rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(3), GABRA3(2), GABRA4(3), GABRA5(1), GABRA6(3) 3395416 12 12 12 2 5 3 0 4 0 0 0.209 0.000717 0.442 2 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1), IL12B(1), IL18(2) 1280747 4 4 4 1 1 0 1 2 0 0 0.619 0.0113 1.000 3 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT2(1), AGPAT3(1), AGPS(1), ENPP2(2), PAFAH1B1(2), PAFAH1B3(1), PAFAH2(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PLD1(3) 9987119 19 18 19 1 3 5 2 7 2 0 0.0323 0.0115 1.000 4 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACPP(3), ENPP1(1), ENPP3(2), FLAD1(1), TYR(2) 4172365 9 9 9 1 3 3 0 1 2 0 0.206 0.0167 1.000 5 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPP(4), ALPPL2(2), FPGS(2), SPR(1) 2821312 9 8 9 2 3 2 1 1 2 0 0.429 0.0192 1.000 6 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX3(1), FADS2(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4) 4369144 9 9 9 0 1 3 0 3 2 0 0.0742 0.0193 1.000 7 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 20 CFL1(1), LIMK1(3), MAP3K1(2), MYLK(1), NCF2(1), PAK1(1), PDGFRA(7), PLD1(3), TRIO(2), VAV1(3) 13426396 24 23 24 2 7 6 1 4 6 0 0.0219 0.0259 1.000 8 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(2), CDC34(1), CUL1(1), RB1(3), SKP2(1) 3677825 8 8 8 0 0 2 0 1 5 0 0.252 0.0318 1.000 9 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 11 EGF(3), MET(4), PDGFRA(7), PRKCA(1), SH3KBP1(1) 7227860 16 14 16 2 2 5 0 4 5 0 0.168 0.0418 1.000 10 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(1), ANKRD1(1), HBEGF(1), IFRD1(2), IL18(2), IL1R1(1), NR4A3(1) 4628694 9 9 9 1 2 3 0 1 3 0 0.302 0.0449 1.000 11 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 5 PLCB1(2), PLCG1(4), PRKCA(1), VAV1(3) 3899907 10 10 9 2 3 3 0 3 1 0 0.380 0.0608 1.000 12 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F2(3), F5(4), F7(1), FGA(1), FGB(1), FGG(1), PROS1(1) 7048274 12 12 12 1 4 4 0 2 2 0 0.0625 0.0657 1.000 13 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BRAF(3), CREB3(3), MAPK1(1), RAF1(1) 4799126 8 8 8 0 0 2 0 2 4 0 0.222 0.0701 1.000 14 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CDKN1B(1), CUL1(1), RB1(3), SKP2(1), UBE2M(1) 3686822 7 7 7 0 0 2 0 1 4 0 0.218 0.0736 1.000 15 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(1), TAT(1), TYR(2) 2028505 4 4 4 1 2 0 1 1 0 0 0.583 0.0786 1.000 16 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACPP(3), ENPP1(1), ENPP3(2), FLAD1(1), MTMR6(1), TYR(2) 6468112 10 10 10 1 3 4 0 1 2 0 0.147 0.0892 1.000 17 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 LPO(3), MPO(2), TPO(3), TYR(2) 4164396 10 9 10 2 6 2 0 2 0 0 0.267 0.0968 1.000 18 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(1), FHL5(1), FSHR(1), GNAS(3), XPO1(1) 4125185 7 7 7 1 2 1 1 2 1 0 0.468 0.116 1.000 19 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 GABRA1(3), GABRA3(2), GABRA4(3), GABRA5(1), GABRA6(3) 5158397 12 12 12 3 5 3 0 4 0 0 0.384 0.119 1.000 20 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 CYCS(1), SDHA(3), SDHC(1), UQCRC1(1) 2845533 6 5 5 0 2 3 0 1 0 0 0.128 0.120 1.000 21 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(2), PC(1), PDHA1(3), SLC25A1(1) 3999603 7 7 7 1 0 2 0 3 2 0 0.306 0.121 1.000 22 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 14 CDKN1B(1), CDKN2A(1), CFL1(1), MDM2(2), PRB1(2) 3278740 7 6 7 0 0 3 0 2 2 0 0.105 0.121 1.000 23 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), NAT2(2), XDH(2) 3425900 6 6 6 0 4 0 0 1 1 0 0.134 0.123 1.000 24 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(1), CHRNA1(2) 1400897 3 3 3 0 1 1 0 0 1 0 0.300 0.125 1.000 25 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1) 3680157 7 7 7 1 5 0 0 0 2 0 0.240 0.126 1.000 26 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 RB1(3), SP3(2) 2857372 5 5 5 1 0 1 0 0 4 0 0.718 0.126 1.000 27 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 6 EEA1(1), EGF(3), HGS(2), TFRC(2) 4376211 8 7 8 1 3 2 0 2 1 0 0.271 0.128 1.000 28 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 LARS(1), PDHA1(3), PDHA2(2), PDHB(1) 4316140 7 7 7 1 0 4 0 2 1 0 0.287 0.130 1.000 29 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CDC34(1), CUL1(1), FBXW7(1), RB1(3) 3551777 6 6 6 0 1 1 0 0 4 0 0.301 0.133 1.000 30 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IL12B(1), IL15(1), IL16(3), IL18(2), IL6(1), TNF(1) 4265951 9 9 9 2 2 2 1 3 1 0 0.413 0.134 1.000 31 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(1), GNAS(3), PRKAR1A(2) 2849516 6 6 6 1 3 0 0 2 1 0 0.562 0.144 1.000 32 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(2), ENPP1(1), ENPP3(2), NADSYN1(1), NNMT(1), NT5C(2), NT5E(1) 6271908 10 10 10 2 1 6 1 1 1 0 0.264 0.145 1.000 33 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 CHAT(1), PDHA1(3), PDHA2(2) 3014484 6 6 6 1 0 3 0 1 2 0 0.348 0.152 1.000 34 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(1), COQ5(2) 1732532 3 3 3 0 0 2 0 1 0 0 0.387 0.158 1.000 35 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1) 5706969 12 12 12 3 6 1 0 2 3 0 0.292 0.160 1.000 36 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACPP(3), ALPP(4), ALPPL2(2), CYP3A4(2), CYP3A7(1), DHRS2(1), DHRSX(1), PON1(2) 7756665 16 15 16 3 6 3 0 2 5 0 0.208 0.166 1.000 37 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 MAX(3), SP3(2) 2687143 5 5 4 0 2 1 0 1 1 0 0.228 0.167 1.000 38 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1) 2424150 5 5 5 2 1 1 0 2 1 0 0.678 0.183 1.000 39 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 12 ARPC1B(1), PAK1(1), PDGFRA(7) 4140536 9 8 9 2 0 4 0 1 4 0 0.654 0.191 1.000 40 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(2), AGTR2(1), NOS3(3), REN(1) 4301265 7 7 7 1 4 1 0 0 2 0 0.334 0.192 1.000 41 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1) 709762 1 1 1 0 0 0 0 1 0 0 0.818 0.195 1.000 42 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3) 3450254 7 7 7 2 4 1 0 0 2 0 0.427 0.197 1.000 43 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3) 3450254 7 7 7 2 4 1 0 0 2 0 0.427 0.197 1.000 44 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(2), CCNE2(1), CDKN1B(1), CDKN2A(1), PRB1(2) 3867390 7 6 7 0 0 4 0 1 2 0 0.135 0.202 1.000 45 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(4), ACACB(5), ACAT2(1), ACSS1(2), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), LDHA(1), LDHAL6B(1), LDHB(1), PC(1), PCK1(1), PDHA1(3), PDHA2(2), PDHB(1), PKLR(1) 20185247 31 31 31 4 13 9 0 6 3 0 0.0129 0.202 1.000 46 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLUD1(2), GLUD2(1) 1963832 3 3 3 1 0 1 0 2 0 0 0.767 0.204 1.000 47 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(1), IDI1(1) 1355720 2 2 2 0 0 1 0 0 1 0 0.661 0.215 1.000 48 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(1), B3GNT5(2), ST3GAL3(1), ST3GAL4(1) 3100421 5 5 5 0 2 2 0 0 1 0 0.130 0.221 1.000 49 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 LPO(3), MPO(2), TPO(3) 3611032 8 7 8 2 5 2 0 1 0 0 0.376 0.223 1.000 50 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(2), ICAM1(1), ITGA4(1), ITGAL(2), ITGB2(1), SELE(3) 5209546 10 10 9 3 6 3 0 0 1 0 0.315 0.229 1.000 51 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(2) 790850 2 2 2 1 1 0 0 1 0 0 0.845 0.229 1.000 52 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(1), NR3C1(1), PPARG(1), RXRA(1), TNF(1) 2499615 5 5 5 2 0 3 0 2 0 0 0.658 0.243 1.000 53 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 4 EGF(3), ERBB3(1), NRG1(1) 3299667 5 5 5 0 2 1 0 1 1 0 0.301 0.244 1.000 54 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2), PTGS1(1), PTGS2(1) 2299258 4 4 4 1 3 0 0 1 0 0 0.588 0.246 1.000 55 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(2), CCNB1(1), CDKN1B(1), CDKN2A(1), CDKN2C(1), RB1(3) 6920181 9 9 9 0 0 3 0 1 5 0 0.136 0.247 1.000 56 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 16 CSNK2A1(1), FOS(1), MAPK8(1), PLCG1(4), RAF1(1), SHC1(1) 6610587 9 9 8 1 0 6 0 1 2 0 0.169 0.253 1.000 57 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 EPHX2(2), HSD3B7(1) 2068630 3 3 3 1 1 0 0 2 0 0 0.731 0.254 1.000 58 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 HGD(2) 955265 2 2 2 1 0 0 0 1 1 0 0.941 0.254 1.000 59 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADS(2), ECHS1(1), HADHA(2) 2323924 5 5 5 2 1 1 0 1 2 0 0.642 0.282 1.000 60 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ASL(1), CPS1(2), GLUD1(2) 3364346 5 4 5 1 0 0 0 2 3 0 0.813 0.283 1.000 61 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 18 EIF4A1(2), EIF4A2(1), EIF4B(1), EIF4G1(3), EIF4G3(3), MKNK1(1), TSC1(1), TSC2(2) 9931741 14 13 14 1 3 6 0 3 2 0 0.0763 0.285 1.000 62 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), HLA-DRA(1) 1022309 2 2 2 0 1 0 0 1 0 0 0.573 0.285 1.000 63 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(1), HDC(2), TH(1) 2613399 4 4 4 1 2 1 0 1 0 0 0.510 0.304 1.000 64 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 HK1(3), PFKL(1), PGK1(1), PKLR(1) 4009994 6 6 6 0 2 3 0 0 1 0 0.0839 0.315 1.000 65 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 30 CYP1A2(2), CYP2C8(1), CYP3A4(2), CYP3A7(1), HSD3B7(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4) 9854519 14 14 14 2 4 3 0 5 2 0 0.218 0.323 1.000 66 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 DPYS(2), ENPP1(1), ENPP3(2), ILVBL(1), PANK2(1), PANK4(1), VNN1(1) 7451094 9 9 9 0 2 1 0 1 5 0 0.172 0.332 1.000 67 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(1), CA1(1), CA12(1), CA5A(1), CPS1(2), GLUD1(2), HAL(1) 8183484 9 9 9 1 2 1 1 3 2 0 0.290 0.335 1.000 68 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(1), GLUD1(2) 2380799 3 3 3 1 0 0 0 3 0 0 0.811 0.337 1.000 69 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(1), IDI1(1) 1820386 2 2 2 0 0 1 0 0 1 0 0.660 0.342 1.000 70 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 TAT(1) 1134964 1 1 1 1 0 0 1 0 0 0 0.909 0.354 1.000 71 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 GAD2(1), GGT1(2) 2482497 3 3 3 0 2 1 0 0 0 0 0.290 0.356 1.000 72 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(1), FOS(1), JAK2(1), MAPK8(1), PLCG1(4), RAF1(1), SHC1(1), STAT5B(1) 9265220 11 11 10 1 0 6 0 2 3 0 0.111 0.359 1.000 73 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(4), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), LDHA(1), LDHB(1), PC(1), PCK1(1), PDHA1(3), PDHA2(2), PDHB(1), PKLR(1) 15944748 23 23 23 3 7 9 0 4 3 0 0.0327 0.359 1.000 74 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 CHAT(1), DBH(1), DDC(1), GAD2(1), HDC(2), PAH(1), TH(1) 6224415 8 8 8 1 4 1 0 1 2 0 0.242 0.359 1.000 75 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CXCR4(1), FOS(1), MAPK8(1), PLCG1(4), PRKCA(1), PTK2B(1) 5942948 9 9 8 2 1 6 1 0 1 0 0.303 0.361 1.000 76 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 AGPAT2(1), AGPAT3(1), AGPS(1), CHAT(1), DGKA(1), DGKD(2), DGKH(1), DGKQ(1), GNPAT(1), LGALS13(2), LYPLA1(1), PAFAH1B1(2), PAFAH2(1), PLA2G3(1), PLA2G4A(4), PLCB2(3), PLCG1(4), PLCG2(4) 21556210 32 31 31 4 10 10 1 5 6 0 0.0291 0.362 1.000 77 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(3), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH3B2(1), ALDH7A1(1), CNDP1(1), DDC(1), FTCD(3), HAL(1), HARS(1), HDC(2), PRMT5(2), PRMT8(1), PRPS1(1), PRPS2(1) 17087446 25 25 25 4 14 4 2 2 3 0 0.0373 0.377 1.000 78 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 20 CSNK2A1(1), FOS(1), JAK2(1), PLCG1(4), PRKCA(1), RAF1(1), RASA1(2), SHC1(1), STAT3(1), STAT5B(1) 11274022 14 14 13 2 2 5 0 3 4 0 0.191 0.380 1.000 79 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 26 BRAF(3), ERBB2(1), ERBB4(1), ETS1(1), ETV6(2), FMN2(2), KRAS(1), MAPK1(1), NOTCH2(5), NOTCH3(4), NOTCH4(5), PIWIL2(2), PIWIL3(1), RAF1(1), SOS2(1), SPIRE1(1) 19707474 32 31 32 5 10 7 1 7 6 1 0.0620 0.382 1.000 80 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 11 CDC25B(1), MYT1(2), RB1(3), WEE1(1), YWHAH(1) 7210131 8 8 8 0 1 0 0 0 7 0 0.273 0.386 1.000 81 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 HLA-DRA(1), IL12B(1), IL15(1), IL6(1), PDGFA(1), TNF(1) 5660428 6 6 6 1 1 2 1 2 0 0 0.361 0.390 1.000 82 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 DPYS(2), ENPP1(1), ENPP3(2), PANK2(1), PANK4(1) 6002900 7 7 7 0 2 1 0 0 4 0 0.247 0.391 1.000 83 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 11 GH1(1), GHR(1), IGF1R(2), SHC1(1) 4117537 5 5 5 0 0 2 0 2 1 0 0.204 0.405 1.000 84 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(1), GALNT4(1), GALNT6(1), ST3GAL1(1), ST3GAL4(1), WBSCR17(4) 6220936 9 9 9 2 4 1 1 2 1 0 0.451 0.421 1.000 85 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 FUT8(1), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1) 3403392 4 4 4 1 2 1 1 0 0 0 0.541 0.422 1.000 86 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 15 ADRB2(1), ANXA1(2), GNAS(3), NOS3(3), NR3C1(1) 6126607 10 10 10 2 5 2 0 1 2 0 0.330 0.427 1.000 87 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(1), ADRB2(1), CFTR(3), GNAS(3), PRKACG(1), PRKAR1A(2) 5651014 11 11 11 3 4 3 0 2 2 0 0.577 0.428 1.000 88 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(1), FUT5(1), ST3GAL3(1) 2187968 3 3 3 0 1 1 0 0 1 0 0.425 0.430 1.000 89 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ADCY1(1), CCNB1(1), GNAI1(3), GNAS(3), MAPK1(1), MYT1(2), PRKACG(1), PRKAR1A(2), RPS6KA1(1) 8874125 15 15 15 3 3 3 0 4 5 0 0.426 0.431 1.000 90 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 UXS1(2) 1644272 2 2 2 1 0 1 0 0 1 0 0.900 0.432 1.000 91 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR2(2), PDE1A(1), PDE1B(1), PLCB1(2), PLCB2(3) 4807619 9 9 9 3 3 2 0 2 2 0 0.632 0.453 1.000 92 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(2), CYP4F3(4), GGT1(2), LPO(3), LTA4H(1), MPO(2), PLA2G3(1), PLA2G4A(4), PTGES2(1), PTGS1(1), PTGS2(1), TPO(3) 12053396 25 24 25 5 10 5 0 6 4 0 0.111 0.458 1.000 93 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 24 CSNK2A1(1), FOS(1), MAP3K1(2), MAPK8(1), PDGFA(1), PDGFRA(7), PLCG1(4), PRKCA(1), RAF1(1), RASA1(2), SHC1(1), SRF(1), STAT3(1) 13429390 24 22 23 5 4 10 0 3 7 0 0.249 0.463 1.000 94 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(1), CDC25B(1), SHH(1), XPO1(1) 3734420 4 4 4 0 1 3 0 0 0 0 0.205 0.464 1.000 95 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 DLG4(1), F2(3), F2RL1(2), MAP2K5(1), MAPK1(1), MAPK7(3), MAPK8(1), PLD1(3), RAF1(1), RASAL1(1), TEC(1), VAV1(3) 11848811 21 19 21 4 5 5 1 6 4 0 0.177 0.471 1.000 96 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 9 ACLY(2), ACO1(1), ACSS1(2) 5022664 5 5 5 1 1 1 0 2 1 0 0.472 0.477 1.000 97 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(2) 2091986 2 2 2 1 0 2 0 0 0 0 0.739 0.478 1.000 98 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(1), FUCA1(1), FUCA2(2), HEXA(1), LCT(2), MAN2C1(1), NEU1(1), NEU2(2) 7140484 11 11 11 3 3 2 1 3 2 0 0.545 0.483 1.000 99 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 LPO(3), MPO(2), MTHFR(1), TPO(3) 4999800 9 8 9 2 5 2 0 2 0 0 0.341 0.485 1.000 100 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 CREBBP(4), PRF1(1) 4558722 5 5 5 1 2 1 0 1 1 0 0.600 0.485 1.000 101 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(2), APOBEC4(1) 3154212 3 3 3 1 0 1 0 1 1 0 0.703 0.488 1.000 102 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 GNAS(3), PRKACG(1), PRKAR1A(2), PRKCA(1) 4147641 7 7 7 2 3 0 0 2 2 0 0.792 0.498 1.000 103 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(1), DDIT3(1), MAP2K6(1), MAP3K1(2), MAP3K5(2), MAPKAPK5(2), MAX(3), MKNK1(1), PLA2G4A(4), RIPK1(1), SHC1(1), TGFBR1(1), TRADD(1) 