Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	6.0	314.0	51.0	-0.775	0.035	1000.0	-1000.0	-0.065	-1000.0
E-cadherin signaling events	6.0	34.0	5.0	-0.132	0.034	1000.0	-1000.0	0.016	-1000.0
Ephrin A  reverse signaling	5.0	37.0	7.0	-0.104	0.002	1000.0	-1000.0	-0.0	-1000.0
Thromboxane A2 receptor signaling	4.0	455.0	105.0	-0.246	0.05	1000.0	-1000.0	-0.032	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	4.0	300.0	68.0	-0.51	0.323	1000.0	-1000.0	-0.063	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	327.0	74.0	-0.132	0.077	1000.0	-1000.0	-0.038	-1000.0
TCGA08_retinoblastoma	4.0	39.0	8.0	-0.049	0.072	1000.0	-1000.0	-0.004	-1000.0
IL23-mediated signaling events	4.0	285.0	60.0	-0.666	0.036	1000.0	-1000.0	-0.081	-1000.0
IL12-mediated signaling events	3.0	315.0	87.0	-0.409	0.059	1000.0	-1000.0	-0.038	-1000.0
PLK2 and PLK4 events	3.0	11.0	3.0	-0.038	-1000.0	1000.0	-1000.0	0.002	-1000.0
Signaling events mediated by the Hedgehog family	3.0	161.0	52.0	-0.136	0.064	1000.0	-1000.0	-0.026	-1000.0
Ephrin B reverse signaling	3.0	154.0	48.0	-0.111	0.046	1000.0	-1000.0	-0.022	-1000.0
Endothelins	3.0	354.0	96.0	-0.333	0.046	1000.0	-1000.0	-0.038	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	274.0	76.0	-0.152	0.053	1000.0	-1000.0	-0.047	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	303.0	136.0	-0.423	0.086	1000.0	-1000.0	-0.037	-1000.0
Syndecan-1-mediated signaling events	2.0	71.0	34.0	-0.177	0.034	1000.0	-1000.0	-0.024	-1000.0
Visual signal transduction: Cones	2.0	85.0	38.0	-0.063	0.04	1000.0	-1000.0	-0.0	-1000.0
Osteopontin-mediated events	2.0	96.0	38.0	-0.103	0.034	1000.0	-1000.0	-0.021	-1000.0
HIF-1-alpha transcription factor network	2.0	198.0	76.0	-0.211	0.063	1000.0	-1000.0	-0.03	-1000.0
Arf6 signaling events	2.0	129.0	62.0	-0.054	0.068	1000.0	-1000.0	-0.011	-1000.0
PLK1 signaling events	2.0	226.0	85.0	-0.133	0.05	1000.0	-1000.0	-0.019	-1000.0
PDGFR-alpha signaling pathway	2.0	95.0	44.0	-0.236	0.042	1000.0	-1000.0	-0.019	-1000.0
Signaling events regulated by Ret tyrosine kinase	2.0	186.0	82.0	-0.059	0.052	1000.0	-1000.0	-0.04	-1000.0
Syndecan-3-mediated signaling events	2.0	81.0	35.0	-0.091	0.082	1000.0	-1000.0	-0.018	-1000.0
Calcium signaling in the CD4+ TCR pathway	2.0	64.0	31.0	-0.104	0.045	1000.0	-1000.0	-0.029	-1000.0
Nongenotropic Androgen signaling	2.0	132.0	52.0	-0.207	0.1	1000.0	-1000.0	-0.015	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	323.0	125.0	-0.091	0.081	1000.0	-1000.0	-0.034	-1000.0
Wnt signaling	2.0	14.0	7.0	-0.023	0.033	1000.0	-1000.0	-0.003	-1000.0
IL6-mediated signaling events	2.0	152.0	75.0	-0.151	0.055	1000.0	-1000.0	-0.049	-1000.0
BCR signaling pathway	2.0	215.0	99.0	-0.104	0.051	1000.0	-1000.0	-0.047	-1000.0
Syndecan-4-mediated signaling events	2.0	166.0	67.0	-0.099	0.045	1000.0	-1000.0	-0.027	-1000.0
E-cadherin signaling in keratinocytes	2.0	120.0	43.0	-0.131	0.038	1000.0	-1000.0	-0.019	-1000.0
