCL(1) 8298512 4 4 4 2 1 0 0 2 1 0 0.884 0.998 1.000 467 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 GTF2E1(1), NCOA1(1), NCOA2(1), NCOA3(1), NCOR2(3), POLR2A(1), RXRA(1) 10772473 9 9 9 6 3 3 0 0 3 0 0.919 0.998 1.000 468 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG5(1), FUT8(1), MGAT2(1), MGAT3(2), MGAT5(1) 8605344 6 6 6 3 2 2 0 1 1 0 0.786 0.998 1.000 469 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(1), COL4A4(1), COL4A5(3), COL4A6(3), SLC23A1(1), SLC23A2(1), SLC2A3(1) 10797020 11 11 11 5 5 4 1 1 0 0 0.512 0.998 1.000 470 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 IL12B(1), ITGAX(1), TLR2(1), TLR7(2), TLR9(2) 8005526 7 6 7 4 2 0 1 3 1 0 0.916 0.998 1.000 471 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 PLCB1(2), PRKACG(1), PRKAR1A(2) 6918479 5 5 5 3 1 0 0 3 1 0 0.962 0.998 1.000 472 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(3), ALDH1A3(1), ALDH3A1(3), ALDH3B2(1), DDC(1), LPO(3), MPO(2), TAT(1), TPO(3) 9486911 18 17 18 7 10 3 2 1 2 0 0.486 0.998 1.000 473 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CFL1(1), GNAS(3), LIMK1(3), MAPK1(1), PLCB1(2), PRKCA(1), RAF1(1), ROCK2(1) 10807756 13 13 13 5 2 3 0 5 3 0 0.740 0.998 1.000 474 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(3), GNAI1(3), MAPK1(1), PLA2G4A(4), PLCB1(2), PRKCA(1), PTGS1(1), RAF1(1) 10509208 16 16 16 6 1 5 0 7 3 0 0.660 0.999 1.000 475 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 FBP2(1), PGK1(1), PKLR(1), TKTL2(1) 8709804 4 4 4 2 2 1 0 1 0 0 0.736 0.999 1.000 476 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F13B(1), F2(3), F5(4), F7(1), F8(3), FGA(1), FGB(1), FGG(1), LPA(1), VWF(3) 15204486 19 17 19 7 6 5 1 3 4 0 0.458 0.999 1.000 477 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(1), ACAD8(1), ACAD9(1), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), HSD3B7(1), SOAT1(1), SOAT2(1), SRD5A1(1) 13626237 19 18 19 7 7 2 0 7 3 0 0.593 0.999 1.000 478 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 ABP1(3), ESCO2(1) 10903635 4 4 4 2 2 1 0 0 1 0 0.809 0.999 1.000 479 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CLOCK(1), PER1(2), PER2(1) 7356377 4 4 4 3 0 2 0 1 1 0 0.929 0.999 1.000 480 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 FPR1(1), MAP2K3(1), MAP2K6(1), MAP3K1(2), MAPK1(1), NCF2(1), NFATC1(1), NFATC2(2), NFATC4(1), NFKBIA(1), PAK1(1), PLCB1(2), RAF1(1) 16501654 16 15 16 5 5 2 0 3 6 0 0.427 0.999 1.000 481 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 FOS(1), MAP3K1(2), MAPK8(1), NFATC1(1), NFATC2(2), NFATC4(1), PLCG1(4), PRKCA(1), RAF1(1), SHC1(1), VAV1(3) 16478915 18 17 17 6 6 6 0 3 3 0 0.436 0.999 1.000 482 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 CYCS(1), GAS2(1), LMNA(1), NFKBIA(1), RIPK1(1), SPTAN1(2), TRADD(1) 14415675 8 6 8 2 3 1 0 1 3 0 0.467 0.999 1.000 483 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 HDAC5(1), YWHAH(1) 8738915 2 2 2 1 1 0 0 0 1 0 0.888 0.999 1.000 484 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(1), ADRBK2(1), ARRB2(1), CALML3(1), CLCA1(1), CLCA2(1), CNGA3(1), CNGB1(1), GUCA1A(1), PDE1C(1), PRKACG(1), PRKG2(1) 13145628 12 11 12 7 4 1 0 3 4 0 0.867 0.999 1.000 485 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 DNMT1(1), DNMT3A(4), DNMT3B(1), MARS2(1), TAT(1) 8945719 8 8 8 4 2 2 1 2 1 0 0.721 0.999 1.000 486 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 ARHGDIB(1), CASP1(1), CYCS(1), LMNA(1), LMNB2(1), PRF1(1) 8320667 6 5 6 3 2 2 0 2 0 0 0.815 0.999 1.000 487 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(1), AGTR2(1), CMA1(1), COL4A1(1), COL4A4(1), COL4A5(3), COL4A6(3), REN(1) 10866940 12 12 12 6 6 4 0 1 1 0 0.658 0.999 1.000 488 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 CES2(1), CYP3A4(2), UGT1A1(3) 9830157 6 6 6 3 1 1 0 3 1 0 0.856 1.000 1.000 489 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 IL1R1(1), MAP3K1(2), NFKBIA(1), RIPK1(1), TNF(1), TNFAIP3(1), TRADD(1) 10528674 8 8 8 5 3 3 0 0 2 0 0.863 1.000 1.000 490 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 150 CBLB(1), CBLC(1), CISH(1), CNTFR(1), CREBBP(4), CRLF2(2), CSF2RA(3), CSF2RB(1), GH1(1), GHR(1), IFNA21(1), IFNA5(1), IFNAR1(2), IFNGR2(1), IL12B(1), IL12RB1(1), IL13RA1(1), IL15(1), IL19(1), IL20RA(1), IL22RA1(1), IL23R(1), IL2RB(2), IL4R(1), IL6(1), IL6ST(2), IL7R(1), IL9R(2), JAK2(1), JAK3(1), LIFR(1), OSMR(1), PIAS3(1), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PIM1(1), PTPN11(5), SOCS5(1), SOS2(1), SPRED2(1), SPRY2(1), SPRY4(1), STAT3(1), STAT5B(1), STAT6(2), TPO(3), TYK2(2) 62568826 108 88 93 26 13 33 5 30 27 0 0.0908 1.000 1.000 491 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 FBP2(1), GMDS(1), HK1(3), HK3(1) 10334603 6 6 6 3 2 3 0 0 1 0 0.675 1.000 1.000 492 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(1), ATF2(1), BMP4(2), CTNNB1(1), GATA4(1), RFC1(1), TGFBR1(1), TGFBR2(1) 15690578 9 9 9 3 3 2 0 1 3 0 0.720 1.000 1.000 493 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(1), FUCA1(1), FUCA2(2), HEXA(1), HYAL1(1), IDS(1), LCT(2), MAN2B1(1), MAN2B2(1), MAN2C1(1), NAGLU(2), NEU1(1), NEU2(2), SPAM1(1) 14915874 18 18 18 6 5 4 1 4 4 0 0.541 1.000 1.000 494 