15799654 21 20 20 3 4 9 0 5 3 0 0.106 0.503 1.000 104 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 LPO(3), MPO(2), TPO(3) 5090866 8 7 8 2 5 2 0 1 0 0 0.368 0.504 1.000 105 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 31 APC(1), AR(1), BRAF(3), DAG1(1), GNAI1(3), ITPR1(2), ITPR2(4), ITPR3(4), MAPK1(1), PHKA2(2), PITX2(1), PTX3(1), RAF1(1) 20294428 25 25 25 3 4 8 1 8 4 0 0.0685 0.510 1.000 106 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), HLA-DRA(1) 1711473 2 2 2 0 1 0 0 1 0 0 0.584 0.511 1.000 107 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 20 ADCY1(1), BAX(1), CSF2RB(1), IGF1R(2), KIT(2), PRKACG(1), PRKAR1A(2), YWHAH(1) 7836161 11 10 11 2 2 1 0 3 5 0 0.443 0.515 1.000 108 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 MARCKS(1), NFATC1(1), NFATC2(2), NFATC4(1), PLCG1(4), PRKCA(1), SP3(2) 9029438 12 12 11 2 3 4 0 1 4 0 0.264 0.520 1.000 109 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 HLA-DRA(1) 1311478 1 1 1 1 0 0 0 1 0 0 0.945 0.520 1.000 110 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 15 MAPK1(1), MAPK7(3), PLCG1(4), RPS6KA1(1), SHC1(1) 6544260 10 9 9 2 0 5 0 3 2 0 0.410 0.524 1.000 111 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(2), ACE2(1), AGTR2(1), CMA1(1), CTSG(1), ENPEP(4), NLN(1), REN(1), THOP1(1) 9136516 13 13 13 3 4 3 0 3 3 0 0.359 0.524 1.000 112 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 17 CSNK2A1(1), FOS(1), IGF1R(2), IRS1(2), MAPK8(1), RAF1(1), RASA1(2), SHC1(1), SRF(1) 8545865 12 12 12 3 1 5 0 2 4 0 0.399 0.525 1.000 113 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT2(1) 1454369 1 1 1 0 0 0 0 1 0 0 0.819 0.532 1.000 114 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 SNCA(1), SNCAIP(1), UBE2G2(1) 2775440 3 3 3 0 3 0 0 0 0 0 0.282 0.533 1.000 115 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GGT1(2) 1793900 2 2 2 0 1 1 0 0 0 0 0.440 0.542 1.000 116 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(4), PRKCA(1), PTK2B(1) 2902475 7 7 6 3 2 4 0 0 1 0 0.636 0.551 1.000 117 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 C1GALT1(1), GALNT1(1), GALNT14(1), GALNT4(1), GALNT5(1), GALNT6(1), GALNTL1(1), GALNTL4(1), GALNTL5(1), OGT(5), ST3GAL1(1), ST6GALNAC1(1), WBSCR17(4) 13919571 20 20 20 4 5 5 1 5 4 0 0.325 0.555 1.000 118 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 UXS1(2) 2097000 2 2 2 1 0 1 0 0 1 0 0.901 0.555 1.000 119 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(1), PLCB1(2) 3080286 3 3 3 1 0 0 0 2 1 0 0.755 0.556 1.000 120 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(1) 912723 1 1 1 0 0 0 0 1 0 0 0.810 0.562 1.000 121 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 FOS(1), MAPK1(1), MAPK8(1), PRKCA(1) 3834844 4 4 4 1 1 3 0 0 0 0 0.455 0.563 1.000 122 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1) 1686724 1 1 1 0 0 0 0 1 0 0 0.818 0.568 1.000 123 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(1), PRKCA(1) 2138681 2 2 2 1 1 0 0 1 0 0 0.802 0.569 1.000 124 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(2), ICAM1(1), ITGAL(2), ITGB2(1), SELE(3) 4479835 9 9 8 4 6 2 0 0 1 0 0.537 0.570 1.000 125 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 20 CDKN1B(1), MAPK1(1), NFKBIA(1), PAK1(1), RAF1(1), RB1(3) 7090736 8 8 8 2 0 1 0 0 7 0 0.645 0.573 1.000 126 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(3), LCT(2), PYGL(1) 5792937 6 6 6 1 2 2 0 0 2 0 0.257 0.575 1.000 127 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), MAP3K1(2), MAP3K5(2), MAPK8(1), NFKBIA(1), TNFRSF9(2), TNFSF9(1) 8327115 10 10 10 2 2 4 0 0 4 0 0.396 0.581 1.000 128 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 NR1H3(1), RXRA(1) 2340728 2 2 2 1 0 1 1 0 0 0 0.777 0.581 1.000 129 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG5(3), IFNA21(1), IFNA5(1), PIK3R4(1), PRKAA1(1), ULK2(1) 9096352 8 8 8 1 1 3 0 2 2 0 0.222 0.585 1.000 130 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 14 MAP2K3(1), MAP2K6(1), MAP3K1(2), MAPK1(1), RB1(3) 6749635 8 8 8 2 2 2 0 0 4 0 0.561 0.586 1.000 131 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CFL1(1) 1670598 1 1 1 0 0 0 0 0 1 0 0.659 0.593 1.000 132 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 33 BRAF(3), DAG1(1), ITPR1(2), ITPR2(4), ITPR3(4), MAPK1(1), PI3(1), PITX2(1), PLCB1(2), PLCB2(3), PLCB4(1), RAF1(1), SHC1(1), SOS2(1), STAT3(1) 24091490 27 27 27 3 6 8 1 10 2 0 0.0311 0.597 1.000 133 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST3A1(1), XYLT1(2) 2861050 3 3 3 0 1 2 0 0 0 0 0.262 0.598 1.000 134 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST3A1(1), XYLT1(2) 2861050 3 3 3 0 1 2 0 0 0 0 0.262 0.598 1.000 135 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(2), ICAM1(1), ITGA4(1), ITGAL(2), ITGB2(1), SELE(3), SELP(1) 6871726 11 11 10 4 6 3 0 1 1 0 0.429 0.605 1.000 136 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(3), CR2(2), HLA-DRA(1), ICAM1(1), ITGAL(2), ITGB2(1), PTPRC(3) 6542998 13 12 13 4 7 2 0 2 2 0 0.373 0.605 1.000 137 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 HLA-DRA(1), PTPRC(3), ZAP70(2) 3895662 6 6 6 2 2 2 0 2 0 0 0.642 0.607 1.000 138 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST3GAL1(1), ST3GAL4(1) 2438625 2 2 2 1 1 0 1 0 0 0 0.859 0.612 1.000 139 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSS(1), TNF(1), XDH(2) 4275718 4 4 4 1 2 1 0 0 1 0 0.493 0.615 1.000 140 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 FDPS(1), IDI1(1), MVD(1), NSDHL(2) 5685804 5 5 5 0 2 1 0 1 1 0 0.257 0.620 1.000 141 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 CHPF(1), CHST11(1), CHST13(1), CHSY1(1), DSE(1), XYLT1(2) 6090316 7 7 7 1 3 2 0 2 0 0 0.245 0.621 1.000 142 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(4), MAP2(2), PRKACG(1) 7821214 7 7 7 0 0 2 0 0 5 0 0.332 0.622 1.000 143 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 7 SDHA(3) 3710442 3 3 2 0 1 2 0 0 0 0 0.301 0.633 1.000 144 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(4), PRKAA1(1) 6227744 5 5 5 1 3 2 0 0 0 0 0.422 0.633 1.000 145 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(1), ACACA(4), ACACB(5), ACAT2(1), ACSS1(2), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH6A1(1), ALDH7A1(1), ECHS1(1), HADHA(2), LDHA(1), LDHAL6B(1), LDHB(1) 17105171 27 26 27 5 13 5 0 6 3 0 0.0834 0.638 1.000 146 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25B(1), WEE1(1) 2943558 2 2 2 1 1 0 0 0 1 0 0.942 0.653 1.000 147 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 15 BAX(1), MDM2(2), RB1(3) 7439297 6 6 6 0 0 1 0 1 4 0 0.261 0.657 1.000 148 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 CDC25B(1), MYT1(2), WEE1(1), YWHAH(1) 5927391 5 5 5 0 1 0 0 0 4 0 0.409 0.669 1.000 149 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(3) 3629332 3 3 3 0 1 2 0 0 0 0 0.313 0.674 1.000 150 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 HEXA(1), IDS(1), LCT(2), NAGLU(2) 6232259 6 6 6 1 2 2 0 0 2 0 0.391 0.674 1.000 151 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 14 CD28(1), CTLA4(1), HLA-DRA(1) 3357228 3 3 3 1 2 0 0 1 0 0 0.727 0.675 1.000 152 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 9 EGF(3), MAP3K1(2), NCOR2(3), RXRA(1), THRA(1) 6333818 10 10 10 3 4 3 0 1 2 0 0.525 0.677 1.000 153 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GGT1(2) 2376239 2 2 2 0 1 1 0 0 0 0 0.449 0.679 1.000 154 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), BAG4(1), CRADD(1), LMNA(1), LMNB2(1), MADD(1), MAP3K1(2), MAPK8(1), PAK1(1), PRKDC(3), RB1(3), RIPK1(1), SPTAN1(2), TNF(1), TRADD(1) 16624676 21 19 21 3 6 5 1 3 6 0 0.125 0.681 1.000 155 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SRP72(1), SRPR(1) 3246178 2 2 2 1 2 0 0 0 0 0 0.815 0.682 1.000 156 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(2), DAG1(1), ITPR1(2), ITPR2(4), ITPR3(4), NFKBIA(1), PDK1(2), PHKA2(2), PITX2(1), PLD1(3) 19345027 22 22 22 3 6 4 2 9 1 0 0.0903 0.682 1.000 157 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATR(1), CCNB1(1), CDC25B(1), CDC34(1), CHEK2(1), MDM2(2), MYT1(2), PRKDC(3), RPS6KA1(1), WEE1(1), YWHAH(1) 17566222 15 15 15 1 2 3 1 4 5 0 0.110 0.685 1.000 158 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 IL6(1), LPL(1) 2295534 2 2 2 0 0 0 0 2 0 0 0.699 0.687 1.000 159 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 23 CSNK2A1(1), EGF(3), FOS(1), MAP3K1(2), MAPK8(1), PLCG1(4), PRKCA(1), RAF1(1), RASA1(2), SHC1(1), SRF(1), STAT3(1) 13391750 19 18 18 4 4 8 0 3 4 0 0.242 0.689 1.000 160 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFS1(1), NDUFV2(1) 3003480 2 2 2 0 0 0 0 1 1 0 0.832 0.689 1.000 161 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 ABAT(1), ACADS(2), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ECHS1(1), GAD2(1), HADHA(2), L2HGDH(1), PDHA1(3), PDHA2(2), PDHB(1) 11125911 22 21 22 6 7 5 0 4 6 0 0.205 0.690 1.000 162 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 12 GH1(1), GHR(1), NFKBIA(1), YWHAH(1) 4442296 4 4 4 1 0 1 0 1 2 0 0.661 0.696 1.000 163 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B4GALNT1(1), HEXA(1), LCT(2), SLC33A1(1), ST3GAL1(1), ST6GALNAC3(1), ST8SIA5(1) 7099090 8 8 8 2 4 0 1 1 2 0 0.597 0.704 1.000 164 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 13 CDKN2A(1), MDM2(2), POLR1A(1), RB1(3), TBX2(1) 6766464 8 8 8 2 0 2 0 2 4 0 0.693 0.706 1.000 165 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 36 EEF1A2(1), EEF1D(2), EIF2AK3(1), EIF2B4(1), EIF2S2(1), EIF4A1(2), EIF4A2(1), EIF4G1(3), EIF4G3(3), GSPT2(2), KIAA0664(5), PABPC1(2) 18794112 24 21 24 4 6 4 2 5 7 0 0.161 0.706 1.000 166 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 25 ACLY(2), ACO1(1), IDH3B(1), OGDHL(1), PC(1), PCK1(1), SDHA(3), SDHC(1) 12154246 11 11 10 1 3 5 0 1 2 0 0.0683 0.709 1.000 167 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS2(1), PPOX(1) 3284851 2 2 2 1 0 1 0 1 0 0 0.805 0.709 1.000 168 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 LDHA(1), LDHB(1), NCL(1) 3852719 3 3 3 0 0 1 0 1 1 0 0.562 0.710 1.000 169 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 ECHS1(1), HADHA(2) 2085196 3 3 3 3 0 1 0 1 1 0 0.924 0.712 1.000 170 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 18 ACO1(1), IDH3B(1), PC(1), PCK1(1), SDHA(3) 8166719 7 7 6 0 1 5 0 0 1 0 0.0619 0.713 1.000 171 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 LDHA(1), LDHB(1) 2949177 2 2 2 0 0 1 0 1 0 0 0.563 0.714 1.000 172 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP9(1), RECK(1), TIMP4(1) 3249643 3 3 3 1 2 0 0 0 1 0 0.644 0.719 1.000 173 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 HEXA(1), HYAL1(1), IDS(1), LCT(2), NAGLU(2), SPAM1(1) 8863126 8 8 8 1 3 2 0 1 2 0 0.278 0.720 1.000 174 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 P2RY2(1), P2RY6(1) 2572781 2 2 2 1 1 1 0 0 0 0 0.716 0.722 1.000 175 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CD28(1), CTLA4(1), DAG1(1), FBXW7(1), LAT(1), MAPK1(1), NCK1(1), NFAT5(2), NFKBIA(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PLCG1(4), PTPRC(3), RAF1(1), RASGRP2(1), RASGRP4(1), SOS2(1), VAV1(3), ZAP70(2) 24023237 30 26 29 3 9 11 0 4 6 0 0.00813 0.723 1.000 176 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 MST1(3), TNF(1) 2826765 4 4 4 2 1 2 0 0 1 0 0.701 0.725 1.000 177 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(1), CYP11B1(1), HSD3B2(1) 3988391 3 3 3 0 1 0 0 2 0 0 0.478 0.734 1.000 178 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(1), CYP11B1(1), HSD3B2(1) 3988391 3 3 3 0 1 0 0 2 0 0 0.478 0.734 1.000 179 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CREBBP(4), GNAS(3), HLA-DRA(1), PRKACG(1), PRKAR1A(2), PTPRC(3), ZAP70(2) 9917795 17 16 17 4 6 3 0 5 3 0 0.484 0.735 1.000 180 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CREBBP(4), GNAS(3), HLA-DRA(1), PRKACG(1), PRKAR1A(2), PTPRC(3), ZAP70(2) 9917795 17 16 17 4 6 3 0 5 3 0 0.484 0.735 1.000 181 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 LDHA(1), LDHAL6B(1), LDHB(1), SULT1C2(1) 5405420 4 4 4 1 1 1 0 1 1 0 0.676 0.743 1.000 182 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(1), GNAS(3), PRKAA1(1), PRKACG(1), PRKAR1A(2) 6623564 8 8 8 2 4 0 0 2 2 0 0.689 0.744 1.000 183 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(3), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH3B2(1), CNDP1(1), DDC(1), HAL(1), HARS(1), HDC(2), PRPS1(1), PRPS2(1) 10532488 19 18 19 5 11 3 1 2 2 0 0.209 0.745 1.000 184 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 FBP2(1), G6PC(3), HK1(3), HK3(1), LDHA(1), LDHAL6B(1), LDHB(1), PC(1), PCK1(1), PDHA1(3), PDHA2(2), PDHB(1), PFKL(1), PGAM2(1), PGK1(1), PKLR(1) 18321219 23 22 23 3 6 11 0 4 2 0 0.0208 0.746 1.000 185 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1) 1679431 1 1 1 1 0 1 0 0 0 0 0.890 0.751 1.000 186 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 IFNGR2(1), JAK2(1), NFKBIA(1), RB1(3), TNF(1) 7474957 7 7 7 2 0 1 0 0 6 0 0.693 0.752 1.000 187 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD28(1) 1382645 1 1 1 1 1 0 0 0 0 0 0.903 0.753 1.000 188 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 29 IDH3B(1), PC(1), PDHA1(3), PDHA2(2), PDHB(1), PDK1(2), PDK3(1), SDHA(3), SDHC(1) 11880539 15 13 14 3 2 6 0 4 3 0 0.199 0.760 1.000 189 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(1), COL4A4(1), COL4A5(3), COL4A6(3), F2(3), F5(4), F8(3), FGA(1), FGB(1), FGG(1), KLKB1(3), PROS1(1), SERPING1(2) 19133764 27 26 27 6 10 8 1 3 5 0 0.104 0.762 1.000 190 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(2), PRKACG(1) 4350880 3 3 3 1 0 1 0 1 1 0 0.819 0.765 1.000 191 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), RIPK1(1), TNF(1), TRADD(1) 3632122 4 4 4 2 1 1 0 1 1 0 0.818 0.766 1.000 192 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 10 PLCG1(4), PRKCA(1), SHC1(1) 5075677 6 6 5 2 1 3 0 1 1 0 0.639 0.766 1.000 193 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 HEXA(1), ST3GAL1(1), ST3GAL4(1) 4366757 3 3 3 1 1 0 1 0 1 0 0.792 0.769 1.000 194 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(1), CDC25B(1), PRKCA(1) 3971069 3 3 3 1 2 1 0 0 0 0 0.600 0.773 1.000 195 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADS(2), ACADVL(1), ACSL1(3), ACSL4(1), HADHA(2), PECR(1) 7247921 10 10 10 3 1 3 0 2 4 0 0.578 0.775 1.000 196 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 FARS2(2), PAH(1), TAT(1) 3575269 4 4 4 2 1 1 1 0 1 0 0.812 0.776 1.000 197 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(1), JAK2(1), TYK2(2) 4519814 5 5 5 2 1 0 1 0 3 0 0.716 0.777 1.000 198 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(1), JAK2(1), TYK2(2) 4519814 5 5 5 2 1 0 1 0 3 0 0.716 0.777 1.000 199 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS2(1), DHRSX(1), HSD3B7(1), PON1(2) 3872099 5 5 5 2 1 1 0 1 2 0 0.782 0.780 1.000 200 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 DHRS2(1), DHRSX(1), PRMT5(2), PRMT8(1) 6472756 5 5 5 0 1 3 1 0 0 0 0.140 0.787 1.000 201 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 IARS2(1), ILVBL(1), LARS(1), PDHA1(3), PDHA2(2), PDHB(1) 8019112 9 9 9 2 0 4 0 3 2 0 0.440 0.787 1.000 202 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(4), ACACB(5), FASN(1), OXSM(1) 6885313 11 11 11 4 5 3 0 1 2 0 0.524 0.792 1.000 203 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 FDPS(1), IDI1(1), MVD(1) 4771411 3 3 3 0 0 1 0 1 1 0 0.550 0.796 1.000 204 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 HK1(3), HK3(1), PGM3(1) 