Aurora B signaling	2.0	160.0	67.0	-0.172	0.052	1000.0	-1000.0	-0.029	-1000.0
ErbB2/ErbB3 signaling events	1.0	72.0	65.0	-0.072	0.049	1000.0	-1000.0	-0.061	-1000.0
Caspase cascade in apoptosis	1.0	122.0	74.0	-0.062	0.036	1000.0	-1000.0	-0.031	-1000.0
Coregulation of Androgen receptor activity	1.0	101.0	76.0	-0.081	0.06	1000.0	-1000.0	-0.028	-1000.0
ErbB4 signaling events	1.0	86.0	69.0	-0.114	0.051	1000.0	-1000.0	-0.025	-1000.0
Noncanonical Wnt signaling pathway	1.0	51.0	26.0	-0.027	0.033	1000.0	-1000.0	-0.023	-1000.0
Syndecan-2-mediated signaling events	1.0	89.0	69.0	-0.063	0.049	1000.0	-1000.0	-0.023	-1000.0
Cellular roles of Anthrax toxin	1.0	60.0	39.0	-0.176	0.034	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by PTP1B	1.0	81.0	76.0	-0.036	0.055	1000.0	-1000.0	-0.043	-1000.0
Presenilin action in Notch and Wnt signaling	1.0	84.0	61.0	-0.171	0.083	1000.0	-1000.0	-0.035	-1000.0
Aurora A signaling	1.0	63.0	60.0	-0.087	0.081	1000.0	-1000.0	-0.008	-1000.0
p75(NTR)-mediated signaling	1.0	162.0	125.0	-0.177	0.082	1000.0	-1000.0	-0.025	-1000.0
IL4-mediated signaling events	1.0	146.0	91.0	-0.518	0.27	1000.0	-1000.0	-0.087	-1000.0
BMP receptor signaling	1.0	133.0	81.0	-0.064	0.067	1000.0	-1000.0	-0.027	-1000.0
EPO signaling pathway	1.0	69.0	55.0	-0.0	0.09	1000.0	-1000.0	-0.022	-1000.0
Fc-epsilon receptor I signaling in mast cells	1.0	155.0	97.0	-0.104	0.057	1000.0	-1000.0	-0.065	-1000.0
amb2 Integrin signaling	1.0	116.0	82.0	-0.076	0.05	1000.0	-1000.0	-0.015	-1000.0
Nectin adhesion pathway	1.0	85.0	63.0	-0.132	0.068	1000.0	-1000.0	-0.047	-1000.0
Glucocorticoid receptor regulatory network	1.0	145.0	114.0	-0.274	0.075	1000.0	-1000.0	-0.046	-1000.0
Ceramide signaling pathway	1.0	103.0	76.0	-0.054	0.054	1000.0	-1000.0	-0.028	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	49.0	37.0	-0.091	0.059	1000.0	-1000.0	-0.014	-1000.0
Signaling events mediated by HDAC Class III	1.0	47.0	40.0	-0.133	0.093	1000.0	-1000.0	-0.033	-1000.0
TRAIL signaling pathway	1.0	57.0	48.0	-0.004	0.061	1000.0	-1000.0	-0.02	-1000.0
IL1-mediated signaling events	1.0	122.0	62.0	-0.102	0.057	1000.0	-1000.0	-0.022	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	62.0	52.0	-0.249	0.103	1000.0	-1000.0	-0.032	-1000.0
S1P1 pathway	1.0	54.0	36.0	-0.097	0.034	1000.0	-1000.0	-0.037	-1000.0
TCGA08_p53	1.0	9.0	7.0	-0.042	0.033	1000.0	-1000.0	-0.008	-1000.0
FAS signaling pathway (CD95)	1.0	58.0	47.0	-0.042	0.048	1000.0	-1000.0	-0.039	-1000.0
Signaling mediated by p38-alpha and p38-beta	1.0	77.0	44.0	-0.063	0.033	1000.0	-1000.0	-0.023	-1000.0
Integrins in angiogenesis	1.0	126.0	84.0	-0.079	0.081	1000.0	-1000.0	-0.029	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	52.0	45.0	-0.03	0.061	1000.0	-1000.0	-0.034	-1000.0
Canonical Wnt signaling pathway	1.0	70.0	51.0	-0.171	0.079	1000.0	-1000.0	-0.032	-1000.0
EPHB forward signaling	1.0	136.0	85.0	-0.058	0.077	1000.0	-1000.0	-0.039	-1000.0
Effects of Botulinum toxin	1.0	33.0	26.0	-0.148	0.055	1000.0	-1000.0	-0.002	-1000.0
