rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(1), FOSB(1), GRIA2(10), JUND(2), PPP1R1B(2) 1119909 16 15 16 1 5 4 2 3 2 0 0.0446 0.00998 1.000 2 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(7) 210646 7 7 7 2 1 2 1 3 0 0 0.616 0.0204 1.000 3 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(8), LPO(8), MPO(11), PRDX1(1), PRDX2(2), PRDX5(3), PRDX6(1), TPO(11), TYR(6) 2928607 51 43 51 9 11 8 9 15 8 0 0.0310 0.186 1.000 4 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(2) 151093 2 2 2 1 0 0 0 1 1 0 0.941 0.358 1.000 5 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 12 CREB1(1), FOS(2), JUN(1), KEAP1(9), MAFG(1), MAPK1(3), MAPK14(4), PRKCA(2) 2376267 23 21 23 2 5 5 4 6 3 0 0.0440 0.395 1.000 6 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(6) 501887 6 5 6 0 1 1 2 1 1 0 0.117 0.453 1.000 7 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(2), BCKDK(3), CBS(5), CTH(3), MUT(4) 1474395 17 14 17 2 3 4 0 3 7 0 0.202 0.486 1.000 8 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(4), GLS2(3), GLUD1(3), GLUD2(3) 1320815 13 13 13 2 1 6 3 1 2 0 0.212 0.565 1.000 9 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(3), PGLYRP2(1) 518233 4 4 4 1 0 2 0 1 1 0 0.753 0.610 1.000 10 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(8), GBA(1), LPO(8), MPO(11), PRDX6(1), TPO(11) 2527768 40 34 40 9 10 7 8 10 5 0 0.110 0.641 1.000 11 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(3), ECHS1(2), EHHADH(14), HADHA(3), SDS(4) 1469142 26 17 26 7 5 4 5 9 3 0 0.292 0.759 1.000 12 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(1), TGDS(1), UGDH(4) 1212264 6 6 6 1 2 2 0 0 2 0 0.453 0.902 1.000 13 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(4), AOC2(3), AOC3(3), CES1(3), ESD(2) 1815413 15 15 15 3 1 4 4 5 1 0 0.206 0.903 1.000 14 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(2), PSMA2(1), PSMA4(3), PSMA5(1), PSMA6(1), PSMA7(4), PSMB1(2), PSMB10(2), PSMB2(1), PSMB3(1), PSMB5(3), PSMB6(1), PSMB7(2), PSMB8(4), PSMB9(1) 2625712 29 23 29 6 3 5 6 11 4 0 0.220 0.926 1.000 15 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(1), IFNG(3), IL12A(6), IL12B(2), IL16(7), IL18(2), IL1A(3), IL2(1), IL3(2), IL4(1), IL6(3), IL9(1), LTA(2), TNF(2) 2973045 36 29 36 9 5 3 8 15 5 0 0.233 0.938 1.000 16 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(1) 451428 1 1 1 0 0 0 0 1 0 0 0.849 0.945 1.000 17 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(4), CS(1), FH(4), IDH2(5), MDH1(1), OGDH(4), SDHA(5), SUCLA2(3) 2847561 27 22 27 4 4 2 6 13 2 0 0.0966 0.966 1.000 18 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(10), EGFR(7), ERBB3(10), NRG1(7), UBE2D1(1) 3037157 35 33 35 9 3 12 3 10 7 0 0.292 0.974 1.000 19 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(4), IFNG(3), IL12A(6), IL12B(2), IL18(2), IL2(1) 925112 18 15 18 8 1 1 3 10 3 0 0.860 0.975 1.000 20 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(1), EPHX2(2), HSD3B7(2), RDH11(2), RDH12(2), RDH13(1) 1379127 10 10 10 3 4 0 1 4 1 0 0.615 0.976 1.000 21 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(2), PLCD1(1), PRKCA(2), TGM2(5) 1536505 10 9 10 2 7 2 0 1 0 0 0.415 0.977 1.000 22 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(1), TGDS(1), UGDH(4), UGP2(2) 1522119 8 8 8 2 2 2 0 1 3 0 0.603 0.980 1.000 23 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(1), CASP3(2), CASP8(3), CFL1(3), CFLAR(2) 1141167 11 11 11 7 5 1 0 2 3 0 0.960 0.981 1.000 24 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), CSF2(2), FLT3(10), IGF1(1), IL1A(3), IL3(2), IL6(3), IL9(1), KITLG(2), TGFB1(1), TGFB2(4), TGFB3(3) 2591230 33 29 33 8 6 9 9 5 4 0 0.153 0.988 1.000 25 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), NRF1(1), UBE2B(2), UBE2C(1), UBE2D1(1), UBE2D2(2), UBE2D3(2), UBE2E1(3), UBE2G1(1), UBE2G2(1), UBE2H(1), UBE2J1(4), UBE2J2(3), UBE2L3(1), UBE2L6(1), UBE2M(2), UBE2N(4), UBE2S(1), UBE3A(4) 3128959 36 32 36 8 8 7 5 8 8 0 0.181 0.989 1.000 26 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(2), RAB11A(1), RAB1A(3), RAB27A(2), RAB4A(2), RAB6A(2), RAB9A(1) 1291001 13 11 13 4 3 3 1 3 3 0 0.631 0.989 1.000 27 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(2), ESR1(4), GREB1(14), HSPB2(4), MTA1(2), PDZK1(2), TUBA8(4) 3407013 32 31 32 7 11 8 2 8 3 0 0.144 0.993 1.000 28 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(1), FUT1(2), FUT2(1), FUT3(3), FUT5(4), FUT6(3), ST3GAL3(4) 1514085 18 10 16 4 8 2 2 4 2 0 0.338 0.994 1.000 29 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(9), GNB1(4), GNGT1(1), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(2) 2942258 27 25 25 6 8 6 1 7 4 1 0.414 0.994 1.000 30 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(2), CDC25B(4), CDK7(1), CDKN1A(6), CHEK1(7), NEK1(9), WEE1(4) 2287862 33 27 33 8 3 9 2 13 6 0 0.356 0.994 1.000 31 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), ATP6V0C(1), CAT(1), EPX(8), LPO(8), MPO(11), PRDX1(1), PRDX2(2), PRDX5(3), PRDX6(1), SHMT1(4), SHMT2(2), TPO(11) 3550798 54 42 54 13 13 9 8 12 12 0 0.168 0.995 1.000 32 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(6), ALDOB(3) 1174597 9 8 9 4 1 2 2 2 2 0 0.772 0.996 1.000 33 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), PTK2B(8), SHC1(5), SOS1(10), SRC(2) 2590480 26 23 26 6 5 6 3 5 6 1 0.351 0.996 1.000 34 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(1), FDPS(3), IDI1(2), SQLE(3) 1000310 9 9 9 5 2 0 2 3 2 0 0.859 0.996 1.000 35 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(1), SUCLA2(3) 642498 4 4 4 7 1 0 0 2 1 0 1.000 0.997 1.000 36 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), GSTZ1(2), HGD(2) 660988 5 5 5 3 2 0 0 2 1 0 0.917 0.997 1.000 37 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 9 BPNT1(2), PAPSS1(4), PAPSS2(5), SULT1A2(4), SULT1E1(1), SULT2A1(3), SUOX(4) 2548761 23 20 22 5 5 6 3 7 2 0 0.305 0.998 1.000 38 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(3), NDUFA1(1), SDHA(5), SDHB(3) 1956422 12 11 12 3 2 1 3 5 1 0 0.513 0.998 1.000 39 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(4), DCN(2), FMOD(2), KERA(2), LUM(2) 1073872 12 11 12 5 4 3 1 2 2 0 0.835 0.998 1.000 40 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(7), GNAS(9), GNB1(4), GNGT1(1), PRKACA(2) 1975095 23 21 21 5 6 4 2 9 2 0 0.412 0.998 1.000 41 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(3), COQ5(2), COQ6(4), COQ7(1), NDUFB11(1) 1281917 11 8 10 6 2 2 1 4 2 0 0.907 0.998 1.000 42 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(2), CDKN1A(6), GRIN1(6), HIF1A(3), JAK2(9), NFKB1(7), NFKBIA(2), RELA(4) 3909470 39 34 39 9 4 11 4 13 7 0 0.347 0.998 1.000 43 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNB1(4), GNGT1(1), HTR2C(7), PLCB1(11), TUB(3) 2136478 26 22 25 8 3 5 1 9 8 0 0.704 0.998 1.000 44 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(2), PLCG1(10), PRKCA(2), PTK2B(8) 1992597 22 20 22 6 5 6 0 3 8 0 0.755 0.998 1.000 45 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(2), ACTR3(3), ARPC1A(2), ARPC1B(2), ARPC2(5), ARPC4(2), CDC42(2), PAK1(4), PDGFRA(10), PIK3CA(10), PIK3R1(5), RAC1(1), WASL(2) 4055665 50 41 49 11 12 11 9 11 7 0 0.0777 0.998 1.000 46 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 5 NFYA(4), NFYC(2), SP1(2), SP3(3) 1476527 11 11 11 8 2 2 1 3 3 0 0.976 0.999 1.000 47 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), SHMT1(4), SHMT2(2) 1302428 7 7 7 3 3 1 0 1 2 0 0.772 0.999 1.000 48 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(1), FDPS(3), GGPS1(2), IDI1(2), IDI2(1), SQLE(3) 1319956 12 12 12 6 2 1 3 3 3 0 0.822 0.999 1.000 49 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(3), ASL(2), CPS1(10), GLS(4), GLUD1(3), GOT1(2) 2315557 24 22 24 8 8 10 0 3 3 0 0.491 0.999 1.000 50 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 15 AKT1(2), BCAR1(3), CDKN1B(2), ILK(1), ITGB1(3), MAPK1(3), MAPK3(1), PDK2(2), PDPK1(2), PIK3CA(10), PIK3R1(5), PTK2(9), SHC1(5), SOS1(10) 5671361 58 44 57 10 13 14 8 15 7 1 0.0247 0.999 1.000 51 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(6), ACADM(1), ACADS(3), ACAT1(1), ECHS1(2), HADHA(3) 1633180 16 13 16 7 3 4 2 4 3 0 0.695 1.000 1.000 52 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(2), GAD1(5), HDC(5), TH(3), TPH1(3) 1779569 18 17 18 6 6 2 1 4 5 0 0.735 1.000 1.000 53 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 14 ARF1(2), ARF3(1), CCND1(1), CDKN1A(6), CDKN1B(2), CDKN2A(3), CFL1(3), E2F1(2), MDM2(2), PRB1(2) 2195657 24 20 24 8 6 1 0 11 6 0 0.773 1.000 1.000 54 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(2), ALAS1(2), ALAS2(3), CPO(4), FECH(2), GATA1(3), HMBS(3), UROS(3) 2558587 22 21 21 7 5 2 1 6 8 0 0.692 1.000 1.000 55 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(3), FOS(2), IL3(2), JAK2(9), MAP2K1(5), MAPK3(1), PTPN6(2), RAF1(2), SHC1(5), SOS1(10), STAT5A(2), STAT5B(3) 5409015 46 39 46 9 10 12 8 10 5 1 0.0850 1.000 1.000 56 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(5), NR0B2(3), NR1H3(3), NR1H4(3), RXRA(6) 1593196 20 18 20 6 1 5 4 7 2 1 0.597 1.000 1.000 57 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(4), ARG1(3), GLS(4), GLUD1(3), OAT(3), PRODH(3) 1747356 20 16 20 6 2 7 2 6 3 0 0.576 1.000 1.000 58 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(1), FUT1(2), FUT2(1), FUT9(2), GCNT2(7), ST8SIA1(4) 1837896 17 16 17 5 2 5 1 6 3 0 0.594 1.000 1.000 59 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRNA1(3), SNAP25(2), STX1A(1) 933076 6 6 6 3 0 3 0 2 1 0 0.946 1.000 1.000 60 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(2), AASDHPPT(2), AASS(8), KARS(1) 1410194 13 12 13 5 3 7 0 1 2 0 0.597 1.000 1.000 61 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(1), ALPL(3), ALPP(6), ALPPL2(3), FPGS(4), GGH(1) 2063515 18 17 17 7 1 5 1 8 3 0 0.894 1.000 1.000 62 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(10), PDXK(1), PSAT1(3) 1431980 14 12 14 5 0 9 1 3 1 0 0.668 1.000 1.000 63 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(2), ECHS1(2), HADH(1), HADHA(3), HADHB(2), HSD17B4(8), MECR(3), PPT1(1), PPT2(2) 2587513 24 20 24 8 6 7 4 5 2 0 0.341 1.000 1.000 64 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(1), CSF1(1), IL6(3), LDLR(5), LPL(4) 1580487 14 12 14 8 3 2 3 4 2 0 0.903 1.000 1.000 65 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP2E1(2), PTGS1(3), PTGS2(2) 1574856 7 7 7 8 1 1 1 3 1 0 0.998 1.000 1.000 66 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 AKT1(2), CAT(1), GH1(2), GHR(8), IGF1(1), IGF1R(12), PIK3CA(10), PIK3R1(5), SHC1(5) 3916943 46 36 45 11 11 10 8 12 5 0 0.147 1.000 1.000 67 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(2), CXCR3(1), ETV5(2), IFNG(3), IL12A(6), IL12B(2), IL12RB1(5), IL12RB2(10), IL18(2), IL18R1(3), JAK2(9), JUN(1), MAP2K6(1), MAPK14(4), STAT4(7), TYK2(7) 5661333 65 51 65 15 11 18 8 17 11 0 0.123 1.000 1.000 68 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(4), LDLR(5), MBTPS1(6), MBTPS2(1), SCAP(4), SREBF1(4), SREBF2(7) 3704930 31 29 31 9 8 7 3 7 6 0 0.357 1.000 1.000 69 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(2), GSR(3), GSS(4), NFKB1(7), NOX1(5), RELA(4), TNF(2), XDH(13) 3042787 40 35 40 10 5 12 7 12 4 0 0.281 1.000 1.000 70 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(1), EPX(8), LPO(8), MPO(11), MTHFR(4), PRDX6(1), SHMT1(4), SHMT2(2), TPO(11) 3459428 51 42 51 13 16 7 9 11 8 0 0.179 1.000 1.000 71 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(3), CD8A(1), CSF1(1), CSF2(2), IL2(1), IL3(2), IL4(1), IL6(3), IL7(2), IL9(1) 1887596 17 15 17 8 2 4 5 4 2 0 0.812 1.000 1.000 72 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(4), CAMP(1), ITPKA(1), ITPKB(2) 1773502 8 7 8 9 3 2 2 0 1 0 0.994 1.000 1.000 73 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(2), GBA(1), SHMT1(4), SHMT2(2) 1740209 9 9 9 5 3 2 1 2 1 0 0.842 1.000 1.000 74 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(2), PSMA2(1), PSMA4(3), PSMA5(1), PSMA6(1), PSMA7(4), PSMB1(2), PSMB2(1), PSMB3(1), PSMB5(3), PSMB6(1), PSMB7(2), PSMC2(2), PSMD1(9), PSMD11(2), PSMD12(4), PSMD13(3), PSMD2(5), PSMD6(2) 4826391 49 35 49 12 7 8 6 22 6 0 0.309 1.000 1.000 75 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(1), B3GALT1(1), B3GALT2(1), FUT1(2), FUT2(1), FUT3(3), ST3GAL3(4), ST3GAL4(1) 2143518 14 10 14 6 4 3 0 5 2 0 0.834 1.000 1.000 76 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 8 CCNA1(2), CCNE1(2), CDC34(1), CUL1(3), E2F1(2), SKP2(3), TFDP1(3) 2077911 16 14 16 9 4 4 1 2 5 0 0.974 1.000 1.000 77 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 MYC(2), SP1(2), SP3(3), WT1(6) 1860148 13 13 13 5 4 4 1 3 1 0 0.623 1.000 1.000 78 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 20 AKT1(2), EIF4A1(1), EIF4A2(2), EIF4B(3), EIF4E(2), EIF4EBP1(1), EIF4G1(10), EIF4G2(6), EIF4G3(10), MKNK1(2), PDK2(2), PDPK1(2), PIK3CA(10), PIK3R1(5), PPP2CA(4), RPS6(1), RPS6KB1(5), TSC1(13), TSC2(15) 8244140 96 67 94 20 18 26 13 15 23 1 0.0281 1.000 1.000 79 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(2), CD4(3), CD58(2), CD8A(1), IL3(2), IL6(3), KITLG(2) 1877994 15 12 15 7 2 4 5 3 1 0 0.732 1.000 1.000 80 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(2), CDO1(1), CSAD(3), GAD1(5), GAD2(2) 1769236 13 13 13 8 1 4 1 5 2 0 0.970 1.000 1.000 81 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(1), DHRS3(1), DHRS7(2), DHRSX(5), ESCO1(4), ESCO2(5), NAT6(2), PNPLA3(3), SH3GLB1(2) 4858622 25 21 23 6 9 5 2 7 2 0 0.166 1.000 1.000 82 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(3), ST3GAL1(1), ST3GAL4(1), ST3GAL5(2), ST6GALNAC2(3), ST6GALNAC4(1), ST8SIA1(4) 1657593 15 15 15 8 4 5 1 4 1 0 0.927 1.000 1.000 83 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(3), ADORA2A(2), ADORA2B(4), ADORA3(3), LTB4R(1), P2RY1(5), P2RY2(2), P2RY6(1) 1677515 21 18 21 8 1 4 1 14 1 0 0.830 1.000 1.000 84 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(2), CCNA2(2), CCND1(1), CCNE1(2), CCNE2(3), CDKN1B(2), CDKN2A(3), E2F1(2), E2F4(2), PRB1(2) 2659998 21 19 21 9 6 3 2 7 3 0 0.759 1.000 1.000 85 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(2), CD2(2), CD4(3), CXCR3(1), IFNG(3), IL12A(6), IL12B(2), IL12RB1(5), IL12RB2(10), JAK2(9), STAT4(7), TYK2(7) 4510643 57 46 57 15 9 19 4 18 7 0 0.265 1.000 1.000 86 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(2), CHRNB1(4), CHRNG(1), MUSK(9), PIK3CA(10), PIK3R1(5), PTK2(9), PTK2B(8), RAPSN(3), SRC(2), TERT(3), YWHAH(1) 4992702 57 43 56 14 10 17 6 14 10 0 0.232 1.000 1.000 87 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(3), CFL1(3), GNAS(9), GNB1(4), GNGT1(1), LIMK1(2), MAP2K1(5), MAPK1(3), MAPK3(1), NOX1(5), PIK3C2G(11), PLCB1(11), PPP1R12B(5), PRKCA(2), PTK2(9), RAF1(2), ROCK2(8) 7709843 85 64 83 19 18 24 10 21 12 0 0.105 1.000 1.000 88 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(8), AGT(2), AGTR1(3), BDKRB2(4), KNG1(5), NOS3(8), REN(1) 3005927 31 25 30 9 7 6 1 14 3 0 0.605 1.000 1.000 89 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(9), DLL1(2), FURIN(3), NOTCH1(6), PSEN1(2) 2833550 22 20 22 8 8 5 3 4 2 0 0.534 1.000 1.000 90 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(2), CD36(1), FOS(2), FYN(2), JUN(1), MAPK14(4), THBS1(3) 2120615 15 15 15 6 2 1 4 6 2 0 0.801 1.000 1.000 91 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(1), DHRS1(1), DHRS3(1), DHRS7(2), DHRSX(5), HSD3B7(2), PON1(2), PON3(1), RDH11(2), RDH12(2), RDH13(1) 2646994 20 17 18 7 10 2 1 6 1 0 0.614 1.000 1.000 92 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(2), APAF1(10), BCL2(1), CASP3(2), CASP9(1), DAXX(1), FAS(5), FASLG(2), HSPB2(4), IL1A(3), MAPKAPK2(4), MAPKAPK3(1), TNF(2) 3317290 38 35 36 11 7 10 4 11 6 0 0.383 1.000 1.000 93 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(3), CLOCK(4), CRY1(5), CSNK1E(3), PER1(4) 2525756 19 17 19 7 3 10 0 4 2 0 0.638 1.000 1.000 94 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(6), ACOX3(7), FADS2(1), PLA2G12A(2), PLA2G12B(2), PLA2G1B(1), PLA2G2A(1), PLA2G2D(3), PLA2G2E(1), PLA2G2F(6), PLA2G3(4), PLA2G4A(6), PLA2G6(6) 3235681 46 35 45 12 11 7 10 16 2 0 0.200 1.000 1.000 95 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(5), ACP2(1), ACP5(2), ACPP(5), ACPT(1), ENPP1(4), ENPP3(8), FLAD1(4), RFK(1), TYR(6) 2934608 37 24 37 11 5 7 7 15 3 0 0.447 1.000 1.000 96 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(4), CDC25A(2), CDC25B(4), CDC25C(1), CSK(2), PRKCA(2), PTPRA(5), SRC(2) 2772023 22 20 21 7 5 6 2 6 3 0 0.560 1.000 1.000 97 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(2), KLK2(3), NTRK1(5), PIK3CA(10), PIK3R1(5), PLCG1(10), PRKCA(2), SHC1(5), SOS1(10) 4700698 52 41 50 14 15 14 7 10 5 1 0.258 1.000 1.000 98 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(5), IL13RA2(5), IL4R(4), JAK1(8), JAK2(9), TYK2(7) 3124714 38 32 38 10 8 13 1 8 8 0 0.488 1.000 1.000 99 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(5), IL13RA2(5), IL4R(4), JAK1(8), JAK2(9), TYK2(7) 3124714 38 32 38 10 8 13 1 8 8 0 0.488 1.000 1.000 100 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(2), IGF1R(12), IRS1(4), MAP2K1(5), MAPK1(3), MAPK3(1), PIK3CA(10), PIK3R1(5), RAF1(2), SHC1(5), SOS1(10), YWHAH(1) 5615958 60 47 59 16 15 13 9 16 6 1 0.229 1.000 1.000 101 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 21 AKT1(2), EIF4A1(1), EIF4A2(2), EIF4E(2), EIF4EBP1(1), EIF4G1(10), EIF4G2(6), EIF4G3(10), GHR(8), IRS1(4), MAPK1(3), MAPK14(4), MAPK3(1), MKNK1(2), PABPC1(9), PDK2(2), PDPK1(2), PIK3CA(10), PIK3R1(5), PRKCA(2), RPS6KB1(5) 8315931 91 63 87 22 21 26 16 13 14 1 0.0545 1.000 1.000 102 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(2), FOS(2), JAK2(9), JUN(1), MAP2K1(5), MAPK3(1), PLCG1(10), PTPN6(2), RAF1(2), SHC1(5), SOS1(10), STAT5A(2), STAT5B(3) 6602849 54 44 54 12 13 17 6 8 9 1 0.189 1.000 1.000 103 