E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.028 0.141 -9999.0 0.0 -0.416 57.0 57.0 KLHL20 0.01 0.07 0.158 6.0 -0.213 6.0 12.0 CYFIP2 0.022 0.036 -9999.0 0.0 -0.424 3.0 3.0 Rac1/GDP -0.004 0.094 0.255 4.0 -0.258 48.0 52.0 ENAH -0.032 0.145 -9999.0 0.0 -0.408 64.0 64.0 AP1M1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.021 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.004 0.064 -9999.0 0.0 -0.182 33.0 33.0 ABI1/Sra1/Nap1 -0.014 0.035 -9999.0 0.0 -0.153 6.0 6.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.021 0.115 -9999.0 0.0 -0.257 70.0 70.0 RAPGEF1 -0.02 0.134 0.237 5.0 -0.368 57.0 62.0 CTNND1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.027 0.151 -9999.0 0.0 -0.417 65.0 65.0 CRK -0.03 0.135 0.228 1.0 -0.387 60.0 61.0 E-cadherin/gamma catenin/alpha catenin 0.014 0.104 -9999.0 0.0 -0.259 63.0 63.0 alphaE/beta7 Integrin 0.019 0.068 -9999.0 0.0 -0.301 19.0 19.0 IQGAP1 0.02 0.043 -9999.0 0.0 -0.244 10.0 10.0 NCKAP1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.037 0.024 -9999.0 0.0 -0.23 1.0 1.0 DLG1 -0.031 0.144 -9999.0 0.0 -0.414 61.0 61.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.014 0.044 -9999.0 0.0 -0.145 2.0 2.0 MLLT4 0.024 0.02 -9999.0 0.0 -0.424 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.047 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.015 0.057 -9999.0 0.0 -0.184 1.0 1.0 ARF6 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.02 0.115 -9999.0 0.0 -0.306 63.0 63.0 TIAM1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.029 0.088 -9999.0 0.0 -0.217 55.0 55.0 AKT1 -0.004 0.042 0.121 2.0 -9999.0 0.0 2.0 PIK3R1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.045 0.145 -9999.0 0.0 -0.424 59.0 59.0 RhoA/GDP 0.004 0.102 0.252 8.0 -0.257 52.0 60.0 actin cytoskeleton organization 0.014 0.06 0.161 19.0 -0.161 5.0 24.0 CDC42/GDP -0.0 0.098 0.254 5.0 -0.252 52.0 57.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.013 0.077 -9999.0 0.0 -0.22 60.0 60.0 ITGB7 0.001 0.089 -9999.0 0.0 -0.424 19.0 19.0 RAC1 0.022 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.031 0.094 -9999.0 0.0 -0.232 55.0 55.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.015 0.085 -9999.0 0.0 -0.215 59.0 59.0 mol:GDP -0.012 0.111 0.256 9.0 -0.293 53.0 62.0 CDC42/GTP/IQGAP1 0.026 0.028 -9999.0 0.0 -0.229 4.0 4.0 JUP 0.02 0.049 -9999.0 0.0 -0.381 7.0 7.0 p120 catenin/RhoA/GDP 0.008 0.104 0.257 6.0 -0.263 51.0 57.0 RAC1/GTP/IQGAP1 0.027 0.029 -9999.0 0.0 -0.253 4.0 4.0 PIP5K1C/AP1M1 0.036 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.022 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.011 0.051 0.135 21.0 -0.165 15.0 36.0 NME1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.031 0.145 -9999.0 0.0 -0.409 64.0 64.0 regulation of cell-cell adhesion -0.008 0.054 -9999.0 0.0 -0.162 33.0 33.0 WASF2 0.008 0.028 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.001 0.08 0.234 2.0 -0.2 34.0 36.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.028 0.119 -9999.0 0.0 -0.248 74.0 74.0 CCND1 0.012 0.06 0.156 17.0 -0.203 15.0 32.0 VAV2 -0.013 0.151 -9999.0 0.0 -0.445 23.0 23.0 RAP1/GDP 0.007 0.09 0.269 4.0 -0.219 49.0 53.0 adherens junction assembly -0.03 0.141 -9999.0 0.0 -0.397 64.0 64.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.016 0.112 0.202 3.0 -0.24 74.0 77.0 E-cadherin/beta catenin -0.028 0.104 -9999.0 0.0 -0.319 57.0 57.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.032 0.143 -9999.0 0.0 -0.403 64.0 64.0 PIK3CA 0.024 0.02 -9999.0 0.0 -0.424 1.0 1.0 Rac1/GTP -0.016 0.083 -9999.0 0.0 -0.329 7.0 7.0 E-cadherin/beta catenin/alpha catenin 0.017 0.099 -9999.0 0.0 -0.255 59.0 59.0 ITGAE 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.028 0.154 -9999.0 0.0 -0.426 65.0 65.0