Clinical Features	CN_CNMF		METHLYATION_CNMF		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
TP53	65 (32%)	137	0.058009	1	0.45061	1	0.00025	0.2	0.97913	1	0.0089799	1	9.9999e-06	0.00806	0.02964	1	0.00238	1
CTNNB1	57 (28%)	145	0.00228	1	0.00017	0.136	9.9999e-06	0.00806	9.9999e-06	0.00806	0.2184	1	9.9999e-06	0.00806	0.00058999	0.471	9.9999e-06	0.00806
ARID1A	25 (12%)	177	0.72904	1	0.89128	1	0.19127	1	0.40988	1	0.35315	1	0.02135	1	0.45175	1	0.51109	1
RB1	18 (9%)	184	0.02168	1	0.00224	1	0.03938	1	0.03395	1	0.34042	1	0.52212	1	0.086489	1	0.31084	1
AXIN1	12 (6%)	190	0.066989	1	0.69219	1	0.13198	1	0.066879	1	0.1438	1	0.04752	1	0.01164	1	0.076449	1
KRTAP5-11	5 (2%)	197	0.53439	1	0.85922	1	0.48856	1	0.84299	1	0.45125	1	0.88448	1	0.6568	1	0.7909	1
AHCTF1	13 (6%)	189	0.87489	1	0.61389	1	0.77033	1	0.32905	1	0.57806	1	0.10242	1	0.77923	1	0.55821	1
GPATCH4	11 (5%)	191	0.04047	1	0.85501	1	0.5853	1	0.63497	1	0.17709	1	0.12161	1	0.04364	1	0.061729	1
CD207	8 (4%)	194	0.30486	1	0.18547	1	0.43224	1	0.69136	1	0.52912	1	0.56765	1	0.82001	1	0.55663	1
EEF1A1	9 (4%)	193	1	1	0.3768	1	0.17292	1	0.02561	1	0.75418	1	0.58888	1	0.55145	1	0.6064	1
BAP1	11 (5%)	191	0.73158	1	0.00168	1	5e-05	0.04	0.00094999	0.757	0.02124	1	0.00098999	0.788	0.00323	1	0.03316	1
CHIT1	8 (4%)	194	0.41985	1	1	1	0.72106	1	0.71518	1	0.4679	1	0.41781	1	0.50268	1	0.85049	1
PPIAL4G	7 (3%)	195	0.79434	1	0.32437	1	0.28308	1	0.26851	1	0.22778	1	0.12347	1	0.16497	1	0.1106	1
ALB	24 (12%)	178	0.03625	1	0.41357	1	0.62057	1	0.63051	1	0.88064	1	0.90685	1	0.32706	1	0.63795	1
PABPC1	8 (4%)	194	0.27429	1	1	1	0.32179	1	0.45934	1	0.66791	1	0.84128	1	0.93298	1	0.97851	1
TREML2	6 (3%)	196	0.62784	1	1	1	0.17462	1	0.090609	1	0.4494	1	0.03163	1	0.49159	1	0.03242	1
PRH2	6 (3%)	196	0.66069	1	0.87447	1	0.44771	1	0.8658	1	0.76922	1	0.85912	1	0.39004	1	0.97149	1
MUC17	28 (14%)	174	0.8648	1	0.87019	1	0.66288	1	0.73398	1	0.63469	1	0.55154	1	0.83977	1	0.50206	1
AZIN1	13 (6%)	189	0.31823	1	0.43961	1	0.03747	1	0.38777	1	0.02762	1	0.01523	1	0.10756	1	0.0050099	1
NBPF3	7 (3%)	195	0.26707	1	0.42634	1	0.03532	1	0.86396	1	0.79564	1	0.58731	1	0.54163	1	0.82466	1
BCLAF1	14 (7%)	188	0.82855	1	0.29079	1	0.67864	1	1	1	0.88308	1	0.82348	1	0.53502	1	0.90754	1
SCRN3	9 (4%)	193	0.3464	1	0.19914	1	0.73077	1	0.49267	1	0.6884	1	0.58905	1	0.33017	1	0.60974	1
MUC6	25 (12%)	177	0.12021	1	0.085419	1	0.53187	1	0.92288	1	0.58843	1	0.23408	1	0.43638	1	0.30719	1