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(3), ACO2(4), FH(4), IDH1(7), IDH2(5), MDH1(1), MDH2(2), SDHB(3), SUCLA2(3) 2686497 32 25 30 10 5 4 8 12 3 0 0.487 1.000 1.000 104 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(2), FOS(2), IGF1(1), IGF1R(12), IRS1(4), JUN(1), MAP2K1(5), MAPK3(1), PIK3CA(10), PIK3R1(5), PTPN11(2), RAF1(2), RASA1(10), SHC1(5), SOS1(10), SRF(1) 7408440 73 54 72 19 14 17 12 18 11 1 0.200 1.000 1.000 105 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(2), GHR(8), INSR(11), IRS1(4), JAK2(9), MAP2K1(5), MAPK1(3), MAPK3(1), PIK3CA(10), PIK3R1(5), PLCG1(10), PRKCA(2), PTPN6(2), RAF1(2), RPS6KA1(4), SHC1(5), SLC2A4(1), SOS1(10), SRF(1), STAT5A(2), STAT5B(3) 9988717 100 67 99 20 29 25 11 20 14 1 0.0193 1.000 1.000 106 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(10), BAX(1), BCL2(1), BID(2), BIK(3), BIRC2(6), BIRC3(6), CASP3(2), CASP6(2), CASP7(4), CASP8(3), CASP9(1), DFFA(2), DFFB(3), DIABLO(3), ENDOG(2) 4038251 51 36 50 15 9 13 4 13 12 0 0.489 1.000 1.000 107 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(2), FOS(2), INSR(11), IRS1(4), JUN(1), MAP2K1(5), MAPK3(1), PIK3CA(10), PIK3R1(5), PTPN11(2), RAF1(2), RASA1(10), SHC1(5), SLC2A4(1), SOS1(10), SRF(1) 7624155 72 53 71 19 14 16 11 19 11 1 0.206 1.000 1.000 108 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(3), CXCL12(2), CXCR4(2), GNAI1(4), GNB1(4), GNGT1(1), MAP2K1(5), MAPK1(3), MAPK3(1), NFKB1(7), PIK3C2G(11), PIK3CA(10), PIK3R1(5), PLCG1(10), PRKCA(2), PTK2(9), PTK2B(8), PXN(5), RAF1(2), RELA(4) 8474607 98 73 97 25 19 28 11 21 19 0 0.220 1.000 1.000 109 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(2), FOS(2), JAK2(9), JUN(1), MAP2K1(5), MAPK3(1), MPL(1), PIK3CA(10), PIK3R1(5), PLCG1(10), PRKCA(2), RAF1(2), RASA1(10), SHC1(5), SOS1(10), STAT1(7), STAT3(5), STAT5A(2), STAT5B(3), THPO(1) 9046162 93 66 92 22 17 30 11 19 15 1 0.134 1.000 1.000 110 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(5), COASY(3), DPYD(17), ENPP1(4), ENPP3(8), PANK1(1), PANK2(2), PANK3(2), PANK4(2), PPCS(2), UPB1(1) 4159239 47 35 45 14 12 12 8 12 3 0 0.237 1.000 1.000 111 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(2), PIK3CA(10), PIK3R1(5), PLCB1(11), PLCG1(10), PRKCA(2), VAV1(6) 3881926 46 37 45 13 10 12 3 13 8 0 0.498 1.000 1.000 112 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(2), F2R(2), F2RL3(1), GNAI1(4), GNB1(4), GNGT1(1), ITGA1(7), ITGB1(3), MAP2K1(5), MAPK1(3), MAPK3(1), PLA2G4A(6), PLCB1(11), PRKCA(2), PTGS1(3), PTK2(9), RAF1(2), SRC(2), SYK(4), TBXAS1(2) 7293868 74 61 74 20 11 22 8 24 9 0 0.300 1.000 1.000 113 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(7), AKT1(2), CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), CREB1(1), GNAS(9), MAPK1(3), MAPK14(4), MAPK3(1), PIK3CA(10), PIK3R1(5), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(2), RAC1(1), RPS6KA1(4), RPS6KA5(3), SOS1(10) 8845639 84 59 81 22 23 17 8 23 11 2 0.251 1.000 1.000 114 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(2), FOS(2), JUN(1), KLK2(3), MAP2K1(5), MAPK3(1), NGFR(1), PIK3CA(10), PIK3R1(5), PLCG1(10), RAF1(2), SHC1(5), SOS1(10) 5718655 57 45 55 17 14 14 9 12 7 1 0.344 1.000 1.000 115 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(4), PGAP1(1), PIGA(3), PIGB(3), PIGC(1), PIGF(3), PIGG(5), PIGH(2), PIGL(3), PIGM(6), PIGN(8), PIGO(4), PIGQ(5), PIGS(6), PIGU(2), PIGV(1), PIGW(4), PIGX(2), PIGZ(4) 7459856 67 41 67 19 18 9 4 23 13 0 0.389 1.000 1.000 116 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(7), ARHGEF1(3), F2(2), F2R(2), F2RL3(1), GNA12(1), GNA13(2), GNAI1(4), GNB1(4), GNGT1(1), MAP3K7(3), PIK3CA(10), PIK3R1(5), PLCB1(11), PPP1R12B(5), PRKCA(2), PTK2B(8), ROCK1(7) 7725934 78 54 77 21 11 19 8 23 17 0 0.398 1.000 1.000 117 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(7), ADCY2(10), ADCY3(7), ADCY4(6), ADCY7(3), ADCY8(12), ADCY9(9), ADORA2A(2), ADORA2B(4), ADRA1A(3), ADRA1B(2), ADRA1D(3), ADRB1(1), ADRB2(5), ADRB3(1), AGTR1(3), ATP2A1(4), ATP2A2(2), ATP2A3(3), ATP2B1(8), ATP2B2(6), ATP2B3(3), ATP2B4(4), AVPR1B(2), BDKRB1(2), BDKRB2(4), BST1(2), CACNA1A(7), CACNA1B(15), CACNA1C(8), CACNA1D(9), CACNA1E(28), CACNA1F(7), CACNA1G(7), CACNA1H(13), CACNA1I(6), CACNA1S(7), CALM1(1), CALML6(1), CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(1), CCKBR(4), CD38(2), CHRM2(5), CHRM3(4), CHRM5(3), CHRNA7(1), CYSLTR1(2), CYSLTR2(2), EDNRA(3), EDNRB(2), EGFR(7), ERBB2(4), ERBB3(10), ERBB4(9), F2R(2), GNA14(1), GNA15(2), GNAL(4), GNAS(9), GRIN1(6), GRIN2A(6), GRIN2C(4), GRIN2D(4), GRM1(8), GRM5(5), HRH1(1), HRH2(3), HTR2A(2), HTR2B(4), HTR2C(7), HTR4(1), HTR5A(1), HTR6(4), HTR7(10), ITPKA(1), ITPKB(2), ITPR1(18), ITPR2(19), ITPR3(15), LHCGR(7), MYLK(4), MYLK2(4), NOS1(15), NOS3(8), OXTR(2), P2RX1(2), P2RX2(2), P2RX3(3), P2RX4(1), P2RX5(2), P2RX7(3), PDE1A(2), PDE1B(3), PDE1C(11), PDGFRA(10), PDGFRB(2), PHKA1(10), PHKA2(5), PHKB(11), PHKG1(1), PHKG2(4), PLCB1(11), PLCB2(4), PLCB3(5), PLCB4(16), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(14), PLCG1(10), PLCG2(16), PLCZ1(2), PPID(2), PPP3CA(6), PPP3CB(5), PPP3CC(1), PPP3R1(1), PRKACA(2), PRKACB(3), PRKACG(1), PRKCA(2), PRKCG(2), PRKX(4), PTGER3(2), PTGFR(3), PTK2B(8), RYR1(26), RYR2(47), RYR3(32), SLC25A4(1), SLC25A5(3), SLC25A6(1), SLC8A1(9), SLC8A2(7), SLC8A3(2), SPHK1(6), SPHK2(4), TACR1(5), TACR2(6), TACR3(4), TNNC2(2), TRHR(5), TRPC1(6), VDAC1(1), VDAC2(1), VDAC3(1) 83762403 844 182 835 370 201 180 74 278 107 4 1.000 1.000 1.000 118 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 190 ACTB(1), ACTG1(1), ACTN1(5), ACTN2(8), ACTN3(1), ACTN4(2), AKT1(2), AKT2(7), AKT3(4), ARHGAP5(6), BCAR1(3), BCL2(1), BIRC2(6), BIRC3(6), BRAF(2), CAPN2(1), CAV1(1), CAV2(3), CCND1(1), CCND2(1), CDC42(2), COL11A1(18), COL11A2(8), COL1A1(3), COL1A2(7), COL2A1(5), COL3A1(7), COL4A1(7), COL4A2(10), COL4A4(11), COL4A6(11), COL5A1(11), COL5A2(11), COL5A3(5), COL6A1(7), COL6A2(6), COL6A3(20), COL6A6(27), COMP(2), DIAPH1(6), DOCK1(14), EGF(10), EGFR(7), ERBB2(4), FARP2(7), FIGF(1), FLNA(8), FLNB(10), FLNC(10), FLT1(11), FN1(14), FYN(2), GSK3B(6), HGF(9), IBSP(8), IGF1(1), IGF1R(12), ILK(1), ITGA1(7), ITGA10(10), ITGA11(10), ITGA2(7), ITGA2B(5), ITGA3(5), ITGA4(7), ITGA5(4), ITGA6(3), ITGA7(8), ITGA8(6), ITGA9(8), ITGAV(9), ITGB1(3), ITGB3(3), ITGB4(9), ITGB5(7), ITGB6(5), ITGB7(2), ITGB8(9), JUN(1), KDR(13), LAMA1(30), LAMA2(16), LAMA3(20), LAMA4(11), LAMA5(18), LAMB1(5), LAMB2(4), LAMB3(4), LAMB4(12), LAMC1(16), LAMC2(4), LAMC3(7), MAP2K1(5), MAPK1(3), MAPK10(4), MAPK3(1), MAPK9(4), MET(2), MYL5(1), MYL9(1), MYLK(4), MYLK2(4), MYLPF(1), PAK1(4), PAK2(8), PAK3(6), PAK4(3), PAK6(4), PAK7(9), PARVA(3), PARVB(3), PDGFA(2), PDGFB(1), PDGFC(5), PDGFD(2), PDGFRA(10), PDGFRB(2), PDPK1(2), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PIP5K1C(3), PPP1CA(3), PPP1CB(3), PPP1CC(1), PPP1R12A(8), PRKCA(2), PRKCG(2), PTK2(9), PXN(5), RAC1(1), RAC2(4), RAF1(2), RAP1A(2), RAPGEF1(7), RELN(12), ROCK1(7), ROCK2(8), SHC1(5), SHC2(1), SHC4(5), SOS1(10), SOS2(8), SPP1(1), SRC(2), THBS1(3), THBS2(5), THBS3(5), THBS4(3), TLN1(12), TLN2(11), TNC(11), TNN(12), TNR(11), TNXB(23), VASP(3), VAV1(6), VAV2(2), VAV3(7), VCL(4), VEGFB(2), VEGFC(5), VTN(2), VWF(10), ZYX(2) 112818063 1060 178 1050 491 219 258 119 305 149 10 1.000 1.000 1.000 119 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(3), ACVR1C(1), AKT1(2), AKT2(7), AKT3(4), ARRB1(2), ARRB2(2), ATF2(1), ATF4(6), BDNF(1), BRAF(2), CACNA1A(7), CACNA1B(15), CACNA1C(8), CACNA1D(9), CACNA1E(28), CACNA1F(7), CACNA1G(7), CACNA1H(13), CACNA1I(6), CACNA1S(7), CACNA2D1(11), CACNA2D2(6), CACNA2D3(4), CACNA2D4(8), CACNB1(3), CACNB2(2), CACNB4(7), CACNG1(2), CACNG2(4), CACNG3(2), CACNG4(3), CACNG5(1), CACNG7(1), CACNG8(2), CASP3(2), CDC25B(4), CDC42(2), CHUK(9), DAXX(1), DDIT3(1), DUSP1(1), DUSP14(1), DUSP16(3), DUSP2(1), DUSP6(3), DUSP7(1), DUSP8(1), DUSP9(2), ECSIT(3), EGF(10), EGFR(7), ELK4(2), FAS(5), FASLG(2), FGF10(2), FGF11(1), FGF13(2), FGF14(4), FGF20(3), FGF21(1), FGF3(3), FGF5(2), FGF6(3), FGF8(1), FGF9(1), FGFR1(2), FGFR2(8), FGFR3(6), FGFR4(1), FLNA(8), FLNB(10), FLNC(10), FOS(2), GADD45A(1), GNA12(1), GNG12(1), IKBKB(6), IL1A(3), IL1B(2), IL1R1(4), IL1R2(2), JUN(1), JUND(2), KRAS(4), MAP2K1(5), MAP2K2(3), MAP2K4(4), MAP2K5(1), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K10(1), MAP3K12(2), MAP3K13(3), MAP3K14(2), MAP3K2(1), MAP3K3(2), MAP3K4(9), MAP3K5(6), MAP3K6(8), MAP3K7(3), MAP3K8(2), MAP4K1(5), MAP4K2(4), MAP4K3(6), MAP4K4(9), MAPK1(3), MAPK10(4), MAPK11(4), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(1), MAPK7(6), MAPK8IP3(2), MAPK9(4), MAPKAPK2(4), MAPKAPK3(1), MAPKAPK5(4), MAPT(12), MEF2C(3), MKNK1(2), MKNK2(1), MOS(1), MRAS(1), MYC(2), NF1(14), NFATC2(4), NFATC4(5), NFKB1(7), NFKB2(2), NLK(3), NR4A1(4), NRAS(1), NTF3(1), NTRK1(5), NTRK2(5), PAK1(4), PAK2(8), PDGFA(2), PDGFB(1), PDGFRA(10), PDGFRB(2), PLA2G12A(2), PLA2G12B(2), PLA2G1B(1), PLA2G2A(1), PLA2G2D(3), PLA2G2E(1), PLA2G2F(6), PLA2G3(4), PLA2G4A(6), PLA2G6(6), PPM1B(3), PPP3CA(6), PPP3CB(5), PPP3CC(1), PPP3R1(1), PPP5C(4), PRKACA(2), PRKACB(3), PRKACG(1), PRKCA(2), PRKCG(2), PRKX(4), PTPN5(5), PTPN7(2), PTPRR(4), RAC1(1), RAC2(4), RAF1(2), RAP1A(2), RAPGEF2(8), RASA1(10), RASA2(4), RASGRF1(8), RASGRF2(8), RASGRP1(9), RASGRP2(3), RASGRP3(4), RASGRP4(6), RPS6KA1(4), RPS6KA2(6), RPS6KA3(10), RPS6KA4(1), RPS6KA5(3), RPS6KA6(9), SOS1(10), SOS2(8), SRF(1), STK3(6), STK4(5), STMN1(1), TAOK1(4), TAOK2(6), TAOK3(7), TGFB1(1), TGFB2(4), TGFB3(3), TGFBR1(5), TGFBR2(1), TNF(2), TNFRSF1A(2), TRAF6(1), ZAK(7) 89217364 830 177 824 354 204 187 98 221 114 6 1.000 1.000 1.000 120 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 235 ADCYAP1R1(3), ADORA1(3), ADORA2A(2), ADORA2B(4), ADORA3(3), ADRA1A(3), ADRA1B(2), ADRA2A(1), ADRA2B(1), ADRA2C(1), ADRB1(1), ADRB2(5), ADRB3(1), AGTR1(3), AVPR1B(2), BDKRB1(2), BDKRB2(4), BRS3(2), C3AR1(2), C5AR1(1), CALCR(4), CALCRL(1), CCKBR(4), CHRM2(5), CHRM3(4), CHRM4(1), CHRM5(3), CNR1(3), CNR2(1), CRHR1(3), CRHR2(6), CTSG(1), CYSLTR1(2), CYSLTR2(2), DRD2(2), DRD3(5), DRD5(8), EDNRA(3), EDNRB(2), F2(2), F2R(2), F2RL1(1), F2RL3(1), FPR1(2), FSHR(2), GABBR1(6), GABBR2(2), GABRA1(5), GABRA2(4), GABRA3(3), GABRA4(8), GABRA5(4), GABRA6(6), GABRB1(3), GABRB2(2), GABRB3(4), GABRD(1), GABRE(2), GABRG1(6), GABRG2(2), GABRG3(3), GABRP(1), GABRQ(7), GABRR1(7), GABRR2(9), GALR1(2), GH1(2), GH2(7), GHR(8), GHRHR(2), GHSR(2), GIPR(3), GLP1R(2), GLP2R(6), GLRA1(2), GLRA2(2), GLRA3(3), GLRB(4), GNRHR(2), GPR156(4), GPR35(2), GPR50(5), GPR63(5), GPR83(3), GRIA1(8), GRIA2(10), GRIA3(16), GRIA4(9), GRID1(3), GRID2(8), GRIK1(3), GRIK2(6), GRIK3(4), GRIK4(5), GRIK5(2), GRIN1(6), GRIN2A(6), GRIN2B(10), GRIN2C(4), GRIN2D(4), GRIN3A(7), GRIN3B(5), GRM1(8), GRM2(3), GRM3(6), GRM4(4), GRM5(5), GRM6(5), GRM7(8), GRM8(9), GZMA(3), HCRTR1(3), HCRTR2(2), HRH1(1), HRH2(3), HRH3(2), HRH4(3), HTR1A(1), HTR1B(1), HTR1D(2), HTR1E(2), HTR1F(3), HTR2A(2), HTR2B(4), HTR2C(7), HTR4(1), HTR5A(1), HTR6(4), HTR7(10), KISS1R(1), LEP(1), LEPR(7), LHB(3), LHCGR(7), LTB4R(1), MC1R(1), MC2R(4), MC3R(2), MC4R(2), MC5R(5), MCHR1(2), MCHR2(2), MTNR1A(5), NMBR(3), NMUR1(2), NMUR2(8), NPBWR1(2), NPBWR2(1), NPFFR1(1), NPFFR2(3), NPY1R(4), NPY2R(4), NPY5R(4), NR3C1(4), OPRK1(2), OPRL1(1), OPRM1(10), OXTR(2), P2RX1(2), P2RX2(2), P2RX3(3), P2RX4(1), P2RX5(2), P2RX7(3), P2RY1(5), P2RY10(1), P2RY13(2), P2RY2(2), P2RY4(4), P2RY6(1), P2RY8(4), PARD3(5), PPYR1(2), PRL(2), PRLHR(3), PRSS1(3), PRSS3(6), PTGDR(1), PTGER2(5), PTGER3(2), PTGER4(1), PTGFR(3), PTGIR(2), PTH2R(6), RXFP1(5), RXFP2(5), SCTR(1), SSTR2(2), SSTR3(6), SSTR4(2), SSTR5(1), TAAR1(2), TAAR2(3), TAAR5(2), TAAR6(2), TACR1(5), TACR2(6), TACR3(4), THRA(1), THRB(1), TRHR(5), TRPV1(6), TSHR(4), TSPO(1), UTS2R(1), VIPR1(2), VIPR2(4) 65967748 724 174 705 354 147 146 78 266 87 0 1.000 1.000 1.000 121 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(2), ACTN1(5), ACTN2(8), ACTN3(1), ACTN4(2), APC(12), APC2(3), ARAF(4), ARHGEF1(3), ARHGEF12(11), ARHGEF4(7), ARHGEF6(4), ARHGEF7(6), ARPC1A(2), ARPC1B(2), ARPC2(5), ARPC4(2), BAIAP2(3), BCAR1(3), BDKRB1(2), BDKRB2(4), BRAF(2), CDC42(2), CFL1(3), CFL2(2), CHRM2(5), CHRM3(4), CHRM4(1), CHRM5(3), CSK(2), CYFIP1(3), CYFIP2(16), DIAPH1(6), DIAPH2(6), DIAPH3(8), DOCK1(14), EGF(10), EGFR(7), EZR(5), F2(2), F2R(2), FGD3(6), FGF10(2), FGF11(1), FGF13(2), FGF14(4), FGF20(3), FGF21(1), FGF3(3), FGF5(2), FGF6(3), FGF8(1), FGF9(1), FGFR1(2), FGFR2(8), FGFR3(6), FGFR4(1), FN1(14), GIT1(2), GNA12(1), GNA13(2), GNG12(1), GSN(2), IQGAP1(10), IQGAP2(7), IQGAP3(5), ITGA1(7), ITGA10(10), ITGA11(10), ITGA2(7), ITGA2B(5), ITGA3(5), ITGA4(7), ITGA5(4), ITGA6(3), ITGA7(8), ITGA8(6), ITGA9(8), ITGAD(12), ITGAE(7), ITGAL(7), ITGAM(7), ITGAV(9), ITGAX(7), ITGB1(3), ITGB2(9), ITGB3(3), ITGB4(9), ITGB5(7), ITGB6(5), ITGB7(2), ITGB8(9), KRAS(4), LIMK1(2), LIMK2(6), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MOS(1), MRAS(1), MSN(6), MYH10(7), MYH14(12), MYH9(4), MYL5(1), MYL9(1), MYLK(4), MYLK2(4), MYLPF(1), NCKAP1(6), NCKAP1L(8), NRAS(1), PAK1(4), PAK2(8), PAK3(6), PAK4(3), PAK6(4), PAK7(9), PDGFA(2), PDGFB(1), PDGFRA(10), PDGFRB(2), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PIP4K2A(2), PIP4K2B(3), PIP4K2C(4), PIP5K1B(2), PIP5K1C(3), PPP1CA(3), PPP1CB(3), PPP1CC(1), PPP1R12A(8), PPP1R12B(5), PTK2(9), PXN(5), RAC1(1), RAC2(4), RAF1(2), RDX(4), ROCK1(7), ROCK2(8), SCIN(9), SLC9A1(1), SOS1(10), SOS2(8), SSH1(3), SSH2(5), SSH3(3), TIAM1(5), TIAM2(7), VAV1(6), VAV2(2), VAV3(7), VCL(4), WAS(2), WASF1(2), WASF2(2), WASL(2) 84953623 789 168 778 341 212 195 75 192 111 4 1.000 1.000 1.000 122 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(1), ACTG1(1), COL11A1(18), COL11A2(8), COL17A1(10), COL1A1(3), COL1A2(7), COL2A1(5), COL3A1(7), COL4A1(7), COL4A2(10), COL4A4(11), COL4A6(11), COL5A1(11), COL5A2(11), COL5A3(5), COL6A1(7), COL6A2(6), COL6A3(20), COL6A6(27), COMP(2), DES(2), DSC1(4), DSC2(7), DSC3(4), DSG1(11), DSG2(6), DSG3(8), DSG4(8), FN1(14), GJA1(4), GJA10(3), GJA3(2), GJA5(2), GJA8(5), GJA9(1), GJB1(1), GJB4(1), GJB5(2), GJB7(5), GJC1(2), GJD2(1), IBSP(8), ITGA6(3), ITGB4(9), KRT1(5), KRT10(1), KRT12(1), KRT13(2), KRT14(5), KRT15(5), KRT16(2), KRT17(4), KRT18(1), KRT19(2), KRT2(5), KRT20(1), KRT23(4), KRT24(4), KRT25(2), KRT27(6), KRT28(2), KRT3(1), KRT31(3), KRT32(7), KRT33A(1), KRT33B(3), KRT34(4), KRT35(9), KRT36(5), KRT37(2), KRT38(5), KRT39(2), KRT4(1), KRT40(11), KRT5(7), KRT6A(2), KRT6B(5), KRT6C(3), KRT7(4), KRT71(5), KRT72(6), KRT73(5), KRT74(1), KRT75(5), KRT76(6), KRT77(3), KRT78(6), KRT79(7), KRT8(1), KRT81(4), KRT82(4), KRT83(4), KRT84(3), KRT85(5), KRT86(4), KRT9(1), LAMA1(30), LAMA2(16), LAMA3(20), LAMA4(11), LAMA5(18), LAMB1(5), LAMB2(4), LAMB3(4), LAMB4(12), LAMC1(16), LAMC2(4), LAMC3(7), LMNA(3), LMNB1(5), LMNB2(4), NES(9), RELN(12), SPP1(1), THBS1(3), THBS2(5), THBS3(5), THBS4(3), TNC(11), TNN(12), TNR(11), TNXB(23), VIM(6), VTN(2), VWF(10) 76000641 770 166 756 390 168 148 103 244 98 9 1.000 1.000 1.000 123 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(4), CD36(1), CD44(3), CD47(1), COL11A1(18), COL11A2(8), COL1A1(3), COL1A2(7), COL2A1(5), COL3A1(7), COL4A1(7), COL4A2(10), COL4A4(11), COL4A6(11), COL5A1(11), COL5A2(11), COL5A3(5), COL6A1(7), COL6A2(6), COL6A3(20), COL6A6(27), FN1(14), FNDC1(9), FNDC3A(4), GP5(1), GP6(8), HMMR(5), HSPG2(20), IBSP(8), ITGA1(7), ITGA10(10), ITGA11(10), ITGA2(7), ITGA2B(5), ITGA3(5), ITGA4(7), ITGA5(4), ITGA6(3), ITGA7(8), ITGA8(6), ITGA9(8), ITGAV(9), ITGB1(3), ITGB3(3), ITGB4(9), ITGB5(7), ITGB6(5), ITGB7(2), ITGB8(9), LAMA1(30), LAMA2(16), LAMA3(20), LAMA4(11), LAMA5(18), LAMB1(5), LAMB2(4), LAMB3(4), LAMB4(12), LAMC1(16), LAMC2(4), LAMC3(7), RELN(12), SDC3(1), SPP1(1), SV2A(3), SV2B(3), SV2C(3), THBS1(3), THBS2(5), THBS3(5), THBS4(3), TNC(11), TNN(12), TNR(11), TNXB(23), VTN(2), VWF(10) 69014155 634 161 624 338 144 132 74 192 82 10 1.000 1.000 1.000 124 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ADCY1(7), ADCY2(10), ADCY3(7), ADCY4(6), ADCY5(5), ADCY6(9), ADCY7(3), ADCY8(12), ADCY9(9), ADRA1A(3), ADRA1B(2), ADRA1D(3), ADRB1(1), ADRB2(5), ADRB3(1), ANXA6(3), ARRB1(2), ARRB2(2), ATP1A4(8), ATP1B1(2), ATP1B2(1), ATP1B3(3), ATP2A2(2), ATP2A3(3), ATP2B1(8), ATP2B2(6), ATP2B3(3), CACNA1A(7), CACNA1B(15), CACNA1C(8), CACNA1D(9), CACNA1E(28), CACNA1S(7), CACNB1(3), CALM1(1), CALR(6), CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(1), CASQ1(3), CASQ2(3), CHRM2(5), CHRM3(4), CHRM4(1), CHRM5(3), GJA1(4), GJA5(2), GJB1(1), GJB4(1), GJB5(2), GNAI2(2), GNAI3(1), GNAO1(2), GNB1(4), GNB2(2), GNB4(1), GNB5(6), GNG12(1), GNG5(1), GNGT1(1), GRK4(3), GRK5(2), GRK6(2), ITPR1(18), ITPR2(19), ITPR3(15), KCNJ3(1), KCNJ5(1), MIB1(4), PLCB3(5), PRKACA(2), PRKACB(3), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(2), PRKCD(4), PRKCG(2), PRKCH(2), PRKCQ(2), PRKCZ(3), PRKD1(7), RGS10(1), RGS11(4), RGS14(4), RGS16(4), RGS17(1), RGS18(2), RGS20(2), RGS3(3), RGS4(2), RGS5(1), RGS6(4), RGS7(5), RGS9(5), RYR1(26), RYR2(47), RYR3(32), SFN(1), SLC8A1(9), SLC8A3(2), USP5(6), YWHAB(2), YWHAH(1) 57980811 540 159 537 240 117 123 49 188 60 3 1.000 1.000 1.000 125 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(1), ABLIM1(4), ABLIM2(2), ABLIM3(2), ARHGEF12(11), CDC42(2), CDK5(1), CFL1(3), CFL2(2), CXCL12(2), CXCR4(2), DCC(12), DPYSL2(2), DPYSL5(4), EFNA1(1), EFNA3(2), EFNA4(1), EFNA5(2), EFNB2(3), EPHA1(6), EPHA2(5), EPHA3(10), EPHA4(3), EPHA5(10), EPHA6(10), EPHA7(8), EPHA8(4), EPHB1(6), EPHB2(7), EPHB3(7), EPHB4(1), FES(2), FYN(2), GNAI1(4), GNAI2(2), GNAI3(1), GSK3B(6), ITGB1(3), KRAS(4), L1CAM(5), LIMK1(2), LIMK2(6), LRRC4C(5), MAPK1(3), MAPK3(1), MET(2), NCK1(1), NCK2(2), NFAT5(13), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), NGEF(3), NRAS(1), NRP1(3), NTN1(1), NTN4(4), NTNG1(2), PAK1(4), PAK2(8), PAK3(6), PAK4(3), PAK6(4), PAK7(9), PLXNA1(10), PLXNA2(10), PLXNA3(7), PLXNB1(7), PLXNB2(10), PLXNB3(12), PLXNC1(11), PPP3CA(6), PPP3CB(5), PPP3CC(1), PPP3R1(1), PTK2(9), RAC1(1), RAC2(4), RASA1(10), RGS3(3), RND1(1), ROBO1(12), ROBO2(10), ROBO3(3), ROCK1(7), ROCK2(8), SEMA3A(12), SEMA3C(10), SEMA3D(16), SEMA3E(8), SEMA3F(5), SEMA3G(2), SEMA4A(4), SEMA4B(2), SEMA4C(2), SEMA4D(5), SEMA4F(4), SEMA4G(1), SEMA5A(1), SEMA5B(6), SEMA6A(8), SEMA6B(2), SEMA6C(4), SEMA6D(11), SEMA7A(5), SLIT1(8), SLIT2(15), SLIT3(7), SRGAP1(9), SRGAP2(2), SRGAP3(7), UNC5B(1), UNC5C(3), UNC5D(10) 