4410998 5 5 5 2 0 3 0 1 1 0 0.626 0.798 1.000 205 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 CREB3(3), IL1R1(1), MAP2K3(1), MAP2K6(1), MAP3K10(1), MAP3K4(2), MAP3K5(2), MAPK1(1), MAPK12(1), MAPKAPK5(2), MKNK1(1), SRF(1) 14388816 17 17 17 4 1 7 0 5 4 0 0.496 0.800 1.000 206 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(1) 1627024 1 1 1 0 1 0 0 0 0 0 0.612 0.800 1.000 207 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 RAB27A(1) 1818191 1 1 1 0 1 0 0 0 0 0 0.642 0.802 1.000 208 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 HK1(3), HK3(1), ISYNA1(1), PGM3(1) 5043619 6 6 6 2 0 4 0 1 1 0 0.507 0.802 1.000 209 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 GGT1(2), MARS2(1), SCLY(1) 5336322 4 4 4 1 1 2 1 0 0 0 0.464 0.802 1.000 210 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(2), ATP6V1C2(1), ATP6V1D(1), ATP7A(1), COX7B(1), NDUFS1(1), NDUFV2(1), SDHA(3), UQCRC1(1), UQCRH(1) 16441971 13 13 12 0 4 5 0 3 1 0 0.0172 0.807 1.000 211 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(1), CREB3(3), DAG1(1), FOS(1), MAPK1(1), MAPK8(1), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1) 12366981 11 11 11 0 1 4 0 3 3 0 0.0750 0.807 1.000 212 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CYP11A1(1), HSD3B2(1) 2975165 2 2 2 1 1 0 0 1 0 0 0.875 0.808 1.000 213 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(1), PRKCA(1) 3885763 2 2 2 1 1 0 0 1 0 0 0.823 0.808 1.000 214 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 15 AGTR2(1), EGF(3), FOS(1), PLCG1(4), PRKCA(1) 7703232 10 9 9 3 3 5 0 1 1 0 0.461 0.809 1.000 215 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR2(1), JAK2(1) 3515158 2 2 2 2 0 0 0 0 2 0 0.965 0.812 1.000 216 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(3) 2604049 3 3 3 2 2 1 0 0 0 0 0.806 0.812 1.000 217 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(1), ACAD9(1), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), DHRS2(1), DHRSX(1), ESCO2(1) 10743125 10 10 10 2 2 2 0 4 2 0 0.406 0.814 1.000 218 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(2), PAH(1), TAT(1) 3748069 4 4 4 2 1 1 1 0 1 0 0.819 0.815 1.000 219 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(1), CA1(1), CA12(1), CA5A(1), CPS1(2), GLUD1(2), GLUD2(1), HAL(1) 9149707 10 10 10 3 2 2 1 3 2 0 0.580 0.816 1.000 220 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 MAP2K3(1), MAP3K1(2), MAPK1(1), MAPK8(1), PAK1(1), PLCG1(4), PRKCA(1), PTK2B(1), RAF1(1), SHC1(1) 12303490 14 14 13 3 3 7 0 1 3 0 0.249 0.818 1.000 221 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2E1(1), GTF2H4(1), GTF2IRD1(1), TAF1(4), TAF1L(2), TAF2(1), TAF4(1), TAF6(1), TAF9B(1), TBPL2(1) 15500100 14 14 14 2 5 3 0 4 2 0 0.182 0.822 1.000 222 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(1), FOS(1), JAK2(1), RAF1(1), SHC1(1), STAT5B(1) 7612079 6 6 6 1 0 1 0 2 3 0 0.485 0.824 1.000 223 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(1), ADRB2(1), GNAS(3), PLCE1(3), PRKACG(1), PRKAR1A(2), RAP2B(1) 6371572 12 12 12 4 4 2 0 3 3 0 0.763 0.829 1.000 224 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CSNK2A1(1), FOS(1), IL6(1), IL6ST(2), JAK2(1), JAK3(1), RAF1(1), SHC1(1), SRF(1), STAT3(1) 9789152 11 11 11 3 1 3 0 4 3 0 0.498 0.829 1.000 225 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHA4(3), L1CAM(1), SELP(1) 6795425 5 5 5 1 2 1 0 2 0 0 0.538 0.830 1.000 226 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), UBE2G2(1), UBE2M(1) 4537963 3 3 3 1 1 1 0 0 1 0 0.813 0.830 1.000 227 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(2), ANXA2(2), ANXA3(1), ANXA6(1), CYP11A1(1), PLA2G4A(4), PTGS1(1), PTGS2(1) 8878976 13 13 13 4 4 3 1 4 1 0 0.459 0.830 1.000 228 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMPR1B(1) 2711112 1 1 1 2 0 0 0 0 1 0 1.000 0.831 1.000 229 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 25 ACOT11(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), DHRS2(1), DHRSX(1), ECHS1(1), ESCO2(1), HADHA(2) 12865657 14 14 14 3 7 2 0 1 4 0 0.254 0.831 1.000 230 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 DAG1(1) 2626253 1 1 1 0 0 1 0 0 0 0 0.655 0.838 1.000 231 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 EIF2S2(1), NFKBIA(1) 3864581 2 2 2 1 0 0 0 1 1 0 0.819 0.839 1.000 232 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(1) 2116549 1 1 1 0 1 0 0 0 0 0 0.682 0.843 1.000 233 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 18 CSNK2A1(1), FOS(1), IRS1(2), MAPK8(1), RAF1(1), RASA1(2), SHC1(1), SRF(1) 8853828 10 10 10 3 1 4 0 2 3 0 0.562 0.847 1.000 234 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), FAF1(1), LMNA(1), LMNB2(1), MAP3K1(2), MAPK8(1), PAK1(1), PRKDC(3), RB1(3), SPTAN1(2) 17421833 16 15 16 2 3 4 1 2 6 0 0.178 0.850 1.000 235 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(3), BAX(1), MAPK8(1), MDM2(2) 8600415 7 7 7 2 1 2 1 1 2 0 0.550 0.850 1.000 236 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), ECHS1(1), HADHA(2), HSD17B4(2) 3650855 6 6 6 3 0 2 0 2 2 0 0.836 0.852 1.000 237 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 24 ATR(1), CCNA1(2), CDKN1B(1), CDKN2A(1), RB1(3), SKP2(1) 12640102 9 9 9 1 1 1 0 2 5 0 0.430 0.856 1.000 238 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CRADD(1), MAP2K3(1), MAP2K6(1), MAP3K1(2), MAPK8(1), NFKBIA(1), RIPK1(1), TANK(2), TNF(1), TRADD(1) 10446813 12 12 12 3 5 4 0 0 3 0 0.308 0.858 1.000 239 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 PTK2B(1), SHC1(1) 3807867 2 2 2 1 0 1 0 1 0 0 0.813 0.859 1.000 240 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASDHPPT(1) 2035737 1 1 1 0 0 0 0 0 1 0 0.719 0.861 1.000 241 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 INPP4B(1), INPPL1(1), OCRL(2), PIK3C2B(1), PIK3CG(2), PLCB1(2), PLCB2(3), PLCB4(1), PLCG1(4), PLCG2(4) 18343144 21 20 20 4 7 7 1 5 1 0 0.160 0.864 1.000 242 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 16 EIF2S2(1), IGF1R(2), INPPL1(1) 6494197 4 4 4 1 0 2 0 1 1 0 0.516 0.865 1.000 243 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(1) 2647639 1 1 1 1 0 1 0 0 0 0 0.880 0.865 1.000 244 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 18 IL18(2), KLRC2(1), LAT(1), PAK1(1), PTK2B(1), VAV1(3) 6396362 9 8 9 3 3 3 0 2 1 0 0.571 0.867 1.000 245 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR6(1) 2763690 1 1 1 0 0 1 0 0 0 0 0.676 0.869 1.000 246 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT2(1) 3086050 1 1 1 0 0 0 0 1 0 0 0.823 0.871 1.000 247 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 BAX(1), CASP8AP2(1) 4641159 2 2 2 0 0 0 0 0 2 0 0.691 0.871 1.000 248 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 FOS(1), MAP2K3(1), MAP2K6(1), MAP3K1(2), MAPK8(1), NFKBIA(1), TLR10(1), TLR2(1), TLR3(1), TLR6(2), TLR7(2), TLR9(2), TOLLIP(1) 15759099 17 17 17 4 7 4 0 3 3 0 0.272 0.873 1.000 249 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1B(1), ADRB2(1), CHRM1(1), CHRM3(3), CHRM5(1), DRD5(3), HRH1(1), HTR1B(2), HTR1E(1), HTR2A(1), HTR2B(2), HTR4(1), HTR5A(1) 11095685 19 18 19 5 8 3 0 3 5 0 0.261 0.874 1.000 250 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 17 EGF(3), MAPK1(1), PTPRB(2), RAF1(1), RASA1(2), SHC1(1), SPRY2(1), SPRY4(1) 9603030 12 10 12 3 1 3 0 3 5 0 0.423 0.877 1.000 251 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 GRIN1(1), JAK2(1), NFKBIA(1) 5465414 3 3 3 1 0 0 0 0 3 0 0.749 0.880 1.000 252 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(2), ENPP1(1), ENPP3(2), NADSYN1(1), NNMT(1), NT5C(2), NT5E(1) 9271810 10 10 10 3 1 6 1 1 1 0 0.437 0.881 1.000 253 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 CHRM1(1), CHRNA1(2), FLT4(1), KDR(4), NOS3(3), PDE2A(1), PDE3A(1), PRKACG(1), PRKAR1A(2), PRKG2(1), RYR2(10), TNNI1(1) 17456491 28 27 28 7 8 7 1 7 5 0 0.190 0.882 1.000 254 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(3), CACNA1A(2), CACNA1B(4), GNAS(3), GRM4(3), ITPR3(4), KCNB1(3), PDE1A(1), PLCB2(3), PRKACG(1), SCNN1B(1), TAS1R2(2), TAS1R3(1), TAS2R1(2), TAS2R16(2), TAS2R4(2), TAS2R40(2), TAS2R41(1), TAS2R9(1), TRPM5(1) 24573015 42 39 42 9 17 7 1 10 7 0 0.123 0.882 1.000 255 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(4), LPL(1), NCOA1(1), NCOA2(1), PPARG(1), RXRA(1) 7953781 9 9 9 3 1 4 0 3 1 0 0.628 0.883 1.000 256 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(3), ABCB4(3), ABCC3(1) 6171322 7 7 7 3 1 1 1 2 2 0 0.825 0.885 1.000 257 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 28 CABIN1(2), HDAC5(1), IGF1R(2), MAP2K6(1), MAPK7(3), NFATC1(1), NFATC2(2), YWHAH(1) 13395083 13 12 13 2 2 3 1 2 5 0 0.198 0.886 1.000 258 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS2(1), CPO(1) 3415162 2 2 2 2 0 1 0 0 1 0 0.881 0.891 1.000 259 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), PTPRU(1), REG1A(1), TYK2(2) 5388859 6 6 6 3 1 1 0 1 3 0 0.862 0.893 1.000 260 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(1), FOS(1), THBS1(1) 3184347 3 3 3 2 0 2 0 0 1 0 0.800 0.894 1.000 261 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AP2M1(1), BIN1(1), SYNJ1(1), SYNJ2(3) 9282683 6 6 6 1 2 2 0 1 1 0 0.409 0.895 1.000 262 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT2(1), ECHS1(1), HADHA(2) 3360048 4 4 4 4 0 1 0 2 1 0 0.952 0.896 1.000 263 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(4), PML(1), RB1(3), SP100(2), TNF(1) 7841643 11 11 11 4 3 2 0 2 4 0 0.729 0.897 1.000 264 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(6), C6(1), C7(2), C8A(2) 5386542 11 11 11 6 5 2 0 1 3 0 0.791 0.898 1.000 265 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(2), TYK2(2) 4669623 4 4 4 3 1 0 0 1 2 0 0.952 0.899 1.000 266 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 FOS(1), POLR2A(1), PRKACG(1), PRKAR1A(2) 5563314 5 5 5 2 2 1 0 1 1 0 0.781 0.900 1.000 267 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IL1R1(1), IL6(1), IRAK3(1), MAP2K3(1), MAP2K6(1), MAP3K1(2), MAPK8(1), NFKBIA(1), TNF(1), TOLLIP(1) 12794546 11 11 11 2 3 5 0 1 2 0 0.194 0.900 1.000 268 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 CHST11(1), CHST13(1), SULT2B1(2) 3959948 4 3 4 2 1 0 0 2 1 0 0.865 0.900 1.000 269 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(1), FOS(1), GNAI1(3), GNAS(3), NFATC1(1), NFATC2(2), NFATC4(1), PLCG1(4), PRKACG(1), PRKAR1A(2), PRKCA(1), RAF1(1), RPS6KA3(1) 15077643 22 22 21 5 6 5 0 5 6 0 0.320 0.902 1.000 270 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 31 DOCK1(1), FOS(1), HGF(2), MAPK1(1), MAPK8(1), MET(4), PAK1(1), PTK2B(1), RAF1(1), RASA1(2), STAT3(1) 16509278 16 15 16 3 2 6 0 2 6 0 0.201 0.903 1.000 271 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ARPC1B(1) 3494857 1 1 1 1 0 1 0 0 0 0 0.899 0.904 1.000 272 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BRAF(3), CREB3(3), MAPK1(1), MKNK1(1), RPS6KA1(1), RPS6KA3(1), SHC1(1), SOS2(1) 12728816 12 12 12 3 0 3 0 6 3 0 0.658 0.906 1.000 273 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CHIA(1), GFPT1(1), GFPT2(2), GNPDA1(1), HEXA(1), HK1(3), HK3(1), MTMR6(1), PGM3(1), RENBP(3) 12384265 15 15 15 4 2 6 0 4 3 0 0.432 0.906 1.000 274 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(1), ACAT2(1), ECHS1(1), HADHA(2) 3600996 5 5 5 3 0 2 0 2 1 0 0.833 0.907 1.000 275 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 HEXA(1), ST3GAL1(1) 4634004 2 2 2 1 0 0 1 0 1 0 0.919 0.907 1.000 276 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(1), ABP1(3), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), CNDP1(1), DPYS(2), ECHS1(1), GAD2(1), HADHA(2) 11632891 18 17 18 5 9 2 0 2 5 0 0.308 0.908 1.000 277 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 FDPS(1), IDI1(1), MVD(1), NSDHL(2) 8309818 5 5 5 1 2 1 0 1 1 0 0.555 0.908 1.000 278 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(2), CD44(2), TNF(1), TNFSF8(1) 5664869 6 6 6 3 2 3 0 0 1 0 0.711 0.909 1.000 279 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ECHS1(1), HADHA(2) 5245847 10 10 10 5 4 2 0 1 3 0 0.689 0.912 1.000 280 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATR(1), BRCA2(2), CHEK2(1), FANCC(1), FANCD2(2), FANCE(2), RAD17(1), RAD50(1), RAD9A(1), TREX1(1) 18617278 13 13 13 2 2 5 0 3 3 0 0.288 0.913 1.000 281 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 GFPT1(1), GNPDA1(1), HEXA(1), HK1(3), HK3(1), PGM3(1), RENBP(3) 7320472 11 11 11 4 1 5 0 3 2 0 0.613 0.913 1.000 282 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 PRMT5(2), PRMT8(1) 6064239 3 3 3 0 0 2 1 0 0 0 0.317 0.913 1.000 283 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 DNMT1(1), DNMT3A(4), DNMT3B(1), MARS2(1) 7506034 7 7 7 2 2 2 0 2 1 0 0.471 0.914 1.000 284 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(1), ADCY3(1), ADCY9(2), ATP6V0A2(1), ATP6V1C2(1), ATP6V1D(1), ERO1L(1), GNAS(3), PLCG1(4), PLCG2(4), PRKCA(1) 15919630 20 19 19 4 10 5 0 2 3 0 0.181 0.915 1.000 285 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(1), EXT2(1), EXTL1(2), HS3ST3A1(1), HS6ST2(2), NDST2(1), NDST3(2) 8957134 10 10 10 3 4 1 1 3 1 0 0.499 0.917 1.000 286 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 APC(1), DAG1(1), DLG4(1), GNAI1(3), ITPR1(2), ITPR2(4), ITPR3(4), MAPK1(1), PITX2(1), PTX3(1), RYR1(7) 19746251 26 24 26 5 4 8 2 8 4 0 0.138 0.920 1.000 287 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 GGT1(2), MARS2(1), PRMT5(2), PRMT8(1), SCLY(1) 10751059 7 7 7 1 1 4 2 0 0 0 0.206 0.921 1.000 288 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 MAP3K1(2), NFATC1(1), NFATC2(2), NFKBIA(1), PLCG1(4), PRKACG(1), PRKAR1A(2) 12065408 13 12 12 3 3 4 0 2 4 0 0.350 0.929 1.000 289 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(4), MAP2K3(1), MAP2K6(1), NFKBIA(1), NR3C1(1), TGFBR1(1), TGFBR2(1), TLR2(1), TNF(1) 12817917 12 12 12 3 3 4 0 2 3 0 0.386 0.930 1.000 290 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 CISH(1), IL13RA1(1), IL4R(1), JAK2(1), JAK3(1), PI3(1), SHC1(1), SOS2(1), STAT6(2), TYK2(2) 14984405 12 12 12 2 3 0 1 5 3 0 0.325 0.930 1.000 291 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6(1), JAK2(1), JAK3(1), PIAS3(1), PTPRU(1), REG1A(1), STAT3(1) 6582758 8 8 8 3 2 1 0 3 2 0 0.671 0.931 1.000 292 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATR(1), CHEK2(1), YWHAH(1) 6520951 3 3 3 0 1 1 0 0 1 0 0.528 0.931 1.000 293 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 39 BRAF(3), CREB3(3), CREBBP(4), DAG1(1), MAP1B(2), MAPK1(1), MAPK8(1), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), RPS6KA3(1), SHC1(1), TH(1) 20069271 21 21 21 4 2 7 0 7 5 0 0.298 0.932 1.000 294 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(1), FTCD(3), GART(1), MTHFR(1) 8151769 6 6 6 2 3 0 0 1 2 0 0.635 0.933 1.000 295 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 40 FOS(1), LAT(1), MAP3K1(2), MAPK8(1), NFATC1(1), NFATC2(2), NFATC4(1), NFKBIA(1), PLCG1(4), PRKCA(1), RAF1(1), RASA1(2), SHC1(1), VAV1(3), ZAP70(2) 18998388 24 23 23 5 7 8 0 4 5 0 0.127 0.934 1.000 296 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(4), NCOA3(1), PRKACG(1), PRKAR1A(2), RXRA(1) 8917003 9 9 9 3 2 2 0 2 3 0 0.748 0.934 1.000 297 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSD(1), ARSE(1), GALC(1), LCT(2), NEU1(1), NEU2(2), SMPD2(1) 10453589 9 9 9 2 5 0 0 3 1 0 0.458 0.939 1.000 298 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 13 IGF1R(2), IRS1(2), MAPK1(1), RAF1(1), SHC1(1), YWHAH(1) 6545186 8 8 8 3 1 3 0 1 3 0 0.614 0.940 1.000 299 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 ETS1(1), ETV3(1), FOS(1), HDAC2(3), HDAC5(1), NCOR2(3), SIN3A(2) 11250231 12 11 12 3 2 1 1 1 7 0 0.716 