UGT2B28	11 (5%)	191	0.30181	1	0.22472	1	0.14041	1	0.13048	1	0.14566	1	0.14246	1	0.69346	1	0.29284	1
CDHR5	11 (5%)	191	0.055049	1	0.11134	1	0.95972	1	0.66411	1	0.78922	1	0.80508	1	0.83882	1	0.89014	1
KCTD3	6 (3%)	196	0.02402	1	0.37566	1	0.75539	1	0.65724	1	0.50844	1	0.38264	1	0.34844	1	0.30919	1
CDC27	14 (7%)	188	0.53433	1	0.29099	1	0.053959	1	0.00473	1	0.11438	1	0.01961	1	0.11874	1	0.057739	1
CR1	19 (9%)	183	0.95399	1	0.86098	1	0.50782	1	0.44187	1	0.29569	1	0.31626	1	0.54716	1	0.75759	1
TCEAL6	4 (2%)	198	0.03834	1	0.15425	1	0.062249	1	0.78577	1	0.55271	1	0.27433	1	1	1	0.37997	1
LILRA6	11 (5%)	191	0.23177	1	0.20751	1	0.35049	1	0.078089	1	0.11702	1	0.0060499	1	0.16189	1	0.03744	1
BIK	3 (1%)	199	0.35087	1	0.79535	1	0.71608	1	1	1	0.25295	1	0.1077	1	0.22566	1	0.03001	1
SRRM3	4 (2%)	198	0.03845	1	0.15463	1	0.13233	1	0.31488	1	0.085009	1	0.0222	1	0.86796	1	0.03009	1
MKI67	17 (8%)	185	1	1	0.4664	1	0.55332	1	0.4307	1	0.94833	1	0.3488	1	0.16809	1	0.66646	1
ALDH3B1	5 (2%)	197	0.01175	1	0.074029	1	0.34533	1	1	1	0.74084	1	0.40668	1	1	1	0.53795	1
POTEG	13 (6%)	189	0.093089	1	0.47244	1	0.83416	1	0.41916	1	0.6165	1	0.32681	1	0.14813	1	0.33671	1
ZNF658	8 (4%)	194	0.01143	1	0.23751	1	0.43697	1	0.23254	1	1	1	0.1416	1	0.79977	1	0.30216	1
TCHH	22 (11%)	180	0.514	1	0.04243	1	0.65835	1	0.6077	1	1	1	0.10585	1	0.84378	1	0.32289	1
TMEM176A	4 (2%)	198	0.17379	1	0.15362	1	0.23923	1	1	1	0.13375	1	0.68193	1	0.25681	1	0.93475	1
RP1L1	21 (10%)	181	0.34071	1	0.061029	1	0.01089	1	0.54384	1	0.67037	1	0.79925	1	0.32855	1	0.3013	1
TSC2	15 (7%)	187	0.31646	1	0.04516	1	0.47171	1	0.49927	1	0.83665	1	0.57845	1	0.60371	1	0.73989	1
PRKDC	24 (12%)	178	0.88668	1	0.16393	1	0.62456	1	0.91758	1	1	1	0.16963	1	0.68868	1	0.36653	1
NRD1	11 (5%)	191	0.42165	1	0.92391	1	0.88666	1	0.17731	1	0.79087	1	0.14435	1	0.56309	1	0.080439	1
TAS2R20	4 (2%)	198	0.30126	1	0.27822	1	0.48722	1	0.01062	1	0.83592	1	0.082939	1	0.66676	1	0.53881	1
PTEN	10 (5%)	192	0.18839	1	0.098229	1	0.8596	1	0.82352	1	0.45977	1	0.82877	1	0.93401	1	0.81046	1
CYFIP2	13 (6%)	189	0.76592	1	0.7138	1	0.65659	1	0.33129	1	0.18562	1	0.88655	1	0.31122	1	0.60615	1
PRAMEF1	9 (4%)	193	1	1	0.50729	1	0.28469	1	0.14478	1	0.57866	1	0.02063	1	0.064239	1	0.20272	1
MST1	8 (4%)	194	0.42056	1	0.58391	1	0.63643	1	0.77715	1	0.81879	1	0.65211	1	0.96508	1	0.94577	1
ZC3H7A	12 (6%)	190	0.2585	1	0.74404	1	0.71023	1	0.85589	1	0.24294	1	0.79248	1	0.25249	1	0.12839	1
MLL3	30 (15%)	172	0.43795	1	0.49445	1	0.01768	1	0.48111	1	0.9067	1	0.56428	1	0.14917	1	0.92496	1
