Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.044 0.19 -9999.0 0.0 -0.577 53.0 53.0 IHH 0.011 0.056 -9999.0 0.0 -0.208 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.011 0.083 0.16 12.0 -0.232 54.0 66.0 LRPAP1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.011 0.082 0.23 54.0 -0.158 12.0 66.0 SMO/beta Arrestin2 -0.007 0.113 -9999.0 0.0 -0.401 18.0 18.0 SMO -0.019 0.111 -9999.0 0.0 -0.414 19.0 19.0 AKT1 -0.003 0.106 -9999.0 0.0 -0.478 17.0 17.0 ARRB2 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.022 0.036 -9999.0 0.0 -0.424 3.0 3.0 ADRBK1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.019 0.109 -9999.0 0.0 -0.408 19.0 19.0 STIL -0.01 0.132 0.238 3.0 -0.265 63.0 66.0 DHH N/PTCH2 0.005 0.084 -9999.0 0.0 -0.304 31.0 31.0 DHH N/PTCH1 -0.019 0.121 -9999.0 0.0 -0.301 57.0 57.0 PIK3CA 0.024 0.02 -9999.0 0.0 -0.424 1.0 1.0 DHH -0.007 0.104 -9999.0 0.0 -0.28 52.0 52.0 PTHLH -0.061 0.254 -9999.0 0.0 -0.771 53.0 53.0 determination of left/right symmetry -0.019 0.109 -9999.0 0.0 -0.408 19.0 19.0 PIK3R1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.059 0.251 -9999.0 0.0 -0.761 53.0 53.0 IHH N/Hhip -0.038 0.134 -9999.0 0.0 -0.336 75.0 75.0 DHH N/Hhip -0.048 0.138 -9999.0 0.0 -0.309 99.0 99.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.019 0.109 -9999.0 0.0 -0.408 19.0 19.0 pancreas development -0.056 0.156 -9999.0 0.0 -0.286 133.0 133.0 HHAT 0.011 0.076 -9999.0 0.0 -0.389 17.0 17.0 PI3K 0.037 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.016 0.046 -9999.0 0.0 -0.158 26.0 26.0 somite specification -0.019 0.109 -9999.0 0.0 -0.408 19.0 19.0 SHH Np/Cholesterol/PTCH1 -0.036 0.111 -9999.0 0.0 -0.275 68.0 68.0 SHH Np/Cholesterol/PTCH2 -0.016 0.081 0.157 2.0 -0.235 56.0 58.0 SHH Np/Cholesterol/Megalin -0.057 0.123 0.157 8.0 -0.266 114.0 122.0 SHH -0.029 0.096 -9999.0 0.0 -0.304 52.0 52.0 catabolic process -0.018 0.116 -9999.0 0.0 -0.339 52.0 52.0 SMO/Vitamin D3 -0.031 0.116 0.274 3.0 -0.334 33.0 36.0 SHH Np/Cholesterol/Hhip -0.046 0.118 0.159 8.0 -0.267 97.0 105.0 LRP2 -0.09 0.179 -9999.0 0.0 -0.424 106.0 106.0 receptor-mediated endocytosis -0.065 0.142 -9999.0 0.0 -0.398 47.0 47.0 SHH Np/Cholesterol/BOC -0.014 0.079 -9999.0 0.0 -0.234 54.0 54.0 SHH Np/Cholesterol/CDO -0.019 0.088 0.177 1.0 -0.247 59.0 60.0 mesenchymal cell differentiation 0.046 0.117 0.266 97.0 -0.157 8.0 105.0 mol:Vitamin D3 -0.001 0.144 0.253 5.0 -0.277 67.0 72.0 IHH N/PTCH2 0.023 0.051 -9999.0 0.0 -0.328 6.0 6.0 CDON 0.001 0.095 -9999.0 0.0 -0.34 32.0 32.0 IHH N/PTCH1 -0.01 0.12 -9999.0 0.0 -0.341 52.0 52.0 Megalin/LRPAP1 -0.05 0.135 -9999.0 0.0 -0.3 106.0 106.0 PTCH2 0.016 0.047 -9999.0 0.0 -0.274 10.0 10.0 SHH Np/Cholesterol -0.018 0.074 0.206 1.0 -0.23 52.0 53.0 PTCH1 -0.018 0.116 -9999.0 0.0 -0.34 52.0 52.0 HHIP -0.056 0.156 -9999.0 0.0 -0.286 133.0 133.0