0.942 1.000 300 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 BAX(1), CYCS(1) 5773392 2 2 2 0 0 0 0 1 1 0 0.589 0.942 1.000 301 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(1), DHRSX(1), ESCO2(1) 7119953 3 3 3 0 1 1 0 0 1 0 0.462 0.943 1.000 302 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 ICAM1(1), ITGAL(2), ITGB2(1), PRF1(1) 3774024 5 4 5 4 4 0 0 0 1 0 0.858 0.944 1.000 303 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDHPPT(1) 2997755 1 1 1 0 0 0 0 0 1 0 0.705 0.944 1.000 304 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 35 FOS(1), MAP3K1(2), MAPK1(1), MAPK8(1), NFATC1(1), NFATC2(2), NFATC4(1), PLA2G4A(4), PLCG1(4), RAF1(1), SHC1(1), VAV1(3) 16936022 22 20 21 5 5 9 0 5 3 0 0.186 0.944 1.000 305 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKBIA(1), PLCB1(2), PRKCA(1) 3553840 4 4 4 3 1 0 0 2 1 0 0.905 0.948 1.000 306 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 48 CALR(1), CREBBP(4), F2(3), GATA4(1), MAPK1(1), MAPK8(1), NFATC1(1), NFATC2(2), NFATC4(1), PRKACG(1), PRKAR1A(2), RAF1(1) 18542047 19 19 19 4 5 4 0 5 5 0 0.218 0.949 1.000 307 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK2(1), JAK3(1), MAPK1(1), STAT3(1), TYK2(2) 5083239 6 6 6 3 2 1 0 1 2 0 0.817 0.950 1.000 308 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 MAF(1), MAP2K3(1), NFATC1(1), NFATC2(2), PRKACG(1), PRKAR1A(2) 5267777 8 8 8 4 3 0 0 3 2 0 0.780 0.950 1.000 309 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), HLA-DRA(1), IFNGR2(1), IL12B(1), IL12RB1(1), IL18(2), IL4R(1) 5454629 8 8 8 5 2 0 1 3 2 0 0.905 0.950 1.000 310 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), JAK2(1), PTPRU(1), REG1A(1) 4913825 4 4 4 3 1 1 0 0 2 0 0.877 0.950 1.000 311 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 ECHS1(1), HADHA(2), HSD17B4(2) 5103202 5 5 5 3 0 1 0 2 2 0 0.904 0.951 1.000 312 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 7 ACO1(1) 3128015 1 1 1 0 0 1 0 0 0 0 0.679 0.951 1.000 313 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 20 BCR(1), FOS(1), JAK2(1), MAP3K1(2), MAPK8(1), RAF1(1), STAT5B(1) 10480010 8 8 8 2 1 4 0 1 2 0 0.376 0.952 1.000 314 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 ABAT(1), ACADS(2), ACAT2(1), ACSM1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), ECHS1(1), GAD2(1), HADHA(2), HSD17B4(2), HSD3B7(1), ILVBL(1), L2HGDH(1), PDHA1(3), PDHA2(2), PDHB(1) 17482181 27 26 27 7 8 4 0 7 8 0 0.222 0.952 1.000 315 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CLOCK(1), PER1(2) 3683670 3 3 3 3 0 1 0 1 1 0 0.971 0.952 1.000 316 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(1), CDH1(1), CREBBP(4), TGFBR1(1), TGFBR2(1) 11063197 8 8 8 2 3 2 0 2 1 0 0.520 0.953 1.000 317 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(2), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH3B2(1), ALDH7A1(1), FBP2(1), G6PC(3), G6PC2(1), HK1(3), HK3(1), LDHA(1), LDHAL6B(1), LDHB(1), PDHA1(3), PDHA2(2), PDHB(1), PFKL(1), PGAM2(1), PGK1(1), PGM3(1), PKLR(1) 25089207 38 36 38 9 13 10 1 9 5 0 0.0740 0.954 1.000 318 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 FBP2(1), G6PD(2), PFKL(1), PGM3(1), PRPS1(1), PRPS1L1(1), PRPS2(1), TALDO1(1), TKTL2(1) 10480608 10 10 10 3 6 2 0 2 0 0 0.372 0.958 1.000 319 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(1), ICAM1(1), ITGAL(2), ITGB2(1), PTPRC(3) 4634569 8 7 8 4 5 1 0 1 1 0 0.667 0.958 1.000 320 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(1), ICAM1(1), ITGAL(2), ITGB2(1), PTPRC(3) 4860225 8 7 8 4 5 1 0 1 1 0 0.676 0.962 1.000 321 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(1), ACACA(4), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH6A1(1), ECHS1(1), HADHA(2), LDHA(1), LDHB(1) 14264471 19 18 19 5 7 5 0 4 3 0 0.311 0.962 1.000 322 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 ANKRD6(1), APC(1), CTNNB1(1), DKK2(2), LRP1(5), NKD2(1), SENP2(1), WIF1(2) 17407482 14 14 14 2 4 2 0 5 3 0 0.224 0.963 1.000 323 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 50 AKR1C3(2), ALOX12B(1), CYP2B6(1), CYP2C8(1), CYP4A11(1), CYP4A22(1), CYP4F3(4), EPHX2(2), GGT1(2), GPX2(1), LTA4H(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PTGES2(1), PTGS1(1), PTGS2(1) 16367341 27 27 27 7 9 5 0 9 4 0 0.249 0.965 1.000 324 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 SREBF1(3) 5204811 3 2 3 0 0 2 0 1 0 0 0.351 0.966 1.000 325 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 F13B(1), HSD17B4(2), HSD3B2(1) 3487550 4 4 4 3 1 0 0 2 1 0 0.944 0.967 1.000 326 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 19 H2AFX(1), RAF1(1), RALA(1), RALGDS(2) 6607228 5 5 5 2 1 1 0 0 3 0 0.746 0.967 1.000 327 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), IFNAR1(2), MAPK8(1) 4779366 4 4 4 3 0 2 0 1 1 0 0.898 0.969 1.000 328 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 45 FN3K(1), INPP4B(1), INPPL1(1), ISYNA1(1), OCRL(2), PI4KA(2), PI4KB(2), PIK3CG(2), PIP4K2B(1), PIP4K2C(2), PLCB1(2), PLCB2(3), PLCB4(1), PLCD3(2), PLCE1(3), PLCG1(4), PLCG2(4), PLCZ1(1), PTPMT1(1), SYNJ1(1), SYNJ2(3) 30767722 40 39 39 8 10 12 1 8 9 0 0.148 0.971 1.000 329 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX3(1), FADS2(1), FASN(1), HADHA(2), PECR(1) 6238209 6 6 6 4 0 2 0 2 2 0 0.895 0.971 1.000 330 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 GREB1(2) 4723804 2 2 2 0 2 0 0 0 0 0 0.416 0.972 1.000 331 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(3), AMY2B(1), ENPP1(1), ENPP3(2), G6PC(3), GANAB(2), HK1(3), HK3(1), MGAM(3), PGM3(1), PYGB(1), PYGL(1), SI(4), UGT1A1(3), UGT2B4(1), UXS1(2) 24520261 32 30 32 6 10 11 0 7 4 0 0.0668 0.972 1.000 332 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 FBP2(1), G6PD(2), PGM3(1), PRPS1(1), PRPS1L1(1), PRPS2(1), TALDO1(1) 8812474 8 8 8 3 5 2 0 1 0 0 0.490 0.972 1.000 333 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ASPH(2), LDHA(1), NOS3(3) 7331427 6 5 6 2 3 1 0 2 0 0 0.599 0.972 1.000 334 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 ABAT(1), ADSL(1), AGXT2(1), ASL(1), ASNS(1), CAD(2), CRAT(1), GAD2(1), PC(1) 11236344 10 9 10 2 5 2 0 1 2 0 0.359 0.972 1.000 335 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 MAPK1(1), RAF1(1) 3552238 2 2 2 2 0 1 0 0 1 0 0.864 0.972 1.000 336 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH3B2(1), FBP2(1), G6PC(3), HK1(3), HK3(1), LDHA(1), LDHB(1), PDHA1(3), PDHA2(2), PDHB(1), PGK1(1), PGM3(1), PKLR(1) 21059834 32 31 32 8 9 11 1 6 5 0 0.108 0.973 1.000 337 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH3B2(1), FBP2(1), G6PC(3), HK1(3), HK3(1), LDHA(1), LDHB(1), PDHA1(3), PDHA2(2), PDHB(1), PGK1(1), PGM3(1), PKLR(1) 21059834 32 31 32 8 9 11 1 6 5 0 0.108 0.973 1.000 338 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(2), APOA1(1), APOA4(1), LIPC(1), LPL(1), LRP1(5), SCARB1(1), SOAT1(1) 11796740 13 13 13 4 4 3 0 5 1 0 0.545 0.973 1.000 339 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(1), B3GNT3(1), B3GNT4(1), B3GNT5(2), FUT5(1), ST3GAL6(1) 6989115 7 7 7 3 0 3 0 2 2 0 0.725 0.974 1.000 340 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(1), CREBBP(4), CSNK2A1(1), CTNNB1(1), WIF1(2) 12657940 9 9 9 2 1 3 0 2 3 0 0.479 0.975 1.000 341 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT7(1), CHST1(1), FUT8(1), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1) 5385912 6 6 6 3 3 2 1 0 0 0 0.702 0.975 1.000 342 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 ETV5(1), IL12B(1), IL12RB1(1), IL18(2), JAK2(1), MAP2K6(1), MAPK8(1), TYK2(2) 8053825 10 10 10 6 2 2 1 2 3 0 0.909 0.976 1.000 343 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSD(1), ARSE(1), DEGS1(1), GALC(1), LCT(2), NEU1(1), NEU2(2), SMPD2(1), SMPD3(1), SMPD4(1) 15432647 12 12 12 2 5 2 0 3 2 0 0.280 0.976 1.000 344 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 YWHAH(1) 3328052 1 1 1 0 0 0 0 0 1 0 1.000 0.976 1.000 345 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 IL12B(1), IL12RB1(1), JAK2(1), TYK2(2) 6351991 5 5 5 4 1 0 1 1 2 0 0.949 0.977 1.000 346 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 GGT1(2), LTA4H(1), PTGS1(1), PTGS2(1) 6507513 5 5 5 2 2 1 0 1 1 0 0.674 0.977 1.000 347 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), AGK(1), AGPAT2(1), AGPAT3(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), DGKA(1), DGKD(2), DGKH(1), DGKQ(1), GK(1), GK2(3), GPAM(1), LCT(2), LIPC(1), LIPG(1), LPL(1), PNLIPRP1(2) 25285723 32 26 32 6 14 8 1 5 4 0 0.0355 0.977 1.000 348 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(1), GART(1), MTHFR(1) 7692807 3 3 3 1 1 0 0 1 1 0 0.671 0.979 1.000 349 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 19 EIF4A1(2), EIF4A2(1), EIF4G1(3), EIF4G3(3), GHR(1), IRS1(2), MAPK1(1), MKNK1(1), PABPC1(2), PRKCA(1) 10147230 17 15 17 5 5 6 0 2 4 0 0.554 0.979 1.000 350 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 RPL10L(1), RPL37A(1), RPL7(1), RPS2(1), RPS24(1) 9704954 5 5 5 1 2 0 0 2 1 0 0.724 0.980 1.000 351 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C3(6), C6(1), C7(2), C8A(2), MBL2(2) 9142828 13 13 13 6 5 3 0 1 4 0 0.719 0.980 1.000 352 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C3(6), C6(1), C7(2), C8A(2) 7513172 11 11 11 6 5 2 0 1 3 0 0.793 0.980 1.000 353 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(1), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), SOAT2(1), SRD5A1(1) 10006782 15 15 15 5 6 3 0 3 3 0 0.428 0.980 1.000 354 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V1C2(1), ATP6V1D(1) 6479542 2 2 2 0 1 1 0 0 0 0 0.457 0.980 1.000 355 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V1C2(1), ATP6V1D(1) 6479542 2 2 2 0 1 1 0 0 0 0 0.457 0.980 1.000 356 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V1C2(1), ATP6V1D(1) 6479542 2 2 2 0 1 1 0 0 0 0 0.457 0.980 1.000 357 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK2(1), JAK3(1), PIAS3(1), PTPRU(1), REG1A(1), SOAT1(1) 5912503 7 7 7 5 1 1 0 3 2 0 0.942 0.980 1.000 358 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ASL(1), CPS1(2), GLUD1(2) 7581686 5 4 5 3 0 0 0 2 3 0 0.967 0.981 1.000 359 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 F13A1(2), F2(3), FGA(1), FGB(1), FGG(1) 5768302 8 8 8 4 3 2 0 2 1 0 0.730 0.982 1.000 360 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(1), CREBBP(4), CTNNB1(1), LDB1(1), PITX2(1), TRRAP(4) 14301196 12 12 12 3 5 2 0 3 2 0 0.438 0.984 1.000 361 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 AGPAT2(1), AGPAT3(1), CHAT(1), DGKA(1), DGKD(2), DGKH(1), DGKQ(1), ESCO2(1), GNPAT(1), GPAM(1), LYPLA1(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PLD1(3) 28246196 22 20 22 2 8 6 1 3 4 0 0.0289 0.985 1.000 362 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 PRF1(1), SREBF1(3) 7906605 4 3 4 1 1 2 0 1 0 0 0.603 0.985 1.000 363 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ARPC1B(1), NCK1(1), NCKAP1(2), WASF3(2) 6568726 6 5 6 3 2 2 0 1 1 0 0.722 0.985 1.000 364 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 11 MUSK(3), PTK2B(1), TERT(1), YWHAH(1) 5438412 6 5 6 4 1 2 0 1 2 0 0.926 0.986 1.000 365 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 28 G6PD(2), GGT1(2), GPX2(1), GSS(1) 7086690 6 6 6 3 3 2 0 1 0 0 0.715 0.986 1.000 366 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V1C2(1), ATP6V1D(1) 6897071 2 2 2 0 1 1 0 0 0 0 0.458 0.987 1.000 367 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), AGPAT2(1), AGPAT3(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), DGKA(1), DGKD(2), DGKH(1), DGKQ(1), GK(1), LCT(2), LIPC(1), LIPG(1), LPL(1), PNLIPRP1(2) 20776832 27 23 27 6 12 6 1 4 4 0 0.0907 0.988 1.000 368 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 28 GNAS(3), IGF1R(2), MAPK1(1), MKNK1(1), PDGFRA(7), PTPRR(2), RAF1(1), RPS6KA1(1), SHC1(1), STAT3(1) 13138576 20 19 20 6 2 7 0 4 7 0 0.572 0.989 1.000 369 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT2(1), ACOT11(1), DHRS2(1), DHRSX(1), ECHS1(1), ESCO2(1), FN3K(1), HADHA(2) 11166274 9 8 9 3 2 2 0 2 3 0 0.672 0.989 1.000 370 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 63 ADAM10(1), ATP6V0A2(1), ATP6V1C2(1), ATP6V1D(1), HBEGF(1), JAM2(1), MAPK12(1), MAPK8(1), MAPK9(1), MET(4), NFKBIA(1), PAK1(1), PLCG1(4), PLCG2(4), PTPRZ1(4), TCIRG1(1), TJP1(3) 28638365 31 29 30 5 7 11 0 3 10 0 0.0623 0.989 1.000 371 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 30 ACPP(3), ALPP(4), ALPPL2(2), CYP1A2(2), CYP2B6(1), CYP2C8(1), CYP3A4(2), CYP3A7(1), CYP4F8(1), PON1(2) 12168144 19 18 19 6 9 2 0 3 5 0 0.542 0.989 1.000 372 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 FBP2(1), PGK1(1), PKLR(1) 7793275 3 3 3 1 2 1 0 0 0 0 0.599 0.990 1.000 373 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMC3(1) 5546589 1 1 1 0 0 1 0 0 0 0 0.677 0.990 1.000 374 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(1), CYCS(1), MAP3K1(2), MAPK1(1), MAPK8(1), RAF1(1), RIPK1(1), TRADD(1) 8865443 9 9 9 4 2 3 0 1 3 0 0.683 0.990 1.000 375 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 31 BCR(1), CDKN2A(1), FLOT1(1), FLOT2(2), ITPR1(2), ITPR2(4), ITPR3(4), PDK1(2), PITX2(1), PLCG2(4), PREX1(2), PTPRC(3), RPS6KA1(1), RPS6KA3(1), SAG(1), TEC(1), VAV1(3) 22522003 34 30 34 9 12 7 1 14 0 0 0.296 0.990 1.000 376 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 CHEK2(1), MAPK8(1), MDM2(2), NFKBIA(1), RAD50(1), RBBP8(1) 12471252 7 7 7 2 0 5 0 1 1 0 0.502 0.990 1.000 377 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 30 MAPK1(1), MAPK12(1), MAPK8(1), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), MAPKAPK5(2), NFKBIA(1) 12916679 9 9 9 2 1 3 0 3 2 0 0.411 0.991 1.000 378 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BNIP1(1), STX11(1), TSNARE1(1), USE1(1), VAMP5(2) 7208649 6 6 5 3 3 1 0 0 2 0 0.706 0.991 1.000 379 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(6), C6(1), C7(2), ICAM1(1), IL6(1), ITGA4(1), ITGAL(2), ITGB2(1), SELP(1), SELPLG(1), TNF(1) 10658859 18 18 18 8 7 5 0 2 4 0 0.522 0.991 1.000 380 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 FOS(1), MAPK1(1), NFKBIA(1), PLCB1(2), PRKCA(1), RAF1(1), TNF(1) 6692104 8 8 8 4 1 3 0 2 2 0 0.692 0.991 1.000 381 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 71 GAB2(1), KRAS(1), LAT(1), MAP2K3(1), MAP2K6(1), MAPK1(1), MAPK12(1), MAPK8(1), MAPK9(1), NRAS(1), PDK1(2), PIK3CG(2), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PLCG1(4), PLCG2(4), PRKCA(1), RAC2(1), RAF1(1), SOS2(1), TNF(1), VAV1(3) 28741042 38 35 37 9 11 13 1 9 4 0 0.123 0.992 1.000 382 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), TGFBR1(1), TGFBR2(1) 4546608 3 3 3 2 2 1 0 0 0 0 0.809 0.992 1.000 383 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 CP(1), EPRS(1), HCCS(2), PPOX(1), UGT1A1(3), UGT2B4(1) 11797588 9 9 9 3 0 4 0 5 0 0 0.666 0.992 1.000 384 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(4), NFKBIA(1), RIPK1(1), TNF(1), TRADD(1) 9661334 8 8 8 3 2 2 0 1 3 0 0.708 0.993 1.000 385 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 BAX(1), CYCS(1), PRKCA(1), TLN1(3) 11437186 6 6 6 2 2 0 0 3 1 0 0.672 0.993 1.000 386 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C3(6), C6(1), C7(2), C8A(2), C8B(1) 8931559 12 12 12 7 5 3 0 1 3 0 0.820 0.993 1.000 387 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 MAP3K1(2), NFKBIA(1), TNFAIP3(1) 7828857 4 4 4 2 2 1 0 0 1 0 0.719 0.994 1.000 388 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(1), ACAA2(1), ACADS(2), ACAT2(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH6A1(1), ALDH7A1(1), AOX1(2), DBT(1), ECHS1(1), HADHA(2), HSD17B4(2), MCCC1(1), MCCC2(2) 