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(3), ALDH1A3(1), ALDH3A1(3), ALDH3B2(1), DDC(1), ESCO2(1), LPO(3), MPO(2), TAT(1), TPO(3) 14741023 19 18 19 7 10 3 2 1 3 0 0.499 1.000 1.000 495 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ACTB(1), ACTG1(1), ARHGEF2(2), CDH1(1), CTNNB1(1), CTTN(1), HCLS1(1), NCK1(1), NCL(1), PRKCA(1), ROCK2(1), TLR5(1), TUBA3C(2), TUBA3D(1), TUBB3(1), TUBB6(1), TUBB8(1), WAS(2) 22595341 21 21 21 6 8 2 3 3 5 0 0.413 1.000 1.000 496 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ACTB(1), ACTG1(1), ARHGEF2(2), CDH1(1), CTNNB1(1), CTTN(1), HCLS1(1), NCK1(1), NCL(1), PRKCA(1), ROCK2(1), TLR5(1), TUBA3C(2), TUBA3D(1), TUBB3(1), TUBB6(1), TUBB8(1), WAS(2) 22595341 21 21 21 6 8 2 3 3 5 0 0.413 1.000 1.000 497 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ALG6(1), CELSR1(5), CELSR2(1), CELSR3(5), CHRM3(3), EMR2(1), EMR3(1), FSHR(1), GNRHR(1), GPR116(4), GPR132(1), GPR133(1), GPR17(1), GRPR(3), HRH4(1), LPHN2(2), LPHN3(3), OR8G2(2), SSTR2(1), TAAR5(1), TSHR(2) 28768948 41 40 41 11 12 14 2 9 4 0 0.111 1.000 1.000 498 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 ABAT(1), ADSL(1), ADSSL1(1), AGXT2(1), ASL(1), ASNS(1), ASS1(1), CAD(2), CRAT(1), DARS2(1), GAD2(1), PC(1), PDHA1(3), PDHA2(2), PDHB(1) 16316557 19 17 19 5 7 6 0 3 3 0 0.329 1.000 1.000 499 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 UGT1A1(3), UGT2A3(1), UGT2B10(4), UGT2B11(3), UGT2B28(2), UGT2B4(1), UGT2B7(1) 11758667 15 14 15 6 2 3 0 10 0 0 0.762 1.000 1.000 500 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN3(1), ACTN4(1), CDH5(1), CLDN11(1), CLDN14(1), CLDN16(1), CLDN19(1), CTNNA2(1), CTNNA3(1), CTNNB1(1), CXCR4(1), CYBB(1), ESAM(1), GNAI1(3), ICAM1(1), ITGA4(1), ITGAL(2), ITGB2(1), JAM2(1), MAPK12(1), MLLT4(1), MMP9(1), NCF2(1), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PLCG1(4), PLCG2(4), PRKCA(1), PRKCG(1), PTK2B(1), PTPN11(5), RAC2(1), RHOH(1), ROCK2(1), SIPA1(1), VAV1(3), VAV3(8), VCL(1) 53623857 103 80 80 24 22 28 4 19 30 0 0.0722 1.000 1.000 501 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(1), POLR2A(1), POLR2B(1), POLR2G(1), POLR3A(3), POLR3B(1), POLR3GL(1), POLR3K(1) 10106462 10 10 10 6 2 4 1 2 1 0 0.875 1.000 1.000 502 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(2), POLD1(1), POLE(1), POLQ(2), PRIM1(1), PRIM2(2), REV1(3), REV3L(1) 17383018 13 11 13 7 5 2 0 2 4 0 0.958 1.000 1.000 503 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), NFKBIA(1), RIPK1(1), TNF(1), TNFAIP3(1), TRADD(1) 11749550 6 6 6 5 2 1 0 1 2 0 0.960 1.000 1.000 504 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 EPRS(1), FARS2(2), GARS(1), HARS(1), LARS(1), MARS2(1), RARS(1), WARS2(1) 13780686 9 9 9 4 1 6 0 2 0 0 0.707 1.000 1.000 505 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 G6PC(3), G6PC2(1), GANC(1), HK1(3), HK3(1), HSD3B7(1), LCT(2), MGAM(3), PFKL(1), PGM3(1) 16696536 17 16 17 6 8 5 0 3 1 0 0.388 1.000 1.000 506 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(2), CALCR(1), CD97(1), ELTD1(1), EMR1(1), EMR2(1), GIPR(1), GLP2R(1), GPR64(2), LPHN2(2), LPHN3(3), SCTR(1) 11524661 17 15 17 8 3 6 1 6 1 0 0.796 1.000 1.000 507 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(1), FOS(1), IL2RB(2), JAK3(1), MAPK8(1), RAF1(1), SHC1(1), STAT5B(1) 10086593 9 9 9 5 0 4 0 4 1 0 0.817 1.000 1.000 508 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 PIGB(1), PIGS(1), PIGW(1), PIGZ(1) 10254746 4 4 4 3 1 0 0 2 1 0 0.943 1.000 1.000 509 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(3), CASP1(1), MAGI2(2), RERE(4) 10330481 10 10 10 5 3 2 0 4 1 0 0.880 1.000 1.000 510 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(1), ADC(1), ALDH4A1(1), CAD(2), CPS1(2), EPRS(1), GAD2(1), GFPT1(1), GFPT2(2), GLUD1(2), GLUD2(1), GSS(1), NADSYN1(1) 17016905 17 16 17 6 3 5 0 5 4 0 0.722 1.000 1.000 511 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(1), ARHGDIB(1), BAG4(1), CRADD(1), CYCS(1), LMNA(1), LMNB2(1), MAP3K1(2), MAP3K5(2), MAPK8(1), MDM2(2), NFKBIA(1), NUMA1(3), PRKDC(3), RASA1(2), RB1(3), RIPK1(1), SPTAN1(2), TNF(1), TRADD(1) 29726062 31 27 31 7 7 9 1 7 7 0 0.197 1.000 1.000 512 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AP2M1(1), EEA1(1), PFKL(1), PLCG1(4) 10751892 7 7 6 4 2 3 0 1 1 0 0.852 1.000 1.000 513 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 CREBBP(4), GTF2E1(1), HDAC2(3), HDAC4(2), HDAC5(1), HDAC6(2), NCOR2(3), POLR2A(1) 19982093 17 17 17 8 7 2 0 2 6 0 0.902 1.000 1.000 514 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG13(1), ALG14(1), ALG5(1), ALG6(1), DAD1(1), DHDDS(1), FUT8(1), GANAB(2), MAN2A1(1), MGAT2(1), MGAT3(2), MGAT5(1), MGAT5B(1), STT3B(2) 18273572 17 16 17 5 3 4 1 5 4 0 0.602 1.000 1.000 515 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 CLOCK(1), ETV6(2), HSPA8(2), IDI1(1), NCKAP1(2), NCOA4(2), PER1(2), PER2(1), SF3A3(1), TUBB3(1) 15750114 15 15 15 6 3 4 0 5 3 0 0.764 1.000 1.000 516 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 FBP2(1), G6PC(3), GANAB(2), HK1(3), HK3(1), LCT(2), MGAM(3), PGM3(1) 14071914 16 15 16 6 8 4 0 3 1 0 0.462 1.000 1.000 517 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 