rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(2), ARF3(1), CCND1(1), CDKN1A(6), CDKN1B(2), CDKN2A(3), CFL1(3), E2F1(2), MDM2(2), PRB1(2), TP53(67)	2450400	91	77	77	10	14	8	7	33	29	0	0.00110	3.33e-15	2.05e-12
2	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	MYC(2), SP1(2), SP3(3), TP53(67), WT1(6)	2114891	80	74	66	7	12	11	8	25	24	0	0.000161	7.88e-15	2.43e-12
3	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(9), DNAJC3(3), EIF2S1(1), EIF2S2(1), MAP3K14(2), NFKB1(7), NFKBIA(2), RELA(4), TP53(67)	3064238	96	82	82	16	13	11	12	30	30	0	0.0112	4.97e-08	1.02e-05
4	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(15), CDC25A(2), CDC25B(4), CDC25C(1), CHEK1(7), MYT1(6), RB1(19), TP53(67), WEE1(4), YWHAH(1)	5295129	126	97	112	21	17	16	9	42	41	1	0.0156	3.39e-06	0.000522
5	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(12), DAXX(1), PAX3(6), PML(5), RARA(2), RB1(19), SIRT1(5), SP100(3), TNF(2), TNFRSF1A(2), TNFRSF1B(3), TP53(67)	5618548	127	95	113	21	16	25	12	35	38	1	0.00767	2.30e-05	0.00284
6	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	DNAJA3(1), IFNG(3), IFNGR1(5), IFNGR2(2), IKBKB(6), JAK2(9), LIN7A(1), NFKB1(7), NFKBIA(2), RB1(19), RELA(4), TNF(2), TNFRSF1A(2), TNFRSF1B(3), TP53(67), USH1C(5), WT1(6)	5765477	144	100	130	23	22	21	14	44	42	1	0.00331	9.36e-05	0.00961
7	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(10), ATM(15), BAX(1), BCL2(1), CCND1(1), CCNE1(2), CDKN1A(6), E2F1(2), GADD45A(1), MDM2(2), RB1(19), TP53(67)	5400786	127	92	113	22	16	13	9	47	41	1	0.0253	0.000169	0.0149
8	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(1), CDKN2A(3), E2F1(2), MDM2(2), MYC(2), PIK3CA(10), PIK3R1(5), POLR1A(10), POLR1B(3), POLR1C(1), POLR1D(1), RAC1(1), RB1(19), TBX2(4), TP53(67)	5956904	131	97	115	23	17	17	12	41	43	1	0.0216	0.000388	0.0299
9	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(15), ATR(14), CDC25C(1), CHEK1(7), CHEK2(6), TP53(67), YWHAH(1)	4722879	111	86	97	21	17	13	10	40	30	1	0.0306	0.00648	0.443
10	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(1), FOSB(1), GRIA2(10), JUND(2), PPP1R1B(2)	1119909	16	15	16	1	5	4	2	3	2	0	0.0446	0.00998	0.615
11	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(7)	210646	7	7	7	2	1	2	1	3	0	0	0.616	0.0204	1.000
12	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(4), NFYC(2), RB1(19), SP1(2), SP3(3)	2006384	30	28	30	9	3	3	1	6	16	1	0.801	0.0466	1.000
13	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(8), LPO(8), MPO(11), PRDX1(1), PRDX2(2), PRDX5(3), PRDX6(1), TPO(11), TYR(6)	2928607	51	43	51	9	11	8	9	15	8	0	0.0310	0.186	1.000
14	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(2), BCL2(1), EGFR(7), IGF1R(12), MYC(2), POLR2A(10), PPP2CA(4), PRKCA(2), RB1(19), TEP1(15), TERF1(5), TERT(3), TNKS(6), TP53(67), XRCC5(6)	8262464	161	104	147	29	26	26	11	50	47	1	0.0103	0.296	1.000
15	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(2)	151093	2	2	2	1	0	0	0	1	1	0	0.941	0.358	1.000
16	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(1), FOS(2), JUN(1), KEAP1(9), MAFG(1), MAPK1(3), MAPK14(4), NFE2L2(5), PRKCA(2)	2741845	28	25	28	3	5	5	4	9	5	0	0.0615	0.384	1.000
17	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(11), AKT1(2), ATM(15), BAX(1), CDKN1A(6), CPB2(3), CSNK1A1(1), FHL2(2), GADD45A(1), HIC1(1), HIF1A(3), IGFBP3(1), MDM2(2), NQO1(2), TP53(67)	6446606	118	90	103	24	14	12	12	48	32	0	0.0797	0.445	1.000
18	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(6)	501887	6	5	6	0	1	1	2	1	1	0	0.117	0.453	1.000
19	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(2), BCKDK(3), CBS(5), CTH(3), MUT(4)	1474395	17	14	17	2	3	4	0	3	7	0	0.202	0.486	1.000
20	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(4), GLS2(3), GLUD1(3), GLUD2(3)	1320815	13	13	13	2	1	6	3	1	2	0	0.212	0.565	1.000
21	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(3), PGLYRP2(1)	518233	4	4	4	1	0	2	0	1	1	0	0.753	0.610	1.000
22	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(8), GBA(1), LPO(8), MPO(11), PRDX6(1), TPO(11)	2527768	40	34	40	9	10	7	8	10	5	0	0.110	0.641	1.000
23	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(2), APAF1(10), ATM(15), BAX(1), BCL2(1), BID(2), CASP3(2), CASP6(2), CASP7(4), CASP9(1), EIF2S1(1), PRKCA(2), PTK2(9), PXN(5), STAT1(7), TLN1(12), TP53(67)	8141987	143	98	129	28	25	26	14	46	32	0	0.00920	0.719	1.000
24	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(3), ECHS1(2), EHHADH(14), HADHA(3), SDS(4)	1469142	26	17	26	7	5	4	5	9	3	0	0.292	0.759	1.000
25	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(5), ACTN2(8), ACTN3(1), BCAR1(3), CSK(2), CTNNA1(1), CTNNA2(10), CTNNB1(59), PECAM1(1), PTK2(9), PXN(5), SRC(2), VCL(4)	5813857	110	81	79	19	13	22	12	51	11	1	0.0214	0.774	1.000
26	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(1), TGDS(1), UGDH(4)	1212264	6	6	6	1	2	2	0	0	2	0	0.453	0.902	1.000
27	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(4), AOC2(3), AOC3(3), CES1(3), ESD(2)	1815413	15	15	15	3	1	4	4	5	1	0	0.206	0.903	1.000
28	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(2), PSMA2(1), PSMA4(3), PSMA5(1), PSMA6(1), PSMA7(4), PSMB1(2), PSMB10(2), PSMB2(1), PSMB3(1), PSMB5(3), PSMB6(1), PSMB7(2), PSMB8(4), PSMB9(1)	2625712	29	23	29	6	3	5	6	11	4	0	0.220	0.926	1.000
29	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(1), IFNG(3), IL12A(6), IL12B(2), IL16(7), IL18(2), IL1A(3), IL2(1), IL3(2), IL4(1), IL6(3), IL9(1), LTA(2), TNF(2)	2973045	36	29	36	9	5	3	8	15	5	0	0.233	0.938	1.000
30	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1)	451428	1	1	1	0	0	0	0	1	0	0	0.849	0.945	1.000
31	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(2), BCAR1(3), CDKN1B(2), ILK(1), ITGB1(3), MAPK1(3), MAPK3(1), PDK2(2), PDPK1(2), PIK3CA(10), PIK3R1(5), PTEN(11), PTK2(9), SHC1(5), SOS1(10)	5914059	69	49	68	11	13	15	10	17	12	2	0.0176	0.961	1.000
32	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(4), CS(1), FH(4), IDH2(5), MDH1(1), OGDH(4), SDHA(5), SUCLA2(3)	2847561	27	22	27	4	4	2	6	13	2	0	0.0966	0.966	1.000
33	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(10), EGFR(7), ERBB3(10), NRG1(7), UBE2D1(1)	3037157	35	33	35	9	3	12	3	10	7	0	0.292	0.974	1.000
34	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(4), IFNG(3), IL12A(6), IL12B(2), IL18(2), IL2(1)	925112	18	15	18	8	1	1	3	10	3	0	0.860	0.975	1.000
35	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(1), EPHX2(2), HSD3B7(2), RDH11(2), RDH12(2), RDH13(1)	1379127	10	10	10	3	4	0	1	4	1	0	0.615	0.976	1.000
36	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(2), PLCD1(1), PRKCA(2), TGM2(5)	1536505	10	9	10	2	7	2	0	1	0	0	0.415	0.977	1.000
37	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(1), TGDS(1), UGDH(4), UGP2(2)	1522119	8	8	8	2	2	2	0	1	3	0	0.603	0.980	1.000
38	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(1), CASP3(2), CASP8(3), CFL1(3), CFLAR(2)	1141167	11	11	11	7	5	1	0	2	3	0	0.960	0.981	1.000
39	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), CSF2(2), FLT3(10), IGF1(1), IL1A(3), IL3(2), IL6(3), IL9(1), KITLG(2), TGFB1(1), TGFB2(4), TGFB3(3)	2591230	33	29	33	8	6	9	9	5	4	0	0.153	0.988	1.000
40	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), NRF1(1), UBE2B(2), UBE2C(1), UBE2D1(1), UBE2D2(2), UBE2D3(2), UBE2E1(3), UBE2G1(1), UBE2G2(1), UBE2H(1), UBE2J1(4), UBE2J2(3), UBE2L3(1), UBE2L6(1), UBE2M(2), UBE2N(4), UBE2S(1), UBE3A(4)	3128959	36	32	36	8	8	7	5	8	8	0	0.181	0.989	1.000
41	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(2), RAB11A(1), RAB1A(3), RAB27A(2), RAB4A(2), RAB6A(2), RAB9A(1)	1291001	13	11	13	4	3	3	1	3	3	0	0.631	0.989	1.000
42	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(2), ESR1(4), GREB1(14), HSPB2(4), MTA1(2), PDZK1(2), TUBA8(4)	3407013	32	31	32	7	11	8	2	8	3	0	0.144	0.993	1.000
43	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(1), FUT1(2), FUT2(1), FUT3(3), FUT5(4), FUT6(3), ST3GAL3(4)	1514085	18	10	16	4	8	2	2	4	2	0	0.338	0.994	1.000
44	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(2), GNAS(9), GNB1(4), GNGT1(1), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(2)	2942258	27	25	25	6	8	6	1	7	4	1	0.414	0.994	1.000
45	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(2), CDC25B(4), CDK7(1), CDKN1A(6), CHEK1(7), NEK1(9), WEE1(4)	2287862	33	27	33	8	3	9	2	13	6	0	0.356	0.994	1.000
46	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), ATP6V0C(1), CAT(1), EPX(8), LPO(8), MPO(11), PRDX1(1), PRDX2(2), PRDX5(3), PRDX6(1), SHMT1(4), SHMT2(2), TPO(11)	3550798	54	42	54	13	13	9	8	12	12	0	0.168	0.995	1.000
47	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(6), ALDOB(3)	1174597	9	8	9	4	1	2	2	2	2	0	0.772	0.996	1.000
48	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), PTK2B(8), SHC1(5), SOS1(10), SRC(2)	2590480	26	23	26	6	5	6	3	5	6	1	0.351	0.996	1.000
49	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), FDPS(3), IDI1(2), SQLE(3)	1000310	9	9	9	5	2	0	2	3	2	0	0.859	0.996	1.000
50	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(1), SUCLA2(3)	642498	4	4	4	7	1	0	0	2	1	0	1.000	0.997	1.000
51	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), GSTZ1(2), HGD(2)	660988	5	5	5	3	2	0	0	2	1	0	0.917	0.997	1.000
52	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	9	BPNT1(2), PAPSS1(4), PAPSS2(5), SULT1A2(4), SULT1E1(1), SULT2A1(3), SUOX(4)	2548761	23	20	22	5	5	6	3	7	2	0	0.305	0.998	1.000
53	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(3), NDUFA1(1), SDHA(5), SDHB(3)	1956422	12	11	12	3	2	1	3	5	1	0	0.513	0.998	1.000
54	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(4), DCN(2), FMOD(2), KERA(2), LUM(2)	1073872	12	11	12	5	4	3	1	2	2	0	0.835	0.998	1.000
55	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(7), GNAS(9), GNB1(4), GNGT1(1), PRKACA(2)	1975095	23	21	21	5	6	4	2	9	2	0	0.412	0.998	1.000
56	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(3), COQ5(2), COQ6(4), COQ7(1), NDUFB11(1)	1281917	11	8	10	6	2	2	1	4	2	0	0.907	0.998	1.000
57	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(2), CDKN1A(6), GRIN1(6), HIF1A(3), JAK2(9), NFKB1(7), NFKBIA(2), RELA(4)	3909470	39	34	39	9	4	11	4	13	7	0	0.347	0.998	1.000
58	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNB1(4), GNGT1(1), HTR2C(7), PLCB1(11), TUB(3)	2136478	26	22	25	8	3	5	1	9	8	0	0.704	0.998	1.000
59	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(2), PLCG1(10), PRKCA(2), PTK2B(8)	1992597	22	20	22	6	5	6	0	3	8	0	0.755	0.998	1.000
60	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(2), ACTR3(3), ARPC1A(2), ARPC1B(2), ARPC2(5), ARPC4(2), CDC42(2), PAK1(4), PDGFRA(10), PIK3CA(10), PIK3R1(5), RAC1(1), WASL(2)	4055665	50	41	49	11	12	11	9	11	7	0	0.0777	0.998	1.000
61	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), SHMT1(4), SHMT2(2)	1302428	7	7	7	3	3	1	0	1	2	0	0.772	0.999	1.000
62	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(2), EIF4A1(1), EIF4A2(2), EIF4B(3), EIF4E(2), EIF4EBP1(1), EIF4G1(10), EIF4G2(6), EIF4G3(10), MKNK1(2), PDK2(2), PDPK1(2), PIK3CA(10), PIK3R1(5), PPP2CA(4), PTEN(11), RPS6(1), RPS6KB1(5), TSC1(13), TSC2(15)	8486838	107	70	105	21	18	27	15	17	28	2	0.0204	0.999	1.000
63	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), FDPS(3), GGPS1(2), IDI1(2), IDI2(1), SQLE(3)	1319956	12	12	12	6	2	1	3	3	3	0	0.822	0.999	1.000
64	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(3), ASL(2), CPS1(10), GLS(4), GLUD1(3), GOT1(2)	2315557	24	22	24	8	8	10	0	3	3	0	0.491	0.999	1.000
65	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(6), ACADM(1), ACADS(3), ACAT1(1), ECHS1(2), HADHA(3)	1633180	16	13	16	7	3	4	2	4	3	0	0.695	1.000	1.000
66	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(2), GAD1(5), HDC(5), TH(3), TPH1(3)	1779569	18	17	18	6	6	2	1	4	5	0	0.735	1.000	1.000
67	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(2), ALAS1(2), ALAS2(3), CPO(4), FECH(2), GATA1(3), HMBS(3), UROS(3)	2558587	22	21	21	7	5	2	1	6	8	0	0.692	1.000	1.000
68	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(3), FOS(2), IL3(2), JAK2(9), MAP2K1(5), MAPK3(1), PTPN6(2), RAF1(2), SHC1(5), SOS1(10), STAT5A(2), STAT5B(3)	5409015	46	39	46	9	10	12	8	10	5	1	0.0850	1.000	1.000
69	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(5), NR0B2(3), NR1H3(3), NR1H4(3), RXRA(6)	1593196	20	18	20	6	1	5	4	7	2	1	0.597	1.000	1.000
70	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(4), ARG1(3), GLS(4), GLUD1(3), OAT(3), PRODH(3)	1747356	20	16	20	6	2	7	2	6	3	0	0.576	1.000	1.000
71	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(1), FUT1(2), FUT2(1), FUT9(2), GCNT2(7), ST8SIA1(4)	1837896	17	16	17	5	2	5	1	6	3	0	0.594	1.000	1.000
72	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(3), SNAP25(2), STX1A(1)	933076	6	6	6	3	0	3	0	2	1	0	0.946	1.000	1.000
73	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(1), ATM(15), BRCA1(11), CDKN1A(6), CHEK1(7), CHEK2(6), GADD45A(1), JUN(1), MDM2(2), MRE11A(3), NFKB1(7), NFKBIA(2), RAD50(4), RAD51(5), RBBP8(5), RELA(4), TP53(67), TP73(1)	8834335	148	96	134	30	21	17	16	56	37	1	0.0497	1.000	1.000
74	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(2), AASDHPPT(2), AASS(8), KARS(1)	1410194	13	12	13	5	3	7	0	1	2	0	0.597	1.000	1.000
75	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(1), ALPL(3), ALPP(6), ALPPL2(3), FPGS(4), GGH(1)	2063515	18	17	17	7	1	5	1	8	3	0	0.894	1.000	1.000
76	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(10), PDXK(1), PSAT1(3)	1431980	14	12	14	5	0	9	1	3	1	0	0.668	1.000	1.000
77	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(2), ECHS1(2), HADH(1), HADHA(3), HADHB(2), HSD17B4(8), MECR(3), PPT1(1), PPT2(2)	2587513	24	20	24	8	6	7	4	5	2	0	0.341	1.000	1.000
78	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(1), CSF1(1), IL6(3), LDLR(5), LPL(4)	1580487	14	12	14	8	3	2	3	4	2	0	0.903	1.000	1.000
79	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP2E1(2), PTGS1(3), PTGS2(2)	1574856	7	7	7	8	1	1	1	3	1	0	0.998	1.000	1.000
80	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(2), CAT(1), GH1(2), GHR(8), IGF1(1), IGF1R(12), PIK3CA(10), PIK3R1(5), SHC1(5)	3916943	46	36	45	11	11	10	8	12	5	0	0.147	1.000	1.000
81	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(2), CXCR3(1), ETV5(2), IFNG(3), IL12A(6), IL12B(2), IL12RB1(5), IL12RB2(10), IL18(2), IL18R1(3), JAK2(9), JUN(1), MAP2K6(1), MAPK14(4), STAT4(7), TYK2(7)	5661333	65	51	65	15	11	18	8	17	11	0	0.123	1.000	1.000
82	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(4), LDLR(5), MBTPS1(6), MBTPS2(1), SCAP(4), SREBF1(4), SREBF2(7)	3704930	31	29	31	9	8	7	3	7	6	0	0.357	1.000	1.000
83	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(2), GSR(3), GSS(4), NFKB1(7), NOX1(5), RELA(4), TNF(2), XDH(13)	3042787	40	35	40	10	5	12	7	12	4	0	0.281	1.000	1.000
84	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(1), EPX(8), LPO(8), MPO(11), MTHFR(4), PRDX6(1), SHMT1(4), SHMT2(2), TPO(11)	3459428	51	42	51	13	16	7	9	11	8	0	0.179	1.000	1.000
85	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(3), CD8A(1), CSF1(1), CSF2(2), IL2(1), IL3(2), IL4(1), IL6(3), IL7(2), IL9(1)	1887596	17	15	17	8	2	4	5	4	2	0	0.812	1.000	1.000
86	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(4), CAMP(1), ITPKA(1), ITPKB(2)	1773502	8	7	8	9	3	2	2	0	1	0	0.994	1.000	1.000
87	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(2), GBA(1), SHMT1(4), SHMT2(2)	1740209	9	9	9	5	3	2	1	2	1	0	0.842	1.000	1.000
88	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(2), PSMA2(1), PSMA4(3), PSMA5(1), PSMA6(1), PSMA7(4), PSMB1(2), PSMB2(1), PSMB3(1), PSMB5(3), PSMB6(1), PSMB7(2), PSMC2(2), PSMD1(9), PSMD11(2), PSMD12(4), PSMD13(3), PSMD2(5), PSMD6(2)	4826391	49	35	49	12	7	8	6	22	6	0	0.309	1.000	1.000
89	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(1), B3GALT1(1), B3GALT2(1), FUT1(2), FUT2(1), FUT3(3), ST3GAL3(4), ST3GAL4(1)	2143518	14	10	14	6	4	3	0	5	2	0	0.834	1.000	1.000
90	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(2), EIF4A1(1), EIF4A2(2), EIF4E(2), EIF4EBP1(1), EIF4G1(10), EIF4G2(6), EIF4G3(10), GHR(8), IRS1(4), MAPK1(3), MAPK14(4), MAPK3(1), MKNK1(2), PABPC1(9), PDK2(2), PDPK1(2), PIK3CA(10), PIK3R1(5), PRKCA(2), PTEN(11), RPS6KB1(5)	8558629	102	67	98	23	21	27	18	15	19	2	0.0407	1.000	1.000
91	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(2), CCNE1(2), CDC34(1), CUL1(3), E2F1(2), RB1(19), SKP2(3), TFDP1(3)	2607768	35	31	35	10	5	5	1	5	18	1	0.796	1.000	1.000
92	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(2), CCND1(1), CCNE1(2), CDK6(2), CDKN1A(6), CDKN1B(2), E2F1(2), MAPK1(3), MAPK3(1), NFKB1(7), NFKBIA(2), PAK1(4), PIK3CA(10), PIK3R1(5), RAC1(1), RAF1(2), RB1(19), RELA(4), TFDP1(3)	6087907	78	58	77	20	13	11	8	24	21	1	0.370	1.000	1.000
93	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(2), CD4(3), CD58(2), CD8A(1), IL3(2), IL6(3), KITLG(2)	1877994	15	12	15	7	2	4	5	3	1	0	0.732	1.000	1.000
94	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(2), CDO1(1), CSAD(3), GAD1(5), GAD2(2)	1769236	13	13	13	8	1	4	1	5	2	0	0.970	1.000	1.000
95	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(1), DHRS3(1), DHRS7(2), DHRSX(5), ESCO1(4), ESCO2(5), NAT6(2), PNPLA3(3), SH3GLB1(2)	4858622	25	21	23	6	9	5	2	7	2	0	0.166	1.000	1.000
96	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(3), ST3GAL1(1), ST3GAL4(1), ST3GAL5(2), ST6GALNAC2(3), ST6GALNAC4(1), ST8SIA1(4)	1657593	15	15	15	8	4	5	1	4	1	0	0.927	1.000	1.000
97	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(3), ADORA2A(2), ADORA2B(4), ADORA3(3), LTB4R(1), P2RY1(5), P2RY2(2), P2RY6(1)	1677515	21	18	21	8	1	4	1	14	1	0	0.830	1.000	1.000
98	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(2), CCNA2(2), CCND1(1), CCNE1(2), CCNE2(3), CDKN1B(2), CDKN2A(3), E2F1(2), E2F4(2), PRB1(2)	2659998	21	19	21	9	6	3	2	7	3	0	0.759	1.000	1.000
99	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(2), CD2(2), CD4(3), CXCR3(1), IFNG(3), IL12A(6), IL12B(2), IL12RB1(5), IL12RB2(10), JAK2(9), STAT4(7), TYK2(7)	4510643	57	46	57	15	9	19	4	18	7	0	0.265	1.000	1.000
100	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(2), CHRNB1(4), CHRNG(1), MUSK(9), PIK3CA(10), PIK3R1(5), PTK2(9), PTK2B(8), RAPSN(3), SRC(2), TERT(3), YWHAH(1)	4992702	57	43	56	14	10	17	6	14	10	0	0.232	1.000	1.000
101	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(3), CFL1(3), GNAS(9), GNB1(4), GNGT1(1), LIMK1(2), MAP2K1(5), MAPK1(3), MAPK3(1), NOX1(5), PIK3C2G(11), PLCB1(11), PPP1R12B(5), PRKCA(2), PTK2(9), RAF1(2), ROCK2(8)	7709843	85	64	83	19	18	24	10	21	12	0	0.105	1.000	1.000
102	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(8), AGT(2), AGTR1(3), BDKRB2(4), KNG1(5), NOS3(8), REN(1)	3005927	31	25	30	9	7	6	1	14	3	0	0.605	1.000	1.000
103	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(9), DLL1(2), FURIN(3), NOTCH1(6), PSEN1(2)	2833550	22	20	22	8	8	5	3	4	2	0	0.534	1.000	1.000
104	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(2), CD36(1), FOS(2), FYN(2), JUN(1), MAPK14(4), THBS1(3)	2120615	15	15	15	6	2	1	4	6	2	0	0.801	1.000	1.000
105	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(1), DHRS1(1), DHRS3(1), DHRS7(2), DHRSX(5), HSD3B7(2), PON1(2), PON3(1), RDH11(2), RDH12(2), RDH13(1)	2646994	20	17	18	7	10	2	1	6	1	0	0.614	1.000	1.000
106	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(2), APAF1(10), BCL2(1), CASP3(2), CASP9(1), DAXX(1), FAS(5), FASLG(2), HSPB2(4), IL1A(3), MAPKAPK2(4), MAPKAPK3(1), TNF(2)	3317290	38	35	36	11	7	10	4	11	6	0	0.383	1.000	1.000
107	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(3), CLOCK(4), CRY1(5), CSNK1E(3), PER1(4)	2525756	19	17	19	7	3	10	0	4	2	0	0.638	1.000	1.000
108	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(6), ACOX3(7), FADS2(1), PLA2G12A(2), PLA2G12B(2), PLA2G1B(1), PLA2G2A(1), PLA2G2D(3), PLA2G2E(1), PLA2G2F(6), PLA2G3(4), PLA2G4A(6), PLA2G6(6)	3235681	46	35	45	12	11	7	10	16	2	0	0.200	1.000	1.000
109	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(5), ACP2(1), ACP5(2), ACPP(5), ACPT(1), ENPP1(4), ENPP3(8), FLAD1(4), RFK(1), TYR(6)	2934608	37	24	37	11	5	7	7	15	3	0	0.447	1.000	1.000
110	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(4), CDC25A(2), CDC25B(4), CDC25C(1), CSK(2), PRKCA(2), PTPRA(5), SRC(2)	2772023	22	20	21	7	5	6	2	6	3	0	0.560	1.000	1.000
111	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(2), KLK2(3), NTRK1(5), PIK3CA(10), PIK3R1(5), PLCG1(10), PRKCA(2), SHC1(5), SOS1(10)	4700698	52	41	50	14	15	14	7	10	5	1	0.258	1.000	1.000
112	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(5), IL13RA2(5), IL4R(4), JAK1(8), JAK2(9), TYK2(7)	3124714	38	32	38	10	8	13	1	8	8	0	0.488	1.000	1.000
113	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(5), IL13RA2(5), IL4R(4), JAK1(8), JAK2(9), TYK2(7)	3124714	38	32	38	10	8	13	1	8	8	0	0.488	1.000	1.000
114	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(2), IGF1R(12), IRS1(4), MAP2K1(5), MAPK1(3), MAPK3(1), PIK3CA(10), PIK3R1(5), RAF1(2), SHC1(5), SOS1(10), YWHAH(1)	5615958	60	47	59	16	15	13	9	16	6	1	0.229	1.000	1.000
115	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(2), FOS(2), JAK2(9), JUN(1), MAP2K1(5), MAPK3(1), PLCG1(10), PTPN6(2), RAF1(2), SHC1(5), SOS1(10), STAT5A(2), STAT5B(3)	6602849	54	44	54	12	13	17	6	8	9	1	0.189	1.000	1.000
116	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(3), ACO2(4), FH(4), IDH1(7), IDH2(5), MDH1(1), MDH2(2), SDHB(3), SUCLA2(3)	2686497	32	25	30	10	5	4	8	12	3	0	0.487	1.000	1.000
117	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(2), CDKN1B(2), CKS1B(1), CUL1(3), E2F1(2), RB1(19), SKP2(3), TFDP1(3), UBE2M(2)	2570614	37	34	37	11	5	5	1	6	19	1	0.777	1.000	1.000
118	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(2), FOS(2), IGF1(1), IGF1R(12), IRS1(4), JUN(1), MAP2K1(5), MAPK3(1), PIK3CA(10), PIK3R1(5), PTPN11(2), RAF1(2), RASA1(10), SHC1(5), SOS1(10), SRF(1)	7408440	73	54	72	19	14	17	12	18	11	1	0.200	1.000	1.000
119	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(2), GHR(8), INSR(11), IRS1(4), JAK2(9), MAP2K1(5), MAPK1(3), MAPK3(1), PIK3CA(10), PIK3R1(5), PLCG1(10), PRKCA(2), PTPN6(2), RAF1(2), RPS6KA1(4), SHC1(5), SLC2A4(1), SOS1(10), SRF(1), STAT5A(2), STAT5B(3)	9988717	100	67	99	20	29	25	11	20	14	1	0.0193	1.000	1.000
120	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(10), BAX(1), BCL2(1), BID(2), BIK(3), BIRC2(6), BIRC3(6), CASP3(2), CASP6(2), CASP7(4), CASP8(3), CASP9(1), DFFA(2), DFFB(3), DIABLO(3), ENDOG(2)	4038251	51	36	50	15	9	13	4	13	12	0	0.489	1.000	1.000
121	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(2), FOS(2), INSR(11), IRS1(4), JUN(1), MAP2K1(5), MAPK3(1), PIK3CA(10), PIK3R1(5), PTPN11(2), RAF1(2), RASA1(10), SHC1(5), SLC2A4(1), SOS1(10), SRF(1)	7624155	72	53	71	19	14	16	11	19	11	1	0.206	1.000	1.000
122	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(2), CCNB1(4), CCND1(1), CCND2(1), CCNE1(2), CCNH(3), CDC25A(2), CDK6(2), CDK7(1), CDKN1A(6), CDKN1B(2), CDKN2A(3), CDKN2C(1), E2F1(2), RB1(19), RBL1(6), TFDP1(3)	4734825	60	45	60	18	9	9	4	17	20	1	0.611	1.000	1.000
123	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(3), CXCL12(2), CXCR4(2), GNAI1(4), GNB1(4), GNGT1(1), MAP2K1(5), MAPK1(3), MAPK3(1), NFKB1(7), PIK3C2G(11), PIK3CA(10), PIK3R1(5), PLCG1(10), PRKCA(2), PTK2(9), PTK2B(8), PXN(5), RAF1(2), RELA(4)	8474607	98	73	97	25	19	28	11	21	19	0	0.220	1.000	1.000
124	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(2), FOS(2), JAK2(9), JUN(1), MAP2K1(5), MAPK3(1), MPL(1), PIK3CA(10), PIK3R1(5), PLCG1(10), PRKCA(2), RAF1(2), RASA1(10), SHC1(5), SOS1(10), STAT1(7), STAT3(5), STAT5A(2), STAT5B(3), THPO(1)	9046162	93	66	92	22	17	30	11	19	15	1	0.134	1.000	1.000
125	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(5), COASY(3), DPYD(17), ENPP1(4), ENPP3(8), PANK1(1), PANK2(2), PANK3(2), PANK4(2), PPCS(2), UPB1(1)	4159239	47	35	45	14	12	12	8	12	3	0	0.237	1.000	1.000
126	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(2), PIK3CA(10), PIK3R1(5), PLCB1(11), PLCG1(10), PRKCA(2), VAV1(6)	3881926	46	37	45	13	10	12	3	13	8	0	0.498	1.000	1.000
127	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(2), AKT2(7), AKT3(4), BPNT1(2), ILK(1), MAPK1(3), MAPK3(1), PDK1(1), PIK3CA(10), PIK3CD(5), PTEN(11), PTK2B(8), RBL2(8), SHC1(5), SOS1(10)	6043611	78	53	77	22	14	21	11	15	15	2	0.355	1.000	1.000
128	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(2), F2R(2), F2RL3(1), GNAI1(4), GNB1(4), GNGT1(1), ITGA1(7), ITGB1(3), MAP2K1(5), MAPK1(3), MAPK3(1), PLA2G4A(6), PLCB1(11), PRKCA(2), PTGS1(3), PTK2(9), RAF1(2), SRC(2), SYK(4), TBXAS1(2)	7293868	74	61	74	20	11	22	8	24	9	0	0.300	1.000	1.000
129	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(7), AKT1(2), CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), CREB1(1), GNAS(9), MAPK1(3), MAPK14(4), MAPK3(1), PIK3CA(10), PIK3R1(5), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(2), RAC1(1), RPS6KA1(4), RPS6KA5(3), SOS1(10)	8845639	84	59	81	22	23	17	8	23	11	2	0.251	1.000	1.000
130	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(2), FOS(2), IL6(3), IL6R(1), IL6ST(14), JAK1(8), JAK2(9), JAK3(5), JUN(1), MAP2K1(5), MAPK3(1), PTPN11(2), RAF1(2), SHC1(5), SOS1(10), SRF(1), STAT3(5)	7194005	76	57	75	22	9	23	12	17	14	1	0.416	1.000	1.000
131	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(2), FOS(2), JUN(1), KLK2(3), MAP2K1(5), MAPK3(1), NGFR(1), PIK3CA(10), PIK3R1(5), PLCG1(10), RAF1(2), SHC1(5), SOS1(10)	5718655	57	45	55	17	14	14	9	12	7	1	0.344	1.000	1.000
132	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(4), PGAP1(1), PIGA(3), PIGB(3), PIGC(1), PIGF(3), PIGG(5), PIGH(2), PIGL(3), PIGM(6), PIGN(8), PIGO(4), PIGQ(5), PIGS(6), PIGU(2), PIGV(1), PIGW(4), PIGX(2), PIGZ(4)	7459856	67	41	67	19	18	9	4	23	13	0	0.389	1.000	1.000
133	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(7), ARHGEF1(3), F2(2), F2R(2), F2RL3(1), GNA12(1), GNA13(2), GNAI1(4), GNB1(4), GNGT1(1), MAP3K7(3), PIK3CA(10), PIK3R1(5), PLCB1(11), PPP1R12B(5), PRKCA(2), PTK2B(8), ROCK1(7)	7725934	78	54	77	21	11	19	8	23	17	0	0.398	1.000	1.000
134	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(7), ADCY2(10), ADCY3(7), ADCY4(6), ADCY7(3), ADCY8(12), ADCY9(9), ADORA2A(2), ADORA2B(4), ADRA1A(3), ADRA1B(2), ADRA1D(3), ADRB1(1), ADRB2(5), ADRB3(1), AGTR1(3), ATP2A1(4), ATP2A2(2), ATP2A3(3), ATP2B1(8), ATP2B2(6), ATP2B3(3), ATP2B4(4), AVPR1B(2), BDKRB1(2), BDKRB2(4), BST1(2), CACNA1A(7), CACNA1B(15), CACNA1C(8), CACNA1D(9), CACNA1E(28), CACNA1F(7), CACNA1G(7), CACNA1H(13), CACNA1I(6), CACNA1S(7), CALM1(1), CALML6(1), CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(1), CCKBR(4), CD38(2), CHRM2(5), CHRM3(4), CHRM5(3), CHRNA7(1), CYSLTR1(2), CYSLTR2(2), EDNRA(3), EDNRB(2), EGFR(7), ERBB2(4), ERBB3(10), ERBB4(9), F2R(2), GNA14(1), GNA15(2), GNAL(4), GNAS(9), GRIN1(6), GRIN2A(6), GRIN2C(4), GRIN2D(4), GRM1(8), GRM5(5), HRH1(1), HRH2(3), HTR2A(2), HTR2B(4), HTR2C(7), HTR4(1), HTR5A(1), HTR6(4), HTR7(10), ITPKA(1), ITPKB(2), ITPR1(18), ITPR2(19), ITPR3(15), LHCGR(7), MYLK(4), MYLK2(4), NOS1(15), NOS3(8), OXTR(2), P2RX1(2), P2RX2(2), P2RX3(3), P2RX4(1), P2RX5(2), P2RX7(3), PDE1A(2), PDE1B(3), PDE1C(11), PDGFRA(10), PDGFRB(2), PHKA1(10), PHKA2(5), PHKB(11), PHKG1(1), PHKG2(4), PLCB1(11), PLCB2(4), PLCB3(5), PLCB4(16), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(14), PLCG1(10), PLCG2(16), PLCZ1(2), PPID(2), PPP3CA(6), PPP3CB(5), PPP3CC(1), PPP3R1(1), PRKACA(2), PRKACB(3), PRKACG(1), PRKCA(2), PRKCG(2), PRKX(4), PTGER3(2), PTGFR(3), PTK2B(8), RYR1(26), RYR2(47), RYR3(32), SLC25A4(1), SLC25A5(3), SLC25A6(1), SLC8A1(9), SLC8A2(7), SLC8A3(2), SPHK1(6), SPHK2(4), TACR1(5), TACR2(6), TACR3(4), TNNC2(2), TRHR(5), TRPC1(6), VDAC1(1), VDAC2(1), VDAC3(1)	83762403	844	182	835	370	201	180	74	278	107	4	1.000	1.000	1.000