18519097 24 21 23 6 9 5 0 4 6 0 0.258 0.994 1.000 389 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 DAG1(1), ITPR1(2), ITPR2(4), ITPR3(4), NFAT5(2), PDE6B(3), PDE6C(3) 15443890 19 18 19 6 5 7 1 4 2 0 0.391 0.994 1.000 390 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 13 IGF1R(2), POLR2A(1), PRKCA(1), RB1(3), TEP1(2), TERT(1) 10663331 10 10 10 4 5 1 0 0 4 0 0.642 0.994 1.000 391 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 13 CDKN1B(1), MAPK1(1), SHC1(1) 6350293 3 3 3 2 0 1 0 1 1 0 0.888 0.994 1.000 392 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 20 ADCY1(1), GNAI1(3), MAPK1(1), PDGFA(1), PDGFRA(7), PLCB1(2), PRKCA(1), SMPD2(1) 10196942 17 15 17 6 4 5 0 4 4 0 0.677 0.995 1.000 393 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 42 BRAF(3), EIF4B(1), MAPK1(1), PGF(1), PIK3CG(2), PIK3R5(1), PRKAA1(1), RPS6KA1(1), RPS6KA3(1), RPS6KA6(1), TSC1(1), TSC2(2), ULK2(1), VEGFB(2), VEGFC(2) 21333206 21 20 20 5 3 5 3 9 1 0 0.319 0.995 1.000 394 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 GLI3(1), PRKACG(1), PRKAR1A(2), SHH(1), SUFU(1) 7202261 6 6 6 4 1 2 0 1 2 0 0.919 0.995 1.000 395 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(4), MAPK1(1) 6384633 5 5 5 3 1 2 0 1 1 0 0.898 0.995 1.000 396 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 UGT1A1(3), UGT2B4(1) 7577691 4 4 4 2 0 1 0 3 0 0 0.842 0.996 1.000 397 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL22RA1(1), JAK2(1), JAK3(1), STAT3(1), STAT5B(1), TYK2(2) 7950800 7 7 7 5 2 0 0 3 2 0 0.961 0.996 1.000 398 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(1) 5504515 1 1 1 0 0 1 0 0 0 0 0.673 0.996 1.000 399 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGTR2(1), F2(3), GNAI1(3), JAK2(1), MAPK1(1), MAPK8(1), MYLK(1), PLCG1(4), PRKCA(1), PTK2B(1), RAF1(1), SHC1(1), STAT3(1) 17953288 20 19 19 5 4 8 0 3 5 0 0.241 0.996 1.000 400 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 MAP3K1(2), NFKBIA(1), RIPK1(1), TANK(2), TNFAIP3(1) 9689912 7 7 7 3 3 2 0 0 2 0 0.667 0.996 1.000 401 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 DLG4(1), GRIN1(1), GRIN2A(3), GRIN2B(3), GRIN2C(2), GRIN2D(2), NOS1(1), PRKACG(1), PRKAR1A(2), PRKCA(1) 11039485 17 16 17 9 5 2 0 6 4 0 0.902 0.996 1.000 402 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(1), ABP1(3), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), CNDP1(1), DPYS(2), ECHS1(1), GAD2(1), HADHA(2) 12519589 18 17 18 7 8 3 0 2 5 0 0.546 0.996 1.000 403 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 23 GH1(1), GHR(1), IRS1(2), JAK2(1), MAPK1(1), PLCG1(4), PRKCA(1), RAF1(1), RPS6KA1(1), SHC1(1), SRF(1), STAT5B(1) 12627301 16 16 15 5 2 6 0 4 4 0 0.526 0.996 1.000 404 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(2), HDAC2(3), NFATC1(1), NFATC2(2), PRKCA(1) 10507499 9 9 9 7 2 1 1 1 4 0 0.985 0.996 1.000 405 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(1), ALDH4A1(1), CAD(2), CPS1(2), EPRS(1), GAD2(1), GFPT1(1), GLUD1(2), GSS(1), NADSYN1(1) 14288654 13 13 13 4 3 4 0 3 3 0 0.621 0.996 1.000 406 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 BRAF(3), CACNA1A(2), GNAI1(3), GNAO1(3), GNAS(3), GRIA1(5), GRIA3(4), GRID2(1), GRM5(1), GUCY1A3(1), GUCY2C(2), GUCY2F(2), IGF1R(2), ITPR1(2), ITPR2(4), ITPR3(4), KRAS(1), MAPK1(1), NOS1(1), NOS3(3), NRAS(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PLCB1(2), PLCB2(3), PLCB4(1), PPP2R2C(1), PRKCA(1), PRKCG(1), PRKG2(1), RAF1(1), RYR1(7) 47597813 74 61 74 14 18 22 3 18 13 0 0.0113 0.996 1.000 407 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(1), FUCA1(1), FUCA2(2), HEXA(1), LCT(2), MAN2B1(1), MAN2B2(1), MAN2C1(1), NEU1(1), NEU2(2) 8803573 13 13 13 6 4 2 1 3 3 0 0.787 0.997 1.000 408 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 IL4R(1), IRS1(2), JAK3(1), SHC1(1), STAT6(2) 6395596 7 7 7 4 2 1 0 3 1 0 0.830 0.997 1.000 409 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR7(1), CD28(1), CXCR4(1), IFNGR2(1), IL12B(1), IL12RB1(1), IL4R(1) 8618564 7 7 7 7 1 1 2 1 2 0 0.980 0.997 1.000 410 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 14 SHC1(1) 6039555 1 1 1 1 0 0 0 1 0 0 0.946 0.997 1.000 411 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 BMPR1B(1), CDKN1B(1), DMC1(1), ESR2(2), FSHR(1), MLH1(2), MSH5(1), NCOR1(3), ZP2(1) 15109417 13 13 13 4 2 4 0 3 4 0 0.692 0.997 1.000 412 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(1) 5765659 1 1 1 0 0 1 0 0 0 0 0.673 0.997 1.000 413 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 23 ATF2(1), BCR(1), FOS(1), MAP3K1(2), MAPK1(1), MAPK8IP3(1), PAPPA(2), RPS6KA1(1), RPS6KA3(1), SHC1(1), VAV1(3) 13088827 15 15 15 5 3 4 0 7 1 0 0.650 0.997 1.000 414 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMC3(1) 6887116 1 1 1 1 0 1 0 0 0 0 0.947 0.997 1.000 415 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(1), ACADS(2), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH6A1(1), AOX1(2), ECHS1(1), HADHA(2), MCCC1(1), MCCC2(2) 15504048 20 19 19 7 7 6 0 3 4 0 0.423 0.997 1.000 416 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(3), ADC(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), ASL(1), ASS1(1), CPS1(2) 12722162 15 15 15 9 8 1 0 1 5 0 0.916 0.998 1.000 417 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN3(1), CTNNA2(1), CTNNB1(1), VCL(1) 8298512 4 4 4 2 1 0 0 2 1 0 0.884 0.998 1.000 418 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 GTF2E1(1), NCOA1(1), NCOA2(1), NCOA3(1), NCOR2(3), POLR2A(1), RXRA(1) 10772473 9 9 9 6 3 3 0 0 3 0 0.919 0.998 1.000 419 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG5(1), FUT8(1), MGAT2(1), MGAT3(2), MGAT5(1) 8605344 6 6 6 3 2 2 0 1 1 0 0.786 0.998 1.000 420 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(1), COL4A4(1), COL4A5(3), COL4A6(3), SLC23A1(1), SLC23A2(1), SLC2A3(1) 10797020 11 11 11 5 5 4 1 1 0 0 0.512 0.998 1.000 421 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 IL12B(1), ITGAX(1), TLR2(1), TLR7(2), TLR9(2) 8005526 7 6 7 4 2 0 1 3 1 0 0.916 0.998 1.000 422 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 PLCB1(2), PRKACG(1), PRKAR1A(2) 6918479 5 5 5 3 1 0 0 3 1 0 0.962 0.998 1.000 423 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(3), ALDH1A3(1), ALDH3A1(3), ALDH3B2(1), DDC(1), LPO(3), MPO(2), TAT(1), TPO(3) 9486911 18 17 18 7 10 3 2 1 2 0 0.486 0.998 1.000 424 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CFL1(1), GNAS(3), LIMK1(3), MAPK1(1), PLCB1(2), PRKCA(1), RAF1(1), ROCK2(1) 10807756 13 13 13 5 2 3 0 5 3 0 0.740 0.998 1.000 425 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(3), GNAI1(3), MAPK1(1), PLA2G4A(4), PLCB1(2), PRKCA(1), PTGS1(1), RAF1(1) 10509208 16 16 16 6 1 5 0 7 3 0 0.660 0.999 1.000 426 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 FBP2(1), PGK1(1), PKLR(1), TKTL2(1) 8709804 4 4 4 2 2 1 0 1 0 0 0.736 0.999 1.000 427 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 11 APC(1), CTNNB1(1) 7483069 2 2 2 3 0 0 0 1 1 0 0.997 0.999 1.000 428 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F13B(1), F2(3), F5(4), F7(1), F8(3), FGA(1), FGB(1), FGG(1), LPA(1), VWF(3) 15204486 19 17 19 7 6 5 1 3 4 0 0.458 0.999 1.000 429 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(1), ACAD8(1), ACAD9(1), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), HSD3B7(1), SOAT1(1), SOAT2(1), SRD5A1(1) 13626237 19 18 19 7 7 2 0 7 3 0 0.593 0.999 1.000 430 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 21 CXCR4(1), GNAI1(3), MAPK1(1), PLCG1(4), PRKCA(1), PTK2B(1), RAF1(1) 10295871 12 12 11 5 1 6 1 1 3 0 0.655 0.999 1.000 431 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 ABP1(3), ESCO2(1) 10903635 4 4 4 2 2 1 0 0 1 0 0.809 0.999 1.000 432 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CLOCK(1), PER1(2), PER2(1) 7356377 4 4 4 3 0 2 0 1 1 0 0.929 0.999 1.000 433 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 FPR1(1), MAP2K3(1), MAP2K6(1), MAP3K1(2), MAPK1(1), NCF2(1), NFATC1(1), NFATC2(2), NFATC4(1), NFKBIA(1), PAK1(1), PLCB1(2), RAF1(1) 16501654 16 15 16 5 5 2 0 3 6 0 0.427 0.999 1.000 434 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 FOS(1), MAP3K1(2), MAPK8(1), NFATC1(1), NFATC2(2), NFATC4(1), PLCG1(4), PRKCA(1), RAF1(1), SHC1(1), VAV1(3) 16478915 18 17 17 6 6 6 0 3 3 0 0.436 0.999 1.000 435 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 CYCS(1), GAS2(1), LMNA(1), NFKBIA(1), RIPK1(1), SPTAN1(2), TRADD(1) 14415675 8 6 8 2 3 1 0 1 3 0 0.467 0.999 1.000 436 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 20 DIAPH1(2), MAPK1(1), MYLK(1), RAF1(1), SHC1(1), TLN1(3) 14440231 9 9 9 3 3 1 0 4 1 0 0.611 0.999 1.000 437 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 HDAC5(1), YWHAH(1) 8738915 2 2 2 1 1 0 0 0 1 0 0.888 0.999 1.000 438 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 32 ATF2(1), MAP3K1(2), MAPK1(1), MAPK8(1), PAK1(1), PRKCA(1), PTK2B(1), RAF1(1), SHC1(1) 13317147 10 10 10 4 2 4 0 1 3 0 0.688 0.999 1.000 439 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 17 ADCY1(1), F2(3), GNAI1(3), PLCB1(2), PRKCA(1), PTK2B(1) 9521223 11 11 11 5 2 3 0 4 2 0 0.772 0.999 1.000 440 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(1), ADRBK2(1), ARRB2(1), CALML3(1), CLCA1(1), CLCA2(1), CNGA3(1), CNGB1(1), GUCA1A(1), PDE1C(1), PRKACG(1), PRKG2(1) 13145628 12 11 12 7 4 1 0 3 4 0 0.867 0.999 1.000 441 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 14 CREBBP(4), IL7R(1), JAK3(1), PTK2B(1), STAT5B(1) 10451259 8 8 8 4 1 2 0 4 1 0 0.854 0.999 1.000 442 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 DNMT1(1), DNMT3A(4), DNMT3B(1), MARS2(1), TAT(1) 8945719 8 8 8 4 2 2 1 2 1 0 0.721 0.999 1.000 443 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 ARHGDIB(1), CASP1(1), CYCS(1), LMNA(1), LMNB2(1), PRF1(1) 8320667 6 5 6 3 2 2 0 2 0 0 0.815 0.999 1.000 444 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(1), AGTR2(1), CMA1(1), COL4A1(1), COL4A4(1), COL4A5(3), COL4A6(3), REN(1) 10866940 12 12 12 6 6 4 0 1 1 0 0.658 0.999 1.000 445 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 ATF2(1), IL1R1(1), MAP2K5(1), MAP3K1(2), MAP3K10(1), MAP3K12(2), MAP3K13(1), MAP3K4(2), MAP3K5(2), MAPK7(3), MAPK8(1), MAPK9(1), PAPPA(2), SHC1(1) 21359989 21 19 21 5 2 8 0 6 5 0 0.407 1.000 1.000 446 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 CES2(1), CYP3A4(2), UGT1A1(3) 9830157 6 6 6 3 1 1 0 3 1 0 0.856 1.000 1.000 447 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 IL1R1(1), MAP3K1(2), NFKBIA(1), RIPK1(1), TNF(1), TNFAIP3(1), TRADD(1) 10528674 8 8 8 5 3 3 0 0 2 0 0.863 1.000 1.000 448 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 30 ANGPTL2(1), DAG1(1), DGKA(1), ITPR1(2), ITPR2(4), ITPR3(4), MAPK1(1), PAK1(1), PDE3A(1), PI3(1), RPS4X(1) 19362765 18 17 18 5 2 8 1 6 1 0 0.423 1.000 1.000 449 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 FBP2(1), GMDS(1), HK1(3), HK3(1) 10334603 6 6 6 3 2 3 0 0 1 0 0.675 1.000 1.000 450 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(1), ATF2(1), BMP4(2), CTNNB1(1), GATA4(1), RFC1(1), TGFBR1(1), TGFBR2(1) 15690578 9 9 9 3 3 2 0 1 3 0 0.720 1.000 1.000 451 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 24 APC(1), CTNNB1(1), GJA1(1), GNAI1(3), LBP(1), TOLLIP(1) 11644811 8 8 8 4 1 1 0 3 3 0 0.922 1.000 1.000 452 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(1), FUCA1(1), FUCA2(2), HEXA(1), HYAL1(1), IDS(1), LCT(2), MAN2B1(1), MAN2B2(1), MAN2C1(1), NAGLU(2), NEU1(1), NEU2(2), SPAM1(1) 14915874 18 18 18 6 5 4 1 4 4 0 0.541 1.000 1.000 453 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(3), ALDH1A3(1), ALDH3A1(3), ALDH3B2(1), DDC(1), ESCO2(1), LPO(3), MPO(2), TAT(1), TPO(3) 14741023 19 18 19 7 10 3 2 1 3 0 0.499 1.000 1.000 454 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ACTB(1), ACTG1(1), ARHGEF2(2), CDH1(1), CTNNB1(1), CTTN(1), HCLS1(1), NCK1(1), NCL(1), PRKCA(1), ROCK2(1), TLR5(1), TUBA3C(2), TUBA3D(1), TUBB3(1), TUBB6(1), TUBB8(1), WAS(2) 22595341 21 21 21 6 8 2 3 3 5 0 0.413 1.000 1.000 455 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ACTB(1), ACTG1(1), ARHGEF2(2), CDH1(1), CTNNB1(1), CTTN(1), HCLS1(1), NCK1(1), NCL(1), PRKCA(1), ROCK2(1), TLR5(1), TUBA3C(2), TUBA3D(1), TUBB3(1), TUBB6(1), TUBB8(1), WAS(2) 22595341 21 21 21 6 8 2 3 3 5 0 0.413 1.000 1.000 456 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ALG6(1), CELSR1(5), CELSR2(1), CELSR3(5), CHRM3(3), EMR2(1), EMR3(1), FSHR(1), GNRHR(1), GPR116(4), GPR132(1), GPR133(1), GPR17(1), GRPR(3), HRH4(1), LPHN2(2), LPHN3(3), OR8G2(2), SSTR2(1), TAAR5(1), TSHR(2) 28768948 41 40 41 11 12 14 2 9 4 0 0.111 1.000 1.000 457 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 ABAT(1), ADSL(1), ADSSL1(1), AGXT2(1), ASL(1), ASNS(1), ASS1(1), CAD(2), CRAT(1), DARS2(1), GAD2(1), PC(1), PDHA1(3), PDHA2(2), PDHB(1) 16316557 19 17 19 5 7 6 0 3 3 0 0.329 1.000 1.000 458 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 UGT1A1(3), UGT2A3(1), UGT2B10(4), UGT2B11(3), UGT2B28(2), UGT2B4(1), UGT2B7(1) 11758667 15 14 15 6 2 3 0 10 0 0 0.762 1.000 1.000 459 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 EGF(3), ETS1(1), FOS(1), HOXA7(1), MAP2K3(1), MAP2K6(1), MAP3K1(2), MAP3K5(2), MAPK1(1), MAPK8(1), NFKBIA(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(1), RAF1(1), RIPK1(1), TNF(1) 20035434 22 22 22 7 6 9 1 2 4 0 0.305 1.000 1.000 460 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 24 ADCY1(1), GNAS(3), MAPK1(1), PRKACG(1), PRKAR1A(2), PRKCA(1), RPS6KA1(1) 10940559 10 10 10 5 4 1 0 3 2 0 0.901 1.000 1.000 461 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 61 CDKN1B(1), CDKN2A(1), CREB3(3), ERBB4(1), INPPL1(1), IRS1(2), IRS4(2), MET(4), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PDK1(2), PREX1(2), RPS6KA1(1), RPS6KA3(1), SHC1(1), SOS2(1), TSC1(1), TSC2(2), YWHAE(1), YWHAH(1) 32040013 32 30 32 7 3 6 0 16 7 0 0.332 1.000 1.000 462 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 94 ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), CACNA1D(1), CACNA1F(3), CACNA1S(5), CALML3(1), GNAS(3), GNRHR(1), HBEGF(1), ITPR1(2), ITPR2(4), ITPR3(4), KRAS(1), MAP2K3(1), MAP2K6(1), MAP3K1(2), MAP3K4(2), MAPK1(1), MAPK12(1), MAPK7(3), MAPK8(1), MAPK9(1), NRAS(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PLCB1(2), PLCB2(3), PLCB4(1), PLD1(3), PRKACG(1), PRKCA(1), PTK2B(1), RAF1(1), SOS2(1) 53834776 71 62 71 13 22 18 2 17 12 0 0.0123 1.000 1.000 463 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(1), POLR2A(1), POLR2B(1), POLR2G(1), POLR3A(3), POLR3B(1), POLR3GL(1), POLR3K(1) 10106462 10 10 10 6 2 4 1 2 1 0 0.875 1.000 1.000 464 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(2), POLD1(1), POLE(1), POLQ(2), PRIM1(1), PRIM2(2), REV1(3), REV3L(1) 17383018 13 11 13 7 5 2 0 2 4 0 0.958 1.000 1.000 465 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), NFKBIA(1), RIPK1(1), TNF(1), TNFAIP3(1), TRADD(1) 11749550 6 6 6 5 2 1 0 1 2 0 0.960 1.000 1.000 466 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 46 BRD4(1), CDKN2A(1), FLOT1(1), FLOT2(2), INPPL1(1), IRS1(2), IRS4(2), MAPK1(1), PDK1(2), PPYR1(1), RAF1(1), RPS6KA1(1), RPS6KA3(1), SHC1(1), SOS2(1), YWHAE(1), YWHAH(1) 23731203 21 20 21 5 3 5 0 10 3 0 0.375 1.000 1.000 467 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 57 BAX(1), CAD(2), CASP8AP2(1), DEDD2(1), FAF1(1), MAP3K1(2), MAP3K5(2), MAPK1(1), MAPK8(1), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), MET(4), NFAT5(2), NFKBIA(1), RIPK1(1), TNFRSF6B(1), TPX2(1) 29821665 25 21 25 5 2 9 0 2 12 0 0.246 1.000 1.000 468 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 