59796352 582 159 580 267 116 128 69 187 80 2 1.000 1.000 1.000 126 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(5), CADM1(6), CADM3(1), CD2(2), CD22(9), CD226(3), CD276(1), CD4(3), CD40(4), CD58(2), CD6(4), CD80(1), CD86(4), CD8A(1), CD8B(4), CD99(4), CDH1(4), CDH15(5), CDH2(4), CDH3(5), CDH4(5), CDH5(5), CLDN1(1), CLDN10(1), CLDN16(3), CLDN17(1), CLDN18(3), CLDN19(1), CLDN2(1), CLDN20(2), CLDN23(1), CLDN3(1), CLDN4(1), CLDN5(1), CLDN6(2), CLDN7(2), CLDN8(2), CNTN1(8), CNTN2(5), CNTNAP1(1), CNTNAP2(8), CTLA4(3), F11R(1), GLG1(7), HLA-A(11), HLA-B(6), HLA-C(1), HLA-DMA(4), HLA-DMB(4), HLA-DOA(1), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(8), HLA-DQA1(4), HLA-DQA2(1), HLA-DQB1(3), HLA-DRB1(4), HLA-DRB5(3), HLA-E(4), HLA-G(1), ICAM1(2), ICAM3(2), ICOSLG(2), ITGA4(7), ITGA6(3), ITGA8(6), ITGA9(8), ITGAL(7), ITGAM(7), ITGAV(9), ITGB1(3), ITGB2(9), ITGB7(2), ITGB8(9), JAM2(3), JAM3(3), L1CAM(5), MADCAM1(4), MAG(3), NCAM1(6), NCAM2(4), NEGR1(4), NEO1(7), NFASC(7), NLGN1(11), NLGN2(1), NLGN3(3), NRCAM(10), NRXN1(7), NRXN2(5), NRXN3(7), OCLN(1), PDCD1(2), PDCD1LG2(2), PECAM1(1), PTPRC(9), PTPRF(4), PTPRM(16), PVR(1), PVRL1(2), PVRL2(4), PVRL3(3), SDC3(1), SELE(2), SELL(2), SELP(8), SELPLG(3), SIGLEC1(10), SPN(3), VCAM1(3), VCAN(18) 44497137 458 152 451 226 117 96 56 132 57 0 1.000 1.000 1.000 127 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 251 ACVR1(4), ACVR1B(3), ACVR2A(11), ACVR2B(4), AMH(1), AMHR2(1), BMP2(3), BMP7(3), BMPR1A(1), BMPR1B(2), BMPR2(8), CCL1(2), CCL11(1), CCL13(1), CCL14(1), CCL15(4), CCL16(1), CCL18(1), CCL19(1), CCL23(1), CCL24(1), CCL25(1), CCL26(1), CCL3(1), CCL8(2), CCR1(3), CCR2(4), CCR3(3), CCR5(2), CCR6(4), CCR7(4), CCR8(1), CCR9(2), CD27(1), CD40(4), CD70(1), CLCF1(1), CNTFR(2), CRLF2(3), CSF1(1), CSF1R(3), CSF2(2), CSF2RA(4), CSF2RB(3), CSF3R(1), CX3CL1(1), CX3CR1(4), CXCL1(1), CXCL12(2), CXCL14(1), CXCL16(1), CXCL5(1), CXCR3(1), CXCR4(2), CXCR6(2), EDA(4), EDA2R(1), EDAR(3), EGF(10), EGFR(7), FAS(5), FASLG(2), FLT1(11), FLT3(10), FLT3LG(2), FLT4(9), GDF5(4), GH1(2), GH2(7), GHR(8), HGF(9), IFNA13(1), IFNA14(2), IFNA16(2), IFNA17(6), IFNA2(2), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(5), IFNA8(2), IFNAR1(5), IFNAR2(1), IFNB1(1), IFNG(3), IFNGR1(5), IFNGR2(2), IFNW1(2), IL10RA(7), IL10RB(2), IL11RA(1), IL12A(6), IL12B(2), IL12RB1(5), IL12RB2(10), IL13RA1(5), IL15RA(1), IL17RA(2), IL17RB(1), IL18(2), IL18R1(3), IL18RAP(5), IL19(1), IL1A(3), IL1B(2), IL1R1(4), IL1R2(2), IL1RAP(4), IL2(1), IL20(1), IL20RA(4), IL21(1), IL21R(8), IL22(2), IL22RA1(1), IL23A(1), IL23R(3), IL2RA(2), IL2RB(3), IL2RG(1), IL3(2), IL4(1), IL4R(4), IL5RA(2), IL6(3), IL6R(1), IL7(2), IL7R(10), IL9(1), IL9R(5), INHBA(2), INHBC(3), INHBE(1), KDR(13), KIT(10), KITLG(2), LEP(1), LEPR(7), LIF(1), LIFR(6), LTA(2), LTBR(1), MET(2), MPL(1), NGFR(1), OSMR(3), PDGFB(1), PDGFC(5), PDGFRA(10), PDGFRB(2), PF4V1(1), PLEKHO2(2), PPBP(1), PRL(2), RELT(3), TGFB1(1), TGFB2(4), TGFB3(3), TGFBR1(5), TGFBR2(1), TNF(2), TNFRSF10A(4), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(5), TNFRSF11A(1), TNFRSF11B(5), TNFRSF13B(1), TNFRSF14(2), TNFRSF17(1), TNFRSF18(1), TNFRSF19(1), TNFRSF1A(2), TNFRSF1B(3), TNFRSF21(6), TNFRSF25(3), TNFRSF4(3), TNFRSF6B(2), TNFRSF8(3), TNFSF10(2), TNFSF11(1), TNFSF13(2), TNFSF13B(2), TNFSF14(1), TNFSF18(1), TNFSF8(1), TPO(11), TSLP(1), VEGFB(2), VEGFC(5), XCL2(1), XCR1(2) 53008347 568 151 561 197 110 127 65 177 86 3 0.770 1.000 1.000 128 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(10), ACACB(14), AKT1(2), AKT2(7), AKT3(4), ARAF(4), BRAF(2), CALM1(1), CALML6(1), CBL(8), CBLB(4), EIF4EBP1(1), EXOC7(5), FASN(18), FBP1(2), FBP2(1), FLOT1(6), FLOT2(1), G6PC(4), G6PC2(4), GCK(3), GSK3B(6), GYS1(2), GYS2(5), IKBKB(6), INPP5D(3), INSR(11), IRS1(4), IRS2(2), IRS4(9), KRAS(4), LIPE(6), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK10(4), MAPK3(1), MAPK9(4), MKNK1(2), MKNK2(1), NRAS(1), PCK1(6), PDE3A(7), PDE3B(9), PDPK1(2), PFKL(3), PFKM(2), PFKP(6), PHKA1(10), PHKA2(5), PHKB(11), PHKG1(1), PHKG2(4), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PKLR(1), PPARGC1A(4), PPP1CA(3), PPP1CB(3), PPP1CC(1), PPP1R3A(6), PPP1R3B(1), PPP1R3C(2), PRKAA1(4), PRKAA2(4), PRKAB1(1), PRKAB2(1), PRKACA(2), PRKACB(3), PRKACG(1), PRKAG2(3), PRKAG3(2), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCI(1), PRKCZ(3), PRKX(4), PTPN1(2), PTPRF(4), PYGB(1), PYGL(8), PYGM(9), RAF1(2), RAPGEF1(7), RHOQ(1), RPS6(1), RPS6KB1(5), RPS6KB2(3), SH2B2(1), SHC1(5), SHC2(1), SHC4(5), SLC2A4(1), SOCS4(1), SORBS1(5), SOS1(10), SOS2(8), SREBF1(4), TRIP10(3), TSC1(13), TSC2(15) 48774293 467 149 463 184 128 107 52 104 73 3 0.962 1.000 1.000 129 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 137 ACTA1(2), ACTA2(1), ADCY1(7), ADCY2(10), ADCY3(7), ADCY4(6), ADCY5(5), ADCY6(9), ADCY7(3), ADCY8(12), ADCY9(9), ARRB1(2), ARRB2(2), ATF1(2), ATF2(1), ATF3(2), ATF4(6), ATF5(1), ATP2A2(2), ATP2A3(3), CALCA(3), CALM1(1), CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), CNN2(1), CORIN(6), CREB3(2), CRHR1(3), DGKZ(7), ETS2(2), FOS(2), GABPA(1), GABPB2(2), GJA1(4), GNB1(4), GNB2(2), GNB4(1), GNB5(6), GNG12(1), GNG5(1), GNGT1(1), GRK4(3), GRK5(2), GRK6(2), GUCA2A(1), GUCA2B(2), GUCY1A3(3), IGFBP2(1), IGFBP3(1), IGFBP4(2), IL1B(2), IL6(3), ITPR1(18), ITPR2(19), ITPR3(15), JUN(1), MIB1(4), MYLK2(4), NFKB1(7), NOS1(15), NOS3(8), OXTR(2), PDE4B(3), PDE4D(8), PLCB3(5), PLCD1(1), PLCG1(10), PLCG2(16), PRKACA(2), PRKACB(3), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(2), PRKCD(4), PRKCH(2), PRKCQ(2), PRKCZ(3), PRKD1(7), RGS10(1), RGS11(4), RGS14(4), RGS16(4), RGS17(1), RGS18(2), RGS20(2), RGS3(3), RGS4(2), RGS5(1), RGS6(4), RGS7(5), RGS9(5), RYR1(26), RYR2(47), RYR3(32), SFN(1), SLC8A1(9), SP1(2), TNXB(23), USP5(6), YWHAB(2), YWHAH(1) 53219325 530 148 525 228 110 119 54 176 67 4 1.000 1.000 1.000 130 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(7), ADCY2(10), ADCY3(7), ADCY4(6), ADCY5(5), ADCY6(9), ADCY7(3), ADCY8(12), ADCY9(9), ADRB1(1), DRD2(2), EGF(10), EGFR(7), GJA1(4), GJD2(1), GNAI1(4), GNAI2(2), GNAI3(1), GNAS(9), GRM1(8), GRM5(5), GUCY1A2(5), GUCY1A3(3), GUCY1B3(7), GUCY2C(6), GUCY2D(3), GUCY2F(9), HTR2A(2), HTR2B(4), HTR2C(7), ITPR1(18), ITPR2(19), ITPR3(15), KRAS(4), MAP2K1(5), MAP2K2(3), MAP2K5(1), MAP3K2(1), MAPK1(3), MAPK3(1), MAPK7(6), NPR1(3), NPR2(6), NRAS(1), PDGFA(2), PDGFB(1), PDGFC(5), PDGFD(2), PDGFRA(10), PDGFRB(2), PLCB1(11), PLCB2(4), PLCB3(5), PLCB4(16), PRKACA(2), PRKACB(3), PRKACG(1), PRKCA(2), PRKCG(2), PRKG1(5), PRKG2(11), PRKX(4), RAF1(2), SOS1(10), SOS2(8), SRC(2), TJP1(9), TUBA1A(1), TUBA1C(1), TUBA3C(5), TUBA3D(3), TUBA3E(17), TUBA4A(1), TUBA8(4), TUBAL3(3), TUBB(1), TUBB1(3), TUBB2A(1), TUBB2B(1), TUBB3(1), TUBB6(1), TUBB8(3) 40250261 419 146 404 170 102 96 43 121 53 4 0.993 1.000 1.000 131 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(2), AKT2(7), AKT3(4), CBL(8), CBLB(4), CCND1(1), CCND2(1), CISH(2), CLCF1(1), CNTFR(2), CREBBP(12), CRLF2(3), CSF2(2), CSF2RA(4), CSF2RB(3), CSF3R(1), EP300(7), GH1(2), GH2(7), GHR(8), IFNA13(1), IFNA14(2), IFNA16(2), IFNA17(6), IFNA2(2), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(5), IFNA8(2), IFNAR1(5), IFNAR2(1), IFNB1(1), IFNG(3), IFNGR1(5), IFNGR2(2), IFNW1(2), IL10RA(7), IL10RB(2), IL11RA(1), IL12A(6), IL12B(2), IL12RB1(5), IL12RB2(10), IL13RA1(5), IL13RA2(5), IL15RA(1), IL19(1), IL2(1), IL20(1), IL20RA(4), IL21(1), IL21R(8), IL22(2), IL22RA1(1), IL23A(1), IL23R(3), IL2RA(2), IL2RB(3), IL2RG(1), IL3(2), IL4(1), IL4R(4), IL5RA(2), IL6(3), IL6R(1), IL7(2), IL7R(10), IL9(1), IL9R(5), IRF9(2), JAK1(8), JAK2(9), JAK3(5), LEP(1), LEPR(7), LIF(1), LIFR(6), MPL(1), MYC(2), OSMR(3), PIAS1(1), PIAS2(3), PIAS4(1), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PIM1(2), PRL(2), PTPN11(2), PTPN6(2), SOCS4(1), SOCS5(1), SOCS7(1), SOS1(10), SOS2(8), SPRY1(1), SPRY2(2), SPRY3(2), SPRY4(1), STAM(3), STAM2(1), STAT1(7), STAT2(6), STAT3(5), STAT4(7), STAT5A(2), STAT5B(3), STAT6(6), TPO(11), TSLP(1), TYK2(7) 43365672 421 146 413 158 93 99 46 121 61 1 0.932 1.000 1.000 132 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 128 ACTB(1), ACTG1(1), ACTN1(5), ACTN2(8), ACTN3(1), ACTN4(2), AKT1(2), AKT2(7), AKT3(4), AMOTL1(4), ASH1L(11), CASK(5), CDC42(2), CGN(4), CLDN1(1), CLDN10(1), CLDN16(3), CLDN17(1), CLDN18(3), CLDN19(1), CLDN2(1), CLDN20(2), CLDN23(1), CLDN3(1), CLDN4(1), CLDN5(1), CLDN6(2), CLDN7(2), CLDN8(2), CRB3(1), CSNK2A1(2), CSNK2A2(1), CTNNA1(1), CTNNA2(10), CTNNA3(3), CTTN(5), EPB41(3), EPB41L1(4), EPB41L2(5), EPB41L3(8), EXOC3(5), EXOC4(7), F11R(1), GNAI1(4), GNAI2(2), GNAI3(1), IGSF5(7), INADL(21), JAM2(3), JAM3(3), KRAS(4), LLGL1(2), LLGL2(6), MAGI1(6), MAGI2(8), MAGI3(7), MLLT4(7), MPDZ(13), MPP5(4), MRAS(1), MYH1(12), MYH10(7), MYH11(10), MYH13(8), MYH14(12), MYH15(16), MYH2(14), MYH3(13), MYH4(11), MYH6(10), MYH7(16), MYH7B(3), MYH8(10), MYH9(4), MYL5(1), MYL9(1), MYLPF(1), NRAS(1), OCLN(1), PARD3(5), PARD6B(2), PPP2CA(4), PPP2CB(3), PPP2R1A(4), PPP2R1B(3), PPP2R2B(3), PPP2R2C(4), PPP2R3A(6), PPP2R3B(5), PPP2R4(4), PRKCA(2), PRKCD(4), PRKCG(2), PRKCH(2), PRKCI(1), PRKCQ(2), PRKCZ(3), RAB3B(1), SPTAN1(9), SRC(2), SYMPK(4), TJAP1(2), TJP1(9), TJP2(8), VAPA(1), YES1(4), ZAK(7) 57627277 492 143 486 250 110 118 52 141 69 2 1.000 1.000 1.000 133 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(4), BRAF(2), CACNA1A(7), CRHR1(3), GNA12(1), GNA13(2), GNAI1(4), GNAI2(2), GNAI3(1), GNAO1(2), GNAS(9), GRIA1(8), GRIA2(10), GRIA3(16), GRID2(8), GRM1(8), GRM5(5), GUCY1A2(5), GUCY1A3(3), GUCY1B3(7), GUCY2C(6), GUCY2D(3), GUCY2F(9), IGF1(1), IGF1R(12), ITPR1(18), ITPR2(19), ITPR3(15), KRAS(4), LYN(3), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), NOS1(15), NOS3(8), NPR1(3), NPR2(6), NRAS(1), PLA2G12A(2), PLA2G12B(2), PLA2G1B(1), PLA2G2A(1), PLA2G2D(3), PLA2G2E(1), PLA2G2F(6), PLA2G3(4), PLA2G4A(6), PLA2G6(6), PLCB1(11), PLCB2(4), PLCB3(5), PLCB4(16), PPP2CA(4), PPP2CB(3), PPP2R1A(4), PPP2R1B(3), PPP2R2B(3), PPP2R2C(4), PRKCA(2), PRKCG(2), PRKG1(5), PRKG2(11), RAF1(2), RYR1(26) 33804427 379 141 370 158 87 86 40 123 42 1 0.997 1.000 1.000 134 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(2), AKT3(4), BCAR1(3), CAPN1(3), CAPN10(1), CAPN11(11), CAPN2(1), CAPN3(5), CAPN5(4), CAPN6(1), CAPN7(4), CAPN9(3), CAPNS1(1), CAV1(1), CAV2(3), CDC42(2), CSK(2), DOCK1(14), FYN(2), GIT2(3), ILK(1), ITGA10(10), ITGA11(10), ITGA2(7), ITGA2B(5), ITGA3(5), ITGA4(7), ITGA5(4), ITGA6(3), ITGA7(8), ITGA8(6), ITGA9(8), ITGAD(12), ITGAE(7), ITGAL(7), ITGAM(7), ITGAV(9), ITGAX(7), ITGB1(3), ITGB2(9), ITGB3(3), ITGB4(9), ITGB5(7), ITGB6(5), ITGB7(2), ITGB8(9), MAP2K1(5), MAP2K2(3), MAP2K6(1), MAPK10(4), MAPK12(2), MAPK4(5), MAPK6(7), MAPK7(6), MYLK2(4), PAK1(4), PAK2(8), PAK3(6), PAK4(3), PAK6(4), PDPK1(2), PIK3R2(4), PTK2(9), PXN(5), RAC1(1), RAC2(4), RAPGEF1(7), RHO(2), ROCK1(7), ROCK2(8), SDCCAG8(6), SEPP1(3), SHC1(5), SORBS1(5), SOS1(10), SRC(2), TLN1(12), TNS1(14), VASP(3), VAV2(2), VAV3(7), VCL(4), ZYX(2) 41469707 426 141 420 173 113 101 41 100 70 1 0.992 1.000 1.000 135 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 125 ARAF(4), BID(2), BRAF(2), CASP3(2), CD244(4), CD247(1), CD48(1), CSF2(2), FAS(5), FASLG(2), FCGR3A(1), FCGR3B(6), FYN(2), GZMB(1), HLA-A(11), HLA-B(6), HLA-C(1), HLA-E(4), HLA-G(1), ICAM1(2), IFNA13(1), IFNA14(2), IFNA16(2), IFNA17(6), IFNA2(2), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(5), IFNA8(2), IFNAR1(5), IFNAR2(1), IFNB1(1), IFNG(3), IFNGR1(5), IFNGR2(2), ITGAL(7), ITGB2(9), KIR2DL1(4), KIR3DL1(2), KLRC1(1), KLRC2(1), KLRD1(1), KRAS(4), LCK(5), LCP2(4), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MICA(10), MICB(1), NCR1(2), NCR2(4), NCR3(1), NFAT5(13), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), NRAS(1), PAK1(4), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PLCG1(10), PLCG2(16), PPP3CA(6), PPP3CB(5), PPP3CC(1), PPP3R1(1), PRF1(4), PRKCA(2), PRKCG(2), PTK2B(8), PTPN11(2), PTPN6(2), RAC1(1), RAC2(4), RAF1(2), SH2D1A(2), SH2D1B(1), SH3BP2(4), SHC1(5), SHC2(1), SHC4(5), SOS1(10), SOS2(8), SYK(4), TNF(2), TNFRSF10A(4), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(5), TNFSF10(2), TYROBP(1), ULBP1(1), ULBP2(1), VAV1(6), VAV2(2), VAV3(7), ZAP70(3) 34011566 395 139 386 135 92 93 42 117 49 2 0.723 1.000 1.000 136 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 143 APC(12), APC2(3), AXIN1(14), AXIN2(8), BTRC(6), CACYBP(1), CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), CCND1(1), CCND2(1), CER1(3), CHD8(8), CREBBP(12), CSNK1A1(1), CSNK1A1L(4), CSNK1E(3), CSNK2A1(2), CSNK2A2(1), CTBP1(2), CTBP2(5), CUL1(3), CXXC4(1), DAAM1(4), DAAM2(3), DKK1(2), DKK2(4), DKK4(1), DVL1(1), DVL2(5), EP300(7), FBXW11(8), FOSL1(1), FZD1(1), FZD10(5), FZD2(3), FZD3(4), FZD4(1), FZD5(2), FZD6(4), FZD7(1), FZD8(2), FZD9(6), GSK3B(6), JUN(1), LEF1(4), LRP5(2), LRP6(6), MAP3K7(3), MAPK10(4), MAPK9(4), MMP7(2), MYC(2), NFAT5(13), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), NKD1(2), NKD2(1), NLK(3), PLCB1(11), PLCB2(4), PLCB3(5), PLCB4(16), PPARD(1), PPP2CA(4), PPP2CB(3), PPP2R1A(4), PPP2R1B(3), PPP2R2B(3), PPP2R2C(4), PPP3CA(6), PPP3CB(5), PPP3CC(1), PPP3R1(1), PRICKLE1(5), PRICKLE2(10), PRKACA(2), PRKACB(3), PRKACG(1), PRKCA(2), PRKCG(2), PRKX(4), PSEN1(2), RAC1(1), RAC2(4), ROCK1(7), ROCK2(8), RUVBL1(1), SENP2(5), SFRP2(1), SFRP4(3), SFRP5(2), SIAH1(6), SMAD2(3), SMAD3(5), TBL1X(1), TBL1XR1(5), TBL1Y(3), TCF7(5), TCF7L1(5), TCF7L2(6), VANGL1(3), VANGL2(1), WIF1(5), WNT1(3), WNT10B(1), WNT16(2), WNT2(3), WNT3A(1), WNT4(1), WNT5B(1), WNT6(2), WNT7A(2), WNT7B(1), WNT8A(2), WNT8B(1), WNT9B(1) 47578382 441 138 438 187 90 98 38 121 90 4 1.000 1.000 1.000 137 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(3), ADORA2A(2), ADORA2B(4), ADORA3(3), ADRA1A(3), ADRA1B(2), ADRA1D(3), ADRA2A(1), ADRA2C(1), ADRB1(1), ADRB2(5), ADRB3(1), AGTR1(3), AVPR1B(2), BDKRB1(2), BDKRB2(4), BRS3(2), C3AR1(2), CCKBR(4), CCR1(3), CCR2(4), CCR3(3), CCR5(2), CCR6(4), CCR7(4), CCR8(1), CCR9(2), CCRL2(2), CHML(3), CHRM2(5), CHRM3(4), CHRM4(1), CHRM5(3), CMKLR1(2), CNR1(3), CNR2(1), CX3CR1(4), CXCR3(1), CXCR4(2), DRD2(2), DRD3(5), DRD5(8), EDNRA(3), EDNRB(2), F2R(2), F2RL1(1), F2RL3(1), FPR1(2), FSHR(2), GALR1(2), GALT(1), GHSR(2), GNB2L1(2), GPR17(3), GPR173(5), GPR174(4), GPR3(1), GPR35(2), GPR37(1), GPR4(2), GPR50(5), GPR63(5), GPR83(3), GPR85(4), GPR87(3), HCRTR1(3), HCRTR2(2), HRH1(1), HRH2(3), HRH3(2), HTR1A(1), HTR1B(1), HTR1D(2), HTR1E(2), HTR1F(3), HTR2A(2), HTR2B(4), HTR2C(7), HTR4(1), HTR5A(1), HTR6(4), HTR7(10), LHCGR(7), LTB4R(1), MC1R(1), MC3R(2), MC4R(2), MC5R(5), MTNR1A(5), NMBR(3), NMUR1(2), NMUR2(8), NPY1R(4), NPY2R(4), NPY5R(4), OPN3(1), OPRK1(2), OPRL1(1), OPRM1(10), OR10A5(5), OR11A1(2), OR12D3(4), OR1C1(6), OR1F1(1), OR1Q1(1), OR2H1(2), OR5V1(3), OR7A5(1), OR7C1(7), OR8B8(3), OXTR(2), P2RY1(5), P2RY10(1), P2RY12(4), P2RY13(2), P2RY2(2), P2RY6(1), PPYR1(2), PTGDR(1), PTGER2(5), PTGER4(1), PTGFR(3), PTGIR(2), RGR(1), RHO(2), RRH(3), SSTR2(2), SSTR3(6), SSTR4(2), SUCNR1(1), TRHR(5) 35558804 374 136 360 188 90 72 31 149 32 0 1.000 1.000 1.000 138 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(1), ADCY1(7), ADCY2(10), ADCY3(7), ADCY4(6), ADCY5(5), ADCY6(9), ADCY7(3), ADCY8(12), ADCY9(9), ADK(3), ADSL(1), ADSS(3), ADSSL1(2), AK2(1), AK5(1), AK7(9), ALLC(5), AMPD1(7), AMPD2(4), AMPD3(4), ATIC(1), ENPP1(4), ENPP3(8), ENTPD1(6), ENTPD2(2), ENTPD3(1), ENTPD4(2), ENTPD5(4), ENTPD6(4), GART(10), GDA(2), GMPR(1), GMPR2(3), GMPS(3), GUCY1A2(5), GUCY1A3(3), GUCY1B3(7), GUCY2C(6), GUCY2D(3), GUCY2F(9), GUK1(4), HPRT1(1), IMPDH1(2), IMPDH2(3), NME1(1), NME4(1), NME6(1), NPR1(3), NPR2(6), NT5C(1), NT5C1A(2), NT5C1B(2), NT5C2(6), NUDT5(1), PAICS(2), PAPSS1(4), PAPSS2(5), PDE10A(9), PDE11A(8), PDE1A(2), PDE1C(11), PDE2A(6), PDE3B(9), PDE4A(9), PDE4B(3), PDE4C(2), PDE4D(8), PDE5A(5), PDE7A(5), PDE7B(1), PDE8A(8), PDE8B(3), PDE9A(3), PFAS(7), PKLR(1), PNPT1(4), POLA1(10), POLA2(1), POLD1(5), POLD3(1), POLE(9), POLE2(7), POLE3(2), POLR1A(10), POLR1B(3), POLR1C(1), POLR1D(1), POLR2A(10), POLR2B(8), POLR2C(1), POLR2E(2), POLR2G(2), POLR2H(1), POLR2I(2), POLR3A(9), POLR3B(4), POLR3K(1), PPAT(3), PRIM1(2), PRIM2(2), PRPS1(1), PRPS1L1(2), PRPS2(3), RFC5(3), RRM1(5), RRM2(2), XDH(13), ZNRD1(1) 49625982 469 135 467 228 116 119 38 126 67 3 1.000 1.000 1.000 139 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 57 ASH1L(11), ASH2L(2), CARM1(2), CTCFL(4), DOT1L(9), EED(4), EHMT1(5), EHMT2(7), EZH1(5), EZH2(3), FBXO11(9), HCFC1(5), HSF4(3), JMJD6(1), KDM6A(4), MEN1(3), MLL(19), MLL2(26), MLL3(38), MLL4(20), MLL5(10), NSD1(14), OGT(4), PAXIP1(3), PPP1CA(3), PPP1CB(3), PPP1CC(1), PRDM2(13), PRDM6(3), PRDM7(3), PRDM9(6), PRMT1(6), PRMT5(4), PRMT6(4), PRMT7(1), PRMT8(3), RBBP5(3), SATB1(11), SETD1A(7), SETD1B(3), SETD2(11), SETD7(3), SETD8(2), SETDB1(5), SETDB2(8), SETMAR(2), SMYD3(2), SUV39H1(1), SUV39H2(3), SUV420H1(6), SUV420H2(1), SUZ12(3), WHSC1(4), WHSC1L1(13) 38056612 349 134 340 147 68 69 36 100 69 7 0.992 1.000 1.000 140 