135	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(1), ACTG1(1), ACTN1(5), ACTN2(8), ACTN3(1), ACTN4(2), AKT1(2), AKT2(7), AKT3(4), ARHGAP5(6), BCAR1(3), BCL2(1), BIRC2(6), BIRC3(6), BRAF(2), CAPN2(1), CAV1(1), CAV2(3), CCND1(1), CCND2(1), CDC42(2), COL11A1(18), COL11A2(8), COL1A1(3), COL1A2(7), COL2A1(5), COL3A1(7), COL4A1(7), COL4A2(10), COL4A4(11), COL4A6(11), COL5A1(11), COL5A2(11), COL5A3(5), COL6A1(7), COL6A2(6), COL6A3(20), COL6A6(27), COMP(2), CTNNB1(59), DIAPH1(6), DOCK1(14), EGF(10), EGFR(7), ERBB2(4), FARP2(7), FIGF(1), FLNA(8), FLNB(10), FLNC(10), FLT1(11), FN1(14), FYN(2), GSK3B(6), HGF(9), IBSP(8), IGF1(1), IGF1R(12), ILK(1), ITGA1(7), ITGA10(10), ITGA11(10), ITGA2(7), ITGA2B(5), ITGA3(5), ITGA4(7), ITGA5(4), ITGA6(3), ITGA7(8), ITGA8(6), ITGA9(8), ITGAV(9), ITGB1(3), ITGB3(3), ITGB4(9), ITGB5(7), ITGB6(5), ITGB7(2), ITGB8(9), JUN(1), KDR(13), LAMA1(30), LAMA2(16), LAMA3(20), LAMA4(11), LAMA5(18), LAMB1(5), LAMB2(4), LAMB3(4), LAMB4(12), LAMC1(16), LAMC2(4), LAMC3(7), MAP2K1(5), MAPK1(3), MAPK10(4), MAPK3(1), MAPK9(4), MET(2), MYL5(1), MYL9(1), MYLK(4), MYLK2(4), MYLPF(1), PAK1(4), PAK2(8), PAK3(6), PAK4(3), PAK6(4), PAK7(9), PARVA(3), PARVB(3), PDGFA(2), PDGFB(1), PDGFC(5), PDGFD(2), PDGFRA(10), PDGFRB(2), PDPK1(2), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PIP5K1C(3), PPP1CA(3), PPP1CB(3), PPP1CC(1), PPP1R12A(8), PRKCA(2), PRKCG(2), PTEN(11), PTK2(9), PXN(5), RAC1(1), RAC2(4), RAF1(2), RAP1A(2), RAPGEF1(7), RELN(12), ROCK1(7), ROCK2(8), SHC1(5), SHC2(1), SHC4(5), SOS1(10), SOS2(8), SPP1(1), SRC(2), THBS1(3), THBS2(5), THBS3(5), THBS4(3), TLN1(12), TLN2(11), TNC(11), TNN(12), TNR(11), TNXB(23), VASP(3), VAV1(6), VAV2(2), VAV3(7), VCL(4), VEGFB(2), VEGFC(5), VTN(2), VWF(10), ZYX(2)	113542010	1130	182	1089	494	224	267	129	341	157	12	1.000	1.000	1.000
136	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	248	ACVR1B(3), ACVR1C(1), AKT1(2), AKT2(7), AKT3(4), ARRB1(2), ARRB2(2), ATF2(1), ATF4(6), BDNF(1), BRAF(2), CACNA1A(7), CACNA1B(15), CACNA1C(8), CACNA1D(9), CACNA1E(28), CACNA1F(7), CACNA1G(7), CACNA1H(13), CACNA1I(6), CACNA1S(7), CACNA2D1(11), CACNA2D2(6), CACNA2D3(4), CACNA2D4(8), CACNB1(3), CACNB2(2), CACNB4(7), CACNG1(2), CACNG2(4), CACNG3(2), CACNG4(3), CACNG5(1), CACNG7(1), CACNG8(2), CASP3(2), CDC25B(4), CDC42(2), CHUK(9), DAXX(1), DDIT3(1), DUSP1(1), DUSP14(1), DUSP16(3), DUSP2(1), DUSP6(3), DUSP7(1), DUSP8(1), DUSP9(2), ECSIT(3), EGF(10), EGFR(7), ELK4(2), FAS(5), FASLG(2), FGF10(2), FGF11(1), FGF13(2), FGF14(4), FGF20(3), FGF21(1), FGF3(3), FGF5(2), FGF6(3), FGF8(1), FGF9(1), FGFR1(2), FGFR2(8), FGFR3(6), FGFR4(1), FLNA(8), FLNB(10), FLNC(10), FOS(2), GADD45A(1), GNA12(1), GNG12(1), IKBKB(6), IL1A(3), IL1B(2), IL1R1(4), IL1R2(2), JUN(1), JUND(2), KRAS(4), MAP2K1(5), MAP2K2(3), MAP2K4(4), MAP2K5(1), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K10(1), MAP3K12(2), MAP3K13(3), MAP3K14(2), MAP3K2(1), MAP3K3(2), MAP3K4(9), MAP3K5(6), MAP3K6(8), MAP3K7(3), MAP3K8(2), MAP4K1(5), MAP4K2(4), MAP4K3(6), MAP4K4(9), MAPK1(3), MAPK10(4), MAPK11(4), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(1), MAPK7(6), MAPK8IP3(2), MAPK9(4), MAPKAPK2(4), MAPKAPK3(1), MAPKAPK5(4), MAPT(12), MEF2C(3), MKNK1(2), MKNK2(1), MOS(1), MRAS(1), MYC(2), NF1(14), NFATC2(4), NFATC4(5), NFKB1(7), NFKB2(2), NLK(3), NR4A1(4), NRAS(1), NTF3(1), NTRK1(5), NTRK2(5), PAK1(4), PAK2(8), PDGFA(2), PDGFB(1), PDGFRA(10), PDGFRB(2), PLA2G12A(2), PLA2G12B(2), PLA2G1B(1), PLA2G2A(1), PLA2G2D(3), PLA2G2E(1), PLA2G2F(6), PLA2G3(4), PLA2G4A(6), PLA2G6(6), PPM1B(3), PPP3CA(6), PPP3CB(5), PPP3CC(1), PPP3R1(1), PPP5C(4), PRKACA(2), PRKACB(3), PRKACG(1), PRKCA(2), PRKCG(2), PRKX(4), PTPN5(5), PTPN7(2), PTPRR(4), RAC1(1), RAC2(4), RAF1(2), RAP1A(2), RAPGEF2(8), RASA1(10), RASA2(4), RASGRF1(8), RASGRF2(8), RASGRP1(9), RASGRP2(3), RASGRP3(4), RASGRP4(6), RPS6KA1(4), RPS6KA2(6), RPS6KA3(10), RPS6KA4(1), RPS6KA5(3), RPS6KA6(9), SOS1(10), SOS2(8), SRF(1), STK3(6), STK4(5), STMN1(1), TAOK1(4), TAOK2(6), TAOK3(7), TGFB1(1), TGFB2(4), TGFB3(3), TGFBR1(5), TGFBR2(1), TNF(2), TNFRSF1A(2), TP53(67), TRAF6(1), ZAK(7)	89472107	897	181	877	356	212	194	105	243	137	6	0.997	1.000	1.000
137	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	235	ADCYAP1R1(3), ADORA1(3), ADORA2A(2), ADORA2B(4), ADORA3(3), ADRA1A(3), ADRA1B(2), ADRA2A(1), ADRA2B(1), ADRA2C(1), ADRB1(1), ADRB2(5), ADRB3(1), AGTR1(3), AVPR1B(2), BDKRB1(2), BDKRB2(4), BRS3(2), C3AR1(2), C5AR1(1), CALCR(4), CALCRL(1), CCKBR(4), CHRM2(5), CHRM3(4), CHRM4(1), CHRM5(3), CNR1(3), CNR2(1), CRHR1(3), CRHR2(6), CTSG(1), CYSLTR1(2), CYSLTR2(2), DRD2(2), DRD3(5), DRD5(8), EDNRA(3), EDNRB(2), F2(2), F2R(2), F2RL1(1), F2RL3(1), FPR1(2), FSHR(2), GABBR1(6), GABBR2(2), GABRA1(5), GABRA2(4), GABRA3(3), GABRA4(8), GABRA5(4), GABRA6(6), GABRB1(3), GABRB2(2), GABRB3(4), GABRD(1), GABRE(2), GABRG1(6), GABRG2(2), GABRG3(3), GABRP(1), GABRQ(7), GABRR1(7), GABRR2(9), GALR1(2), GH1(2), GH2(7), GHR(8), GHRHR(2), GHSR(2), GIPR(3), GLP1R(2), GLP2R(6), GLRA1(2), GLRA2(2), GLRA3(3), GLRB(4), GNRHR(2), GPR156(4), GPR35(2), GPR50(5), GPR63(5), GPR83(3), GRIA1(8), GRIA2(10), GRIA3(16), GRIA4(9), GRID1(3), GRID2(8), GRIK1(3), GRIK2(6), GRIK3(4), GRIK4(5), GRIK5(2), GRIN1(6), GRIN2A(6), GRIN2B(10), GRIN2C(4), GRIN2D(4), GRIN3A(7), GRIN3B(5), GRM1(8), GRM2(3), GRM3(6), GRM4(4), GRM5(5), GRM6(5), GRM7(8), GRM8(9), GZMA(3), HCRTR1(3), HCRTR2(2), HRH1(1), HRH2(3), HRH3(2), HRH4(3), HTR1A(1), HTR1B(1), HTR1D(2), HTR1E(2), HTR1F(3), HTR2A(2), HTR2B(4), HTR2C(7), HTR4(1), HTR5A(1), HTR6(4), HTR7(10), KISS1R(1), LEP(1), LEPR(7), LHB(3), LHCGR(7), LTB4R(1), MC1R(1), MC2R(4), MC3R(2), MC4R(2), MC5R(5), MCHR1(2), MCHR2(2), MTNR1A(5), NMBR(3), NMUR1(2), NMUR2(8), NPBWR1(2), NPBWR2(1), NPFFR1(1), NPFFR2(3), NPY1R(4), NPY2R(4), NPY5R(4), NR3C1(4), OPRK1(2), OPRL1(1), OPRM1(10), OXTR(2), P2RX1(2), P2RX2(2), P2RX3(3), P2RX4(1), P2RX5(2), P2RX7(3), P2RY1(5), P2RY10(1), P2RY13(2), P2RY2(2), P2RY4(4), P2RY6(1), P2RY8(4), PARD3(5), PPYR1(2), PRL(2), PRLHR(3), PRSS1(3), PRSS3(6), PTGDR(1), PTGER2(5), PTGER3(2), PTGER4(1), PTGFR(3), PTGIR(2), PTH2R(6), RXFP1(5), RXFP2(5), SCTR(1), SSTR2(2), SSTR3(6), SSTR4(2), SSTR5(1), TAAR1(2), TAAR2(3), TAAR5(2), TAAR6(2), TACR1(5), TACR2(6), TACR3(4), THRA(1), THRB(1), TRHR(5), TRPV1(6), TSHR(4), TSPO(1), UTS2R(1), VIPR1(2), VIPR2(4)	65967748	724	174	705	354	147	146	78	266	87	0	1.000	1.000	1.000
138	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ABI2(2), ACTN1(5), ACTN2(8), ACTN3(1), ACTN4(2), APC(12), APC2(3), ARAF(4), ARHGEF1(3), ARHGEF12(11), ARHGEF4(7), ARHGEF6(4), ARHGEF7(6), ARPC1A(2), ARPC1B(2), ARPC2(5), ARPC4(2), BAIAP2(3), BCAR1(3), BDKRB1(2), BDKRB2(4), BRAF(2), CDC42(2), CFL1(3), CFL2(2), CHRM2(5), CHRM3(4), CHRM4(1), CHRM5(3), CSK(2), CYFIP1(3), CYFIP2(16), DIAPH1(6), DIAPH2(6), DIAPH3(8), DOCK1(14), EGF(10), EGFR(7), EZR(5), F2(2), F2R(2), FGD3(6), FGF10(2), FGF11(1), FGF13(2), FGF14(4), FGF20(3), FGF21(1), FGF3(3), FGF5(2), FGF6(3), FGF8(1), FGF9(1), FGFR1(2), FGFR2(8), FGFR3(6), FGFR4(1), FN1(14), GIT1(2), GNA12(1), GNA13(2), GNG12(1), GSN(2), IQGAP1(10), IQGAP2(7), IQGAP3(5), ITGA1(7), ITGA10(10), ITGA11(10), ITGA2(7), ITGA2B(5), ITGA3(5), ITGA4(7), ITGA5(4), ITGA6(3), ITGA7(8), ITGA8(6), ITGA9(8), ITGAD(12), ITGAE(7), ITGAL(7), ITGAM(7), ITGAV(9), ITGAX(7), ITGB1(3), ITGB2(9), ITGB3(3), ITGB4(9), ITGB5(7), ITGB6(5), ITGB7(2), ITGB8(9), KRAS(4), LIMK1(2), LIMK2(6), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MOS(1), MRAS(1), MSN(6), MYH10(7), MYH14(12), MYH9(4), MYL5(1), MYL9(1), MYLK(4), MYLK2(4), MYLPF(1), NCKAP1(6), NCKAP1L(8), NRAS(1), PAK1(4), PAK2(8), PAK3(6), PAK4(3), PAK6(4), PAK7(9), PDGFA(2), PDGFB(1), PDGFRA(10), PDGFRB(2), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PIP4K2A(2), PIP4K2B(3), PIP4K2C(4), PIP5K1B(2), PIP5K1C(3), PPP1CA(3), PPP1CB(3), PPP1CC(1), PPP1R12A(8), PPP1R12B(5), PTK2(9), PXN(5), RAC1(1), RAC2(4), RAF1(2), RDX(4), ROCK1(7), ROCK2(8), SCIN(9), SLC9A1(1), SOS1(10), SOS2(8), SSH1(3), SSH2(5), SSH3(3), TIAM1(5), TIAM2(7), VAV1(6), VAV2(2), VAV3(7), VCL(4), WAS(2), WASF1(2), WASF2(2), WASL(2)	84953623	789	168	778	341	212	195	75	192	111	4	1.000	1.000	1.000
139	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(1), ACTG1(1), COL11A1(18), COL11A2(8), COL17A1(10), COL1A1(3), COL1A2(7), COL2A1(5), COL3A1(7), COL4A1(7), COL4A2(10), COL4A4(11), COL4A6(11), COL5A1(11), COL5A2(11), COL5A3(5), COL6A1(7), COL6A2(6), COL6A3(20), COL6A6(27), COMP(2), DES(2), DSC1(4), DSC2(7), DSC3(4), DSG1(11), DSG2(6), DSG3(8), DSG4(8), FN1(14), GJA1(4), GJA10(3), GJA3(2), GJA5(2), GJA8(5), GJA9(1), GJB1(1), GJB4(1), GJB5(2), GJB7(5), GJC1(2), GJD2(1), IBSP(8), ITGA6(3), ITGB4(9), KRT1(5), KRT10(1), KRT12(1), KRT13(2), KRT14(5), KRT15(5), KRT16(2), KRT17(4), KRT18(1), KRT19(2), KRT2(5), KRT20(1), KRT23(4), KRT24(4), KRT25(2), KRT27(6), KRT28(2), KRT3(1), KRT31(3), KRT32(7), KRT33A(1), KRT33B(3), KRT34(4), KRT35(9), KRT36(5), KRT37(2), KRT38(5), KRT39(2), KRT4(1), KRT40(11), KRT5(7), KRT6A(2), KRT6B(5), KRT6C(3), KRT7(4), KRT71(5), KRT72(6), KRT73(5), KRT74(1), KRT75(5), KRT76(6), KRT77(3), KRT78(6), KRT79(7), KRT8(1), KRT81(4), KRT82(4), KRT83(4), KRT84(3), KRT85(5), KRT86(4), KRT9(1), LAMA1(30), LAMA2(16), LAMA3(20), LAMA4(11), LAMA5(18), LAMB1(5), LAMB2(4), LAMB3(4), LAMB4(12), LAMC1(16), LAMC2(4), LAMC3(7), LMNA(3), LMNB1(5), LMNB2(4), NES(9), RELN(12), SPP1(1), THBS1(3), THBS2(5), THBS3(5), THBS4(3), TNC(11), TNN(12), TNR(11), TNXB(23), VIM(6), VTN(2), VWF(10)	76000641	770	166	756	390	168	148	103	244	98	9	1.000	1.000	1.000
140	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	145	APC(12), APC2(3), AXIN1(14), AXIN2(8), BTRC(6), CACYBP(1), CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), CCND1(1), CCND2(1), CER1(3), CHD8(8), CREBBP(12), CSNK1A1(1), CSNK1A1L(4), CSNK1E(3), CSNK2A1(2), CSNK2A2(1), CTBP1(2), CTBP2(5), CTNNB1(59), CUL1(3), CXXC4(1), DAAM1(4), DAAM2(3), DKK1(2), DKK2(4), DKK4(1), DVL1(1), DVL2(5), EP300(7), FBXW11(8), FOSL1(1), FZD1(1), FZD10(5), FZD2(3), FZD3(4), FZD4(1), FZD5(2), FZD6(4), FZD7(1), FZD8(2), FZD9(6), GSK3B(6), JUN(1), LEF1(4), LRP5(2), LRP6(6), MAP3K7(3), MAPK10(4), MAPK9(4), MMP7(2), MYC(2), NFAT5(13), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), NKD1(2), NKD2(1), NLK(3), PLCB1(11), PLCB2(4), PLCB3(5), PLCB4(16), PPARD(1), PPP2CA(4), PPP2CB(3), PPP2R1A(4), PPP2R1B(3), PPP2R2B(3), PPP2R2C(4), PPP3CA(6), PPP3CB(5), PPP3CC(1), PPP3R1(1), PRICKLE1(5), PRICKLE2(10), PRKACA(2), PRKACB(3), PRKACG(1), PRKCA(2), PRKCG(2), PRKX(4), PSEN1(2), RAC1(1), RAC2(4), ROCK1(7), ROCK2(8), RUVBL1(1), SENP2(5), SFRP2(1), SFRP4(3), SFRP5(2), SIAH1(6), SMAD2(3), SMAD3(5), TBL1X(1), TBL1XR1(5), TBL1Y(3), TCF7(5), TCF7L1(5), TCF7L2(6), TP53(67), VANGL1(3), VANGL2(1), WIF1(5), WNT1(3), WNT10B(1), WNT16(2), WNT2(3), WNT3A(1), WNT4(1), WNT5B(1), WNT6(2), WNT7A(2), WNT7B(1), WNT8A(2), WNT8B(1), WNT9B(1)	48314374	567	164	519	191	103	113	53	177	116	5	0.847	1.000	1.000
141	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(4), CD36(1), CD44(3), CD47(1), COL11A1(18), COL11A2(8), COL1A1(3), COL1A2(7), COL2A1(5), COL3A1(7), COL4A1(7), COL4A2(10), COL4A4(11), COL4A6(11), COL5A1(11), COL5A2(11), COL5A3(5), COL6A1(7), COL6A2(6), COL6A3(20), COL6A6(27), FN1(14), FNDC1(9), FNDC3A(4), GP5(1), GP6(8), HMMR(5), HSPG2(20), IBSP(8), ITGA1(7), ITGA10(10), ITGA11(10), ITGA2(7), ITGA2B(5), ITGA3(5), ITGA4(7), ITGA5(4), ITGA6(3), ITGA7(8), ITGA8(6), ITGA9(8), ITGAV(9), ITGB1(3), ITGB3(3), ITGB4(9), ITGB5(7), ITGB6(5), ITGB7(2), ITGB8(9), LAMA1(30), LAMA2(16), LAMA3(20), LAMA4(11), LAMA5(18), LAMB1(5), LAMB2(4), LAMB3(4), LAMB4(12), LAMC1(16), LAMC2(4), LAMC3(7), RELN(12), SDC3(1), SPP1(1), SV2A(3), SV2B(3), SV2C(3), THBS1(3), THBS2(5), THBS3(5), THBS4(3), TNC(11), TNN(12), TNR(11), TNXB(23), VTN(2), VWF(10)	69014155	634	161	624	338	144	132	74	192	82	10	1.000	1.000	1.000
142	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY1(7), ADCY2(10), ADCY3(7), ADCY4(6), ADCY5(5), ADCY6(9), ADCY7(3), ADCY8(12), ADCY9(9), ADRA1A(3), ADRA1B(2), ADRA1D(3), ADRB1(1), ADRB2(5), ADRB3(1), ANXA6(3), ARRB1(2), ARRB2(2), ATP1A4(8), ATP1B1(2), ATP1B2(1), ATP1B3(3), ATP2A2(2), ATP2A3(3), ATP2B1(8), ATP2B2(6), ATP2B3(3), CACNA1A(7), CACNA1B(15), CACNA1C(8), CACNA1D(9), CACNA1E(28), CACNA1S(7), CACNB1(3), CALM1(1), CALR(6), CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(1), CASQ1(3), CASQ2(3), CHRM2(5), CHRM3(4), CHRM4(1), CHRM5(3), GJA1(4), GJA5(2), GJB1(1), GJB4(1), GJB5(2), GNAI2(2), GNAI3(1), GNAO1(2), GNB1(4), GNB2(2), GNB4(1), GNB5(6), GNG12(1), GNG5(1), GNGT1(1), GRK4(3), GRK5(2), GRK6(2), ITPR1(18), ITPR2(19), ITPR3(15), KCNJ3(1), KCNJ5(1), MIB1(4), PLCB3(5), PRKACA(2), PRKACB(3), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(2), PRKCD(4), PRKCG(2), PRKCH(2), PRKCQ(2), PRKCZ(3), PRKD1(7), RGS10(1), RGS11(4), RGS14(4), RGS16(4), RGS17(1), RGS18(2), RGS20(2), RGS3(3), RGS4(2), RGS5(1), RGS6(4), RGS7(5), RGS9(5), RYR1(26), RYR2(47), RYR3(32), SFN(1), SLC8A1(9), SLC8A3(2), USP5(6), YWHAB(2), YWHAH(1)	57980811	540	159	537	240	117	123	49	188	60	3	1.000	1.000	1.000
143	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(1), ABLIM1(4), ABLIM2(2), ABLIM3(2), ARHGEF12(11), CDC42(2), CDK5(1), CFL1(3), CFL2(2), CXCL12(2), CXCR4(2), DCC(12), DPYSL2(2), DPYSL5(4), EFNA1(1), EFNA3(2), EFNA4(1), EFNA5(2), EFNB2(3), EPHA1(6), EPHA2(5), EPHA3(10), EPHA4(3), EPHA5(10), EPHA6(10), EPHA7(8), EPHA8(4), EPHB1(6), EPHB2(7), EPHB3(7), EPHB4(1), FES(2), FYN(2), GNAI1(4), GNAI2(2), GNAI3(1), GSK3B(6), ITGB1(3), KRAS(4), L1CAM(5), LIMK1(2), LIMK2(6), LRRC4C(5), MAPK1(3), MAPK3(1), MET(2), NCK1(1), NCK2(2), NFAT5(13), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), NGEF(3), NRAS(1), NRP1(3), NTN1(1), NTN4(4), NTNG1(2), PAK1(4), PAK2(8), PAK3(6), PAK4(3), PAK6(4), PAK7(9), PLXNA1(10), PLXNA2(10), PLXNA3(7), PLXNB1(7), PLXNB2(10), PLXNB3(12), PLXNC1(11), PPP3CA(6), PPP3CB(5), PPP3CC(1), PPP3R1(1), PTK2(9), RAC1(1), RAC2(4), RASA1(10), RGS3(3), RND1(1), ROBO1(12), ROBO2(10), ROBO3(3), ROCK1(7), ROCK2(8), SEMA3A(12), SEMA3C(10), SEMA3D(16), SEMA3E(8), SEMA3F(5), SEMA3G(2), SEMA4A(4), SEMA4B(2), SEMA4C(2), SEMA4D(5), SEMA4F(4), SEMA4G(1), SEMA5A(1), SEMA5B(6), SEMA6A(8), SEMA6B(2), SEMA6C(4), SEMA6D(11), SEMA7A(5), SLIT1(8), SLIT2(15), SLIT3(7), SRGAP1(9), SRGAP2(2), SRGAP3(7), UNC5B(1), UNC5C(3), UNC5D(10)	59796352	582	159	580	267	116	128	69	187	80	2	1.000	1.000	1.000
144	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTB(1), ACTG1(1), ACTN1(5), ACTN2(8), ACTN3(1), ACTN4(2), AKT1(2), AKT2(7), AKT3(4), AMOTL1(4), ASH1L(11), CASK(5), CDC42(2), CGN(4), CLDN1(1), CLDN10(1), CLDN16(3), CLDN17(1), CLDN18(3), CLDN19(1), CLDN2(1), CLDN20(2), CLDN23(1), CLDN3(1), CLDN4(1), CLDN5(1), CLDN6(2), CLDN7(2), CLDN8(2), CRB3(1), CSNK2A1(2), CSNK2A2(1), CTNNA1(1), CTNNA2(10), CTNNA3(3), CTNNB1(59), CTTN(5), EPB41(3), EPB41L1(4), EPB41L2(5), EPB41L3(8), EXOC3(5), EXOC4(7), F11R(1), GNAI1(4), GNAI2(2), GNAI3(1), IGSF5(7), INADL(21), JAM2(3), JAM3(3), KRAS(4), LLGL1(2), LLGL2(6), MAGI1(6), MAGI2(8), MAGI3(7), MLLT4(7), MPDZ(13), MPP5(4), MRAS(1), MYH1(12), MYH10(7), MYH11(10), MYH13(8), MYH14(12), MYH15(16), MYH2(14), MYH3(13), MYH4(11), MYH6(10), MYH7(16), MYH7B(3), MYH8(10), MYH9(4), MYL5(1), MYL9(1), MYLPF(1), NRAS(1), OCLN(1), PARD3(5), PARD6B(2), PPP2CA(4), PPP2CB(3), PPP2R1A(4), PPP2R1B(3), PPP2R2B(3), PPP2R2C(4), PPP2R3A(6), PPP2R3B(5), PPP2R4(4), PRKCA(2), PRKCD(4), PRKCG(2), PRKCH(2), PRKCI(1), PRKCQ(2), PRKCZ(3), PTEN(11), RAB3B(1), SPTAN1(9), SRC(2), SYMPK(4), TJAP1(2), TJP1(9), TJP2(8), VAPA(1), YES1(4), ZAK(7)	58351224	562	158	525	253	115	127	62	177	77	4	1.000	1.000	1.000
145	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	109	ABL1(1), ANAPC1(3), ANAPC10(1), ANAPC2(4), ANAPC4(1), ANAPC5(6), ANAPC7(3), ATM(15), ATR(14), BUB1(6), BUB1B(6), BUB3(2), CCNA1(2), CCNA2(2), CCNB1(4), CCNB2(2), CCNB3(8), CCND1(1), CCND2(1), CCNE1(2), CCNE2(3), CCNH(3), CDC14A(2), CDC14B(3), CDC16(4), CDC20(1), CDC23(3), CDC25A(2), CDC25B(4), CDC25C(1), CDC27(16), CDC6(1), CDC7(4), CDK6(2), CDK7(1), CDKN1A(6), CDKN1B(2), CDKN2A(3), CDKN2C(1), CHEK1(7), CHEK2(6), CREBBP(12), CUL1(3), DBF4(1), E2F1(2), E2F3(2), EP300(7), ESPL1(7), FZR1(4), GADD45A(1), GSK3B(6), HDAC2(5), MAD1L1(2), MAD2L1(1), MAD2L2(2), MCM2(5), MCM3(3), MCM4(4), MCM5(3), MCM6(4), MCM7(6), MDM2(2), PKMYT1(1), PLK1(3), PRKDC(26), PTTG1(2), PTTG2(2), RB1(19), RBL1(6), RBL2(8), SFN(1), SKP2(3), SMAD2(3), SMAD3(5), SMC1A(7), SMC1B(12), TFDP1(3), TGFB1(1), TGFB2(4), TGFB3(3), TP53(67), WEE1(4), YWHAB(2), YWHAE(2), YWHAG(2), YWHAH(1), YWHAZ(1)	41312547	429	153	404	152	69	89	45	129	95	2	0.839	1.000	1.000
146	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(5), CADM1(6), CADM3(1), CD2(2), CD22(9), CD226(3), CD276(1), CD4(3), CD40(4), CD58(2), CD6(4), CD80(1), CD86(4), CD8A(1), CD8B(4), CD99(4), CDH1(4), CDH15(5), CDH2(4), CDH3(5), CDH4(5), CDH5(5), CLDN1(1), CLDN10(1), CLDN16(3), CLDN17(1), CLDN18(3), CLDN19(1), CLDN2(1), CLDN20(2), CLDN23(1), CLDN3(1), CLDN4(1), CLDN5(1), CLDN6(2), CLDN7(2), CLDN8(2), CNTN1(8), CNTN2(5), CNTNAP1(1), CNTNAP2(8), CTLA4(3), F11R(1), GLG1(7), HLA-A(11), HLA-B(6), HLA-C(1), HLA-DMA(4), HLA-DMB(4), HLA-DOA(1), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(8), HLA-DQA1(4), HLA-DQA2(1), HLA-DQB1(3), HLA-DRB1(4), HLA-DRB5(3), HLA-E(4), HLA-G(1), ICAM1(2), ICAM3(2), ICOSLG(2), ITGA4(7), ITGA6(3), ITGA8(6), ITGA9(8), ITGAL(7), ITGAM(7), ITGAV(9), ITGB1(3), ITGB2(9), ITGB7(2), ITGB8(9), JAM2(3), JAM3(3), L1CAM(5), MADCAM1(4), MAG(3), NCAM1(6), NCAM2(4), NEGR1(4), NEO1(7), NFASC(7), NLGN1(11), NLGN2(1), NLGN3(3), NRCAM(10), NRXN1(7), NRXN2(5), NRXN3(7), OCLN(1), PDCD1(2), PDCD1LG2(2), PECAM1(1), PTPRC(9), PTPRF(4), PTPRM(16), PVR(1), PVRL1(2), PVRL2(4), PVRL3(3), SDC3(1), SELE(2), SELL(2), SELP(8), SELPLG(3), SIGLEC1(10), SPN(3), VCAM1(3), VCAN(18)	44497137	458	152	451	226	117	96	56	132	57	0	1.000	1.000	1.000
147	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	252	ACVR1(4), ACVR1B(3), ACVR2A(11), ACVR2B(4), AMH(1), AMHR2(1), BMP2(3), BMP7(3), BMPR1A(1), BMPR1B(2), BMPR2(8), CCL1(2), CCL11(1), CCL13(1), CCL14(1), CCL15(4), CCL16(1), CCL18(1), CCL19(1), CCL23(1), CCL24(1), CCL25(1), CCL26(1), CCL3(1), CCL8(2), CCR1(3), CCR2(4), CCR3(3), CCR5(2), CCR6(4), CCR7(4), CCR8(1), CCR9(2), CD27(1), CD40(4), CD70(1), CLCF1(1), CNTFR(2), CRLF2(3), CSF1(1), CSF1R(3), CSF2(2), CSF2RA(4), CSF2RB(3), CSF3R(1), CX3CL1(1), CX3CR1(4), CXCL1(1), CXCL12(2), CXCL14(1), CXCL16(1), CXCL5(1), CXCR3(1), CXCR4(2), CXCR6(2), EDA(4), EDA2R(1), EDAR(3), EGF(10), EGFR(7), FAS(5), FASLG(2), FLT1(11), FLT3(10), FLT3LG(2), FLT4(9), GDF5(4), GH1(2), GH2(7), GHR(8), HGF(9), IFNA13(1), IFNA14(2), IFNA16(2), IFNA17(6), IFNA2(2), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(5), IFNA8(2), IFNAR1(5), IFNAR2(1), IFNB1(1), IFNG(3), IFNGR1(5), IFNGR2(2), IFNW1(2), IL10RA(7), IL10RB(2), IL11RA(1), IL12A(6), IL12B(2), IL12RB1(5), IL12RB2(10), IL13RA1(5), IL15RA(1), IL17RA(2), IL17RB(1), IL18(2), IL18R1(3), IL18RAP(5), IL19(1), IL1A(3), IL1B(2), IL1R1(4), IL1R2(2), IL1RAP(4), IL2(1), IL20(1), IL20RA(4), IL21(1), IL21R(8), IL22(2), IL22RA1(1), IL23A(1), IL23R(3), IL2RA(2), IL2RB(3), IL2RG(1), IL3(2), IL4(1), IL4R(4), IL5RA(2), IL6(3), IL6R(1), IL6ST(14), IL7(2), IL7R(10), IL9(1), IL9R(5), INHBA(2), INHBC(3), INHBE(1), KDR(13), KIT(10), KITLG(2), LEP(1), LEPR(7), LIF(1), LIFR(6), LTA(2), LTBR(1), MET(2), MPL(1), NGFR(1), OSMR(3), PDGFB(1), PDGFC(5), PDGFRA(10), PDGFRB(2), PF4V1(1), PLEKHO2(2), PPBP(1), PRL(2), RELT(3), TGFB1(1), TGFB2(4), TGFB3(3), TGFBR1(5), TGFBR2(1), TNF(2), TNFRSF10A(4), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(5), TNFRSF11A(1), TNFRSF11B(5), TNFRSF13B(1), TNFRSF14(2), TNFRSF17(1), TNFRSF18(1), TNFRSF19(1), TNFRSF1A(2), TNFRSF1B(3), TNFRSF21(6), TNFRSF25(3), TNFRSF4(3), TNFRSF6B(2), TNFRSF8(3), TNFSF10(2), TNFSF11(1), TNFSF13(2), TNFSF13B(2), TNFSF14(1), TNFSF18(1), TNFSF8(1), TPO(11), TSLP(1), VEGFB(2), VEGFC(5), XCL2(1), XCR1(2)	53572717	582	151	574	200	111	130	65	181	92	3	0.762	1.000	1.000
148	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(5), ACTN2(8), ACTN3(1), ACTN4(2), ARHGAP5(6), BCAR1(3), CD99(4), CDC42(2), CDH5(5), CLDN1(1), CLDN10(1), CLDN16(3), CLDN17(1), CLDN18(3), CLDN19(1), CLDN2(1), CLDN20(2), CLDN23(1), CLDN3(1), CLDN4(1), CLDN5(1), CLDN6(2), CLDN7(2), CLDN8(2), CTNNA1(1), CTNNA2(10), CTNNA3(3), CTNNB1(59), CTNND1(3), CXCL12(2), CXCR4(2), CYBA(2), CYBB(4), EZR(5), F11R(1), GNAI1(4), GNAI2(2), GNAI3(1), ICAM1(2), ITGA4(7), ITGAL(7), ITGAM(7), ITGB1(3), ITGB2(9), ITK(2), JAM2(3), JAM3(3), MAPK11(4), MAPK12(2), MAPK13(1), MAPK14(4), MLLT4(7), MMP2(1), MMP9(4), MSN(6), MYL5(1), MYL9(1), MYLPF(1), NCF2(4), NCF4(1), NOX1(5), NOX3(6), OCLN(1), PECAM1(1), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PLCG1(10), PLCG2(16), PRKCA(2), PRKCG(2), PTK2(9), PTK2B(8), PTPN11(2), PXN(5), RAC1(1), RAC2(4), RAP1A(2), RAPGEF3(4), RAPGEF4(3), RASSF5(2), RHOH(1), ROCK1(7), ROCK2(8), SIPA1(1), TXK(3), VASP(3), VAV1(6), VAV2(2), VAV3(7), VCAM1(3), VCL(4)	37804084	413	151	377	127	95	107	39	115	56	1	0.417	1.000	1.000
149	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(1), ATM(15), BUB1(6), BUB1B(6), BUB3(2), CCNA1(2), CCNA2(2), CCNB1(4), CCNB2(2), CCNB3(8), CCND2(1), CCNE1(2), CCNE2(3), CCNH(3), CDAN1(7), CDC14A(2), CDC14B(3), CDC20(1), CDC25A(2), CDC25B(4), CDC25C(1), CDC6(1), CDC7(4), CDH1(4), CDKN1A(6), CDKN2A(3), CHEK1(7), CHEK2(6), DTX4(1), E2F1(2), E2F3(2), E2F4(2), E2F5(3), E2F6(3), EP300(7), ESPL1(7), GADD45A(1), GSK3B(6), HDAC2(5), HDAC3(2), HDAC4(5), HDAC5(3), HDAC6(8), HDAC8(1), MAD1L1(2), MAD2L1(1), MAD2L2(2), MCM2(5), MCM3(3), MCM4(4), MCM5(3), MCM6(4), MCM7(6), MDM2(2), MPEG1(5), MPL(1), PLK1(3), PRKDC(26), PTPRA(5), PTTG1(2), PTTG2(2), RB1(19), RBL1(6), SKP2(3), TBC1D8(7), TFDP1(3), TGFB1(1), TP53(67), WEE1(4)	33603009	352	150	334	96	66	62	39	102	82	1	0.0782	1.000	1.000
150	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(10), ACACB(14), AKT1(2), AKT2(7), AKT3(4), ARAF(4), BRAF(2), CALM1(1), CALML6(1), CBL(8), CBLB(4), EIF4EBP1(1), EXOC7(5), FASN(18), FBP1(2), FBP2(1), FLOT1(6), FLOT2(1), G6PC(4), G6PC2(4), GCK(3), GSK3B(6), GYS1(2), GYS2(5), IKBKB(6), INPP5D(3), INSR(11), IRS1(4), IRS2(2), IRS4(9), KRAS(4), LIPE(6), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK10(4), MAPK3(1), MAPK9(4), MKNK1(2), MKNK2(1), NRAS(1), PCK1(6), PDE3A(7), PDE3B(9), PDPK1(2), PFKL(3), PFKM(2), PFKP(6), PHKA1(10), PHKA2(5), PHKB(11), PHKG1(1), PHKG2(4), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PKLR(1), PPARGC1A(4), PPP1CA(3), PPP1CB(3), PPP1CC(1), PPP1R3A(6), PPP1R3B(1), PPP1R3C(2), PRKAA1(4), PRKAA2(4), PRKAB1(1), PRKAB2(1), PRKACA(2), PRKACB(3), PRKACG(1), PRKAG2(3), PRKAG3(2), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCI(1), PRKCZ(3), PRKX(4), PTPN1(2), PTPRF(4), PYGB(1), PYGL(8), PYGM(9), RAF1(2), RAPGEF1(7), RHOQ(1), RPS6(1), RPS6KB1(5), RPS6KB2(3), SH2B2(1), SHC1(5), SHC2(1), SHC4(5), SLC2A4(1), SOCS4(1), SORBS1(5), SOS1(10), SOS2(8), SREBF1(4), TRIP10(3), TSC1(13), TSC2(15)	48774293	467	149	463	184	128	107	52	104	73	3	0.962	1.000	1.000
151	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ACTA1(2), ACTA2(1), ADCY1(7), ADCY2(10), ADCY3(7), ADCY4(6), ADCY5(5), ADCY6(9), ADCY7(3), ADCY8(12), ADCY9(9), ARRB1(2), ARRB2(2), ATF1(2), ATF2(1), ATF3(2), ATF4(6), ATF5(1), ATP2A2(2), ATP2A3(3), CALCA(3), CALM1(1), CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), CNN2(1), CORIN(6), CREB3(2), CRHR1(3), DGKZ(7), ETS2(2), FOS(2), GABPA(1), GABPB2(2), GJA1(4), GNB1(4), GNB2(2), GNB4(1), GNB5(6), GNG12(1), GNG5(1), GNGT1(1), GRK4(3), GRK5(2), GRK6(2), GUCA2A(1), GUCA2B(2), GUCY1A3(3), IGFBP2(1), IGFBP3(1), IGFBP4(2), IL1B(2), IL6(3), ITPR1(18), ITPR2(19), ITPR3(15), JUN(1), MIB1(4), MYLK2(4), NFKB1(7), NOS1(15), NOS3(8), OXTR(2), PDE4B(3), PDE4D(8), PLCB3(5), PLCD1(1), PLCG1(10), PLCG2(16), PRKACA(2), PRKACB(3), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(2), PRKCD(4), PRKCH(2), PRKCQ(2), PRKCZ(3), PRKD1(7), RGS10(1), RGS11(4), RGS14(4), RGS16(4), RGS17(1), RGS18(2), RGS20(2), RGS3(3), RGS4(2), RGS5(1), RGS6(4), RGS7(5), RGS9(5), RYR1(26), RYR2(47), RYR3(32), SFN(1), SLC8A1(9), SP1(2), TNXB(23), USP5(6), YWHAB(2), YWHAH(1)	53219325	530	148	525	228	110	119	54	176	67	4	1.000	1.000	1.000
152	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	152	AKT1(2), AKT2(7), AKT3(4), CBL(8), CBLB(4), CCND1(1), CCND2(1), CISH(2), CLCF1(1), CNTFR(2), CREBBP(12), CRLF2(3), CSF2(2), CSF2RA(4), CSF2RB(3), CSF3R(1), EP300(7), GH1(2), GH2(7), GHR(8), IFNA13(1), IFNA14(2), IFNA16(2), IFNA17(6), IFNA2(2), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(5), IFNA8(2), IFNAR1(5), IFNAR2(1), IFNB1(1), IFNG(3), IFNGR1(5), IFNGR2(2), IFNW1(2), IL10RA(7), IL10RB(2), IL11RA(1), IL12A(6), IL12B(2), IL12RB1(5), IL12RB2(10), IL13RA1(5), IL13RA2(5), IL15RA(1), IL19(1), IL2(1), IL20(1), IL20RA(4), IL21(1), IL21R(8), IL22(2), IL22RA1(1), IL23A(1), IL23R(3), IL2RA(2), IL2RB(3), IL2RG(1), IL3(2), IL4(1), IL4R(4), IL5RA(2), IL6(3), IL6R(1), IL6ST(14), IL7(2), IL7R(10), IL9(1), IL9R(5), IRF9(2), JAK1(8), JAK2(9), JAK3(5), LEP(1), LEPR(7), LIF(1), LIFR(6), MPL(1), MYC(2), OSMR(3), PIAS1(1), PIAS2(3), PIAS4(1), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PIM1(2), PRL(2), PTPN11(2), PTPN6(2), SOCS4(1), SOCS5(1), SOCS7(1), SOS1(10), SOS2(8), SPRY1(1), SPRY2(2), SPRY3(2), SPRY4(1), STAM(3), STAM2(1), STAT1(7), STAT2(6), STAT3(5), STAT4(7), STAT5A(2), STAT5B(3), STAT6(6), TPO(11), TSLP(1), TYK2(7)	43930042	435	147	426	161	94	102	46	125	67	1	0.926	1.000	1.000
153	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(7), ADCY2(10), ADCY3(7), ADCY4(6), ADCY5(5), ADCY6(9), ADCY7(3), ADCY8(12), ADCY9(9), ADRB1(1), DRD2(2), EGF(10), EGFR(7), GJA1(4), GJD2(1), GNAI1(4), GNAI2(2), GNAI3(1), GNAS(9), GRM1(8), GRM5(5), GUCY1A2(5), GUCY1A3(3), GUCY1B3(7), GUCY2C(6), GUCY2D(3), GUCY2F(9), HTR2A(2), HTR2B(4), HTR2C(7), ITPR1(18), ITPR2(19), ITPR3(15), KRAS(4), MAP2K1(5), MAP2K2(3), MAP2K5(1), MAP3K2(1), MAPK1(3), MAPK3(1), MAPK7(6), NPR1(3), NPR2(6), NRAS(1), PDGFA(2), PDGFB(1), PDGFC(5), PDGFD(2), PDGFRA(10), PDGFRB(2), PLCB1(11), PLCB2(4), PLCB3(5), PLCB4(16), PRKACA(2), PRKACB(3), PRKACG(1), PRKCA(2), PRKCG(2), PRKG1(5), PRKG2(11), PRKX(4), RAF1(2), SOS1(10), SOS2(8), SRC(2), TJP1(9), TUBA1A(1), TUBA1C(1), TUBA3C(5), TUBA3D(3), TUBA3E(17), TUBA4A(1), TUBA8(4), TUBAL3(3), TUBB(1), TUBB1(3), TUBB2A(1), TUBB2B(1), TUBB3(1), TUBB6(1), TUBB8(3)	40250261	419	146	404	170	102	96	43	121	53	4	0.993	1.000	1.000