CTCFL(1), DOT1L(1), EHMT1(1), EHMT2(1), EZH1(1), FBXO11(1), HCFC1(2), JMJD6(1), KDM6A(1), MEN1(1), MLL(4), MLL2(9), MLL3(5), MLL5(2), OGT(5), PPP1CB(1), PRDM2(2), PRDM9(4), PRMT5(2), PRMT8(1), SATB1(1), SETD2(4), SETD8(1), SETMAR(2), STK38(1), SUV39H1(1), SUV420H1(1), SUZ12(1) 51182218 58 51 58 11 10 14 2 16 16 0 0.0753 1.000 1.000 518 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(1), ANGPTL2(1), CFL1(1), FLNA(3), FLNC(4), FSCN3(2), GDI1(2), LIMK1(3), MYH2(9), MYLK(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), ROCK2(1), RPS4X(1) 20660650 33 28 33 10 13 9 1 8 2 0 0.230 1.000 1.000 519 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTN3(1), SPTAN1(2), TLN1(3) 12318025 6 6 6 4 2 0 0 3 1 0 0.922 1.000 1.000 520 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(2), ATP4A(3), ATP6V0A2(1), ATP6V1C2(1), ATP6V1D(1), COX7B(1), NDUFA3(1), NDUFS1(1), NDUFS3(1), NDUFV2(1), SDHA(3), SDHC(1), TCIRG1(1), UQCRC1(1), UQCRH(1) 24042366 20 17 19 6 7 5 0 3 5 0 0.573 1.000 1.000 521 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(3), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A3(1), ALDH3A1(3), ALDH3B2(1), AOX1(2), DBH(1), DDC(1), HGD(2), TAT(1), TH(1), TPO(3), TYR(2) 13673039 26 25 26 10 9 5 2 6 4 0 0.503 1.000 1.000 522 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDHPPT(1), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), DOT1L(1), ECHS1(1), EHMT1(1), EHMT2(1), HADHA(2), PLOD1(1) 15982905 16 14 16 8 5 3 0 3 5 0 0.706 1.000 1.000 523 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(1), ACADS(2), ACADVL(1), ACAT2(1), ACOX3(1), ACSL1(3), ACSL4(1), ACSL6(1), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), CYP4A11(1), CYP4A22(1), ECHS1(1), HADHA(2), HSD17B4(2) 21087760 30 28 30 10 8 5 0 7 10 0 0.492 1.000 1.000 524 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 BAX(1), CASP1(1), CRADD(1), CYCS(1), FASLG(1), IKBKE(2), NFKBIA(1), NR3C1(1), RIPK1(1), TNF(1), TRADD(1) 18716575 12 12 12 8 4 2 0 3 3 0 0.941 1.000 1.000 525 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDT1(1), DIAPH2(1), MCM10(1), MCM6(1), MCM7(1), POLD1(1), POLE(1), PRIM1(1), RFC1(1), RPA1(1), UBC(2) 21782990 12 9 12 7 3 2 0 2 5 0 0.947 1.000 1.000 526 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(2), CANT1(3), CTPS2(1), DCTD(1), DHODH(1), DPYS(2), NT5C(2), NT5E(1), POLD1(1), POLE(1), POLQ(2), POLR2A(1), POLR2B(1), POLR2G(1), RRM1(1), TK2(1), UCK1(1), UMPS(1) 24720875 24 23 24 9 7 7 2 2 6 0 0.662 1.000 1.000 527 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 GTF2E1(1), GTF2H4(1), POLR1A(1), POLR2A(1), POLR2B(1), POLR2G(1), POLR3B(1), POLR3D(1), POLR3K(1), TAF6(1) 15095612 10 10 10 9 3 4 1 1 1 0 0.974 1.000 1.000 528 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR2(1), ATP8A1(1), AVPR1A(2), BRS3(1), CCR10(1), CCR7(1), CXCR4(1), FPR1(1), FSHR(1), GALR1(1), GNRHR(1), GRPR(3), MC3R(1), MC4R(1), MC5R(1), NMBR(2), NPY1R(1), NPY2R(1), OPRD1(1), PPYR1(1), SSTR2(1), SSTR3(2), SSTR4(5), TACR2(2), TACR3(1), TSHR(2) 22591653 37 33 37 13 14 11 1 9 2 0 0.287 1.000 1.000 529 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 82 CD1B(2), CD1E(2), CD22(2), CD36(1), CD44(2), CR1(3), CR2(2), CSF2RA(3), DNTT(1), FCGR1A(1), HLA-DRA(1), HLA-DRB5(2), IL1R1(1), IL1R2(1), IL4R(1), IL6(1), IL7R(1), IL9R(2), ITGA2(1), ITGA2B(1), ITGA4(1), ITGA5(1), KIT(2), MS4A1(1), TFRC(2), TNF(1), TPO(3) 35076777 42 37 42 12 11 15 1 11 4 0 0.147 1.000 1.000 530 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(2), C3(6), C4BPA(1), C4BPB(1), C6(1), C7(2), C8A(2), C8B(1), CD46(1), CFH(4), CR1(3), CR2(2), F13A1(2), F13B(1), F2(3), F5(4), F7(1), F8(3), FGA(1), FGB(1), FGG(1), KLKB1(3), MBL2(2), PROS1(1), SERPING1(2), VWF(3) 38953548 54 48 54 15 19 15 1 8 11 0 0.127 1.000 1.000 531 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), AKR1C3(2), ALDH1A3(1), ALDH3A1(3), ALDH3B2(1), CYP1A2(2), CYP2B6(1), CYP2C19(5), CYP2C8(1), CYP2S1(1), CYP3A4(2), CYP3A7(1), EPHX1(1), UGT1A1(3), UGT2A3(1), UGT2B10(4), UGT2B11(3), UGT2B28(2), UGT2B4(1), UGT2B7(1) 24695216 41 34 41 13 15 5 1 14 6 0 0.419 1.000 1.000 532 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(1), CAD(2), CANT1(3), CTPS2(1), DCTD(1), DHODH(1), DPYS(2), ENTPD5(1), ENTPD6(1), NT5C(2), NT5E(1), POLA1(2), POLD1(1), POLE(1), POLR1A(1), POLR2A(1), POLR2B(1), POLR2G(1), POLR3A(3), POLR3B(1), POLR3GL(1), POLR3K(1), PRIM1(1), PRIM2(2), RRM1(1), TK2(1), TXNRD2(1), UCK1(1), UMPS(1), UPRT(1) 34838967 39 38 39 10 6 11 4 7 11 0 0.308 1.000 1.000 533 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 ABO(1), B3GNT3(1), B3GNT4(1), B3GNT5(2), B4GALNT1(1), FUT5(1), PIGB(1), PIGS(1), PIGZ(1), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1), ST3GAL6(1), ST6GALNAC3(1), ST8SIA5(1) 20939560 16 16 16 7 4 3 1 5 3 0 0.775 1.000 1.000 534 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(1), BRAF(3), FOS(1), MAP2K3(1), MAP2K5(1), MAP2K6(1), MAP3K1(2), MAP3K10(1), MAP3K12(2), MAP3K13(1), MAP3K4(2), MAP3K5(2), MAP4K4(1), MAPK1(1), MAPK12(1), MAPK4(1), MAPK7(3), MAPK8(1), MAPK9(1), MAPKAPK5(2), MAX(3), MKNK1(1), NFKBIA(1), PAK1(1), RAF1(1), RIPK1(1), RPS6KA1(1), RPS6KA3(1), SHC1(1), TGFBR1(1), TRADD(1) 41061360 42 38 41 10 7 14 0 10 11 0 0.208 1.000 1.000 535 