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(7), ADCY2(10), ADCY3(7), ADCY4(6), ADCY5(5), ADCY6(9), ADCY7(3), ADCY8(12), ADCY9(9), ATF4(6), CACNA1C(8), CACNA1D(9), CACNA1F(7), CACNA1S(7), CALM1(1), CALML6(1), CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), CDC42(2), EGFR(7), GNAS(9), GNRH1(1), GNRH2(1), GNRHR(2), HBEGF(1), ITPR1(18), ITPR2(19), ITPR3(15), JUN(1), KRAS(4), LHB(3), MAP2K1(5), MAP2K2(3), MAP2K4(4), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K2(1), MAP3K3(2), MAP3K4(9), MAPK1(3), MAPK10(4), MAPK11(4), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(1), MAPK7(6), MAPK9(4), MMP14(4), MMP2(1), NRAS(1), PLA2G12A(2), PLA2G12B(2), PLA2G1B(1), PLA2G2A(1), PLA2G2D(3), PLA2G2E(1), PLA2G2F(6), PLA2G3(4), PLA2G4A(6), PLA2G6(6), PLCB1(11), PLCB2(4), PLCB3(5), PLCB4(16), PLD1(6), PLD2(5), PRKACA(2), PRKACB(3), PRKACG(1), PRKCA(2), PRKCD(4), PRKX(4), PTK2B(8), RAF1(2), SOS1(10), SOS2(8), SRC(2) 39502780 396 134 391 160 105 78 40 110 58 5 0.997 1.000 1.000 141 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(1), ABL2(3), AKT1(2), AKT2(7), AKT3(4), ARAF(4), BRAF(2), CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), CBL(8), CBLB(4), CDKN1A(6), CDKN1B(2), EGF(10), EGFR(7), EIF4EBP1(1), ERBB2(4), ERBB3(10), ERBB4(9), GAB1(5), GSK3B(6), HBEGF(1), JUN(1), KRAS(4), MAP2K1(5), MAP2K2(3), MAP2K4(4), MAP2K7(2), MAPK1(3), MAPK10(4), MAPK3(1), MAPK9(4), MYC(2), NCK1(1), NCK2(2), NRAS(1), NRG1(7), NRG2(3), NRG3(7), NRG4(2), PAK1(4), PAK2(8), PAK3(6), PAK4(3), PAK6(4), PAK7(9), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PLCG1(10), PLCG2(16), PRKCA(2), PRKCG(2), PTK2(9), RAF1(2), RPS6KB1(5), RPS6KB2(3), SHC1(5), SHC2(1), SHC4(5), SOS1(10), SOS2(8), SRC(2), STAT5A(2), STAT5B(3), TGFA(1) 31228272 332 133 330 116 75 91 29 85 50 2 0.727 1.000 1.000 142 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 ACTN1(5), ACTN2(8), ACTN3(1), ACTN4(2), ARHGAP5(6), BCAR1(3), CD99(4), CDC42(2), CDH5(5), CLDN1(1), CLDN10(1), CLDN16(3), CLDN17(1), CLDN18(3), CLDN19(1), CLDN2(1), CLDN20(2), CLDN23(1), CLDN3(1), CLDN4(1), CLDN5(1), CLDN6(2), CLDN7(2), CLDN8(2), CTNNA1(1), CTNNA2(10), CTNNA3(3), CTNND1(3), CXCL12(2), CXCR4(2), CYBA(2), CYBB(4), EZR(5), F11R(1), GNAI1(4), GNAI2(2), GNAI3(1), ICAM1(2), ITGA4(7), ITGAL(7), ITGAM(7), ITGB1(3), ITGB2(9), ITK(2), JAM2(3), JAM3(3), MAPK11(4), MAPK12(2), MAPK13(1), MAPK14(4), MLLT4(7), MMP2(1), MMP9(4), MSN(6), MYL5(1), MYL9(1), MYLPF(1), NCF2(4), NCF4(1), NOX1(5), NOX3(6), OCLN(1), PECAM1(1), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PLCG1(10), PLCG2(16), PRKCA(2), PRKCG(2), PTK2(9), PTK2B(8), PTPN11(2), PXN(5), RAC1(1), RAC2(4), RAP1A(2), RAPGEF3(4), RAPGEF4(3), RASSF5(2), RHOH(1), ROCK1(7), ROCK2(8), SIPA1(1), TXK(3), VASP(3), VAV1(6), VAV2(2), VAV3(7), VCAM1(3), VCL(4) 37322835 354 133 349 125 90 99 31 81 53 0 0.838 1.000 1.000 143 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 91 ADCY1(7), ADCY2(10), ADCY3(7), ADCY4(6), ADCY5(5), ADCY6(9), ADCY7(3), ADCY8(12), ADCY9(9), AKAP1(4), AKAP11(12), AKAP12(8), AKAP3(8), AKAP4(9), AKAP5(3), AKAP6(18), AKAP7(3), AKAP8(3), AKAP9(22), ARHGEF1(3), CALM1(1), CHMP1B(1), GNA12(1), GNA13(2), GNA14(1), GNA15(2), GNAI2(2), GNAI3(1), GNAL(4), GNAO1(2), GNB1(4), GNB2(2), GNB5(6), GNG12(1), GNG5(1), GNGT1(1), IL18BP(1), ITPR1(18), KCNJ3(1), KRAS(4), NRAS(1), PALM2(1), PDE1A(2), PDE1B(3), PDE1C(11), PDE4A(9), PDE4B(3), PDE4C(2), PDE4D(8), PDE7A(5), PDE7B(1), PDE8A(8), PDE8B(3), PLCB3(5), PPP3CA(6), PPP3CC(1), PRKACA(2), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(2), PRKCD(4), PRKCG(2), PRKCH(2), PRKCI(1), PRKCQ(2), PRKCZ(3), PRKD1(7), PRKD3(2), SLC9A1(1), USP5(6) 35080652 329 131 326 147 73 84 36 92 42 2 0.998 1.000 1.000 144 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 77 ABL1(1), ACTN1(5), ACTR2(2), ACTR3(3), AKT1(2), AKT2(7), AKT3(4), ARHGEF6(4), ARHGEF7(6), BCAR1(3), BRAF(2), CAV1(1), CDC42(2), CDKN2A(3), CSE1L(4), DOCK1(14), EPHB2(7), FYN(2), GRB7(2), ILK(1), ITGA1(7), ITGA10(10), ITGA11(10), ITGA2(7), ITGA3(5), ITGA4(7), ITGA5(4), ITGA6(3), ITGA7(8), ITGA8(6), ITGA9(8), ITGB3BP(3), MAP2K4(4), MAP2K7(2), MAP3K11(3), MAPK1(3), MAPK10(4), MAPK8IP3(2), MAPK9(4), MRAS(1), MYLK(4), MYLK2(4), P4HB(1), PAK1(4), PAK2(8), PAK3(6), PAK4(3), PAK6(4), PAK7(9), PIK3CA(10), PIK3CB(12), PKLR(1), PLCG1(10), PLCG2(16), PTK2(9), RAF1(2), RALA(2), RHO(2), ROCK1(7), ROCK2(8), SHC1(5), SOS1(10), SOS2(8), SRC(2), TERF2IP(1), TLN1(12), TLN2(11), VASP(3), WAS(2), ZYX(2) 36908100 354 130 350 130 72 100 33 93 55 1 0.883 1.000 1.000 145 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(2), ACTA2(1), ACTN2(8), ACTN3(1), ACTN4(2), DES(2), DMD(33), MYBPC1(9), MYBPC2(5), MYBPC3(6), MYH3(13), MYH6(10), MYH7(16), MYH8(10), MYL1(1), MYL9(1), MYOM1(14), NEB(36), TCAP(1), TMOD1(3), TNNC2(2), TNNI1(1), TNNI2(2), TNNT2(2), TNNT3(2), TPM1(4), TPM2(5), TPM3(3), TPM4(2), TTN(182), VIM(6) 42590329 385 130 381 186 82 96 52 119 32 4 0.999 1.000 1.000 146 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(1), ADCY1(7), ADCY2(10), ADCY3(7), ADCY4(6), ADCY5(5), ADCY6(9), ADCY7(3), ADCY8(12), ADK(3), ADSL(1), ADSS(3), AK2(1), AK5(1), ALLC(5), AMPD1(7), AMPD2(4), AMPD3(4), ATIC(1), ATP1B1(2), ATP5A1(3), ATP5B(3), ATP5C1(2), ATP5D(1), ATP5F1(1), ATP5G1(1), ATP5G2(1), ATP5G3(2), ATP5H(1), ENPP1(4), ENPP3(8), ENTPD1(6), ENTPD2(2), GART(10), GDA(2), GMPS(3), GUCY1A2(5), GUCY1A3(3), GUCY1B3(7), GUCY2C(6), GUCY2D(3), GUCY2F(9), GUK1(4), HPRT1(1), IMPDH1(2), IMPDH2(3), NME1(1), NPR1(3), NPR2(6), NT5C(1), PAICS(2), PAPSS1(4), PAPSS2(5), PDE1A(2), PDE4A(9), PDE4B(3), PDE4C(2), PDE4D(8), PDE5A(5), PDE6B(7), PDE6C(5), PDE7B(1), PDE8A(8), PDE9A(3), PFAS(7), PKLR(1), POLB(4), POLD1(5), POLE(9), POLG(7), POLL(1), POLQ(18), POLR1B(3), POLR2A(10), POLR2B(8), POLR2C(1), POLR2E(2), POLR2G(2), POLR2H(1), POLR2I(2), POLRMT(1), PPAT(3), PRPS1(1), PRPS1L1(2), PRPS2(3), RRM1(5), RRM2(2) 38834317 358 129 358 170 86 96 25 107 44 0 1.000 1.000 1.000 147 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(7), ADCY8(12), ARAF(4), ATF4(6), BRAF(2), CACNA1C(8), CALM1(1), CALML6(1), CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(1), CREBBP(12), EP300(7), GRIA1(8), GRIA2(10), GRIN1(6), GRIN2A(6), GRIN2B(10), GRIN2C(4), GRIN2D(4), GRM1(8), GRM5(5), ITPR1(18), ITPR2(19), ITPR3(15), KRAS(4), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), NRAS(1), PLCB1(11), PLCB2(4), PLCB3(5), PLCB4(16), PPP1CA(3), PPP1CB(3), PPP1CC(1), PPP1R12A(8), PPP1R1A(2), PPP3CA(6), PPP3CB(5), PPP3CC(1), PPP3R1(1), PRKACA(2), PRKACB(3), PRKACG(1), PRKCA(2), PRKCG(2), PRKX(4), RAF1(2), RAP1A(2), RAPGEF3(4), RPS6KA1(4), RPS6KA2(6), RPS6KA3(10), RPS6KA6(9) 30872097 321 128 319 136 74 78 32 92 42 3 0.995 1.000 1.000 148 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 72 CALM1(1), CALML6(1), CDIPT(1), CDS1(1), CDS2(1), DGKA(5), DGKB(2), DGKD(4), DGKE(4), DGKG(6), DGKH(4), DGKI(4), DGKZ(7), FN3K(1), IMPA1(3), IMPA2(3), INPP1(3), INPP4A(2), INPP4B(4), INPP5A(6), INPP5B(5), INPP5D(3), INPP5E(1), INPPL1(3), ITPK1(2), ITPKA(1), ITPKB(2), ITPR1(18), ITPR2(19), ITPR3(15), OCRL(5), PI4KA(5), PI4KB(1), PIK3C2A(8), PIK3C2B(9), PIK3C2G(11), PIK3C3(2), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PIP4K2A(2), PIP4K2B(3), PIP4K2C(4), PIP5K1B(2), PIP5K1C(3), PLCB1(11), PLCB2(4), PLCB3(5), PLCB4(16), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(14), PLCG1(10), PLCG2(16), PLCZ1(2), PRKCA(2), PRKCG(2), SYNJ1(10), SYNJ2(2) 38065163 333 127 329 180 83 79 35 86 49 1 1.000 1.000 1.000 149 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 98 ADCY1(7), ADCY2(10), ADCY3(7), ADCY4(6), ADCY5(5), ADCY6(9), ADCY7(3), ADCY8(12), ADCY9(9), CALM1(1), CALML6(1), CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), CREB1(1), CREB3(2), CREB3L1(5), CREB3L2(2), CREB3L3(4), CREB3L4(3), CREBBP(12), DCT(5), DVL1(1), DVL2(5), EDN1(2), EDNRB(2), EP300(7), FZD1(1), FZD10(5), FZD2(3), FZD3(4), FZD4(1), FZD5(2), FZD6(4), FZD7(1), FZD8(2), FZD9(6), GNAI1(4), GNAI2(2), GNAI3(1), GNAO1(2), GNAS(9), GSK3B(6), KIT(10), KITLG(2), KRAS(4), LEF1(4), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MC1R(1), MITF(3), NRAS(1), PLCB1(11), PLCB2(4), PLCB3(5), PLCB4(16), POMC(2), PRKACA(2), PRKACB(3), PRKACG(1), PRKCA(2), PRKCG(2), PRKX(4), RAF1(2), TCF7(5), TCF7L1(5), TCF7L2(6), TYR(6), TYRP1(2), WNT1(3), WNT10B(1), WNT16(2), WNT2(3), WNT3A(1), WNT4(1), WNT5B(1), WNT6(2), WNT7A(2), WNT7B(1), WNT8A(2), WNT8B(1), WNT9B(1) 32214561 323 126 318 129 73 74 29 86 59 2 0.996 1.000 1.000 150 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVR1(4), ACVR1B(3), ACVRL1(4), AKT1(2), AURKB(2), BMPR1A(1), BMPR2(8), BUB1(6), CDIPT(1), CDKL1(1), CDKL2(4), CDS1(1), CDS2(1), CLK1(3), CLK2(2), CLK4(5), COL4A3BP(2), CSNK2A1(2), CSNK2A2(1), DGKA(5), DGKB(2), DGKD(4), DGKE(4), DGKG(6), DGKH(4), DGKZ(7), IMPA1(3), INPP1(3), INPP4A(2), INPP4B(4), INPP5A(6), INPPL1(3), ITPKA(1), ITPKB(2), MAP3K10(1), MOS(1), NEK1(9), NEK3(2), OCRL(5), PAK4(3), PIK3C2A(8), PIK3C2B(9), PIK3C2G(11), PIK3CA(10), PIK3CB(12), PIK3CG(4), PIM2(1), PLCB1(11), PLCB2(4), PLCB3(5), PLCB4(16), PLCD1(1), PLCG1(10), PLCG2(16), PLK3(3), PRKACA(2), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(2), PRKCD(4), PRKCG(2), PRKCH(2), PRKCQ(2), PRKCZ(3), PRKD1(7), PRKG1(5), RAF1(2), RPS6KA1(4), RPS6KA2(6), RPS6KA3(10), RPS6KA4(1), RPS6KB1(5), STK11(1), TGFBR1(5), VRK1(4) 34650109 327 126 324 178 66 85 41 79 55 1 1.000 1.000 1.000 151 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 93 AKT1(2), AKT2(7), AKT3(4), BCL10(1), CARD11(15), CBL(8), CBLB(4), CD247(1), CD4(3), CD8A(1), CD8B(4), CDC42(2), CHUK(9), CSF2(2), CTLA4(3), FOS(2), FYN(2), GRAP2(3), IFNG(3), IKBKB(6), IL2(1), IL4(1), ITK(2), JUN(1), KRAS(4), LCK(5), LCP2(4), MALT1(6), MAP3K14(2), MAP3K8(2), NCK1(1), NCK2(2), NFAT5(13), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), NFKB1(7), NFKB2(2), NFKBIA(2), NFKBIE(1), NRAS(1), PAK1(4), PAK2(8), PAK3(6), PAK4(3), PAK6(4), PAK7(9), PDCD1(2), PDK1(1), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PLCG1(10), PPP3CA(6), PPP3CB(5), PPP3CC(1), PPP3R1(1), PRKCQ(2), PTPN6(2), PTPRC(9), RASGRP1(9), SOS1(10), SOS2(8), TEC(2), TNF(2), VAV1(6), VAV2(2), VAV3(7), ZAP70(3) 30606686 324 124 321 124 78 75 36 90 44 1 0.907 1.000 1.000 152 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(2), AKT2(7), AKT3(4), CASP9(1), CDC42(2), KDR(13), KRAS(4), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK11(4), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(1), MAPKAPK2(4), MAPKAPK3(1), NFAT5(13), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), NOS3(8), NRAS(1), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PLA2G12A(2), PLA2G12B(2), PLA2G1B(1), PLA2G2A(1), PLA2G2D(3), PLA2G2E(1), PLA2G2F(6), PLA2G3(4), PLA2G4A(6), PLA2G6(6), PLCG1(10), PLCG2(16), PPP3CA(6), PPP3CB(5), PPP3CC(1), PPP3R1(1), PRKCA(2), PRKCG(2), PTGS2(2), PTK2(9), PXN(5), RAC1(1), RAC2(4), RAF1(2), SH2D2A(4), SHC2(1), SPHK1(6), SPHK2(4), SRC(2) 21830257 261 123 255 77 66 65 29 64 37 0 0.234 1.000 1.000 153 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(19), ABCA10(11), ABCA12(16), ABCA13(54), ABCA2(8), ABCA3(7), ABCA4(18), ABCA5(5), ABCA6(11), ABCA7(12), ABCA8(7), ABCA9(8), ABCB1(11), ABCB10(2), ABCB11(8), ABCB4(6), ABCB5(16), ABCB6(7), ABCB7(4), ABCB8(3), ABCB9(3), ABCC1(7), ABCC10(5), ABCC11(4), ABCC12(3), ABCC2(6), ABCC3(10), ABCC4(9), ABCC5(8), ABCC6(3), ABCC8(11), ABCC9(13), ABCD1(1), ABCD2(3), ABCD3(1), ABCD4(4), ABCG1(1), ABCG2(5), ABCG4(3), ABCG5(2), ABCG8(3), CFTR(12), TAP1(3), TAP2(2) 36220409 355 122 352 166 74 82 37 117 44 1 1.000 1.000 1.000 154 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 99 AKT1(2), AKT2(7), AKT3(4), CASP8(3), CCL3(1), CD40(4), CD80(1), CD86(4), CHUK(9), FADD(2), FOS(2), IFNA13(1), IFNA14(2), IFNA16(2), IFNA17(6), IFNA2(2), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(5), IFNA8(2), IFNAR1(5), IFNAR2(1), IFNB1(1), IKBKB(6), IKBKE(2), IL12A(6), IL12B(2), IL1B(2), IL6(3), IRAK1(6), IRAK4(9), IRF3(2), JUN(1), LBP(5), LY96(1), MAP2K1(5), MAP2K2(3), MAP2K4(4), MAP2K6(1), MAP2K7(2), MAP3K7(3), MAP3K8(2), MAPK1(3), MAPK10(4), MAPK11(4), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(1), MAPK9(4), MYD88(3), NFKB1(7), NFKB2(2), NFKBIA(2), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), RAC1(1), RELA(4), RIPK1(6), SPP1(1), STAT1(7), TBK1(5), TICAM1(4), TIRAP(2), TLR1(8), TLR2(2), TLR3(4), TLR4(3), TLR5(3), TLR6(6), TLR7(7), TLR8(8), TLR9(3), TNF(2), TOLLIP(1), TRAF3(1), TRAF6(1) 27006534 300 122 293 132 64 62 45 84 45 0 0.997 1.000 1.000 155 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 82 AGL(9), AMY2A(5), AMY2B(2), ASCC3(15), ATP13A2(8), DDX18(4), DDX19A(2), DDX23(4), DDX4(3), DDX41(3), DDX47(2), DDX50(4), DDX51(4), DDX52(5), DDX54(4), DDX55(4), DDX56(1), DHX58(6), ENPP1(4), ENPP3(8), ENTPD7(4), EP400(12), ERCC2(5), ERCC3(4), G6PC(4), G6PC2(4), GAA(2), GANC(3), GBA(1), GBE1(1), GCK(3), GPI(2), GUSB(6), GYS1(2), GYS2(5), HK1(4), HK2(8), HK3(6), IFIH1(5), LYZL1(3), MGAM(18), MOV10L1(2), NUDT5(1), PGM1(3), PGM3(6), PYGB(1), PYGL(8), PYGM(9), RAD54B(5), RAD54L(2), RUVBL2(1), SETX(20), SI(14), SKIV2L2(4), SMARCA2(11), SMARCA5(2), TREH(5), UGDH(4), UGP2(2), UGT1A1(1), UGT1A10(3), UGT1A3(2), UGT1A4(1), UGT1A5(13), UGT1A8(1), UGT1A9(1), UGT2A1(5), UGT2A3(3), UGT2B10(2), UGT2B11(3), UGT2B15(5), UGT2B17(1), UGT2B4(5), UGT2B7(5) 39734191 350 121 344 196 74 86 44 93 49 4 1.000 1.000 1.000 156 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 A4GNT(2), ALG1(1), ALG10B(3), ALG11(2), ALG12(1), ALG13(9), ALG2(6), ALG3(1), ALG6(5), ALG8(1), ALG9(4), B3GNT2(2), B3GNT7(1), B4GALT2(2), B4GALT3(2), B4GALT4(1), B4GALT5(2), C1GALT1C1(1), CHPF(9), CHST1(2), CHST11(1), CHST12(3), CHST13(2), CHST14(2), CHST2(4), CHST3(5), CHST4(1), CHST6(2), CHST7(1), CHSY1(2), DDOST(1), DPAGT1(3), EXT1(2), EXT2(3), EXTL1(5), EXTL2(1), EXTL3(4), FUT11(4), FUT8(2), GALNT1(4), GALNT11(3), GALNT12(3), GALNT13(7), GALNT14(3), GALNT3(3), GALNT4(7), GALNT5(6), GALNT6(4), GALNT8(6), GALNT9(3), GALNTL5(4), GANAB(5), GCNT3(4), GCNT4(2), HS2ST1(3), HS3ST1(1), HS3ST2(1), HS3ST3A1(3), HS3ST5(3), HS6ST1(1), HS6ST2(1), HS6ST3(4), MAN1A1(3), MAN1A2(4), MAN1B1(1), MAN1C1(5), MAN2A1(7), MGAT1(3), MGAT2(2), MGAT3(8), MGAT4A(2), MGAT5(5), MGAT5B(5), NDST1(3), NDST2(3), NDST3(5), NDST4(7), OGT(4), RPN1(2), RPN2(2), ST3GAL1(1), ST3GAL3(4), ST3GAL4(1), ST6GAL1(2), ST6GALNAC1(6), STT3B(3), UST(3), WBSCR17(7), XYLT1(7), XYLT2(3) 32971748 294 121 290 134 71 69 36 79 37 2 0.997 1.000 1.000 157 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 73 AKT1(2), AKT2(7), AKT3(4), BTK(1), CSF2(2), FCER1A(2), FYN(2), GAB2(3), IL3(2), IL4(1), INPP5D(3), KRAS(4), LCP2(4), LYN(3), MAP2K1(5), MAP2K2(3), MAP2K4(4), MAP2K6(1), MAP2K7(2), MAPK1(3), MAPK10(4), MAPK11(4), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(1), MAPK9(4), MS4A2(5), NRAS(1), PDK1(1), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PLA2G12A(2), PLA2G12B(2), PLA2G1B(1), PLA2G2A(1), PLA2G2D(3), PLA2G2E(1), PLA2G2F(6), PLA2G3(4), PLA2G4A(6), PLA2G6(6), PLCG1(10), PLCG2(16), PRKCA(2), PRKCD(4), RAC1(1), RAC2(4), RAF1(2), SOS1(10), SOS2(8), SYK(4), TNF(2), VAV1(6), VAV2(2), VAV3(7) 21456827 242 120 239 69 67 52 30 61 31 1 0.213 1.000 1.000 158 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 80 ABL1(1), ATM(15), BUB1(6), BUB1B(6), BUB3(2), CCNA1(2), CCNA2(2), CCNB1(4), CCNB2(2), CCNB3(8), CCND2(1), CCNE1(2), CCNE2(3), CCNH(3), CDAN1(7), CDC14A(2), CDC14B(3), CDC20(1), CDC25A(2), CDC25B(4), CDC25C(1), CDC6(1), CDC7(4), CDH1(4), CDKN1A(6), CDKN2A(3), CHEK1(7), CHEK2(6), DTX4(1), E2F1(2), E2F3(2), E2F4(2), E2F5(3), E2F6(3), EP300(7), ESPL1(7), GADD45A(1), GSK3B(6), HDAC2(5), HDAC3(2), HDAC4(5), HDAC5(3), HDAC6(8), HDAC8(1), MAD1L1(2), MAD2L1(1), MAD2L2(2), MCM2(5), MCM3(3), MCM4(4), MCM5(3), MCM6(4), MCM7(6), MDM2(2), MPEG1(5), MPL(1), PLK1(3), PRKDC(26), PTPRA(5), PTTG1(2), PTTG2(2), RBL1(6), SKP2(3), TBC1D8(7), TFDP1(3), TGFB1(1), WEE1(4) 32818409 266 118 262 93 57 54 32 77 46 0 0.614 1.000 1.000 159 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 106 ABL1(1), ANAPC1(3), ANAPC10(1), ANAPC2(4), ANAPC4(1), ANAPC5(6), ANAPC7(3), ATM(15), ATR(14), BUB1(6), BUB1B(6), BUB3(2), CCNA1(2), CCNA2(2), CCNB1(4), CCNB2(2), CCNB3(8), CCND1(1), CCND2(1), CCNE1(2), CCNE2(3), CCNH(3), CDC14A(2), CDC14B(3), CDC16(4), CDC20(1), CDC23(3), CDC25A(2), CDC25B(4), CDC25C(1), CDC6(1), CDC7(4), CDK6(2), CDK7(1), CDKN1A(6), CDKN1B(2), CDKN2A(3), CDKN2C(1), CHEK1(7), CHEK2(6), CREBBP(12), CUL1(3), DBF4(1), E2F1(2), E2F3(2), EP300(7), ESPL1(7), FZR1(4), GADD45A(1), GSK3B(6), HDAC2(5), MAD1L1(2), MAD2L1(1), MAD2L2(2), MCM2(5), MCM3(3), MCM4(4), MCM5(3), MCM6(4), MCM7(6), MDM2(2), PKMYT1(1), PLK1(3), PRKDC(26), PTTG1(2), PTTG2(2), RBL1(6), RBL2(8), SFN(1), SKP2(3), SMAD2(3), SMAD3(5), SMC1A(7), SMC1B(12), TFDP1(3), TGFB1(1), TGFB2(4), TGFB3(3), WEE1(4), YWHAB(2), YWHAE(2), YWHAG(2), YWHAH(1), YWHAZ(1) 40075926 327 117 325 140 60 79 32 98 57 1 0.990 1.000 1.000 160 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACP1(5), ACTB(1), ACTG1(1), ACTN1(5), ACTN2(8), ACTN3(1), ACTN4(2), ACVR1B(3), ACVR1C(1), BAIAP2(3), CDC42(2), CDH1(4), CREBBP(12), CSNK2A1(2), CSNK2A2(1), CTNNA1(1), CTNNA2(10), CTNNA3(3), CTNND1(3), EGFR(7), EP300(7), ERBB2(4), FARP2(7), FER(4), FGFR1(2), FYN(2), IGF1R(12), INSR(11), IQGAP1(10), LEF1(4), LMO7(11), MAP3K7(3), MAPK1(3), MAPK3(1), MET(2), MLLT4(7), NLK(3), PARD3(5), PTPN1(2), PTPN6(2), PTPRB(14), PTPRF(4), PTPRJ(4), PTPRM(16), PVRL1(2), PVRL2(4), PVRL3(3), RAC1(1), RAC2(4), SMAD2(3), SMAD3(5), SNAI1(3), SNAI2(1), SORBS1(5), SRC(2), SSX2IP(4), TCF7(5), TCF7L1(5), TCF7L2(6), TGFBR1(5), TGFBR2(1), TJP1(9), VCL(4), WAS(2), WASF1(2), WASF2(2), WASF3(4), WASL(2), YES1(4) 35841980 303 117 302 158 73 77 33 73 47 0 1.000 1.000 1.000 161 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 63 AKT1(2), AKT2(7), AKT3(4), BCL10(1), BLNK(3), BTK(1), CARD11(15), CD19(1), CD22(9), CD72(1), CD79A(1), CD81(1), CHUK(9), CR2(9), FCGR2B(3), FOS(2), GSK3B(6), IKBKB(6), INPP5D(3), JUN(1), KRAS(4), LILRB3(7), LYN(3), MALT1(6), NFAT5(13), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), NFKB1(7), NFKB2(2), NFKBIA(2), NFKBIE(1), NRAS(1), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PLCG2(16), PPP3CA(6), PPP3CB(5), PPP3CC(1), PPP3R1(1), PTPN6(2), RAC1(1), RAC2(4), RASGRP3(4), SYK(4), VAV1(6), VAV2(2), VAV3(7) 