154	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	82	AKT1(2), AKT2(7), AKT3(4), APAF1(10), ATM(15), BAX(1), BCL2(1), BID(2), BIRC2(6), BIRC3(6), CAPN1(3), CAPN2(1), CASP10(4), CASP3(2), CASP6(2), CASP7(4), CASP8(3), CASP9(1), CFLAR(2), CHUK(9), CSF2RB(3), DFFA(2), DFFB(3), ENDOG(2), FADD(2), FAS(5), FASLG(2), IKBKB(6), IL1A(3), IL1B(2), IL1R1(4), IL1RAP(4), IL3(2), IRAK1(6), IRAK2(3), IRAK3(4), IRAK4(9), MAP3K14(2), MYD88(3), NFKB1(7), NFKB2(2), NFKBIA(2), NTRK1(5), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PPP3CA(6), PPP3CB(5), PPP3CC(1), PPP3R1(1), PRKACA(2), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), RELA(4), RIPK1(6), TNF(2), TNFRSF10A(4), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(5), TNFRSF1A(2), TNFSF10(2), TP53(67)	25424381	334	141	317	89	66	69	35	97	66	1	0.0649	1.000	1.000
155	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(4), BID(2), BRAF(2), CASP3(2), CD244(4), CD247(1), CD48(1), CSF2(2), FAS(5), FASLG(2), FCGR3A(1), FCGR3B(6), FYN(2), GZMB(1), HLA-A(11), HLA-B(6), HLA-C(1), HLA-E(4), HLA-G(1), ICAM1(2), IFNA13(1), IFNA14(2), IFNA16(2), IFNA17(6), IFNA2(2), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(5), IFNA8(2), IFNAR1(5), IFNAR2(1), IFNB1(1), IFNG(3), IFNGR1(5), IFNGR2(2), ITGAL(7), ITGB2(9), KIR2DL1(4), KIR2DL3(7), KIR3DL1(2), KLRC1(1), KLRC2(1), KLRD1(1), KRAS(4), LCK(5), LCP2(4), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MICA(10), MICB(1), NCR1(2), NCR2(4), NCR3(1), NFAT5(13), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), NRAS(1), PAK1(4), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PLCG1(10), PLCG2(16), PPP3CA(6), PPP3CB(5), PPP3CC(1), PPP3R1(1), PRF1(4), PRKCA(2), PRKCG(2), PTK2B(8), PTPN11(2), PTPN6(2), RAC1(1), RAC2(4), RAF1(2), SH2D1A(2), SH2D1B(1), SH3BP2(4), SHC1(5), SHC2(1), SHC4(5), SOS1(10), SOS2(8), SYK(4), TNF(2), TNFRSF10A(4), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(5), TNFSF10(2), TYROBP(1), ULBP1(1), ULBP2(1), VAV1(6), VAV2(2), VAV3(7), ZAP70(3)	34174096	402	141	393	135	94	94	43	119	50	2	0.658	1.000	1.000
156	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(4), BRAF(2), CACNA1A(7), CRHR1(3), GNA12(1), GNA13(2), GNAI1(4), GNAI2(2), GNAI3(1), GNAO1(2), GNAS(9), GRIA1(8), GRIA2(10), GRIA3(16), GRID2(8), GRM1(8), GRM5(5), GUCY1A2(5), GUCY1A3(3), GUCY1B3(7), GUCY2C(6), GUCY2D(3), GUCY2F(9), IGF1(1), IGF1R(12), ITPR1(18), ITPR2(19), ITPR3(15), KRAS(4), LYN(3), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), NOS1(15), NOS3(8), NPR1(3), NPR2(6), NRAS(1), PLA2G12A(2), PLA2G12B(2), PLA2G1B(1), PLA2G2A(1), PLA2G2D(3), PLA2G2E(1), PLA2G2F(6), PLA2G3(4), PLA2G4A(6), PLA2G6(6), PLCB1(11), PLCB2(4), PLCB3(5), PLCB4(16), PPP2CA(4), PPP2CB(3), PPP2R1A(4), PPP2R1B(3), PPP2R2B(3), PPP2R2C(4), PRKCA(2), PRKCG(2), PRKG1(5), PRKG2(11), RAF1(2), RYR1(26)	33804427	379	141	370	158	87	86	40	123	42	1	0.997	1.000	1.000
157	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(7), ADCY2(10), ADCY3(7), ADCY4(6), ADCY5(5), ADCY6(9), ADCY7(3), ADCY8(12), ADCY9(9), CALM1(1), CALML6(1), CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), CREB1(1), CREB3(2), CREB3L1(5), CREB3L2(2), CREB3L3(4), CREB3L4(3), CREBBP(12), CTNNB1(59), DCT(5), DVL1(1), DVL2(5), EDN1(2), EDNRB(2), EP300(7), FZD1(1), FZD10(5), FZD2(3), FZD3(4), FZD4(1), FZD5(2), FZD6(4), FZD7(1), FZD8(2), FZD9(6), GNAI1(4), GNAI2(2), GNAI3(1), GNAO1(2), GNAS(9), GSK3B(6), KIT(10), KITLG(2), KRAS(4), LEF1(4), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MC1R(1), MITF(3), NRAS(1), PLCB1(11), PLCB2(4), PLCB3(5), PLCB4(16), POMC(2), PRKACA(2), PRKACB(3), PRKACG(1), PRKCA(2), PRKCG(2), PRKX(4), RAF1(2), TCF7(5), TCF7L1(5), TCF7L2(6), TYR(6), TYRP1(2), WNT1(3), WNT10B(1), WNT16(2), WNT2(3), WNT3A(1), WNT4(1), WNT5B(1), WNT6(2), WNT7A(2), WNT7B(1), WNT8A(2), WNT8B(1), WNT9B(1)	32695810	382	141	346	131	78	82	37	120	62	3	0.912	1.000	1.000
158	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(2), AKT3(4), BCAR1(3), CAPN1(3), CAPN10(1), CAPN11(11), CAPN2(1), CAPN3(5), CAPN5(4), CAPN6(1), CAPN7(4), CAPN9(3), CAPNS1(1), CAV1(1), CAV2(3), CDC42(2), CSK(2), DOCK1(14), FYN(2), GIT2(3), ILK(1), ITGA10(10), ITGA11(10), ITGA2(7), ITGA2B(5), ITGA3(5), ITGA4(7), ITGA5(4), ITGA6(3), ITGA7(8), ITGA8(6), ITGA9(8), ITGAD(12), ITGAE(7), ITGAL(7), ITGAM(7), ITGAV(9), ITGAX(7), ITGB1(3), ITGB2(9), ITGB3(3), ITGB4(9), ITGB5(7), ITGB6(5), ITGB7(2), ITGB8(9), MAP2K1(5), MAP2K2(3), MAP2K6(1), MAPK10(4), MAPK12(2), MAPK4(5), MAPK6(7), MAPK7(6), MYLK2(4), PAK1(4), PAK2(8), PAK3(6), PAK4(3), PAK6(4), PDPK1(2), PIK3R2(4), PTK2(9), PXN(5), RAC1(1), RAC2(4), RAPGEF1(7), RHO(2), ROCK1(7), ROCK2(8), SDCCAG8(6), SEPP1(3), SHC1(5), SORBS1(5), SOS1(10), SRC(2), TLN1(12), TNS1(14), VASP(3), VAV2(2), VAV3(7), VCL(4), ZYX(2)	41469707	426	141	420	173	113	101	41	100	70	1	0.992	1.000	1.000
159	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(5), ACTB(1), ACTG1(1), ACTN1(5), ACTN2(8), ACTN3(1), ACTN4(2), ACVR1B(3), ACVR1C(1), BAIAP2(3), CDC42(2), CDH1(4), CREBBP(12), CSNK2A1(2), CSNK2A2(1), CTNNA1(1), CTNNA2(10), CTNNA3(3), CTNNB1(59), CTNND1(3), EGFR(7), EP300(7), ERBB2(4), FARP2(7), FER(4), FGFR1(2), FYN(2), IGF1R(12), INSR(11), IQGAP1(10), LEF1(4), LMO7(11), MAP3K7(3), MAPK1(3), MAPK3(1), MET(2), MLLT4(7), NLK(3), PARD3(5), PTPN1(2), PTPN6(2), PTPRB(14), PTPRF(4), PTPRJ(4), PTPRM(16), PVRL1(2), PVRL2(4), PVRL3(3), RAC1(1), RAC2(4), SMAD2(3), SMAD3(5), SNAI1(3), SNAI2(1), SORBS1(5), SRC(2), SSX2IP(4), TCF7(5), TCF7L1(5), TCF7L2(6), TGFBR1(5), TGFBR2(1), TJP1(9), VCL(4), WAS(2), WASF1(2), WASF2(2), WASF3(4), WASL(2), YES1(4)	36323229	362	139	330	160	78	85	41	107	50	1	0.996	1.000	1.000
160	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA1(3), ADORA2A(2), ADORA2B(4), ADORA3(3), ADRA1A(3), ADRA1B(2), ADRA1D(3), ADRA2A(1), ADRA2C(1), ADRB1(1), ADRB2(5), ADRB3(1), AGTR1(3), AVPR1B(2), BDKRB1(2), BDKRB2(4), BRS3(2), C3AR1(2), CCKBR(4), CCR1(3), CCR2(4), CCR3(3), CCR5(2), CCR6(4), CCR7(4), CCR8(1), CCR9(2), CCRL2(2), CHML(3), CHRM2(5), CHRM3(4), CHRM4(1), CHRM5(3), CMKLR1(2), CNR1(3), CNR2(1), CX3CR1(4), CXCR3(1), CXCR4(2), DRD2(2), DRD3(5), DRD5(8), EDNRA(3), EDNRB(2), F2R(2), F2RL1(1), F2RL3(1), FPR1(2), FSHR(2), GALR1(2), GALT(1), GHSR(2), GNB2L1(2), GPR17(3), GPR173(5), GPR174(4), GPR3(1), GPR35(2), GPR37(1), GPR4(2), GPR50(5), GPR63(5), GPR83(3), GPR85(4), GPR87(3), HCRTR1(3), HCRTR2(2), HRH1(1), HRH2(3), HRH3(2), HTR1A(1), HTR1B(1), HTR1D(2), HTR1E(2), HTR1F(3), HTR2A(2), HTR2B(4), HTR2C(7), HTR4(1), HTR5A(1), HTR6(4), HTR7(10), LHCGR(7), LTB4R(1), MC1R(1), MC3R(2), MC4R(2), MC5R(5), MTNR1A(5), NMBR(3), NMUR1(2), NMUR2(8), NPY1R(4), NPY2R(4), NPY5R(4), OPN3(1), OPRK1(2), OPRL1(1), OPRM1(10), OR10A5(5), OR11A1(2), OR12D3(4), OR1C1(6), OR1F1(1), OR1Q1(1), OR2H1(2), OR5V1(3), OR7A5(1), OR7C1(7), OR8B8(3), OXTR(2), P2RY1(5), P2RY10(1), P2RY12(4), P2RY13(2), P2RY2(2), P2RY6(1), PPYR1(2), PTGDR(1), PTGER2(5), PTGER4(1), PTGFR(3), PTGIR(2), RGR(1), RHO(2), RRH(3), SSTR2(2), SSTR3(6), SSTR4(2), SUCNR1(1), TRHR(5)	35558804	374	136	360	188	90	72	31	149	32	0	1.000	1.000	1.000
161	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(1), ADCY1(7), ADCY2(10), ADCY3(7), ADCY4(6), ADCY5(5), ADCY6(9), ADCY7(3), ADCY8(12), ADCY9(9), ADK(3), ADSL(1), ADSS(3), ADSSL1(2), AK2(1), AK5(1), AK7(9), ALLC(5), AMPD1(7), AMPD2(4), AMPD3(4), ATIC(1), ENPP1(4), ENPP3(8), ENTPD1(6), ENTPD2(2), ENTPD3(1), ENTPD4(2), ENTPD5(4), ENTPD6(4), GART(10), GDA(2), GMPR(1), GMPR2(3), GMPS(3), GUCY1A2(5), GUCY1A3(3), GUCY1B3(7), GUCY2C(6), GUCY2D(3), GUCY2F(9), GUK1(4), HPRT1(1), IMPDH1(2), IMPDH2(3), NME1(1), NME4(1), NME6(1), NPR1(3), NPR2(6), NT5C(1), NT5C1A(2), NT5C1B(2), NT5C2(6), NUDT5(1), PAICS(2), PAPSS1(4), PAPSS2(5), PDE10A(9), PDE11A(8), PDE1A(2), PDE1C(11), PDE2A(6), PDE3B(9), PDE4A(9), PDE4B(3), PDE4C(2), PDE4D(8), PDE5A(5), PDE7A(5), PDE7B(1), PDE8A(8), PDE8B(3), PDE9A(3), PFAS(7), PKLR(1), PNPT1(4), POLA1(10), POLA2(1), POLD1(5), POLD3(1), POLE(9), POLE2(7), POLE3(2), POLR1A(10), POLR1B(3), POLR1C(1), POLR1D(1), POLR2A(10), POLR2B(8), POLR2C(1), POLR2E(2), POLR2G(2), POLR2H(1), POLR2I(2), POLR3A(9), POLR3B(4), POLR3K(1), PPAT(3), PRIM1(2), PRIM2(2), PRPS1(1), PRPS1L1(2), PRPS2(3), RFC5(3), RRM1(5), RRM2(2), XDH(13), ZNRD1(1)	49625982	469	135	467	228	116	119	38	126	67	3	1.000	1.000	1.000
162	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	57	ASH1L(11), ASH2L(2), CARM1(2), CTCFL(4), DOT1L(9), EED(4), EHMT1(5), EHMT2(7), EZH1(5), EZH2(3), FBXO11(9), HCFC1(5), HSF4(3), JMJD6(1), KDM6A(4), MEN1(3), MLL(19), MLL2(26), MLL3(38), MLL4(20), MLL5(10), NSD1(14), OGT(4), PAXIP1(3), PPP1CA(3), PPP1CB(3), PPP1CC(1), PRDM2(13), PRDM6(3), PRDM7(3), PRDM9(6), PRMT1(6), PRMT5(4), PRMT6(4), PRMT7(1), PRMT8(3), RBBP5(3), SATB1(11), SETD1A(7), SETD1B(3), SETD2(11), SETD7(3), SETD8(2), SETDB1(5), SETDB2(8), SETMAR(2), SMYD3(2), SUV39H1(1), SUV39H2(3), SUV420H1(6), SUV420H2(1), SUZ12(3), WHSC1(4), WHSC1L1(13)	38056612	349	134	340	147	68	69	36	100	69	7	0.992	1.000	1.000
163	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(15), CCNA1(2), CCNB1(4), CCND1(1), CCND2(1), CCNE1(2), CCNE2(3), CCNG2(1), CCNH(3), CDC25A(2), CDK7(1), CDKN1A(6), CDKN1B(2), CDKN2A(3), CDKN2C(1), CREB3(2), CREB3L1(5), CREB3L3(4), CREB3L4(3), E2F1(2), E2F3(2), E2F4(2), E2F5(3), E2F6(3), GADD45A(1), MCM2(5), MCM3(3), MCM4(4), MCM5(3), MCM6(4), MCM7(6), MDM2(2), MNAT1(1), MYC(2), MYT1(6), NACA(6), POLA2(1), POLE(9), POLE2(7), PRIM1(2), RB1(19), RBL1(6), RPA1(5), RPA2(2), RPA3(1), TFDP1(3), TFDP2(5), TNXB(23), TP53(67), WEE1(4)	23284722	270	134	255	74	46	52	26	86	58	2	0.100	1.000	1.000
164	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(7), ADCY2(10), ADCY3(7), ADCY4(6), ADCY5(5), ADCY6(9), ADCY7(3), ADCY8(12), ADCY9(9), ATF4(6), CACNA1C(8), CACNA1D(9), CACNA1F(7), CACNA1S(7), CALM1(1), CALML6(1), CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), CDC42(2), EGFR(7), GNAS(9), GNRH1(1), GNRH2(1), GNRHR(2), HBEGF(1), ITPR1(18), ITPR2(19), ITPR3(15), JUN(1), KRAS(4), LHB(3), MAP2K1(5), MAP2K2(3), MAP2K4(4), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K2(1), MAP3K3(2), MAP3K4(9), MAPK1(3), MAPK10(4), MAPK11(4), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(1), MAPK7(6), MAPK9(4), MMP14(4), MMP2(1), NRAS(1), PLA2G12A(2), PLA2G12B(2), PLA2G1B(1), PLA2G2A(1), PLA2G2D(3), PLA2G2E(1), PLA2G2F(6), PLA2G3(4), PLA2G4A(6), PLA2G6(6), PLCB1(11), PLCB2(4), PLCB3(5), PLCB4(16), PLD1(6), PLD2(5), PRKACA(2), PRKACB(3), PRKACG(1), PRKCA(2), PRKCD(4), PRKX(4), PTK2B(8), RAF1(2), SOS1(10), SOS2(8), SRC(2)	39502780	396	134	391	160	105	78	40	110	58	5	0.997	1.000	1.000
165	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(1), ABL2(3), AKT1(2), AKT2(7), AKT3(4), ARAF(4), BRAF(2), CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), CBL(8), CBLB(4), CDKN1A(6), CDKN1B(2), EGF(10), EGFR(7), EIF4EBP1(1), ERBB2(4), ERBB3(10), ERBB4(9), GAB1(5), GSK3B(6), HBEGF(1), JUN(1), KRAS(4), MAP2K1(5), MAP2K2(3), MAP2K4(4), MAP2K7(2), MAPK1(3), MAPK10(4), MAPK3(1), MAPK9(4), MYC(2), NCK1(1), NCK2(2), NRAS(1), NRG1(7), NRG2(3), NRG3(7), NRG4(2), PAK1(4), PAK2(8), PAK3(6), PAK4(3), PAK6(4), PAK7(9), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PLCG1(10), PLCG2(16), PRKCA(2), PRKCG(2), PTK2(9), RAF1(2), RPS6KB1(5), RPS6KB2(3), SHC1(5), SHC2(1), SHC4(5), SOS1(10), SOS2(8), SRC(2), STAT5A(2), STAT5B(3), TGFA(1)	31228272	332	133	330	116	75	91	29	85	50	2	0.727	1.000	1.000
166	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	91	ADCY1(7), ADCY2(10), ADCY3(7), ADCY4(6), ADCY5(5), ADCY6(9), ADCY7(3), ADCY8(12), ADCY9(9), AKAP1(4), AKAP11(12), AKAP12(8), AKAP3(8), AKAP4(9), AKAP5(3), AKAP6(18), AKAP7(3), AKAP8(3), AKAP9(22), ARHGEF1(3), CALM1(1), CHMP1B(1), GNA12(1), GNA13(2), GNA14(1), GNA15(2), GNAI2(2), GNAI3(1), GNAL(4), GNAO1(2), GNB1(4), GNB2(2), GNB5(6), GNG12(1), GNG5(1), GNGT1(1), IL18BP(1), ITPR1(18), KCNJ3(1), KRAS(4), NRAS(1), PALM2(1), PDE1A(2), PDE1B(3), PDE1C(11), PDE4A(9), PDE4B(3), PDE4C(2), PDE4D(8), PDE7A(5), PDE7B(1), PDE8A(8), PDE8B(3), PLCB3(5), PPP3CA(6), PPP3CC(1), PRKACA(2), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(2), PRKCD(4), PRKCG(2), PRKCH(2), PRKCI(1), PRKCQ(2), PRKCZ(3), PRKD1(7), PRKD3(2), SLC9A1(1), USP5(6)	35080652	329	131	326	147	73	84	36	92	42	2	0.998	1.000	1.000
167	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(1), ACTN1(5), ACTR2(2), ACTR3(3), AKT1(2), AKT2(7), AKT3(4), ARHGEF6(4), ARHGEF7(6), BCAR1(3), BRAF(2), CAV1(1), CDC42(2), CDKN2A(3), CSE1L(4), DOCK1(14), EPHB2(7), FYN(2), GRB7(2), ILK(1), ITGA1(7), ITGA10(10), ITGA11(10), ITGA2(7), ITGA3(5), ITGA4(7), ITGA5(4), ITGA6(3), ITGA7(8), ITGA8(6), ITGA9(8), ITGB3BP(3), MAP2K4(4), MAP2K7(2), MAP3K11(3), MAPK1(3), MAPK10(4), MAPK8IP3(2), MAPK9(4), MRAS(1), MYLK(4), MYLK2(4), P4HB(1), PAK1(4), PAK2(8), PAK3(6), PAK4(3), PAK6(4), PAK7(9), PIK3CA(10), PIK3CB(12), PKLR(1), PLCG1(10), PLCG2(16), PTEN(11), PTK2(9), RAF1(2), RALA(2), RHO(2), ROCK1(7), ROCK2(8), SHC1(5), SOS1(10), SOS2(8), SRC(2), TERF2IP(1), TLN1(12), TLN2(11), VASP(3), WAS(2), ZYX(2)	37150798	365	131	361	131	72	101	35	95	60	2	0.861	1.000	1.000
168	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	65	APAF1(10), ATM(15), ATR(14), BAI1(5), BAX(1), BID(2), CASP3(2), CASP8(3), CASP9(1), CCNB1(4), CCNB2(2), CCNB3(8), CCND1(1), CCND2(1), CCNE1(2), CCNE2(3), CCNG1(1), CCNG2(1), CD82(2), CDK6(2), CDKN1A(6), CDKN2A(3), CHEK1(7), CHEK2(6), DDB2(4), EI24(7), FAS(5), GADD45A(1), GTSE1(4), IGF1(1), IGFBP3(1), MDM2(2), MDM4(4), PERP(2), PTEN(11), RCHY1(1), RFWD2(2), RPRM(1), RRM2(2), SERPINB5(2), SERPINE1(4), SESN1(6), SESN2(5), SESN3(4), SFN(1), SIAH1(6), STEAP3(2), THBS1(3), TNFRSF10B(2), TP53(67), TP73(1), TSC2(15), ZMAT3(2)	19722194	270	130	256	70	52	42	28	87	59	2	0.106	1.000	1.000
169	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(2), ACTA2(1), ACTN2(8), ACTN3(1), ACTN4(2), DES(2), DMD(33), MYBPC1(9), MYBPC2(5), MYBPC3(6), MYH3(13), MYH6(10), MYH7(16), MYH8(10), MYL1(1), MYL9(1), MYOM1(14), NEB(36), TCAP(1), TMOD1(3), TNNC2(2), TNNI1(1), TNNI2(2), TNNT2(2), TNNT3(2), TPM1(4), TPM2(5), TPM3(3), TPM4(2), TTN(182), VIM(6)	42590329	385	130	381	186	82	96	52	119	32	4	0.999	1.000	1.000
170	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM1(1), CALML6(1), CDIPT(1), CDS1(1), CDS2(1), DGKA(5), DGKB(2), DGKD(4), DGKE(4), DGKG(6), DGKH(4), DGKI(4), DGKZ(7), FN3K(1), IMPA1(3), IMPA2(3), INPP1(3), INPP4A(2), INPP4B(4), INPP5A(6), INPP5B(5), INPP5D(3), INPP5E(1), INPPL1(3), ITPK1(2), ITPKA(1), ITPKB(2), ITPR1(18), ITPR2(19), ITPR3(15), OCRL(5), PI4KA(5), PI4KB(1), PIK3C2A(8), PIK3C2B(9), PIK3C2G(11), PIK3C3(2), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PIP4K2A(2), PIP4K2B(3), PIP4K2C(4), PIP5K1B(2), PIP5K1C(3), PLCB1(11), PLCB2(4), PLCB3(5), PLCB4(16), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(14), PLCG1(10), PLCG2(16), PLCZ1(2), PRKCA(2), PRKCG(2), PTEN(11), SYNJ1(10), SYNJ2(2)	38307861	344	129	340	181	83	80	37	88	54	2	1.000	1.000	1.000
171	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(1), ADCY1(7), ADCY2(10), ADCY3(7), ADCY4(6), ADCY5(5), ADCY6(9), ADCY7(3), ADCY8(12), ADK(3), ADSL(1), ADSS(3), AK2(1), AK5(1), ALLC(5), AMPD1(7), AMPD2(4), AMPD3(4), ATIC(1), ATP1B1(2), ATP5A1(3), ATP5B(3), ATP5C1(2), ATP5D(1), ATP5F1(1), ATP5G1(1), ATP5G2(1), ATP5G3(2), ATP5H(1), ENPP1(4), ENPP3(8), ENTPD1(6), ENTPD2(2), GART(10), GDA(2), GMPS(3), GUCY1A2(5), GUCY1A3(3), GUCY1B3(7), GUCY2C(6), GUCY2D(3), GUCY2F(9), GUK1(4), HPRT1(1), IMPDH1(2), IMPDH2(3), NME1(1), NPR1(3), NPR2(6), NT5C(1), PAICS(2), PAPSS1(4), PAPSS2(5), PDE1A(2), PDE4A(9), PDE4B(3), PDE4C(2), PDE4D(8), PDE5A(5), PDE6B(7), PDE6C(5), PDE7B(1), PDE8A(8), PDE9A(3), PFAS(7), PKLR(1), POLB(4), POLD1(5), POLE(9), POLG(7), POLL(1), POLQ(18), POLR1B(3), POLR2A(10), POLR2B(8), POLR2C(1), POLR2E(2), POLR2G(2), POLR2H(1), POLR2I(2), POLRMT(1), PPAT(3), PRPS1(1), PRPS1L1(2), PRPS2(3), RRM1(5), RRM2(2)	38834317	358	129	358	170	86	96	25	107	44	0	1.000	1.000	1.000
172	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(7), ADCY8(12), ARAF(4), ATF4(6), BRAF(2), CACNA1C(8), CALM1(1), CALML6(1), CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(1), CREBBP(12), EP300(7), GRIA1(8), GRIA2(10), GRIN1(6), GRIN2A(6), GRIN2B(10), GRIN2C(4), GRIN2D(4), GRM1(8), GRM5(5), ITPR1(18), ITPR2(19), ITPR3(15), KRAS(4), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), NRAS(1), PLCB1(11), PLCB2(4), PLCB3(5), PLCB4(16), PPP1CA(3), PPP1CB(3), PPP1CC(1), PPP1R12A(8), PPP1R1A(2), PPP3CA(6), PPP3CB(5), PPP3CC(1), PPP3R1(1), PRKACA(2), PRKACB(3), PRKACG(1), PRKCA(2), PRKCG(2), PRKX(4), RAF1(2), RAP1A(2), RAPGEF3(4), RPS6KA1(4), RPS6KA2(6), RPS6KA3(10), RPS6KA6(9)	30872097	321	128	319	136	74	78	32	92	42	3	0.995	1.000	1.000
173	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(4), ACVR1B(3), ACVRL1(4), AKT1(2), AURKB(2), BMPR1A(1), BMPR2(8), BUB1(6), CDIPT(1), CDKL1(1), CDKL2(4), CDS1(1), CDS2(1), CLK1(3), CLK2(2), CLK4(5), COL4A3BP(2), CSNK2A1(2), CSNK2A2(1), DGKA(5), DGKB(2), DGKD(4), DGKE(4), DGKG(6), DGKH(4), DGKZ(7), IMPA1(3), INPP1(3), INPP4A(2), INPP4B(4), INPP5A(6), INPPL1(3), ITPKA(1), ITPKB(2), MAP3K10(1), MOS(1), NEK1(9), NEK3(2), OCRL(5), PAK4(3), PIK3C2A(8), PIK3C2B(9), PIK3C2G(11), PIK3CA(10), PIK3CB(12), PIK3CG(4), PIM2(1), PLCB1(11), PLCB2(4), PLCB3(5), PLCB4(16), PLCD1(1), PLCG1(10), PLCG2(16), PLK3(3), PRKACA(2), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(2), PRKCD(4), PRKCG(2), PRKCH(2), PRKCQ(2), PRKCZ(3), PRKD1(7), PRKG1(5), RAF1(2), RPS6KA1(4), RPS6KA2(6), RPS6KA3(10), RPS6KA4(1), RPS6KB1(5), STK11(1), TGFBR1(5), VRK1(4)	34650109	327	126	324	178	66	85	41	79	55	1	1.000	1.000	1.000
174	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	93	AKT1(2), AKT2(7), AKT3(4), BCL10(1), CARD11(15), CBL(8), CBLB(4), CD247(1), CD4(3), CD8A(1), CD8B(4), CDC42(2), CHUK(9), CSF2(2), CTLA4(3), FOS(2), FYN(2), GRAP2(3), IFNG(3), IKBKB(6), IL2(1), IL4(1), ITK(2), JUN(1), KRAS(4), LCK(5), LCP2(4), MALT1(6), MAP3K14(2), MAP3K8(2), NCK1(1), NCK2(2), NFAT5(13), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), NFKB1(7), NFKB2(2), NFKBIA(2), NFKBIE(1), NRAS(1), PAK1(4), PAK2(8), PAK3(6), PAK4(3), PAK6(4), PAK7(9), PDCD1(2), PDK1(1), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PLCG1(10), PPP3CA(6), PPP3CB(5), PPP3CC(1), PPP3R1(1), PRKCQ(2), PTPN6(2), PTPRC(9), RASGRP1(9), SOS1(10), SOS2(8), TEC(2), TNF(2), VAV1(6), VAV2(2), VAV3(7), ZAP70(3)	30606686	324	124	321	124	78	75	36	90	44	1	0.907	1.000	1.000
175	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	ALG2(6), BAX(1), BFAR(1), BTK(1), CAD(7), CASP10(4), CASP3(2), CASP8(3), CASP8AP2(6), CSNK1A1(1), DAXX(1), DEDD2(4), DFFA(2), DIABLO(3), EGFR(7), EPHB2(7), FADD(2), FAF1(6), FAIM2(1), IL1A(3), MAP2K4(4), MAP2K7(2), MAP3K1(6), MAP3K5(6), MAPK1(3), MAPK10(4), MAPK8IP3(2), MAPK9(4), MET(2), NFAT5(13), NFKB1(7), NFKB2(2), NFKBIA(2), NFKBIE(1), NFKBIL1(3), NR0B2(3), PTPN13(21), RALBP1(1), RIPK1(6), ROCK1(7), SMPD1(3), TNFRSF6B(2), TP53(67), TPX2(4)	22457631	243	124	228	73	47	49	25	73	49	0	0.335	1.000	1.000
176	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	83	AGL(9), AMY2A(5), AMY2B(2), ASCC3(15), ATP13A2(8), DDX18(4), DDX19A(2), DDX23(4), DDX4(3), DDX41(3), DDX47(2), DDX50(4), DDX51(4), DDX52(5), DDX54(4), DDX55(4), DDX56(1), DHX58(6), ENPP1(4), ENPP3(8), ENTPD7(4), EP400(12), ERCC2(5), ERCC3(4), G6PC(4), G6PC2(4), GAA(2), GANC(3), GBA(1), GBE1(1), GCK(3), GPI(2), GUSB(6), GYS1(2), GYS2(5), HK1(4), HK2(8), HK3(6), IFIH1(5), LYZL1(3), MGAM(18), MOV10L1(2), NUDT5(1), PGM1(3), PGM3(6), PYGB(1), PYGL(8), PYGM(9), RAD54B(5), RAD54L(2), RUVBL2(1), SETX(20), SI(14), SKIV2L2(4), SMARCA2(11), SMARCA5(2), TREH(5), UGDH(4), UGP2(2), UGT1A1(1), UGT1A10(3), UGT1A3(2), UGT1A4(1), UGT1A5(13), UGT1A8(1), UGT1A9(1), UGT2A1(5), UGT2A3(3), UGT2B10(2), UGT2B11(3), UGT2B15(5), UGT2B17(1), UGT2B28(13), UGT2B4(5), UGT2B7(5)	40049189	363	123	353	198	75	90	45	98	51	4	1.000	1.000	1.000
177	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(2), AKT2(7), AKT3(4), CASP9(1), CDC42(2), KDR(13), KRAS(4), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK11(4), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(1), MAPKAPK2(4), MAPKAPK3(1), NFAT5(13), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), NOS3(8), NRAS(1), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PLA2G12A(2), PLA2G12B(2), PLA2G1B(1), PLA2G2A(1), PLA2G2D(3), PLA2G2E(1), PLA2G2F(6), PLA2G3(4), PLA2G4A(6), PLA2G6(6), PLCG1(10), PLCG2(16), PPP3CA(6), PPP3CB(5), PPP3CC(1), PPP3R1(1), PRKCA(2), PRKCG(2), PTGS2(2), PTK2(9), PXN(5), RAC1(1), RAC2(4), RAF1(2), SH2D2A(4), SHC2(1), SPHK1(6), SPHK2(4), SRC(2)	21830257	261	123	255	77	66	65	29	64	37	0	0.234	1.000	1.000
178	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(19), ABCA10(11), ABCA12(16), ABCA13(54), ABCA2(8), ABCA3(7), ABCA4(18), ABCA5(5), ABCA6(11), ABCA7(12), ABCA8(7), ABCA9(8), ABCB1(11), ABCB10(2), ABCB11(8), ABCB4(6), ABCB5(16), ABCB6(7), ABCB7(4), ABCB8(3), ABCB9(3), ABCC1(7), ABCC10(5), ABCC11(4), ABCC12(3), ABCC2(6), ABCC3(10), ABCC4(9), ABCC5(8), ABCC6(3), ABCC8(11), ABCC9(13), ABCD1(1), ABCD2(3), ABCD3(1), ABCD4(4), ABCG1(1), ABCG2(5), ABCG4(3), ABCG5(2), ABCG8(3), CFTR(12), TAP1(3), TAP2(2)	36220409	355	122	352	166	74	82	37	117	44	1	1.000	1.000	1.000
179	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	99	AKT1(2), AKT2(7), AKT3(4), CASP8(3), CCL3(1), CD40(4), CD80(1), CD86(4), CHUK(9), FADD(2), FOS(2), IFNA13(1), IFNA14(2), IFNA16(2), IFNA17(6), IFNA2(2), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(5), IFNA8(2), IFNAR1(5), IFNAR2(1), IFNB1(1), IKBKB(6), IKBKE(2), IL12A(6), IL12B(2), IL1B(2), IL6(3), IRAK1(6), IRAK4(9), IRF3(2), JUN(1), LBP(5), LY96(1), MAP2K1(5), MAP2K2(3), MAP2K4(4), MAP2K6(1), MAP2K7(2), MAP3K7(3), MAP3K8(2), MAPK1(3), MAPK10(4), MAPK11(4), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(1), MAPK9(4), MYD88(3), NFKB1(7), NFKB2(2), NFKBIA(2), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), RAC1(1), RELA(4), RIPK1(6), SPP1(1), STAT1(7), TBK1(5), TICAM1(4), TIRAP(2), TLR1(8), TLR2(2), TLR3(4), TLR4(3), TLR5(3), TLR6(6), TLR7(7), TLR8(8), TLR9(3), TNF(2), TOLLIP(1), TRAF3(1), TRAF6(1)	27006534	300	122	293	132	64	62	45	84	45	0	0.997	1.000	1.000
180	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	A4GNT(2), ALG1(1), ALG10B(3), ALG11(2), ALG12(1), ALG13(9), ALG2(6), ALG3(1), ALG6(5), ALG8(1), ALG9(4), B3GNT2(2), B3GNT7(1), B4GALT2(2), B4GALT3(2), B4GALT4(1), B4GALT5(2), C1GALT1C1(1), CHPF(9), CHST1(2), CHST11(1), CHST12(3), CHST13(2), CHST14(2), CHST2(4), CHST3(5), CHST4(1), CHST6(2), CHST7(1), CHSY1(2), DDOST(1), DPAGT1(3), EXT1(2), EXT2(3), EXTL1(5), EXTL2(1), EXTL3(4), FUT11(4), FUT8(2), GALNT1(4), GALNT11(3), GALNT12(3), GALNT13(7), GALNT14(3), GALNT3(3), GALNT4(7), GALNT5(6), GALNT6(4), GALNT8(6), GALNT9(3), GALNTL5(4), GANAB(5), GCNT3(4), GCNT4(2), HS2ST1(3), HS3ST1(1), HS3ST2(1), HS3ST3A1(3), HS3ST5(3), HS6ST1(1), HS6ST2(1), HS6ST3(4), MAN1A1(3), MAN1A2(4), MAN1B1(1), MAN1C1(5), MAN2A1(7), MGAT1(3), MGAT2(2), MGAT3(8), MGAT4A(2), MGAT5(5), MGAT5B(5), NDST1(3), NDST2(3), NDST3(5), NDST4(7), OGT(4), RPN1(2), RPN2(2), ST3GAL1(1), ST3GAL3(4), ST3GAL4(1), ST6GAL1(2), ST6GALNAC1(6), STT3B(3), UST(3), WBSCR17(7), XYLT1(7), XYLT2(3)	32971748	294	121	290	134	71	69	36	79	37	2	0.997	1.000	1.000
181	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	67	APAF1(10), BAX(1), BCL2(1), BCL2L11(1), BID(2), BIRC2(6), BIRC3(6), CASP1(4), CASP10(4), CASP2(1), CASP3(2), CASP4(4), CASP6(2), CASP7(4), CASP8(3), CASP9(1), CHUK(9), DFFA(2), DFFB(3), FADD(2), FAS(5), FASLG(2), GZMB(1), HELLS(10), IKBKB(6), IRF1(1), IRF2(3), IRF3(2), IRF4(4), IRF6(4), JUN(1), LTA(2), MAP2K4(4), MAP3K1(6), MAPK10(4), MDM2(2), MYC(2), NFKB1(7), NFKBIA(2), NFKBIE(1), PLEKHG5(4), PRF1(4), RELA(4), RIPK1(6), TNF(2), TNFRSF10B(2), TNFRSF1A(2), TNFRSF1B(3), TNFRSF21(6), TNFRSF25(3), TNFSF10(2), TP53(67), TP73(1), TRAF1(3), TRAF3(1)	17481033	247	120	233	75	49	44	26	73	55	0	0.461	1.000	1.000
182	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	73	AKT1(2), AKT2(7), AKT3(4), BTK(1), CSF2(2), FCER1A(2), FYN(2), GAB2(3), IL3(2), IL4(1), INPP5D(3), KRAS(4), LCP2(4), LYN(3), MAP2K1(5), MAP2K2(3), MAP2K4(4), MAP2K6(1), MAP2K7(2), MAPK1(3), MAPK10(4), MAPK11(4), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(1), MAPK9(4), MS4A2(5), NRAS(1), PDK1(1), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PLA2G12A(2), PLA2G12B(2), PLA2G1B(1), PLA2G2A(1), PLA2G2D(3), PLA2G2E(1), PLA2G2F(6), PLA2G3(4), PLA2G4A(6), PLA2G6(6), PLCG1(10), PLCG2(16), PRKCA(2), PRKCD(4), RAC1(1), RAC2(4), RAF1(2), SOS1(10), SOS2(8), SYK(4), TNF(2), VAV1(6), VAV2(2), VAV3(7)	21456827	242	120	239	69	67	52	30	61	31	1	0.213	1.000	1.000
183	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	63	AKT1(2), AKT2(7), AKT3(4), BCL10(1), BLNK(3), BTK(1), CARD11(15), CD19(1), CD22(9), CD72(1), CD79A(1), CD81(1), CHUK(9), CR2(9), FCGR2B(3), FOS(2), GSK3B(6), IKBKB(6), INPP5D(3), JUN(1), KRAS(4), LILRB3(7), LYN(3), MALT1(6), NFAT5(13), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), NFKB1(7), NFKB2(2), NFKBIA(2), NFKBIE(1), NRAS(1), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PLCG2(16), PPP3CA(6), PPP3CB(5), PPP3CC(1), PPP3R1(1), PTPN6(2), RAC1(1), RAC2(4), RASGRP3(4), SYK(4), VAV1(6), VAV2(2), VAV3(7)	22503896	253	117	250	91	65	52	38	66	32	0	0.683	1.000	1.000
184	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(1), APAF1(10), ARHGDIB(1), BAG4(5), BCL2(1), BID(2), BIRC2(6), BIRC3(6), CASP2(1), CASP3(2), CASP6(2), CASP7(4), CASP8(3), CASP9(1), CFLAR(2), CHUK(9), CRADD(1), DAXX(1), DFFA(2), DFFB(3), FADD(2), GSN(2), LMNA(3), LMNB1(5), LMNB2(4), MAP2K7(2), MAP3K1(6), MAP3K14(2), MAP3K5(6), MDM2(2), NFKB1(7), NFKBIA(2), NUMA1(9), PAK2(8), PRKCD(4), PRKDC(26), PSEN1(2), PTK2(9), RASA1(10), RB1(19), RELA(4), RIPK1(6), SPTAN1(9), TNF(2), TNFRSF1A(2), TNFRSF1B(3), TRAF1(3)	21155182	222	116	220	83	38	48	16	64	55	1	0.940	1.000	1.000
185	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1(4), ACVR1B(3), ACVR1C(1), ACVR2A(11), ACVR2B(4), ACVRL1(4), AMH(1), AMHR2(1), BMP2(3), BMP4(1), BMP5(3), BMP7(3), BMPR1A(1), BMPR1B(2), BMPR2(8), CHRD(2), COMP(2), CREBBP(12), CUL1(3), DCN(2), E2F4(2), E2F5(3), EP300(7), FST(3), GDF5(4), ID1(1), IFNG(3), INHBA(2), INHBC(3), INHBE(1), LEFTY1(2), LEFTY2(1), LTBP1(9), MAPK1(3), MAPK3(1), MYC(2), NOG(1), PITX2(1), PPP2CA(4), PPP2CB(3), PPP2R1A(4), PPP2R1B(3), PPP2R2B(3), PPP2R2C(4), RBL1(6), RBL2(8), ROCK1(7), ROCK2(8), RPS6KB1(5), RPS6KB2(3), SMAD1(1), SMAD2(3), SMAD3(5), SMAD5(2), SMAD6(1), SMAD7(3), SMAD9(4), SMURF1(4), SMURF2(3), SP1(2), TFDP1(3), TGFB1(1), TGFB2(4), TGFB3(3), TGFBR1(5), TGFBR2(1), THBS1(3), THBS2(5), THBS3(5), THBS4(3), TNF(2), ZFYVE16(10), ZFYVE9(10)	29623889	261	116	260	123	54	66	33	63	42	3	0.999	1.000	1.000