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(4), ACACB(5), BRAF(3), CALML3(1), CBLB(1), CBLC(1), FASN(1), FBP2(1), FLOT1(1), FLOT2(2), G6PC(3), G6PC2(1), IRS1(2), IRS4(2), KRAS(1), LIPE(1), MAPK1(1), MAPK8(1), MAPK9(1), MKNK1(1), NRAS(1), PCK1(1), PDE3A(1), PFKL(1), PHKA2(2), PHKB(1), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PKLR(1), PPARGC1A(1), PPP1CB(1), PPP1R3A(1), PRKAA1(1), PRKACG(1), PRKAR1A(2), PTPRF(2), PYGB(1), PYGL(1), RAF1(1), RAPGEF1(2), SHC1(1), SOS2(1), SREBF1(3), TSC1(1), TSC2(2) 69320633 109 88 95 25 24 38 3 23 21 0 0.0232 1.000 1.000 536 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP6(1), ARPC1B(1), CFL1(1), DIAPH1(2), LIMK1(3), MYLK(1), OPHN1(2), TLN1(3), VCL(1) 19549533 15 15 15 6 4 3 0 6 2 0 0.709 1.000 1.000 537 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(3), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A3(1), ALDH3A1(3), ALDH3B2(1), AOX1(2), DBH(1), DDC(1), ESCO2(1), HGD(2), PRMT5(2), PRMT8(1), TAT(1), TH(1), TPO(3), TYR(2), TYRP1(2) 25611800 32 29 32 10 9 8 3 6 6 0 0.345 1.000 1.000 538 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 FBP2(1), GMDS(1), HK1(3), HK3(1), HSD3B7(1), MTMR6(1), PFKL(1), TSTA3(1) 16074771 10 10 10 5 3 5 0 1 1 0 0.675 1.000 1.000 539 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 AR(1), ESR2(2), NR1H3(1), NR3C1(1), NR4A1(1), NR5A2(1), PPARG(1), RXRA(1), RXRG(3), THRA(1) 18191302 13 11 13 8 4 3 1 3 2 0 0.948 1.000 1.000 540 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 DLG4(1), LPA(1), MAP3K1(2), MAP3K5(2), MAPK8(1), NFKBIA(1), PDK1(2), PHKA2(2), PI3(1), PLD1(3), RDX(1), ROCK2(1), SRF(1) 21109372 19 19 19 7 3 4 2 8 2 0 0.749 1.000 1.000 541 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(1), CTNNB1(1), DVL2(1), FZD10(1), FZD5(1), FZD6(1), FZD7(1), FZD9(1), MAPK9(1), PAFAH1B1(2), PPP2R5E(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(1), WNT11(2), WNT16(1), WNT2(1), WNT7A(1) 25956401 21 20 21 8 10 2 0 4 5 0 0.617 1.000 1.000 542 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(1), BRAF(3), CALML3(1), CREBBP(4), GRIA1(5), GRIN1(1), GRIN2A(3), GRIN2B(3), GRIN2C(2), GRIN2D(2), GRM5(1), ITPR1(2), ITPR2(4), ITPR3(4), KRAS(1), MAPK1(1), NRAS(1), PLCB1(2), PLCB2(3), PLCB4(1), PPP1CB(1), PPP3R2(1), PRKACG(1), PRKCA(1), PRKCG(1), RAF1(1), RPS6KA1(1), RPS6KA3(1), RPS6KA6(1) 42943445 54 52 54 16 14 12 3 18 7 0 0.329 1.000 1.000 543 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASDHPPT(1), ACAT2(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), DOT1L(1), ECHS1(1), EHMT1(1), EHMT2(1), HADHA(2), HSD17B4(2), HSD3B7(1), OGDHL(1), PLOD1(1), SUV39H1(1) 25064303 21 19 21 8 7 2 0 6 6 0 0.612 1.000 1.000 544 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(1), ACTG1(1), ACTN3(1), ACTN4(1), AMOTL1(3), CASK(1), CLDN11(1), CLDN14(1), CLDN16(1), CLDN19(1), CSNK2A1(1), CTNNA2(1), CTNNA3(1), CTNNB1(1), CTTN(1), EPB41L1(1), EPB41L2(2), EPB41L3(2), EXOC4(2), GNAI1(3), HCLS1(1), INADL(1), JAM2(1), KRAS(1), LLGL2(1), MAGI2(2), MAGI3(1), MLLT4(1), MPDZ(3), MYH1(2), MYH10(2), MYH11(4), MYH13(5), MYH14(2), MYH15(5), MYH2(9), MYH3(3), MYH4(8), MYH6(2), MYH7(1), MYH7B(3), MYH8(6), NRAS(1), PPM1J(1), PPP2R2C(1), PPP2R3A(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(1), PTEN(13), RAB3B(1), RRAS(1), SPTAN1(2), TJP1(3), YES1(1) 83540076 120 93 120 26 42 25 2 28 23 0 0.0135 1.000 1.000 545 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), CALML3(1), CREB3(3), CREBBP(4), CTNNB1(1), DVL2(1), FZD10(1), FZD5(1), FZD6(1), FZD7(1), FZD9(1), GNAI1(3), GNAO1(3), GNAS(3), KIT(2), KRAS(1), MAPK1(1), NRAS(1), PLCB1(2), PLCB2(3), PLCB4(1), PRKACG(1), PRKCA(1), PRKCG(1), RAF1(1), TCF7L2(2), TYR(2), TYRP1(2), WNT11(2), WNT16(1), WNT2(1), WNT7A(1), WNT8A(1), WNT9B(1) 47099701 62 54 62 16 24 7 0 15 16 0 0.220 1.000 1.000 546 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(1), IL6ST(2), RPL23(1), RPL7(1), RPL7A(1), RPS2(1), RPS24(1), RPS4X(1), RPS6KA1(1), RPS6KA3(1), RPS6KA6(1), SLC36A2(1), UBC(2) 22538352 15 15 15 6 0 4 1 8 2 0 0.832 1.000 1.000 547 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 ABP1(3), ACAT2(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), AOX1(2), CYP1A2(2), DDC(1), ECHS1(1), HADHA(2), HSD17B4(2), LNX1(1), NFX1(1), OGDHL(1), PRMT5(2), PRMT8(1), TDO2(1), WARS2(1) 26107442 29 28 29 10 11 9 1 4 4 0 0.380 1.000 1.000 548 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN3(1), BCR(1), MAPK1(1), MAPK8(1), RAF1(1), SHC1(1), TLN1(3), VCL(1) 20351425 10 10 10 6 1 3 0 5 1 0 0.914 1.000 1.000 549 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 ALG13(1), ALG14(1), ALG6(1), B3GNT7(1), C1GALT1(1), CHPF(1), CHST1(1), CHST11(1), CHST13(1), CHSY1(1), DAD1(1), EXT1(1), EXT2(1), EXTL1(2), FUT8(1), GALNT1(1), GALNT14(1), GALNT4(1), GALNT5(1), GALNT6(1), GALNTL1(1), GALNTL4(1), GALNTL5(1), GANAB(2), HS3ST3A1(1), HS6ST2(2), MAN2A1(1), MGAT2(1), MGAT3(2), MGAT5(1), MGAT5B(1), NDST2(1), NDST3(2), OGT(5), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1), ST6GALNAC1(1), STT3B(2), WBSCR17(4), XYLT1(2) 47592682 55 48 55 14 17 12 3 14 9 0 0.205 1.000 1.000 550 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 DARS2(1), EPRS(1), FARS2(2), GARS(1), HARS(1), IARS2(1), LARS(1), MARS2(1), RARS(1), RARS2(2), WARS2(1) 23363114 13 12 13 8 1 7 0 4 1 0 0.932 1.000 1.000 551 