22503896 253 117 250 91 65 52 38 66 32 0 0.683 1.000 1.000 162 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR1(4), ACVR1B(3), ACVR1C(1), ACVR2A(11), ACVR2B(4), ACVRL1(4), AMH(1), AMHR2(1), BMP2(3), BMP4(1), BMP5(3), BMP7(3), BMPR1A(1), BMPR1B(2), BMPR2(8), CHRD(2), COMP(2), CREBBP(12), CUL1(3), DCN(2), E2F4(2), E2F5(3), EP300(7), FST(3), GDF5(4), ID1(1), IFNG(3), INHBA(2), INHBC(3), INHBE(1), LEFTY1(2), LEFTY2(1), LTBP1(9), MAPK1(3), MAPK3(1), MYC(2), NOG(1), PITX2(1), PPP2CA(4), PPP2CB(3), PPP2R1A(4), PPP2R1B(3), PPP2R2B(3), PPP2R2C(4), RBL1(6), RBL2(8), ROCK1(7), ROCK2(8), RPS6KB1(5), RPS6KB2(3), SMAD1(1), SMAD2(3), SMAD3(5), SMAD5(2), SMAD6(1), SMAD7(3), SMAD9(4), SMURF1(4), SMURF2(3), SP1(2), TFDP1(3), TGFB1(1), TGFB2(4), TGFB3(3), TGFBR1(5), TGFBR2(1), THBS1(3), THBS2(5), THBS3(5), THBS4(3), TNF(2), ZFYVE16(10), ZFYVE9(10) 29623889 261 116 260 123 54 66 33 63 42 3 0.999 1.000 1.000 163 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 85 ATF2(1), BRAF(2), CHUK(9), CREB1(1), DAXX(1), FOS(2), IKBKB(6), JUN(1), MAP2K1(5), MAP2K2(3), MAP2K4(4), MAP2K5(1), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K10(1), MAP3K11(3), MAP3K12(2), MAP3K13(3), MAP3K14(2), MAP3K2(1), MAP3K3(2), MAP3K4(9), MAP3K5(6), MAP3K6(8), MAP3K7(3), MAP3K8(2), MAP3K9(5), MAP4K1(5), MAP4K2(4), MAP4K3(6), MAP4K4(9), MAP4K5(11), MAPK1(3), MAPK10(4), MAPK11(4), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(1), MAPK4(5), MAPK6(7), MAPK7(6), MAPK9(4), MAPKAPK2(4), MAPKAPK3(1), MAPKAPK5(4), MEF2A(4), MEF2C(3), MEF2D(1), MKNK1(2), MKNK2(1), MYC(2), NFKB1(7), NFKBIA(2), PAK1(4), PAK2(8), RAC1(1), RAF1(2), RELA(4), RIPK1(6), RPS6KA1(4), RPS6KA2(6), RPS6KA3(10), RPS6KA4(1), RPS6KA5(3), RPS6KB1(5), RPS6KB2(3), SHC1(5), SP1(2), STAT1(7), TGFB1(1), TGFB2(4), TGFB3(3), TGFBR1(5) 29705913 283 116 278 120 65 67 34 68 48 1 0.984 1.000 1.000 164 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 81 AKT1(2), AKT2(7), AKT3(4), APAF1(10), ATM(15), BAX(1), BCL2(1), BID(2), BIRC2(6), BIRC3(6), CAPN1(3), CAPN2(1), CASP10(4), CASP3(2), CASP6(2), CASP7(4), CASP8(3), CASP9(1), CFLAR(2), CHUK(9), CSF2RB(3), DFFA(2), DFFB(3), ENDOG(2), FADD(2), FAS(5), FASLG(2), IKBKB(6), IL1A(3), IL1B(2), IL1R1(4), IL1RAP(4), IL3(2), IRAK1(6), IRAK2(3), IRAK3(4), IRAK4(9), MAP3K14(2), MYD88(3), NFKB1(7), NFKB2(2), NFKBIA(2), NTRK1(5), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PPP3CA(6), PPP3CB(5), PPP3CC(1), PPP3R1(1), PRKACA(2), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), RELA(4), RIPK1(6), TNF(2), TNFRSF10A(4), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(5), TNFRSF1A(2), TNFSF10(2) 25169638 267 115 264 87 58 62 28 75 43 1 0.489 1.000 1.000 165 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 71 ACACB(14), ACSL1(3), ACSL3(3), ACSL4(2), ACSL5(3), ACSL6(2), ADIPOR1(4), ADIPOR2(2), AKT1(2), AKT2(7), AKT3(4), CAMKK1(3), CAMKK2(3), CD36(1), CHUK(9), CPT1A(6), CPT1B(4), CPT1C(3), CPT2(1), G6PC(4), G6PC2(4), IKBKB(6), IRS1(4), IRS2(2), IRS4(9), JAK1(8), JAK2(9), JAK3(5), LEP(1), LEPR(7), MAPK10(4), MAPK9(4), NFKB1(7), NFKB2(2), NFKBIA(2), NFKBIE(1), PCK1(6), POMC(2), PPARA(4), PPARGC1A(4), PRKAA1(4), PRKAA2(4), PRKAB1(1), PRKAB2(1), PRKAG2(3), PRKAG3(2), PRKCQ(2), PTPN11(2), RELA(4), RXRA(6), RXRB(5), RXRG(2), SLC2A4(1), STAT3(5), STK11(1), TNF(2), TNFRSF1A(2), TNFRSF1B(3), TYK2(7) 25127757 228 115 228 115 48 55 24 72 29 0 1.000 1.000 1.000 166 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(2), AKT2(7), AKT3(4), BCL2(1), BCR(4), BLNK(3), BTK(1), CD19(1), CD22(9), CD81(1), CR2(9), CSK(2), FLOT1(6), FLOT2(1), GSK3A(2), GSK3B(6), INPP5D(3), ITPR1(18), ITPR2(19), ITPR3(15), LYN(3), MAP4K1(5), MAPK1(3), MAPK3(1), NFATC1(3), NFATC2(4), NR0B2(3), PDK1(1), PIK3CA(10), PIK3CD(5), PIK3R1(5), PLCG2(16), PPP1R13B(7), PPP3CA(6), PPP3CB(5), PPP3CC(1), PTPRC(9), RAF1(2), SHC1(5), SOS1(10), SOS2(8), SYK(4), VAV1(6) 22089323 236 115 234 76 60 49 30 72 23 2 0.408 1.000 1.000 167 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 91 ACTB(1), BCL2(1), CABIN1(8), CALM1(1), CAMK2B(2), CAMK4(1), CD69(2), CDKN1A(6), CNR1(3), CREBBP(12), CSF2(2), CSNK2A1(2), CTLA4(3), EGR2(3), EGR3(5), EP300(7), FCER1A(2), FCGR3A(1), FOS(2), FOSL1(1), GATA3(1), GATA4(1), GSK3A(2), GSK3B(6), IFNB1(1), IFNG(3), IL1B(2), IL2(1), IL2RA(2), IL3(2), IL4(1), IL6(3), ITK(2), JUNB(2), KPNA5(2), MAP2K7(2), MAPK14(4), MAPK9(4), MEF2A(4), MEF2D(1), MYF5(1), NCK2(2), NFAT5(13), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), NFKB2(2), NFKBIE(1), NPPB(1), NUP214(9), P2RX7(3), PAK1(4), PIN1(1), PPIA(2), PPP3CB(5), PPP3CC(1), PPP3R1(1), PTPRC(9), RELA(4), SFN(1), SP1(2), SP3(3), TGFB1(1), TNF(2), TRPV6(6), VAV1(6), VAV2(2), VAV3(7), XPO5(8) 27302922 224 109 222 106 40 64 24 65 30 1 0.998 1.000 1.000 168 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(9), BDKRB1(2), BDKRB2(4), C1QA(2), C1QC(1), C1R(1), C1S(4), C2(9), C3(12), C3AR1(2), C4A(2), C4BPA(1), C5(9), C5AR1(1), C6(2), C7(3), C8A(3), C8B(7), C9(3), CD46(3), CD55(4), CD59(1), CFB(2), CFH(14), CFI(3), CPB2(3), CR2(9), F10(3), F13A1(4), F13B(2), F2(2), F2R(2), F3(2), F5(18), F8(11), F9(1), FGA(9), FGB(2), FGG(4), KLKB1(7), KNG1(5), MASP1(4), MASP2(4), MBL2(1), PLAT(2), PLAU(6), PLAUR(2), PLG(1), PROC(5), PROS1(4), SERPINA1(4), SERPINA5(3), SERPINC1(4), SERPIND1(2), SERPINE1(4), SERPINF2(1), SERPING1(1), TFPI(4), THBD(2), VWF(10) 30341643 252 109 247 128 48 63 39 68 34 0 0.999 1.000 1.000 169 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 51 ACTG1(1), APAF1(10), ARHGDIB(1), BAG4(5), BCL2(1), BID(2), BIRC2(6), BIRC3(6), CASP2(1), CASP3(2), CASP6(2), CASP7(4), CASP8(3), CASP9(1), CFLAR(2), CHUK(9), CRADD(1), DAXX(1), DFFA(2), DFFB(3), FADD(2), GSN(2), LMNA(3), LMNB1(5), LMNB2(4), MAP2K7(2), MAP3K1(6), MAP3K14(2), MAP3K5(6), MDM2(2), NFKB1(7), NFKBIA(2), NUMA1(9), PAK2(8), PRKCD(4), PRKDC(26), PSEN1(2), PTK2(9), RASA1(10), RELA(4), RIPK1(6), SPTAN1(9), TNF(2), TNFRSF1A(2), TNFRSF1B(3), TRAF1(3) 20625325 203 105 201 82 37 47 16 61 42 0 0.968 1.000 1.000 170 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(5), CD19(1), CD1A(1), CD1B(1), CD1C(1), CD1D(3), CD1E(4), CD2(2), CD22(9), CD33(3), CD36(1), CD37(2), CD38(2), CD4(3), CD44(3), CD5(6), CD55(4), CD59(1), CD8A(1), CD8B(4), CD9(1), CR2(9), CSF1(1), CSF1R(3), CSF2(2), CSF2RA(4), CSF3R(1), DNTT(4), FCER2(2), FCGR1A(2), FLT3(10), FLT3LG(2), GP5(1), GYPA(2), HLA-DRB1(4), HLA-DRB5(3), IL11RA(1), IL1A(3), IL1B(2), IL1R1(4), IL1R2(2), IL2RA(2), IL3(2), IL4(1), IL4R(4), IL5RA(2), IL6(3), IL6R(1), IL7(2), IL7R(10), IL9R(5), ITGA1(7), ITGA2(7), ITGA2B(5), ITGA3(5), ITGA4(7), ITGA5(4), ITGA6(3), ITGAM(7), ITGB3(3), KIT(10), KITLG(2), MME(8), MS4A1(4), TFRC(1), THPO(1), TNF(2), TPO(11) 23844589 239 105 235 117 58 49 31 63 38 0 0.999 1.000 1.000 171 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(1), CDC40(3), CLK2(2), CLK3(3), CLK4(5), COL2A1(5), CPSF1(6), CPSF2(3), CPSF3(4), CPSF4(1), CSTF1(1), CSTF2(4), CSTF2T(1), CSTF3(3), DDIT3(1), DDX1(1), DDX20(8), DHX15(3), DHX16(7), DHX38(4), DHX8(3), DHX9(11), DICER1(13), DNAJC8(1), FUS(3), GIPC1(1), LOC440563(3), LSM7(1), METTL3(1), NCBP1(5), NONO(2), NUDT21(1), NXF1(3), PABPN1(1), PAPOLA(3), POLR2A(10), PPM1G(2), PRPF3(1), PRPF4(4), PRPF4B(4), PRPF8(12), PSKH1(2), PTBP1(4), PTBP2(4), RBM17(1), RBM5(5), RNGTT(4), RNMT(1), RNPS1(2), SF3A1(5), SF3A2(1), SF3A3(4), SF3B1(8), SF3B2(3), SF3B4(2), SNRPA(1), SNRPA1(3), SNRPB(1), SNRPB2(2), SNRPD3(1), SNRPF(1), SNRPN(2), SPOP(5), SRPK1(4), SRPK2(1), SRRM1(3), SUPT5H(5), TXNL4A(1), U2AF1(1), U2AF2(3), XRN2(4) 32006408 235 104 235 102 46 58 20 66 44 1 0.994 1.000 1.000 172 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 62 AKT1(2), AKT2(7), AKT3(4), CDC42(2), CDKN1B(2), CDKN2A(3), CREB1(1), CREB3(2), CREB5(5), ERBB4(9), GAB1(5), GADD45A(1), GSK3A(2), GSK3B(6), IFI27(1), IGF1(1), INPPL1(3), IRS1(4), IRS2(2), IRS4(9), MET(2), MYC(2), NOLC1(5), PAK1(4), PAK2(8), PAK3(6), PAK4(3), PAK6(4), PAK7(9), PARD3(5), PDK1(1), PIK3CA(10), PIK3CD(5), PPP1R13B(7), PREX1(14), PTK2(9), PTPN1(2), RPS6KA1(4), RPS6KA2(6), RPS6KA3(10), RPS6KB1(5), SFN(1), SHC1(5), SLC2A4(1), SOS1(10), SOS2(8), TSC1(13), TSC2(15), YWHAB(2), YWHAE(2), YWHAG(2), YWHAH(1), YWHAZ(1) 22602208 253 104 251 92 47 69 32 69 35 1 0.640 1.000 1.000 173 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 32 AKT1(2), AKT2(7), AKT3(4), BCR(4), BTK(1), CD19(1), CDKN2A(3), DAPP1(1), FLOT1(6), FLOT2(1), GAB1(5), ITPR1(18), ITPR2(19), ITPR3(15), LYN(3), NR0B2(3), PDK1(1), PHF11(1), PIK3CA(10), PITX2(1), PLCG2(16), PPP1R13B(7), PREX1(14), PTPRC(9), RPS6KA1(4), RPS6KA2(6), RPS6KA3(10), RPS6KB1(5), SAG(1), SYK(4), TEC(2), VAV1(6) 16442653 190 103 188 64 48 44 22 56 19 1 0.560 1.000 1.000 174 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(6), ADCY6(9), ADCY8(12), CACNA1A(7), CACNA1B(15), GNAS(9), GNAT3(4), GNB1(4), GRM4(4), ITPR3(15), PDE1A(2), PLCB2(4), PRKACA(2), PRKACB(3), PRKACG(1), PRKX(4), SCNN1A(4), SCNN1G(6), TAS1R1(4), TAS1R2(4), TAS1R3(6), TAS2R1(2), TAS2R10(2), TAS2R13(2), TAS2R14(1), TAS2R16(3), TAS2R3(2), TAS2R38(1), TAS2R39(2), TAS2R4(1), TAS2R40(1), TAS2R41(2), TAS2R42(4), TAS2R43(10), TAS2R46(6), TAS2R50(2), TAS2R60(1), TAS2R7(5), TAS2R8(3), TAS2R9(1), TRPM5(4) 17492506 180 102 177 72 39 46 18 57 18 2 0.983 1.000 1.000 175 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 46 FN3K(1), IMPA1(3), IMPA2(3), INPP1(3), INPP4A(2), INPP4B(4), INPP5A(6), INPP5B(5), INPP5E(1), INPPL1(3), ITPK1(2), ITPKA(1), ITPKB(2), MINPP1(1), OCRL(5), PI4KA(5), PI4KB(1), PIK3C3(2), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIP4K2A(2), PIP4K2B(3), PIP4K2C(4), PIP5K1B(2), PIP5K1C(3), PLCB1(11), PLCB2(4), PLCB3(5), PLCB4(16), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(14), PLCG1(10), PLCG2(16), PLCZ1(2), SYNJ1(10), SYNJ2(2) 22269336 190 100 188 111 44 51 23 44 28 0 1.000 1.000 1.000 176 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(2), AKT2(7), AKT3(4), BRAF(2), CAB39(3), EIF4B(3), EIF4EBP1(1), FIGF(1), HIF1A(3), IGF1(1), MAPK1(3), MAPK3(1), PDPK1(2), PIK3CA(10), PIK3CB(12), PIK3CD(5), PIK3CG(4), PIK3R1(5), PIK3R2(4), PIK3R3(4), PIK3R5(3), PRKAA1(4), PRKAA2(4), RICTOR(9), RPS6(1), RPS6KA1(4), RPS6KA2(6), RPS6KA3(10), RPS6KA6(9), RPS6KB1(5), RPS6KB2(3), STK11(1), TSC1(13), TSC2(15), ULK1(8), ULK2(8), VEGFB(2), VEGFC(5) 16254507 187 100 184 41 43 51 18 37 36 2 0.00677 1.000 1.000 177 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 66 ADAM10(2), ADAM17(9), ATP6AP1(2), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(1), ATP6V0D2(3), ATP6V1A(3), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(3), ATP6V1D(2), ATP6V1E2(1), ATP6V1F(2), ATP6V1G3(1), ATP6V1H(2), CASP3(2), CDC42(2), CHUK(9), CSK(2), CXCL1(1), EGFR(7), F11R(1), GIT1(2), HBEGF(1), IGSF5(7), IKBKB(6), JAM2(3), JAM3(3), JUN(1), LYN(3), MAP2K4(4), MAP3K14(2), MAPK10(4), MAPK11(4), MAPK12(2), MAPK13(1), MAPK14(4), MAPK9(4), MET(2), NFKB1(7), NFKB2(2), NFKBIA(2), NOD1(2), PAK1(4), PLCG1(10), PLCG2(16), PTPN11(2), PTPRZ1(13), RAC1(1), RELA(4), SRC(2), TJP1(9) 21492559 204 99 203 82 48 46 20 56 34 0 0.961 1.000 1.000 178 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(3), ALG6(5), CCKBR(4), CCR2(4), CCR3(3), CCR5(2), CELSR1(22), CELSR2(10), CELSR3(14), CHRM2(5), CHRM3(4), CIDEB(2), CXCR3(1), EDNRA(3), EMR2(3), EMR3(4), F2R(2), FSHR(2), GHRHR(2), GNRHR(2), GPR116(9), GPR132(4), GPR133(6), GPR135(2), GPR143(1), GPR17(3), GPR18(3), GPR55(3), GPR56(2), GPR61(1), GPR84(6), GRM1(8), HRH4(3), LGR6(4), LPHN2(9), LPHN3(12), OR8G2(1), P2RY13(2), PTGFR(3), SSTR2(2), TAAR5(2), TSHR(4), VN1R1(3) 19842815 190 98 188 93 42 48 21 59 20 0 0.999 1.000 1.000 179 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(2), CAD(7), CDA(2), CTPS2(3), DCTD(1), DHODH(4), DPYD(17), DUT(2), ENTPD1(6), ENTPD3(1), ENTPD4(2), ENTPD5(4), ENTPD6(4), NME1(1), NME4(1), NME6(1), NT5C(1), NT5C1A(2), NT5C1B(2), NT5C2(6), PNPT1(4), POLA1(10), POLA2(1), POLD1(5), POLD3(1), POLE(9), POLE2(7), POLE3(2), POLR1A(10), POLR1B(3), POLR1C(1), POLR1D(1), POLR2A(10), POLR2B(8), POLR2C(1), POLR2E(2), POLR2G(2), POLR2H(1), POLR2I(2), POLR3A(9), POLR3B(4), POLR3K(1), PRIM1(2), PRIM2(2), RFC5(3), RRM1(5), RRM2(2), TK1(2), TK2(3), TXNRD1(1), TXNRD2(2), UCK2(3), UMPS(2), UPB1(1), UPP1(1), UPP2(2), UPRT(2), ZNRD1(1) 24644269 197 97 194 108 51 53 18 50 23 2 1.000 1.000 1.000 180 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 63 APAF1(10), ATM(15), ATR(14), BAI1(5), BAX(1), BID(2), CASP3(2), CASP8(3), CASP9(1), CCNB1(4), CCNB2(2), CCNB3(8), CCND1(1), CCND2(1), CCNE1(2), CCNE2(3), CCNG1(1), CCNG2(1), CD82(2), CDK6(2), CDKN1A(6), CDKN2A(3), CHEK1(7), CHEK2(6), DDB2(4), EI24(7), FAS(5), GADD45A(1), GTSE1(4), IGF1(1), IGFBP3(1), MDM2(2), MDM4(4), PERP(2), RCHY1(1), RFWD2(2), RPRM(1), RRM2(2), SERPINB5(2), SERPINE1(4), SESN1(6), SESN2(5), SESN3(4), SFN(1), SIAH1(6), STEAP3(2), THBS1(3), TNFRSF10B(2), TP73(1), TSC2(15), ZMAT3(2) 19224753 192 96 192 67 44 34 19 63 31 1 0.728 1.000 1.000 181 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 62 ATM(15), CCNA1(2), CCNB1(4), CCND1(1), CCND2(1), CCNE1(2), CCNE2(3), CCNG2(1), CCNH(3), CDC25A(2), CDK7(1), CDKN1A(6), CDKN1B(2), CDKN2A(3), CDKN2C(1), CREB3(2), CREB3L1(5), CREB3L3(4), CREB3L4(3), E2F1(2), E2F3(2), E2F4(2), E2F5(3), E2F6(3), GADD45A(1), MCM2(5), MCM3(3), MCM4(4), MCM5(3), MCM6(4), MCM7(6), MDM2(2), MNAT1(1), MYC(2), MYT1(6), NACA(6), POLA2(1), POLE(9), POLE2(7), PRIM1(2), RBL1(6), RPA1(5), RPA2(2), RPA3(1), TFDP1(3), TFDP2(5), TNXB(23), WEE1(4) 22500122 184 95 183 71 37 44 19 61 22 1 0.771 1.000 1.000 182 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(2), ACADL(6), ACADM(1), ACOX1(6), ACOX2(4), ACOX3(7), ACSL1(3), ACSL3(3), ACSL4(2), ACSL5(3), ACSL6(2), ANGPTL4(1), APOA2(1), APOA5(1), APOC3(1), AQP7(11), CD36(1), CPT1A(6), CPT1B(4), CPT1C(3), CPT2(1), CYP27A1(4), CYP4A11(5), CYP4A22(4), CYP7A1(3), CYP8B1(3), DBI(1), EHHADH(14), FABP1(1), FABP2(1), FABP4(1), FADS2(1), GK(3), GK2(3), HMGCS2(3), ILK(1), LPL(4), ME1(1), MMP1(3), NR1H3(3), OLR1(1), PCK1(6), PDPK1(2), PLTP(3), PPARA(4), PPARD(1), PPARG(1), RXRA(6), RXRB(5), RXRG(2), SCD(2), SCP2(2), SLC27A2(1), SLC27A4(1), SLC27A5(7), SLC27A6(3), SORBS1(5), UBC(4), UCP1(3) 19694085 187 95 180 72 29 38 30 65 25 0 0.824 1.000 1.000 183 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(9), CREBBP(12), CTBP1(2), CTBP2(5), DLL1(2), DLL3(6), DLL4(2), DTX2(5), DTX3(4), DTX3L(8), DTX4(1), DVL1(1), DVL2(5), EP300(7), HDAC2(5), HES1(4), JAG1(6), JAG2(6), LFNG(5), MAML1(1), MAML2(2), MAML3(2), MFNG(2), NCOR2(11), NCSTN(4), NOTCH1(6), NOTCH2(13), NOTCH3(16), NOTCH4(13), NUMB(2), NUMBL(3), PSEN1(2), PSENEN(1), RBPJ(2), RBPJL(1), SNW1(2) 21438483 178 95 177 104 50 31 20 55 22 0 1.000 1.000 1.000 184 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 48 AKT1(2), AKT2(7), AKT3(4), BRD4(5), CBL(8), CDC42(2), CDKN2A(3), FLOT1(6), FLOT2(1), GSK3A(2), GSK3B(6), INPPL1(3), IRS1(4), IRS2(2), IRS4(9), LNPEP(10), MAPK1(3), MAPK3(1), PARD3(5), PDK1(1), PIK3CA(10), PIK3CD(5), PIK3R1(5), PPYR1(2), PTPN1(2), RAF1(2), RPS6KA1(4), RPS6KA2(6), RPS6KA3(10), RPS6KB1(5), SERPINB6(5), SFN(1), SHC1(5), SLC2A4(1), SORBS1(5), SOS1(10), SOS2(8), YWHAB(2), YWHAE(2), YWHAG(2), YWHAH(1), YWHAZ(1) 17266432 178 95 177 56 37 50 24 45 20 2 0.221 1.000 1.000 185 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(2), CPEB1(2), EGFR(7), ERBB2(4), ERBB4(9), ETS1(1), ETS2(2), ETV6(2), ETV7(1), FMN2(9), KRAS(4), MAP2K1(5), MAPK1(3), MAPK3(1), NOTCH1(6), NOTCH2(13), NOTCH3(16), NOTCH4(13), PIWIL1(5), PIWIL2(6), PIWIL3(7), PIWIL4(18), RAF1(2), SOS1(10), SOS2(8), SPIRE1(9), SPIRE2(2) 15845781 167 94 164 83 46 35 17 51 17 1 0.997 1.000 1.000 186 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 43 ACTR2(2), ACTR3(3), AKT1(2), AKT2(7), AKT3(4), ARHGAP1(1), ARHGAP4(1), ARHGEF11(5), BTK(1), CDC42(2), CFL1(3), CFL2(2), GDI1(2), GDI2(1), INPPL1(3), ITPR1(18), ITPR2(19), ITPR3(15), LIMK1(2), MYLK(4), MYLK2(4), PAK1(4), PAK2(8), PAK3(6), PAK4(3), PAK6(4), PAK7(9), PDK1(1), PIK3CA(10), PIK3CD(5), PIK3CG(4), PIK3R1(5), PITX2(1), PPP1R13B(7), RACGAP1(5), RHO(2), ROCK1(7), ROCK2(8), SAG(1), WASF1(2), WASL(2) 21095990 195 94 193 84 41 50 19 53 31 1 0.983 1.000 1.000 187 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(2), AKT2(7), AKT3(4), ASAH1(4), BRAF(2), DRD2(2), EGFR(7), EPHB2(7), ITPKA(1), ITPKB(2), ITPR1(18), ITPR2(19), ITPR3(15), KCNJ3(1), KCNJ5(1), MAPK1(3), PI3(2), PIK3CB(12), PITX2(1), PLCB1(11), PLCB2(4), PLCB3(5), PLCB4(16), RAF1(2), RGS20(2), SHC1(5), SOS1(10), SOS2(8), SRC(2), STAT3(5), TERF2IP(1) 17667378 181 94 179 77 45 50 12 53 19 2 0.981 1.000 1.000 188 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(4), ADH1A(2), ADH1B(6), ADH5(1), ADH6(2), ADH7(3), ADHFE1(1), ALDH1A3(2), ALDH3A1(3), ALDH3B1(5), ALDH3B2(4), AOC2(3), AOC3(3), AOX1(10), CARM1(2), COMT(1), DBH(2), DCT(5), DDC(4), ECH1(3), ESCO1(4), ESCO2(5), FAH(1), GOT1(2), GOT2(2), GSTZ1(2), HEMK1(5), HGD(2), HPD(3), LCMT1(2), LCMT2(4), MAOA(4), MAOB(3), METTL2B(6), METTL6(1), NAT6(2), PNPLA3(3), PRMT3(2), PRMT5(4), PRMT6(4), PRMT7(1), PRMT8(3), SH3GLB1(2), TAT(1), TH(3), TPO(11), TYR(6), TYRP1(2), WBSCR22(1) 17718346 157 93 155 73 37 32 18 45 22 3 0.983 1.000 1.000 189 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 ALG2(6), BAX(1), BFAR(1), BTK(1), CAD(7), CASP10(4), CASP3(2), CASP8(3), CASP8AP2(6), CSNK1A1(1), DAXX(1), DEDD2(4), DFFA(2), DIABLO(3), EGFR(7), EPHB2(7), FADD(2), FAF1(6), FAIM2(1), IL1A(3), MAP2K4(4), MAP2K7(2), MAP3K1(6), MAP3K5(6), MAPK1(3), MAPK10(4), MAPK8IP3(2), MAPK9(4), MET(2), NFAT5(13), NFKB1(7), NFKB2(2), NFKBIA(2), NFKBIE(1), NFKBIL1(3), NR0B2(3), PTPN13(21), RALBP1(1), RIPK1(6), ROCK1(7), SMPD1(3), TNFRSF6B(2), TPX2(4) 22202888 176 93 