186	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	85	ATF2(1), BRAF(2), CHUK(9), CREB1(1), DAXX(1), FOS(2), IKBKB(6), JUN(1), MAP2K1(5), MAP2K2(3), MAP2K4(4), MAP2K5(1), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K10(1), MAP3K11(3), MAP3K12(2), MAP3K13(3), MAP3K14(2), MAP3K2(1), MAP3K3(2), MAP3K4(9), MAP3K5(6), MAP3K6(8), MAP3K7(3), MAP3K8(2), MAP3K9(5), MAP4K1(5), MAP4K2(4), MAP4K3(6), MAP4K4(9), MAP4K5(11), MAPK1(3), MAPK10(4), MAPK11(4), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(1), MAPK4(5), MAPK6(7), MAPK7(6), MAPK9(4), MAPKAPK2(4), MAPKAPK3(1), MAPKAPK5(4), MEF2A(4), MEF2C(3), MEF2D(1), MKNK1(2), MKNK2(1), MYC(2), NFKB1(7), NFKBIA(2), PAK1(4), PAK2(8), RAC1(1), RAF1(2), RELA(4), RIPK1(6), RPS6KA1(4), RPS6KA2(6), RPS6KA3(10), RPS6KA4(1), RPS6KA5(3), RPS6KB1(5), RPS6KB2(3), SHC1(5), SP1(2), STAT1(7), TGFB1(1), TGFB2(4), TGFB3(3), TGFBR1(5)	29705913	283	116	278	120	65	67	34	68	48	1	0.984	1.000	1.000
187	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	68	A2M(9), BDKRB1(2), BDKRB2(4), C1QA(2), C1QC(1), C1R(1), C1S(4), C2(9), C3(12), C3AR1(2), C4A(2), C4BPA(1), C5(9), C5AR1(1), C6(2), C7(3), C8A(3), C8B(7), C9(3), CD46(3), CD55(4), CD59(1), CFB(2), CFH(14), CFI(3), CPB2(3), CR1(23), CR2(9), F10(3), F13A1(4), F13B(2), F2(2), F2R(2), F3(2), F5(18), F8(11), F9(1), FGA(9), FGB(2), FGG(4), KLKB1(7), KNG1(5), MASP1(4), MASP2(4), MBL2(1), PLAT(2), PLAU(6), PLAUR(2), PLG(1), PROC(5), PROS1(4), SERPINA1(4), SERPINA5(3), SERPINC1(4), SERPIND1(2), SERPINE1(4), SERPINF2(1), SERPING1(1), TFPI(4), THBD(2), VWF(10)	31869726	275	115	267	131	51	66	41	73	44	0	0.997	1.000	1.000
188	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	71	ACACB(14), ACSL1(3), ACSL3(3), ACSL4(2), ACSL5(3), ACSL6(2), ADIPOR1(4), ADIPOR2(2), AKT1(2), AKT2(7), AKT3(4), CAMKK1(3), CAMKK2(3), CD36(1), CHUK(9), CPT1A(6), CPT1B(4), CPT1C(3), CPT2(1), G6PC(4), G6PC2(4), IKBKB(6), IRS1(4), IRS2(2), IRS4(9), JAK1(8), JAK2(9), JAK3(5), LEP(1), LEPR(7), MAPK10(4), MAPK9(4), NFKB1(7), NFKB2(2), NFKBIA(2), NFKBIE(1), PCK1(6), POMC(2), PPARA(4), PPARGC1A(4), PRKAA1(4), PRKAA2(4), PRKAB1(1), PRKAB2(1), PRKAG2(3), PRKAG3(2), PRKCQ(2), PTPN11(2), RELA(4), RXRA(6), RXRB(5), RXRG(2), SLC2A4(1), STAT3(5), STK11(1), TNF(2), TNFRSF1A(2), TNFRSF1B(3), TYK2(7)	25127757	228	115	228	115	48	55	24	72	29	0	1.000	1.000	1.000
189	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(2), AKT2(7), AKT3(4), BCL2(1), BCR(4), BLNK(3), BTK(1), CD19(1), CD22(9), CD81(1), CR2(9), CSK(2), FLOT1(6), FLOT2(1), GSK3A(2), GSK3B(6), INPP5D(3), ITPR1(18), ITPR2(19), ITPR3(15), LYN(3), MAP4K1(5), MAPK1(3), MAPK3(1), NFATC1(3), NFATC2(4), NR0B2(3), PDK1(1), PIK3CA(10), PIK3CD(5), PIK3R1(5), PLCG2(16), PPP1R13B(7), PPP3CA(6), PPP3CB(5), PPP3CC(1), PTPRC(9), RAF1(2), SHC1(5), SOS1(10), SOS2(8), SYK(4), VAV1(6)	22089323	236	115	234	76	60	49	30	72	23	2	0.408	1.000	1.000
190	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	31	AKT1(2), AKT2(7), AKT3(4), ANKRD6(4), APC(12), AXIN1(14), AXIN2(8), CER1(3), CSNK1A1(1), CTNNB1(59), DACT1(5), DKK1(2), DKK2(4), DKK3(3), DKK4(1), DVL1(1), FSTL1(1), GSK3A(2), GSK3B(6), LRP1(19), MVP(1), NKD1(2), NKD2(1), PIN1(1), PSEN1(2), PTPRA(5), SENP2(5), WIF1(5)	12149421	180	114	148	57	20	32	20	73	31	4	0.717	1.000	1.000
191	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(12), AXIN1(14), CCND1(1), CCND2(1), CSNK1E(3), CTNNB1(59), DVL1(1), DVL2(5), FBXW2(5), FOSL1(1), FZD1(1), FZD10(5), FZD2(3), FZD3(4), FZD5(2), FZD6(4), FZD7(1), FZD8(2), FZD9(6), GSK3B(6), JUN(1), LDLR(5), MAPK10(4), MAPK9(4), MYC(2), PAFAH1B1(1), PLAU(6), PPP2R5C(4), PPP2R5E(2), PRKCA(2), PRKCD(4), PRKCG(2), PRKCH(2), PRKCI(1), PRKCQ(2), PRKCZ(3), PRKD1(7), RAC1(1), SFRP4(3), TCF7(5), WNT1(3), WNT10B(1), WNT16(2), WNT2(3), WNT4(1), WNT5B(1), WNT6(2), WNT7A(2), WNT7B(1)	17139568	213	114	178	84	33	45	21	75	37	2	0.979	1.000	1.000
192	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(15), ATR(14), BRCA1(11), CCNB1(4), CDC25A(2), CDC25B(4), CDC25C(1), CDC34(1), CDKN1A(6), CHEK1(7), CHEK2(6), EP300(7), GADD45A(1), MDM2(2), MYT1(6), PRKDC(26), RPS6KA1(4), TP53(67), WEE1(4), YWHAH(1)	12953492	189	113	173	51	30	29	18	68	42	2	0.169	1.000	1.000
193	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(15), ATR(14), BRCA1(11), BRCA2(20), CHEK1(7), CHEK2(6), FANCA(20), FANCC(2), FANCD2(12), FANCE(2), FANCF(1), FANCG(2), HUS1(2), MRE11A(3), RAD1(2), RAD17(2), RAD50(4), RAD51(5), RAD9A(2), TP53(67), TREX1(2)	13143802	201	110	184	50	39	36	22	60	42	2	0.0339	1.000	1.000
194	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	84	ANPEP(5), CD19(1), CD1A(1), CD1B(1), CD1C(1), CD1D(3), CD1E(4), CD2(2), CD22(9), CD33(3), CD36(1), CD37(2), CD38(2), CD4(3), CD44(3), CD5(6), CD55(4), CD59(1), CD8A(1), CD8B(4), CD9(1), CR1(23), CR2(9), CSF1(1), CSF1R(3), CSF2(2), CSF2RA(4), CSF3R(1), DNTT(4), FCER2(2), FCGR1A(2), FLT3(10), FLT3LG(2), GP5(1), GYPA(2), HLA-DRB1(4), HLA-DRB5(3), IL11RA(1), IL1A(3), IL1B(2), IL1R1(4), IL1R2(2), IL2RA(2), IL3(2), IL4(1), IL4R(4), IL5RA(2), IL6(3), IL6R(1), IL7(2), IL7R(10), IL9R(5), ITGA1(7), ITGA2(7), ITGA2B(5), ITGA3(5), ITGA4(7), ITGA5(4), ITGA6(3), ITGAM(7), ITGB3(3), KIT(10), KITLG(2), MME(8), MS4A1(4), TFRC(1), THPO(1), TNF(2), TPO(11)	25372672	262	110	255	120	61	52	33	68	48	0	0.997	1.000	1.000
195	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(1), ACTB(1), ACTG1(1), ARHGEF2(6), CDC42(2), CDH1(4), CLDN1(1), CTNNB1(59), CTTN(5), EZR(5), FYN(2), ITGB1(3), KRT18(1), LY96(1), NCK1(1), NCK2(2), NCL(7), OCLN(1), PRKCA(2), ROCK1(7), ROCK2(8), TLR4(3), TLR5(3), TUBA1A(1), TUBA1C(1), TUBA3C(5), TUBA3D(3), TUBA3E(17), TUBA4A(1), TUBA8(4), TUBAL3(3), TUBB(1), TUBB1(3), TUBB2A(1), TUBB2B(1), TUBB3(1), TUBB6(1), TUBB8(3), WAS(2), WASL(2), YWHAZ(1)	15736239	177	110	133	71	23	31	24	75	23	1	0.963	1.000	1.000
196	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(1), ACTB(1), ACTG1(1), ARHGEF2(6), CDC42(2), CDH1(4), CLDN1(1), CTNNB1(59), CTTN(5), EZR(5), FYN(2), ITGB1(3), KRT18(1), LY96(1), NCK1(1), NCK2(2), NCL(7), OCLN(1), PRKCA(2), ROCK1(7), ROCK2(8), TLR4(3), TLR5(3), TUBA1A(1), TUBA1C(1), TUBA3C(5), TUBA3D(3), TUBA3E(17), TUBA4A(1), TUBA8(4), TUBAL3(3), TUBB(1), TUBB1(3), TUBB2A(1), TUBB2B(1), TUBB3(1), TUBB6(1), TUBB8(3), WAS(2), WASL(2), YWHAZ(1)	15736239	177	110	133	71	23	31	24	75	23	1	0.963	1.000	1.000
197	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	ACTB(1), BCL2(1), CABIN1(8), CALM1(1), CAMK2B(2), CAMK4(1), CD69(2), CDKN1A(6), CNR1(3), CREBBP(12), CSF2(2), CSNK2A1(2), CTLA4(3), EGR2(3), EGR3(5), EP300(7), FCER1A(2), FCGR3A(1), FOS(2), FOSL1(1), GATA3(1), GATA4(1), GSK3A(2), GSK3B(6), IFNB1(1), IFNG(3), IL1B(2), IL2(1), IL2RA(2), IL3(2), IL4(1), IL6(3), ITK(2), JUNB(2), KPNA5(2), MAP2K7(2), MAPK14(4), MAPK9(4), MEF2A(4), MEF2D(1), MYF5(1), NCK2(2), NFAT5(13), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), NFKB2(2), NFKBIE(1), NPPB(1), NUP214(9), P2RX7(3), PAK1(4), PIN1(1), PPIA(2), PPP3CB(5), PPP3CC(1), PPP3R1(1), PTPRC(9), RELA(4), SFN(1), SP1(2), SP3(3), TGFB1(1), TNF(2), TRPV6(6), VAV1(6), VAV2(2), VAV3(7), XPO5(8)	27302922	224	109	222	106	40	64	24	65	30	1	0.998	1.000	1.000
198	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(2), AKT2(7), AKT3(4), BCR(4), BTK(1), CD19(1), CDKN2A(3), DAPP1(1), FLOT1(6), FLOT2(1), GAB1(5), ITPR1(18), ITPR2(19), ITPR3(15), LYN(3), NR0B2(3), PDK1(1), PHF11(1), PIK3CA(10), PITX2(1), PLCG2(16), PPP1R13B(7), PREX1(14), PTEN(11), PTPRC(9), RPS6KA1(4), RPS6KA2(6), RPS6KA3(10), RPS6KB1(5), SAG(1), SYK(4), TEC(2), VAV1(6)	16685351	201	108	199	65	48	45	24	58	24	2	0.506	1.000	1.000
199	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	42	APAF1(10), BAX(1), BCL2(1), BID(2), BIRC2(6), BIRC3(6), CASP2(1), CASP3(2), CASP6(2), CASP7(4), CASP8(3), CASP9(1), FADD(2), FAS(5), FASLG(2), GZMB(1), JUN(1), MAP2K4(4), MAP3K1(6), MAP3K14(2), MAPK10(4), MCL1(2), MDM2(2), MYC(2), NFKB1(7), NFKBIA(2), PARP1(4), PRF1(4), RELA(4), RIPK1(6), TNF(2), TNFRSF1A(2), TNFRSF1B(3), TNFSF10(2), TP53(67), TRAF1(3)	11336581	178	107	163	44	29	33	16	55	45	0	0.126	1.000	1.000
200	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(4), APC(12), ATF2(1), AXIN1(14), BMP10(1), BMP2(3), BMP4(1), BMP5(3), BMP7(3), BMPR1A(1), BMPR2(8), CHRD(2), CTNNB1(59), DVL1(1), FZD1(1), GATA4(1), GSK3B(6), MAP3K7(3), MEF2C(3), NKX2-5(1), NOG(1), NPPA(1), NPPB(1), RFC1(7), TGFB1(1), TGFB2(4), TGFB3(3), TGFBR1(5), TGFBR2(1), TGFBR3(2), WNT1(3)	10908324	157	105	126	55	21	32	19	58	25	2	0.729	1.000	1.000
201	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT1(2), AKT2(7), AKT3(4), CDC42(2), CDKN1B(2), CDKN2A(3), CREB1(1), CREB3(2), CREB5(5), ERBB4(9), GAB1(5), GADD45A(1), GSK3A(2), GSK3B(6), IFI27(1), IGF1(1), INPPL1(3), IRS1(4), IRS2(2), IRS4(9), MET(2), MYC(2), NOLC1(5), PAK1(4), PAK2(8), PAK3(6), PAK4(3), PAK6(4), PAK7(9), PARD3(5), PDK1(1), PIK3CA(10), PIK3CD(5), PPP1R13B(7), PREX1(14), PTEN(11), PTK2(9), PTPN1(2), RPS6KA1(4), RPS6KA2(6), RPS6KA3(10), RPS6KB1(5), SFN(1), SHC1(5), SLC2A4(1), SOS1(10), SOS2(8), TSC1(13), TSC2(15), YWHAB(2), YWHAE(2), YWHAG(2), YWHAH(1), YWHAZ(1)	22844906	264	105	262	93	47	70	34	71	40	2	0.597	1.000	1.000
202	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(1), CDC40(3), CLK2(2), CLK3(3), CLK4(5), COL2A1(5), CPSF1(6), CPSF2(3), CPSF3(4), CPSF4(1), CSTF1(1), CSTF2(4), CSTF2T(1), CSTF3(3), DDIT3(1), DDX1(1), DDX20(8), DHX15(3), DHX16(7), DHX38(4), DHX8(3), DHX9(11), DICER1(13), DNAJC8(1), FUS(3), GIPC1(1), LOC440563(3), LSM7(1), METTL3(1), NCBP1(5), NONO(2), NUDT21(1), NXF1(3), PABPN1(1), PAPOLA(3), POLR2A(10), PPM1G(2), PRPF3(1), PRPF4(4), PRPF4B(4), PRPF8(12), PSKH1(2), PTBP1(4), PTBP2(4), RBM17(1), RBM5(5), RNGTT(4), RNMT(1), RNPS1(2), SF3A1(5), SF3A2(1), SF3A3(4), SF3B1(8), SF3B2(3), SF3B4(2), SNRPA(1), SNRPA1(3), SNRPB(1), SNRPB2(2), SNRPD3(1), SNRPF(1), SNRPN(2), SPOP(5), SRPK1(4), SRPK2(1), SRRM1(3), SUPT5H(5), TXNL4A(1), U2AF1(1), U2AF2(3), XRN2(4)	32006408	235	104	235	102	46	58	20	66	44	1	0.994	1.000	1.000
203	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(2), ATF2(1), CDC42(2), DLD(2), DUSP8(1), GAB1(5), GADD45A(1), GCK(3), IL1R1(4), JUN(1), MAP2K4(4), MAP2K5(1), MAP2K7(2), MAP3K1(6), MAP3K10(1), MAP3K11(3), MAP3K12(2), MAP3K13(3), MAP3K2(1), MAP3K3(2), MAP3K4(9), MAP3K5(6), MAP3K7(3), MAP3K9(5), MAPK10(4), MAPK7(6), MAPK9(4), MYEF2(4), NFATC3(4), NR2C2(4), PAPPA(9), SHC1(5), TP53(67), TRAF6(1), ZAK(7)	15023371	185	104	171	67	26	35	24	57	42	1	0.787	1.000	1.000
204	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(2), APC(12), AXIN1(14), CCND1(1), CTNNB1(59), DVL1(1), FZD1(1), GJA1(4), GNAI1(4), GSK3B(6), IRAK1(6), LBP(5), LEF1(4), LY96(1), MYD88(3), NFKB1(7), PDPK1(2), PIK3CA(10), PIK3R1(5), PPP2CA(4), RELA(4), TIRAP(2), TLR4(3), TOLLIP(1), WNT1(3)	9329502	164	103	132	49	21	29	22	63	27	2	0.364	1.000	1.000
205	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(1), IMPA1(3), IMPA2(3), INPP1(3), INPP4A(2), INPP4B(4), INPP5A(6), INPP5B(5), INPP5E(1), INPPL1(3), ITPK1(2), ITPKA(1), ITPKB(2), MINPP1(1), OCRL(5), PI4KA(5), PI4KB(1), PIK3C3(2), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIP4K2A(2), PIP4K2B(3), PIP4K2C(4), PIP5K1B(2), PIP5K1C(3), PLCB1(11), PLCB2(4), PLCB3(5), PLCB4(16), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(14), PLCG1(10), PLCG2(16), PLCZ1(2), PTEN(11), SYNJ1(10), SYNJ2(2)	22512034	201	102	199	112	44	52	25	46	33	1	1.000	1.000	1.000
206	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(6), ADCY6(9), ADCY8(12), CACNA1A(7), CACNA1B(15), GNAS(9), GNAT3(4), GNB1(4), GRM4(4), ITPR3(15), PDE1A(2), PLCB2(4), PRKACA(2), PRKACB(3), PRKACG(1), PRKX(4), SCNN1A(4), SCNN1G(6), TAS1R1(4), TAS1R2(4), TAS1R3(6), TAS2R1(2), TAS2R10(2), TAS2R13(2), TAS2R14(1), TAS2R16(3), TAS2R3(2), TAS2R38(1), TAS2R39(2), TAS2R4(1), TAS2R40(1), TAS2R41(2), TAS2R42(4), TAS2R43(10), TAS2R46(6), TAS2R50(2), TAS2R60(1), TAS2R7(5), TAS2R8(3), TAS2R9(1), TRPM5(4)	17492506	180	102	177	72	39	46	18	57	18	2	0.983	1.000	1.000
207	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(1), ATM(15), ATR(14), CCNA1(2), CCND1(1), CCNE1(2), CDC25A(2), CDK6(2), CDKN1A(6), CDKN1B(2), CDKN2A(3), E2F1(2), GSK3B(6), RB1(19), SKP2(3), TFDP1(3), TGFB1(1), TGFB2(4), TGFB3(3), TP53(67)	8966889	158	101	144	38	22	21	13	52	48	2	0.165	1.000	1.000
208	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(6), APOA2(1), CD36(1), CITED2(1), CPT1B(4), CREBBP(12), DUSP1(1), DUT(2), EHHADH(14), EP300(7), FABP1(1), HSD17B4(8), JUN(1), LPL(4), MAPK1(3), MAPK3(1), ME1(1), MRPL11(1), MYC(2), NCOA1(6), NCOR1(11), NCOR2(11), NFKBIA(2), NR0B2(3), NR1H3(3), NRIP1(4), PDGFA(2), PIK3CA(10), PIK3R1(5), PPARA(4), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(2), PTGS2(2), RB1(19), RELA(4), RXRA(6), SP1(2), SRA1(2), STAT5A(2), STAT5B(3), TNF(2)	19225874	185	101	184	75	35	44	18	47	38	3	0.980	1.000	1.000
209	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(2), AKT2(7), AKT3(4), BRAF(2), CAB39(3), EIF4B(3), EIF4EBP1(1), FIGF(1), HIF1A(3), IGF1(1), MAPK1(3), MAPK3(1), PDPK1(2), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PRKAA1(4), PRKAA2(4), RICTOR(9), RPS6(1), RPS6KA1(4), RPS6KA2(6), RPS6KA3(10), RPS6KA6(9), RPS6KB1(5), RPS6KB2(3), STK11(1), TSC1(13), TSC2(15), ULK1(8), ULK2(8), VEGFB(2), VEGFC(5)	16254507	187	100	184	41	43	51	18	37	36	2	0.00677	1.000	1.000
210	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	66	ADAM10(2), ADAM17(9), ATP6AP1(2), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(1), ATP6V0D2(3), ATP6V1A(3), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(3), ATP6V1D(2), ATP6V1E2(1), ATP6V1F(2), ATP6V1G3(1), ATP6V1H(2), CASP3(2), CDC42(2), CHUK(9), CSK(2), CXCL1(1), EGFR(7), F11R(1), GIT1(2), HBEGF(1), IGSF5(7), IKBKB(6), JAM2(3), JAM3(3), JUN(1), LYN(3), MAP2K4(4), MAP3K14(2), MAPK10(4), MAPK11(4), MAPK12(2), MAPK13(1), MAPK14(4), MAPK9(4), MET(2), NFKB1(7), NFKB2(2), NFKBIA(2), NOD1(2), PAK1(4), PLCG1(10), PLCG2(16), PTPN11(2), PTPRZ1(13), RAC1(1), RELA(4), SRC(2), TJP1(9)	21492559	204	99	203	82	48	46	20	56	34	0	0.961	1.000	1.000
211	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(12), AXIN1(14), CREBBP(12), CTNNB1(59), DVL1(1), EP300(7), FZD1(1), GSK3B(6), LDB1(1), LEF1(4), PITX2(1), TRRAP(19), WNT1(3)	9853185	140	99	109	44	15	31	15	54	23	2	0.530	1.000	1.000
212	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(3), ALG6(5), CCKBR(4), CCR2(4), CCR3(3), CCR5(2), CELSR1(22), CELSR2(10), CELSR3(14), CHRM2(5), CHRM3(4), CIDEB(2), CXCR3(1), EDNRA(3), EMR2(3), EMR3(4), F2R(2), FSHR(2), GHRHR(2), GNRHR(2), GPR116(9), GPR132(4), GPR133(6), GPR135(2), GPR143(1), GPR17(3), GPR18(3), GPR55(3), GPR56(2), GPR61(1), GPR84(6), GRM1(8), HRH4(3), LGR6(4), LPHN2(9), LPHN3(12), OR8G2(1), P2RY13(2), PTGFR(3), SSTR2(2), TAAR5(2), TSHR(4), VN1R1(3)	19842815	190	98	188	93	42	48	21	59	20	0	0.999	1.000	1.000
213	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(2), AKT2(7), AKT3(4), BRD4(5), CBL(8), CDC42(2), CDKN2A(3), FLOT1(6), FLOT2(1), GSK3A(2), GSK3B(6), INPPL1(3), IRS1(4), IRS2(2), IRS4(9), LNPEP(10), MAPK1(3), MAPK3(1), PARD3(5), PDK1(1), PIK3CA(10), PIK3CD(5), PIK3R1(5), PPYR1(2), PTEN(11), PTPN1(2), RAF1(2), RPS6KA1(4), RPS6KA2(6), RPS6KA3(10), RPS6KB1(5), SERPINB6(5), SFN(1), SHC1(5), SLC2A4(1), SORBS1(5), SOS1(10), SOS2(8), YWHAB(2), YWHAE(2), YWHAG(2), YWHAH(1), YWHAZ(1)	17509130	189	98	188	57	37	51	26	47	25	3	0.186	1.000	1.000
214	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	23	APC(12), AXIN1(14), BTRC(6), CCND1(1), CREBBP(12), CSNK1A1(1), CSNK2A1(2), CTBP1(2), CTNNB1(59), DVL1(1), FZD1(1), GSK3B(6), MAP3K7(3), MYC(2), NLK(3), PPARD(1), PPP2CA(4), TLE1(6), WIF1(5), WNT1(3)	8989800	144	98	113	42	18	33	12	52	26	3	0.390	1.000	1.000
215	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(2), CAD(7), CDA(2), CTPS2(3), DCTD(1), DHODH(4), DPYD(17), DUT(2), ENTPD1(6), ENTPD3(1), ENTPD4(2), ENTPD5(4), ENTPD6(4), NME1(1), NME4(1), NME6(1), NT5C(1), NT5C1A(2), NT5C1B(2), NT5C2(6), PNPT1(4), POLA1(10), POLA2(1), POLD1(5), POLD3(1), POLE(9), POLE2(7), POLE3(2), POLR1A(10), POLR1B(3), POLR1C(1), POLR1D(1), POLR2A(10), POLR2B(8), POLR2C(1), POLR2E(2), POLR2G(2), POLR2H(1), POLR2I(2), POLR3A(9), POLR3B(4), POLR3K(1), PRIM1(2), PRIM2(2), RFC5(3), RRM1(5), RRM2(2), TK1(2), TK2(3), TXNRD1(1), TXNRD2(2), UCK2(3), UMPS(2), UPB1(1), UPP1(1), UPP2(2), UPRT(2), ZNRD1(1)	24644269	197	97	194	108	51	53	18	50	23	2	1.000	1.000	1.000
216	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(2), ACTR3(3), AKT1(2), AKT2(7), AKT3(4), ARHGAP1(1), ARHGAP4(1), ARHGEF11(5), BTK(1), CDC42(2), CFL1(3), CFL2(2), GDI1(2), GDI2(1), INPPL1(3), ITPR1(18), ITPR2(19), ITPR3(15), LIMK1(2), MYLK(4), MYLK2(4), PAK1(4), PAK2(8), PAK3(6), PAK4(3), PAK6(4), PAK7(9), PDK1(1), PIK3CA(10), PIK3CD(5), PIK3CG(4), PIK3R1(5), PITX2(1), PPP1R13B(7), PTEN(11), RACGAP1(5), RHO(2), ROCK1(7), ROCK2(8), SAG(1), WASF1(2), WASL(2)	21338688	206	96	204	85	41	51	21	55	36	2	0.975	1.000	1.000
217	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(2), ACADL(6), ACADM(1), ACOX1(6), ACOX2(4), ACOX3(7), ACSL1(3), ACSL3(3), ACSL4(2), ACSL5(3), ACSL6(2), ANGPTL4(1), APOA2(1), APOA5(1), APOC3(1), AQP7(11), CD36(1), CPT1A(6), CPT1B(4), CPT1C(3), CPT2(1), CYP27A1(4), CYP4A11(5), CYP4A22(4), CYP7A1(3), CYP8B1(3), DBI(1), EHHADH(14), FABP1(1), FABP2(1), FABP4(1), FADS2(1), GK(3), GK2(3), HMGCS2(3), ILK(1), LPL(4), ME1(1), MMP1(3), NR1H3(3), OLR1(1), PCK1(6), PDPK1(2), PLTP(3), PPARA(4), PPARD(1), PPARG(1), RXRA(6), RXRB(5), RXRG(2), SCD(2), SCP2(2), SLC27A2(1), SLC27A4(1), SLC27A5(7), SLC27A6(3), SORBS1(5), UBC(4), UCP1(3)	19694085	187	95	180	72	29	38	30	65	25	0	0.824	1.000	1.000
218	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(9), CREBBP(12), CTBP1(2), CTBP2(5), DLL1(2), DLL3(6), DLL4(2), DTX2(5), DTX3(4), DTX3L(8), DTX4(1), DVL1(1), DVL2(5), EP300(7), HDAC2(5), HES1(4), JAG1(6), JAG2(6), LFNG(5), MAML1(1), MAML2(2), MAML3(2), MFNG(2), NCOR2(11), NCSTN(4), NOTCH1(6), NOTCH2(13), NOTCH3(16), NOTCH4(13), NUMB(2), NUMBL(3), PSEN1(2), PSENEN(1), RBPJ(2), RBPJL(1), SNW1(2)	21438483	178	95	177	104	50	31	20	55	22	0	1.000	1.000	1.000
219	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP10(4), CASP3(2), CASP6(2), CASP7(4), CASP8(3), CFLAR(2), DAXX(1), DFFA(2), DFFB(3), FADD(2), FAF1(6), JUN(1), LMNA(3), LMNB1(5), LMNB2(4), MAP2K4(4), MAP3K1(6), MAP3K7(3), PAK1(4), PAK2(8), PRKDC(26), PTPN13(21), RB1(19), RIPK2(2), SPTAN1(9)	12950722	147	94	145	46	27	31	11	39	38	1	0.492	1.000	1.000
220	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(2), CPEB1(2), EGFR(7), ERBB2(4), ERBB4(9), ETS1(1), ETS2(2), ETV6(2), ETV7(1), FMN2(9), KRAS(4), MAP2K1(5), MAPK1(3), MAPK3(1), NOTCH1(6), NOTCH2(13), NOTCH3(16), NOTCH4(13), PIWIL1(5), PIWIL2(6), PIWIL3(7), PIWIL4(18), RAF1(2), SOS1(10), SOS2(8), SPIRE1(9), SPIRE2(2)	15845781	167	94	164	83	46	35	17	51	17	1	0.997	1.000	1.000
221	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(2), AKT2(7), AKT3(4), ASAH1(4), BRAF(2), DRD2(2), EGFR(7), EPHB2(7), ITPKA(1), ITPKB(2), ITPR1(18), ITPR2(19), ITPR3(15), KCNJ3(1), KCNJ5(1), MAPK1(3), PI3(2), PIK3CB(12), PITX2(1), PLCB1(11), PLCB2(4), PLCB3(5), PLCB4(16), RAF1(2), RGS20(2), SHC1(5), SOS1(10), SOS2(8), SRC(2), STAT3(5), TERF2IP(1)	17667378	181	94	179	77	45	50	12	53	19	2	0.981	1.000	1.000
222	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(4), ADH1A(2), ADH1B(6), ADH5(1), ADH6(2), ADH7(3), ADHFE1(1), ALDH1A3(2), ALDH3A1(3), ALDH3B1(5), ALDH3B2(4), AOC2(3), AOC3(3), AOX1(10), CARM1(2), COMT(1), DBH(2), DCT(5), DDC(4), ECH1(3), ESCO1(4), ESCO2(5), FAH(1), GOT1(2), GOT2(2), GSTZ1(2), HEMK1(5), HGD(2), HPD(3), LCMT1(2), LCMT2(4), MAOA(4), MAOB(3), METTL2B(6), METTL6(1), NAT6(2), PNPLA3(3), PRMT3(2), PRMT5(4), PRMT6(4), PRMT7(1), PRMT8(3), SH3GLB1(2), TAT(1), TH(3), TPO(11), TYR(6), TYRP1(2), WBSCR22(1)	17718346	157	93	155	73	37	32	18	45	22	3	0.983	1.000	1.000
223	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(9), APC(12), AXIN1(14), BTRC(6), CTNNB1(59), DLL1(2), DVL1(1), FZD1(1), GSK3B(6), NOTCH1(6), PSEN1(2), WNT1(3)	6436142	121	91	90	35	15	24	12	48	20	2	0.365	1.000	1.000
224	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(3), ATP8A1(8), AVPR1B(2), BDKRB1(2), BDKRB2(4), BRS3(2), C3AR1(2), CCKBR(4), CCR1(3), CCR2(4), CCR3(3), CCR5(2), CCR6(4), CCR7(4), CCR8(1), CX3CR1(4), CXCR3(1), CXCR4(2), CXCR6(2), EDNRA(3), EDNRB(2), FPR1(2), FSHR(2), GALR1(2), GALT(1), GHSR(2), GNB2L1(2), GNRHR(2), LHCGR(7), MC1R(1), MC2R(4), MC3R(2), MC4R(2), MC5R(5), NMBR(3), NPY1R(4), NPY2R(4), NPY5R(4), OPRK1(2), OPRL1(1), OPRM1(10), OXTR(2), PPYR1(2), SSTR2(2), SSTR3(6), SSTR4(2), TAC4(2), TACR1(5), TACR2(6), TACR3(4), TRHR(5), TSHR(4)	15263756	164	90	162	81	37	29	16	62	20	0	0.999	1.000	1.000
225	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(3), BMP4(1), BMP5(3), BMP7(3), BTRC(6), CSNK1A1(1), CSNK1A1L(4), CSNK1E(3), CSNK1G1(4), CSNK1G3(1), FBXW11(8), GLI1(7), GLI2(11), GLI3(13), GSK3B(6), HHIP(7), LRP2(27), PRKACA(2), PRKACB(3), PRKACG(1), PRKX(4), PTCH1(3), PTCH2(8), RAB23(2), SHH(2), STK36(11), SUFU(4), WNT1(3), WNT10B(1), WNT16(2), WNT2(3), WNT3A(1), WNT4(1), WNT5B(1), WNT6(2), WNT7A(2), WNT7B(1), WNT8A(2), WNT8B(1), WNT9B(1)	17848394	169	89	168	73	40	36	19	53	18	3	0.987	1.000	1.000
226	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(2), AKT2(7), AKT3(4), BCR(4), BLNK(3), BTK(1), CD19(1), CSK(2), EPHB2(7), ITPKA(1), ITPKB(2), LYN(3), MAP2K1(5), MAP2K2(3), MAPK1(3), NFAT5(13), NFKB1(7), NFKB2(2), NFKBIA(2), NFKBIE(1), NFKBIL1(3), PI3(2), PIK3CA(10), PIK3CD(5), PIK3R1(5), PLCG2(16), PPP1R13B(7), RAF1(2), SERPINA4(3), SHC1(5), SOS1(10), SOS2(8), SYK(4), VAV1(6)	15856107	159	89	158	60	42	36	25	40	15	1	0.751	1.000	1.000
227	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(1), CALR(6), CANX(5), CD4(3), CD74(1), CD8A(1), CD8B(4), CIITA(5), CREB1(1), CTSB(2), CTSL1(2), HLA-A(11), HLA-B(6), HLA-C(1), HLA-DMA(4), HLA-DMB(4), HLA-DOA(1), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(8), HLA-DQA1(4), HLA-DQA2(1), HLA-DQB1(3), HLA-DRB1(4), HLA-DRB5(3), HLA-E(4), HLA-G(1), HSP90AA1(10), HSP90AB1(4), HSPA5(4), IFNA13(1), IFNA14(2), IFNA16(2), IFNA17(6), IFNA2(2), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(5), IFNA8(2), KIR2DL1(4), KIR2DL3(7), KIR3DL1(2), KIR3DL3(1), KLRC1(1), KLRC2(1), KLRC4(2), KLRD1(1), LGMN(1), LTA(2), NFYA(4), NFYC(2), PSME1(1), PSME2(2), RFX5(4), RFXANK(1), RFXAP(1), TAP1(3), TAP2(2), TAPBP(2)	14218289	178	88	172	78	34	28	25	62	29	0	0.993	1.000	1.000
228	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(3), INPP1(3), INPP4A(2), INPP4B(4), INPP5A(6), INPPL1(3), ITPKA(1), ITPKB(2), OCRL(5), PIK3C2A(8), PIK3C2B(9), PIK3C2G(11), PIK3CA(10), PIK3CB(12), PIK3CG(4), PLCB1(11), PLCB2(4), PLCB3(5), PLCB4(16), PLCD1(1), PLCG1(10), PLCG2(16)	13669738	146	88	144	77	34	38	17	31	26	0	1.000	1.000	1.000
229	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(2), AKT1(2), BDKRB2(4), CALM1(1), CAV1(1), CHRNA1(3), FLT1(11), FLT4(9), KDR(13), NOS3(8), PDE2A(6), PDE3A(7), PDE3B(9), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKG1(5), PRKG2(11), RYR2(47), SYT1(1), TNNI1(1)	12690420	150	88	147	53	29	35	16	49	19	2	0.774	1.000	1.000
230	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), BAG4(5), CASP2(1), CASP3(2), CASP8(3), CRADD(1), DFFA(2), DFFB(3), FADD(2), JUN(1), LMNA(3), LMNB1(5), LMNB2(4), MADD(6), MAP2K4(4), MAP3K1(6), MAP3K7(3), PAK1(4), PAK2(8), PRKDC(26), RB1(19), RIPK1(6), SPTAN1(9), TNF(2), TNFRSF1A(2)	11995976	128	88	126	48	22	26	9	34	36	1	0.909	1.000	1.000
231	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	44	AGL(9), AMY2A(5), AMY2B(2), ENPP1(4), ENPP3(8), G6PC(4), GAA(2), GANAB(5), GBE1(1), GCK(3), GPI(2), GUSB(6), GYS1(2), GYS2(5), HK1(4), HK2(8), HK3(6), MGAM(18), PGM1(3), PGM3(6), PYGB(1), PYGL(8), PYGM(9), RNPC3(1), SI(14), UCHL1(1), UCHL3(1), UGDH(4), UGT1A1(1), UGT1A10(3), UGT1A3(2), UGT1A4(1), UGT1A5(13), UGT1A8(1), UGT1A9(1), UGT2B15(5), UGT2B4(5)	20222499	174	86	171	91	35	39	28	46	24	2	0.999	1.000	1.000
232	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(2), AANAT(2), ABP1(4), ACAT1(1), ACAT2(6), ACMSD(2), AFMID(3), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH7A1(2), ALDH9A1(2), AOC2(3), AOC3(3), AOX1(10), ASMT(1), CARM1(2), CAT(1), CYP1A1(4), CYP1B1(2), DDC(4), ECHS1(2), EHHADH(14), GCDH(2), HAAO(1), HADH(1), HADHA(3), HEMK1(5), HSD17B4(8), KMO(3), KYNU(4), LCMT1(2), LCMT2(4), LNX1(2), MAOA(4), MAOB(3), METTL2B(6), METTL6(1), NFX1(7), OGDH(4), OGDHL(2), PRMT3(2), PRMT5(4), PRMT6(4), PRMT7(1), PRMT8(3), TDO2(5), TPH1(3), TPH2(4), WARS(6), WARS2(1), WBSCR22(1)	18105712	176	85	175	78	41	41	20	55	17	2	0.962	1.000	1.000
233	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(2), APC(12), AR(12), ASAH1(4), BRAF(2), CAMP(1), CCL13(1), CCL15(4), CCL16(1), EGFR(7), GNA15(2), GNAI1(4), ITPKA(1), ITPKB(2), ITPR1(18), ITPR2(19), ITPR3(15), KCNJ3(1), KCNJ5(1), MAPK1(3), MAPK10(4), MAPK14(4), PHKA2(5), PIK3CA(10), PIK3CD(5), PIK3R1(5), PITX2(1), PTX3(1), RAF1(2), SRC(2)	16268817	151	85	147	77	31	38	16	49	15	2	0.999	1.000	1.000
234	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(2), ABP1(4), ACAT1(1), ACAT2(6), ACMSD(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(2), AOC2(3), AOC3(3), AOX1(10), ASMT(1), CAT(1), CYP19A1(4), CYP1A1(4), CYP2A13(4), CYP2A6(6), CYP2A7(12), CYP2B6(4), CYP2C18(4), CYP2C8(3), CYP2C9(4), CYP2D6(3), CYP2E1(2), CYP2F1(3), CYP2J2(4), CYP3A4(1), CYP3A5(4), CYP3A7(6), CYP4B1(6), CYP4F8(1), CYP51A1(2), DDC(4), ECHS1(2), EHHADH(14), GCDH(2), HAAO(1), HADHA(3), KMO(3), KYNU(4), MAOA(4), MAOB(3), SDS(4), TDO2(5), TPH1(3), WARS(6), WARS2(1)	16553027	185	85	181	73	44	42	19	51	29	0	0.905	1.000	1.000
235	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(3), AKR1D1(3), ARSD(5), ARSE(2), CARM1(2), CYP11B1(4), CYP11B2(9), CYP19A1(4), HEMK1(5), HSD11B1(2), HSD17B2(1), HSD17B3(3), HSD17B7(2), HSD3B1(1), LCMT1(2), LCMT2(4), METTL2B(6), METTL6(1), PRMT3(2), PRMT5(4), PRMT6(4), PRMT7(1), PRMT8(3), STS(3), SULT1E1(1), SULT2A1(3), SULT2B1(3), UGT1A1(1), UGT1A10(3), UGT1A3(2), UGT1A4(1), UGT1A5(13), UGT1A8(1), UGT1A9(1), UGT2A1(5), UGT2A3(3), UGT2B10(2), UGT2B11(3), UGT2B15(5), UGT2B17(1), UGT2B28(13), UGT2B4(5), UGT2B7(5), WBSCR22(1)	14641355	148	84	142	75	29	39	16	45	17	2	0.998	1.000	1.000
236	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(2), AGPAT1(3), AGPAT2(1), AGPAT3(4), AGPAT4(1), AGPAT6(5), CDIPT(1), CDS1(1), CDS2(1), CHAT(5), CHKA(1), CHPT1(3), DGKA(5), DGKB(2), DGKD(4), DGKE(4), DGKG(6), DGKH(4), DGKI(4), DGKZ(7), ESCO1(4), ESCO2(5), ETNK1(2), ETNK2(1), GNPAT(5), GPAM(9), GPD1(1), GPD1L(4), LCAT(3), LYPLA1(1), LYPLA2(2), NAT6(2), PCYT1A(4), PCYT1B(2), PEMT(2), PHOSPHO1(1), PISD(2), PLA2G12A(2), PLA2G12B(2), PLA2G1B(1), PLA2G2A(1), PLA2G2D(3), PLA2G2E(1), PLA2G2F(6), PLA2G3(4), PLA2G4A(6), PLA2G6(6), PLD1(6), PLD2(5), PNPLA3(3), PPAP2A(3), PPAP2B(1), PPAP2C(4), PTDSS1(2), PTDSS2(1), SH3GLB1(2)	20088499	173	84	172	75	38	39	26	44	26	0	0.954	1.000	1.000