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR1C(1), ACVR2A(2), ACVRL1(2), BMP4(2), BMPR1B(1), CREBBP(4), CUL1(1), DCN(1), GDF6(1), LEFTY2(1), LTBP1(1), MAPK1(1), PITX2(1), PPP2R2C(1), ROCK2(1), SMAD1(1), SMAD2(1), SMAD3(1), SMAD5(1), SMAD6(1), SMAD9(1), SMURF2(1), TGFBR1(1), TGFBR2(1), THBS1(1), THBS2(1), THBS4(1), TNF(1) 42787774 34 31 34 10 11 10 2 6 5 0 0.253 1.000 1.000 552 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), ADRA1B(1), ADRB2(1), ANXA6(1), ARRB2(1), ATP2B2(1), ATP2B3(3), CACNA1A(2), CACNA1B(4), CACNA1D(1), CACNA1E(6), CACNA1S(5), CACNB3(1), CALR(1), CASQ2(1), CHRM1(1), CHRM3(3), CHRM5(1), GJA1(1), GJB2(1), GJB6(1), GNAO1(3), GNB2(1), GNG12(1), GRK4(1), ITPR1(2), ITPR2(4), ITPR3(4), KCNB1(3), MYCBP(1), PEA15(1), PRKAR1A(2), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(1), RGS19(1), RGS3(4), RGS6(1), RGS9(1), RYR1(7), RYR2(10), RYR3(3), SLC8A3(2), YWHAH(1) 80909542 104 75 103 28 34 23 4 24 19 0 0.106 1.000 1.000 553 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(3), AMY2B(1), DDX4(2), DDX51(2), DDX52(1), DDX55(1), DDX56(1), ENPP1(1), ENPP3(2), G6PC(3), G6PC2(1), GANC(1), HK1(3), HK3(1), IFIH1(2), MGAM(3), MOV10L1(1), PGM3(1), PYGB(1), PYGL(1), RAD54L(1), RUVBL2(1), SETX(3), SI(4), SKIV2L2(1), UGT1A1(3), UGT2A3(1), UGT2B10(4), UGT2B11(3), UGT2B28(2), UGT2B4(1), UGT2B7(1), UXS1(2) 53282909 59 52 59 17 17 18 0 17 7 0 0.231 1.000 1.000 554 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(1), ACTG1(1), ACTN3(1), ACTN4(1), BRAF(3), COL11A1(1), COL1A2(5), COL2A1(1), COL3A1(3), COL4A1(1), COL4A4(1), COL4A6(3), COL5A1(1), COL5A2(1), COL6A3(6), COL6A6(1), CTNNB1(1), DIAPH1(2), DOCK1(1), EGF(3), EGFR(21), ERBB2(1), FARP2(1), FLNA(3), FLNB(4), FLNC(4), HGF(2), IBSP(1), IGF1R(2), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(1), ITGA4(1), ITGA5(1), ITGA8(1), ITGB6(1), ITGB7(1), ITGB8(1), KDR(4), LAMA1(3), LAMA2(3), LAMA3(8), LAMA4(1), LAMA5(5), LAMB1(1), LAMB4(3), LAMC1(1), LAMC2(1), LAMC3(2), MAPK1(1), MAPK8(1), MAPK9(1), MET(4), MYLK(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PARVB(1), PDGFA(1), PDGFC(1), PDGFD(1), PDGFRA(7), PGF(1), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PPP1CB(1), PRKCA(1), PRKCG(1), PTEN(13), RAC2(1), RAF1(1), RAPGEF1(2), RELN(4), ROCK2(1), SHC1(1), SOS2(1), SPP1(1), THBS1(1), THBS2(1), THBS4(1), TLN1(3), TLN2(1), TNC(2), TNN(2), TNR(1), TNXB(4), VAV1(3), VAV3(8), VCL(1), VEGFB(2), VEGFC(2), VWF(3) 160129234 252 151 224 61 58 75 7 59 53 0 0.00286 1.000 1.000 555 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ACTN3(1), ACTN4(1), APC(1), ARHGEF12(1), ARHGEF4(2), ARHGEF6(2), ARPC1B(1), BRAF(3), CFL1(1), CHRM1(1), CHRM3(3), CHRM5(1), CYFIP2(1), DIAPH1(2), DIAPH2(1), DIAPH3(1), DOCK1(1), EGF(3), EGFR(21), F2(3), FGF4(1), FGF5(2), FGF6(1), FGF7(1), FGFR2(1), FGFR4(1), GNG12(1), IQGAP1(2), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(1), ITGA4(1), ITGA5(1), ITGA8(1), ITGAD(1), ITGAE(1), ITGAL(2), ITGAX(1), ITGB2(1), ITGB6(1), ITGB7(1), ITGB8(1), KRAS(1), LIMK1(3), MAPK1(1), MYH10(2), MYH14(2), MYLK(1), NCKAP1(2), NCKAP1L(2), NRAS(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PDGFA(1), PDGFRA(7), PFN4(1), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PIP4K2B(1), PIP4K2C(2), PPP1CB(1), RAC2(1), RAF1(1), RDX(1), ROCK2(1), RRAS(1), SCIN(1), SOS2(1), SSH1(1), TIAM1(2), TIAM2(2), VAV1(3), VAV3(8), VCL(1), WAS(2) 119270812 181 132 154 45 26 52 6 49 48 0 0.0642 1.000 1.000 556 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY7(1), ADCY9(2), ADRA1B(1), ADRB2(1), ATP2B2(1), ATP2B3(3), AVPR1A(2), CACNA1A(2), CACNA1B(4), CACNA1D(1), CACNA1E(6), CACNA1F(3), CACNA1G(1), CACNA1H(2), CACNA1I(1), CACNA1S(5), CALML3(1), CHRM1(1), CHRM3(3), CHRM5(1), EGFR(21), ERBB2(1), ERBB3(1), ERBB4(1), GNAS(3), GRIN1(1), GRIN2A(3), GRIN2C(2), GRIN2D(2), GRM5(1), GRPR(3), HRH1(1), HTR2A(1), HTR2B(2), HTR4(1), HTR5A(1), ITPR1(2), ITPR2(4), ITPR3(4), MYLK(1), NOS1(1), NOS3(3), P2RX1(1), P2RX2(1), P2RX3(1), P2RX4(1), PDE1A(1), PDE1B(1), PDE1C(1), PDGFRA(7), PHKA2(2), PHKB(1), PLCB1(2), PLCB2(3), PLCB4(1), PLCD3(2), PLCE1(3), PLCG1(4), PLCG2(4), PLCZ1(1), PPP3R2(1), PRKACG(1), PRKCA(1), PRKCG(1), PTAFR(1), PTK2B(1), RYR1(7), RYR2(10), RYR3(3), SLC25A5(1), SLC8A3(2), TACR2(2), TACR3(1), VDAC3(2) 116292582 179 120 172 50 51 48 4 44 32 0 0.0633 1.000 1.000 557 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(2), ADRA1B(1), ADRB2(1), AGTR2(1), AVPR1A(2), BRS3(1), CALCR(1), CHRM1(1), CHRM3(3), CHRM5(1), CTSG(1), DRD5(3), F2(3), F2RL1(2), FPR1(1), FSHR(1), GABRA1(3), GABRA3(2), GABRA4(3), GABRA5(1), GABRA6(3), GABRB1(2), GABRB2(2), GABRB3(1), GABRE(2), GABRG2(1), GABRG3(1), GABRP(1), GALR1(1), GH1(1), GHR(1), GIPR(1), GLP2R(1), GLRA1(1), GLRB(1), GNRHR(1), GPR156(1), GPR35(1), GPR50(2), GPR83(1), GRIA1(5), GRIA3(4), GRID2(1), GRIK2(1), GRIK4(1), GRIN1(1), GRIN2A(3), GRIN2B(3), GRIN2C(2), GRIN2D(2), GRIN3A(1), GRM3(1), GRM4(3), GRM5(1), GRM6(2), GRM7(2), GRPR(3), HCRTR2(1), HRH1(1), HRH4(1), HTR1B(2), HTR1E(1), HTR2A(1), HTR2B(2), HTR4(1), HTR5A(1), MC3R(1), MC4R(1), MC5R(1), MCHR2(1), MTNR1A(1), NMBR(2), NMUR2(1), NPY1R(1), NPY2R(1), NR3C1(1), OPRD1(1), P2RX1(1), P2RX2(1), P2RX3(1), P2RX4(1), P2RY2(1), P2RY6(1), PPYR1(1), PTAFR(1), PTH2R(1), RXFP2(2), SCTR(1), SSTR2(1), SSTR3(2), SSTR4(5), TAAR5(1), TACR2(2), TACR3(1), THRA(1), TSHR(2), UTS2R(1) 