175 71 39 42 18 51 26 0 0.925 1.000 1.000 190 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(10), BAX(1), BCL2(1), BCL2L11(1), BID(2), BIRC2(6), BIRC3(6), CASP1(4), CASP10(4), CASP2(1), CASP3(2), CASP4(4), CASP6(2), CASP7(4), CASP8(3), CASP9(1), CHUK(9), DFFA(2), DFFB(3), FADD(2), FAS(5), FASLG(2), GZMB(1), HELLS(10), IKBKB(6), IRF1(1), IRF2(3), IRF3(2), IRF4(4), IRF6(4), JUN(1), LTA(2), MAP2K4(4), MAP3K1(6), MAPK10(4), MDM2(2), MYC(2), NFKB1(7), NFKBIA(2), NFKBIE(1), PLEKHG5(4), PRF1(4), RELA(4), RIPK1(6), TNF(2), TNFRSF10B(2), TNFRSF1A(2), TNFRSF1B(3), TNFRSF21(6), TNFRSF25(3), TNFSF10(2), TP73(1), TRAF1(3), TRAF3(1) 17226290 180 92 180 73 41 37 19 51 32 0 0.960 1.000 1.000 191 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(3), ATP8A1(8), AVPR1B(2), BDKRB1(2), BDKRB2(4), BRS3(2), C3AR1(2), CCKBR(4), CCR1(3), CCR2(4), CCR3(3), CCR5(2), CCR6(4), CCR7(4), CCR8(1), CX3CR1(4), CXCR3(1), CXCR4(2), CXCR6(2), EDNRA(3), EDNRB(2), FPR1(2), FSHR(2), GALR1(2), GALT(1), GHSR(2), GNB2L1(2), GNRHR(2), LHCGR(7), MC1R(1), MC2R(4), MC3R(2), MC4R(2), MC5R(5), NMBR(3), NPY1R(4), NPY2R(4), NPY5R(4), OPRK1(2), OPRL1(1), OPRM1(10), OXTR(2), PPYR1(2), SSTR2(2), SSTR3(6), SSTR4(2), TAC4(2), TACR1(5), TACR2(6), TACR3(4), TRHR(5), TSHR(4) 15263756 164 90 162 81 37 29 16 62 20 0 0.999 1.000 1.000 192 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 ACOX1(6), APOA2(1), CD36(1), CITED2(1), CPT1B(4), CREBBP(12), DUSP1(1), DUT(2), EHHADH(14), EP300(7), FABP1(1), HSD17B4(8), JUN(1), LPL(4), MAPK1(3), MAPK3(1), ME1(1), MRPL11(1), MYC(2), NCOA1(6), NCOR1(11), NCOR2(11), NFKBIA(2), NR0B2(3), NR1H3(3), NRIP1(4), PDGFA(2), PIK3CA(10), PIK3R1(5), PPARA(4), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(2), PTGS2(2), RELA(4), RXRA(6), SP1(2), SRA1(2), STAT5A(2), STAT5B(3), TNF(2) 18696017 166 90 165 74 34 43 18 44 25 2 0.991 1.000 1.000 193 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(3), BMP4(1), BMP5(3), BMP7(3), BTRC(6), CSNK1A1(1), CSNK1A1L(4), CSNK1E(3), CSNK1G1(4), CSNK1G3(1), FBXW11(8), GLI1(7), GLI2(11), GLI3(13), GSK3B(6), HHIP(7), LRP2(27), PRKACA(2), PRKACB(3), PRKACG(1), PRKX(4), PTCH1(3), PTCH2(8), RAB23(2), SHH(2), STK36(11), SUFU(4), WNT1(3), WNT10B(1), WNT16(2), WNT2(3), WNT3A(1), WNT4(1), WNT5B(1), WNT6(2), WNT7A(2), WNT7B(1), WNT8A(2), WNT8B(1), WNT9B(1) 17848394 169 89 168 73 40 36 19 53 18 3 0.987 1.000 1.000 194 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(2), AKT2(7), AKT3(4), BCR(4), BLNK(3), BTK(1), CD19(1), CSK(2), EPHB2(7), ITPKA(1), ITPKB(2), LYN(3), MAP2K1(5), MAP2K2(3), MAPK1(3), NFAT5(13), NFKB1(7), NFKB2(2), NFKBIA(2), NFKBIE(1), NFKBIL1(3), PI3(2), PIK3CA(10), PIK3CD(5), PIK3R1(5), PLCG2(16), PPP1R13B(7), RAF1(2), SERPINA4(3), SHC1(5), SOS1(10), SOS2(8), SYK(4), VAV1(6) 15856107 159 89 158 60 42 36 25 40 15 1 0.751 1.000 1.000 195 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(3), INPP1(3), INPP4A(2), INPP4B(4), INPP5A(6), INPPL1(3), ITPKA(1), ITPKB(2), OCRL(5), PIK3C2A(8), PIK3C2B(9), PIK3C2G(11), PIK3CA(10), PIK3CB(12), PIK3CG(4), PLCB1(11), PLCB2(4), PLCB3(5), PLCB4(16), PLCD1(1), PLCG1(10), PLCG2(16) 13669738 146 88 144 77 34 38 17 31 26 0 1.000 1.000 1.000 196 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(2), AKT1(2), BDKRB2(4), CALM1(1), CAV1(1), CHRNA1(3), FLT1(11), FLT4(9), KDR(13), NOS3(8), PDE2A(6), PDE3A(7), PDE3B(9), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKG1(5), PRKG2(11), RYR2(47), SYT1(1), TNNI1(1) 12690420 150 88 147 53 29 35 16 49 19 2 0.774 1.000 1.000 197 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 44 AGL(9), AMY2A(5), AMY2B(2), ENPP1(4), ENPP3(8), G6PC(4), GAA(2), GANAB(5), GBE1(1), GCK(3), GPI(2), GUSB(6), GYS1(2), GYS2(5), HK1(4), HK2(8), HK3(6), MGAM(18), PGM1(3), PGM3(6), PYGB(1), PYGL(8), PYGM(9), RNPC3(1), SI(14), UCHL1(1), UCHL3(1), UGDH(4), UGT1A1(1), UGT1A10(3), UGT1A3(2), UGT1A4(1), UGT1A5(13), UGT1A8(1), UGT1A9(1), UGT2B15(5), UGT2B4(5) 20222499 174 86 171 91 35 39 28 46 24 2 0.999 1.000 1.000 198 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(2), AANAT(2), ABP1(4), ACAT1(1), ACAT2(6), ACMSD(2), AFMID(3), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH7A1(2), ALDH9A1(2), AOC2(3), AOC3(3), AOX1(10), ASMT(1), CARM1(2), CAT(1), CYP1A1(4), CYP1B1(2), DDC(4), ECHS1(2), EHHADH(14), GCDH(2), HAAO(1), HADH(1), HADHA(3), HEMK1(5), HSD17B4(8), KMO(3), KYNU(4), LCMT1(2), LCMT2(4), LNX1(2), MAOA(4), MAOB(3), METTL2B(6), METTL6(1), NFX1(7), OGDH(4), OGDHL(2), PRMT3(2), PRMT5(4), PRMT6(4), PRMT7(1), PRMT8(3), TDO2(5), TPH1(3), TPH2(4), WARS(6), WARS2(1), WBSCR22(1) 18105712 176 85 175 78 41 41 20 55 17 2 0.962 1.000 1.000 199 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(2), APC(12), AR(12), ASAH1(4), BRAF(2), CAMP(1), CCL13(1), CCL15(4), CCL16(1), EGFR(7), GNA15(2), GNAI1(4), ITPKA(1), ITPKB(2), ITPR1(18), ITPR2(19), ITPR3(15), KCNJ3(1), KCNJ5(1), MAPK1(3), MAPK10(4), MAPK14(4), PHKA2(5), PIK3CA(10), PIK3CD(5), PIK3R1(5), PITX2(1), PTX3(1), RAF1(2), SRC(2) 16268817 151 85 147 77 31 38 16 49 15 2 0.999 1.000 1.000 200 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(2), ABP1(4), ACAT1(1), ACAT2(6), ACMSD(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(2), AOC2(3), AOC3(3), AOX1(10), ASMT(1), CAT(1), CYP19A1(4), CYP1A1(4), CYP2A13(4), CYP2A6(6), CYP2A7(12), CYP2B6(4), CYP2C18(4), CYP2C8(3), CYP2C9(4), CYP2D6(3), CYP2E1(2), CYP2F1(3), CYP2J2(4), CYP3A4(1), CYP3A5(4), CYP3A7(6), CYP4B1(6), CYP4F8(1), CYP51A1(2), DDC(4), ECHS1(2), EHHADH(14), GCDH(2), HAAO(1), HADHA(3), KMO(3), KYNU(4), MAOA(4), MAOB(3), SDS(4), TDO2(5), TPH1(3), WARS(6), WARS2(1) 16553027 185 85 181 73 44 42 19 51 29 0 0.905 1.000 1.000 201 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 26 ARHGDIB(1), CASP10(4), CASP3(2), CASP6(2), CASP7(4), CASP8(3), CFLAR(2), DAXX(1), DFFA(2), DFFB(3), FADD(2), FAF1(6), JUN(1), LMNA(3), LMNB1(5), LMNB2(4), MAP2K4(4), MAP3K1(6), MAP3K7(3), PAK1(4), PAK2(8), PRKDC(26), PTPN13(21), RIPK2(2), SPTAN1(9) 12420865 128 84 126 45 26 30 11 36 25 0 0.627 1.000 1.000 202 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(2), AGPAT1(3), AGPAT2(1), AGPAT3(4), AGPAT4(1), AGPAT6(5), CDIPT(1), CDS1(1), CDS2(1), CHAT(5), CHKA(1), CHPT1(3), DGKA(5), DGKB(2), DGKD(4), DGKE(4), DGKG(6), DGKH(4), DGKI(4), DGKZ(7), ESCO1(4), ESCO2(5), ETNK1(2), ETNK2(1), GNPAT(5), GPAM(9), GPD1(1), GPD1L(4), LCAT(3), LYPLA1(1), LYPLA2(2), NAT6(2), PCYT1A(4), PCYT1B(2), PEMT(2), PHOSPHO1(1), PISD(2), PLA2G12A(2), PLA2G12B(2), PLA2G1B(1), PLA2G2A(1), PLA2G2D(3), PLA2G2E(1), PLA2G2F(6), PLA2G3(4), PLA2G4A(6), PLA2G6(6), PLD1(6), PLD2(5), PNPLA3(3), PPAP2A(3), PPAP2B(1), PPAP2C(4), PTDSS1(2), PTDSS2(1), SH3GLB1(2) 20088499 173 84 172 75 38 39 26 44 26 0 0.954 1.000 1.000 203 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 72 B2M(1), CALR(6), CANX(5), CD4(3), CD74(1), CD8A(1), CD8B(4), CIITA(5), CREB1(1), CTSB(2), CTSL1(2), HLA-A(11), HLA-B(6), HLA-C(1), HLA-DMA(4), HLA-DMB(4), HLA-DOA(1), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(8), HLA-DQA1(4), HLA-DQA2(1), HLA-DQB1(3), HLA-DRB1(4), HLA-DRB5(3), HLA-E(4), HLA-G(1), HSP90AA1(10), HSP90AB1(4), HSPA5(4), IFNA13(1), IFNA14(2), IFNA16(2), IFNA17(6), IFNA2(2), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(5), IFNA8(2), KIR2DL1(4), KIR3DL1(2), KIR3DL3(1), KLRC1(1), KLRC2(1), KLRC4(2), KLRD1(1), LGMN(1), LTA(2), NFYA(4), NFYC(2), PSME1(1), PSME2(2), RFX5(4), RFXANK(1), RFXAP(1), TAP1(3), TAP2(2), TAPBP(2) 14055759 171 84 165 78 32 27 24 60 28 0 0.997 1.000 1.000 204 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(2), ACTR3(3), AKT1(2), DGKA(5), ETFA(1), GCA(2), ITGA9(8), ITPKA(1), ITPKB(2), ITPR1(18), ITPR2(19), ITPR3(15), MAP2K1(5), MAPK1(3), MAPK3(1), PAK1(4), PDE3A(7), PDE3B(9), PI3(2), PIK3C2G(11), PIK3CA(10), PIK3CD(5), PIK3R1(5), PSME1(1), RIPK3(5), SGCB(2), VASP(3) 14935328 151 84 149 58 45 32 18 42 13 1 0.809 1.000 1.000 205 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(8), CSK(2), CTLA4(3), EPHB2(7), FBXW7(3), GRAP2(3), ITK(2), ITPKA(1), ITPKB(2), LCK(5), LCP2(4), MAPK1(3), NCK1(1), NFAT5(13), NFKB1(7), NFKB2(2), NFKBIA(2), NFKBIE(1), NFKBIL1(3), PAK1(4), PAK2(8), PAK3(6), PAK4(3), PAK6(4), PAK7(9), PLCG1(10), PTPRC(9), RAF1(2), RASGRP1(9), RASGRP2(3), RASGRP3(4), RASGRP4(6), SOS1(10), SOS2(8), VAV1(6), ZAP70(3) 17216741 176 84 175 76 47 47 17 45 19 1 0.960 1.000 1.000 206 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(1), ALPL(3), ALPP(6), ALPPL2(3), ASCC3(15), ATP13A2(8), DDX18(4), DDX19A(2), DDX23(4), DDX4(3), DDX41(3), DDX47(2), DDX50(4), DDX51(4), DDX52(5), DDX54(4), DDX55(4), DDX56(1), DHX58(6), ENTPD7(4), EP400(12), ERCC2(5), ERCC3(4), FPGS(4), GGH(1), IFIH1(5), MOV10L1(2), NUDT5(1), PTS(2), QDPR(1), RAD54B(5), RAD54L(2), RUVBL2(1), SETX(20), SKIV2L2(4), SMARCA2(11), SMARCA5(2) 18987859 168 83 166 102 40 47 14 43 22 2 1.000 1.000 1.000 207 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(2), EGF(10), EGFR(7), FOS(2), JAK1(8), JUN(1), MAP2K1(5), MAP2K4(4), MAP3K1(6), MAPK3(1), PIK3CA(10), PIK3R1(5), PLCG1(10), PRKCA(2), RAF1(2), RASA1(10), SHC1(5), SOS1(10), SRF(1), STAT1(7), STAT3(5), STAT5A(2) 11315737 115 81 114 38 19 33 13 26 23 1 0.642 1.000 1.000 208 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 34 ACTA1(2), DOCK1(14), FOS(2), GAB1(5), HGF(9), ITGA1(7), ITGB1(3), JUN(1), MAP2K1(5), MAP2K2(3), MAP4K1(5), MAPK1(3), MAPK3(1), MET(2), PAK1(4), PIK3CA(10), PIK3R1(5), PTK2(9), PTK2B(8), PTPN11(2), PXN(5), RAF1(2), RAP1A(2), RASA1(10), SOS1(10), SRC(2), STAT3(5) 13435691 136 81 135 43 28 41 16 33 17 1 0.335 1.000 1.000 209 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 52 ACTA1(2), AGT(2), AKT1(2), CALM1(1), CALR(6), CAMK1G(3), CAMK4(1), CREBBP(12), CSNK1A1(1), EDN1(2), ELSPBP1(9), F2(2), GATA4(1), GSK3B(6), HAND2(2), IGF1(1), LIF(1), MAP2K1(5), MAPK1(3), MAPK14(4), MAPK3(1), MEF2C(3), MYH2(14), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), NKX2-5(1), NPPA(1), PIK3CA(10), PIK3R1(5), PPP3CA(6), PPP3CB(5), PPP3CC(1), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), RAF1(2), RPS6KB1(5), SYT1(1) 15012655 146 81 142 47 39 40 15 32 19 1 0.423 1.000 1.000 210 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(7), CDA(2), CTPS2(3), DCTD(1), DHODH(4), DPYD(17), DUT(2), ENTPD1(6), NME1(1), NT5C(1), POLB(4), POLD1(5), POLE(9), POLG(7), POLL(1), POLQ(18), POLR1B(3), POLR2A(10), POLR2B(8), POLR2C(1), POLR2E(2), POLR2G(2), POLR2H(1), POLR2I(2), POLRMT(1), RRM1(5), RRM2(2), TK1(2), TK2(3), TXNRD1(1), UCK2(3), UMPS(2), UNG(4), UPB1(1), UPP1(1) 17355819 142 81 140 63 32 40 13 38 19 0 0.961 1.000 1.000 211 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 57 APC(12), AXIN1(14), CCND1(1), CCND2(1), CSNK1E(3), DVL1(1), DVL2(5), FBXW2(5), FOSL1(1), FZD1(1), FZD10(5), FZD2(3), FZD3(4), FZD5(2), FZD6(4), FZD7(1), FZD8(2), FZD9(6), GSK3B(6), JUN(1), LDLR(5), MAPK10(4), MAPK9(4), MYC(2), PAFAH1B1(1), PLAU(6), PPP2R5C(4), PPP2R5E(2), PRKCA(2), PRKCD(4), PRKCG(2), PRKCH(2), PRKCI(1), PRKCQ(2), PRKCZ(3), PRKD1(7), RAC1(1), SFRP4(3), TCF7(5), WNT1(3), WNT10B(1), WNT16(2), WNT2(3), WNT4(1), WNT5B(1), WNT6(2), WNT7A(2), WNT7B(1) 16658319 154 81 150 82 28 37 13 41 34 1 1.000 1.000 1.000 212 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(2), ADH1B(6), ADH5(1), ADH6(2), ADH7(3), ADHFE1(1), AKR1C1(2), AKR1C2(4), AKR1C3(1), AKR1C4(3), ALDH1A3(2), ALDH3A1(3), ALDH3B1(5), ALDH3B2(4), CYP1A1(4), CYP1B1(2), CYP2B6(4), CYP2C18(4), CYP2C8(3), CYP2C9(4), CYP2E1(2), CYP2F1(3), CYP2S1(2), CYP3A4(1), CYP3A43(3), CYP3A5(4), CYP3A7(6), DHDH(1), EPHX1(4), GSTA2(2), GSTA4(2), GSTA5(1), GSTK1(1), GSTM2(1), GSTM3(1), GSTM5(2), GSTO2(2), GSTP1(4), GSTT1(1), GSTT2(3), GSTZ1(2), MGST1(1), MGST3(1), UGT1A1(1), UGT1A10(3), UGT1A3(2), UGT1A4(1), UGT1A5(13), UGT1A8(1), UGT1A9(1), UGT2A1(5), UGT2A3(3), UGT2B10(2), UGT2B11(3), UGT2B15(5), UGT2B17(1), UGT2B4(5), UGT2B7(5) 16991771 161 80 156 94 30 40 15 43 32 1 1.000 1.000 1.000 213 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(2), ASAH1(4), ATF1(2), BRAF(2), CAMP(1), CREB1(1), CREB3(2), CREB5(5), CREBBP(12), EGR2(3), EGR3(5), EGR4(1), FRS2(1), JUN(1), MAP1B(12), MAP2K4(4), MAP2K7(2), MAPK1(3), MAPK10(4), MAPK3(1), MAPK8IP3(2), MAPK9(4), NTRK1(5), PIK3C2G(11), PIK3CA(10), PIK3CD(5), PIK3R1(5), PTPN11(2), RPS6KA3(10), SHC1(5), SRC(2), TERF2IP(1), TH(3) 15747673 133 80 132 47 28 38 18 33 15 1 0.587 1.000 1.000 214 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM1(1), FOS(2), FYN(2), JUN(1), LCK(5), MAP2K1(5), MAP2K4(4), MAP3K1(6), MAPK3(1), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), NFKB1(7), NFKBIA(2), PIK3CA(10), PIK3R1(5), PLCG1(10), PPP3CA(6), PPP3CB(5), PPP3CC(1), PRKCA(2), PTPN7(2), RAC1(1), RAF1(2), RASA1(10), RELA(4), SHC1(5), SOS1(10), SYT1(1), VAV1(6), ZAP70(3) 14277764 135 80 134 53 27 31 16 39 21 1 0.893 1.000 1.000 215 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(2), AGPAT1(3), AGPAT2(1), AGPAT3(4), AGPAT4(1), AGPS(3), CDIPT(1), CDS1(1), CDS2(1), CHAT(5), CHKA(1), CLC(1), CPT1B(4), DGKA(5), DGKB(2), DGKD(4), DGKE(4), DGKG(6), DGKH(4), DGKZ(7), ETNK1(2), GNPAT(5), GPD1(1), LCAT(3), LYPLA1(1), LYPLA2(2), PAFAH1B1(1), PAFAH2(1), PCYT1A(4), PCYT1B(2), PEMT(2), PISD(2), PLA2G1B(1), PLA2G2A(1), PLA2G2E(1), PLA2G3(4), PLA2G4A(6), PLA2G6(6), PLCB2(4), PLCG1(10), PLCG2(16), PPAP2A(3), PPAP2B(1), PPAP2C(4) 15359531 143 79 142 62 36 39 18 33 17 0 0.950 1.000 1.000 216 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 53 AKR1C4(3), AKR1D1(3), ARSD(5), ARSE(2), CARM1(2), CYP11B1(4), CYP11B2(9), CYP19A1(4), HEMK1(5), HSD11B1(2), HSD17B2(1), HSD17B3(3), HSD17B7(2), HSD3B1(1), LCMT1(2), LCMT2(4), METTL2B(6), METTL6(1), PRMT3(2), PRMT5(4), PRMT6(4), PRMT7(1), PRMT8(3), STS(3), SULT1E1(1), SULT2A1(3), SULT2B1(3), UGT1A1(1), UGT1A10(3), UGT1A3(2), UGT1A4(1), UGT1A5(13), UGT1A8(1), UGT1A9(1), UGT2A1(5), UGT2A3(3), UGT2B10(2), UGT2B11(3), UGT2B15(5), UGT2B17(1), UGT2B4(5), UGT2B7(5), WBSCR22(1) 14326357 135 79 133 73 28 35 15 40 15 2 0.999 1.000 1.000 217 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(2), AASDHPPT(2), AASS(8), ACAT1(1), ACAT2(6), AKR1B10(1), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH7A1(2), ALDH9A1(2), BBOX1(1), DLST(2), DOT1L(9), ECHS1(2), EHHADH(14), EHMT1(5), EHMT2(7), GCDH(2), HADH(1), HADHA(3), HSD17B4(8), HSD3B7(2), NSD1(14), OGDH(4), OGDHL(2), PIPOX(2), PLOD1(5), PLOD2(7), PLOD3(1), RDH11(2), RDH12(2), RDH13(1), SETD1A(7), SETD7(3), SETDB1(5), SHMT1(4), SHMT2(2), SPCS1(1), SPCS3(1), SUV39H1(1), SUV39H2(3), TMLHE(2) 17254068 159 78 158 61 37 30 18 50 24 0 0.788 1.000 1.000 218 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(2), ADH1B(6), ADH5(1), ADH6(2), ADH7(3), ADHFE1(1), AGK(2), AGPAT1(3), AGPAT2(1), AGPAT3(4), AGPAT4(1), AGPAT6(5), AKR1A1(3), AKR1B1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH7A1(2), ALDH9A1(2), CEL(2), DAK(1), DGAT1(2), DGAT2(1), DGKA(5), DGKB(2), DGKD(4), DGKE(4), DGKG(6), DGKH(4), DGKI(4), DGKZ(7), GK(3), GK2(3), GLA(1), GLB1(6), GPAM(9), LCT(7), LIPA(5), LIPC(6), LIPF(3), LIPG(2), LPL(4), MGLL(1), PNLIP(1), PNLIPRP1(5), PNLIPRP2(2), PNPLA3(3), PPAP2A(3), PPAP2B(1), PPAP2C(4) 17917138 161 78 159 94 32 38 25 38 28 0 1.000 1.000 1.000 219 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 BCL2(1), CHUK(9), DAXX(1), EGF(10), EGFR(7), ETS1(1), ETS2(2), FOS(2), IKBKB(6), JUN(1), MAP2K1(5), MAP2K4(4), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K14(2), MAP3K5(6), MAPK1(3), MAPK13(1), MAPK14(4), MAPK3(1), NFKB1(7), NFKBIA(2), PPP2CA(4), PRKCA(2), PRKCD(4), PRKCG(2), PRKCH(2), PRKCQ(2), RAF1(2), RELA(4), RIPK1(6), SP1(2), TNF(2), TNFRSF1A(2), TNFRSF1B(3) 14232946 121 78 121 65 26 26 15 33 21 0 1.000 1.000 1.000 220 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(16), B3GALT4(3), CDR1(2), DGKI(4), FAU(1), MRPL19(1), RPL10(2), RPL11(1), RPL13(2), RPL15(1), RPL18(3), RPL18A(1), RPL22(1), RPL23(1), RPL27(1), RPL29(1), RPL3(2), RPL37(1), RPL38(1), RPL3L(1), RPL4(1), RPL41(1), RPL5(2), RPL6(2), RPL7A(2), RPL9(1), RPS10(1), RPS13(2), RPS14(1), RPS18(1), RPS2(1), RPS23(1), RPS24(1), RPS27A(2), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(2), RPS6(1), RPS6KA1(4), RPS6KA2(6), RPS6KA3(10), RPS6KA6(9), RPS6KB1(5), RPS6KB2(3), RPS9(2), SLC36A2(8), TBC1D10C(1), UBA52(1), UBC(4) 15040520 125 77 125 55 27 33 19 26 20 0 0.932 1.000 1.000 221 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(2), FOS(2), JAK1(8), JUN(1), MAP2K1(5), MAP2K4(4), MAP3K1(6), MAPK3(1), PDGFA(2), PDGFRA(10), PIK3CA(10), PIK3R1(5), PLCG1(10), PRKCA(2), RAF1(2), RASA1(10), SHC1(5), SOS1(10), SRF(1), STAT1(7), STAT3(5), STAT5A(2) 10566493 110 76 109 34 22 29 14 24 20 1 0.483 1.000 1.000 222 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(2), AKT2(7), AKT3(4), ANKRD6(4), APC(12), AXIN1(14), AXIN2(8), CER1(3), CSNK1A1(1), DACT1(5), DKK1(2), DKK2(4), DKK3(3), DKK4(1), DVL1(1), FSTL1(1), GSK3A(2), GSK3B(6), LRP1(19), MVP(1), NKD1(2), NKD2(1), PIN1(1), PSEN1(2), PTPRA(5), SENP2(5), WIF1(5) 11668172 121 76 120 55 15 24 12 39 28 3 0.996 1.000 1.000 223 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 27 ARHGDIB(1), BAG4(5), CASP2(1), CASP3(2), CASP8(3), CRADD(1), DFFA(2), DFFB(3), FADD(2), JUN(1), LMNA(3), LMNB1(5), LMNB2(4), MADD(6), MAP2K4(4), MAP3K1(6), MAP3K7(3), PAK1(4), PAK2(8), PRKDC(26), RIPK1(6), SPTAN1(9), TNF(2), TNFRSF1A(2) 11466119 109 76 107 47 21 25 9 31 23 0 0.959 1.000 1.000 224 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(2), CALM1(1), CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), CDK5(1), F2(2), FYN(2), GNAI1(4), GNB1(4), GNGT1(1), JAK2(9), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK14(4), MAPK3(1), MAPT(12), MYLK(4), PLCG1(10), PRKCA(2), PTK2B(8), RAF1(2), SHC1(5), SOS1(10), STAT1(7), STAT3(5), STAT5A(2), SYT1(1) 12786358 123 75 123 41 30 41 9 19 23 1 0.661 1.000 1.000 225 