TCGA08_rtk_signaling	1.0	26.0	26.0	-0.053	0.069	1000.0	-1000.0	-0.006	-1000.0
LPA receptor mediated events	1.0	114.0	102.0	-0.157	0.049	1000.0	-1000.0	-0.08	-1000.0
Class I PI3K signaling events	1.0	84.0	73.0	-0.059	0.067	1000.0	-1000.0	-0.021	-1000.0
EGFR-dependent Endothelin signaling events	1.0	34.0	21.0	-0.028	0.06	1000.0	-1000.0	-0.03	-1000.0
Angiopoietin receptor Tie2-mediated signaling	1.0	127.0	88.0	-0.142	0.045	1000.0	-1000.0	-0.056	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	1.0	130.0	120.0	-0.15	0.099	1000.0	-1000.0	-0.039	-1000.0
Visual signal transduction: Rods	1.0	98.0	52.0	-0.063	0.044	1000.0	-1000.0	-0.008	-1000.0
Signaling events mediated by PRL	1.0	64.0	34.0	-0.154	0.045	1000.0	-1000.0	-0.023	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	1.0	124.0	78.0	-0.078	0.047	1000.0	-1000.0	-0.041	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	27.0	17.0	-0.034	0.036	1000.0	-1000.0	-0.021	-1000.0
LPA4-mediated signaling events	0.0	7.0	12.0	-0.048	0.01	1000.0	-1000.0	-0.009	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	4.0	23.0	-0.002	0.062	1000.0	-1000.0	-0.015	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	0.0	5.0	34.0	-0.044	0.083	1000.0	-1000.0	-0.024	-1000.0
Canonical NF-kappaB pathway	0.0	16.0	39.0	-0.03	0.078	1000.0	-1000.0	-0.014	-1000.0
Signaling events mediated by HDAC Class II	0.0	29.0	75.0	-0.047	0.086	1000.0	-1000.0	-0.011	-1000.0
BARD1 signaling events	0.0	52.0	57.0	-0.055	0.068	1000.0	-1000.0	-0.034	-1000.0
Sphingosine 1-phosphate (S1P) pathway	0.0	27.0	28.0	-0.037	0.045	1000.0	-1000.0	-0.012	-1000.0
Circadian rhythm pathway	0.0	17.0	22.0	-0.073	0.058	1000.0	-1000.0	-0.032	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	0.0	41.0	54.0	-0.02	0.085	1000.0	-1000.0	-0.02	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	6.0	17.0	0.0	0.066	1000.0	-1000.0	-0.014	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	4.0	5.0	0.011	0.034	1000.0	-1000.0	0.017	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	0.0	79.0	85.0	-0.25	0.074	1000.0	-1000.0	-0.033	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	44.0	65.0	-0.041	0.072	1000.0	-1000.0	-0.041	-1000.0
Arf6 downstream pathway	0.0	8.0	43.0	-0.051	0.07	1000.0	-1000.0	-0.028	-1000.0
Aurora C signaling	0.0	3.0	7.0	-0.0	0.042	1000.0	-1000.0	-0.004	-1000.0
FOXA2 and FOXA3 transcription factor networks	0.0	17.0	46.0	-0.032	0.061	1000.0	-1000.0	-0.066	-1000.0
Glypican 1 network	0.0	41.0	48.0	-0.039	0.062	1000.0	-1000.0	-0.019	-1000.0
Insulin-mediated glucose transport	0.0	9.0	32.0	-0.0	0.07	1000.0	-1000.0	-0.01	-1000.0
mTOR signaling pathway	0.0	22.0	53.0	-0.026	0.069	1000.0	-1000.0	-0.03	-1000.0
IFN-gamma pathway	0.0	45.0	68.0	-0.041	0.058	1000.0	-1000.0	-0.04	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	16.0	68.0	-0.052	0.068	1000.0	-1000.0	-0.022	-1000.0
Reelin signaling pathway	0.0	28.0	56.0	-0.048	0.087	1000.0	-1000.0	-0.013	-1000.0