95686409 147 109 147 46 56 36 2 34 19 0 0.0682 1.000 1.000 558 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(1), ACTG1(1), COL11A1(1), COL17A1(1), COL1A2(5), COL2A1(1), COL3A1(3), COL4A1(1), COL4A4(1), COL4A6(3), COL5A1(1), COL5A2(1), COL6A3(6), COL6A6(1), DSC1(1), DSC2(1), DSC3(2), DSG1(2), DSG2(3), DSG3(2), DSG4(1), GJA1(1), GJA3(1), GJA8(1), GJB2(1), GJB6(1), GJC3(1), IBSP(1), KRT15(2), KRT16(1), KRT17(1), KRT20(3), KRT27(1), KRT28(2), KRT3(3), KRT31(2), KRT33A(2), KRT33B(2), KRT34(1), KRT35(1), KRT36(1), KRT37(2), KRT39(1), KRT6B(1), KRT6C(2), KRT71(1), KRT73(2), KRT75(1), KRT76(1), KRT8(1), KRT83(2), KRT84(1), KRT86(1), KRT9(1), LAMA1(3), LAMA2(3), LAMA3(8), LAMA4(1), LAMA5(5), LAMB1(1), LAMB4(3), LAMC1(1), LAMC2(1), LAMC3(2), LMNA(1), LMNB2(1), NES(1), RELN(4), SPP1(1), THBS1(1), THBS2(1), THBS4(1), TNC(2), TNN(2), TNR(1), TNXB(4), VWF(3) 107479881 136 103 136 53 59 35 3 28 11 0 0.445 1.000 1.000 559 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR2A(2), BMPR1B(1), CCL20(1), CCR7(1), CD70(1), CNTFR(1), CRLF2(2), CSF2RA(3), CSF2RB(1), CXCL13(1), CXCL9(1), CXCR4(1), EDA(1), EDAR(3), EGF(3), EGFR(21), FASLG(1), FLT4(1), GH1(1), GHR(1), HGF(2), IFNA21(1), IFNA5(1), IFNAR1(2), IFNGR2(1), IL12B(1), IL12RB1(1), IL13RA1(1), IL15(1), IL17RA(1), IL18(2), IL19(1), IL1R1(1), IL1R2(1), IL20RA(1), IL22RA1(1), IL23R(1), IL2RB(2), IL4R(1), IL6(1), IL6ST(2), IL7R(1), IL9R(2), KDR(4), KIT(2), LIFR(1), LTBR(2), MET(4), OSMR(1), PDGFC(1), PDGFRA(7), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF10C(1), TNFRSF13B(1), TNFRSF14(1), TNFRSF6B(1), TNFRSF9(2), TNFSF14(1), TNFSF15(2), TNFSF8(1), TNFSF9(1), TPO(3), VEGFB(2), VEGFC(2), XCL1(1) 76428621 121 87 114 43 22 43 4 34 18 0 0.409 1.000 1.000 560 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 CD36(1), CD44(2), COL11A1(1), COL1A2(5), COL2A1(1), COL3A1(3), COL4A1(1), COL4A4(1), COL4A6(3), COL5A1(1), COL5A2(1), COL6A3(6), COL6A6(1), DAG1(1), FNDC1(2), FNDC3A(2), HSPG2(6), IBSP(1), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(1), ITGA4(1), ITGA5(1), ITGA8(1), ITGB6(1), ITGB7(1), ITGB8(1), LAMA1(3), LAMA2(3), LAMA3(8), LAMA4(1), LAMA5(5), LAMB1(1), LAMB4(3), LAMC1(1), LAMC2(1), LAMC3(2), RELN(4), SDC1(1), SPP1(1), THBS1(1), THBS2(1), THBS4(1), TNC(2), TNN(2), TNR(1), TNXB(4), VWF(3) 96715339 99 80 99 39 38 33 3 17 8 0 0.394 1.000 1.000 561 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABLIM1(2), ABLIM3(2), ARHGEF12(1), CFL1(1), CXCR4(1), DCC(2), EFNB3(1), EPHA3(4), EPHA4(3), EPHA5(3), EPHA6(1), EPHA7(1), EPHA8(1), EPHB6(3), GNAI1(3), KRAS(1), L1CAM(1), LIMK1(3), LRRC4C(1), MAPK1(1), MET(4), NCK1(1), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), NGEF(1), NRAS(1), NTN4(1), NTNG1(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PLXNA1(2), PLXNA2(1), PLXNA3(4), PLXNB1(1), PLXNB3(1), PPP3R2(1), RAC2(1), RASA1(2), RGS3(4), RHOD(1), ROBO1(1), ROBO3(4), ROCK2(1), SEMA3A(1), SEMA3B(1), SEMA3C(1), SEMA3E(1), SEMA3F(1), SEMA4A(1), SEMA4B(1), SEMA4F(1), SEMA6A(1), SEMA6B(2), SEMA6C(1), SEMA6D(2), SEMA7A(1), SLIT1(3), SLIT2(3), SLIT3(1), SRGAP1(1), SRGAP2(1) 85317113 103 77 101 34 26 28 6 24 19 0 0.337 1.000 1.000 562 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), ADK(1), ADSL(1), ADSSL1(1), AK7(4), AMPD2(2), CANT1(3), ENPP1(1), ENPP3(2), ENTPD5(1), ENTPD6(1), GART(1), GMPR(1), GMPR2(1), GUCY1A3(1), GUCY2C(2), GUCY2F(2), IMPDH2(1), NT5C(2), NT5E(1), PAICS(1), PDE11A(2), PDE1A(1), PDE1C(1), PDE2A(1), PDE4D(1), PDE7B(1), PDE8A(3), PFAS(1), PKLR(1), POLA1(2), POLD1(1), POLE(1), POLR1A(1), POLR2A(1), POLR2B(1), POLR2G(1), POLR3A(3), POLR3B(1), POLR3GL(1), POLR3K(1), PRIM1(1), PRIM2(2), PRPS1(1), PRPS1L1(1), PRPS2(1), RRM1(1), XDH(2) 70351650 75 66 74 24 28 18 4 12 13 0 0.241 1.000 1.000 563 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 CADM1(1), CD22(2), CD276(1), CD28(1), CD58(1), CDH1(1), CDH15(1), CDH4(4), CDH5(1), CLDN11(1), CLDN14(1), CLDN16(1), CLDN19(1), CNTN2(2), CNTNAP2(2), CTLA4(1), ESAM(1), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(2), HLA-DRA(1), HLA-DRB5(2), HLA-F(2), HLA-G(2), ICAM1(1), ITGA4(1), ITGA8(1), ITGAL(2), ITGB2(1), ITGB7(1), ITGB8(1), JAM2(1), L1CAM(1), MAG(1), NCAM1(2), NEGR1(2), NEO1(2), NLGN1(1), NLGN2(1), NLGN3(3), NRCAM(2), NRXN1(1), NRXN3(1), PTPRC(3), PTPRF(2), PTPRM(2), PVR(2), PVRL3(1), SDC1(1), SELE(3), SELP(1), SELPLG(1), SIGLEC1(1), VCAN(3) 63752914 80 66 79 35 30 14 3 18 15 0 0.697 1.000 1.000 564 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA2(1), ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), ARRB2(1), ATF2(1), CACNB3(1), CNN2(1), CREB3(3), FOS(1), GJA1(1), GNB2(1), GNG12(1), GRK4(1), GUCY1A3(1), IGFBP2(1), IL6(1), ITPR1(2), ITPR2(4), ITPR3(4), NOS1(1), NOS3(3), PDE4D(1), PLCG1(4), PLCG2(4), PRKAR1A(2), PRKCA(1), PRKCH(1), PRKCQ(1), RGS19(1), RGS3(4), RGS6(1), RGS9(1), RLN1(1), RYR1(7), RYR2(10), RYR3(3), TNXB(4), YWHAH(1) 74679350 87 65 85 29 30 18 3 19 17 0 0.440 1.000 1.000 565 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 163 