HNRNPCL1	11 (5%)	191	0.16197	1	0.925	1	0.54572	1	0.76089	1	0.19337	1	0.32737	1	0.73161	1	0.84765	1
TUBA3E	7 (3%)	195	0.79466	1	0.88867	1	0.12201	1	0.065809	1	0.69843	1	0.0074699	1	0.21903	1	0.11507	1
MUC21	16 (8%)	186	0.66047	1	1	1	0.87485	1	0.43871	1	0.94505	1	0.73396	1	0.61046	1	0.66217	1
HPS4	5 (2%)	197	0.17518	1	0.056599	1	0.26065	1	0.10524	1	0.45087	1	0.23918	1	0.92861	1	0.88513	1
OR2T4	14 (7%)	188	0.01616	1	0.054599	1	0.053229	1	0.0128	1	0.60775	1	0.21495	1	0.62421	1	0.16688	1
SPDYE1	4 (2%)	198	0.23495	1	0.36739	1	0.4908	1	0.14392	1	0.45273	1	0.04255	1	0.72703	1	0.45356	1
COG2	6 (3%)	196	0.28904	1	0.11791	1	0.55067	1	0.84399	1	0.074209	1	0.30169	1	0.52331	1	0.35679	1
SEC63	10 (5%)	192	0.053479	1	0.088589	1	0.21944	1	0.71311	1	0.54995	1	0.15976	1	0.90608	1	0.93412	1
LILRA3	5 (2%)	197	0.23442	1	0.21339	1	0.02263	1	0.00464	1	0.45193	1	0.0089899	1	0.13949	1	0.18909	1
CYP2A6	6 (3%)	196	1	1	0.17235	1	0.838	1	0.074079	1	1	1	0.67823	1	0.56163	1	0.51152	1
ZC3H11A	6 (3%)	196	0.37281	1	0.3244	1	0.21613	1	0.29603	1	0.88262	1	0.23929	1	0.8615	1	0.18601	1
LCE4A	10 (5%)	192	0.22237	1	0.54904	1	0.45286	1	1	1	0.84429	1	0.67245	1	0.052119	1	0.93445	1
ATXN3	6 (3%)	196	0.13844	1	0.32978	1	0.87257	1	0.86607	1	0.44533	1	0.88685	1	0.20522	1	0.83653	1
GTF2IRD2B	5 (2%)	197	0.064789	1	0.072799	1	0.13257	1	0.31474	1	0.29628	1	0.11317	1	0.96225	1	0.15925	1
QRICH2	19 (9%)	183	0.29532	1	0.35239	1	0.19926	1	0.21442	1	0.53212	1	0.17345	1	0.1112	1	0.46465	1
PLAU	6 (3%)	196	0.50725	1	0.66487	1	0.30979	1	1	1	0.8815	1	0.76445	1	0.8825	1	0.91497	1
MAPKAPK2	4 (2%)	198	0.45368	1	0.68915	1	0.80312	1	1	1	0.45449	1	0.76926	1	0.82975	1	0.14638	1
NAP1L1	6 (3%)	196	0.50463	1	1	1	0.13356	1	0.67238	1	0.339	1	0.85928	1	0.72827	1	0.55995	1
FAM118A	4 (2%)	198	0.68171	1	0.81701	1	0.53211	1	0.67461	1	0.36876	1	0.59879	1	0.2171	1	1	1
SLC7A6OS	4 (2%)	198	1	1	1	1	0.03752	1	0.41034	1	0.29056	1	0.72528	1	0.3889	1	0.57288	1
NBPF10	12 (6%)	190	0.20442	1	0.74519	1	1	1	1	1	0.5576	1	0.50464	1	0.52586	1	0.76424	1
ZXDC	6 (3%)	196	1	1	0.2051	1	0.23647	1	0.42227	1	0.0086199	1	0.03713	1	0.124	1	0.064719	1
TAS2R30	8 (4%)	194	1	1	0.89804	1	0.53615	1	0.89781	1	0.74166	1	1	1	0.15241	1	0.97846	1
KRTAP10-2	7 (3%)	195	0.38047	1	0.70158	1	0.3168	1	0.2695	1	0.89743	1	0.0013	1	0.10348	1	0.13886	1
PPA2	4 (2%)	198	0.68358	1	0.58089	1	0.80134	1	1	1	1	1	0.59971	1	0.28413	1	0.45413	1
SEPT2	7 (3%)	195	0.26462	1	0.2848	1	0.50284	1	0.29497	1	0.69804	1	0.58489	1	0.81612	1	0.46659	1