EPRS(1), FARS2(2), GARS(1), HARS(1), LARS(1), MARS2(1), RARS(1), WARS2(1) 13780686 9 9 9 4 1 6 0 2 0 0 0.707 1.000 1.000 469 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 G6PC(3), G6PC2(1), GANC(1), HK1(3), HK3(1), HSD3B7(1), LCT(2), MGAM(3), PFKL(1), PGM3(1) 16696536 17 16 17 6 8 5 0 3 1 0 0.388 1.000 1.000 470 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(2), CALCR(1), CD97(1), ELTD1(1), EMR1(1), EMR2(1), GIPR(1), GLP2R(1), GPR64(2), LPHN2(2), LPHN3(3), SCTR(1) 11524661 17 15 17 8 3 6 1 6 1 0 0.796 1.000 1.000 471 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(1), FOS(1), IL2RB(2), JAK3(1), MAPK8(1), RAF1(1), SHC1(1), STAT5B(1) 10086593 9 9 9 5 0 4 0 4 1 0 0.817 1.000 1.000 472 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 PIGB(1), PIGS(1), PIGW(1), PIGZ(1) 10254746 4 4 4 3 1 0 0 2 1 0 0.943 1.000 1.000 473 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(3), CASP1(1), MAGI2(2), RERE(4) 10330481 10 10 10 5 3 2 0 4 1 0 0.880 1.000 1.000 474 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 31 CDKN2A(1), PDK1(2), RPS6KA1(1), RPS6KA3(1), SHC1(1), SOS2(1), TEC(1), YWHAE(1), YWHAH(1) 14207631 10 10 10 4 0 0 0 9 1 0 0.905 1.000 1.000 475 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(1), ADC(1), ALDH4A1(1), CAD(2), CPS1(2), EPRS(1), GAD2(1), GFPT1(1), GFPT2(2), GLUD1(2), GLUD2(1), GSS(1), NADSYN1(1) 17016905 17 16 17 6 3 5 0 5 4 0 0.722 1.000 1.000 476 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 BAX(1), CYCS(1), FASLG(1), MAP3K1(2), MDM2(2), NFKBIA(1), PARP1(2), PRF1(1), RIPK1(1), TNF(1), TRADD(1) 15781366 14 14 14 6 3 4 0 4 3 0 0.765 1.000 1.000 477 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 23 EIF2B4(1), EIF2S2(1), FLT4(1), KDR(4), NOS3(3), PLCG1(4), PRKCA(1), SHC1(1) 13042873 16 15 15 7 6 5 0 3 2 0 0.661 1.000 1.000 478 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(1), ARHGDIB(1), BAG4(1), CRADD(1), CYCS(1), LMNA(1), LMNB2(1), MAP3K1(2), MAP3K5(2), MAPK8(1), MDM2(2), NFKBIA(1), NUMA1(3), PRKDC(3), RASA1(2), RB1(3), RIPK1(1), SPTAN1(2), TNF(1), TRADD(1) 29726062 31 27 31 7 7 9 1 7 7 0 0.197 1.000 1.000 479 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AP2M1(1), EEA1(1), PFKL(1), PLCG1(4) 10751892 7 7 6 4 2 3 0 1 1 0 0.852 1.000 1.000 480 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 CREBBP(4), GTF2E1(1), HDAC2(3), HDAC4(2), HDAC5(1), HDAC6(2), NCOR2(3), POLR2A(1) 19982093 17 17 17 8 7 2 0 2 6 0 0.902 1.000 1.000 481 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 63 CCNA1(2), CCNB1(1), CCNE2(1), CCNG2(1), CDKN1B(1), CDKN2A(1), CDKN2C(1), CREB3(3), MCM6(1), MCM7(1), MDM2(2), MYT1(2), POLE(1), PRIM1(1), RB1(3), RPA1(1), TNXB(4), WEE1(1) 32896034 28 26 28 7 4 6 0 4 14 0 0.506 1.000 1.000 482 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG13(1), ALG14(1), ALG5(1), ALG6(1), DAD1(1), DHDDS(1), FUT8(1), GANAB(2), MAN2A1(1), MGAT2(1), MGAT3(2), MGAT5(1), MGAT5B(1), STT3B(2) 18273572 17 16 17 5 3 4 1 5 4 0 0.602 1.000 1.000 483 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 CLOCK(1), ETV6(2), HSPA8(2), IDI1(1), NCKAP1(2), NCOA4(2), PER1(2), PER2(1), SF3A3(1), TUBB3(1) 15750114 15 15 15 6 3 4 0 5 3 0 0.764 1.000 1.000 484 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 FBP2(1), G6PC(3), GANAB(2), HK1(3), HK3(1), LCT(2), MGAM(3), PGM3(1) 14071914 16 15 16 6 8 4 0 3 1 0 0.462 1.000 1.000 485 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 37 BCR(1), DAG1(1), MAPK1(1), NFAT5(2), NFKBIA(1), PI3(1), PLCG2(4), RAF1(1), SHC1(1), SOS2(1), VAV1(3) 21108280 17 16 17 5 5 4 0 5 3 0 0.391 1.000 1.000 486 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 CTCFL(1), DOT1L(1), EHMT1(1), EHMT2(1), EZH1(1), FBXO11(1), HCFC1(2), JMJD6(1), KDM6A(1), MEN1(1), MLL(4), MLL2(9), MLL3(5), MLL5(2), OGT(5), PPP1CB(1), PRDM2(2), PRDM9(4), PRMT5(2), PRMT8(1), SATB1(1), SETD2(4), SETD8(1), SETMAR(2), STK38(1), SUV39H1(1), SUV420H1(1), SUZ12(1) 51182218 58 51 58 11 10 14 2 16 16 0 0.0753 1.000 1.000 487 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTN3(1), SPTAN1(2), TLN1(3) 12318025 6 6 6 4 2 0 0 3 1 0 0.922 1.000 1.000 488 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(2), ATP4A(3), ATP6V0A2(1), ATP6V1C2(1), ATP6V1D(1), COX7B(1), NDUFA3(1), NDUFS1(1), NDUFS3(1), NDUFV2(1), SDHA(3), SDHC(1), TCIRG1(1), UQCRC1(1), UQCRH(1) 24042366 20 17 19 6 7 5 0 3 5 0 0.573 1.000 1.000 489 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(3), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A3(1), ALDH3A1(3), ALDH3B2(1), AOX1(2), DBH(1), DDC(1), HGD(2), TAT(1), TH(1), TPO(3), TYR(2) 13673039 26 25 26 10 9 5 2 6 4 0 0.503 1.000 1.000 490 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 IL4R(1), IRS1(2), JAK3(1), MAPK1(1), PDK1(2), RAF1(1), SHC1(1), SOS2(1), STAT6(2) 14150253 12 11 12 7 2 2 0 6 2 0 0.895 1.000 1.000 491 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 62 ATR(1), BAI1(1), BAX(1), CCNB1(1), CCNB2(1), CCNB3(1), CCNE2(1), CCNG2(1), CDKN2A(1), CHEK2(1), CYCS(1), DDB2(1), GTSE1(1), MDM2(2), MDM4(1), RFWD2(2), SESN3(1), SIAH1(1), THBS1(1), TSC2(2), ZMAT3(1) 27429788 24 24 24 7 4 7 0 7 6 0 0.428 1.000 1.000 492 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDHPPT(1), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), DOT1L(1), ECHS1(1), EHMT1(1), EHMT2(1), HADHA(2), PLOD1(1) 15982905 16 14 16 8 5 3 0 3 5 0 0.706 1.000 1.000 493 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 23 EGF(3), MAPK1(1), MYLK(1), PRKACG(1), PRKAR1A(2), TLN1(3) 12976640 11 11 11 8 4 2 0 4 1 0 0.975 1.000 1.000 494 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 91 ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), EGF(3), GJA1(1), GNAI1(3), GNAS(3), GRM5(1), GUCY1A3(1), GUCY2C(2), GUCY2F(2), HTR2A(1), HTR2B(2), ITPR1(2), ITPR2(4), ITPR3(4), KRAS(1), MAP2K5(1), MAPK1(1), MAPK7(3), NRAS(1), PDGFA(1), PDGFC(1), PDGFD(1), PDGFRA(7), PLCB1(2), PLCB2(3), PLCB4(1), PRKACG(1), PRKCA(1), PRKCG(1), PRKG2(1), RAF1(1), SOS2(1), TJP1(3), TUBA3C(2), TUBA3D(1), TUBB3(1), TUBB6(1), TUBB8(1) 55901821 77 63 77 17 24 16 2 17 18 0 0.0511 1.000 1.000 495 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(1), ACADS(2), ACADVL(1), ACAT2(1), ACOX3(1), ACSL1(3), ACSL4(1), ACSL6(1), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), CYP4A11(1), CYP4A22(1), ECHS1(1), HADHA(2), HSD17B4(2) 21087760 30 28 30 10 8 5 0 7 10 0 0.492 1.000 1.000 496 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 BAX(1), CASP1(1), CRADD(1), CYCS(1), FASLG(1), IKBKE(2), NFKBIA(1), NR3C1(1), RIPK1(1), TNF(1), TRADD(1) 18716575 12 12 12 8 4 2 0 3 3 0 0.941 1.000 1.000 497 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACTB(1), ACTG1(1), ACTN3(1), ACTN4(1), ACVR1C(1), CDH1(1), CREBBP(4), CSNK2A1(1), CTNNA2(1), CTNNA3(1), CTNNB1(1), ERBB2(1), FARP2(1), IGF1R(2), IQGAP1(2), LMO7(1), MAPK1(1), MET(4), MLLT4(1), PTPRB(2), PTPRF(2), PTPRJ(2), PTPRM(2), PVRL3(1), RAC2(1), SMAD2(1), SMAD3(1), TCF7L2(2), TGFBR1(1), TGFBR2(1), TJP1(3), VCL(1), WAS(2), WASF3(2), YES1(1) 50469739 52 49 52 10 15 15 1 9 12 0 0.0221 1.000 1.000 498 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDT1(1), DIAPH2(1), MCM10(1), MCM6(1), MCM7(1), POLD1(1), POLE(1), PRIM1(1), RFC1(1), RPA1(1), UBC(2) 21782990 12 9 12 7 3 2 0 2 5 0 0.947 1.000 1.000 499 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(2), CANT1(3), CTPS2(1), DCTD(1), DHODH(1), DPYS(2), NT5C(2), NT5E(1), POLD1(1), POLE(1), POLQ(2), POLR2A(1), POLR2B(1), POLR2G(1), RRM1(1), TK2(1), UCK1(1), UMPS(1) 24720875 24 23 24 9 7 7 2 2 6 0 0.662 1.000 1.000 500 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 GTF2E1(1), GTF2H4(1), POLR1A(1), POLR2A(1), POLR2B(1), POLR2G(1), POLR3B(1), POLR3D(1), POLR3K(1), TAF6(1) 15095612 10 10 10 9 3 4 1 1 1 0 0.974 1.000 1.000 501 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 82 CD1B(2), CD1E(2), CD22(2), CD36(1), CD44(2), CR1(3), CR2(2), CSF2RA(3), DNTT(1), FCGR1A(1), HLA-DRA(1), HLA-DRB5(2), IL1R1(1), IL1R2(1), IL4R(1), IL6(1), IL7R(1), IL9R(2), ITGA2(1), ITGA2B(1), ITGA4(1), ITGA5(1), KIT(2), MS4A1(1), TFRC(2), TNF(1), TPO(3) 35076777 42 37 42 12 11 15 1 11 4 0 0.147 1.000 1.000 502 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(2), C3(6), C4BPA(1), C4BPB(1), C6(1), C7(2), C8A(2), C8B(1), CD46(1), CFH(4), CR1(3), CR2(2), F13A1(2), F13B(1), F2(3), F5(4), F7(1), F8(3), FGA(1), FGB(1), FGG(1), KLKB1(3), MBL2(2), PROS1(1), SERPING1(2), VWF(3) 38953548 54 48 54 15 19 15 1 8 11 0 0.127 1.000 1.000 503 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 32 FOS(1), IL2RB(2), IRS1(2), JAK3(1), MAPK1(1), RAF1(1), SHC1(1), STAT5B(1) 13984653 10 10 10 8 1 4 0 4 1 0 0.956 1.000 1.000 504 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(1), CAD(2), CANT1(3), CTPS2(1), DCTD(1), DHODH(1), DPYS(2), ENTPD5(1), ENTPD6(1), NT5C(2), NT5E(1), POLA1(2), POLD1(1), POLE(1), POLR1A(1), POLR2A(1), POLR2B(1), POLR2G(1), POLR3A(3), POLR3B(1), POLR3GL(1), POLR3K(1), PRIM1(1), PRIM2(2), RRM1(1), TK2(1), TXNRD2(1), UCK1(1), UMPS(1), UPRT(1) 34838967 39 38 39 10 6 11 4 7 11 0 0.308 1.000 1.000 505 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 67 KDR(4), KRAS(1), MAPK1(1), MAPK12(1), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), NOS3(3), NRAS(1), PIK3CG(2), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PLCG1(4), PLCG2(4), PPP3R2(1), PRKCA(1), PRKCG(1), PTGS2(1), RAC2(1), RAF1(1), SH2D2A(1) 29486504 42 37 41 12 13 13 1 9 6 0 0.166 1.000 1.000 506 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 ABO(1), B3GNT3(1), B3GNT4(1), B3GNT5(2), B4GALNT1(1), FUT5(1), PIGB(1), PIGS(1), PIGZ(1), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1), ST3GAL6(1), ST6GALNAC3(1), ST8SIA5(1) 20939560 16 16 16 7 4 3 1 5 3 0 0.775 1.000 1.000 507 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(1), BRAF(3), FOS(1), MAP2K3(1), MAP2K5(1), MAP2K6(1), MAP3K1(2), MAP3K10(1), MAP3K12(2), MAP3K13(1), MAP3K4(2), MAP3K5(2), MAP4K4(1), MAPK1(1), MAPK12(1), MAPK4(1), MAPK7(3), MAPK8(1), MAPK9(1), MAPKAPK5(2), MAX(3), MKNK1(1), NFKBIA(1), PAK1(1), RAF1(1), RIPK1(1), RPS6KA1(1), RPS6KA3(1), SHC1(1), TGFBR1(1), TRADD(1) 41061360 42 38 41 10 7 14 0 10 11 0 0.208 1.000 1.000 508 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 82 ABL2(1), BRAF(3), BTC(1), CBLB(1), CBLC(1), CDKN1B(1), EGF(3), ERBB2(1), ERBB3(1), ERBB4(1), HBEGF(1), KRAS(1), MAPK1(1), MAPK8(1), MAPK9(1), NCK1(1), NRAS(1), NRG1(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PIK3CG(2), PIK3R5(1), PLCG1(4), PLCG2(4), PRKCA(1), PRKCG(1), RAF1(1), SHC1(1), SOS2(1), STAT5B(1) 41686649 43 41 42 10 11 10 1 13 8 0 0.174 1.000 1.000 509 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP6(1), ARPC1B(1), CFL1(1), DIAPH1(2), LIMK1(3), MYLK(1), OPHN1(2), TLN1(3), VCL(1) 19549533 15 15 15 6 4 3 0 6 2 0 0.709 1.000 1.000 510 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(3), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A3(1), ALDH3A1(3), ALDH3B2(1), AOX1(2), DBH(1), DDC(1), ESCO2(1), HGD(2), PRMT5(2), PRMT8(1), TAT(1), TH(1), TPO(3), TYR(2), TYRP1(2) 25611800 32 29 32 10 9 8 3 6 6 0 0.345 1.000 1.000 511 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 FBP2(1), GMDS(1), HK1(3), HK3(1), HSD3B7(1), MTMR6(1), PFKL(1), TSTA3(1) 16074771 10 10 10 5 3 5 0 1 1 0 0.675 1.000 1.000 512 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 AR(1), ESR2(2), NR1H3(1), NR3C1(1), NR4A1(1), NR5A2(1), PPARG(1), RXRA(1), RXRG(3), THRA(1) 18191302 13 11 13 8 4 3 1 3 2 0 0.948 1.000 1.000 513 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 44 BCR(1), CD22(2), CR2(2), DAG1(1), FLOT1(1), FLOT2(2), ITPR1(2), ITPR2(4), ITPR3(4), MAPK1(1), NFATC1(1), NFATC2(2), PDK1(2), PLCG2(4), PTPRC(3), RAF1(1), SHC1(1), SOS2(1), VAV1(3) 30249701 38 35 38 12 13 9 1 13 2 0 0.349 1.000 1.000 514 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 89 CARD11(3), CBLB(1), CBLC(1), CD28(1), CTLA4(1), FOS(1), KRAS(1), LAT(1), NCK1(1), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), NFKBIA(1), NRAS(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PDK1(2), PIK3CG(2), PIK3R5(1), PLCG1(4), PPP3R2(1), PRKCQ(1), PTPRC(3), SOS2(1), TEC(1), TNF(1), VAV1(3), ZAP70(2) 41353947 45 39 44 11 14 13 1 11 6 0 0.102 1.000 1.000 515 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 DLG4(1), LPA(1), MAP3K1(2), MAP3K5(2), MAPK8(1), NFKBIA(1), PDK1(2), PHKA2(2), PI3(1), PLD1(3), RDX(1), ROCK2(1), SRF(1) 21109372 19 19 19 7 3 4 2 8 2 0 0.749 1.000 1.000 516 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 BAX(1), CASP1(1), CYCS(1), FASLG(1), MAP3K1(2), MDM2(2), NFKBIA(1), PLEKHG5(1), PRF1(1), RIPK1(1), TNF(1), TRADD(1) 24376500 14 14 14 9 4 3 0 4 3 0 0.947 1.000 1.000 517 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(1), CTNNB1(1), DVL2(1), FZD10(1), FZD5(1), FZD6(1), FZD7(1), FZD9(1), MAPK9(1), PAFAH1B1(2), PPP2R5E(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(1), WNT11(2), WNT16(1), WNT2(1), WNT7A(1) 25956401 21 20 21 8 10 2 0 4 5 0 0.617 1.000 1.000 518 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(1), BRAF(3), CALML3(1), CREBBP(4), GRIA1(5), GRIN1(1), GRIN2A(3), GRIN2B(3), GRIN2C(2), GRIN2D(2), GRM5(1), ITPR1(2), ITPR2(4), ITPR3(4), KRAS(1), MAPK1(1), NRAS(1), PLCB1(2), PLCB2(3), PLCB4(1), PPP1CB(1), PPP3R2(1), PRKACG(1), PRKCA(1), PRKCG(1), RAF1(1), RPS6KA1(1), RPS6KA3(1), RPS6KA6(1) 42943445 54 52 54 16 14 12 3 18 7 0 0.329 1.000 1.000 519 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 76 ANGPTL2(1), ARHGEF6(2), BRAF(3), CDKN2A(1), DOCK1(1), GRB7(1), ITGA10(1), ITGA11(2), ITGA2(1), ITGA4(1), ITGA5(1), ITGA8(1), MAPK1(1), MAPK8(1), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), MYLK(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PKLR(1), PLCG1(4), PLCG2(4), RAF1(1), RALA(1), ROCK2(1), SHC1(1), SOS2(1), TLN1(3), TLN2(1), WAS(2) 51432792 46 41 45 10 11 10 1 15 9 0 0.129 1.000 1.000 520 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASDHPPT(1), ACAT2(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), DOT1L(1), ECHS1(1), EHMT1(1), EHMT2(1), HADHA(2), HSD17B4(2), HSD3B7(1), OGDHL(1), PLOD1(1), SUV39H1(1) 25064303 21 19 21 8 7 2 0 6 6 0 0.612 1.000 1.000 521 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), CALML3(1), CREB3(3), CREBBP(4), CTNNB1(1), DVL2(1), FZD10(1), FZD5(1), FZD6(1), FZD7(1), FZD9(1), GNAI1(3), GNAO1(3), GNAS(3), KIT(2), KRAS(1), MAPK1(1), NRAS(1), PLCB1(2), PLCB2(3), PLCB4(1), PRKACG(1), PRKCA(1), PRKCG(1), RAF1(1), TCF7L2(2), TYR(2), TYRP1(2), WNT11(2), WNT16(1), WNT2(1), WNT7A(1), WNT8A(1), WNT9B(1) 47099701 62 54 62 16 24 7 0 15 16 0 0.220 1.000 1.000 522 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 42 CREBBP(4), DTX1(1), DVL2(1), HDAC2(3), MAML1(2), MAML2(2), MFNG(1), NCOR2(3), NCSTN(1), NOTCH2(5), NOTCH3(4), NOTCH4(5), NUMBL(2), RBPJ(4), RBPJL(1) 28211878 39 36 39 13 10 6 1 6 15 1 0.698 1.000 1.000 523 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(1), IL6ST(2), RPL23(1), RPL7(1), RPL7A(1), RPS2(1), RPS24(1), RPS4X(1), RPS6KA1(1), RPS6KA3(1), RPS6KA6(1), SLC36A2(1), UBC(2) 22538352 15 15 15 6 0 4 1 8 2 0 0.832 1.000 1.000 524 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 ABP1(3), ACAT2(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), AOX1(2), CYP1A2(2), DDC(1), ECHS1(1), HADHA(2), HSD17B4(2), LNX1(1), NFX1(1), OGDHL(1), PRMT5(2), PRMT8(1), TDO2(1), WARS2(1) 26107442 29 28 29 10 11 9 1 4 4 0 0.380 1.000 1.000 525 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN3(1), BCR(1), MAPK1(1), MAPK8(1), RAF1(1), SHC1(1), TLN1(3), VCL(1) 20351425 10 10 10 6 1 3 0 5 1 0 0.914 1.000 1.000 526 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 