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(1), CALM1(1), FCER1A(2), FOS(2), JUN(1), LYN(3), MAP2K1(5), MAP2K4(4), MAP2K7(2), MAP3K1(6), MAPK1(3), MAPK3(1), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), PAK2(8), PIK3CA(10), PIK3R1(5), PLA2G4A(6), PLCG1(10), PPP3CA(6), PPP3CB(5), PPP3CC(1), RAF1(2), SHC1(5), SOS1(10), SYK(4), SYT1(1), VAV1(6) 12740850 126 75 125 48 28 31 16 34 16 1 0.755 1.000 1.000 226 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(11), ATP4A(8), ATP4B(1), ATP5A1(3), ATP5B(3), ATP5C1(2), ATP5D(1), ATP5F1(1), ATP5G1(1), ATP5G2(1), ATP5G3(2), ATP5H(1), ATP5L(2), ATP6AP1(2), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(1), ATP6V0D2(3), ATP6V1A(3), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(3), ATP6V1D(2), ATP6V1E2(1), ATP6V1F(2), ATP6V1G3(1), ATP6V1H(2), COX10(3), COX15(3), COX4I1(1), COX4I2(1), COX5A(2), COX5B(2), COX6A1(1), COX6B1(1), CYC1(1), LHPP(1), NDUFA1(1), NDUFA10(5), NDUFA5(2), NDUFA8(1), NDUFA9(1), NDUFAB1(1), NDUFB11(1), NDUFB5(1), NDUFB7(1), NDUFB8(1), NDUFC2(1), NDUFS1(3), NDUFS2(1), NDUFS4(2), NDUFV2(2), NDUFV3(4), PPA1(2), PPA2(4), SDHA(5), SDHB(3), UQCRB(1), UQCRC2(1), UQCRFS1(2), UQCRH(1) 17045140 142 75 138 76 31 36 17 42 16 0 0.999 1.000 1.000 227 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(4), AGXT(5), AGXT2(3), AKR1B10(1), ALAS1(2), ALAS2(3), AMT(1), AOC2(3), AOC3(3), BHMT(2), CBS(5), CHDH(7), CHKA(1), CTH(3), DAO(7), DLD(2), DMGDH(3), GAMT(1), GARS(2), GATM(6), GCAT(2), GLDC(9), GNMT(1), HSD3B7(2), MAOA(4), MAOB(3), PEMT(2), PHGDH(5), PIPOX(2), PISD(2), PSAT1(3), PSPH(2), RDH11(2), RDH12(2), RDH13(1), SARDH(6), SARS(2), SARS2(4), SDS(4), SHMT1(4), SHMT2(2), TARS(4), TARS2(4) 13001648 136 75 136 49 36 32 15 36 17 0 0.721 1.000 1.000 228 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(2), AKT2(7), AKT3(4), CISH(2), IARS(9), IL13RA1(5), IL2RG(1), IL4(1), IL4R(4), INPP5D(3), JAK1(8), JAK2(9), JAK3(5), NR0B2(3), PI3(2), PIK3CA(10), PPP1R13B(7), RPS6KB1(5), SERPINA4(3), SHC1(5), SOS1(10), SOS2(8), SRC(2), STAT6(6), TYK2(7) 11055864 128 75 127 33 29 39 17 27 15 1 0.0668 1.000 1.000 229 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(2), EIF1(1), EIF2B2(2), EIF2B3(3), EIF2B4(1), EIF2B5(5), EIF2S1(1), EIF2S2(1), EIF2S3(2), ELAVL1(5), FLT1(11), FLT4(9), HIF1A(3), KDR(13), NOS3(8), PIK3CA(10), PIK3R1(5), PLCG1(10), PRKCA(2), PTK2(9), PXN(5), SHC1(5), VHL(1) 10459780 114 75 111 37 21 37 7 33 16 0 0.532 1.000 1.000 230 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(2), ACTN1(5), ACTN2(8), ACTN3(1), BCAR1(3), BCR(4), CAPN1(3), CAPNS1(1), CAV1(1), CSK(2), FYN(2), ITGA1(7), ITGB1(3), JUN(1), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), PPP1R12B(5), PTK2(9), PXN(5), RAF1(2), RAP1A(2), ROCK1(7), SHC1(5), SOS1(10), SRC(2), TLN1(12), VCL(4), ZYX(2) 14264277 120 74 120 37 26 29 15 32 17 1 0.519 1.000 1.000 231 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(2), AASDH(8), AASDHPPT(2), AASS(8), ACAT1(1), ACAT2(6), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(2), ATP6V0C(1), BBOX1(1), DLST(2), DOT1L(9), ECHS1(2), EHHADH(14), EHMT1(5), EHMT2(7), GCDH(2), HADHA(3), PLOD1(5), PLOD2(7), PLOD3(1), SDS(4), SHMT1(4), SHMT2(2), TMLHE(2) 10951605 114 74 113 52 21 24 10 40 19 0 0.973 1.000 1.000 232 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(2), ACSS2(3), ACYP1(1), ACYP2(1), ADH1A(2), ADH1B(6), ADH5(1), ADH6(2), ADH7(3), ADHFE1(1), AKR1A1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(5), ALDH3B2(4), ALDH7A1(2), ALDH9A1(2), ALDOB(3), DLAT(4), DLD(2), ENO1(2), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(4), G6PC2(4), GALM(1), GAPDHS(6), GCK(3), GPI(2), HK1(4), HK2(8), HK3(6), LDHA(1), LDHAL6A(2), LDHAL6B(7), LDHB(2), LDHC(2), PDHA1(1), PDHA2(4), PDHB(2), PFKL(3), PFKM(2), PFKP(6), PGAM1(1), PGAM2(1), PGAM4(1), PGK1(2), PGK2(2), PGM1(3), PGM3(6), PKLR(1) 17446419 151 73 148 87 41 30 14 34 31 1 1.000 1.000 1.000 233 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(1), ALOX12(1), ALOX12B(4), ALOX15(3), ALOX15B(4), ALOX5(4), CBR3(2), CYP2B6(4), CYP2C18(4), CYP2C8(3), CYP2C9(4), CYP2E1(2), CYP2J2(4), CYP2U1(3), CYP4A11(5), CYP4A22(4), CYP4F2(3), CYP4F3(1), DHRS4(3), EPHX2(2), GPX1(2), GPX2(2), GPX5(2), GPX6(2), GPX7(1), LTA4H(5), PLA2G12A(2), PLA2G12B(2), PLA2G1B(1), PLA2G2A(1), PLA2G2D(3), PLA2G2E(1), PLA2G2F(6), PLA2G3(4), PLA2G4A(6), PLA2G6(6), PTGES(1), PTGES2(2), PTGIS(2), PTGS1(3), PTGS2(2), TBXAS1(2) 12037237 119 73 117 60 30 27 16 32 14 0 0.998 1.000 1.000 234 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 49 ABL1(1), ACTB(1), ACTG1(1), ARHGEF2(6), CDC42(2), CDH1(4), CLDN1(1), CTTN(5), EZR(5), FYN(2), ITGB1(3), KRT18(1), LY96(1), NCK1(1), NCK2(2), OCLN(1), PRKCA(2), ROCK1(7), ROCK2(8), TLR4(3), TLR5(3), TUBA1A(1), TUBA1C(1), TUBA3C(5), TUBA3D(3), TUBA3E(17), TUBA4A(1), TUBA8(4), TUBAL3(3), TUBB(1), TUBB1(3), TUBB2A(1), TUBB2B(1), TUBB3(1), TUBB6(1), TUBB8(3), WAS(2), WASL(2), YWHAZ(1) 14816339 111 73 100 65 18 23 16 34 20 0 1.000 1.000 1.000 235 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 49 ABL1(1), ACTB(1), ACTG1(1), ARHGEF2(6), CDC42(2), CDH1(4), CLDN1(1), CTTN(5), EZR(5), FYN(2), ITGB1(3), KRT18(1), LY96(1), NCK1(1), NCK2(2), OCLN(1), PRKCA(2), ROCK1(7), ROCK2(8), TLR4(3), TLR5(3), TUBA1A(1), TUBA1C(1), TUBA3C(5), TUBA3D(3), TUBA3E(17), TUBA4A(1), TUBA8(4), TUBAL3(3), TUBB(1), TUBB1(3), TUBB2A(1), TUBB2B(1), TUBB3(1), TUBB6(1), TUBB8(3), WAS(2), WASL(2), YWHAZ(1) 14816339 111 73 100 65 18 23 16 34 20 0 1.000 1.000 1.000 236 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(10), AR(12), ESR1(4), ESR2(3), ESRRA(4), HNF4A(1), NPM1(3), NR0B1(1), NR1D1(3), NR1H2(3), NR1H3(3), NR1I2(1), NR2C2(4), NR2E1(1), NR2F2(4), NR3C1(4), NR4A1(4), NR4A2(5), NR5A1(2), NR5A2(3), PGR(8), PPARA(4), PPARD(1), PPARG(1), RARA(2), RARB(3), RARG(7), ROR1(7), RORA(3), RORC(1), RXRA(6), RXRB(5), RXRG(2), THRA(1), THRB(1), VDR(2) 12733927 129 73 126 61 22 31 18 41 17 0 0.994 1.000 1.000 237 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(4), AGMAT(3), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH4A1(4), ALDH9A1(2), AMD1(3), AOC2(3), AOC3(3), ARG1(3), ARG2(2), ASL(2), CKB(1), CKM(2), CKMT1A(1), CKMT1B(1), CKMT2(5), CPS1(10), DAO(7), GAMT(1), GATM(6), GLUD1(3), GOT1(2), GOT2(2), MAOA(4), MAOB(3), NOS1(15), NOS3(8), OAT(3), ODC1(3), OTC(3), P4HA1(1), P4HA2(4), P4HA3(2), P4HB(1), PYCR1(2), RARS(3), SMS(1) 13552394 137 72 136 63 29 34 10 49 15 0 0.991 1.000 1.000 238 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 26 BRCA1(11), CARM1(2), CCND1(1), CREBBP(12), EP300(7), ERCC3(4), ESR1(4), GRIP1(7), GTF2A1(3), GTF2E1(3), GTF2F1(1), HDAC2(5), HDAC3(2), HDAC4(5), HDAC5(3), HDAC6(8), MEF2C(3), NCOR2(11), NR0B1(1), NRIP1(4), PELP1(8), POLR2A(10), SRA1(2) 14356353 117 72 116 67 34 24 14 26 18 1 0.999 1.000 1.000 239 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(4), CDT1(3), DIAPH2(6), GMNN(2), MCM10(6), MCM2(5), MCM3(3), MCM4(4), MCM5(3), MCM6(4), MCM7(6), NACA(6), POLA2(1), POLD1(5), POLD3(1), POLE(9), POLE2(7), PRIM1(2), RFC1(7), RFC2(2), RFC3(2), RFC4(1), RFC5(3), RPA1(5), RPA2(2), RPA3(1), RPS27A(2), UBA52(1), UBC(4) 15310592 108 72 107 53 19 28 12 36 13 0 0.973 1.000 1.000 240 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(7), GNAS(9), GNB1(4), GNGT1(1), IGF1R(12), ITGB1(3), KLK2(3), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MKNK1(2), MKNK2(1), MYC(2), NGFR(1), PDGFRA(10), PPP2CA(4), PTPRR(4), RAF1(2), RPS6KA1(4), RPS6KA5(3), SHC1(5), SOS1(10), SRC(2), STAT3(5) 10081925 106 72 103 35 32 25 13 27 8 1 0.506 1.000 1.000 241 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(10), ACACB(14), ACAT1(1), ACAT2(6), ACOT12(5), ACSS1(2), ACSS2(3), ACYP1(1), ACYP2(1), AKR1B1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH7A1(2), ALDH9A1(2), DLAT(4), DLD(2), GLO1(5), HAGH(2), HAGHL(2), LDHA(1), LDHAL6A(2), LDHAL6B(7), LDHB(2), LDHC(2), LDHD(1), MDH1(1), MDH2(2), ME1(1), ME2(5), ME3(1), PC(10), PCK1(6), PDHA1(1), PDHA2(4), PDHB(2), PKLR(1) 13861092 123 72 121 76 29 25 24 30 15 0 1.000 1.000 1.000 242 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(2), BCL2(1), CBL(8), CFLAR(2), E2F1(2), FOS(2), IL2RA(2), IL2RB(3), IL2RG(1), IRS1(4), JAK1(8), JAK3(5), MAPK1(3), MAPK3(1), MYC(2), NMI(4), PIK3CA(10), PIK3R1(5), PPIA(2), PTPN6(2), RAF1(2), RPS6KB1(5), SHC1(5), SOS1(10), STAT5A(2), STAT5B(3), SYK(4) 10862168 100 72 99 30 29 24 13 21 12 1 0.315 1.000 1.000 243 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(7), COL4A2(10), COL4A3(4), COL4A4(11), COL4A5(9), COL4A6(11), F10(3), F2(2), F2R(2), F5(18), F8(11), F9(1), FGA(9), FGB(2), FGG(4), KLKB1(7), PROC(5), PROS1(4), SERPINC1(4), SERPING1(1) 13531048 125 72 121 68 22 37 23 32 11 0 0.924 1.000 1.000 244 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 35 AKT1(2), AKT2(7), AKT3(4), ARHGEF11(5), BCL2(1), CDC42(2), DLG4(3), GNA13(2), LPA(10), MAP2K4(4), MAP3K1(6), MAP3K5(6), NFKB1(7), NFKB2(2), NFKBIA(2), NFKBIE(1), NFKBIL1(3), PDK1(1), PHKA2(5), PI3(2), PIK3CB(12), PLD1(6), PLD2(5), PLD3(5), PTK2(9), RDX(4), ROCK1(7), ROCK2(8), SERPINA4(3), SRF(1) 15279265 135 72 134 58 23 39 15 33 24 1 0.961 1.000 1.000 245 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(14), EEF1A2(3), EEF1G(2), EEF2(2), EEF2K(5), EIF1AX(1), EIF2AK1(4), EIF2AK2(3), EIF2AK3(9), EIF2B2(2), EIF2B3(3), EIF2B4(1), EIF2B5(5), EIF2S1(1), EIF2S2(1), EIF2S3(2), EIF4A1(1), EIF4A2(2), EIF4E(2), EIF4EBP1(1), EIF4EBP2(1), EIF4G1(10), EIF4G3(10), EIF5(2), EIF5A(2), EIF5B(4), ETF1(3), PABPC1(9), PABPC3(8), SLC35A4(1) 13319673 114 72 110 54 23 35 16 22 17 1 0.935 1.000 1.000 246 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(4), AGXT(5), AGXT2(3), ALAS1(2), ALAS2(3), AMT(1), AOC2(3), AOC3(3), ATP6V0C(1), BHMT(2), CBS(5), CHDH(7), CHKA(1), CPT1B(4), CTH(3), DAO(7), DLD(2), DMGDH(3), GAMT(1), GARS(2), GATM(6), GCAT(2), GLDC(9), MAOA(4), MAOB(3), PEMT(2), PISD(2), PLCB2(4), PLCG1(10), PLCG2(16), PSPH(2), SARDH(6), SARS(2), SHMT1(4), SHMT2(2), TARS(4) 12761200 140 71 140 51 36 40 15 32 17 0 0.762 1.000 1.000 247 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(3), DLAT(4), DLD(2), ENO1(2), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(4), GAPDHS(6), GCK(3), GOT1(2), GOT2(2), GPI(2), HK1(4), HK2(8), HK3(6), LDHA(1), LDHAL6B(7), LDHB(2), LDHC(2), MDH1(1), MDH2(2), PC(10), PCK1(6), PDHA1(1), PDHA2(4), PDHB(2), PDHX(4), PFKL(3), PFKM(2), PFKP(6), PGAM1(1), PGAM2(1), PGK1(2), PGK2(2), PKLR(1), TNFAIP1(1) 12570232 114 71 113 62 33 31 15 18 17 0 0.997 1.000 1.000 248 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(3), ACAA1(2), ACAA2(2), ACADM(1), ACADS(3), ACAT1(1), ACAT2(6), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH6A1(6), ALDH7A1(2), ALDH9A1(2), AOX1(10), AUH(2), BCAT1(5), BCAT2(2), BCKDHA(4), BCKDHB(2), DBT(3), DLD(2), ECHS1(2), EHHADH(14), HADH(1), HADHA(3), HADHB(2), HIBADH(1), HIBCH(5), HMGCL(1), HMGCS1(4), HMGCS2(3), HSD17B4(8), IVD(2), MCCC1(4), MCCC2(1), MUT(4), OXCT1(7), PCCA(3), PCCB(5) 13191510 138 71 137 54 30 39 15 34 20 0 0.592 1.000 1.000 249 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(4), ARG1(3), ARG2(2), ASL(2), ASS1(2), CKB(1), CKM(2), CKMT1A(1), CKMT1B(1), CKMT2(5), CPS1(10), DAO(7), EPRS(7), GAMT(1), GATM(6), GLUD1(3), GLUD2(3), GOT1(2), GOT2(2), LAP3(4), NOS1(15), NOS3(8), OAT(3), OTC(3), P4HA1(1), P4HA2(4), P4HA3(2), PARS2(4), PRODH(3), PYCR1(2), PYCR2(1), PYCRL(2), RARS(3), RARS2(5) 11160757 124 71 123 55 26 29 10 44 14 1 0.978 1.000 1.000 250 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(3), ABO(1), B3GALNT1(3), B3GALT1(1), B3GALT2(1), B3GALT4(3), B3GNT2(2), B3GNT4(1), B4GALNT1(4), B4GALT2(2), B4GALT3(2), B4GALT4(1), B4GALT6(5), FUT1(2), FUT2(1), FUT3(3), FUT5(4), FUT6(3), FUT7(2), FUT9(2), GBGT1(4), GCNT2(7), PIGA(3), PIGB(3), PIGC(1), PIGF(3), PIGG(5), PIGH(2), PIGL(3), PIGM(6), PIGN(8), PIGO(4), PIGQ(5), PIGS(6), PIGU(2), PIGV(1), PIGX(2), PIGZ(4), ST3GAL1(1), ST3GAL3(4), ST3GAL4(1), ST3GAL5(2), ST3GAL6(3), ST6GALNAC3(4), ST6GALNAC4(1), ST6GALNAC5(3), ST6GALNAC6(1), ST8SIA1(4), ST8SIA5(1), UGCG(2) 14718015 142 71 140 52 35 30 14 45 18 0 0.796 1.000 1.000 251 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(2), AKT2(7), AKT3(4), BCL2(1), GSK3A(2), GSK3B(6), IL4R(4), IRS1(4), IRS2(2), JAK1(8), JAK3(5), MAP4K1(5), MAPK1(3), MAPK3(1), PDK1(1), PIK3CA(10), PIK3CD(5), PIK3R1(5), PPP1R13B(7), RAF1(2), SHC1(5), SOS1(10), SOS2(8), STAT6(6) 10864619 113 71 112 38 26 27 15 29 15 1 0.565 1.000 1.000 252 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(1), ACTG2(1), ACTR2(2), ACTR3(3), AKT1(2), CDC42(2), CFL1(3), CFL2(2), FLNA(8), FLNC(10), FSCN1(3), FSCN3(1), GDI1(2), GDI2(1), LIMK1(2), MYH2(14), MYLK(4), MYLK2(4), PAK1(4), PAK2(8), PAK3(6), PAK4(3), PAK6(4), PAK7(9), RHO(2), ROCK1(7), ROCK2(8), VASP(3), WASF1(2), WASL(2) 14521490 123 71 122 57 24 35 11 26 27 0 0.991 1.000 1.000 253 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(1), AKT1(2), APC(12), ASAH1(4), CAMP(1), DLG4(3), EPHB2(7), GNAI1(4), ITPR1(18), ITPR2(19), ITPR3(15), KCNJ3(1), KCNJ5(1), MAPK1(3), PITX2(1), PTX3(1), RAC1(1), RHO(2), RYR1(26) 13971684 122 71 121 76 32 30 9 35 14 2 1.000 1.000 1.000 254 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 31 ACVR1(4), APC(12), ATF2(1), AXIN1(14), BMP10(1), BMP2(3), BMP4(1), BMP5(3), BMP7(3), BMPR1A(1), BMPR2(8), CHRD(2), DVL1(1), FZD1(1), GATA4(1), GSK3B(6), MAP3K7(3), MEF2C(3), NKX2-5(1), NOG(1), NPPA(1), NPPB(1), RFC1(7), TGFB1(1), TGFB2(4), TGFB3(3), TGFBR1(5), TGFBR2(1), TGFBR3(2), WNT1(3) 10427075 98 70 98 53 16 24 11 24 22 1 0.998 1.000 1.000 255 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(10), BAX(1), BCL2(1), BCL2A1(5), CASP1(4), CASP10(4), CASP2(1), CASP3(2), CASP4(4), CASP6(2), CASP7(4), CASP8(3), CASP9(1), CD40(4), CRADD(1), DAXX(1), DFFA(2), DFFB(3), FADD(2), FAS(5), FASLG(2), IKBKE(2), LTA(2), MCL1(2), NFKB1(7), NFKBIA(2), NGFR(1), NR3C1(4), NTRK1(5), PTPN13(21), RIPK1(6), TNF(2), TNFRSF1A(2), TNFRSF1B(3), TRAF1(3), TRAF3(1), TRAF6(1) 13166880 126 70 126 46 24 27 17 41 17 0 0.699 1.000 1.000 256 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(7), AKT1(2), ASAH1(4), GNAI1(4), GNB1(4), GNGT1(1), ITGAV(9), ITGB3(3), MAPK1(3), MAPK3(1), PDGFA(2), PDGFRA(10), PIK3CA(10), PIK3R1(5), PLCB1(11), PRKCA(2), PTK2(9), RAC1(1), SMPD1(3), SMPD2(2), SPHK1(6), SRC(2) 8136078 101 70 99 32 19 28 11 27 16 0 0.441 1.000 1.000 257 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(2), ADH1B(6), ADH6(2), ADH7(3), ADHFE1(1), AGPAT1(3), AGPAT2(1), AGPAT3(4), AGPAT4(1), AKR1A1(3), AKR1B1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(2), CEL(2), DGAT1(2), DGKA(5), DGKB(2), DGKD(4), DGKE(4), DGKG(6), DGKH(4), DGKZ(7), GK(3), GLA(1), GLB1(6), LCT(7), LIPC(6), LIPF(3), LIPG(2), LPL(4), PNLIP(1), PNLIPRP1(5), PNLIPRP2(2), PPAP2A(3), PPAP2B(1), PPAP2C(4) 14767468 128 70 126 82 29 31 19 29 20 0 1.000 1.000 1.000 258 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(5), AARS2(7), CARS(4), CARS2(2), DARS(1), EARS2(1), EPRS(7), FARS2(2), FARSA(1), FARSB(1), GARS(2), HARS(1), HARS2(3), IARS(9), IARS2(2), KARS(1), LARS(5), LARS2(2), MARS(7), MARS2(1), MTFMT(2), NARS2(3), PARS2(4), QARS(3), RARS(3), RARS2(5), SARS(2), SARS2(4), TARS(4), TARS2(4), VARS(2), VARS2(12), WARS(6), WARS2(1), YARS2(3) 16202126 122 70 122 65 30 33 9 33 15 2 0.996 1.000 1.000 259 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 32 A1BG(7), AKT1(2), AKT2(7), AKT3(4), BTK(1), CDKN2A(3), DAPP1(1), GSK3A(2), GSK3B(6), IARS(9), INPP5D(3), PDK1(1), PIK3CA(10), PPP1R13B(7), RPS6KA1(4), RPS6KA2(6), RPS6KA3(10), RPS6KB1(5), SFN(1), SHC1(5), SOS1(10), SOS2(8), TEC(2), YWHAB(2), YWHAE(2), YWHAG(2), YWHAH(1), YWHAZ(1) 10458557 122 70 121 39 24 32 20 32 13 1 0.244 1.000 1.000 260 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(4), ADH1A(2), ADH1B(6), ADH6(2), ADH7(3), ADHFE1(1), ALDH1A3(2), ALDH3A1(3), ALDH3B1(5), ALDH3B2(4), AOC2(3), AOC3(3), AOX1(10), COMT(1), DBH(2), DCT(5), DDC(4), FAH(1), GOT1(2), GOT2(2), GSTZ1(2), HGD(2), HPD(3), MAOA(4), MAOB(3), TAT(1), TH(3), TPO(11), TYR(6) 9503672 100 70 98 51 20 19 10 32 18 1 0.994 1.000 1.000 261 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(6), DIAPH1(6), FYN(2), GSN(2), ITGA1(7), ITGB1(3), MAP2K1(5), MAPK1(3), MAPK3(1), MYLK(4), PIK3CA(10), PIK3R1(5), PTK2(9), PXN(5), RAF1(2), ROCK1(7), SHC1(5), SRC(2), TLN1(12) 11328089 96 69 95 29 13 31 10 25 17 0 0.417 1.000 1.000 262 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(15), ATR(14), BRCA1(11), CCNB1(4), CDC25A(2), CDC25B(4), CDC25C(1), CDC34(1), CDKN1A(6), CHEK1(7), CHEK2(6), EP300(7), GADD45A(1), MDM2(2), MYT1(6), PRKDC(26), RPS6KA1(4), WEE1(4), YWHAH(1) 12698749 122 69 120 49 22 22 11 46 19 2 0.874 1.000 1.000 263 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 25 AKT1(2), APC(12), AXIN1(14), CCND1(1), DVL1(1), FZD1(1), GJA1(4), GNAI1(4), GSK3B(6), IRAK1(6), LBP(5), LEF1(4), LY96(1), MYD88(3), NFKB1(7), PDPK1(2), PIK3CA(10), PIK3R1(5), PPP2CA(4), RELA(4), TIRAP(2), TLR4(3), TOLLIP(1), WNT1(3) 8848253 105 69 104 47 16 21 14 29 24 1 0.962 1.000 1.000 264 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(2), ACAA2(2), ACADL(6), ACADM(1), ACADS(3), ACADSB(1), ACADVL(3), ACAT1(1), ACAT2(6), ACOX1(6), ACOX3(7), ACSL1(3), ACSL3(3), ACSL4(2), ACSL5(3), ACSL6(2), ADH1A(2), ADH1B(6), ADH5(1), ADH6(2), ADH7(3), ADHFE1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH7A1(2), ALDH9A1(2), CPT1A(6), CPT1B(4), CPT1C(3), CPT2(1), CYP4A11(5), CYP4A22(4), ECHS1(2), EHHADH(14), GCDH(2), HADH(1), HADHA(3), HADHB(2), HSD17B4(8) 14662437 135 69 132 74 24 27 18 47 19 0 0.998 1.000 1.000 265 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 27 ADRBK1(5), AKT1(2), AKT2(7), AKT3(4), ITPKA(1), ITPKB(2), ITPR1(18), ITPR2(19), ITPR3(15), NFKB1(7), NFKB2(2), NFKBIA(2), NFKBIE(1), NFKBIL1(3), PDK1(1), PHKA2(5), PIK3CB(12), PITX2(1), PLD1(6), PLD2(5), PLD3(5), VN1R1(3) 13928629 126 69 124 49 