237	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(2), ACTR3(3), AKT1(2), DGKA(5), ETFA(1), GCA(2), ITGA9(8), ITPKA(1), ITPKB(2), ITPR1(18), ITPR2(19), ITPR3(15), MAP2K1(5), MAPK1(3), MAPK3(1), PAK1(4), PDE3A(7), PDE3B(9), PI3(2), PIK3C2G(11), PIK3CA(10), PIK3CD(5), PIK3R1(5), PSME1(1), RIPK3(5), SGCB(2), VASP(3)	14935328	151	84	149	58	45	32	18	42	13	1	0.809	1.000	1.000
238	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(8), CSK(2), CTLA4(3), EPHB2(7), FBXW7(3), GRAP2(3), ITK(2), ITPKA(1), ITPKB(2), LCK(5), LCP2(4), MAPK1(3), NCK1(1), NFAT5(13), NFKB1(7), NFKB2(2), NFKBIA(2), NFKBIE(1), NFKBIL1(3), PAK1(4), PAK2(8), PAK3(6), PAK4(3), PAK6(4), PAK7(9), PLCG1(10), PTPRC(9), RAF1(2), RASGRP1(9), RASGRP2(3), RASGRP3(4), RASGRP4(6), SOS1(10), SOS2(8), VAV1(6), ZAP70(3)	17216741	176	84	175	76	47	47	17	45	19	1	0.960	1.000	1.000
239	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(1), ALPL(3), ALPP(6), ALPPL2(3), ASCC3(15), ATP13A2(8), DDX18(4), DDX19A(2), DDX23(4), DDX4(3), DDX41(3), DDX47(2), DDX50(4), DDX51(4), DDX52(5), DDX54(4), DDX55(4), DDX56(1), DHX58(6), ENTPD7(4), EP400(12), ERCC2(5), ERCC3(4), FPGS(4), GGH(1), IFIH1(5), MOV10L1(2), NUDT5(1), PTS(2), QDPR(1), RAD54B(5), RAD54L(2), RUVBL2(1), SETX(20), SKIV2L2(4), SMARCA2(11), SMARCA5(2)	18987859	168	83	166	102	40	47	14	43	22	2	1.000	1.000	1.000
240	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH1A(2), ADH1B(6), ADH5(1), ADH6(2), ADH7(3), ADHFE1(1), AKR1C1(2), AKR1C2(4), AKR1C3(1), AKR1C4(3), ALDH1A3(2), ALDH3A1(3), ALDH3B1(5), ALDH3B2(4), CYP1A1(4), CYP1B1(2), CYP2B6(4), CYP2C18(4), CYP2C8(3), CYP2C9(4), CYP2E1(2), CYP2F1(3), CYP2S1(2), CYP3A4(1), CYP3A43(3), CYP3A5(4), CYP3A7(6), DHDH(1), EPHX1(4), GSTA2(2), GSTA4(2), GSTA5(1), GSTK1(1), GSTM2(1), GSTM3(1), GSTM5(2), GSTO2(2), GSTP1(4), GSTT1(1), GSTT2(3), GSTZ1(2), MGST1(1), MGST3(1), UGT1A1(1), UGT1A10(3), UGT1A3(2), UGT1A4(1), UGT1A5(13), UGT1A8(1), UGT1A9(1), UGT2A1(5), UGT2A3(3), UGT2B10(2), UGT2B11(3), UGT2B15(5), UGT2B17(1), UGT2B28(13), UGT2B4(5), UGT2B7(5)	17306769	174	83	165	96	31	44	16	48	34	1	1.000	1.000	1.000
241	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(2), DOCK1(14), FOS(2), GAB1(5), HGF(9), ITGA1(7), ITGB1(3), JUN(1), MAP2K1(5), MAP2K2(3), MAP4K1(5), MAPK1(3), MAPK3(1), MET(2), PAK1(4), PIK3CA(10), PIK3R1(5), PTEN(11), PTK2(9), PTK2B(8), PTPN11(2), PXN(5), RAF1(2), RAP1A(2), RASA1(10), SOS1(10), SRC(2), STAT3(5)	13678389	147	83	146	44	28	42	18	35	22	2	0.286	1.000	1.000
242	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(2), EGF(10), EGFR(7), FOS(2), JAK1(8), JUN(1), MAP2K1(5), MAP2K4(4), MAP3K1(6), MAPK3(1), PIK3CA(10), PIK3R1(5), PLCG1(10), PRKCA(2), RAF1(2), RASA1(10), SHC1(5), SOS1(10), SRF(1), STAT1(7), STAT3(5), STAT5A(2)	11315737	115	81	114	38	19	33	13	26	23	1	0.642	1.000	1.000
243	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	52	ACTA1(2), AGT(2), AKT1(2), CALM1(1), CALR(6), CAMK1G(3), CAMK4(1), CREBBP(12), CSNK1A1(1), EDN1(2), ELSPBP1(9), F2(2), GATA4(1), GSK3B(6), HAND2(2), IGF1(1), LIF(1), MAP2K1(5), MAPK1(3), MAPK14(4), MAPK3(1), MEF2C(3), MYH2(14), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), NKX2-5(1), NPPA(1), PIK3CA(10), PIK3R1(5), PPP3CA(6), PPP3CB(5), PPP3CC(1), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), RAF1(2), RPS6KB1(5), SYT1(1)	15012655	146	81	142	47	39	40	15	32	19	1	0.423	1.000	1.000
244	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(7), CDA(2), CTPS2(3), DCTD(1), DHODH(4), DPYD(17), DUT(2), ENTPD1(6), NME1(1), NT5C(1), POLB(4), POLD1(5), POLE(9), POLG(7), POLL(1), POLQ(18), POLR1B(3), POLR2A(10), POLR2B(8), POLR2C(1), POLR2E(2), POLR2G(2), POLR2H(1), POLR2I(2), POLRMT(1), RRM1(5), RRM2(2), TK1(2), TK2(3), TXNRD1(1), UCK2(3), UMPS(2), UNG(4), UPB1(1), UPP1(1)	17355819	142	81	140	63	32	40	13	38	19	0	0.961	1.000	1.000
245	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	94	ANK2(16), B3GALT4(3), CDR1(2), DGKI(4), FAU(1), IL6ST(14), MRPL19(1), RPL10(2), RPL11(1), RPL13(2), RPL15(1), RPL18(3), RPL18A(1), RPL22(1), RPL23(1), RPL27(1), RPL29(1), RPL3(2), RPL37(1), RPL38(1), RPL3L(1), RPL4(1), RPL41(1), RPL5(2), RPL6(2), RPL7A(2), RPL9(1), RPS10(1), RPS13(2), RPS14(1), RPS18(1), RPS2(1), RPS23(1), RPS24(1), RPS27A(2), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(2), RPS6(1), RPS6KA1(4), RPS6KA2(6), RPS6KA3(10), RPS6KA6(9), RPS6KB1(5), RPS6KB2(3), RPS9(2), SLC36A2(8), TBC1D10C(1), UBA52(1), UBC(4)	15604890	139	80	138	58	28	36	19	30	26	0	0.920	1.000	1.000
246	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(2), ASAH1(4), ATF1(2), BRAF(2), CAMP(1), CREB1(1), CREB3(2), CREB5(5), CREBBP(12), EGR2(3), EGR3(5), EGR4(1), FRS2(1), JUN(1), MAP1B(12), MAP2K4(4), MAP2K7(2), MAPK1(3), MAPK10(4), MAPK3(1), MAPK8IP3(2), MAPK9(4), NTRK1(5), PIK3C2G(11), PIK3CA(10), PIK3CD(5), PIK3R1(5), PTPN11(2), RPS6KA3(10), SHC1(5), SRC(2), TERF2IP(1), TH(3)	15747673	133	80	132	47	28	38	18	33	15	1	0.587	1.000	1.000
247	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM1(1), FOS(2), FYN(2), JUN(1), LCK(5), MAP2K1(5), MAP2K4(4), MAP3K1(6), MAPK3(1), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), NFKB1(7), NFKBIA(2), PIK3CA(10), PIK3R1(5), PLCG1(10), PPP3CA(6), PPP3CB(5), PPP3CC(1), PRKCA(2), PTPN7(2), RAC1(1), RAF1(2), RASA1(10), RELA(4), SHC1(5), SOS1(10), SYT1(1), VAV1(6), ZAP70(3)	14277764	135	80	134	53	27	31	16	39	21	1	0.893	1.000	1.000
248	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(2), AGPAT1(3), AGPAT2(1), AGPAT3(4), AGPAT4(1), AGPS(3), CDIPT(1), CDS1(1), CDS2(1), CHAT(5), CHKA(1), CLC(1), CPT1B(4), DGKA(5), DGKB(2), DGKD(4), DGKE(4), DGKG(6), DGKH(4), DGKZ(7), ETNK1(2), GNPAT(5), GPD1(1), LCAT(3), LYPLA1(1), LYPLA2(2), PAFAH1B1(1), PAFAH2(1), PCYT1A(4), PCYT1B(2), PEMT(2), PISD(2), PLA2G1B(1), PLA2G2A(1), PLA2G2E(1), PLA2G3(4), PLA2G4A(6), PLA2G6(6), PLCB2(4), PLCG1(10), PLCG2(16), PPAP2A(3), PPAP2B(1), PPAP2C(4)	15359531	143	79	142	62	36	39	18	33	17	0	0.950	1.000	1.000
249	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(2), AASDHPPT(2), AASS(8), ACAT1(1), ACAT2(6), AKR1B10(1), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH7A1(2), ALDH9A1(2), BBOX1(1), DLST(2), DOT1L(9), ECHS1(2), EHHADH(14), EHMT1(5), EHMT2(7), GCDH(2), HADH(1), HADHA(3), HSD17B4(8), HSD3B7(2), NSD1(14), OGDH(4), OGDHL(2), PIPOX(2), PLOD1(5), PLOD2(7), PLOD3(1), RDH11(2), RDH12(2), RDH13(1), SETD1A(7), SETD7(3), SETDB1(5), SHMT1(4), SHMT2(2), SPCS1(1), SPCS3(1), SUV39H1(1), SUV39H2(3), TMLHE(2)	17254068	159	78	158	61	37	30	18	50	24	0	0.788	1.000	1.000
250	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(2), ADH1B(6), ADH5(1), ADH6(2), ADH7(3), ADHFE1(1), AGK(2), AGPAT1(3), AGPAT2(1), AGPAT3(4), AGPAT4(1), AGPAT6(5), AKR1A1(3), AKR1B1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH7A1(2), ALDH9A1(2), CEL(2), DAK(1), DGAT1(2), DGAT2(1), DGKA(5), DGKB(2), DGKD(4), DGKE(4), DGKG(6), DGKH(4), DGKI(4), DGKZ(7), GK(3), GK2(3), GLA(1), GLB1(6), GPAM(9), LCT(7), LIPA(5), LIPC(6), LIPF(3), LIPG(2), LPL(4), MGLL(1), PNLIP(1), PNLIPRP1(5), PNLIPRP2(2), PNPLA3(3), PPAP2A(3), PPAP2B(1), PPAP2C(4)	17917138	161	78	159	94	32	38	25	38	28	0	1.000	1.000	1.000
251	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(1), CHUK(9), DAXX(1), EGF(10), EGFR(7), ETS1(1), ETS2(2), FOS(2), IKBKB(6), JUN(1), MAP2K1(5), MAP2K4(4), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K14(2), MAP3K5(6), MAPK1(3), MAPK13(1), MAPK14(4), MAPK3(1), NFKB1(7), NFKBIA(2), PPP2CA(4), PRKCA(2), PRKCD(4), PRKCG(2), PRKCH(2), PRKCQ(2), RAF1(2), RELA(4), RIPK1(6), SP1(2), TNF(2), TNFRSF1A(2), TNFRSF1B(3)	14232946	121	78	121	65	26	26	15	33	21	0	1.000	1.000	1.000
252	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(2), FOS(2), JAK1(8), JUN(1), MAP2K1(5), MAP2K4(4), MAP3K1(6), MAPK3(1), PDGFA(2), PDGFRA(10), PIK3CA(10), PIK3R1(5), PLCG1(10), PRKCA(2), RAF1(2), RASA1(10), SHC1(5), SOS1(10), SRF(1), STAT1(7), STAT3(5), STAT5A(2)	10566493	110	76	109	34	22	29	14	24	20	1	0.483	1.000	1.000
253	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(2), CALM1(1), CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), CDK5(1), F2(2), FYN(2), GNAI1(4), GNB1(4), GNGT1(1), JAK2(9), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK14(4), MAPK3(1), MAPT(12), MYLK(4), PLCG1(10), PRKCA(2), PTK2B(8), RAF1(2), SHC1(5), SOS1(10), STAT1(7), STAT3(5), STAT5A(2), SYT1(1)	12786358	123	75	123	41	30	41	9	19	23	1	0.661	1.000	1.000
254	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(1), CALM1(1), FCER1A(2), FOS(2), JUN(1), LYN(3), MAP2K1(5), MAP2K4(4), MAP2K7(2), MAP3K1(6), MAPK1(3), MAPK3(1), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), PAK2(8), PIK3CA(10), PIK3R1(5), PLA2G4A(6), PLCG1(10), PPP3CA(6), PPP3CB(5), PPP3CC(1), RAF1(2), SHC1(5), SOS1(10), SYK(4), SYT1(1), VAV1(6)	12740850	126	75	125	48	28	31	16	34	16	1	0.755	1.000	1.000
255	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(11), ATP4A(8), ATP4B(1), ATP5A1(3), ATP5B(3), ATP5C1(2), ATP5D(1), ATP5F1(1), ATP5G1(1), ATP5G2(1), ATP5G3(2), ATP5H(1), ATP5L(2), ATP6AP1(2), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(1), ATP6V0D2(3), ATP6V1A(3), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(3), ATP6V1D(2), ATP6V1E2(1), ATP6V1F(2), ATP6V1G3(1), ATP6V1H(2), COX10(3), COX15(3), COX4I1(1), COX4I2(1), COX5A(2), COX5B(2), COX6A1(1), COX6B1(1), CYC1(1), LHPP(1), NDUFA1(1), NDUFA10(5), NDUFA5(2), NDUFA8(1), NDUFA9(1), NDUFAB1(1), NDUFB11(1), NDUFB5(1), NDUFB7(1), NDUFB8(1), NDUFC2(1), NDUFS1(3), NDUFS2(1), NDUFS4(2), NDUFV2(2), NDUFV3(4), PPA1(2), PPA2(4), SDHA(5), SDHB(3), UQCRB(1), UQCRC2(1), UQCRFS1(2), UQCRH(1)	17045140	142	75	138	76	31	36	17	42	16	0	0.999	1.000	1.000
256	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(4), AGXT(5), AGXT2(3), AKR1B10(1), ALAS1(2), ALAS2(3), AMT(1), AOC2(3), AOC3(3), BHMT(2), CBS(5), CHDH(7), CHKA(1), CTH(3), DAO(7), DLD(2), DMGDH(3), GAMT(1), GARS(2), GATM(6), GCAT(2), GLDC(9), GNMT(1), HSD3B7(2), MAOA(4), MAOB(3), PEMT(2), PHGDH(5), PIPOX(2), PISD(2), PSAT1(3), PSPH(2), RDH11(2), RDH12(2), RDH13(1), SARDH(6), SARS(2), SARS2(4), SDS(4), SHMT1(4), SHMT2(2), TARS(4), TARS2(4)	13001648	136	75	136	49	36	32	15	36	17	0	0.721	1.000	1.000
257	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(2), AKT2(7), AKT3(4), CISH(2), IARS(9), IL13RA1(5), IL2RG(1), IL4(1), IL4R(4), INPP5D(3), JAK1(8), JAK2(9), JAK3(5), NR0B2(3), PI3(2), PIK3CA(10), PPP1R13B(7), RPS6KB1(5), SERPINA4(3), SHC1(5), SOS1(10), SOS2(8), SRC(2), STAT6(6), TYK2(7)	11055864	128	75	127	33	29	39	17	27	15	1	0.0668	1.000	1.000
258	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(2), EIF1(1), EIF2B2(2), EIF2B3(3), EIF2B4(1), EIF2B5(5), EIF2S1(1), EIF2S2(1), EIF2S3(2), ELAVL1(5), FLT1(11), FLT4(9), HIF1A(3), KDR(13), NOS3(8), PIK3CA(10), PIK3R1(5), PLCG1(10), PRKCA(2), PTK2(9), PXN(5), SHC1(5), VHL(1)	10459780	114	75	111	37	21	37	7	33	16	0	0.532	1.000	1.000
259	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(2), ACTN1(5), ACTN2(8), ACTN3(1), BCAR1(3), BCR(4), CAPN1(3), CAPNS1(1), CAV1(1), CSK(2), FYN(2), ITGA1(7), ITGB1(3), JUN(1), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), PPP1R12B(5), PTK2(9), PXN(5), RAF1(2), RAP1A(2), ROCK1(7), SHC1(5), SOS1(10), SRC(2), TLN1(12), VCL(4), ZYX(2)	14264277	120	74	120	37	26	29	15	32	17	1	0.519	1.000	1.000
260	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(2), AASDH(8), AASDHPPT(2), AASS(8), ACAT1(1), ACAT2(6), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(2), ATP6V0C(1), BBOX1(1), DLST(2), DOT1L(9), ECHS1(2), EHHADH(14), EHMT1(5), EHMT2(7), GCDH(2), HADHA(3), PLOD1(5), PLOD2(7), PLOD3(1), SDS(4), SHMT1(4), SHMT2(2), TMLHE(2)	10951605	114	74	113	52	21	24	10	40	19	0	0.973	1.000	1.000
261	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(7), AKT1(2), AKT2(7), AKT3(4), BTK(1), CDKN2A(3), DAPP1(1), GSK3A(2), GSK3B(6), IARS(9), INPP5D(3), PDK1(1), PIK3CA(10), PPP1R13B(7), PTEN(11), RPS6KA1(4), RPS6KA2(6), RPS6KA3(10), RPS6KB1(5), SFN(1), SHC1(5), SOS1(10), SOS2(8), TEC(2), YWHAB(2), YWHAE(2), YWHAG(2), YWHAH(1), YWHAZ(1)	10701255	133	74	132	40	24	33	22	34	18	2	0.204	1.000	1.000
262	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(2), ACSS2(3), ACYP1(1), ACYP2(1), ADH1A(2), ADH1B(6), ADH5(1), ADH6(2), ADH7(3), ADHFE1(1), AKR1A1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(5), ALDH3B2(4), ALDH7A1(2), ALDH9A1(2), ALDOB(3), DLAT(4), DLD(2), ENO1(2), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(4), G6PC2(4), GALM(1), GAPDHS(6), GCK(3), GPI(2), HK1(4), HK2(8), HK3(6), LDHA(1), LDHAL6A(2), LDHAL6B(7), LDHB(2), LDHC(2), PDHA1(1), PDHA2(4), PDHB(2), PFKL(3), PFKM(2), PFKP(6), PGAM1(1), PGAM2(1), PGAM4(1), PGK1(2), PGK2(2), PGM1(3), PGM3(6), PKLR(1)	17446419	151	73	148	87	41	30	14	34	31	1	1.000	1.000	1.000
263	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(1), ALOX12(1), ALOX12B(4), ALOX15(3), ALOX15B(4), ALOX5(4), CBR3(2), CYP2B6(4), CYP2C18(4), CYP2C8(3), CYP2C9(4), CYP2E1(2), CYP2J2(4), CYP2U1(3), CYP4A11(5), CYP4A22(4), CYP4F2(3), CYP4F3(1), DHRS4(3), EPHX2(2), GPX1(2), GPX2(2), GPX5(2), GPX6(2), GPX7(1), LTA4H(5), PLA2G12A(2), PLA2G12B(2), PLA2G1B(1), PLA2G2A(1), PLA2G2D(3), PLA2G2E(1), PLA2G2F(6), PLA2G3(4), PLA2G4A(6), PLA2G6(6), PTGES(1), PTGES2(2), PTGIS(2), PTGS1(3), PTGS2(2), TBXAS1(2)	12037237	119	73	117	60	30	27	16	32	14	0	0.998	1.000	1.000
264	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(10), AR(12), ESR1(4), ESR2(3), ESRRA(4), HNF4A(1), NPM1(3), NR0B1(1), NR1D1(3), NR1H2(3), NR1H3(3), NR1I2(1), NR2C2(4), NR2E1(1), NR2F2(4), NR3C1(4), NR4A1(4), NR4A2(5), NR5A1(2), NR5A2(3), PGR(8), PPARA(4), PPARD(1), PPARG(1), RARA(2), RARB(3), RARG(7), ROR1(7), RORA(3), RORC(1), RXRA(6), RXRB(5), RXRG(2), THRA(1), THRB(1), VDR(2)	12733927	129	73	126	61	22	31	18	41	17	0	0.994	1.000	1.000
265	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(4), AGMAT(3), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH4A1(4), ALDH9A1(2), AMD1(3), AOC2(3), AOC3(3), ARG1(3), ARG2(2), ASL(2), CKB(1), CKM(2), CKMT1A(1), CKMT1B(1), CKMT2(5), CPS1(10), DAO(7), GAMT(1), GATM(6), GLUD1(3), GOT1(2), GOT2(2), MAOA(4), MAOB(3), NOS1(15), NOS3(8), OAT(3), ODC1(3), OTC(3), P4HA1(1), P4HA2(4), P4HA3(2), P4HB(1), PYCR1(2), RARS(3), SMS(1)	13552394	137	72	136	63	29	34	10	49	15	0	0.991	1.000	1.000
266	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	26	BRCA1(11), CARM1(2), CCND1(1), CREBBP(12), EP300(7), ERCC3(4), ESR1(4), GRIP1(7), GTF2A1(3), GTF2E1(3), GTF2F1(1), HDAC2(5), HDAC3(2), HDAC4(5), HDAC5(3), HDAC6(8), MEF2C(3), NCOR2(11), NR0B1(1), NRIP1(4), PELP1(8), POLR2A(10), SRA1(2)	14356353	117	72	116	67	34	24	14	26	18	1	0.999	1.000	1.000
267	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(4), CDT1(3), DIAPH2(6), GMNN(2), MCM10(6), MCM2(5), MCM3(3), MCM4(4), MCM5(3), MCM6(4), MCM7(6), NACA(6), POLA2(1), POLD1(5), POLD3(1), POLE(9), POLE2(7), PRIM1(2), RFC1(7), RFC2(2), RFC3(2), RFC4(1), RFC5(3), RPA1(5), RPA2(2), RPA3(1), RPS27A(2), UBA52(1), UBC(4)	15310592	108	72	107	53	19	28	12	36	13	0	0.973	1.000	1.000
268	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(7), GNAS(9), GNB1(4), GNGT1(1), IGF1R(12), ITGB1(3), KLK2(3), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MKNK1(2), MKNK2(1), MYC(2), NGFR(1), PDGFRA(10), PPP2CA(4), PTPRR(4), RAF1(2), RPS6KA1(4), RPS6KA5(3), SHC1(5), SOS1(10), SRC(2), STAT3(5)	10081925	106	72	103	35	32	25	13	27	8	1	0.506	1.000	1.000
269	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(10), ACACB(14), ACAT1(1), ACAT2(6), ACOT12(5), ACSS1(2), ACSS2(3), ACYP1(1), ACYP2(1), AKR1B1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH7A1(2), ALDH9A1(2), DLAT(4), DLD(2), GLO1(5), HAGH(2), HAGHL(2), LDHA(1), LDHAL6A(2), LDHAL6B(7), LDHB(2), LDHC(2), LDHD(1), MDH1(1), MDH2(2), ME1(1), ME2(5), ME3(1), PC(10), PCK1(6), PDHA1(1), PDHA2(4), PDHB(2), PKLR(1)	13861092	123	72	121	76	29	25	24	30	15	0	1.000	1.000	1.000
270	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(2), BCL2(1), CBL(8), CFLAR(2), E2F1(2), FOS(2), IL2RA(2), IL2RB(3), IL2RG(1), IRS1(4), JAK1(8), JAK3(5), MAPK1(3), MAPK3(1), MYC(2), NMI(4), PIK3CA(10), PIK3R1(5), PPIA(2), PTPN6(2), RAF1(2), RPS6KB1(5), SHC1(5), SOS1(10), STAT5A(2), STAT5B(3), SYK(4)	10862168	100	72	99	30	29	24	13	21	12	1	0.315	1.000	1.000
271	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(7), COL4A2(10), COL4A3(4), COL4A4(11), COL4A5(9), COL4A6(11), F10(3), F2(2), F2R(2), F5(18), F8(11), F9(1), FGA(9), FGB(2), FGG(4), KLKB1(7), PROC(5), PROS1(4), SERPINC1(4), SERPING1(1)	13531048	125	72	121	68	22	37	23	32	11	0	0.924	1.000	1.000
272	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	35	AKT1(2), AKT2(7), AKT3(4), ARHGEF11(5), BCL2(1), CDC42(2), DLG4(3), GNA13(2), LPA(10), MAP2K4(4), MAP3K1(6), MAP3K5(6), NFKB1(7), NFKB2(2), NFKBIA(2), NFKBIE(1), NFKBIL1(3), PDK1(1), PHKA2(5), PI3(2), PIK3CB(12), PLD1(6), PLD2(5), PLD3(5), PTK2(9), RDX(4), ROCK1(7), ROCK2(8), SERPINA4(3), SRF(1)	15279265	135	72	134	58	23	39	15	33	24	1	0.961	1.000	1.000
273	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(14), EEF1A2(3), EEF1G(2), EEF2(2), EEF2K(5), EIF1AX(1), EIF2AK1(4), EIF2AK2(3), EIF2AK3(9), EIF2B2(2), EIF2B3(3), EIF2B4(1), EIF2B5(5), EIF2S1(1), EIF2S2(1), EIF2S3(2), EIF4A1(1), EIF4A2(2), EIF4E(2), EIF4EBP1(1), EIF4EBP2(1), EIF4G1(10), EIF4G3(10), EIF5(2), EIF5A(2), EIF5B(4), ETF1(3), PABPC1(9), PABPC3(8), SLC35A4(1)	13319673	114	72	110	54	23	35	16	22	17	1	0.935	1.000	1.000
274	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(4), AGXT(5), AGXT2(3), ALAS1(2), ALAS2(3), AMT(1), AOC2(3), AOC3(3), ATP6V0C(1), BHMT(2), CBS(5), CHDH(7), CHKA(1), CPT1B(4), CTH(3), DAO(7), DLD(2), DMGDH(3), GAMT(1), GARS(2), GATM(6), GCAT(2), GLDC(9), MAOA(4), MAOB(3), PEMT(2), PISD(2), PLCB2(4), PLCG1(10), PLCG2(16), PSPH(2), SARDH(6), SARS(2), SHMT1(4), SHMT2(2), TARS(4)	12761200	140	71	140	51	36	40	15	32	17	0	0.762	1.000	1.000
275	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(3), DLAT(4), DLD(2), ENO1(2), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(4), GAPDHS(6), GCK(3), GOT1(2), GOT2(2), GPI(2), HK1(4), HK2(8), HK3(6), LDHA(1), LDHAL6B(7), LDHB(2), LDHC(2), MDH1(1), MDH2(2), PC(10), PCK1(6), PDHA1(1), PDHA2(4), PDHB(2), PDHX(4), PFKL(3), PFKM(2), PFKP(6), PGAM1(1), PGAM2(1), PGK1(2), PGK2(2), PKLR(1), TNFAIP1(1)	12570232	114	71	113	62	33	31	15	18	17	0	0.997	1.000	1.000
276	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(3), ACAA1(2), ACAA2(2), ACADM(1), ACADS(3), ACAT1(1), ACAT2(6), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH6A1(6), ALDH7A1(2), ALDH9A1(2), AOX1(10), AUH(2), BCAT1(5), BCAT2(2), BCKDHA(4), BCKDHB(2), DBT(3), DLD(2), ECHS1(2), EHHADH(14), HADH(1), HADHA(3), HADHB(2), HIBADH(1), HIBCH(5), HMGCL(1), HMGCS1(4), HMGCS2(3), HSD17B4(8), IVD(2), MCCC1(4), MCCC2(1), MUT(4), OXCT1(7), PCCA(3), PCCB(5)	13191510	138	71	137	54	30	39	15	34	20	0	0.592	1.000	1.000
277	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(4), ARG1(3), ARG2(2), ASL(2), ASS1(2), CKB(1), CKM(2), CKMT1A(1), CKMT1B(1), CKMT2(5), CPS1(10), DAO(7), EPRS(7), GAMT(1), GATM(6), GLUD1(3), GLUD2(3), GOT1(2), GOT2(2), LAP3(4), NOS1(15), NOS3(8), OAT(3), OTC(3), P4HA1(1), P4HA2(4), P4HA3(2), PARS2(4), PRODH(3), PYCR1(2), PYCR2(1), PYCRL(2), RARS(3), RARS2(5)	11160757	124	71	123	55	26	29	10	44	14	1	0.978	1.000	1.000
278	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(3), ABO(1), B3GALNT1(3), B3GALT1(1), B3GALT2(1), B3GALT4(3), B3GNT2(2), B3GNT4(1), B4GALNT1(4), B4GALT2(2), B4GALT3(2), B4GALT4(1), B4GALT6(5), FUT1(2), FUT2(1), FUT3(3), FUT5(4), FUT6(3), FUT7(2), FUT9(2), GBGT1(4), GCNT2(7), PIGA(3), PIGB(3), PIGC(1), PIGF(3), PIGG(5), PIGH(2), PIGL(3), PIGM(6), PIGN(8), PIGO(4), PIGQ(5), PIGS(6), PIGU(2), PIGV(1), PIGX(2), PIGZ(4), ST3GAL1(1), ST3GAL3(4), ST3GAL4(1), ST3GAL5(2), ST3GAL6(3), ST6GALNAC3(4), ST6GALNAC4(1), ST6GALNAC5(3), ST6GALNAC6(1), ST8SIA1(4), ST8SIA5(1), UGCG(2)	14718015	142	71	140	52	35	30	14	45	18	0	0.796	1.000	1.000
279	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(2), AKT2(7), AKT3(4), BCL2(1), GSK3A(2), GSK3B(6), IL4R(4), IRS1(4), IRS2(2), JAK1(8), JAK3(5), MAP4K1(5), MAPK1(3), MAPK3(1), PDK1(1), PIK3CA(10), PIK3CD(5), PIK3R1(5), PPP1R13B(7), RAF1(2), SHC1(5), SOS1(10), SOS2(8), STAT6(6)	10864619	113	71	112	38	26	27	15	29	15	1	0.565	1.000	1.000
280	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(1), ACTG2(1), ACTR2(2), ACTR3(3), AKT1(2), CDC42(2), CFL1(3), CFL2(2), FLNA(8), FLNC(10), FSCN1(3), FSCN3(1), GDI1(2), GDI2(1), LIMK1(2), MYH2(14), MYLK(4), MYLK2(4), PAK1(4), PAK2(8), PAK3(6), PAK4(3), PAK6(4), PAK7(9), RHO(2), ROCK1(7), ROCK2(8), VASP(3), WASF1(2), WASL(2)	14521490	123	71	122	57	24	35	11	26	27	0	0.991	1.000	1.000
281	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(1), AKT1(2), APC(12), ASAH1(4), CAMP(1), DLG4(3), EPHB2(7), GNAI1(4), ITPR1(18), ITPR2(19), ITPR3(15), KCNJ3(1), KCNJ5(1), MAPK1(3), PITX2(1), PTX3(1), RAC1(1), RHO(2), RYR1(26)	13971684	122	71	121	76	32	30	9	35	14	2	1.000	1.000	1.000
282	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(10), BAX(1), BCL2(1), BCL2A1(5), CASP1(4), CASP10(4), CASP2(1), CASP3(2), CASP4(4), CASP6(2), CASP7(4), CASP8(3), CASP9(1), CD40(4), CRADD(1), DAXX(1), DFFA(2), DFFB(3), FADD(2), FAS(5), FASLG(2), IKBKE(2), LTA(2), MCL1(2), NFKB1(7), NFKBIA(2), NGFR(1), NR3C1(4), NTRK1(5), PTPN13(21), RIPK1(6), TNF(2), TNFRSF1A(2), TNFRSF1B(3), TRAF1(3), TRAF3(1), TRAF6(1)	13166880	126	70	126	46	24	27	17	41	17	0	0.699	1.000	1.000
283	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(7), AKT1(2), ASAH1(4), GNAI1(4), GNB1(4), GNGT1(1), ITGAV(9), ITGB3(3), MAPK1(3), MAPK3(1), PDGFA(2), PDGFRA(10), PIK3CA(10), PIK3R1(5), PLCB1(11), PRKCA(2), PTK2(9), RAC1(1), SMPD1(3), SMPD2(2), SPHK1(6), SRC(2)	8136078	101	70	99	32	19	28	11	27	16	0	0.441	1.000	1.000
284	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(2), ADH1B(6), ADH6(2), ADH7(3), ADHFE1(1), AGPAT1(3), AGPAT2(1), AGPAT3(4), AGPAT4(1), AKR1A1(3), AKR1B1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(2), CEL(2), DGAT1(2), DGKA(5), DGKB(2), DGKD(4), DGKE(4), DGKG(6), DGKH(4), DGKZ(7), GK(3), GLA(1), GLB1(6), LCT(7), LIPC(6), LIPF(3), LIPG(2), LPL(4), PNLIP(1), PNLIPRP1(5), PNLIPRP2(2), PPAP2A(3), PPAP2B(1), PPAP2C(4)	14767468	128	70	126	82	29	31	19	29	20	0	1.000	1.000	1.000
285	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(5), AARS2(7), CARS(4), CARS2(2), DARS(1), EARS2(1), EPRS(7), FARS2(2), FARSA(1), FARSB(1), GARS(2), HARS(1), HARS2(3), IARS(9), IARS2(2), KARS(1), LARS(5), LARS2(2), MARS(7), MARS2(1), MTFMT(2), NARS2(3), PARS2(4), QARS(3), RARS(3), RARS2(5), SARS(2), SARS2(4), TARS(4), TARS2(4), VARS(2), VARS2(12), WARS(6), WARS2(1), YARS2(3)	16202126	122	70	122	65	30	33	9	33	15	2	0.996	1.000	1.000
286	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(4), ADH1A(2), ADH1B(6), ADH6(2), ADH7(3), ADHFE1(1), ALDH1A3(2), ALDH3A1(3), ALDH3B1(5), ALDH3B2(4), AOC2(3), AOC3(3), AOX1(10), COMT(1), DBH(2), DCT(5), DDC(4), FAH(1), GOT1(2), GOT2(2), GSTZ1(2), HGD(2), HPD(3), MAOA(4), MAOB(3), TAT(1), TH(3), TPO(11), TYR(6)	9503672	100	70	98	51	20	19	10	32	18	1	0.994	1.000	1.000
287	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(6), DIAPH1(6), FYN(2), GSN(2), ITGA1(7), ITGB1(3), MAP2K1(5), MAPK1(3), MAPK3(1), MYLK(4), PIK3CA(10), PIK3R1(5), PTK2(9), PXN(5), RAF1(2), ROCK1(7), SHC1(5), SRC(2), TLN1(12)	11328089	96	69	95	29	13	31	10	25	17	0	0.417	1.000	1.000
288	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(2), ACAA2(2), ACADL(6), ACADM(1), ACADS(3), ACADSB(1), ACADVL(3), ACAT1(1), ACAT2(6), ACOX1(6), ACOX3(7), ACSL1(3), ACSL3(3), ACSL4(2), ACSL5(3), ACSL6(2), ADH1A(2), ADH1B(6), ADH5(1), ADH6(2), ADH7(3), ADHFE1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH7A1(2), ALDH9A1(2), CPT1A(6), CPT1B(4), CPT1C(3), CPT2(1), CYP4A11(5), CYP4A22(4), ECHS1(2), EHHADH(14), GCDH(2), HADH(1), HADHA(3), HADHB(2), HSD17B4(8)	14662437	135	69	132	74	24	27	18	47	19	0	0.998	1.000	1.000
289	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(2), ALAS1(2), ALAS2(3), BLVRA(2), COX10(3), COX15(3), CP(6), CPOX(3), EARS2(1), EPRS(7), FECH(2), FTMT(2), GUSB(6), HCCS(2), HMBS(3), HMOX1(1), HMOX2(2), MMAB(1), PPOX(3), UGT1A1(1), UGT1A10(3), UGT1A3(2), UGT1A4(1), UGT1A5(13), UGT1A8(1), UGT1A9(1), UGT2A1(5), UGT2A3(3), UGT2B10(2), UGT2B11(3), UGT2B15(5), UGT2B17(1), UGT2B28(13), UGT2B4(5), UGT2B7(5), UROS(3)	12197429	121	69	115	65	19	23	12	42	24	1	1.000	1.000	1.000
290	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	ADRBK1(5), AKT1(2), AKT2(7), AKT3(4), ITPKA(1), ITPKB(2), ITPR1(18), ITPR2(19), ITPR3(15), NFKB1(7), NFKB2(2), NFKBIA(2), NFKBIE(1), NFKBIL1(3), PDK1(1), PHKA2(5), PIK3CB(12), PITX2(1), PLD1(6), PLD2(5), PLD3(5), VN1R1(3)	13928629	126	69	124	49	36	25	9	40	15	1	0.918	1.000	1.000
291	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(2), AKR1B10(1), B4GALT2(2), G6PC(4), G6PC2(4), GAA(2), GALK1(3), GALK2(1), GALT(1), GANC(3), GCK(3), GLA(1), GLB1(6), HK1(4), HK2(8), HK3(6), HSD3B7(2), LALBA(1), LCT(7), MGAM(18), PFKL(3), PFKM(2), PFKP(6), PGM1(3), PGM3(6), RDH11(2), RDH12(2), RDH13(1), UGP2(2)	11581293	106	68	105	54	27	22	16	27	14	0	0.986	1.000	1.000
292	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(2), ARSD(5), ARSE(2), ASAH1(4), B4GALT6(5), CERK(2), DEGS1(2), DEGS2(1), ENPP7(3), GALC(6), GBA(1), GLA(1), GLB1(6), LCT(7), NEU1(5), NEU2(3), NEU3(2), NEU4(3), PPAP2A(3), PPAP2B(1), PPAP2C(4), SGMS1(2), SGMS2(1), SGPP1(1), SGPP2(1), SMPD1(3), SMPD2(2), SMPD3(1), SMPD4(4), SPHK1(6), SPHK2(4), SPTLC1(2), SPTLC2(4), UGCG(2), UGT8(1)	10679376	102	68	101	51	26	25	15	28	8	0	0.977	1.000	1.000
293	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(7), ADRBK2(4), ARRB2(2), CALM1(1), CALML6(1), CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), CLCA1(9), CLCA2(10), CLCA4(6), CNGA3(8), CNGA4(3), CNGB1(6), GNAL(4), GUCA1B(2), GUCA1C(2), PDC(1), PDE1C(11), PRKACA(2), PRKACB(3), PRKACG(1), PRKG1(5), PRKG2(11), PRKX(4)	9345154	116	68	116	43	30	25	12	33	13	3	0.792	1.000	1.000
294	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(1), CAMK1G(3), FPR1(2), GNA15(2), GNB1(4), GNGT1(1), MAP2K1(5), MAP2K2(3), MAP2K6(1), MAP3K1(6), MAPK1(3), MAPK14(4), MAPK3(1), NCF2(4), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), NFKB1(7), NFKBIA(2), PAK1(4), PIK3C2G(11), PLCB1(11), PPP3CA(6), PPP3CB(5), PPP3CC(1), RAC1(1), RAF1(2), RELA(4), SYT1(1)	11727242	111	67	111	56	22	30	13	30	16	0	0.996	1.000	1.000
295	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(3), ANAPC10(1), ANAPC2(4), ANAPC4(1), ANAPC5(6), ANAPC7(3), BTRC(6), CDC16(4), CDC20(1), CDC23(3), CDC27(16), CUL1(3), CUL2(5), CUL3(7), FBXW11(8), FBXW7(3), FZR1(4), ITCH(2), SKP2(3), SMURF1(4), SMURF2(3), TCEB2(1), UBA1(7), UBE2C(1), UBE2D1(1), UBE2D2(2), UBE2D3(2), UBE2E1(3), VHL(1), WWP1(6), WWP2(3)	12461563	117	67	107	79	21	27	15	30	24	0	1.000	1.000	1.000