S1P5 pathway	0.0	2.0	17.0	-0.008	0.034	1000.0	-1000.0	-0.005	-1000.0
ceramide signaling pathway	0.0	34.0	49.0	-0.03	0.049	1000.0	-1000.0	-0.028	-1000.0
HIF-2-alpha transcription factor network	0.0	27.0	43.0	-0.115	0.117	1000.0	-1000.0	-0.046	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	46.0	83.0	-0.023	0.067	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by HDAC Class I	0.0	39.0	104.0	-0.064	0.072	1000.0	-1000.0	-0.031	-1000.0
FoxO family signaling	0.0	23.0	64.0	-0.086	0.063	1000.0	-1000.0	-0.037	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	12.0	15.0	-0.054	0.033	1000.0	-1000.0	-0.01	-1000.0
Retinoic acid receptors-mediated signaling	0.0	21.0	58.0	-0.039	0.067	1000.0	-1000.0	-0.035	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	29.0	36.0	-0.091	0.065	1000.0	-1000.0	-0.029	-1000.0
Atypical NF-kappaB pathway	0.0	13.0	31.0	-0.01	0.047	1000.0	-1000.0	-0.009	-1000.0
IL2 signaling events mediated by PI3K	0.0	20.0	58.0	-0.015	0.06	1000.0	-1000.0	-0.039	-1000.0
TCR signaling in naïve CD8+ T cells	0.0	85.0	93.0	-0.108	0.126	1000.0	-1000.0	-0.038	-1000.0
Regulation of p38-alpha and p38-beta	0.0	42.0	54.0	-0.036	0.079	1000.0	-1000.0	-0.043	-1000.0
Glypican 2 network	0.0	2.0	4.0	-0.0	0.015	1000.0	-1000.0	-0.0	-1000.0
IL27-mediated signaling events	0.0	38.0	51.0	-0.097	0.068	1000.0	-1000.0	-0.042	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.0	0.082	1000.0	-1000.0	-0.02	-1000.0
IL2 signaling events mediated by STAT5	0.0	20.0	22.0	-0.075	0.044	1000.0	-1000.0	-0.029	-1000.0
Arf6 trafficking events	0.0	18.0	71.0	-0.049	0.064	1000.0	-1000.0	-0.024	-1000.0
Regulation of Telomerase	0.0	89.0	102.0	-0.125	0.088	1000.0	-1000.0	-0.025	-1000.0
IGF1 pathway	0.0	15.0	57.0	-0.036	0.09	1000.0	-1000.0	-0.024	-1000.0
Insulin Pathway	0.0	42.0	74.0	-0.04	0.082	1000.0	-1000.0	-0.021	-1000.0
Plasma membrane estrogen receptor signaling	0.0	52.0	86.0	-0.034	0.053	1000.0	-1000.0	-0.046	-1000.0
VEGFR1 specific signals	0.0	15.0	56.0	-0.017	0.073	1000.0	-1000.0	-0.023	-1000.0
S1P3 pathway	0.0	16.0	42.0	-0.038	0.05	1000.0	-1000.0	-0.034	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	16.0	33.0	-0.051	0.088	1000.0	-1000.0	-0.033	-1000.0
Rapid glucocorticoid signaling	0.0	19.0	20.0	-0.092	0.029	1000.0	-1000.0	-0.001	-1000.0
PDGFR-beta signaling pathway	0.0	66.0	97.0	-0.036	0.095	1000.0	-1000.0	-0.028	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.032	0.032	1000.0	-1000.0	-0.019	-1000.0
S1P4 pathway	0.0	4.0	25.0	-0.0	0.045	1000.0	-1000.0	-0.013	-1000.0
p38 MAPK signaling pathway	0.0	37.0	44.0	-0.039	0.061	1000.0	-1000.0	-0.014	-1000.0
Arf1 pathway	0.0	3.0	54.0	-0.001	0.046	1000.0	-1000.0	-0.011	-1000.0
Alternative NF-kappaB pathway	0.0	5.0	13.0	-0.0	0.067	1000.0	-1000.0	-0.0	-1000.0
Regulation of Androgen receptor activity	0.0	54.0	70.0	-0.181	0.058	1000.0	-1000.0	-0.041	-1000.0
Total	136	11006	7203	-13.4870053971	-991.748933873	131000	-131000	-3.54379822854	-131000