DRD3	5 (2%)	197	0.62694	1	0.072589	1	0.0385	1	0.53093	1	0.0070299	1	0.3137	1	0.1336	1	0.35608	1
PSRC1	4 (2%)	198	0.56176	1	0.36943	1	NA	NA	NA	NA	0.04182	1	0.68233	1	0.31934	1	0.93513	1
KRTAP10-9	3 (1%)	199	0.47163	1	0.61159	1	0.34899	1	0.091539	1	1	1	0.04322	1	0.43145	1	0.6293	1
SPATA12	6 (3%)	196	0.87829	1	1	1	0.85474	1	1	1	0.65802	1	0.85911	1	0.84514	1	0.68036	1
GPR112	15 (7%)	187	0.52817	1	0.45053	1	0.53336	1	0.47706	1	0.48762	1	0.39279	1	0.1623	1	0.18106	1
CLTCL1	16 (8%)	186	0.35508	1	0.37665	1	0.70907	1	0.59995	1	0.7446	1	0.084339	1	0.82564	1	0.29102	1
OR2A14	5 (2%)	197	0.6259	1	0.21525	1	0.80548	1	1	1	1	1	0.36308	1	0.58714	1	0.53559	1
OR4C16	7 (3%)	195	0.092459	1	0.12726	1	0.01972	1	0.03365	1	0.89572	1	0.00339	1	0.75586	1	0.078839	1
GBP1	8 (4%)	194	0.27652	1	0.7297	1	0.84208	1	0.36864	1	0.74335	1	0.47744	1	0.83243	1	0.61015	1
OR6B3	5 (2%)	197	0.73634	1	0.85902	1	0.76664	1	0.4177	1	0.11638	1	0.20536	1	0.78054	1	0.076349	1
OR2T27	10 (5%)	192	0.77334	1	0.01094	1	0.26452	1	0.54452	1	0.35448	1	0.16215	1	0.51158	1	0.23092	1
RAET1E	5 (2%)	197	0.84939	1	0.32342	1	0.18168	1	0.03323	1	0.74266	1	0.01868	1	0.55056	1	0.20352	1
SHROOM1	5 (2%)	197	0.62871	1	0.86111	1	1	1	1	1	1	1	0.25997	1	0.89942	1	0.077349	1
OR52I2	6 (3%)	196	0.76418	1	1	1	0.34361	1	0.16421	1	0.76849	1	0.04799	1	0.2951	1	0.33918	1
OR13C2	4 (2%)	198	0.17304	1	0.20251	1	0.084919	1	0.070629	1	0.4526	1	0.13628	1	0.66961	1	0.13789	1
LIPC	6 (3%)	196	0.87913	1	1	1	0.11945	1	0.74665	1	0.243	1	0.9694	1	0.33006	1	0.97194	1
FAM22F	4 (2%)	198	0.17267	1	0.01142	1	0.03424	1	0.04128	1	0.18045	1	0.82536	1	0.00101	0.803	0.30155	1
GLRX3	4 (2%)	198	0.29876	1	0.36759	1	0.11353	1	0.02131	1	0.45125	1	0.0079199	1	0.28551	1	0.20131	1
HOXA4	5 (2%)	197	0.85062	1	0.38757	1	0.9311	1	0.84363	1	0.29336	1	0.084679	1	0.39269	1	0.2062	1
DENND4B	9 (4%)	193	0.3834	1	0.19821	1	0.051919	1	0.21701	1	0.37508	1	0.2234	1	0.4758	1	0.37958	1
ESX1	6 (3%)	196	0.87858	1	0.66397	1	0.15725	1	0.19563	1	0.88078	1	0.25645	1	0.12842	1	0.13536	1
SLFN12L	6 (3%)	196	1	1	0.28172	1	0.43295	1	0.84312	1	0.88251	1	0.81287	1	0.45622	1	0.91627	1
FKBP4	5 (2%)	197	0.534	1	0.38427	1	0.34534	1	0.24717	1	0.84739	1	0.55402	1	0.27914	1	0.43058	1
AQP7	9 (4%)	193	0.91082	1	0.02258	1	0.1635	1	0.44877	1	0.16938	1	0.23283	1	0.60641	1	0.15243	1
MAP4K5	10 (5%)	192	0.38432	1	0.91864	1	0.54961	1	1	1	1	1	0.3729	1	0.60721	1	0.63395	1
BCL11A	7 (3%)	195	0.79512	1	0.48334	1	0.75462	1	0.073319	1	0.00489	1	0.18874	1	0.30256	1	0.13437	1