296	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(2), AKR1B10(1), ALDOB(3), FBP1(2), FBP2(1), FPGT(4), FUK(4), GMDS(2), GMPPA(5), GMPPB(2), HK1(4), HK2(8), HK3(6), HSD3B7(2), KHK(1), LHPP(1), MPI(2), MTMR1(2), MTMR2(3), MTMR6(5), PFKFB1(4), PFKFB2(2), PFKFB3(5), PFKFB4(3), PFKL(3), PFKM(2), PFKP(6), PGM2(7), PHPT1(1), PMM1(3), PMM2(1), RDH11(2), RDH12(2), RDH13(1), SORD(4), TSTA3(1)	11343325	107	66	107	49	23	26	17	26	15	0	0.969	1.000	1.000
297	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(4), ALDH1A3(2), ALDH3A1(3), ALDH3B1(5), ALDH3B2(4), AOC2(3), AOC3(3), DDC(4), EPX(8), ESCO1(4), ESCO2(5), GOT1(2), GOT2(2), HPD(3), LPO(8), MAOA(4), MAOB(3), MPO(11), NAT6(2), PNPLA3(3), PRDX6(1), SH3GLB1(2), TAT(1), TPO(11)	10162320	98	66	96	32	21	17	15	31	13	1	0.373	1.000	1.000
298	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(10), POLA2(1), POLB(4), POLD1(5), POLD3(1), POLE(9), POLE2(7), POLE3(2), POLG(7), POLG2(2), POLH(2), POLI(5), POLK(3), POLL(1), POLQ(18), PRIM1(2), PRIM2(2), REV1(11), REV3L(16), RFC5(3)	12430872	111	66	109	44	29	33	6	27	15	1	0.719	1.000	1.000
299	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ACTG2(1), ADCY3(7), ADCY9(9), ARF1(2), ARF3(1), ARF4(1), ARF5(3), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(1), ATP6V0D2(3), ATP6V1A(3), ATP6V1C1(1), ATP6V1C2(3), ATP6V1D(2), ATP6V1E2(1), ATP6V1F(2), ATP6V1G3(1), ATP6V1H(2), ERO1L(1), GNAS(9), PDIA4(1), PLCG1(10), PLCG2(16), PRKCA(2), SEC61A1(3), SEC61G(1), TRIM23(3)	11187942	105	66	103	42	32	25	9	22	17	0	0.945	1.000	1.000
300	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(1), BCR(4), BLNK(3), FOS(2), JUN(1), LYN(3), MAP2K1(5), MAP3K1(6), MAPK1(3), MAPK3(1), MAPK8IP3(2), PAPPA(9), RAC1(1), RPS6KA1(4), RPS6KA3(10), SHC1(5), SOS1(10), SYK(4), VAV1(6), VAV2(2), VAV3(7)	9625454	89	66	89	34	18	22	16	24	8	1	0.657	1.000	1.000
301	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(2), AGTR1(3), ATF2(1), CALM1(1), EGFR(7), JUN(1), MAP2K1(5), MAP2K2(3), MAP2K4(4), MAP3K1(6), MAPK1(3), MAPK3(1), MEF2A(4), MEF2C(3), MEF2D(1), PAK1(4), PRKCA(2), PTK2(9), PTK2B(8), RAC1(1), RAF1(2), SHC1(5), SOS1(10), SRC(2), SYT1(1)	10276822	89	65	89	38	20	25	8	20	15	1	0.943	1.000	1.000
302	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	39	ARNTL(3), AZIN1(13), BTG1(1), CBX3(3), CLDN5(1), CLOCK(4), CRY1(5), DNAJA1(2), EIF4G2(6), ETV6(2), GFRA1(3), GSTM3(1), GSTP1(4), HSPA8(1), IDI1(2), KLF9(2), MYF6(1), NCKAP1(6), NCOA4(4), PER1(4), PER2(7), PIGF(3), PPP1R3C(2), PPP2CB(3), PSMA4(3), SF3A3(4), TOB1(2), TUBB3(1), UCP3(2), UGP2(2), VAPA(1), ZFR(4)	10901160	102	65	90	49	27	30	6	21	18	0	0.938	1.000	1.000
303	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ACYP2(1), ADH1A(2), ADH1B(6), ADH6(2), ADH7(3), ADHFE1(1), AKR1A1(3), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(5), ALDH3B2(4), ALDH9A1(2), ALDOB(3), DLAT(4), DLD(2), ENO1(2), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(4), GCK(3), GPI(2), HK1(4), HK2(8), HK3(6), LDHA(1), LDHB(2), LDHC(2), PDHA1(1), PDHA2(4), PDHB(2), PFKM(2), PFKP(6), PGAM1(1), PGK1(2), PGM1(3), PGM3(6), PKLR(1)	14614061	120	65	118	83	36	23	10	25	25	1	1.000	1.000	1.000
304	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ACYP2(1), ADH1A(2), ADH1B(6), ADH6(2), ADH7(3), ADHFE1(1), AKR1A1(3), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(5), ALDH3B2(4), ALDH9A1(2), ALDOB(3), DLAT(4), DLD(2), ENO1(2), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(4), GCK(3), GPI(2), HK1(4), HK2(8), HK3(6), LDHA(1), LDHB(2), LDHC(2), PDHA1(1), PDHA2(4), PDHB(2), PFKM(2), PFKP(6), PGAM1(1), PGK1(2), PGM1(3), PGM3(6), PKLR(1)	14614061	120	65	118	83	36	23	10	25	25	1	1.000	1.000	1.000
305	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(5), AARS2(7), ABAT(3), ACY3(2), ADSL(1), ADSS(3), ADSSL1(2), AGXT(5), AGXT2(3), ASL(2), ASNS(6), ASPA(1), ASRGL1(2), ASS1(2), CAD(7), CRAT(3), DARS(1), DDO(2), DLAT(4), DLD(2), GAD1(5), GAD2(2), GOT1(2), GOT2(2), GPT(5), GPT2(3), NARS2(3), PC(10), PDHA1(1), PDHA2(4), PDHB(2)	11405815	102	65	102	54	27	28	11	29	7	0	0.994	1.000	1.000
306	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(3), ACACA(10), ACACB(14), ACADM(1), ACAT1(1), ACAT2(6), ACSS1(2), ACSS2(3), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH6A1(6), ALDH7A1(2), ALDH9A1(2), ECHS1(2), EHHADH(14), HADHA(3), HIBCH(5), LDHA(1), LDHAL6A(2), LDHAL6B(7), LDHB(2), LDHC(2), MUT(4), PCCA(3), PCCB(5), SUCLA2(3), SUCLG1(2), SUCLG2(2)	11878078	117	65	116	65	25	30	18	31	13	0	0.991	1.000	1.000
307	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(2), AADAC(3), ABAT(3), ACADS(3), ACAT1(1), ACAT2(6), ACSM1(5), AKR1B10(1), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH7A1(2), ALDH9A1(2), BDH1(1), BDH2(3), DDHD1(5), ECHS1(2), EHHADH(14), GAD1(5), GAD2(2), HADH(1), HADHA(3), HMGCL(1), HMGCS1(4), HMGCS2(3), HSD17B4(8), HSD3B7(2), ILVBL(1), L2HGDH(2), OXCT1(7), PDHA1(1), PDHA2(4), PDHB(2), PLA1A(3), PPME1(2), PRDX6(1), RDH11(2), RDH12(2), RDH13(1)	12338995	120	65	119	64	30	25	16	38	11	0	0.993	1.000	1.000
308	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX12(1), ALOX15(3), ALOX5(4), CBR3(2), CYP4F2(3), CYP4F3(1), EPX(8), LPO(8), LTA4H(5), MPO(11), PLA2G1B(1), PLA2G2A(1), PLA2G2E(1), PLA2G3(4), PLA2G4A(6), PLA2G6(6), PRDX1(1), PRDX2(2), PRDX5(3), PRDX6(1), PTGES2(2), PTGIS(2), PTGS1(3), PTGS2(2), TBXAS1(2), TPO(11)	8523085	95	65	95	45	22	17	15	27	14	0	0.977	1.000	1.000
309	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ACTR3(3), ARHGAP1(1), ARHGAP4(1), ARHGAP5(6), ARHGAP6(3), ARHGEF1(3), ARHGEF11(5), ARHGEF5(4), ARPC1A(2), ARPC1B(2), ARPC2(5), ARPC4(2), BAIAP2(3), CFL1(3), DIAPH1(6), GSN(2), LIMK1(2), MYLK(4), OPHN1(4), PIP5K1B(2), PPP1R12B(5), ROCK1(7), SRC(2), TLN1(12), VCL(4)	14402231	95	65	95	47	20	23	7	23	22	0	0.998	1.000	1.000
310	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(2), BRAF(2), CREB1(1), CREB3(2), CREB5(5), DUSP6(3), DUSP9(2), EEF2K(5), EIF4E(2), MAP2K1(5), MAP2K2(3), MAP3K8(2), MAPK1(3), MAPK3(1), MKNK1(2), MKNK2(1), MOS(1), NFKB1(7), RAP1A(2), RPS6KA1(4), RPS6KA2(6), RPS6KA3(10), SHC1(5), SOS1(10), SOS2(8), TRAF3(1)	8966629	95	65	95	33	28	22	14	23	7	1	0.435	1.000	1.000
311	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	32	CHUK(9), FOS(2), IKBKB(6), IRAK1(6), JUN(1), LY96(1), MAP2K4(4), MAP2K6(1), MAP3K1(6), MAP3K14(2), MAP3K7(3), MAPK14(4), MYD88(3), NFKB1(7), NFKBIA(2), PPARA(4), RELA(4), TIRAP(2), TLR10(6), TLR2(2), TLR3(4), TLR4(3), TLR6(6), TLR7(7), TLR9(3), TOLLIP(1), TRAF6(1)	11182813	100	65	99	52	17	24	13	28	18	0	0.998	1.000	1.000
312	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(2), ACAA2(2), ACADL(6), ACADM(1), ACADS(3), ACADSB(1), ACAT1(1), ACAT2(6), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH6A1(6), ALDH9A1(2), AOX1(10), BCAT1(5), BCKDHA(4), BCKDHB(2), ECHS1(2), EHHADH(14), HADHA(3), HADHB(2), HIBADH(1), HMGCL(1), IVD(2), MCCC1(4), MCCC2(1), MUT(4), OXCT1(7), PCCA(3), PCCB(5), SDS(4)	10914097	118	65	117	53	23	31	14	29	21	0	0.872	1.000	1.000
313	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(7), CALM1(1), CREB1(1), FOS(2), GNAI1(4), GNAS(9), GNB1(4), GNGT1(1), JUN(1), MAP2K1(5), MAPK3(1), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), PLCG1(10), PPP3CA(6), PPP3CB(5), PPP3CC(1), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(2), RAF1(2), RPS6KA3(10), SYT1(1)	10364483	98	64	96	33	19	25	11	26	16	1	0.659	1.000	1.000
314	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(3), ADC(1), ALDH4A1(4), CAD(7), CPS1(10), EARS2(1), EPRS(7), GAD1(5), GAD2(2), GCLM(1), GFPT1(2), GFPT2(2), GLS(4), GLS2(3), GLUD1(3), GLUD2(3), GLUL(3), GMPS(3), GNPNAT1(2), GOT1(2), GOT2(2), GPT(5), GPT2(3), GSR(3), GSS(4), NADSYN1(4), NAGK(3), PPAT(3), QARS(3)	11824743	98	64	98	48	25	25	8	27	12	1	0.987	1.000	1.000
315	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(4), ACY3(2), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(5), ALDH3B2(4), ALDH7A1(2), ALDH9A1(2), AMDHD1(4), AOC2(3), AOC3(3), ASPA(1), CARM1(2), CNDP1(2), DDC(4), FTCD(5), HAL(2), HARS(1), HARS2(3), HDC(5), HEMK1(5), LCMT1(2), LCMT2(4), MAOA(4), MAOB(3), METTL2B(6), METTL6(1), PRMT3(2), PRMT5(4), PRMT6(4), PRMT7(1), PRMT8(3), PRPS1(1), PRPS2(3), UROC1(4), WBSCR22(1)	11909085	112	64	110	47	29	16	15	35	14	3	0.916	1.000	1.000
316	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(2), ATF1(2), CDC42(2), CREB1(1), CREB3(2), CREB5(5), DUSP1(1), EEF2K(5), EIF4E(2), GADD45A(1), IL1R1(4), MAP2K4(4), MAP2K6(1), MAP3K10(1), MAP3K4(9), MAP3K5(6), MAP3K7(3), MAPK1(3), MAPK11(4), MAPK12(2), MAPK13(1), MAPK14(4), MAPKAPK2(4), MAPKAPK5(4), MKNK1(2), MKNK2(1), MYEF2(4), NFKB1(7), NR2C2(4), SRF(1), TRAF6(1)	10273418	93	64	90	38	23	22	11	22	14	1	0.873	1.000	1.000
317	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(10), BCL2(1), BID(2), BIRC2(6), BIRC3(6), CASP10(4), CASP3(2), CASP6(2), CASP7(4), CASP8(3), CASP9(1), CFLAR(2), CHUK(9), DFFA(2), DFFB(3), FADD(2), GAS2(1), LMNA(3), MAP3K14(2), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(6), SPTAN1(9), TNFRSF10A(4), TNFRSF10B(2), TNFRSF25(3), TNFSF10(2)	10057912	104	63	104	40	19	24	9	31	21	0	0.869	1.000	1.000
318	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT2(2), FBP2(1), G6PC(4), GAA(2), GALK1(3), GALK2(1), GALT(1), GANAB(5), GCK(3), GLA(1), GLB1(6), HK1(4), HK2(8), HK3(6), LALBA(1), LCT(7), MGAM(18), PFKM(2), PFKP(6), PGM1(3), PGM3(6)	9784352	92	63	91	49	25	20	16	21	10	0	0.985	1.000	1.000
319	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(11), ATP4B(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(3), ATP6V1D(2), ATP6V1F(2), ATP6V1G3(1), ATP6V1H(2), ATP7A(9), ATP7B(8), COX10(3), COX4I1(1), COX5A(2), COX5B(2), COX6A1(1), COX6B1(1), NDUFA1(1), NDUFA10(5), NDUFA5(2), NDUFA8(1), NDUFB5(1), NDUFB7(1), NDUFS1(3), NDUFS2(1), NDUFV2(2), PPA2(4), SDHA(5), SDHB(3), SHMT1(4), UQCRB(1), UQCRFS1(2), UQCRH(1)	11515534	111	63	107	48	28	24	14	33	12	0	0.908	1.000	1.000
320	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(3), BTK(1), CALM1(1), CD79A(1), FOS(2), JUN(1), LYN(3), MAP2K1(5), MAP3K1(6), MAPK14(4), MAPK3(1), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), PLCG1(10), PPP3CA(6), PPP3CB(5), PPP3CC(1), PRKCA(2), RAC1(1), RAF1(2), SHC1(5), SOS1(10), SYK(4), SYT1(1), VAV1(6)	11296590	97	62	97	42	23	27	13	23	10	1	0.875	1.000	1.000
321	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA1A(3), ADRA1B(2), ADRA1D(3), ADRA2A(1), ADRA2C(1), ADRB1(1), ADRB2(5), ADRB3(1), CHRM2(5), CHRM3(4), CHRM4(1), CHRM5(3), DRD2(2), DRD3(5), DRD5(8), HRH1(1), HRH2(3), HTR1A(1), HTR1B(1), HTR1D(2), HTR1E(2), HTR1F(3), HTR2A(2), HTR2B(4), HTR2C(7), HTR4(1), HTR5A(1), HTR6(4), HTR7(10)	7598955	87	62	79	38	28	15	6	30	8	0	0.930	1.000	1.000
322	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(1), CDC42(2), CREB1(1), DAXX(1), DDIT3(1), HMGN1(1), HSPB2(4), MAP2K4(4), MAP2K6(1), MAP3K1(6), MAP3K5(6), MAP3K7(3), MAP3K9(5), MAPK14(4), MAPKAPK2(4), MAPKAPK5(4), MEF2A(4), MEF2C(3), MEF2D(1), MKNK1(2), MYC(2), PLA2G4A(6), RAC1(1), RIPK1(6), RPS6KA5(3), SHC1(5), STAT1(7), TGFB1(1), TGFB2(4), TGFB3(3), TGFBR1(5)	11259626	101	62	99	46	15	24	19	28	15	0	0.965	1.000	1.000
323	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), ITPKA(1), ITPKB(2), ITPR1(18), ITPR2(19), ITPR3(15), NFAT5(13), PDE6A(7), PDE6B(7), PDE6C(5), SLC6A13(3), TF(3)	10960521	106	62	105	53	32	25	4	31	13	1	0.997	1.000	1.000
324	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10B(3), ALG11(2), ALG12(1), ALG13(9), ALG2(6), ALG3(1), ALG5(1), ALG6(5), ALG8(1), ALG9(4), B4GALT2(2), B4GALT3(2), DDOST(1), DHDDS(1), DOLPP1(1), DPAGT1(3), DPM1(1), FUT8(2), GANAB(5), MAN1A1(3), MAN1A2(4), MAN1B1(1), MAN1C1(5), MAN2A1(7), MGAT1(3), MGAT2(2), MGAT3(8), MGAT4A(2), MGAT5(5), MGAT5B(5), RFT1(3), RPN1(2), RPN2(2), ST6GAL1(2), STT3B(3)	12853827	109	61	108	54	27	23	14	25	18	2	0.977	1.000	1.000
325	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(4), ALDH1A3(2), ALDH3A1(3), ALDH3B1(5), ALDH3B2(4), AOC2(3), AOC3(3), DDC(4), EPX(8), GOT1(2), GOT2(2), HPD(3), LPO(8), MAOA(4), MAOB(3), MPO(11), PRDX1(1), PRDX2(2), PRDX5(3), PRDX6(1), TAT(1), TPO(11)	6612574	88	61	86	28	18	15	13	27	14	1	0.438	1.000	1.000
326	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(8), EGF(10), EGFR(7), MAP2K1(5), MAPK1(3), MAPK3(1), PTPRB(14), RAF1(2), RASA1(10), SHC1(5), SOS1(10), SPRY1(1), SPRY2(2), SPRY3(2), SPRY4(1), SRC(2)	7528603	83	61	83	33	18	22	7	21	14	1	0.821	1.000	1.000
327	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	AKT1(2), CABIN1(8), CALM1(1), CAMK1G(3), HDAC5(3), IGF1(1), IGF1R(12), INSR(11), MAP2K6(1), MAPK14(4), MAPK7(6), MEF2A(4), MEF2C(3), MEF2D(1), MYOD1(3), NFATC1(3), NFATC2(4), PIK3CA(10), PIK3R1(5), PPP3CA(6), PPP3CB(5), PPP3CC(1), SYT1(1), YWHAH(1)	10400627	99	60	98	31	22	17	16	31	13	0	0.459	1.000	1.000
328	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(9), IFNB1(1), IKBKB(6), IL1A(3), IL1B(2), IL1R1(4), IL1RAP(4), IL6(3), IRAK1(6), IRAK2(3), IRAK3(4), JUN(1), MAP2K6(1), MAP3K1(6), MAP3K14(2), MAP3K7(3), MAPK14(4), MYD88(3), NFKB1(7), NFKBIA(2), RELA(4), TGFB1(1), TGFB2(4), TGFB3(3), TNF(2), TOLLIP(1), TRAF6(1)	8916246	90	60	90	39	14	20	13	29	14	0	0.939	1.000	1.000
329	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(1), CREBBP(12), EP300(7), FYN(2), IL2RG(1), IL7(2), IL7R(10), JAK1(8), JAK3(5), LCK(5), NMI(4), PIK3CA(10), PIK3R1(5), PTK2B(8), STAT5A(2), STAT5B(3)	8451988	85	60	82	36	15	19	10	23	18	0	0.954	1.000	1.000
330	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(2), CAPN1(3), CAPN2(1), CAPNS1(1), CXCR3(1), EGF(10), EGFR(7), ITGA1(7), ITGB1(3), MAPK1(3), MAPK3(1), MYLK(4), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PTK2(9), PXN(5), TLN1(12)	10073893	78	60	78	29	13	27	4	17	16	1	0.818	1.000	1.000
331	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(10), ACAT1(1), ACAT2(6), ACYP1(1), ACYP2(1), ADH5(1), AKR1B1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(2), DLAT(4), DLD(2), GLO1(5), HAGH(2), HAGHL(2), LDHA(1), LDHB(2), LDHC(2), LDHD(1), MDH1(1), MDH2(2), ME1(1), ME2(5), ME3(1), PC(10), PCK1(6), PDHA1(1), PDHA2(4), PDHB(2), PKLR(1)	10969880	93	60	92	62	22	17	18	22	14	0	1.000	1.000	1.000
332	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(5), ACP2(1), ACP5(2), ACPP(5), ACPT(1), ALPI(1), ALPL(3), ALPP(6), ALPPL2(3), CYP19A1(4), CYP1A1(4), CYP2A13(4), CYP2A6(6), CYP2A7(12), CYP2B6(4), CYP2C18(4), CYP2C8(3), CYP2C9(4), CYP2D6(3), CYP2E1(2), CYP2F1(3), CYP2J2(4), CYP3A4(1), CYP3A5(4), CYP3A7(6), CYP4B1(6), CYP4F8(1), CYP51A1(2), PON1(2)	8925210	106	59	102	36	27	21	13	25	20	0	0.719	1.000	1.000
333	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(2), ACAA2(2), ACAD8(2), ACAD9(4), ADH1A(2), ADH1B(6), ADH5(1), ADH6(2), ADH7(3), ADHFE1(1), AKR1B10(1), AKR1C4(3), AKR1D1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH7A1(2), ALDH9A1(2), BAAT(2), CEL(2), CYP27A1(4), CYP7A1(3), HADHB(2), HSD3B7(2), LIPA(5), RDH11(2), RDH12(2), RDH13(1), SLC27A5(7), SOAT1(3), SOAT2(2)	9556555	83	59	82	46	19	23	8	20	13	0	0.993	1.000	1.000
334	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(3), GTF2B(7), GTF2E1(3), GTF2E2(2), GTF2F1(1), GTF2H3(1), GTF2I(3), GTF2IRD1(3), STON1(5), TAF1(12), TAF10(1), TAF1L(9), TAF2(11), TAF4(1), TAF4B(4), TAF5(3), TAF5L(3), TAF6(2), TAF6L(1), TAF7(1), TAF7L(6), TAF9B(1), TBPL1(5), TBPL2(1)	11199812	89	58	86	50	15	29	15	17	11	2	0.983	1.000	1.000
335	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(15), BMPR1B(2), CCND2(1), CDKN1B(2), DAZL(1), DMC1(1), ESR2(3), FSHR(2), INHA(2), LHCGR(7), MLH1(4), MSH5(9), NCOR1(11), NR5A1(2), NRIP1(4), PGR(8), PTGER2(5), SMPD1(3), VDR(2), ZP2(3)	10279462	87	58	86	51	22	18	9	24	13	1	0.997	1.000	1.000
336	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(2), CDK5(1), CDK5R1(1), CFL1(3), LIMK1(2), MAP3K1(6), MYLK(4), NCF2(4), PAK1(4), PDGFRA(10), PIK3CA(10), PIK3R1(5), PLD1(6), PPP1R12B(5), RAC1(1), RALBP1(1), RPS6KB1(5), TRIO(12), VAV1(6), WASF1(2)	10535736	90	58	89	40	26	24	7	19	14	0	0.919	1.000	1.000
337	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(2), ABAT(3), ACADS(3), ACAT1(1), ACAT2(6), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(2), ECHS1(2), EHHADH(14), GAD1(5), GAD2(2), HADHA(3), HMGCL(1), L2HGDH(2), OXCT1(7), PDHA1(1), PDHA2(4), PDHB(2), SDHB(3), SDS(4)	7718308	81	57	80	49	20	15	12	26	8	0	0.998	1.000	1.000
338	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	29	B4GALT5(2), C1GALT1C1(1), GALNT1(4), GALNT11(3), GALNT12(3), GALNT13(7), GALNT14(3), GALNT3(3), GALNT4(7), GALNT5(6), GALNT6(4), GALNT8(6), GALNT9(3), GALNTL5(4), GCNT3(4), GCNT4(2), OGT(4), ST3GAL1(1), ST6GALNAC1(6), WBSCR17(7)	9624920	80	57	77	31	14	20	15	23	8	0	0.677	1.000	1.000
339	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(2), CHIA(2), CHIT1(9), CMAS(2), CTBS(3), CYB5R1(2), CYB5R3(3), GFPT1(2), GFPT2(2), GNE(6), GNPDA2(3), GNPNAT1(2), HEXA(2), HEXB(1), HK1(4), HK2(8), HK3(6), LHPP(1), MTMR1(2), MTMR2(3), MTMR6(5), NAGK(3), NANS(2), NPL(2), PGM3(6), PHPT1(1), UAP1(3)	8658425	87	57	82	42	18	21	9	26	13	0	0.956	1.000	1.000
340	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(9), CREBBP(12), DUSP1(1), EP300(7), IKBKB(6), IL1B(2), MAP2K6(1), MAP3K14(2), MAP3K7(3), MAPK11(4), MAPK14(4), MYD88(3), NFKB1(7), NFKBIA(2), NR3C1(4), RELA(4), TGFBR1(5), TGFBR2(1), TLR2(2), TNF(2)	8894036	81	57	80	38	14	21	10	23	13	0	0.973	1.000	1.000
341	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(3), CALM1(1), JUN(1), MAP2K1(5), MAP2K2(3), MAP2K4(4), MAP3K1(6), MAPK1(3), MAPK14(4), MAPK3(1), PAK1(4), PLCG1(10), PRKCA(2), PTK2B(8), RAC1(1), RAF1(2), SHC1(5), SOS1(10), SRC(2), SYT1(1)	8523583	76	57	76	30	19	21	8	12	15	1	0.895	1.000	1.000
342	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(3), ALDH4A1(4), CAD(7), CPS1(10), EPRS(7), GAD1(5), GAD2(2), GCLM(1), GFPT1(2), GLS(4), GLS2(3), GLUD1(3), GLUL(3), GMPS(3), GOT1(2), GOT2(2), GPT(5), GPT2(3), GSS(4), NADSYN1(4), PPAT(3), QARS(3)	9994593	83	56	83	43	23	22	5	21	11	1	0.991	1.000	1.000
343	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(19), APOA4(3), APOC2(1), APOC3(1), CETP(2), CYP7A1(3), DGAT1(2), HMGCR(5), LCAT(3), LDLR(5), LIPC(6), LPL(4), LRP1(19), SCARB1(2), SOAT1(3)	8102603	78	56	76	32	21	19	10	22	4	2	0.877	1.000	1.000
344	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(2), BCL2(1), BCR(4), FOS(2), JAK2(9), JUN(1), MAP2K1(5), MAP2K4(4), MAP3K1(6), MAPK3(1), MYC(2), PIK3CA(10), PIK3R1(5), RAF1(2), SOS1(10), STAT1(7), STAT5A(2), STAT5B(3)	8320312	76	55	75	21	16	20	9	17	13	1	0.318	1.000	1.000
345	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(3), CALCR(4), CALCRL(1), CD97(5), CRHR1(3), CRHR2(6), ELTD1(9), EMR1(10), EMR2(3), GHRHR(2), GIPR(3), GLP1R(2), GLP2R(6), GPR64(5), LPHN1(10), LPHN2(9), LPHN3(12), SCTR(1), VIPR1(2), VIPR2(4)	8425248	100	55	97	38	12	18	17	35	18	0	0.882	1.000	1.000
346	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	28	BAG4(5), BIRC2(6), BIRC3(6), CASP3(2), CASP8(3), CFLAR(2), FADD(2), JUN(1), MAP2K4(4), MAP3K3(2), MAP3K7(3), NFKB1(7), NFKB2(2), NFKBIA(2), NFKBIE(1), NFKBIL1(3), NR2C2(4), RALBP1(1), RIPK1(6), TNF(2), TNFAIP3(4), TNFRSF1A(2), TNFRSF1B(3)	8466660	73	55	73	28	19	16	6	20	12	0	0.830	1.000	1.000
347	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), CHUK(9), EGR2(3), EGR3(5), MAP3K1(6), MYC(2), NFATC1(3), NFATC2(4), NFKB1(7), NFKBIA(2), PLCG1(10), PPP3CA(6), PPP3CB(5), PPP3CC(1), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), RELA(4), SYT1(1), VIP(1), VIPR2(4)	8240184	83	55	83	37	18	21	7	20	15	2	0.966	1.000	1.000
348	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(3), ABP1(4), ACADL(6), ACADM(1), ACADSB(1), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(2), AOC2(3), AOC3(3), CNDP1(2), DPYD(17), ECHS1(2), EHHADH(14), GAD1(5), GAD2(2), HADHA(3), SDS(4), SMS(1), UPB1(1)	8608180	88	54	86	39	12	20	16	29	11	0	0.896	1.000	1.000
349	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(2), CREB1(1), MAP2K1(5), MAP2K2(3), MAP2K6(1), MAP3K1(6), MAPK1(3), MAPK14(4), MAPK3(1), NFKB1(7), PIK3CA(10), PIK3R1(5), RB1(19), RELA(4), SP1(2)	5928793	73	54	72	24	14	14	8	15	21	1	0.704	1.000	1.000
350	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(3), ABP1(4), ACADM(1), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH7A1(2), ALDH9A1(2), AOC2(3), AOC3(3), CNDP1(2), DPYD(17), ECHS1(2), EHHADH(14), GAD1(5), GAD2(2), HADHA(3), HIBCH(5), SMS(1), SRM(3), UPB1(1)	8005188	83	54	81	32	11	20	15	29	8	0	0.661	1.000	1.000
351	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(3), AGPAT2(1), AGPAT3(4), AGPAT4(1), AGPAT6(5), AGPS(3), CHPT1(3), ENPP2(7), ENPP6(2), PAFAH1B1(1), PAFAH1B2(3), PAFAH2(1), PLA2G12A(2), PLA2G12B(2), PLA2G1B(1), PLA2G2A(1), PLA2G2D(3), PLA2G2E(1), PLA2G2F(6), PLA2G3(4), PLA2G4A(6), PLA2G6(6), PLD1(6), PLD2(5), PPAP2A(3), PPAP2B(1), PPAP2C(4)	7093959	85	54	85	28	22	18	12	20	13	0	0.443	1.000	1.000
352	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	ARSB(1), FUCA1(2), FUCA2(1), GALNS(3), GBA(1), GLB1(6), GNS(2), GUSB(6), HEXA(2), HEXB(1), HGSNAT(3), HPSE(1), HPSE2(2), HYAL1(2), HYAL2(2), IDUA(4), LCT(7), MAN2B1(2), MAN2B2(7), MAN2C1(10), MANBA(2), NAGLU(4), NEU1(5), NEU2(3), NEU3(2), NEU4(3), SPAM1(5)	10641212	89	54	89	51	23	16	13	28	9	0	0.997	1.000	1.000
353	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(4), CS(1), DLAT(4), DLD(2), DLST(2), FH(4), IDH2(5), IDH3B(1), IDH3G(2), MDH1(1), MDH2(2), OGDH(4), PC(10), PDHA1(1), PDHA2(4), PDHB(2), PDHX(4), PDK1(1), PDK2(2), PDK3(3), PDK4(3), SDHA(5), SDHB(3), SUCLA2(3), SUCLG1(2), SUCLG2(2)	8580258	77	54	77	33	15	15	15	25	7	0	0.821	1.000	1.000
354	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(12), C5(9), C6(2), C7(3), ICAM1(2), IL1A(3), IL6(3), ITGA4(7), ITGAL(7), ITGB1(3), ITGB2(9), SELP(8), SELPLG(3), TNF(2), VCAM1(3)	7439472	76	54	73	45	13	19	12	21	11	0	0.997	1.000	1.000
355	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), DLG4(3), GRIN1(6), GRIN2A(6), GRIN2B(10), GRIN2C(4), GRIN2D(4), NOS1(15), PPP3CA(6), PPP3CB(5), PPP3CC(1), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(2), SYT1(1)	7713544	73	54	73	37	14	19	8	21	10	1	0.993	1.000	1.000
356	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(3), EPHB2(7), F2(2), F2RL1(1), F2RL3(1), JUN(1), MAP2K5(1), MAPK1(3), MAPK7(6), MYEF2(4), PLD1(6), PLD2(5), PLD3(5), PTK2(9), RAF1(2), RASAL1(8), SRC(2), TEC(2), VAV1(6)	8262317	75	54	75	26	18	17	10	24	6	0	0.596	1.000	1.000
357	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CARM1(2), CBS(5), CTH(3), HEMK1(5), LCMT1(2), LCMT2(4), MARS(7), MARS2(1), MAT1A(4), MAT2B(1), METTL2B(6), METTL6(1), PAPSS1(4), PAPSS2(5), PRMT3(2), PRMT5(4), PRMT6(4), PRMT7(1), PRMT8(3), SCLY(4), SEPHS1(2), SEPHS2(1), WBSCR22(1)	7465760	72	53	72	32	20	14	8	22	6	2	0.937	1.000	1.000
358	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	22	CHUK(9), FADD(2), IKBKB(6), IL1A(3), IL1R1(4), IRAK1(6), MAP3K1(6), MAP3K14(2), MAP3K7(3), MYD88(3), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(6), TLR4(3), TNF(2), TNFAIP3(4), TNFRSF1A(2), TNFRSF1B(3), TRAF6(1)	7532335	78	53	78	28	16	19	8	25	10	0	0.715	1.000	1.000
359	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(4), GTF2A1(3), GTF2B(7), GTF2E1(3), GTF2F1(1), HDAC3(2), NCOA1(6), NCOA2(10), NCOA3(13), NCOR2(11), POLR2A(10), RARA(2), RXRA(6)	7543692	78	53	77	47	21	15	10	22	10	0	0.998	1.000	1.000
360	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(5), ABAT(3), ADSL(1), ADSS(3), AGXT(5), AGXT2(3), ASL(2), ASNS(6), ASPA(1), CAD(7), CRAT(3), DARS(1), DDO(2), GAD1(5), GAD2(2), GOT1(2), GOT2(2), GPT(5), GPT2(3), PC(10)	7820641	71	52	71	34	18	21	6	21	5	0	0.974	1.000	1.000
361	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(3), AKR1D1(3), ARSB(1), ARSD(5), ARSE(2), CYP11B1(4), CYP11B2(9), HSD11B1(2), HSD17B2(1), HSD17B3(3), HSD3B1(1), STS(3), SULT1E1(1), SULT2A1(3), UGT1A1(1), UGT1A10(3), UGT1A3(2), UGT1A4(1), UGT1A5(13), UGT1A8(1), UGT1A9(1), UGT2B15(5), UGT2B4(5)	8165328	73	52	72	43	12	25	6	20	10	0	0.998	1.000	1.000
362	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	21	F10(3), F13B(2), F2(2), F5(18), F8(11), F9(1), FGA(9), FGB(2), FGG(4), LPA(10), PLAT(2), PLAU(6), PLG(1), SERPINB2(2), SERPINE1(4), SERPINF2(1), VWF(10)	10832946	88	52	84	55	14	28	15	19	12	0	0.999	1.000	1.000
363	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(8), AGT(2), EDN1(2), EDNRA(3), EDNRB(2), EGF(10), EGFR(7), FOS(2), JUN(1), MYC(2), NFKB1(7), PLCG1(10), PRKCA(2), RELA(4)	6099091	62	52	62	25	10	19	8	15	10	0	0.820	1.000	1.000
364	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOB(3), FBP1(2), FBP2(1), FPGT(4), GCK(3), GMDS(2), GMPPA(5), GMPPB(2), HK1(4), HK2(8), HK3(6), KHK(1), MPI(2), PFKFB1(4), PFKFB3(5), PFKFB4(3), PFKM(2), PFKP(6), PMM1(3), PMM2(1), SORD(4)	7291930	73	52	73	30	18	16	13	15	11	0	0.851	1.000	1.000
365	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(3), ACO1(3), ACO2(4), CLYBL(3), CS(1), DLD(2), DLST(2), FH(4), IDH1(7), IDH2(5), IDH3B(1), IDH3G(2), MDH1(1), MDH2(2), OGDH(4), OGDHL(2), PC(10), PCK1(6), SDHA(5), SDHB(3), SUCLA2(3), SUCLG1(2), SUCLG2(2)	8912494	77	52	75	35	10	13	20	26	8	0	0.927	1.000	1.000
366	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(4), ACY1(1), ADC(1), AGMAT(3), ALDH18A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH7A1(2), ALDH9A1(2), AMD1(3), AOC2(3), AOC3(3), ARG1(3), ARG2(2), ASL(2), ASS1(2), CPS1(10), GATM(6), MAOA(4), MAOB(3), NAGS(5), ODC1(3), OTC(3), SMS(1), SRM(3)	8847736	80	52	80	28	20	16	8	27	9	0	0.586	1.000	1.000
367	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(3), ACACA(10), ACADL(6), ACADM(1), ACADSB(1), ACAT1(1), ACAT2(6), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH6A1(6), ALDH9A1(2), ECHS1(2), EHHADH(14), HADHA(3), LDHA(1), LDHB(2), LDHC(2), MUT(4), PCCA(3), PCCB(5), SDS(4), SUCLA2(3), SUCLG1(2), SUCLG2(2)	9926571	97	52	97	57	20	23	14	25	15	0	0.995	1.000	1.000
368	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	CCNH(3), CDK7(1), ERCC3(4), GTF2B(7), GTF2E1(3), GTF2E2(2), ILK(1), MNAT1(1), POLR1A(10), POLR1B(3), POLR2A(10), POLR2B(8), POLR2C(1), POLR2E(2), POLR2G(2), POLR2H(1), POLR2I(2), POLR3B(4), POLR3D(3), POLR3E(2), POLR3K(1), TAF5(3), TAF6(2), TAF7(1)	10654172	77	52	77	53	21	17	8	19	12	0	1.000	1.000	1.000
369	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	33	DUSP1(1), GORASP1(1), MAP2K4(4), MAP2K7(2), MAPK1(3), MAPK10(4), MAPK11(4), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(1), MAPK8IP3(2), MAPK9(4), MAPKAPK5(4), NFKB1(7), NFKB2(2), NFKBIA(2), NFKBIE(1), NFKBIL1(3), PIK3CA(10), PIK3CD(5), PIK3R1(5), SYT1(1), TRAF3(1), TRAF5(2), TRAF6(1)	10663947	77	52	75	31	21	15	9	19	13	0	0.934	1.000	1.000
370	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(2), ACTN1(5), ACTN2(8), ACTN3(1), CAPN1(3), CAPNS1(1), ITGA1(7), ITGB1(3), ITGB3(3), PTK2(9), PXN(5), RAC1(1), SPTAN1(9), SRC(2), TLN1(12)	8685170	71	52	71	31	13	23	2	22	11	0	0.974	1.000	1.000