ALG13(1), ALG14(1), ALG6(1), B3GNT7(1), C1GALT1(1), CHPF(1), CHST1(1), CHST11(1), CHST13(1), CHSY1(1), DAD1(1), EXT1(1), EXT2(1), EXTL1(2), FUT8(1), GALNT1(1), GALNT14(1), GALNT4(1), GALNT5(1), GALNT6(1), GALNTL1(1), GALNTL4(1), GALNTL5(1), GANAB(2), HS3ST3A1(1), HS6ST2(2), MAN2A1(1), MGAT2(1), MGAT3(2), MGAT5(1), MGAT5B(1), NDST2(1), NDST3(2), OGT(5), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1), ST6GALNAC1(1), STT3B(2), WBSCR17(4), XYLT1(2) 47592682 55 48 55 14 17 12 3 14 9 0 0.205 1.000 1.000 527 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 65 AGTR2(1), ATP8A1(1), AVPR1A(2), BRS3(1), CCR10(1), CCR7(1), CXCR4(1), FPR1(1), FSHR(1), GALR1(1), GNRHR(1), GRPR(3), MC3R(1), MC4R(1), MC5R(1), NMBR(2), NPY1R(1), NPY2R(1), OPRD1(1), PPYR1(1), SSTR2(1), SSTR3(2), TACR2(2), TACR3(1), TSHR(2) 22261386 32 29 32 13 12 9 1 8 2 0 0.480 1.000 1.000 528 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 70 CALML3(1), DGKA(1), DGKD(2), DGKH(1), DGKQ(1), FN3K(1), INPP4B(1), INPPL1(1), ITPR1(2), ITPR2(4), ITPR3(4), OCRL(2), PI4KA(2), PI4KB(2), PIK3C2B(1), PIK3CG(2), PIK3R5(1), PIP4K2B(1), PIP4K2C(2), PLCB1(2), PLCB2(3), PLCB4(1), PLCD3(2), PLCE1(3), PLCG1(4), PLCG2(4), PLCZ1(1), PRKCA(1), PRKCG(1), PTPMT1(1), SYNJ1(1), SYNJ2(3) 51754544 59 56 58 15 19 15 2 13 10 0 0.200 1.000 1.000 529 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 DARS2(1), EPRS(1), FARS2(2), GARS(1), HARS(1), IARS2(1), LARS(1), MARS2(1), RARS(1), RARS2(2), WARS2(1) 23363114 13 12 13 8 1 7 0 4 1 0 0.932 1.000 1.000 530 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR1C(1), ACVR2A(2), ACVRL1(2), BMP4(2), BMPR1B(1), CREBBP(4), CUL1(1), DCN(1), GDF6(1), LEFTY2(1), LTBP1(1), MAPK1(1), PITX2(1), PPP2R2C(1), ROCK2(1), SMAD1(1), SMAD2(1), SMAD3(1), SMAD5(1), SMAD6(1), SMAD9(1), SMURF2(1), TGFBR1(1), TGFBR2(1), THBS1(1), THBS2(1), THBS4(1), TNF(1) 42787774 34 31 34 10 11 10 2 6 5 0 0.253 1.000 1.000 531 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 41 ANGPTL2(1), CFL1(1), GDI1(2), INPPL1(1), ITPR1(2), ITPR2(4), ITPR3(4), LIMK1(3), MYLK(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PDK1(2), PIK3CG(2), PITX2(1), ROCK2(1), RPS4X(1), SAG(1) 28233139 31 29 31 11 6 10 2 11 2 0 0.584 1.000 1.000 532 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 96 CXCL9(1), FOS(1), IFNA21(1), IFNA5(1), IFNAR1(2), IKBKE(2), IL12B(1), IL6(1), IRAK4(1), LBP(1), MAP2K3(1), MAP2K6(1), MAPK1(1), MAPK12(1), MAPK8(1), MAPK9(1), NFKBIA(1), PIK3CG(2), PIK3R5(1), RIPK1(1), SPP1(1), TBK1(1), TICAM1(1), TLR1(3), TLR2(1), TLR3(1), TLR5(1), TLR6(2), TLR7(2), TLR9(2), TNF(1), TOLLIP(1) 37068563 40 39 40 14 10 13 2 9 6 0 0.430 1.000 1.000 533 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), ADRA1B(1), ADRB2(1), ANXA6(1), ARRB2(1), ATP2B2(1), ATP2B3(3), CACNA1A(2), CACNA1B(4), CACNA1D(1), CACNA1E(6), CACNA1S(5), CACNB3(1), CALR(1), CASQ2(1), CHRM1(1), CHRM3(3), CHRM5(1), GJA1(1), GJB2(1), GJB6(1), GNAO1(3), GNB2(1), GNG12(1), GRK4(1), ITPR1(2), ITPR2(4), ITPR3(4), KCNB1(3), MYCBP(1), PEA15(1), PRKAR1A(2), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(1), RGS19(1), RGS3(4), RGS6(1), RGS9(1), RYR1(7), RYR2(10), RYR3(3), SLC8A3(2), YWHAH(1) 80909542 104 75 103 28 34 23 4 24 19 0 0.106 1.000 1.000 534 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(3), AMY2B(1), DDX4(2), DDX51(2), DDX52(1), DDX55(1), DDX56(1), ENPP1(1), ENPP3(2), G6PC(3), G6PC2(1), GANC(1), HK1(3), HK3(1), IFIH1(2), MGAM(3), MOV10L1(1), PGM3(1), PYGB(1), PYGL(1), RAD54L(1), RUVBL2(1), SETX(3), SI(4), SKIV2L2(1), UGT1A1(3), UGT2A3(1), UGT2B10(4), UGT2B11(3), UGT2B28(2), UGT2B4(1), UGT2B7(1), UXS1(2) 53282909 59 52 59 17 17 18 0 17 7 0 0.231 1.000 1.000 535 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVRL1(2), BUB1(1), CLK1(1), CLK4(1), CSNK2A1(1), DGKA(1), DGKD(2), DGKH(1), DGKQ(1), INPP4B(1), INPPL1(1), MAP3K10(1), OCRL(2), PAK4(1), PIK3C2B(1), PIK3CG(2), PLCB1(2), PLCB2(3), PLCB4(1), PLCG1(4), PLCG2(4), PRKACG(1), PRKAR1A(2), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(1), RAF1(1), RPS6KA1(1), RPS6KA3(1), TGFBR1(1), VRK1(2) 47688977 47 42 46 14 14 15 1 11 6 0 0.349 1.000 1.000 536 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 122 BRAF(3), CD244(1), FASLG(1), HLA-G(2), ICAM1(1), IFNA21(1), IFNA5(1), IFNAR1(2), IFNGR2(1), ITGAL(2), ITGB2(1), KIR2DL1(3), KLRC2(1), KRAS(1), LAT(1), MAPK1(1), MICA(1), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), NRAS(1), PAK1(1), PIK3CG(2), PIK3R5(1), PLCG1(4), PLCG2(4), PPP3R2(1), PRF1(1), PRKCA(1), PRKCG(1), PTK2B(1), RAC2(1), RAF1(1), SH2D1A(1), SH2D1B(1), SH3BP2(1), SHC1(1), SOS2(1), TNF(1), TNFRSF10C(1), ULBP1(1), VAV1(3), ZAP70(2) 45981770 63 57 62 23 18 18 1 16 10 0 0.451 1.000 1.000 537 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 187 ACTB(1), ACTG1(1), ACTN3(1), ACTN4(1), BRAF(3), COL11A1(1), COL1A2(5), COL2A1(1), COL3A1(3), COL4A1(1), COL4A4(1), COL4A6(3), COL5A1(1), COL5A2(1), COL6A3(6), COL6A6(1), CTNNB1(1), DIAPH1(2), DOCK1(1), EGF(3), ERBB2(1), FARP2(1), FLNA(3), FLNB(4), FLNC(4), HGF(2), IBSP(1), IGF1R(2), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(1), ITGA4(1), ITGA5(1), ITGA8(1), ITGB6(1), ITGB7(1), ITGB8(1), KDR(4), LAMA1(3), LAMA2(3), LAMA3(8), LAMA4(1), LAMA5(5), LAMB1(1), LAMB4(3), LAMC1(1), LAMC2(1), LAMC3(2), MAPK1(1), MAPK8(1), MAPK9(1), MET(4), MYLK(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PARVB(1), PDGFA(1), PDGFC(1), PDGFD(1), PDGFRA(7), PGF(1), PIK3CG(2), PIK3R5(1), PPP1CB(1), PRKCA(1), PRKCG(1), RAC2(1), RAF1(1), RAPGEF1(2), RELN(4), ROCK2(1), SHC1(1), SOS2(1), SPP1(1), THBS1(1), THBS2(1), THBS4(1), TLN1(3), TLN2(1), TNC(2), TNN(2), TNR(1), TNXB(4), VAV1(3), VCL(1), VEGFB(2), VEGFC(2), VWF(3) 156268470 168 122 167 60 54 46 5 39 24 0 0.267 1.000 1.000 538 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 167 ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY7(1), ADCY9(2), ADRA1B(1), ADRB2(1), ATP2B2(1), ATP2B3(3), AVPR1A(2), CACNA1A(2), CACNA1B(4), CACNA1D(1), CACNA1E(6), CACNA1F(3), CACNA1G(1), CACNA1H(2), CACNA1I(1), CACNA1S(5), CALML3(1), CHRM1(1), CHRM3(3), CHRM5(1), ERBB2(1), ERBB3(1), ERBB4(1), GNAS(3), GRIN1(1), GRIN2A(3), GRIN2C(2), GRIN2D(2), GRM5(1), GRPR(3), HRH1(1), HTR2A(1), HTR2B(2), HTR4(1), HTR5A(1), ITPR1(2), ITPR2(4), ITPR3(4), MYLK(1), NOS1(1), NOS3(3), P2RX1(1), P2RX2(1), P2RX3(1), P2RX4(1), PDE1A(1), PDE1B(1), PDE1C(1), PDGFRA(7), PHKA2(2), PHKB(1), PLCB1(2), PLCB2(3), PLCB4(1), PLCD3(2), PLCE1(3), PLCG1(4), PLCG2(4), PLCZ1(1), PPP3R2(1), PRKACG(1), PRKCA(1), PRKCG(1), PTAFR(1), PTK2B(1), RYR1(7), RYR2(10), RYR3(3), SLC25A5(1), SLC8A3(2), TACR2(2), TACR3(1), VDAC3(2) 115150283 158 114 157 50 49 41 4 34 30 0 0.228 1.000 1.000 539 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 235 ADCYAP1R1(2), ADRA1B(1), ADRB2(1), AGTR2(1), AVPR1A(2), BRS3(1), CALCR(1), CHRM1(1), CHRM3(3), CHRM5(1), CTSG(1), DRD5(3), F2(3), F2RL1(2), FPR1(1), FSHR(1), GABRA1(3), GABRA3(2), GABRA4(3), GABRA5(1), GABRA6(3), GABRB1(2), GABRB2(2), GABRB3(1), GABRE(2), GABRG2(1), GABRG3(1), GABRP(1), GALR1(1), GH1(1), GHR(1), GIPR(1), GLP2R(1), GLRA1(1), GLRB(1), GNRHR(1), GPR156(1), GPR35(1), GPR50(2), GPR83(1), GRIA1(5), GRIA3(4), GRID2(1), GRIK2(1), GRIK4(1), GRIN1(1), GRIN2A(3), GRIN2B(3), GRIN2C(2), GRIN2D(2), GRIN3A(1), GRM3(1), GRM4(3), GRM5(1), GRM6(2), GRM7(2), GRPR(3), HCRTR2(1), HRH1(1), HRH4(1), HTR1B(2), HTR1E(1), HTR2A(1), HTR2B(2), HTR4(1), HTR5A(1), MC3R(1), MC4R(1), MC5R(1), MCHR2(1), MTNR1A(1), NMBR(2), NMUR2(1), NPY1R(1), NPY2R(1), NR3C1(1), OPRD1(1), P2RX1(1), P2RX2(1), P2RX3(1), P2RX4(1), P2RY2(1), P2RY6(1), PPYR1(1), PTAFR(1), PTH2R(1), RXFP2(2), SCTR(1), SSTR2(1), SSTR3(2), TAAR5(1), TACR2(2), TACR3(1), THRA(1), TSHR(2), UTS2R(1) 95356142 142 108 142 46 54 34 2 33 19 0 0.108 1.000 1.000 540 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 244 ACVR1C(1), ARRB2(1), ATF2(1), BRAF(3), CACNA1A(2), CACNA1B(4), CACNA1D(1), CACNA1E(6), CACNA1F(3), CACNA1G(1), CACNA1H(2), CACNA1I(1), CACNA1S(5), CACNA2D3(1), CACNA2D4(1), CACNB2(1), CACNB3(1), CACNG3(3), CACNG7(1), CACNG8(1), CDC25B(1), DDIT3(1), DUSP16(1), DUSP5(2), EGF(3), FASLG(1), FGF4(1), FGF5(2), FGF6(1), FGF7(1), FGFR2(1), FGFR4(1), FLNA(3), FLNB(4), FLNC(4), FOS(1), GNG12(1), IL1R1(1), IL1R2(1), KRAS(1), MAP2K3(1), MAP2K5(1), MAP2K6(1), MAP3K1(2), MAP3K10(1), MAP3K12(2), MAP3K13(1), MAP3K4(2), MAP3K5(2), MAP4K4(1), MAPK1(1), MAPK12(1), MAPK7(3), MAPK8(1), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), MAPKAPK5(2), MAX(3), MKNK1(1), NFATC2(2), NFATC4(1), NR4A1(1), NRAS(1), PAK1(1), PDGFA(1), PDGFRA(7), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PPM1B(1), PPP3R2(1), PRKACG(1), PRKCA(1), PRKCG(1), PTPN5(1), PTPRR(2), RAC2(1), RAF1(1), RASA1(2), RASGRF2(2), RASGRP2(1), RASGRP4(1), RPS6KA1(1), RPS6KA3(1), RPS6KA6(1), RRAS(1), SOS2(1), SRF(1), STK3(1), TAOK1(2), TGFBR1(1), TGFBR2(1), TNF(1) 119543651 150 106 149 57 35 47 3 32 33 0 0.681 1.000 1.000 541 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(1), ACTG1(1), COL11A1(1), COL17A1(1), COL1A2(5), COL2A1(1), COL3A1(3), COL4A1(1), COL4A4(1), COL4A6(3), COL5A1(1), COL5A2(1), COL6A3(6), COL6A6(1), DSC1(1), DSC2(1), DSC3(2), DSG1(2), DSG2(3), DSG3(2), DSG4(1), GJA1(1), GJA3(1), GJA8(1), GJB2(1), GJB6(1), GJC3(1), IBSP(1), KRT15(2), KRT16(1), KRT17(1), KRT20(3), KRT27(1), KRT28(2), KRT3(3), KRT31(2), KRT33A(2), KRT33B(2), KRT34(1), KRT35(1), KRT36(1), KRT37(2), KRT39(1), KRT6B(1), KRT6C(2), KRT71(1), KRT73(2), KRT75(1), KRT76(1), KRT8(1), KRT83(2), KRT84(1), KRT86(1), KRT9(1), LAMA1(3), LAMA2(3), LAMA3(8), LAMA4(1), LAMA5(5), LAMB1(1), LAMB4(3), LAMC1(1), LAMC2(1), LAMC3(2), LMNA(1), LMNB2(1), NES(1), RELN(4), SPP1(1), THBS1(1), THBS2(1), THBS4(1), TNC(2), TNN(2), TNR(1), TNXB(4), VWF(3) 107479881 136 103 136 53 59 35 3 28 11 0 0.445 1.000 1.000 542 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 199 ACTN3(1), ACTN4(1), APC(1), ARHGEF12(1), ARHGEF4(2), ARHGEF6(2), ARPC1B(1), BRAF(3), CFL1(1), CHRM1(1), CHRM3(3), CHRM5(1), CYFIP2(1), DIAPH1(2), DIAPH2(1), DIAPH3(1), DOCK1(1), EGF(3), F2(3), FGF4(1), FGF5(2), FGF6(1), FGF7(1), FGFR2(1), FGFR4(1), GNG12(1), IQGAP1(2), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(1), ITGA4(1), ITGA5(1), ITGA8(1), ITGAD(1), ITGAE(1), ITGAL(2), ITGAX(1), ITGB2(1), ITGB6(1), ITGB7(1), ITGB8(1), KRAS(1), LIMK1(3), MAPK1(1), MYH10(2), MYH14(2), MYLK(1), NCKAP1(2), NCKAP1L(2), NRAS(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PDGFA(1), PDGFRA(7), PFN4(1), PIK3CG(2), PIK3R5(1), PIP4K2B(1), PIP4K2C(2), PPP1CB(1), RAC2(1), RAF1(1), RDX(1), ROCK2(1), RRAS(1), SCIN(1), SOS2(1), SSH1(1), TIAM1(2), TIAM2(2), VAV1(3), VCL(1), WAS(2) 115754655 110 96 110 44 23 27 4 34 22 0 0.791 1.000 1.000 543 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 CD36(1), CD44(2), COL11A1(1), COL1A2(5), COL2A1(1), COL3A1(3), COL4A1(1), COL4A4(1), COL4A6(3), COL5A1(1), COL5A2(1), COL6A3(6), COL6A6(1), DAG1(1), FNDC1(2), FNDC3A(2), HSPG2(6), IBSP(1), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(1), ITGA4(1), ITGA5(1), ITGA8(1), ITGB6(1), ITGB7(1), ITGB8(1), LAMA1(3), LAMA2(3), LAMA3(8), LAMA4(1), LAMA5(5), LAMB1(1), LAMB4(3), LAMC1(1), LAMC2(1), LAMC3(2), RELN(4), SDC1(1), SPP1(1), THBS1(1), THBS2(1), THBS4(1), TNC(2), TNN(2), TNR(1), TNXB(4), VWF(3) 96715339 99 80 99 39 38 33 3 17 8 0 0.394 1.000 1.000 544 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 249 ACVR2A(2), BMPR1B(1), CCL20(1), CCR7(1), CD70(1), CNTFR(1), CRLF2(2), CSF2RA(3), CSF2RB(1), CXCL13(1), CXCL9(1), CXCR4(1), EDA(1), EDAR(3), EGF(3), FASLG(1), FLT4(1), GH1(1), GHR(1), HGF(2), IFNA21(1), IFNA5(1), IFNAR1(2), IFNGR2(1), IL12B(1), IL12RB1(1), IL13RA1(1), IL15(1), IL17RA(1), IL18(2), IL19(1), IL1R1(1), IL1R2(1), IL20RA(1), IL22RA1(1), IL23R(1), IL2RB(2), IL4R(1), IL6(1), IL6ST(2), IL7R(1), IL9R(2), KDR(4), KIT(2), LIFR(1), LTBR(2), MET(4), OSMR(1), PDGFC(1), PDGFRA(7), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF10C(1), TNFRSF13B(1), TNFRSF14(1), TNFRSF6B(1), TNFRSF9(2), TNFSF14(1), TNFSF15(2), TNFSF8(1), TNFSF9(1), TPO(3), VEGFB(2), VEGFC(2), XCL1(1) 75286322 100 77 99 43 20 36 4 24 16 0 0.765 1.000 1.000 545 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABLIM1(2), ABLIM3(2), ARHGEF12(1), CFL1(1), CXCR4(1), DCC(2), EFNB3(1), EPHA3(4), EPHA4(3), EPHA5(3), EPHA6(1), EPHA7(1), EPHA8(1), EPHB6(3), GNAI1(3), KRAS(1), L1CAM(1), LIMK1(3), LRRC4C(1), MAPK1(1), MET(4), NCK1(1), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), NGEF(1), NRAS(1), NTN4(1), NTNG1(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PLXNA1(2), PLXNA2(1), PLXNA3(4), PLXNB1(1), PLXNB3(1), PPP3R2(1), RAC2(1), RASA1(2), RGS3(4), RHOD(1), ROBO1(1), ROBO3(4), ROCK2(1), SEMA3A(1), SEMA3B(1), SEMA3C(1), SEMA3E(1), SEMA3F(1), SEMA4A(1), SEMA4B(1), SEMA4F(1), SEMA6A(1), SEMA6B(2), SEMA6C(1), SEMA6D(2), SEMA7A(1), SLIT1(3), SLIT2(3), SLIT3(1), SRGAP1(1), SRGAP2(1) 85317113 103 77 101 34 26 28 6 24 19 0 0.337 1.000 1.000 546 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 128 ACTB(1), ACTG1(1), ACTN3(1), ACTN4(1), AMOTL1(3), CASK(1), CLDN11(1), CLDN14(1), CLDN16(1), CLDN19(1), CSNK2A1(1), CTNNA2(1), CTNNA3(1), CTNNB1(1), CTTN(1), EPB41L1(1), EPB41L2(2), EPB41L3(2), EXOC4(2), GNAI1(3), HCLS1(1), INADL(1), JAM2(1), KRAS(1), LLGL2(1), MAGI2(2), MAGI3(1), MLLT4(1), MPDZ(3), MYH1(2), MYH10(2), MYH11(4), MYH13(5), MYH14(2), MYH15(5), MYH3(3), MYH6(2), MYH7(1), MYH7B(3), MYH8(6), NRAS(1), PPM1J(1), PPP2R2C(1), PPP2R3A(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(1), RAB3B(1), RRAS(1), SPTAN1(2), TJP1(3), YES1(1) 79745392 90 73 90 26 33 19 2 18 18 0 0.184 1.000 1.000 547 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), ADK(1), ADSL(1), ADSSL1(1), AK7(4), AMPD2(2), CANT1(3), ENPP1(1), ENPP3(2), ENTPD5(1), ENTPD6(1), GART(1), GMPR(1), GMPR2(1), GUCY1A3(1), GUCY2C(2), GUCY2F(2), IMPDH2(1), NT5C(2), NT5E(1), PAICS(1), PDE11A(2), PDE1A(1), PDE1C(1), PDE2A(1), PDE4D(1), PDE7B(1), PDE8A(3), PFAS(1), PKLR(1), POLA1(2), POLD1(1), POLE(1), POLR1A(1), POLR2A(1), POLR2B(1), POLR2G(1), POLR3A(3), POLR3B(1), POLR3GL(1), POLR3K(1), PRIM1(1), PRIM2(2), PRPS1(1), PRPS1L1(1), PRPS2(1), RRM1(1), XDH(2) 70351650 75 66 74 24 28 18 4 12 13 0 0.241 1.000 1.000 548 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 CADM1(1), CD22(2), CD276(1), CD28(1), CD58(1), CDH1(1), CDH15(1), CDH4(4), CDH5(1), CLDN11(1), CLDN14(1), CLDN16(1), CLDN19(1), CNTN2(2), CNTNAP2(2), CTLA4(1), ESAM(1), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(2), HLA-DRA(1), HLA-DRB5(2), HLA-F(2), HLA-G(2), ICAM1(1), ITGA4(1), ITGA8(1), ITGAL(2), ITGB2(1), ITGB7(1), ITGB8(1), JAM2(1), L1CAM(1), MAG(1), NCAM1(2), NEGR1(2), NEO1(2), NLGN1(1), NLGN2(1), NLGN3(3), NRCAM(2), NRXN1(1), NRXN3(1), PTPRC(3), PTPRF(2), PTPRM(2), PVR(2), PVRL3(1), SDC1(1), SELE(3), SELP(1), SELPLG(1), SIGLEC1(1), VCAN(3) 63752914 80 66 79 35 30 14 3 18 15 0 0.697 1.000 1.000 549 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA2(1), ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), ARRB2(1), ATF2(1), CACNB3(1), CNN2(1), CREB3(3), FOS(1), GJA1(1), GNB2(1), GNG12(1), GRK4(1), GUCY1A3(1), IGFBP2(1), IL6(1), ITPR1(2), ITPR2(4), ITPR3(4), NOS1(1), NOS3(3), PDE4D(1), PLCG1(4), PLCG2(4), PRKAR1A(2), PRKCA(1), PRKCH(1), PRKCQ(1), RGS19(1), RGS3(4), RGS6(1), RGS9(1), RLN1(1), RYR1(7), RYR2(10), RYR3(3), TNXB(4), YWHAH(1) 74679350 87 65 85 29 30 18 3 19 17 0 0.440 1.000 1.000 550 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA2(1), ACTN3(1), ACTN4(1), DMD(4), MYBPC2(2), MYH3(3), MYH6(2), MYH7(1), MYH8(6), MYOM1(1), NEB(10), TNNI1(1), TNNT1(1), TNNT3(2), TPM1(2), TPM2(1), TPM3(1), TTN(34) 