ADRA1B(1), ADRB2(1), AGTR2(1), AVPR1A(2), BRS3(1), CCR10(1), CCR7(1), CHRM1(1), CHRM3(3), CHRM5(1), CMKLR1(1), CXCR4(1), DRD5(3), F2RL1(2), FPR1(1), FSHR(1), GALR1(1), GPR17(1), GPR174(1), GPR35(1), GPR50(2), GPR83(1), GPR85(1), GPR87(1), GRPR(3), HCRTR2(1), HRH1(1), HTR1B(2), HTR1E(1), HTR2A(1), HTR2B(2), HTR4(1), HTR5A(1), MC3R(1), MC4R(1), MC5R(1), MTNR1A(1), NMBR(2), NMUR2(1), NPY1R(1), NPY2R(1), OPRD1(1), OR10A5(1), OR1C1(2), OR1Q1(1), P2RY12(2), P2RY2(1), P2RY6(1), PPYR1(1), PTAFR(1), SSTR2(1), SSTR3(2), SSTR4(5) 52556245 72 61 72 32 30 17 1 17 7 0 0.604 1.000 1.000 566 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA2(1), ACTN3(1), ACTN4(1), DMD(4), MYBPC2(2), MYH3(3), MYH6(2), MYH7(1), MYH8(6), MYOM1(1), NEB(10), TNNI1(1), TNNT1(1), TNNT3(2), TPM1(2), TPM2(1), TPM3(1), TTN(34) 58433085 74 60 73 30 31 15 1 19 8 0 0.702 1.000 1.000 567 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), AKAP3(1), AKAP4(4), AKAP5(1), AKAP6(3), AKAP8(2), AKAP9(4), GNAO1(3), GNB2(1), GNG12(1), ITPR1(2), KRAS(1), NRAS(1), PDE1A(1), PDE1B(1), PDE1C(1), PDE4D(1), PDE7B(1), PDE8A(3), PRKACG(1), PRKAR1A(2), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(1), RRAS(1) 50452271 50 47 50 17 18 8 1 10 13 0 0.536 1.000 1.000 568 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADK(1), ADSL(1), AMPD2(2), CANT1(3), ENPP1(1), ENPP3(2), GART(1), GUCY1A3(1), GUCY2C(2), GUCY2F(2), IMPDH2(1), NT5C(2), NT5E(1), PAICS(1), PDE1A(1), PDE4D(1), PDE6B(3), PDE6C(3), PDE7B(1), PDE8A(3), PFAS(1), PKLR(1), POLD1(1), POLE(1), POLQ(2), POLR2A(1), POLR2B(1), POLR2G(1), PRPS1(1), PRPS1L1(1), PRPS2(1), RRM1(1) 55286989 54 47 54 25 25 15 2 6 6 0 0.768 1.000 1.000 569 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 CAPN11(2), CAPN3(1), DOCK1(1), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(1), ITGA4(1), ITGA5(1), ITGA8(1), ITGAD(1), ITGAE(1), ITGAL(2), ITGAX(1), ITGB2(1), ITGB6(1), ITGB7(1), ITGB8(1), MAP2K3(1), MAP2K6(1), MAPK12(1), MAPK4(1), MAPK7(3), PAK1(1), PAK4(1), PAK6(1), RAC2(1), RAPGEF1(2), ROCK2(1), SHC1(1), TLN1(3), VAV3(8), VCL(1) 57814027 48 43 41 18 13 7 0 14 14 0 0.826 1.000 1.000 570 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(1), CABIN1(2), CREBBP(4), CSNK2A1(1), CTLA4(1), FOS(1), GATA4(1), IL6(1), KPNA5(1), MAPK8(1), MAPK9(1), MYF5(1), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), OPRD1(1), PAK1(1), PTPRC(3), SLA(1), SP3(2), TNF(1), TRPV6(3), VAV1(3), VAV3(8) 39230584 45 41 38 17 12 11 1 6 15 0 0.738 1.000 1.000 571 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(2), ABCA10(1), ABCA12(1), ABCA13(6), ABCA2(1), ABCA3(1), ABCA4(3), ABCA6(2), ABCA7(4), ABCA8(1), ABCB1(3), ABCB10(2), ABCB4(3), ABCB7(1), ABCC10(3), ABCC12(1), ABCC3(1), ABCC9(1), ABCD2(1), ABCG1(1), ABCG4(2), ABCG5(1), ABCG8(1), CFTR(3) 50811373 46 39 46 25 11 13 3 10 9 0 0.928 1.000 1.000 572 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(5), ACSL1(3), ACSL4(1), ACSL6(1), ADIPOR1(1), CD36(1), G6PC(3), G6PC2(1), IRS1(2), IRS4(2), JAK2(1), JAK3(1), MAPK8(1), MAPK9(1), NFKBIA(1), NPY(2), PCK1(1), PPARGC1A(1), PRKAA1(1), PRKCQ(1), PTPN11(5), RXRA(1), RXRG(3), STAT3(1), TNF(1), TRADD(1), TYK2(2) 35856094 45 39 44 19 14 14 0 12 5 0 0.618 1.000 1.000 573 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CDC40(1), CLK4(1), COL2A1(1), CPSF2(1), CSTF1(1), CSTF2(1), CSTF3(1), DDIT3(1), DHX16(1), DHX38(2), FUS(1), LOC440563(1), METTL3(1), PAPOLA(1), POLR2A(1), PRPF18(1), PRPF8(2), PSKH1(1), RNGTT(1), SF3A3(1), SF3B1(2), SNRPB(1), SNRPB2(1), SNRPE(1), SNRPN(1), SPOP(2), SRPK2(1), SRRM1(1), TXNL4A(1), U2AF2(2), XRN2(2) 45547694 37 36 37 12 9 11 1 9 7 0 0.585 1.000 1.000 574 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ABP1(3), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), AOX1(2), CYP1A2(2), CYP2B6(1), CYP2C19(5), CYP2C8(1), CYP3A4(2), CYP3A7(1), CYP4F8(1), DDC(1), ECHS1(1), HADHA(2), TDO2(1), WARS2(1) 23701880 32 28 32 13 15 7 0 5 5 0 0.598 1.000 1.000 575 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACOX3(1), ACSL1(3), ACSL4(1), ACSL6(1), APOA1(1), CD36(1), CYP4A11(1), CYP4A22(1), CYP8B1(1), FADS2(1), GK(1), GK2(3), LPL(1), MMP1(1), NR1H3(1), PCK1(1), PPARG(1), RXRA(1), RXRG(3), SLC27A4(1), UBC(2) 28202668 28 27 28 11 4 12 1 7 4 0 0.571 1.000 1.000 576 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP4(2), CSNK1A1L(1), CSNK1G1(1), CSNK1G2(1), GLI1(1), GLI3(1), HHIP(1), LRP2(8), PRKACG(1), PTCH1(1), RAB23(1), SHH(1), STK36(1), SUFU(1), WNT11(2), WNT16(1), WNT2(1), WNT7A(1), WNT8A(1), WNT9B(1) 26321149 29 25 29 14 12 8 1 3 5 0 0.795 1.000 1.000 577 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPP(4), ALPPL2(2), DDX4(2), DDX51(2), DDX52(1), DDX55(1), DDX56(1), FPGS(2), IFIH1(2), MOV10L1(1), QDPR(1), RAD54L(1), RUVBL2(1), SETX(3), SKIV2L2(1), SPR(1) 27040912 26 24 26 10 9 6 1 5 5 0 0.680 1.000 1.000 578 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 ARSD(1), ARSE(1), CYP11B1(1), HSD3B2(1), PRMT5(2), PRMT8(1), SRD5A1(1), SULT2B1(2), UGT1A1(3), UGT2A3(1), UGT2B10(4), UGT2B11(3), UGT2B28(2), UGT2B4(1), UGT2B7(1) 21639294 25 23 25 10 5 5 1 13 1 0 0.710 1.000 1.000 579 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS2(1), CP(1), EPRS(1), FTH1(1), HCCS(2), PPOX(1), UGT1A1(3), UGT2A3(1), UGT2B10(4), UGT2B11(3), UGT2B28(2), UGT2B4(1), UGT2B7(1) 18203707 22 21 22 10 2 7 0 13 0 0 0.843 1.000 