371	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(1), ALOX15(3), ALOX5(4), CYP2C18(4), CYP2C8(3), CYP2C9(4), CYP2E1(2), CYP2J2(4), CYP3A4(1), CYP3A43(3), CYP3A5(4), CYP3A7(6), HSD3B7(2), PLA2G12A(2), PLA2G12B(2), PLA2G1B(1), PLA2G2A(1), PLA2G2D(3), PLA2G2E(1), PLA2G2F(6), PLA2G3(4), PLA2G4A(6), PLA2G6(6), RDH11(2), RDH12(2), RDH13(1)	7322490	78	51	78	25	21	15	12	20	10	0	0.423	1.000	1.000
372	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(2), EIF2B5(5), EIF2S1(1), EIF2S2(1), EIF2S3(2), EIF4E(2), EIF4EBP1(1), GSK3B(6), IGF1(1), IGF1R(12), INPPL1(3), PDK2(2), PDPK1(2), PIK3CA(10), PIK3R1(5), PPP2CA(4), PTEN(11), RPS6(1), RPS6KB1(5)	6124579	76	51	75	23	15	18	9	20	13	1	0.397	1.000	1.000
373	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	25	ATF1(2), CASP2(1), CHUK(9), CRADD(1), IKBKB(6), JUN(1), LTA(2), MAP2K4(4), MAP2K6(1), MAP3K1(6), MAP3K14(2), MAP4K2(4), MAPK14(4), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(6), TANK(2), TNF(2), TNFRSF1A(2)	7492908	68	51	68	27	16	13	8	18	13	0	0.887	1.000	1.000
374	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(2), ARSB(1), ARSD(5), ARSE(2), ASAH1(4), GALC(6), GBA(1), GLA(1), GLB1(6), LCT(7), NEU1(5), NEU2(3), NEU3(2), NEU4(3), PPAP2A(3), PPAP2B(1), PPAP2C(4), SMPD1(3), SMPD2(2), SPTLC1(2), SPTLC2(4), UGCG(2)	7257556	69	50	68	36	15	21	11	18	4	0	0.954	1.000	1.000
375	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG5(3), ATG7(4), BECN1(4), GABARAP(1), GABARAPL1(1), IFNA13(1), IFNA14(2), IFNA16(2), IFNA17(6), IFNA2(2), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(5), IFNA8(2), IFNG(3), PIK3C3(2), PIK3R4(9), PRKAA1(4), PRKAA2(4), ULK1(8), ULK2(8)	6470076	77	50	75	32	16	12	6	30	12	1	0.923	1.000	1.000
376	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(7), CD4(3), CREBBP(12), CSK(2), GNAS(9), GNB1(4), GNGT1(1), HLA-DRB1(4), LCK(5), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PTPRC(9), ZAP70(3)	6905669	68	49	65	36	12	15	10	23	7	1	0.997	1.000	1.000
377	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(7), CD4(3), CREBBP(12), CSK(2), GNAS(9), GNB1(4), GNGT1(1), HLA-DRB1(4), LCK(5), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PTPRC(9), ZAP70(3)	6905669	68	49	65	36	12	15	10	23	7	1	0.997	1.000	1.000
378	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(2), BLVRA(2), CP(6), CPOX(3), EPRS(7), FECH(2), GUSB(6), HCCS(2), HMBS(3), HMOX1(1), HMOX2(2), PPOX(3), UGT1A1(1), UGT1A10(3), UGT1A3(2), UGT1A4(1), UGT1A5(13), UGT1A8(1), UGT1A9(1), UGT2B15(5), UGT2B4(5), UROS(3)	8156960	74	49	74	47	9	14	5	25	20	1	1.000	1.000	1.000
379	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	16	CHUK(9), CREBBP(12), EP300(7), FADD(2), HDAC3(2), IKBKB(6), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(6), TNF(2), TNFRSF1A(2), TNFRSF1B(3), TRAF6(1)	6872004	65	49	65	35	14	16	6	21	8	0	0.991	1.000	1.000
380	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(5), CARS(4), DARS(1), EPRS(7), FARS2(2), GARS(2), HARS(1), IARS(9), KARS(1), LARS(5), LARS2(2), MARS(7), MARS2(1), QARS(3), RARS(3), SARS(2), TARS(4), WARS(6), WARS2(1)	9536740	66	48	66	28	18	22	4	13	8	1	0.726	1.000	1.000
381	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(1), CR1(23), CR2(9), FCGR2B(3), HLA-DRB1(4), ICAM1(2), ITGAL(7), ITGB2(9), PTPRC(9)	5106644	67	48	61	28	13	15	11	15	13	0	0.827	1.000	1.000
382	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(3), ACO2(4), CS(1), DLD(2), DLST(2), FH(4), IDH1(7), IDH2(5), IDH3B(1), IDH3G(2), MDH1(1), MDH2(2), PC(10), PCK1(6), SDHA(5), SDHB(3), SUCLA2(3), SUCLG1(2), SUCLG2(2)	6188664	65	48	63	28	8	11	17	21	8	0	0.871	1.000	1.000
383	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(2), CREB1(1), MAPK1(3), MAPK3(1), MAPK7(6), MEF2A(4), MEF2C(3), MEF2D(1), NTRK1(5), PIK3CA(10), PIK3R1(5), PLCG1(10), RPS6KA1(4), SHC1(5)	5963318	60	48	59	20	14	12	10	16	8	0	0.623	1.000	1.000
384	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(5), AKT1(2), CALM1(1), GNAS(9), GNB1(4), GNGT1(1), NFKB1(7), NOS3(8), NPPA(1), NR3C1(4), PIK3CA(10), PIK3R1(5), RELA(4), SYT1(1)	5469860	62	48	58	20	12	13	8	24	5	0	0.655	1.000	1.000
385	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), DCXR(1), GUSB(6), RPE(1), UGDH(4), UGP2(2), UGT1A1(1), UGT1A10(3), UGT1A3(2), UGT1A4(1), UGT1A5(13), UGT1A8(1), UGT1A9(1), UGT2A1(5), UGT2A3(3), UGT2B10(2), UGT2B11(3), UGT2B15(5), UGT2B17(1), UGT2B28(13), UGT2B4(5), UGT2B7(5), XYLB(1)	7759244	81	48	76	46	9	23	7	26	16	0	1.000	1.000	1.000
386	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASNS(6), ASRGL1(2), CA1(1), CA12(4), CA13(1), CA2(2), CA3(2), CA4(2), CA5A(4), CA5B(2), CA6(4), CA8(3), CA9(3), CPS1(10), CTH(3), GLS(4), GLS2(3), GLUD1(3), GLUD2(3), GLUL(3), HAL(2)	6289484	68	48	67	27	15	16	7	19	11	0	0.766	1.000	1.000
387	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(2), FOS(2), IL2(1), IL2RA(2), IL2RB(3), IL2RG(1), JAK1(8), JAK3(5), JUN(1), LCK(5), MAP2K1(5), MAPK3(1), RAF1(2), SHC1(5), SOS1(10), STAT5A(2), STAT5B(3), SYK(4)	7213419	62	48	62	21	13	14	12	14	8	1	0.623	1.000	1.000
388	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(2), ADCY1(7), CCNB1(4), CDC25C(1), GNAI1(4), GNAS(9), GNB1(4), GNGT1(1), MAPK1(3), MAPK3(1), MYT1(6), PIN1(1), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), RPS6KA1(4), SRC(2)	6200802	58	48	56	24	15	12	5	19	6	1	0.897	1.000	1.000
389	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCR1(3), CCR2(4), CCR3(3), CCR5(2), CCR7(4), CD4(3), CSF2(2), CXCR3(1), CXCR4(2), IFNG(3), IFNGR1(5), IFNGR2(2), IL12A(6), IL12B(2), IL12RB1(5), IL12RB2(10), IL18R1(3), IL2(1), IL4(1), IL4R(4), TGFB1(1), TGFB2(4), TGFB3(3)	6061964	75	48	75	28	13	23	5	25	9	0	0.800	1.000	1.000
390	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(12), ASAH1(4), CAMP(1), CASP3(2), CERK(2), CREB1(1), CREB3(2), CREB5(5), EPHB2(7), FOS(2), ITPKA(1), ITPKB(2), JUN(1), MAP2K4(4), MAP2K7(2), MAPK1(3), MAPK10(4), MAPK8IP3(2), MAPK9(4)	8513509	61	48	61	38	15	13	6	17	9	1	0.998	1.000	1.000
391	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), CHUK(9), IFNG(3), IKBKB(6), IL2(1), IL4(1), JUN(1), MAP3K1(6), MAP3K5(6), MAP4K5(11), MAPK14(4), NFKB1(7), NFKBIA(2), RELA(4)	5940204	62	47	61	28	13	13	8	17	11	0	0.913	1.000	1.000
392	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(1), CSF1R(3), DDX20(8), E2F1(2), E2F4(2), ETS1(1), ETS2(2), ETV3(2), FOS(2), HDAC2(5), HDAC5(3), JUN(1), NCOR2(11), RBL1(6), RBL2(8), SIN3A(5), SIN3B(6)	8080093	68	47	68	29	19	14	11	15	9	0	0.907	1.000	1.000
393	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(5), DYRK1B(2), GLI2(11), GLI3(13), GSK3B(6), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), SHH(2), SUFU(4)	4897111	52	47	52	16	9	10	3	21	8	1	0.654	1.000	1.000
394	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(2), ACAA2(2), ADH1A(2), ADH1B(6), ADH6(2), ADH7(3), ADHFE1(1), AKR1C4(3), AKR1D1(3), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(2), BAAT(2), CEL(2), CYP27A1(4), CYP7A1(3), HADHB(2), SOAT2(2)	6951336	55	46	54	39	10	16	6	15	8	0	0.999	1.000	1.000
395	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	28	ANXA2(1), ANXA3(5), ANXA4(3), ANXA6(3), ANXA8(1), CYP11A1(2), EDN1(2), EDNRA(3), EDNRB(2), HPGD(3), HSD11B1(2), PLA2G4A(6), PRL(2), PTGDR(1), PTGER2(5), PTGER4(1), PTGFR(3), PTGIR(2), PTGIS(2), PTGS1(3), PTGS2(2), S100A6(1), TBXAS1(2)	6559210	57	46	57	36	8	14	7	23	5	0	1.000	1.000	1.000
396	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(2), AKT2(7), AKT3(4), CDKN1A(6), MAP2K1(5), MAP2K2(3), NGFR(1), NTRK1(5), PIK3CA(10), PIK3CD(5), SHC1(5), SOS1(10)	4995277	63	46	62	19	13	18	9	17	5	1	0.383	1.000	1.000
397	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(10), ARHGDIB(1), BIRC2(6), BIRC3(6), CASP1(4), CASP10(4), CASP2(1), CASP3(2), CASP4(4), CASP6(2), CASP7(4), CASP8(3), CASP9(1), DFFA(2), DFFB(3), GZMB(1), LMNA(3), LMNB1(5), LMNB2(4), PRF1(4)	5808238	70	45	70	27	15	15	2	24	14	0	0.828	1.000	1.000
398	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(4), FOS(2), JUN(1), MAP2K1(5), MAPK1(3), MAPK3(1), MYC(2), NFKB1(7), NFKBIA(2), PLCB1(11), PRKCA(2), RAF1(2), RELA(4), TNF(2)	4595009	48	45	48	15	11	11	7	13	6	0	0.441	1.000	1.000
399	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(3), F2(2), F2R(2), F3(2), F5(18), FGA(9), FGB(2), FGG(4), PROC(5), PROS1(4), SERPINC1(4), TFPI(4)	4989001	59	45	57	30	8	19	11	14	7	0	0.921	1.000	1.000
400	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(5), GABBR1(6), GPRC5A(4), GPRC5B(1), GPRC5C(1), GPRC5D(2), GRM1(8), GRM2(3), GRM3(6), GRM4(4), GRM5(5), GRM7(8), GRM8(9)	6211711	62	45	61	30	10	15	9	24	4	0	0.957	1.000	1.000
401	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(1), HLA-A(11), IL18(2), ITGB1(3), KLRC1(1), KLRC2(1), KLRC4(2), KLRD1(1), MAP2K1(5), MAPK3(1), PAK1(4), PIK3CA(10), PIK3R1(5), PTK2B(8), PTPN6(2), RAC1(1), SYK(4), VAV1(6)	5702449	68	45	65	20	13	13	8	19	15	0	0.553	1.000	1.000
402	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	CHUK(9), DUSP1(1), IKBKAP(16), IKBKB(6), LTA(2), MAP3K1(6), MAP3K14(2), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(6), TANK(2), TNFAIP3(4), TNFRSF1B(3), TRAF1(3), TRAF3(1)	6974069	74	45	73	25	15	12	13	24	10	0	0.580	1.000	1.000
403	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(7), AKT1(2), BAX(1), BCL2(1), CSF2RB(3), IGF1(1), IGF1R(12), IL3(2), KIT(10), KITLG(2), PIK3CA(10), PIK3R1(5), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), YWHAH(1)	6558597	66	44	65	21	11	9	11	22	12	1	0.556	1.000	1.000
404	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(8), CSF1R(3), EGF(10), EGFR(7), MET(2), PDGFRA(10), PRKCA(2), SH3GLB1(2), SH3GLB2(1), SH3KBP1(4), SRC(2)	5798394	51	44	51	17	13	13	6	10	9	0	0.428	1.000	1.000
405	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(1), BCL2(1), CASP8(3), FADD(2), MAP2K1(5), MAP2K4(4), MAP3K1(6), MAPK1(3), MAPK3(1), NFKB1(7), NSMAF(3), RAF1(2), RELA(4), RIPK1(6), SMPD1(3), TNFRSF1A(2)	6074650	53	44	52	23	15	12	6	11	9	0	0.856	1.000	1.000
406	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(10), EGFR(7), MAP2K1(5), MAP3K1(6), MAPK14(4), NCOR2(11), RARA(2), RXRA(6), THRA(1), THRB(1)	5245020	53	44	53	25	10	18	6	10	9	0	0.947	1.000	1.000
407	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(5), BAIAP2(3), CASP1(4), CASP3(2), CASP7(4), CASP8(3), INSR(11), ITCH(2), MAGI1(6), MAGI2(8), RERE(4), WWP1(6), WWP2(3)	7046080	61	44	59	40	19	7	4	22	8	1	0.999	1.000	1.000
408	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), ASNS(6), CA1(1), CA12(4), CA2(2), CA3(2), CA4(2), CA5A(4), CA5B(2), CA6(4), CA8(3), CA9(3), CPS1(10), CTH(3), GLS(4), GLS2(3), GLUD1(3), GLUL(3), HAL(2)	5631100	62	44	61	26	15	15	4	17	11	0	0.853	1.000	1.000
409	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	AKT1(2), AP2A1(5), AP2M1(1), ARF1(2), BTK(1), EEA1(4), GRASP(1), GSK3A(2), GSK3B(6), LYN(3), PDPK1(2), PFKL(3), PFKM(2), PFKP(6), PLCG1(10), PRKCZ(3), RAC1(1), RPS6KB1(5), VAV2(2)	7385525	61	44	61	34	15	21	2	15	8	0	0.997	1.000	1.000
410	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(1), ALDH18A1(1), ARG1(3), ARG2(2), ASL(2), CKB(1), CKM(2), CKMT1A(1), CKMT1B(1), CKMT2(5), CPS1(10), GAMT(1), GATM(6), GLUD1(3), NAGS(5), OAT(3), ODC1(3), OTC(3), PYCR1(2), SMS(1)	5608328	56	44	56	18	14	17	5	13	7	0	0.470	1.000	1.000
411	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	9	AKAP9(22), MAP2(17), PPP1CA(3), PPP2CA(4), PRKACB(3), PRKACG(1), PRKAR2A(3), PRKAR2B(1)	5030059	54	43	53	20	12	16	3	13	9	1	0.615	1.000	1.000
412	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	15	C1QA(2), C1R(1), C1S(4), C2(9), C3(12), C4A(2), C5(9), C6(2), C7(3), C8A(3), C8B(7), C9(3), MASP1(4)	10361122	61	43	61	42	14	16	7	17	7	0	1.000	1.000	1.000
413	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(10), BST1(2), CD38(2), ENPP1(4), ENPP3(8), NADK(4), NADSYN1(4), NMNAT1(2), NMNAT2(1), NMNAT3(2), NNT(4), NT5C(1), NT5C1A(2), NT5C1B(2), NT5C2(6), NUDT12(2)	6458955	56	43	56	24	9	18	7	17	4	1	0.784	1.000	1.000
414	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(8), ACE2(2), AGT(2), AGTR1(3), ANPEP(5), CPA3(4), CTSA(3), CTSG(1), ENPEP(5), LNPEP(10), MME(8), NLN(7), REN(1), THOP1(1)	6320735	60	43	60	21	13	18	3	12	13	1	0.748	1.000	1.000
415	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(7), IL22(2), IL22RA1(1), JAK1(8), JAK2(9), JAK3(5), STAT1(7), STAT3(5), STAT5A(2), STAT5B(3), TYK2(7)	5725032	56	43	56	19	13	17	6	13	7	0	0.697	1.000	1.000
416	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(2), CASP9(1), CDC42(2), CHUK(9), MAP2K1(5), MAPK3(1), NFKB1(7), PIK3CA(10), PIK3R1(5), RAC1(1), RAF1(2), RALA(2), RALBP1(1), RALGDS(4), RELA(4)	5881453	56	43	55	30	10	10	10	17	9	0	0.982	1.000	1.000
417	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(12), CDH1(4), CREBBP(12), EP300(7), MAP2K1(5), MAP3K7(3), MAPK3(1), SKIL(2), TGFB1(1), TGFB2(4), TGFB3(3), TGFBR1(5), TGFBR2(1)	7704147	60	43	60	44	8	24	8	12	7	1	0.999	1.000	1.000
418	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(2), CREB1(1), CREBBP(12), EP300(7), NCOA3(13), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), RARA(2), RXRA(6)	6193127	52	42	52	30	7	18	3	14	9	1	0.995	1.000	1.000
419	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(3), FBP1(2), FBP2(1), G6PD(3), GPI(2), H6PD(3), PFKL(3), PFKM(2), PFKP(6), PGD(2), PGM1(3), PGM3(6), PRPS1(1), PRPS1L1(2), PRPS2(3), RBKS(1), RPE(1), TALDO1(3), TKT(1), TKTL1(3), TKTL2(7)	7300686	58	42	58	39	14	15	2	20	7	0	1.000	1.000	1.000
420	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	37	ANPEP(5), G6PD(3), GCLM(1), GPX1(2), GPX2(2), GPX5(2), GPX6(2), GPX7(1), GSR(3), GSS(4), GSTA2(2), GSTA4(2), GSTA5(1), GSTK1(1), GSTM2(1), GSTM3(1), GSTM5(2), GSTO2(2), GSTP1(4), GSTT1(1), GSTT2(3), GSTZ1(2), IDH1(7), IDH2(5), MGST1(1), MGST3(1), OPLAH(6)	7048189	67	42	64	25	17	14	11	17	8	0	0.678	1.000	1.000
421	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(7), COL4A2(10), COL4A3(4), COL4A4(11), COL4A5(9), COL4A6(11), P4HB(1), SLC23A1(2), SLC23A2(2), SLC2A3(3)	7767579	60	42	58	43	12	14	11	19	4	0	0.957	1.000	1.000
422	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(2), CASP9(1), CHUK(9), GH1(2), GHR(8), NFKB1(7), NFKBIA(2), PDPK1(2), PIK3CA(10), PIK3R1(5), PPP2CA(4), RELA(4), YWHAH(1)	4413033	57	41	56	20	13	8	9	19	8	0	0.591	1.000	1.000
423	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	CHUK(9), DUSP1(1), IKBKAP(16), IKBKB(6), MAP3K1(6), MAP3K14(2), NFKB1(7), NFKBIA(2), RELA(4), TNFAIP3(4), TRAF3(1), TRAF6(1)	5729495	59	41	58	25	12	10	11	17	9	0	0.846	1.000	1.000
424	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(10), ACACB(14), FASN(18), MCAT(5), OLAH(4), OXSM(4)	4915137	55	41	55	28	18	11	10	9	7	0	0.929	1.000	1.000
425	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AMD1(3), BHMT(2), CBS(5), CTH(3), DNMT1(4), DNMT3A(4), DNMT3B(5), MARS(7), MARS2(1), MAT1A(4), MAT2B(1), MTAP(2), MTFMT(2), MTR(5), SRM(3), TAT(1)	6278341	52	41	52	19	9	11	4	17	11	0	0.745	1.000	1.000
426	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(2), EXT2(3), EXTL1(5), EXTL2(1), EXTL3(4), GLCE(3), HS2ST1(3), HS3ST1(1), HS3ST2(1), HS3ST3A1(3), HS3ST5(3), HS6ST1(1), HS6ST2(1), HS6ST3(4), NDST1(3), NDST2(3), NDST3(5), NDST4(7)	6280606	53	41	53	28	11	21	1	14	6	0	0.988	1.000	1.000
427	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(2), AGT(2), AGTR1(3), COL4A1(7), COL4A2(10), COL4A3(4), COL4A4(11), COL4A5(9), COL4A6(11), REN(1)	7733032	60	40	58	35	14	14	10	16	6	0	0.795	1.000	1.000
428	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(5), ACP2(1), ACP5(2), ACP6(2), ACPP(5), ACPT(1), ALPI(1), ALPL(3), ALPP(6), ALPPL2(3), CMBL(2), CYP3A4(1), CYP3A43(3), CYP3A5(4), CYP3A7(6), DHRS1(1), DHRS3(1), DHRS7(2), DHRSX(5), PON1(2), PON3(1)	5529279	57	40	54	25	15	6	6	20	10	0	0.952	1.000	1.000
429	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(1), B4GALT2(2), B4GALT3(2), B4GALT5(2), DDOST(1), DPAGT1(3), DPM1(1), FUT8(2), MAN1A1(3), MAN1B1(1), MGAT1(3), MGAT2(2), MGAT3(8), MGAT4A(2), MGAT5(5), RPN1(2), RPN2(2), ST6GAL1(2)	6003783	45	40	44	21	13	10	5	9	8	0	0.848	1.000	1.000
430	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(5), AP2A1(5), AP2M1(1), BIN1(4), CALM1(1), DNM1(3), EPN1(5), EPS15(2), NME1(1), PICALM(2), PPP3CA(6), PPP3CB(5), PPP3CC(1), SYNJ1(10), SYNJ2(2), SYT1(1)	6811679	54	40	53	26	9	11	8	19	7	0	0.921	1.000	1.000
431	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(10), BIRC2(6), BIRC3(6), CASP10(4), CASP3(2), CASP7(4), CASP8(3), CASP9(1), DFFA(2), DFFB(3), GZMB(1), PRF1(4), SCAP(4), SREBF1(4), SREBF2(7)	5596039	61	40	61	19	14	12	2	19	14	0	0.540	1.000	1.000
432	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(2), ACTR2(2), ACTR3(3), ARPC1A(2), ARPC1B(2), ARPC2(5), ARPC4(2), NCK1(1), NCKAP1(6), NTRK1(5), PIR(1), PSMA7(4), RAC1(1), WASF1(2), WASF2(2), WASF3(4), WASL(2)	4606524	46	39	45	25	11	16	6	7	6	0	0.937	1.000	1.000
433	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	16	C1QA(2), C1R(1), C1S(4), C2(9), C3(12), C4A(2), C5(9), C6(2), C7(3), C8A(3), C9(3), MASP1(4), MASP2(4), MBL2(1)	10564069	59	39	59	43	12	14	9	16	8	0	1.000	1.000	1.000
434	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(3), GABARAP(1), GABRA1(5), GABRA2(4), GABRA3(3), GABRA4(8), GABRA5(4), GABRA6(6), GPHN(9), SRC(2), UBQLN1(3)	3831143	48	39	48	22	4	11	2	21	10	0	0.968	1.000	1.000
435	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(4), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(5), ALDH3B2(4), ALDH9A1(2), AOC2(3), AOC3(3), ASPA(1), CNDP1(2), DDC(4), HAL(2), HARS(1), HDC(5), MAOA(4), MAOB(3), PRPS1(1), PRPS2(3)	7327611	61	39	59	31	13	7	7	24	9	1	0.979	1.000	1.000
436	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(1), B3GAT2(2), B3GAT3(1), CHPF(9), CHST11(1), CHST12(3), CHST13(2), CHST14(2), CHST3(5), CHST7(1), CHSY1(2), DSE(9), UST(3), XYLT1(7), XYLT2(3)	4120337	51	39	51	22	10	8	4	22	7	0	0.953	1.000	1.000
437	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(1), ACAT2(6), ACOT11(3), ACYP1(1), ACYP2(1), DHRS1(1), DHRS3(1), DHRS7(2), DHRSX(5), ECHS1(2), EHHADH(14), ESCO1(4), ESCO2(5), FN3K(1), GCDH(2), HADHA(3), NAT6(2), PNPLA3(3), SH3GLB1(2)	7699366	59	39	57	26	15	9	8	20	7	0	0.766	1.000	1.000
438	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(5), BCAT2(2), COASY(3), DPYD(17), ENPP1(4), ENPP3(8), ILVBL(1), PANK1(1), PANK2(2), PANK3(2), PANK4(2), PPCDC(2), PPCS(2), UPB1(1), VNN1(5)	5180014	57	39	54	21	13	15	10	16	3	0	0.540	1.000	1.000
439	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(10), POLR1B(3), POLR1C(1), POLR1D(1), POLR2A(10), POLR2B(8), POLR2C(1), POLR2E(2), POLR2G(2), POLR2H(1), POLR2I(2), POLR3A(9), POLR3B(4), POLR3K(1), ZNRD1(1)	6969907	56	39	56	35	19	12	4	13	8	0	0.998	1.000	1.000
440	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(1), CAMK1G(3), CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(1), ESRRA(4), HDAC5(3), MEF2A(4), MEF2C(3), MEF2D(1), PPARA(4), PPP3CA(6), PPP3CB(5), PPP3CC(1), SLC2A4(1), SYT1(1), YWHAH(1)	6374683	52	39	52	23	12	11	3	18	8	0	0.928	1.000	1.000
441	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(4), HLA-DRB1(4), IFNG(3), IFNGR1(5), IFNGR2(2), IL12A(6), IL12B(2), IL12RB1(5), IL12RB2(10), IL18(2), IL18R1(3), IL2(1), IL2RA(2), IL4(1), IL4R(4)	3796169	54	39	53	25	10	13	7	14	10	0	0.920	1.000	1.000
442	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(5), CD2(2), CD33(3), CD5(6), CSF2(2), IFNB1(1), IFNG(3), IL12A(6), IL12B(2), IL3(2), IL4(1), ITGAX(7), TLR2(2), TLR4(3), TLR7(7), TLR9(3)	5568150	55	38	54	22	12	8	11	17	7	0	0.691	1.000	1.000
443	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	FUCA1(2), FUCA2(1), GLB1(6), HEXA(2), HEXB(1), LCT(7), MAN2B1(2), MAN2B2(7), MAN2C1(10), MANBA(2), NEU1(5), NEU2(3), NEU3(2), NEU4(3)	6240739	53	38	53	21	15	13	7	15	3	0	0.713	1.000	1.000
444	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(2), ACAD9(4), ADH1A(2), ADH1B(6), ADH5(1), ADH6(2), ADH7(3), ADHFE1(1), DHRS1(1), DHRS3(1), DHRS7(2), DHRSX(5), ESCO1(4), ESCO2(5), NAT6(2), PNPLA3(3), SH3GLB1(2)	7401227	46	38	44	30	12	12	3	8	11	0	0.996	1.000	1.000
445	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(2), ITGA4(7), ITGAL(7), ITGAM(7), ITGB1(3), ITGB2(9), PECAM1(1), SELE(2), SELL(2), SELP(8)	4894686	51	38	48	25	13	11	7	12	8	0	0.937	1.000	1.000
446	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(6), ARHGEF1(3), GNA12(1), GNA13(2), GNB1(4), GNGT1(1), MYLK(4), PLCB1(11), PPP1R12B(5), PRKCA(2), ROCK1(7)	6210960	46	38	46	18	7	14	3	12	10	0	0.821	1.000	1.000
447	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(2), CYB5R3(3), GCK(3), GFPT1(2), GNE(6), GNPDA2(3), HEXA(2), HEXB(1), HK1(4), HK2(8), HK3(6), PGM3(6), UAP1(3)	5158553	49	37	49	28	13	10	7	14	5	0	0.969	1.000	1.000
448	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM1(1), CDKN1A(6), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), PLCG1(10), PPP3CA(6), PPP3CB(5), PPP3CC(1), PRKCA(2), SP1(2), SP3(3), SYT1(1)	6021641	53	37	53	22	11	15	3	16	8	0	0.849	1.000	1.000
449	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(7), GNAS(9), GNB1(4), GNGT1(1), PPP2CA(4), PRKAA1(4), PRKAA2(4), PRKAB1(1), PRKAB2(1), PRKACB(3), PRKACG(1), PRKAG2(3), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1)	4639162	47	37	45	17	12	10	4	15	5	1	0.784	1.000	1.000
450	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(5), BCAT2(2), IARS(9), IARS2(2), ILVBL(1), LARS(5), LARS2(2), PDHA1(1), PDHA2(4), PDHB(2), VARS(2), VARS2(12)	5578256	47	37	47	28	16	9	6	12	3	1	0.973	1.000	1.000
451	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(5), AMT(1), ATIC(1), FTCD(5), GART(10), MTFMT(2), MTHFD1(8), MTHFD1L(5), MTHFD2(1), MTHFR(4), MTR(5), SHMT1(4), SHMT2(2)	5747412	53	37	53	19	18	11	3	14	7	0	0.453	1.000	1.000
452	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(3), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH7A1(2), ALDH9A1(2), CYP2C9(4), DHRS1(1), DHRS3(1), DHRS7(2), DHRSX(5), ECHS1(2), EHHADH(14), ESCO1(4), ESCO2(5), HADHA(3), NAT6(2), PNPLA3(3), SH3GLB1(2)	9199499	65	37	63	26	18	12	8	22	5	0	0.600	1.000	1.000
453	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(1), MRPL13(4), MRPS7(1), RPL10A(2), RPL10L(1), RPL11(1), RPL13(2), RPL18(3), RPL18A(1), RPL23A(1), RPL27(1), RPL29(1), RPL3(2), RPL37(1), RPL38(1), RPL3L(1), RPL41(1), RPL6(2), RPL9(1), RPS10(1), RPS13(2), RPS15A(1), RPS18(1), RPS2(1), RPS23(1), RPS24(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(2), RPS6(1), RPS9(2)	6435858	45	37	45	19	11	11	4	13	6	0	0.893	1.000	1.000
454	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(3), CSF1(1), CSF2(2), HLA-DRB1(4), IFNB1(1), IFNG(3), IL12A(6), IL12B(2), IL1A(3), IL2(1), IL3(2), IL4(1), IL6(3), IL7(2), LTA(2), PDGFA(2), TGFB1(1), TGFB2(4), TGFB3(3), TNF(2)	4121889	48	37	47	24	4	10	12	18	4	0	0.951	1.000	1.000
455	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(12), EP300(7), LPL(4), NCOA1(6), NCOA2(10), PPARG(1), RXRA(6)	5486050	46	37	45	23	9	16	6	12	3	0	0.909	1.000	1.000
456	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(7), ADRB2(5), CFTR(12), GNAS(9), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), SLC9A3R1(1)	3921247	43	36	41	15	7	8	6	15	6	1	0.814	1.000	1.000
457	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(4), POLD1(5), POLE(9), POLG(7), POLL(1), POLQ(18)	4996065	44	36	44	15	12	12	4	10	6	0	0.593	1.000	1.000
458	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(2), CHPT1(3), HEMK1(5), LCMT1(2), LCMT2(4), METTL2B(6), METTL6(1), PCYT1A(4), PCYT1B(2), PRMT3(2), PRMT5(4), PRMT6(4), PRMT7(1), PRMT8(3), WBSCR22(1)	4166822	44	36	44	20	14	7	7	11	3	2	0.902	1.000	1.000
459	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(1), GALNS(3), GLB1(6), GNS(2), GUSB(6), HEXA(2), HEXB(1), HGSNAT(3), HPSE(1), HPSE2(2), HYAL1(2), HYAL2(2), IDUA(4), LCT(7), NAGLU(4), SPAM1(5)	6283076	51	36	51	37	12	4	10	18	7	0	0.999	1.000	1.000
460	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1L(2), GOSR1(3), GOSR2(4), SNAP25(2), SNAP29(1), STX10(1), STX12(4), STX16(1), STX18(2), STX19(4), STX2(4), STX3(3), STX4(1), STX5(2), STX6(1), TSNARE1(9), USE1(2), VAMP1(1), VAMP3(1), VAMP8(1), VTI1A(2), YKT6(2)	5101727	53	36	53	18	14	12	7	15	5	0	0.617	1.000	1.000
461	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(7), ABCC2(6), ABCG2(5), BCHE(4), CES1(3), CES2(1), CYP3A4(1), CYP3A5(4), UGT1A1(1), UGT1A10(3), UGT1A3(2), UGT1A4(1), UGT1A5(13), UGT1A8(1), UGT1A9(1)	6899267	53	36	53	32	8	17	5	14	9	0	0.995	1.000	1.000
462	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(11), ABCB11(8), ABCB4(6), ABCC1(7), ABCC3(10), GSTP1(4)	4362727	46	36	45	18	3	14	7	17	5	0	0.736	1.000	1.000
463	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(1), CDK5R1(1), DRD2(2), GRM1(8), PLCB1(11), PPP1CA(3), PPP1R1B(2), PPP2CA(4), PPP3CA(6), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1)	4800662	47	35	47	16	15	8	4	14	5	1	0.626	1.000	1.000
464	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	13	C1QA(2), C1R(1), C1S(4), C2(9), C3(12), C4A(2), C5(9), C6(2), C7(3), C8A(3), C9(3)	9379472	50	35	50	40	9	11	7	16	7	0	1.000	1.000	1.000
465	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(2), EPHA4(3), EPHB1(6), FYN(2), ITGA1(7), ITGB1(3), L1CAM(5), LYN(3), SELP(8)	4720951	39	35	38	25	7	8	6	15	3	0	0.992	1.000	1.000
466	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(3), F13A1(4), F2(2), F2R(2), FGA(9), FGB(2), FGG(4), PLAT(2), PLAU(6), PLG(1), SERPINB2(2), SERPINE1(4)	4014065	41	35	39	17	8	9	8	7	9	0	0.801	1.000	1.000
467	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(1), CYP51A1(2), DHCR24(2), DHCR7(1), FDFT1(1), FDPS(3), GGCX(5), GGPS1(2), HMGCR(5), HSD17B7(2), IDI1(2), IDI2(1), LSS(3), MVD(2), MVK(1), NQO1(2), NSDHL(2), PMVK(3), SQLE(3), TM7SF2(1), VKORC1(1)	5851904	45	35	43	19	9	8	6	13	8	1	0.896	1.000	1.000
468	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(2), DHRS1(1), DHRS3(1), DHRS7(2), DHRSX(5), HEMK1(5), LCMT1(2), LCMT2(4), METTL2B(6), METTL6(1), PRMT3(2), PRMT5(4), PRMT6(4), PRMT7(1), PRMT8(3), WBSCR22(1)	4437675	44	35	42	16	19	6	6	10	1	2	0.624	1.000	1.000
469	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(2), IL2RG(1), IL4(1), IL4R(4), IRS1(4), JAK1(8), JAK3(5), RPS6KB1(5), SHC1(5), STAT6(6)	4410993	41	35	41	18	8	12	5	9	7	0	0.940	1.000	1.000
470	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(2), ACHE(2), CHAT(5), COMT(1), DBH(2), DDC(4), GAD1(5), GAD2(2), HDC(5), MAOA(4), PAH(1), TH(3), TPH1(3)	4245899	39	34	39	22	12	6	3	13	5	0	0.989	1.000	1.000
471	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(4), KHK(1), LCT(7), MPI(2), PGM1(3), PYGL(8), PYGM(9), TREH(5)	4164452	39	34	37	14	11	7	7	8	6	0	0.572	1.000	1.000
472	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(5), G6PD(3), GCLM(1), GPX1(2), GPX2(2), GPX5(2), GSS(4), GSTA2(2), GSTA4(2), GSTM2(1), GSTM3(1), GSTM5(2), GSTO2(2), GSTP1(4), GSTT1(1), GSTT2(3), GSTZ1(2), IDH1(7), IDH2(5), MGST1(1), MGST3(1), PGD(2)	5788150	55	34	52	23	16	13	10	10	6	0	0.720	1.000	1.000
473	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(3), B4GALNT1(4), GLB1(6), HEXA(2), HEXB(1), LCT(7), SLC33A1(3), ST3GAL1(1), ST3GAL5(2), ST6GALNAC3(4), ST6GALNAC4(1), ST6GALNAC5(3), ST6GALNAC6(1), ST8SIA1(4), ST8SIA5(1)	4885381	43	34	43	19	7	11	7	13	5	0	0.799	1.000	1.000