58433085 74 60 73 30 31 15 1 19 8 0 0.702 1.000 1.000 551 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADRA1B(1), ADRB2(1), AGTR2(1), AVPR1A(2), BRS3(1), CCR10(1), CCR7(1), CHRM1(1), CHRM3(3), CHRM5(1), CMKLR1(1), CXCR4(1), DRD5(3), F2RL1(2), FPR1(1), FSHR(1), GALR1(1), GPR17(1), GPR174(1), GPR35(1), GPR50(2), GPR83(1), GPR85(1), GPR87(1), GRPR(3), HCRTR2(1), HRH1(1), HTR1B(2), HTR1E(1), HTR2A(1), HTR2B(2), HTR4(1), HTR5A(1), MC3R(1), MC4R(1), MC5R(1), MTNR1A(1), NMBR(2), NMUR2(1), NPY1R(1), NPY2R(1), OPRD1(1), OR10A5(1), OR1C1(2), OR1Q1(1), P2RY12(2), P2RY2(1), P2RY6(1), PPYR1(1), PTAFR(1), SSTR2(1), SSTR3(2) 52225978 67 57 67 32 28 15 1 16 7 0 0.737 1.000 1.000 552 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 143 APC(1), CHD8(2), CREBBP(4), CSNK1A1L(1), CSNK2A1(1), CTNNB1(1), CUL1(1), CXXC4(1), DKK2(2), DVL2(1), FZD10(1), FZD5(1), FZD6(1), FZD7(1), FZD9(1), LRP6(2), MAPK8(1), MAPK9(1), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), NKD2(1), PLCB1(2), PLCB2(3), PLCB4(1), PPP2R2C(1), PPP3R2(1), PRKACG(1), PRKCA(1), PRKCG(1), RAC2(1), ROCK2(1), SENP2(1), SFRP2(1), SIAH1(1), SMAD2(1), SMAD3(1), SOX17(3), TBL1XR1(1), TBL1Y(1), TCF7L2(2), VANGL2(1), WIF1(2), WNT11(2), WNT16(1), WNT2(1), WNT7A(1), WNT8A(1), WNT9B(1) 69471236 66 57 66 18 22 16 0 14 14 0 0.176 1.000 1.000 553 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 129 ACACA(4), ACACB(5), BRAF(3), CALML3(1), CBLB(1), CBLC(1), FASN(1), FBP2(1), FLOT1(1), FLOT2(2), G6PC(3), G6PC2(1), IRS1(2), IRS4(2), KRAS(1), LIPE(1), MAPK1(1), MAPK8(1), MAPK9(1), MKNK1(1), NRAS(1), PCK1(1), PDE3A(1), PFKL(1), PHKA2(2), PHKB(1), PIK3CG(2), PIK3R5(1), PKLR(1), PPARGC1A(1), PPP1CB(1), PPP1R3A(1), PRKAA1(1), PRKACG(1), PRKAR1A(2), PTPRF(2), PYGB(1), PYGL(1), RAF1(1), RAPGEF1(2), SHC1(1), SOS2(1), SREBF1(3), TSC1(1), TSC2(2) 67690423 67 57 67 24 23 20 1 18 5 0 0.406 1.000 1.000 554 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 147 CBLB(1), CBLC(1), CISH(1), CNTFR(1), CREBBP(4), CRLF2(2), CSF2RA(3), CSF2RB(1), GH1(1), GHR(1), IFNA21(1), IFNA5(1), IFNAR1(2), IFNGR2(1), IL12B(1), IL12RB1(1), IL13RA1(1), IL15(1), IL19(1), IL20RA(1), IL22RA1(1), IL23R(1), IL2RB(2), IL4R(1), IL6(1), IL6ST(2), IL7R(1), IL9R(2), JAK2(1), JAK3(1), LIFR(1), OSMR(1), PIAS3(1), PIK3CG(2), PIK3R5(1), PIM1(1), SOCS5(1), SOS2(1), SPRED2(1), SPRY2(1), SPRY4(1), STAT3(1), STAT5B(1), STAT6(2), TPO(3), TYK2(2) 60412150 61 55 61 25 12 14 3 21 11 0 0.783 1.000 1.000 555 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), AKAP3(1), AKAP4(4), AKAP5(1), AKAP6(3), AKAP8(2), AKAP9(4), GNAO1(3), GNB2(1), GNG12(1), ITPR1(2), KRAS(1), NRAS(1), PDE1A(1), PDE1B(1), PDE1C(1), PDE4D(1), PDE7B(1), PDE8A(3), PRKACG(1), PRKAR1A(2), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(1), RRAS(1) 50452271 50 47 50 17 18 8 1 10 13 0 0.536 1.000 1.000 556 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADK(1), ADSL(1), AMPD2(2), CANT1(3), ENPP1(1), ENPP3(2), GART(1), GUCY1A3(1), GUCY2C(2), GUCY2F(2), IMPDH2(1), NT5C(2), NT5E(1), PAICS(1), PDE1A(1), PDE4D(1), PDE6B(3), PDE6C(3), PDE7B(1), PDE8A(3), PFAS(1), PKLR(1), POLD1(1), POLE(1), POLQ(2), POLR2A(1), POLR2B(1), POLR2G(1), PRPS1(1), PRPS1L1(1), PRPS2(1), RRM1(1) 55286989 54 47 54 25 25 15 2 6 6 0 0.768 1.000 1.000 557 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 106 ACTN3(1), ACTN4(1), CDH5(1), CLDN11(1), CLDN14(1), CLDN16(1), CLDN19(1), CTNNA2(1), CTNNA3(1), CTNNB1(1), CXCR4(1), CYBB(1), ESAM(1), GNAI1(3), ICAM1(1), ITGA4(1), ITGAL(2), ITGB2(1), JAM2(1), MAPK12(1), MLLT4(1), MMP9(1), NCF2(1), PIK3CG(2), PIK3R5(1), PLCG1(4), PLCG2(4), PRKCA(1), PRKCG(1), PTK2B(1), RAC2(1), RHOH(1), ROCK2(1), SIPA1(1), VAV1(3), VCL(1) 50723533 48 44 47 23 21 9 2 10 6 0 0.770 1.000 1.000 558 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 108 ANAPC2(1), ANAPC7(1), ATR(1), BUB1(1), BUB3(1), CCNA1(2), CCNB1(1), CCNB2(1), CCNB3(1), CCNE2(1), CDC14B(2), CDC16(1), CDC25B(1), CDKN1B(1), CDKN2A(1), CDKN2C(1), CHEK2(1), CREBBP(4), CUL1(1), FZR1(1), HDAC2(3), MCM6(1), MCM7(1), MDM2(2), PLK1(1), PRKDC(3), RB1(3), SKP2(1), SMAD2(1), SMAD3(1), SMC1B(1), WEE1(1), YWHAE(1), YWHAH(1) 58039629 46 43 46 15 5 14 1 12 14 0 0.764 1.000 1.000 559 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(2), ABCA10(1), ABCA12(1), ABCA13(6), ABCA2(1), ABCA3(1), ABCA4(3), ABCA6(2), ABCA7(4), ABCA8(1), ABCB1(3), ABCB10(2), ABCB4(3), ABCB7(1), ABCC10(3), ABCC12(1), ABCC3(1), ABCC9(1), ABCD2(1), ABCG1(1), ABCG4(2), ABCG5(1), ABCG8(1), CFTR(3) 50811373 46 39 46 25 11 13 3 10 9 0 0.928 1.000 1.000 560 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 89 CAPN11(2), CAPN3(1), DOCK1(1), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(1), ITGA4(1), ITGA5(1), ITGA8(1), ITGAD(1), ITGAE(1), ITGAL(2), ITGAX(1), ITGB2(1), ITGB6(1), ITGB7(1), ITGB8(1), MAP2K3(1), MAP2K6(1), MAPK12(1), MAPK4(1), MAPK7(3), PAK1(1), PAK4(1), PAK6(1), RAC2(1), RAPGEF1(2), ROCK2(1), SHC1(1), TLN1(3), VCL(1) 57070379 40 37 40 18 13 7 0 14 6 0 0.825 1.000 1.000 561 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CDC40(1), CLK4(1), COL2A1(1), CPSF2(1), CSTF1(1), CSTF2(1), CSTF3(1), DDIT3(1), DHX16(1), DHX38(2), FUS(1), LOC440563(1), METTL3(1), PAPOLA(1), POLR2A(1), PRPF18(1), PRPF8(2), PSKH1(1), RNGTT(1), SF3A3(1), SF3B1(2), SNRPB(1), SNRPB2(1), SNRPE(1), SNRPN(1), SPOP(2), SRPK2(1), SRRM1(1), TXNL4A(1), U2AF2(2), XRN2(2) 45547694 37 36 37 12 9 11 1 9 7 0 0.585 1.000 1.000 562 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 81 BUB1(1), BUB3(1), CCNA1(2), CCNB1(1), CCNB2(1), CCNB3(1), CCNE2(1), CDC14B(2), CDC25B(1), CDH1(1), CDKN2A(1), CHEK2(1), HDAC2(3), HDAC4(2), HDAC5(1), HDAC6(2), MCM6(1), MCM7(1), MDM2(2), MPEG1(1), PLK1(1), PRKDC(3), RB1(3), SKP2(1), WEE1(1) 46892134 36 35 36 12 6 10 1 9 10 0 0.738 1.000 1.000 563 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 69 ACACB(5), ACSL1(3), ACSL4(1), ACSL6(1), ADIPOR1(1), CD36(1), G6PC(3), G6PC2(1), IRS1(2), IRS4(2), JAK2(1), JAK3(1), MAPK8(1), MAPK9(1), NFKBIA(1), NPY(2), PCK1(1), PPARGC1A(1), PRKAA1(1), PRKCQ(1), RXRA(1), RXRG(3), STAT3(1), TNF(1), TRADD(1), TYK2(2) 35329628 40 34 40 19 14 13 0 8 5 0 0.724 1.000 1.000 564 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 91 ACTB(1), CABIN1(2), CREBBP(4), CSNK2A1(1), CTLA4(1), FOS(1), GATA4(1), IL6(1), KPNA5(1), MAPK8(1), MAPK9(1), MYF5(1), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), OPRD1(1), PAK1(1), PTPRC(3), SLA(1), SP3(2), TNF(1), TRPV6(3), VAV1(3) 38486936 37 33 37 17 12 11 1 6 7 0 0.736 1.000 1.000 565 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 68 ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), AKR1C3(2), ALDH1A3(1), ALDH3A1(3), ALDH3B2(1), CYP1A2(2), CYP2B6(1), CYP2C8(1), CYP2S1(1), CYP3A4(2), CYP3A7(1), EPHX1(1), UGT1A1(3), UGT2A3(1), UGT2B10(4), UGT2B11(3), UGT2B28(2), UGT2B4(1), UGT2B7(1) 24259699 36 31 36 13 12 4 1 14 5 0 0.600 1.000 1.000 566 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 48 APOA1(1), CD36(1), CREBBP(4), HSD17B4(2), LPL(1), MAPK1(1), NCOA1(1), NCOR1(3), NCOR2(3), NFKBIA(1), NR1H3(1), PDGFA(1), PRKACG(1), PRKAR1A(2), PRKCA(1), PTGS2(1), RB1(3), RXRA(1), STAT5B(1), TNF(1) 25664654 31 30 31 12 6 9 1 6 9 0 0.758 1.000 1.000 567 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACOX3(1), ACSL1(3), ACSL4(1), ACSL6(1), APOA1(1), CD36(1), CYP4A11(1), CYP4A22(1), CYP8B1(1), FADS2(1), GK(1), GK2(3), LPL(1), MMP1(1), NR1H3(1), PCK1(1), PPARG(1), RXRA(1), RXRG(3), SLC27A4(1), UBC(2) 28202668 28 27 28 11 4 12 1 7 4 0 0.571 1.000 1.000 568 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 59 CARD11(3), CD22(2), CR2(2), FOS(1), IFITM1(1), KRAS(1), LILRB3(2), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), NFKBIA(1), NRAS(1), PIK3CG(2), PIK3R5(1), PLCG2(4), PPP3R2(1), RAC2(1), VAV1(3) 29685578 32 26 32 14 14 7 1 6 4 0 0.589 1.000 1.000 569 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP4(2), CSNK1A1L(1), CSNK1G1(1), CSNK1G2(1), GLI1(1), GLI3(1), HHIP(1), LRP2(8), PRKACG(1), PTCH1(1), RAB23(1), SHH(1), STK36(1), SUFU(1), WNT11(2), WNT16(1), WNT2(1), WNT7A(1), WNT8A(1), WNT9B(1) 26321149 29 25 29 14 12 8 1 3 5 0 0.795 1.000 1.000 570 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 53 ABP1(3), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), AOX1(2), CYP1A2(2), CYP2B6(1), CYP2C8(1), CYP3A4(2), CYP3A7(1), CYP4F8(1), DDC(1), ECHS1(1), HADHA(2), TDO2(1), WARS2(1) 23266363 27 25 27 13 12 6 0 5 4 0 0.777 1.000 1.000 571 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPP(4), ALPPL2(2), DDX4(2), DDX51(2), DDX52(1), DDX55(1), DDX56(1), FPGS(2), IFIH1(2), MOV10L1(1), QDPR(1), RAD54L(1), RUVBL2(1), SETX(3), SKIV2L2(1), SPR(1) 27040912 26 24 26 10 9 6 1 5 5 0 0.680 1.000 1.000 572 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 ARSD(1), ARSE(1), CYP11B1(1), HSD3B2(1), PRMT5(2), PRMT8(1), SRD5A1(1), SULT2B1(2), UGT1A1(3), UGT2A3(1), UGT2B10(4), UGT2B11(3), UGT2B28(2), UGT2B4(1), UGT2B7(1) 21639294 25 23 25 10 5 5 1 13 1 0 0.710 1.000 1.000 573 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 34 ACTG1(1), ANGPTL2(1), CFL1(1), FLNA(3), FLNC(4), FSCN3(2), GDI1(2), LIMK1(3), MYLK(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), ROCK2(1), RPS4X(1) 18934861 24 22 24 10 8 7 1 6 2 0 0.580 1.000 1.000 574 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS2(1), CP(1), EPRS(1), FTH1(1), HCCS(2), PPOX(1), UGT1A1(3), UGT2A3(1), UGT2B10(4), UGT2B11(3), UGT2B28(2), UGT2B4(1), UGT2B7(1) 18203707 22 21 22 10 2 7 0 13 0 0 0.843 1.000 1.000 575 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(3), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH4A1(1), ASL(1), CPS1(2), GLUD1(2), NOS1(1), NOS3(3), RARS(1) 19098778 21 20 21 14 8 5 0 3 5 0 0.960 1.000 1.000 576 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 CALR(1), CIITA(1), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(2), HLA-DRA(1), HLA-DRB5(2), HLA-F(2), HLA-G(2), IFNA21(1), IFNA5(1), KIR2DL1(3), KLRC2(1), RFXANK(1) 19913781 20 20 20 10 4 4 2 7 3 0 0.829 1.000 1.000 577 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(3), AGXT2(1), ALAS2(1), DMGDH(1), GARS(1), GLDC(1), PLCB2(3), PLCG1(4), PLCG2(4), PSPH(1) 18166996 20 19 19 10 8 6 0 4 2 0 0.800 1.000 1.000 578 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 77 BAX(1), CSF2RB(1), CYCS(1), FASLG(1), IL1R1(1), IRAK3(1), IRAK4(1), NFKBIA(1), PIK3CG(2), PIK3R5(1), PPP3R2(1), PRKACG(1), PRKAR1A(2), RIPK1(1), TNF(1), TNFRSF10C(1), TRADD(1) 34073124 19 18 19 13 3 5 1 5 5 0 0.988 1.000 1.000 579 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(1), ASL(1), ASS1(1), CPS1(2), EPRS(1), GLUD1(2), GLUD2(1), NOS1(1), NOS3(3), RARS(1), RARS2(2) 15521148 16 15 16 10 3 5 0 5 3 0 0.955 1.000 1.000 580 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(2), GPRC5C(1), GPRC5D(2), GRM3(1), GRM4(3), GRM5(1), GRM7(2) 9051312 12 12 12 8 9 1 0 2 0 0 0.891 1.000 1.000 581 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(3), AGXT2(1), ALAS2(1), DMGDH(1), GARS(1), GLDC(1), HSD3B7(1), PHGDH(2), PSPH(1) 18444475 12 12 12 10 3 3 0 5 1 0 0.973 1.000 1.000 582 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 ARSD(1), ARSE(1), CYP11B1(1), HSD3B2(1), SRD5A1(1), UGT1A1(3), UGT2B4(1) 11786478 9 9 9 5 3 1 0 5 0 0 0.867 1.000 1.000 583 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC2(1), ANAPC7(1), CDC16(1), CUL1(1), FBXW7(1), FZR1(1), SKP2(1), SMURF2(1), UBE2D4(1) 17280108 9 9 9 9 1 4 1 3 0 0 0.993 1.000 1.000 584 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1), DCN(1), FMOD(1), KERA(3), LUM(1) 1563894 7 7 7 5 1 3 0 3 0 0 0.889 1.000 1.000 585 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 34 G6PD(2), GGT1(2), GPX2(1), GSS(1) 8800697 6 6 6 4 3 2 0 1 0 0 0.826 1.000 1.000 586 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 14 MAPK1(1), PDK1(2), PTK2B(1), SHC1(1) 7498225 5 5 5 3 0 2 0 3 0 0 0.876 1.000 1.000 587 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 ARHGDIB(1), CASP1(1), CYCS(1), PRF1(1) 5538024 4 4 4 3 1 1 0 2 0 0 0.934 1.000 1.000 588 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 MYLK(1), PLCB1(2), PRKCA(1) 8878408 4 4 4 4 2 0 0 2 0 0 0.962 1.000 1.000 589 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(1), POLD1(1), PRPS2(1), RRM1(1) 5384326 4 4 4 3 2 2 0 0 0 0 0.838 1.000 1.000 590 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 RELN(4) 6036684 4 4 4 3 1 3 0 0 0 0 0.833 1.000 1.000 591 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(1), POLE(1), POLQ(2) 7174802 4 3 4 5 4 0 0 0 0 0 0.984 1.000 1.000 592 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(1), EIF2AK4(1), EIF2S2(1) 4956168 3 3 3 3 1 0 1 1 0 0 0.939 1.000 1.000 593 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 CYCS(1), FASLG(1), TNF(1) 4880765 3 3 3 4 0 1 0 2 0 0 0.995 1.000 1.000 594 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 IL6(1), STAT3(1), TNF(1) 5237079 3 3 3 3 1 1 0 1 0 0 0.951 1.000 1.000 595 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR2A(1), POLR2B(1), POLR2G(1) 5833305 3 3 3 3 1 2 0 0 0 0 0.903 1.000 1.000 596 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 DNMT1(1), MTNR1A(1), PTAFR(1) 4823811 3 3 3 3 2 1 0 0 0 0 0.929 1.000 1.000 597 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGEF2(2) 6984804 2 2 2 2 0 1 1 0 0 0 0.907 1.000 1.000 598 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 GPR34(1), GPR45(1) 4225350 2 2 2 3 1 1 0 0 0 0 0.945 1.000 1.000 599 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD58(1), IL6(1) 2654615 2 2 2 2 0 0 0 2 0 0 0.951 1.000 1.000 600 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 HLA-DRA(1), IL6(1) 2299642 2 2 2 2 0 0 0 2 0 0 0.952 1.000 1.000 601 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 MAPK8(1), TNFRSF13B(1) 6273334 2 2 2 2 0 2 0 0 0 0 0.893 1.000 1.000 602 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 14 IL6(1) 3504419 1 1 1 4 0 0 0 1 0 0 0.998 1.000 1.000 603 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 14 IL6(1) 2564187 1 1 1 2 0 0 0 1 0 0 0.979 1.000 1.000 604 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 4992904 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 605 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 3754891 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 606 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 311704 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 607 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 219003 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 608 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 1325492 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 609 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 656813 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 610 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 1 435392 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 611 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 4 2245719 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 612 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 3998853 0 0 0 3 0 0 0 0 0 0 1.000 1.000 1.000 613 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 736382 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 614 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 3758025 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 615 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 2628571 0 0 0 2 0 0 0 0 0 0 1.000 1.000 1.000 616 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 490549 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000