1.000 580 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(3), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH4A1(1), ASL(1), CPS1(2), GLUD1(2), NOS1(1), NOS3(3), RARS(1) 19098778 21 20 21 14 8 5 0 3 5 0 0.960 1.000 1.000 581 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 CALR(1), CIITA(1), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(2), HLA-DRA(1), HLA-DRB5(2), HLA-F(2), HLA-G(2), IFNA21(1), IFNA5(1), KIR2DL1(3), KLRC2(1), RFXANK(1) 19913781 20 20 20 10 4 4 2 7 3 0 0.829 1.000 1.000 582 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(3), AGXT2(1), ALAS2(1), DMGDH(1), GARS(1), GLDC(1), PLCB2(3), PLCG1(4), PLCG2(4), PSPH(1) 18166996 20 19 19 10 8 6 0 4 2 0 0.800 1.000 1.000 583 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(1), ASL(1), ASS1(1), CPS1(2), EPRS(1), GLUD1(2), GLUD2(1), NOS1(1), NOS3(3), RARS(1), RARS2(2) 15521148 16 15 16 10 3 5 0 5 3 0 0.955 1.000 1.000 584 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(2), GPRC5C(1), GPRC5D(2), GRM3(1), GRM4(3), GRM5(1), GRM7(2) 9051312 12 12 12 8 9 1 0 2 0 0 0.891 1.000 1.000 585 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(3), AGXT2(1), ALAS2(1), DMGDH(1), GARS(1), GLDC(1), HSD3B7(1), PHGDH(2), PSPH(1) 18444475 12 12 12 10 3 3 0 5 1 0 0.973 1.000 1.000 586 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 ARSD(1), ARSE(1), CYP11B1(1), HSD3B2(1), SRD5A1(1), UGT1A1(3), UGT2B4(1) 11786478 9 9 9 5 3 1 0 5 0 0 0.867 1.000 1.000 587 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC2(1), ANAPC7(1), CDC16(1), CUL1(1), FBXW7(1), FZR1(1), SKP2(1), SMURF2(1), UBE2D4(1) 17280108 9 9 9 9 1 4 1 3 0 0 0.993 1.000 1.000 588 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1), DCN(1), FMOD(1), KERA(3), LUM(1) 1563894 7 7 7 5 1 3 0 3 0 0 0.889 1.000 1.000 589 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 ARHGDIB(1), CASP1(1), CYCS(1), PRF1(1) 5538024 4 4 4 3 1 1 0 2 0 0 0.934 1.000 1.000 590 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 MYLK(1), PLCB1(2), PRKCA(1) 8878408 4 4 4 4 2 0 0 2 0 0 0.962 1.000 1.000 591 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(1), POLD1(1), PRPS2(1), RRM1(1) 5384326 4 4 4 3 2 2 0 0 0 0 0.838 1.000 1.000 592 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 RELN(4) 6036684 4 4 4 3 1 3 0 0 0 0 0.833 1.000 1.000 593 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(1), POLE(1), POLQ(2) 7174802 4 3 4 5 4 0 0 0 0 0 0.984 1.000 1.000 594 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(1), EIF2AK4(1), EIF2S2(1) 4956168 3 3 3 3 1 0 1 1 0 0 0.939 1.000 1.000 595 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 CYCS(1), FASLG(1), TNF(1) 4880765 3 3 3 4 0 1 0 2 0 0 0.995 1.000 1.000 596 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 IL6(1), STAT3(1), TNF(1) 5237079 3 3 3 3 1 1 0 1 0 0 0.951 1.000 1.000 597 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR2A(1), POLR2B(1), POLR2G(1) 5833305 3 3 3 3 1 2 0 0 0 0 0.903 1.000 1.000 598 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 DNMT1(1), MTNR1A(1), PTAFR(1) 4823811 3 3 3 3 2 1 0 0 0 0 0.929 1.000 1.000 599 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGEF2(2) 6984804 2 2 2 2 0 1 1 0 0 0 0.907 1.000 1.000 600 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 GPR34(1), GPR45(1) 4225350 2 2 2 3 1 1 0 0 0 0 0.945 1.000 1.000 601 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD58(1), IL6(1) 2654615 2 2 2 2 0 0 0 2 0 0 0.951 1.000 1.000 602 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 HLA-DRA(1), IL6(1) 2299642 2 2 2 2 0 0 0 2 0 0 0.952 1.000 1.000 603 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 MAPK8(1), TNFRSF13B(1) 6273334 2 2 2 2 0 2 0 0 0 0 0.893 1.000 1.000 604 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 14 IL6(1) 3504419 1 1 1 4 0 0 0 1 0 0 0.998 1.000 1.000 605 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 14 IL6(1) 2564187 1 1 1 2 0 0 0 1 0 0 0.979 1.000 1.000 606 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 4992904 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 607 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 3754891 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 608 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 311704 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 609 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 219003 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 610 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 1325492 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 611 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 656813 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 612 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 3998853 0 0 0 3 0 0 0 0 0 0 1.000 1.000 1.000 613 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 736382 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 614 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 3758025 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 615 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 2628571 0 0 0 2 0 0 0 0 0 0 1.000 1.000 1.000 616 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 490549 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000