474	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(5), ACP2(1), ACP5(2), ACP6(2), ACPP(5), ACPT(1), ENPP1(4), ENPP3(8), FLAD1(4), LHPP(1), MTMR1(2), MTMR2(3), MTMR6(5), PHPT1(1), RFK(1), TYR(6)	4550331	51	34	51	23	6	11	8	21	5	0	0.937	1.000	1.000
475	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(2), ACOX1(6), ACOX3(7), ELOVL2(4), ELOVL5(1), FADS1(1), FADS2(1), FASN(18), HADHA(3), PECR(4), SCD(2)	4581406	49	34	48	24	14	8	8	11	8	0	0.912	1.000	1.000
476	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), HMOX1(1), IL10RA(7), IL10RB(2), IL1A(3), IL6(3), JAK1(8), STAT1(7), STAT3(5), STAT5A(2), TNF(2)	3701416	42	34	42	16	9	9	4	16	4	0	0.883	1.000	1.000
477	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(5), AMT(1), ATIC(1), ATP6V0C(1), GART(10), MTHFD1(8), MTHFD1L(5), MTHFD2(1), MTHFR(4), MTR(5), SHMT1(4), SHMT2(2)	5364059	47	34	47	17	17	10	3	13	4	0	0.385	1.000	1.000
478	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(8), JAK2(9), JAK3(5), MAPK1(3), MAPK3(1), STAT3(5), TYK2(7)	3619958	38	34	38	11	8	13	5	7	5	0	0.457	1.000	1.000
479	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(3), ABP1(4), AOC2(3), AOC3(3), CES1(3), DDHD1(5), ESCO1(4), ESCO2(5), LIPA(5), NAT6(2), PLA1A(3), PNPLA3(3), PPME1(2), PRDX6(1), SH3GLB1(2)	7586012	48	33	48	18	8	11	7	18	4	0	0.534	1.000	1.000
480	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(3), CLOCK(4), CRY1(5), CSNK1E(3), NPAS2(7), NR1D1(3), PER1(4), PER2(7), PER3(4)	5118510	40	33	39	21	8	16	2	8	6	0	0.964	1.000	1.000
481	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	BHMT(2), CBS(5), CTH(3), DNMT1(4), DNMT3A(4), DNMT3B(5), MARS(7), MARS2(1), MAT1A(4), MAT2B(1), MTR(5)	5260142	41	33	41	18	6	10	1	16	8	0	0.939	1.000	1.000
482	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(6), ACADM(1), ACADS(3), ACADVL(3), ACSL1(3), ACSL3(3), ACSL4(2), CPT1A(6), CPT2(1), EHHADH(14), HADHA(3), PECR(4), SCP2(2), SLC25A20(1)	5013835	52	33	52	24	7	10	9	19	7	0	0.863	1.000	1.000
483	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	FUCA1(2), FUCA2(1), GLB1(6), HEXA(2), HEXB(1), LCT(7), MAN2C1(10), MANBA(2), NEU1(5), NEU2(3), NEU3(2), NEU4(3)	5080133	44	33	44	17	11	12	7	13	1	0	0.586	1.000	1.000
484	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(3), FBP1(2), FBP2(1), G6PD(3), GPI(2), H6PD(3), PFKM(2), PFKP(6), PGD(2), PGM1(3), PGM3(6), PRPS1(1), PRPS1L1(2), PRPS2(3), RBKS(1), RPE(1), TAL1(1), TALDO1(3), TKT(1)	6025550	46	33	46	34	13	11	0	15	7	0	1.000	1.000	1.000
485	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(7), ADRB2(5), GNAS(9), PLCE1(14), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1)	4449460	44	33	42	16	10	8	7	15	3	1	0.738	1.000	1.000
486	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(2), IL6(3), IL6R(1), JAK1(8), JAK2(9), JAK3(5), PTPRU(3), SRC(2), STAT3(5)	4635544	38	33	38	18	3	13	6	9	7	0	0.954	1.000	1.000
487	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(15), CDC25A(2), CDC25B(4), CDC25C(1), CHEK1(7), MYT1(6), WEE1(4), YWHAH(1)	4140624	40	32	40	17	8	8	2	17	5	0	0.867	1.000	1.000
488	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(3), HK1(4), HK2(8), HK3(6), IMPA1(3), IMPA2(3), PGM1(3), PGM3(6), TGDS(1)	3566411	37	32	37	19	8	7	5	13	4	0	0.948	1.000	1.000
489	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(3), FBP1(2), FBP2(1), GOT1(2), GOT2(2), GPT(5), GPT2(3), MDH1(1), MDH2(2), ME1(1), ME3(1), PGK1(2), PGK2(2), PKLR(1), RPE(1), TKT(1), TKTL1(3), TKTL2(7)	6058883	40	32	40	28	10	8	5	14	3	0	0.997	1.000	1.000
490	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(2), ITGA4(7), ITGAL(7), ITGB1(3), ITGB2(9), PECAM1(1), SELE(2), SELL(2)	3677873	36	32	34	17	9	10	2	8	7	0	0.913	1.000	1.000
491	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(8), CALM1(1), CAPN2(1), CAPNS1(1), EP300(7), HDAC2(5), MEF2D(1), NFATC1(3), NFATC2(4), PPP3CA(6), PPP3CB(5), PPP3CC(1), PRKCA(2), SYT1(1)	7198788	46	32	46	24	8	11	4	16	7	0	0.970	1.000	1.000
492	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(4), GALNT3(3), GALNT4(7), GALNT6(4), GALNT8(6), GALNT9(3), ST3GAL1(1), ST3GAL4(1), WBSCR17(7)	4386334	36	32	35	18	7	6	5	14	4	0	0.915	1.000	1.000
493	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(5), IFNB1(1), JAK1(8), PTPRU(3), STAT1(7), STAT2(6), TYK2(7)	3748636	37	32	37	18	10	8	4	10	5	0	0.965	1.000	1.000
494	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD80(1), CD86(4), CTLA4(3), HLA-DRB1(4), IL2(1), ITK(2), LCK(5), PIK3CA(10), PIK3R1(5), PTPN11(2)	3839086	37	31	34	22	3	10	9	11	4	0	0.989	1.000	1.000
495	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(3), ATP6V1D(2), ATP6V1F(2), ATP6V1G3(1), ATP6V1H(2), FDXR(3), SHMT1(4)	4819456	42	31	42	23	12	6	3	13	8	0	0.985	1.000	1.000
496	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(9), MAP3K14(2), MAPK14(4), NFKB1(7), RELA(4), TNFRSF13B(1), TNFRSF17(1), TNFSF13(2), TNFSF13B(2), TRAF3(1), TRAF5(2), TRAF6(1)	4325042	36	31	35	19	6	7	9	6	8	0	0.946	1.000	1.000
497	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), GZMB(1), HLA-A(11), ICAM1(2), ITGAL(7), ITGB2(9), PRF1(4)	2557223	35	30	33	11	6	8	2	12	7	0	0.674	1.000	1.000
498	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(10), ARHGAP5(6), ARHGDIB(1), CASP1(4), CASP10(4), CASP3(2), CASP8(3), CASP9(1), GZMB(1), JUN(1), PRF1(4)	3794258	37	30	37	20	6	7	1	17	6	0	0.972	1.000	1.000
499	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(9), EIF2AK4(7), EIF2B5(5), EIF2S1(1), EIF2S2(1), EIF2S3(2), EIF5(2), GSK3B(6), PPP1CA(3)	3444865	36	30	35	16	10	11	2	9	4	0	0.755	1.000	1.000
500	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(5), IFNAR2(1), IFNB1(1), JAK1(8), STAT1(7), STAT2(6), TYK2(7)	3265249	35	30	35	15	9	7	3	10	6	0	0.909	1.000	1.000
501	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(10), CPT1A(6), LEP(1), LEPR(7), PRKAA1(4), PRKAA2(4), PRKAB1(1), PRKAB2(1), PRKAG2(3)	4309519	37	30	37	21	12	8	3	9	5	0	0.956	1.000	1.000
502	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(2), IFNG(3), IFNGR1(5), JAK1(8), JAK2(9), PLA2G2A(1), PTPRU(3), STAT1(7)	3439468	38	30	38	16	5	12	3	10	8	0	0.922	1.000	1.000
503	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(3), ATP6V1D(2), ATP6V1F(2), ATP6V1G3(1), ATP6V1H(2), SHMT1(4)	4542657	39	29	39	23	11	5	3	12	8	0	0.992	1.000	1.000
504	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(1), CCR5(2), CXCL12(2), CXCR4(2), FOS(2), JUN(1), MAPK14(4), PLCG1(10), PRKCA(2), PTK2B(8), SYT1(1)	4043419	35	29	35	15	9	9	3	4	10	0	0.936	1.000	1.000
505	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(4), EGF(10), EGFR(7), HGS(10), TF(3), TFRC(1)	3819960	35	29	35	22	2	9	1	11	12	0	0.998	1.000	1.000
506	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(9), ERBB4(9), NRG2(3), NRG3(7), PRKCA(2), PSEN1(2)	2705570	32	29	32	11	7	7	3	12	2	1	0.640	1.000	1.000
507	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(2), CDC34(1), CUL1(3), E2F1(2), FBXW7(3), RB1(19), TFDP1(3)	2542700	33	29	33	11	3	5	1	6	17	1	0.907	1.000	1.000
508	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(3), ATP6V1D(2), ATP6V1F(2), ATP6V1G3(1), ATP6V1H(2), SHMT1(4)	4542657	39	29	39	23	11	5	3	12	8	0	0.992	1.000	1.000
509	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(4), CARS2(2), CDO1(1), CTH(3), GOT1(2), GOT2(2), LDHA(1), LDHAL6A(2), LDHAL6B(7), LDHB(2), LDHC(2), SDS(4), SULT1C2(2), SULT1C4(2)	3755596	36	29	35	22	9	14	1	9	3	0	0.985	1.000	1.000
510	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	14	BPNT1(2), CHST11(1), CHST12(3), CHST13(2), PAPSS1(4), PAPSS2(5), SULT1A1(4), SULT1A2(4), SULT1E1(1), SULT2A1(3), SULT2B1(3), SUOX(4)	3449587	36	29	33	10	11	6	3	11	5	0	0.574	1.000	1.000
511	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(1), ADSS(3), HPRT1(1), IMPDH1(2), MTHFD2(1), POLB(4), POLD1(5), POLG(7), PRPS2(3), RRM1(5), SRM(3)	3861411	35	29	35	12	8	11	2	10	4	0	0.586	1.000	1.000
512	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), DCXR(1), GUSB(6), RPE(1), UCHL1(1), UCHL3(1), UGDH(4), UGT1A1(1), UGT1A10(3), UGT1A3(2), UGT1A4(1), UGT1A5(13), UGT1A8(1), UGT1A9(1), UGT2B15(5), UGT2B4(5)	5206071	48	29	48	33	7	15	3	12	11	0	1.000	1.000	1.000
513	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(8), CD44(3), CSF1(1), FCGR3A(1), IL1B(2), IL6R(1), SELL(2), SPN(3), TGFB1(1), TGFB2(4), TNF(2), TNFRSF1A(2), TNFRSF1B(3), TNFRSF8(3), TNFSF8(1)	4179333	37	29	37	16	7	10	3	11	6	0	0.898	1.000	1.000
514	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(5), CTH(3), MARS(7), MARS2(1), MAT1A(4), MAT2B(1), PAPSS1(4), PAPSS2(5), SCLY(4), SEPHS1(2)	3755555	36	29	36	17	7	9	1	14	5	0	0.949	1.000	1.000
515	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(3), HK1(4), HK2(8), HK3(6), IMPA1(3), PGM1(3), PGM3(6), TGDS(1)	3153563	34	29	34	16	7	7	5	11	4	0	0.878	1.000	1.000
516	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD4(3), ICAM1(2), ITGAL(7), ITGB2(9), PTPRC(9)	3322677	32	29	31	14	9	12	2	6	3	0	0.847	1.000	1.000
517	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(3), ATP6V1D(2), ATP6V1F(2), ATP6V1G3(1), ATP6V1H(2), SHMT1(4)	4542657	39	29	39	23	11	5	3	12	8	0	0.992	1.000	1.000
518	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(2), CASP7(4), DFFA(2), DFFB(3), ENDOG(2), GZMB(1), HMGB2(1), TOP2A(9), TOP2B(10)	3187130	34	28	34	16	3	6	6	14	5	0	0.921	1.000	1.000
519	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(1), ALOX15(3), ALOX15B(4), ALOX5(4), DPEP1(1), LTA4H(5), PLA2G2A(1), PLA2G6(6), PTGES(1), PTGIS(2), PTGS1(3), PTGS2(2), TBXAS1(2)	4688450	35	28	35	24	11	7	1	11	5	0	1.000	1.000	1.000
520	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(1), GALNS(3), GLB1(6), GNS(2), GUSB(6), HEXA(2), HEXB(1), IDUA(4), LCT(7), NAGLU(4)	4358461	36	28	36	29	10	2	7	11	6	0	0.999	1.000	1.000
521	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(2), ASPH(4), COPS5(2), CREB1(1), EDN1(2), EP300(7), HIF1A(3), JUN(1), LDHA(1), NOS3(8), P4HB(1), VHL(1)	5089656	33	28	32	13	4	9	3	12	5	0	0.793	1.000	1.000
522	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP2A13(4), CYP2A6(6), CYP2A7(12), NAT2(3), XDH(13)	2415031	38	28	35	11	7	10	6	10	5	0	0.590	1.000	1.000
523	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(1), B3GNT2(2), B3GNT4(1), B4GALT2(2), B4GALT3(2), B4GALT4(1), FUT1(2), FUT2(1), FUT3(3), FUT5(4), FUT6(3), FUT7(2), FUT9(2), GCNT2(7), ST3GAL6(3), ST8SIA1(4)	4698173	40	28	38	15	9	8	7	11	5	0	0.723	1.000	1.000
524	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(10), CD38(2), ENPP1(4), ENPP3(8), NADSYN1(4), NMNAT1(2), NMNAT2(1), NNT(4), NT5C(1)	4388854	36	28	36	15	4	14	2	13	2	1	0.760	1.000	1.000
525	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(12), EP300(7), ESR1(4), MAPK1(3), MAPK3(1), PELP1(8), SRC(2)	4503533	37	28	37	18	7	12	4	8	6	0	0.893	1.000	1.000
526	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(4), ESR2(3), ITPKA(1), PDE1A(2), PDE1B(3), PLCB1(11), PLCB2(4), PRL(2), TRH(1), VIP(1)	3320385	32	28	32	21	7	8	3	8	6	0	0.994	1.000	1.000
527	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(3), CREBBP(12), DFFA(2), DFFB(3), GZMA(3), GZMB(1), HMGB2(1), NME1(1), PRF1(4)	3189752	30	28	30	16	4	8	4	9	5	0	0.960	1.000	1.000
528	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD8A(1), ICAM1(2), ITGAL(7), ITGB2(9), PTPRC(9)	3142804	30	28	29	11	10	10	2	5	3	0	0.652	1.000	1.000
529	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(2), DHCR7(1), FDFT1(1), FDPS(3), HMGCR(5), HMGCS1(4), IDI1(2), LSS(3), MVD(2), MVK(1), NSDHL(2), PMVK(3), SQLE(3)	3982693	32	27	32	14	3	7	4	13	4	1	0.882	1.000	1.000
530	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(6), ADH5(1), ADH6(2), ADH7(3), ADHFE1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH7A1(2), ALDH9A1(2)	3999194	29	27	29	27	6	5	2	7	9	0	1.000	1.000	1.000
531	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(3), ACO1(3), ACO2(4), ACSS1(2), ACSS2(3), FH(4), IDH1(7), IDH2(5), MDH1(1), MDH2(2), SUCLA2(3)	3988208	37	27	35	14	5	3	11	14	4	0	0.698	1.000	1.000
532	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(3), IFNGR1(5), IFNGR2(2), JAK1(8), JAK2(9), STAT1(7)	2464354	34	27	34	11	5	12	2	8	7	0	0.645	1.000	1.000
533	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(2), ECHS1(2), EHHADH(14), HADHA(3), SDS(4)	3647440	39	27	39	19	7	7	6	15	4	0	0.897	1.000	1.000
534	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(2), ITGAL(7), ITGAM(7), ITGB2(9), PECAM1(1), SELE(2), SELL(2)	3225480	33	27	32	13	10	10	2	6	5	0	0.810	1.000	1.000
535	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(2), JAK1(8), JAK2(9), JAK3(5), PIAS1(1), PTPRU(3), SOAT1(3)	4237196	31	27	31	22	4	11	4	5	7	0	0.999	1.000	1.000
536	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(3), FBP1(2), FBP2(1), GOT1(2), GOT2(2), GPT(5), GPT2(3), MDH1(1), MDH2(2), ME1(1), ME2(5), ME3(1), PGK1(2), PKLR(1), RPE(1), TKT(1)	5428261	33	26	32	25	9	5	6	10	3	0	0.997	1.000	1.000
537	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(2), ACAA2(2), ACAT1(1), ACAT2(6), ECHS1(2), EHHADH(14), HADHA(3), HADHB(2), SDS(4)	2545121	36	26	36	16	7	8	6	11	4	0	0.665	1.000	1.000
538	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	8	GABRA1(5), GABRA2(4), GABRA3(3), GABRA4(8), GABRA5(4), GABRA6(6), GPX1(2)	1966853	32	26	32	13	1	7	4	13	7	0	0.867	1.000	1.000
539	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(2), ANKRD1(1), ATF3(2), DUSP14(1), EIF4E(2), EIF4EBP1(1), HBEGF(1), IFNG(3), IFRD1(3), IL18(2), IL1A(3), IL1R1(4), JUND(2), MYOG(1), NR4A3(3), WDR1(2)	3309851	33	26	32	19	6	6	3	9	9	0	0.983	1.000	1.000
540	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(7), NFKBIA(2), PLCB1(11), PRKCA(2), RELA(4)	2506940	26	26	26	10	4	6	2	9	5	0	0.793	1.000	1.000
541	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(2), PSMA2(1), PSMA4(3), PSMA5(1), PSMA6(1), PSMA7(4), PSMB1(2), PSMB2(1), PSMB3(1), PSMB5(3), PSMB6(1), PSMB7(2), PSMD14(3), RPN1(2), RPN2(2), UBE3A(4)	3987432	33	26	33	12	6	7	5	11	4	0	0.633	1.000	1.000
542	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(3), POLR2A(10), POLR2B(8), POLR2C(1), POLR2E(2), POLR2G(2), POLR2H(1), POLR2I(2), POLRMT(1)	4005828	30	26	30	18	8	7	0	8	7	0	0.990	1.000	1.000
543	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(12), C5(9), C6(2), C7(3), C8A(3), C9(3)	3838899	32	25	32	30	5	8	4	9	6	0	1.000	1.000	1.000
544	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(1), ACAT2(6), ACYP1(1), ACYP2(1), ECHS1(2), EHHADH(14), GCDH(2), HADHA(3), SDHB(3), SDS(4)	2341548	37	25	37	17	7	6	7	11	6	0	0.813	1.000	1.000
545	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDFT1(1), FDPS(3), HMGCR(5), IDI1(2), LSS(3), MVD(2), MVK(1), NQO1(2), NQO2(1), PMVK(3), SQLE(3), VKORC1(1)	3334343	28	25	27	16	2	3	5	12	5	1	0.989	1.000	1.000
546	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(5), CAPN1(3), CAPNS1(1), CDK5(1), CDK5R1(1), CSNK1A1(1), GSK3B(6), MAPT(12), PPP2CA(4)	2939633	34	25	34	12	12	8	2	6	6	0	0.600	1.000	1.000
547	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(16), GNA12(1), PRKACB(3), PRKACG(1), PRKAR2A(3), PRKAR2B(1)	3028686	25	24	24	14	6	10	0	5	3	1	0.933	1.000	1.000
548	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(3), CYP11A1(2), CYP11B1(4), CYP11B2(9), CYP17A1(2), CYP21A2(1), HSD11B1(2), HSD3B1(1)	2733353	27	24	26	12	6	9	3	9	0	0	0.827	1.000	1.000
549	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(3), CYP11A1(2), CYP11B1(4), CYP11B2(9), CYP17A1(2), CYP21A2(1), HSD11B1(2), HSD3B1(1)	2733353	27	24	26	12	6	9	3	9	0	0	0.827	1.000	1.000
550	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(3), B3GALNT1(3), FUT1(2), FUT2(1), FUT9(2), GBGT1(4), GLA(1), HEXA(2), HEXB(1), NAGA(2), ST3GAL1(1), ST8SIA1(4)	3143187	26	24	26	11	4	6	1	12	3	0	0.875	1.000	1.000
551	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(3), ECHS1(2), EHHADH(14), HADH(1), HADHA(3), HSD17B4(8), SIRT1(5), SIRT2(3), SIRT5(2), VNN2(2)	3573672	43	24	43	16	11	9	9	12	2	0	0.415	1.000	1.000
552	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(2), ACTR2(2), ACTR3(3), ARPC1A(2), ARPC1B(2), ARPC2(5), ARPC4(2), CDC42(2), RAC1(1), WASF1(2), WASL(2)	2471819	25	24	25	12	6	7	3	4	5	0	0.805	1.000	1.000
553	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(4), BFAR(1), BRAF(2), CAMP(1), CREB1(1), CREB3(2), CREB5(5), MAPK1(3), RAF1(2), SNX13(5), SRC(2), TERF2IP(1)	3469233	29	24	29	12	3	9	4	10	3	0	0.782	1.000	1.000
554	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(5), IARS(9), LARS(5), LARS2(2), PDHA1(1), PDHA2(4), PDHB(2)	3004322	28	24	28	12	12	6	4	5	1	0	0.501	1.000	1.000
555	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), FOS(2), JUN(1), MAPK3(1), OPRK1(2), POLR2A(10), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1)	3792377	26	23	26	10	7	3	2	9	4	1	0.827	1.000	1.000
556	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(3), FUT1(2), FUT2(1), FUT9(2), GBGT1(4), GLA(1), HEXA(2), HEXB(1), NAGA(2), ST3GAL1(1), ST3GAL4(1), ST8SIA1(4)	2965234	24	23	24	12	3	7	0	11	3	0	0.954	1.000	1.000
557	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(1), ACAT2(6), BDH1(1), BDH2(3), HMGCL(1), HMGCS1(4), HMGCS2(3), OXCT1(7)	2282873	26	23	25	13	7	6	3	6	4	0	0.810	1.000	1.000
558	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT2(2), B3GNT7(1), B4GALT2(2), B4GALT3(2), B4GALT4(1), CHST1(2), CHST2(4), CHST4(1), CHST6(2), FUT8(2), ST3GAL1(1), ST3GAL3(4), ST3GAL4(1)	3517559	25	23	25	13	10	3	3	6	3	0	0.903	1.000	1.000
559	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(3), ACO2(4), AFMID(3), CS(1), HAO1(1), HAO2(1), HYI(1), MDH1(1), MDH2(2), MTHFD1(8), MTHFD1L(5), MTHFD2(1)	4006121	31	23	31	14	5	6	4	12	4	0	0.846	1.000	1.000
560	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(1), CDK5R1(1), FYN(2), LRP8(5), RELN(12), VLDLR(3)	4182288	24	23	24	23	6	4	3	7	4	0	1.000	1.000	1.000
561	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(3), CNR2(1), DNMT1(4), MTNR1A(5), PTGDR(1), PTGER2(5), PTGER4(1), PTGFR(3), PTGIR(2)	3296599	25	23	25	12	6	5	5	6	3	0	0.789	1.000	1.000
562	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	IFNG(3), IL2(1), IL2RA(2), IL4(1), TGFB1(1), TGFB2(4), TGFB3(3), TGFBR1(5), TGFBR2(1), TGFBR3(2), TOB1(2), TOB2(1)	3235656	26	23	26	10	4	6	6	6	4	0	0.717	1.000	1.000
563	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(2), ARFGAP3(3), ARFGEF2(2), CLTB(1), COPA(5), GBF1(6), GPLD1(4), KDELR1(1), KDELR3(2)	4849749	26	22	26	14	6	6	4	7	3	0	0.934	1.000	1.000
564	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CAMK1G(3), CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(1), CAMKK1(3), CAMKK2(3), CREB1(1), SYT1(1)	3564330	26	22	26	18	7	8	1	4	6	0	0.996	1.000	1.000
565	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(1), IL4(1), JUNB(2), MAPK14(4), NFATC1(3), NFATC2(4), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1)	3566928	24	22	24	10	4	6	2	6	5	1	0.919	1.000	1.000
566	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(4), CCNH(3), CDC25A(2), CDC25B(4), CDC25C(1), CDK7(1), MNAT1(1), SHH(2), XPO1(7)	2591372	25	22	25	11	8	8	1	6	2	0	0.747	1.000	1.000
567	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(10), BAX(1), BCL10(1), BCL2(1), BCL2L11(1), BID(2), CASP8AP2(6), CASP9(1), CES1(3)	3494932	26	22	26	15	4	7	4	5	6	0	0.919	1.000	1.000
568	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(5), CKM(2), EIF4E(2), FBL(2), GPT(5), LDHA(1), LDHB(2), LDHC(2), MAPK14(4), NCL(7)	2731176	32	22	30	16	7	7	2	12	4	0	0.931	1.000	1.000
569	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(5), BIRC3(6), CASP8(3), FADD(2), RIPK1(6), TNF(2), TNFRSF1A(2), TNFRSF1B(3)	2468784	29	22	29	10	7	7	2	10	3	0	0.627	1.000	1.000
570	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(7), FHL5(3), FSHR(2), GNAS(9), XPO1(7)	2869972	28	21	26	14	7	4	2	12	3	0	0.974	1.000	1.000
571	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(3), ACO2(4), CS(1), HAO1(1), HAO2(1), HYI(1), MDH1(1), MDH2(2), MTHFD1(8), MTHFD1L(5), MTHFD2(1)	3819808	28	21	28	11	5	4	4	11	4	0	0.743	1.000	1.000
572	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(2), ALAS1(2), ALAS2(3), CPOX(3), FECH(2), HMBS(3), PPOX(3), UROS(3)	2342631	21	21	21	10	6	1	1	6	7	0	0.928	1.000	1.000
573	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD4(3), FYN(2), HLA-DRB1(4), LCK(5), PTPRC(9), ZAP70(3)	2729378	26	21	25	24	3	4	6	10	3	0	1.000	1.000	1.000
574	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(2), AASDH(8), AASDHPPT(2), AASS(8), KARS(1)	2072184	21	20	21	11	4	9	0	5	3	0	0.827	1.000	1.000
575	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1G(3), HDAC9(6), MEF2A(4), MEF2C(3), MEF2D(1), MYOD1(3), YWHAH(1)	2578149	21	20	21	10	4	2	3	9	3	0	0.874	1.000	1.000
576	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(2), FOSL1(1), FOSL2(1), IFNAR1(5), IFNAR2(1), IFNB1(1), NFKB1(7), RELA(4), TNFRSF11A(1), TNFSF11(1), TRAF6(1)	3234644	25	20	25	16	4	3	3	9	6	0	0.988	1.000	1.000
577	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(1), CDK5R1(1), KLK2(3), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), NGFR(1), RAF1(2)	2495683	20	19	19	12	10	3	2	4	1	0	0.948	1.000	1.000
578	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(4), MMP2(1), MMP9(4), RECK(7), TIMP2(1), TIMP4(3)	2251730	20	19	20	14	4	6	2	6	2	0	0.993	1.000	1.000
579	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(2), MTMR2(3), MTMR6(5), NFS1(2), PHPT1(1), TPK1(4)	1908218	18	18	18	10	3	4	2	6	3	0	0.929	1.000	1.000
580	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(3), CS(1), MDH1(1), ME1(1), PC(10), PDHA1(1), SLC25A1(1), SLC25A11(1)	2726201	19	18	19	13	1	6	5	4	3	0	0.974	1.000	1.000
581	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(2), CYP11A1(2), CYP11B2(9), CYP17A1(2), HSD11B1(2), HSD3B1(1)	2078906	18	17	18	12	4	5	1	7	1	0	0.976	1.000	1.000
582	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH7A1(2), ALDH9A1(2), UGDH(4)	2544514	18	17	18	10	5	4	1	6	2	0	0.917	1.000	1.000
583	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), CHAT(5), CHKA(1), PCYT1A(4), PDHA1(1), PDHA2(4), PEMT(2)	2013787	19	16	19	11	5	6	2	5	1	0	0.934	1.000	1.000
584	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(3), ENO1(2), GPI(2), HK1(4), PFKL(3), PGAM1(1), PGK1(2), PKLR(1)	2753006	18	16	18	12	6	4	1	3	4	0	0.983	1.000	1.000
585	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(2), CYSLTR2(2), GPR161(4), GPR171(1), GPR18(3), GPR34(1), GPR39(1), GPR45(1), GPR65(1), GPR68(2)	2916084	18	16	18	13	4	6	0	7	1	0	0.992	1.000	1.000
586	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(5), APOBEC1(2), APOBEC2(1), APOBEC3B(2), APOBEC3F(3), APOBEC3G(1), APOBEC4(5)	2196118	19	16	17	11	2	3	4	6	4	0	0.966	1.000	1.000
587	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(2)	2377508	16	15	16	13	4	3	1	7	1	0	0.992	1.000	1.000
588	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(2)	2377508	16	15	16	13	4	3	1	7	1	0	0.992	1.000	1.000
589	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(4), CTH(3), GOT1(2), GOT2(2), LDHA(1), LDHB(2), LDHC(2)	1995922	16	15	16	12	7	5	0	4	0	0	0.973	1.000	1.000
590	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(4), GOT1(2), GOT2(2), TAT(1), TYR(6)	1399532	15	15	15	11	5	1	2	7	0	0	0.980	1.000	1.000
591	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(3), CD4(3), HLA-DRB1(4), IL1B(2), IL4(1), IL5RA(2), IL6(3)	1586882	19	15	18	16	1	4	5	8	1	0	0.995	1.000	1.000
592	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(1), ACAT2(6), HMGCL(1), OXCT1(7)	1022247	15	15	14	12	5	1	2	4	3	0	0.951	1.000	1.000
593	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(2), LPL(4), NR3C1(4), PPARG(1), RXRA(6), TNF(2)	1718923	19	15	19	8	4	6	2	7	0	0	0.787	1.000	1.000
594	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT2(2), B4GALT3(2), B4GALT5(2), FUT8(2), ST3GAL1(1), ST3GAL3(4), ST3GAL4(1)	2289634	14	14	14	10	3	3	2	4	2	0	0.980	1.000	1.000
595	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(1), IL1B(2), MST1(11), MST1R(4), TNF(2)	1916599	20	14	17	17	6	1	3	7	3	0	0.999	1.000	1.000
596	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(2), RANBP2(13), RANGAP1(2)	2412768	17	14	17	10	3	4	3	5	2	0	0.863	1.000	1.000
597	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(2), F13B(2), HSD17B2(1), HSD17B3(3), HSD17B4(8), HSD17B7(2), HSD3B1(1)	2422918	19	14	19	10	4	6	1	5	3	0	0.840	1.000	1.000
598	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(5), NDUFA5(2), NDUFA8(1), NDUFB5(1), NDUFB7(1), NDUFS1(3), NDUFS2(1), NDUFV2(2)	2122068	17	14	17	10	4	4	5	4	0	0	0.890	1.000	1.000
599	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(6), ADH6(2), ADH7(3), ADHFE1(1)	1679794	14	13	14	19	2	3	1	1	7	0	1.000	1.000	1.000
600	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(1), HS3ST2(1), HS3ST3A1(3), XYLT1(7), XYLT2(3)	1981013	16	13	16	16	4	4	0	5	3	0	1.000	1.000	1.000
601	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(1), HS3ST2(1), HS3ST3A1(3), XYLT1(7), XYLT2(3)	1981013	16	13	16	16	4	4	0	5	3	0	1.000	1.000	1.000
602	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(4), SRP54(4), SRP72(6), SRPR(2)	2250077	16	13	16	10	4	3	0	4	5	0	0.985	1.000	1.000
603	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(2), FARSA(1), FARSB(1), GOT1(2), GOT2(2), PAH(1), TAT(1), YARS2(3)	2592053	13	11	13	20	3	6	1	2	1	0	1.000	1.000	1.000
604	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(2), ENO2(1), ENO3(1), FARS2(2), GOT1(2), GOT2(2), PAH(1), TAT(1)	2445838	12	11	12	16	4	5	1	1	1	0	1.000	1.000	1.000
605	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(2), BMPR1A(1), BMPR1B(2), BMPR2(8)	1850637	13	11	13	11	2	3	2	1	5	0	0.988	1.000	1.000
606	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(1), PARK2(1), SNCA(2), SNCAIP(2), UBE2G1(1), UBE2G2(1), UBE2L3(1), UBE2L6(1)	1852128	10	10	10	8	3	4	1	2	0	0	0.938	1.000	1.000
607	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCR3(3), CSF2(2), HLA-DRB1(4), IL3(2)	877576	12	9	11	9	2	2	5	3	0	0	0.943	1.000	1.000
608	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(3), CD80(1), HLA-DRB1(4), IL2(1), IL4(1)	1186842	10	8	9	14	0	3	3	4	0	0	1.000	1.000	1.000
609	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A2(4), BCMO1(5)	1128850	9	8	9	8	2	3	0	4	0	0	0.986	1.000	1.000
610	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(3), HLA-DRB1(4)	705454	7	5	6	12	0	2	3	2	0	0	1.000	1.000	1.000
611	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), GOT2(2), TAT(1)	781511	5	5	5	8	2	1	1	1	0	0	0.998	1.000	1.000
612	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(1), HLCS(2), SPCS1(1), SPCS3(1)	929308	5	5	5	6	1	3	1	0	0	0	0.974	1.000	1.000
613	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(2), CD4(3)	971213	5	5	5	4	1	3	0	1	0	0	0.965	1.000	1.000
614	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C9(4)	605155	4	4	4	4	2	2	0	0	0	0	0.950	1.000	1.000
615	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	SLPI(1)	488436	1	1	1	3	0	1	0	0	0	0	0.993	1.000	1.000
616	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3		347171	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000