Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.072 0.14 -9999.0 0.0 -0.246 9.0 9.0 epithelial cell differentiation -0.051 0.135 -9999.0 0.0 -0.224 9.0 9.0 CYFIP2 0.027 0.032 -9999.0 0.0 -0.133 1.0 1.0 ENAH -0.059 0.084 -9999.0 0.0 -0.383 1.0 1.0 EGFR -0.007 0.116 -9999.0 0.0 -0.313 3.0 3.0 EPHA2 0.023 0.033 -9999.0 0.0 -0.133 1.0 1.0 MYO6 -0.072 0.139 -9999.0 0.0 -0.235 9.0 9.0 CTNNB1 0.001 0.114 -9999.0 0.0 -0.402 2.0 2.0 ABI1/Sra1/Nap1 0.054 0.035 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.048 0.11 -9999.0 0.0 -0.364 1.0 1.0 CTNND1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.056 0.106 0.183 1.0 -0.194 9.0 10.0 regulation of calcium-dependent cell-cell adhesion -0.065 0.116 -9999.0 0.0 -0.21 9.0 9.0 EGF 0.019 0.044 -9999.0 0.0 -0.133 2.0 2.0 NCKAP1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.056 0.132 -9999.0 0.0 -0.406 2.0 2.0 cortical microtubule organization -0.051 0.135 -9999.0 0.0 -0.224 9.0 9.0 GO:0000145 -0.065 0.093 0.169 1.0 -0.186 9.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.049 0.139 -9999.0 0.0 -0.226 9.0 9.0 MLLT4 0.016 0.082 -9999.0 0.0 -0.402 1.0 1.0 ARF6/GDP -0.072 0.096 -9999.0 0.0 -0.286 2.0 2.0 ARF6 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.061 0.049 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.062 0.099 -9999.0 0.0 -0.279 2.0 2.0 PVRL2 0.012 0.082 -9999.0 0.0 -0.402 1.0 1.0 ZYX -0.059 0.121 -9999.0 0.0 -0.216 9.0 9.0 ARF6/GTP 0.077 0.038 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.132 0.187 -9999.0 0.0 -0.287 14.0 14.0 EGFR/EGFR/EGF/EGF -0.074 0.126 -9999.0 0.0 -0.213 11.0 11.0 RhoA/GDP -0.052 0.15 -9999.0 0.0 -0.231 9.0 9.0 actin cytoskeleton organization -0.073 0.133 -9999.0 0.0 -0.23 9.0 9.0 IGF-1R heterotetramer 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.018 0.082 -9999.0 0.0 -0.402 1.0 1.0 DIAPH1 0.02 0.152 -9999.0 0.0 -0.543 1.0 1.0 Wnt receptor signaling pathway 0.051 0.135 0.224 9.0 -9999.0 0.0 9.0 RHOA 0.016 0.082 -9999.0 0.0 -0.402 1.0 1.0 RhoA/GTP -0.077 0.116 -9999.0 0.0 -0.529 1.0 1.0 CTNNA1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.075 0.136 -9999.0 0.0 -0.235 9.0 9.0 EFNA1 0.028 0.032 -9999.0 0.0 -0.133 1.0 1.0 LPP -0.062 0.099 0.177 1.0 -0.189 9.0 10.0 Ephrin A1/EPHA2 -0.056 0.125 -9999.0 0.0 -0.223 7.0 7.0 SEC6/SEC8 -0.074 0.125 -9999.0 0.0 -0.313 3.0 3.0 MGAT3 -0.065 0.118 -9999.0 0.0 -0.213 9.0 9.0 HGF/MET -0.056 0.126 -9999.0 0.0 -0.215 9.0 9.0 HGF 0.012 0.052 -9999.0 0.0 -0.133 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.073 0.141 -9999.0 0.0 -0.248 9.0 9.0 actin cable formation -0.035 0.08 -9999.0 0.0 -0.254 1.0 1.0 KIAA1543 -0.079 0.095 -9999.0 0.0 -0.204 9.0 9.0 KIFC3 -0.065 0.119 0.185 1.0 -0.216 9.0 10.0 NCK1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.068 0.118 -9999.0 0.0 -0.216 9.0 9.0 NCK1/GIT1 0.049 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.051 0.135 -9999.0 0.0 -0.224 9.0 9.0 EXOC4 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.065 0.119 -9999.0 0.0 -0.216 9.0 9.0 PIP5K1C -0.057 0.107 0.185 1.0 -0.197 9.0 10.0 LIMA1 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.067 0.104 -9999.0 0.0 -0.457 1.0 1.0 adherens junction assembly -0.042 0.113 0.292 1.0 -9999.0 0.0 1.0 IGF-1R heterotetramer/IGF1 -0.055 0.145 -9999.0 0.0 -0.229 9.0 9.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.013 0.087 -9999.0 0.0 -0.283 2.0 2.0 MET 0.024 0.033 -9999.0 0.0 -0.133 1.0 1.0 PLEKHA7 -0.071 0.109 -9999.0 0.0 -0.213 9.0 9.0 mol:GTP 0.059 0.048 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.043 0.154 0.286 1.0 -0.487 1.0 2.0 cortical actin cytoskeleton stabilization -0.072 0.14 -9999.0 0.0 -0.246 9.0 9.0 regulation of cell-cell adhesion -0.073 0.133 -9999.0 0.0 -0.23 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.073 0.141 -9999.0 0.0 -0.248 9.0 9.0