Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.01 0.083 -9999.0 0.0 -0.224 62.0 62.0 epithelial cell differentiation 0.024 0.085 -9999.0 0.0 -0.215 55.0 55.0 CYFIP2 0.022 0.036 -9999.0 0.0 -0.424 3.0 3.0 ENAH -0.024 0.059 0.271 3.0 -9999.0 0.0 3.0 EGFR -0.017 0.123 -9999.0 0.0 -0.424 42.0 42.0 EPHA2 0.013 0.039 -9999.0 0.0 -0.424 1.0 1.0 MYO6 -0.014 0.078 0.177 19.0 -0.207 55.0 74.0 CTNNB1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.044 0.028 -9999.0 0.0 -0.239 3.0 3.0 AQP5 -0.062 0.162 0.223 3.0 -0.434 69.0 72.0 CTNND1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.014 0.076 0.175 18.0 -0.205 53.0 71.0 regulation of calcium-dependent cell-cell adhesion -0.016 0.079 0.175 18.0 -0.209 57.0 75.0 EGF -0.01 0.113 -9999.0 0.0 -0.307 54.0 54.0 NCKAP1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.019 0.1 0.223 2.0 -0.443 17.0 19.0 cortical microtubule organization 0.024 0.085 -9999.0 0.0 -0.215 55.0 55.0 GO:0000145 -0.027 0.068 0.164 18.0 -0.197 52.0 70.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.029 0.088 -9999.0 0.0 -0.217 55.0 55.0 MLLT4 0.024 0.02 -9999.0 0.0 -0.424 1.0 1.0 ARF6/GDP -0.037 0.055 -9999.0 0.0 -0.228 5.0 5.0 ARF6 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.054 0.033 -9999.0 0.0 -0.257 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.026 0.083 0.173 7.0 -0.334 18.0 25.0 PVRL2 0.02 0.023 -9999.0 0.0 -0.424 1.0 1.0 ZYX -0.013 0.068 0.177 10.0 -0.209 44.0 54.0 ARF6/GTP 0.059 0.035 -9999.0 0.0 -0.24 2.0 2.0 CDH1 -0.045 0.145 -9999.0 0.0 -0.424 59.0 59.0 EGFR/EGFR/EGF/EGF -0.02 0.118 -9999.0 0.0 -0.236 105.0 105.0 RhoA/GDP 0.026 0.082 -9999.0 0.0 -0.206 55.0 55.0 actin cytoskeleton organization -0.029 0.074 0.165 19.0 -0.211 50.0 69.0 IGF-1R heterotetramer 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.011 0.075 -9999.0 0.0 -0.424 14.0 14.0 DIAPH1 0.019 0.123 -9999.0 0.0 -0.604 6.0 6.0 Wnt receptor signaling pathway -0.024 0.085 0.215 55.0 -9999.0 0.0 55.0 RHOA 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.037 0.055 -9999.0 0.0 -0.198 35.0 35.0 CTNNA1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.029 0.075 0.167 19.0 -0.215 50.0 69.0 EFNA1 0.024 0.014 -9999.0 0.0 -0.123 4.0 4.0 LPP -0.036 0.075 0.169 17.0 -0.206 61.0 78.0 Ephrin A1/EPHA2 0.014 0.078 -9999.0 0.0 -0.2 53.0 53.0 SEC6/SEC8 -0.015 0.059 -9999.0 0.0 -0.284 3.0 3.0 MGAT3 -0.016 0.08 0.177 18.0 -0.212 57.0 75.0 HGF/MET -0.024 0.117 -9999.0 0.0 -0.246 93.0 93.0 HGF -0.009 0.089 -9999.0 0.0 -0.424 17.0 17.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.01 0.084 -9999.0 0.0 -0.225 62.0 62.0 actin cable formation -0.005 0.095 0.288 17.0 -0.253 10.0 27.0 KIAA1543 -0.032 0.074 0.163 14.0 -0.214 56.0 70.0 KIFC3 -0.017 0.077 0.177 14.0 -0.212 55.0 69.0 NCK1 0.024 0.02 -9999.0 0.0 -0.424 1.0 1.0 EXOC3 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.019 0.079 0.177 17.0 -0.209 56.0 73.0 NCK1/GIT1 0.037 0.016 -9999.0 0.0 -0.301 1.0 1.0 mol:GDP 0.024 0.085 -9999.0 0.0 -0.215 55.0 55.0 EXOC4 0.02 0.011 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.015 0.078 0.177 18.0 -0.208 55.0 73.0 PIP5K1C -0.014 0.077 0.177 18.0 -0.208 53.0 71.0 LIMA1 0.018 0.056 -9999.0 0.0 -0.424 8.0 8.0 ABI1 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.021 0.08 0.391 6.0 -9999.0 0.0 6.0 adherens junction assembly -0.011 0.088 0.273 10.0 -0.378 6.0 16.0 IGF-1R heterotetramer/IGF1 0.014 0.089 -9999.0 0.0 -0.216 62.0 62.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.029 0.026 -9999.0 0.0 -0.301 2.0 2.0 MET -0.045 0.135 -9999.0 0.0 -0.248 121.0 121.0 PLEKHA7 -0.019 0.083 0.178 14.0 -0.224 56.0 70.0 mol:GTP 0.052 0.033 -9999.0 0.0 -0.255 2.0 2.0 establishment of epithelial cell apical/basal polarity 0.019 0.116 0.326 26.0 -0.362 1.0 27.0 cortical actin cytoskeleton stabilization -0.01 0.083 -9999.0 0.0 -0.224 62.0 62.0 regulation of cell-cell adhesion -0.029 0.074 0.165 19.0 -0.211 50.0 69.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.01 0.084 -9999.0 0.0 -0.225 62.0 62.0