36 25 9 40 15 1 0.918 1.000 1.000 266 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(10), BAX(1), BCL2(1), BID(2), BIRC2(6), BIRC3(6), CASP2(1), CASP3(2), CASP6(2), CASP7(4), CASP8(3), CASP9(1), FADD(2), FAS(5), FASLG(2), GZMB(1), JUN(1), MAP2K4(4), MAP3K1(6), MAP3K14(2), MAPK10(4), MCL1(2), MDM2(2), MYC(2), NFKB1(7), NFKBIA(2), PARP1(4), PRF1(4), RELA(4), RIPK1(6), TNF(2), TNFRSF1A(2), TNFRSF1B(3), TNFSF10(2), TRAF1(3) 11081838 111 68 110 42 21 26 9 33 22 0 0.865 1.000 1.000 267 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), AKR1B10(1), B4GALT2(2), G6PC(4), G6PC2(4), GAA(2), GALK1(3), GALK2(1), GALT(1), GANC(3), GCK(3), GLA(1), GLB1(6), HK1(4), HK2(8), HK3(6), HSD3B7(2), LALBA(1), LCT(7), MGAM(18), PFKL(3), PFKM(2), PFKP(6), PGM1(3), PGM3(6), RDH11(2), RDH12(2), RDH13(1), UGP2(2) 11581293 106 68 105 54 27 22 16 27 14 0 0.986 1.000 1.000 268 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(2), ARSD(5), ARSE(2), ASAH1(4), B4GALT6(5), CERK(2), DEGS1(2), DEGS2(1), ENPP7(3), GALC(6), GBA(1), GLA(1), GLB1(6), LCT(7), NEU1(5), NEU2(3), NEU3(2), NEU4(3), PPAP2A(3), PPAP2B(1), PPAP2C(4), SGMS1(2), SGMS2(1), SGPP1(1), SGPP2(1), SMPD1(3), SMPD2(2), SMPD3(1), SMPD4(4), SPHK1(6), SPHK2(4), SPTLC1(2), SPTLC2(4), UGCG(2), UGT8(1) 10679376 102 68 101 51 26 25 15 28 8 0 0.977 1.000 1.000 269 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(7), ADRBK2(4), ARRB2(2), CALM1(1), CALML6(1), CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), CLCA1(9), CLCA2(10), CLCA4(6), CNGA3(8), CNGA4(3), CNGB1(6), GNAL(4), GUCA1B(2), GUCA1C(2), PDC(1), PDE1C(11), PRKACA(2), PRKACB(3), PRKACG(1), PRKG1(5), PRKG2(11), PRKX(4) 9345154 116 68 116 43 30 25 12 33 13 3 0.792 1.000 1.000 270 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(1), CAMK1G(3), FPR1(2), GNA15(2), GNB1(4), GNGT1(1), MAP2K1(5), MAP2K2(3), MAP2K6(1), MAP3K1(6), MAPK1(3), MAPK14(4), MAPK3(1), NCF2(4), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), NFKB1(7), NFKBIA(2), PAK1(4), PIK3C2G(11), PLCB1(11), PPP3CA(6), PPP3CB(5), PPP3CC(1), RAC1(1), RAF1(2), RELA(4), SYT1(1) 11727242 111 67 111 56 22 30 13 30 16 0 0.996 1.000 1.000 271 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(15), ATR(14), BRCA1(11), BRCA2(20), CHEK1(7), CHEK2(6), FANCA(20), FANCC(2), FANCD2(12), FANCE(2), FANCF(1), FANCG(2), HUS1(2), MRE11A(3), RAD1(2), RAD17(2), RAD50(4), RAD51(5), RAD9A(2), TREX1(2) 12889059 134 66 131 48 31 29 15 38 19 2 0.553 1.000 1.000 272 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), AKR1B10(1), ALDOB(3), FBP1(2), FBP2(1), FPGT(4), FUK(4), GMDS(2), GMPPA(5), GMPPB(2), HK1(4), HK2(8), HK3(6), HSD3B7(2), KHK(1), LHPP(1), MPI(2), MTMR1(2), MTMR2(3), MTMR6(5), PFKFB1(4), PFKFB2(2), PFKFB3(5), PFKFB4(3), PFKL(3), PFKM(2), PFKP(6), PGM2(7), PHPT1(1), PMM1(3), PMM2(1), RDH11(2), RDH12(2), RDH13(1), SORD(4), TSTA3(1) 11343325 107 66 107 49 23 26 17 26 15 0 0.969 1.000 1.000 273 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(4), ALDH1A3(2), ALDH3A1(3), ALDH3B1(5), ALDH3B2(4), AOC2(3), AOC3(3), DDC(4), EPX(8), ESCO1(4), ESCO2(5), GOT1(2), GOT2(2), HPD(3), LPO(8), MAOA(4), MAOB(3), MPO(11), NAT6(2), PNPLA3(3), PRDX6(1), SH3GLB1(2), TAT(1), TPO(11) 10162320 98 66 96 32 21 17 15 31 13 1 0.373 1.000 1.000 274 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(10), POLA2(1), POLB(4), POLD1(5), POLD3(1), POLE(9), POLE2(7), POLE3(2), POLG(7), POLG2(2), POLH(2), POLI(5), POLK(3), POLL(1), POLQ(18), PRIM1(2), PRIM2(2), REV1(11), REV3L(16), RFC5(3) 12430872 111 66 109 44 29 33 6 27 15 1 0.719 1.000 1.000 275 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(1), ACTG2(1), ADCY3(7), ADCY9(9), ARF1(2), ARF3(1), ARF4(1), ARF5(3), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(1), ATP6V0D2(3), ATP6V1A(3), ATP6V1C1(1), ATP6V1C2(3), ATP6V1D(2), ATP6V1E2(1), ATP6V1F(2), ATP6V1G3(1), ATP6V1H(2), ERO1L(1), GNAS(9), PDIA4(1), PLCG1(10), PLCG2(16), PRKCA(2), SEC61A1(3), SEC61G(1), TRIM23(3) 11187942 105 66 103 42 32 25 9 22 17 0 0.945 1.000 1.000 276 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(1), BCR(4), BLNK(3), FOS(2), JUN(1), LYN(3), MAP2K1(5), MAP3K1(6), MAPK1(3), MAPK3(1), MAPK8IP3(2), PAPPA(9), RAC1(1), RPS6KA1(4), RPS6KA3(10), SHC1(5), SOS1(10), SYK(4), VAV1(6), VAV2(2), VAV3(7) 9625454 89 66 89 34 18 22 16 24 8 1 0.657 1.000 1.000 277 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(2), AGTR1(3), ATF2(1), CALM1(1), EGFR(7), JUN(1), MAP2K1(5), MAP2K2(3), MAP2K4(4), MAP3K1(6), MAPK1(3), MAPK3(1), MEF2A(4), MEF2C(3), MEF2D(1), PAK1(4), PRKCA(2), PTK2(9), PTK2B(8), RAC1(1), RAF1(2), SHC1(5), SOS1(10), SRC(2), SYT1(1) 10276822 89 65 89 38 20 25 8 20 15 1 0.943 1.000 1.000 278 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ACYP2(1), ADH1A(2), ADH1B(6), ADH6(2), ADH7(3), ADHFE1(1), AKR1A1(3), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(5), ALDH3B2(4), ALDH9A1(2), ALDOB(3), DLAT(4), DLD(2), ENO1(2), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(4), GCK(3), GPI(2), HK1(4), HK2(8), HK3(6), LDHA(1), LDHB(2), LDHC(2), PDHA1(1), PDHA2(4), PDHB(2), PFKM(2), PFKP(6), PGAM1(1), PGK1(2), PGM1(3), PGM3(6), PKLR(1) 14614061 120 65 118 83 36 23 10 25 25 1 1.000 1.000 1.000 279 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ACYP2(1), ADH1A(2), ADH1B(6), ADH6(2), ADH7(3), ADHFE1(1), AKR1A1(3), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(5), ALDH3B2(4), ALDH9A1(2), ALDOB(3), DLAT(4), DLD(2), ENO1(2), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(4), GCK(3), GPI(2), HK1(4), HK2(8), HK3(6), LDHA(1), LDHB(2), LDHC(2), PDHA1(1), PDHA2(4), PDHB(2), PFKM(2), PFKP(6), PGAM1(1), PGK1(2), PGM1(3), PGM3(6), PKLR(1) 14614061 120 65 118 83 36 23 10 25 25 1 1.000 1.000 1.000 280 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(5), AARS2(7), ABAT(3), ACY3(2), ADSL(1), ADSS(3), ADSSL1(2), AGXT(5), AGXT2(3), ASL(2), ASNS(6), ASPA(1), ASRGL1(2), ASS1(2), CAD(7), CRAT(3), DARS(1), DDO(2), DLAT(4), DLD(2), GAD1(5), GAD2(2), GOT1(2), GOT2(2), GPT(5), GPT2(3), NARS2(3), PC(10), PDHA1(1), PDHA2(4), PDHB(2) 11405815 102 65 102 54 27 28 11 29 7 0 0.994 1.000 1.000 281 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(3), ACACA(10), ACACB(14), ACADM(1), ACAT1(1), ACAT2(6), ACSS1(2), ACSS2(3), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH6A1(6), ALDH7A1(2), ALDH9A1(2), ECHS1(2), EHHADH(14), HADHA(3), HIBCH(5), LDHA(1), LDHAL6A(2), LDHAL6B(7), LDHB(2), LDHC(2), MUT(4), PCCA(3), PCCB(5), SUCLA2(3), SUCLG1(2), SUCLG2(2) 11878078 117 65 116 65 25 30 18 31 13 0 0.991 1.000 1.000 282 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(2), AADAC(3), ABAT(3), ACADS(3), ACAT1(1), ACAT2(6), ACSM1(5), AKR1B10(1), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH7A1(2), ALDH9A1(2), BDH1(1), BDH2(3), DDHD1(5), ECHS1(2), EHHADH(14), GAD1(5), GAD2(2), HADH(1), HADHA(3), HMGCL(1), HMGCS1(4), HMGCS2(3), HSD17B4(8), HSD3B7(2), ILVBL(1), L2HGDH(2), OXCT1(7), PDHA1(1), PDHA2(4), PDHB(2), PLA1A(3), PPME1(2), PRDX6(1), RDH11(2), RDH12(2), RDH13(1) 12338995 120 65 119 64 30 25 16 38 11 0 0.993 1.000 1.000 283 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 40 ALAD(2), ALAS1(2), ALAS2(3), BLVRA(2), COX10(3), COX15(3), CP(6), CPOX(3), EARS2(1), EPRS(7), FECH(2), FTMT(2), GUSB(6), HCCS(2), HMBS(3), HMOX1(1), HMOX2(2), MMAB(1), PPOX(3), UGT1A1(1), UGT1A10(3), UGT1A3(2), UGT1A4(1), UGT1A5(13), UGT1A8(1), UGT1A9(1), UGT2A1(5), UGT2A3(3), UGT2B10(2), UGT2B11(3), UGT2B15(5), UGT2B17(1), UGT2B4(5), UGT2B7(5), UROS(3) 11882431 108 65 106 63 18 19 11 37 22 1 1.000 1.000 1.000 284 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(1), ALOX12(1), ALOX15(3), ALOX5(4), CBR3(2), CYP4F2(3), CYP4F3(1), EPX(8), LPO(8), LTA4H(5), MPO(11), PLA2G1B(1), PLA2G2A(1), PLA2G2E(1), PLA2G3(4), PLA2G4A(6), PLA2G6(6), PRDX1(1), PRDX2(2), PRDX5(3), PRDX6(1), PTGES2(2), PTGIS(2), PTGS1(3), PTGS2(2), TBXAS1(2), TPO(11) 8523085 95 65 95 45 22 17 15 27 14 0 0.977 1.000 1.000 285 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(2), ACTR3(3), ARHGAP1(1), ARHGAP4(1), ARHGAP5(6), ARHGAP6(3), ARHGEF1(3), ARHGEF11(5), ARHGEF5(4), ARPC1A(2), ARPC1B(2), ARPC2(5), ARPC4(2), BAIAP2(3), CFL1(3), DIAPH1(6), GSN(2), LIMK1(2), MYLK(4), OPHN1(4), PIP5K1B(2), PPP1R12B(5), ROCK1(7), SRC(2), TLN1(12), VCL(4) 14402231 95 65 95 47 20 23 7 23 22 0 0.998 1.000 1.000 286 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(2), BRAF(2), CREB1(1), CREB3(2), CREB5(5), DUSP6(3), DUSP9(2), EEF2K(5), EIF4E(2), MAP2K1(5), MAP2K2(3), MAP3K8(2), MAPK1(3), MAPK3(1), MKNK1(2), MKNK2(1), MOS(1), NFKB1(7), RAP1A(2), RPS6KA1(4), RPS6KA2(6), RPS6KA3(10), SHC1(5), SOS1(10), SOS2(8), TRAF3(1) 8966629 95 65 95 33 28 22 14 23 7 1 0.435 1.000 1.000 287 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(2), ATF2(1), CDC42(2), DLD(2), DUSP8(1), GAB1(5), GADD45A(1), GCK(3), IL1R1(4), JUN(1), MAP2K4(4), MAP2K5(1), MAP2K7(2), MAP3K1(6), MAP3K10(1), MAP3K11(3), MAP3K12(2), MAP3K13(3), MAP3K2(1), MAP3K3(2), MAP3K4(9), MAP3K5(6), MAP3K7(3), MAP3K9(5), MAPK10(4), MAPK7(6), MAPK9(4), MYEF2(4), NFATC3(4), NR2C2(4), PAPPA(9), SHC1(5), TRAF6(1), ZAK(7) 14768628 118 65 118 65 18 28 17 35 19 1 0.999 1.000 1.000 288 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 32 CHUK(9), FOS(2), IKBKB(6), IRAK1(6), JUN(1), LY96(1), MAP2K4(4), MAP2K6(1), MAP3K1(6), MAP3K14(2), MAP3K7(3), MAPK14(4), MYD88(3), NFKB1(7), NFKBIA(2), PPARA(4), RELA(4), TIRAP(2), TLR10(6), TLR2(2), TLR3(4), TLR4(3), TLR6(6), TLR7(7), TLR9(3), TOLLIP(1), TRAF6(1) 11182813 100 65 99 52 17 24 13 28 18 0 0.998 1.000 1.000 289 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(2), ACAA2(2), ACADL(6), ACADM(1), ACADS(3), ACADSB(1), ACAT1(1), ACAT2(6), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH6A1(6), ALDH9A1(2), AOX1(10), BCAT1(5), BCKDHA(4), BCKDHB(2), ECHS1(2), EHHADH(14), HADHA(3), HADHB(2), HIBADH(1), HMGCL(1), IVD(2), MCCC1(4), MCCC2(1), MUT(4), OXCT1(7), PCCA(3), PCCB(5), SDS(4) 10914097 118 65 117 53 23 31 14 29 21 0 0.872 1.000 1.000 290 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(7), CALM1(1), CREB1(1), FOS(2), GNAI1(4), GNAS(9), GNB1(4), GNGT1(1), JUN(1), MAP2K1(5), MAPK3(1), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), PLCG1(10), PPP3CA(6), PPP3CB(5), PPP3CC(1), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(2), RAF1(2), RPS6KA3(10), SYT1(1) 10364483 98 64 96 33 19 25 11 26 16 1 0.659 1.000 1.000 291 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(3), ADC(1), ALDH4A1(4), CAD(7), CPS1(10), EARS2(1), EPRS(7), GAD1(5), GAD2(2), GCLM(1), GFPT1(2), GFPT2(2), GLS(4), GLS2(3), GLUD1(3), GLUD2(3), GLUL(3), GMPS(3), GNPNAT1(2), GOT1(2), GOT2(2), GPT(5), GPT2(3), GSR(3), GSS(4), NADSYN1(4), NAGK(3), PPAT(3), QARS(3) 11824743 98 64 98 48 25 25 8 27 12 1 0.987 1.000 1.000 292 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(4), ACY3(2), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(5), ALDH3B2(4), ALDH7A1(2), ALDH9A1(2), AMDHD1(4), AOC2(3), AOC3(3), ASPA(1), CARM1(2), CNDP1(2), DDC(4), FTCD(5), HAL(2), HARS(1), HARS2(3), HDC(5), HEMK1(5), LCMT1(2), LCMT2(4), MAOA(4), MAOB(3), METTL2B(6), METTL6(1), PRMT3(2), PRMT5(4), PRMT6(4), PRMT7(1), PRMT8(3), PRPS1(1), PRPS2(3), UROC1(4), WBSCR22(1) 11909085 112 64 110 47 29 16 15 35 14 3 0.916 1.000 1.000 293 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(2), ATF1(2), CDC42(2), CREB1(1), CREB3(2), CREB5(5), DUSP1(1), EEF2K(5), EIF4E(2), GADD45A(1), IL1R1(4), MAP2K4(4), MAP2K6(1), MAP3K10(1), MAP3K4(9), MAP3K5(6), MAP3K7(3), MAPK1(3), MAPK11(4), MAPK12(2), MAPK13(1), MAPK14(4), MAPKAPK2(4), MAPKAPK5(4), MKNK1(2), MKNK2(1), MYEF2(4), NFKB1(7), NR2C2(4), SRF(1), TRAF6(1) 10273418 93 64 90 38 23 22 11 22 14 1 0.873 1.000 1.000 294 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(10), BCL2(1), BID(2), BIRC2(6), BIRC3(6), CASP10(4), CASP3(2), CASP6(2), CASP7(4), CASP8(3), CASP9(1), CFLAR(2), CHUK(9), DFFA(2), DFFB(3), FADD(2), GAS2(1), LMNA(3), MAP3K14(2), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(6), SPTAN1(9), TNFRSF10A(4), TNFRSF10B(2), TNFRSF25(3), TNFSF10(2) 10057912 104 63 104 40 19 24 9 31 21 0 0.869 1.000 1.000 295 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), B4GALT2(2), FBP2(1), G6PC(4), GAA(2), GALK1(3), GALK2(1), GALT(1), GANAB(5), GCK(3), GLA(1), GLB1(6), HK1(4), HK2(8), HK3(6), LALBA(1), LCT(7), MGAM(18), PFKM(2), PFKP(6), PGM1(3), PGM3(6) 9784352 92 63 91 49 25 20 16 21 10 0 0.985 1.000 1.000 296 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(11), ATP4B(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(3), ATP6V1D(2), ATP6V1F(2), ATP6V1G3(1), ATP6V1H(2), ATP7A(9), ATP7B(8), COX10(3), COX4I1(1), COX5A(2), COX5B(2), COX6A1(1), COX6B1(1), NDUFA1(1), NDUFA10(5), NDUFA5(2), NDUFA8(1), NDUFB5(1), NDUFB7(1), NDUFS1(3), NDUFS2(1), NDUFV2(2), PPA2(4), SDHA(5), SDHB(3), SHMT1(4), UQCRB(1), UQCRFS1(2), UQCRH(1) 11515534 111 63 107 48 28 24 14 33 12 0 0.908 1.000 1.000 297 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(3), BTK(1), CALM1(1), CD79A(1), FOS(2), JUN(1), LYN(3), MAP2K1(5), MAP3K1(6), MAPK14(4), MAPK3(1), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), PLCG1(10), PPP3CA(6), PPP3CB(5), PPP3CC(1), PRKCA(2), RAC1(1), RAF1(2), SHC1(5), SOS1(10), SYK(4), SYT1(1), VAV1(6) 11296590 97 62 97 42 23 27 13 23 10 1 0.875 1.000 1.000 298 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 31 ADRA1A(3), ADRA1B(2), ADRA1D(3), ADRA2A(1), ADRA2C(1), ADRB1(1), ADRB2(5), ADRB3(1), CHRM2(5), CHRM3(4), CHRM4(1), CHRM5(3), DRD2(2), DRD3(5), DRD5(8), HRH1(1), HRH2(3), HTR1A(1), HTR1B(1), HTR1D(2), HTR1E(2), HTR1F(3), HTR2A(2), HTR2B(4), HTR2C(7), HTR4(1), HTR5A(1), HTR6(4), HTR7(10) 7598955 87 62 79 38 28 15 6 30 8 0 0.930 1.000 1.000 299 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(1), CDC42(2), CREB1(1), DAXX(1), DDIT3(1), HMGN1(1), HSPB2(4), MAP2K4(4), MAP2K6(1), MAP3K1(6), MAP3K5(6), MAP3K7(3), MAP3K9(5), MAPK14(4), MAPKAPK2(4), MAPKAPK5(4), MEF2A(4), MEF2C(3), MEF2D(1), MKNK1(2), MYC(2), PLA2G4A(6), RAC1(1), RIPK1(6), RPS6KA5(3), SHC1(5), STAT1(7), TGFB1(1), TGFB2(4), TGFB3(3), TGFBR1(5) 11259626 101 62 99 46 15 24 19 28 15 0 0.965 1.000 1.000 300 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), ITPKA(1), ITPKB(2), ITPR1(18), ITPR2(19), ITPR3(15), NFAT5(13), PDE6A(7), PDE6B(7), PDE6C(5), SLC6A13(3), TF(3) 10960521 106 62 105 53 32 25 4 31 13 1 0.997 1.000 1.000 301 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG10B(3), ALG11(2), ALG12(1), ALG13(9), ALG2(6), ALG3(1), ALG5(1), ALG6(5), ALG8(1), ALG9(4), B4GALT2(2), B4GALT3(2), DDOST(1), DHDDS(1), DOLPP1(1), DPAGT1(3), DPM1(1), FUT8(2), GANAB(5), MAN1A1(3), MAN1A2(4), MAN1B1(1), MAN1C1(5), MAN2A1(7), MGAT1(3), MGAT2(2), MGAT3(8), MGAT4A(2), MGAT5(5), MGAT5B(5), RFT1(3), RPN1(2), RPN2(2), ST6GAL1(2), STT3B(3) 12853827 109 61 108 54 27 23 14 25 18 2 0.977 1.000 1.000 302 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 38 ANAPC1(3), ANAPC10(1), ANAPC2(4), ANAPC4(1), ANAPC5(6), ANAPC7(3), BTRC(6), CDC16(4), CDC20(1), CDC23(3), CUL1(3), CUL2(5), CUL3(7), FBXW11(8), FBXW7(3), FZR1(4), ITCH(2), SKP2(3), SMURF1(4), SMURF2(3), TCEB2(1), UBA1(7), UBE2C(1), UBE2D1(1), UBE2D2(2), UBE2D3(2), UBE2E1(3), VHL(1), WWP1(6), WWP2(3) 12009542 101 61 100 70 21 25 9 24 22 0 1.000 1.000 1.000 303 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(4), ALDH1A3(2), ALDH3A1(3), ALDH3B1(5), ALDH3B2(4), AOC2(3), AOC3(3), DDC(4), EPX(8), GOT1(2), GOT2(2), HPD(3), LPO(8), MAOA(4), MAOB(3), MPO(11), PRDX1(1), PRDX2(2), PRDX5(3), PRDX6(1), TAT(1), TPO(11) 6612574 88 61 86 28 18 15 13 27 14 1 0.438 1.000 1.000 304 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(8), EGF(10), EGFR(7), MAP2K1(5), MAPK1(3), MAPK3(1), PTPRB(14), RAF1(2), RASA1(10), SHC1(5), SOS1(10), SPRY1(1), SPRY2(2), SPRY3(2), SPRY4(1), SRC(2) 7528603 83 61 83 33 18 22 7 21 14 1 0.821 1.000 1.000 305 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 38 ARNTL(3), BTG1(1), CBX3(3), CLDN5(1), CLOCK(4), CRY1(5), DNAJA1(2), EIF4G2(6), ETV6(2), GFRA1(3), GSTM3(1), GSTP1(4), HSPA8(1), IDI1(2), KLF9(2), MYF6(1), NCKAP1(6), NCOA4(4), PER1(4), PER2(7), PIGF(3), PPP1R3C(2), PPP2CB(3), PSMA4(3), SF3A3(4), TOB1(2), TUBB3(1), UCP3(2), UGP2(2), VAPA(1), ZFR(4) 10623163 89 60 86 45 17 30 6 18 18 0 0.970 1.000 1.000 306 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 29 AKT1(2), CABIN1(8), CALM1(1), CAMK1G(3), HDAC5(3), IGF1(1), IGF1R(12), INSR(11), MAP2K6(1), MAPK14(4), MAPK7(6), MEF2A(4), MEF2C(3), MEF2D(1), MYOD1(3), NFATC1(3), NFATC2(4), PIK3CA(10), PIK3R1(5), PPP3CA(6), PPP3CB(5), PPP3CC(1), SYT1(1), YWHAH(1) 10400627 99 60 98 31 22 17 16 31 13 0 0.459 1.000 1.000 307 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(9), IFNB1(1), IKBKB(6), IL1A(3), IL1B(2), IL1R1(4), IL1RAP(4), IL6(3), IRAK1(6), IRAK2(3), IRAK3(4), JUN(1), MAP2K6(1), MAP3K1(6), MAP3K14(2), MAP3K7(3), MAPK14(4), MYD88(3), NFKB1(7), NFKBIA(2), RELA(4), TGFB1(1), TGFB2(4), TGFB3(3), TNF(2), TOLLIP(1), TRAF6(1) 8916246 90 60 90 39 14 20 13 29 14 0 0.939 1.000 1.000 308 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(1), CREBBP(12), EP300(7), FYN(2), IL2RG(1), IL7(2), IL7R(10), JAK1(8), JAK3(5), LCK(5), NMI(4), PIK3CA(10), PIK3R1(5), PTK2B(8), STAT5A(2), STAT5B(3) 8451988 85 60 82 36 15 19 10 23 18 0 0.954 1.000 1.000 309 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(2), CAPN1(3), CAPN2(1), CAPNS1(1), CXCR3(1), EGF(10), EGFR(7), ITGA1(7), ITGB1(3), MAPK1(3), MAPK3(1), MYLK(4), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PTK2(9), PXN(5), TLN1(12) 10073893 78 60 78 29 13 27 4 17 16 1 0.818 1.000 1.000 310 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(10), ACAT1(1), ACAT2(6), ACYP1(1), ACYP2(1), ADH5(1), AKR1B1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(2), DLAT(4), DLD(2), GLO1(5), HAGH(2), HAGHL(2), LDHA(1), LDHB(2), LDHC(2), LDHD(1), MDH1(1), MDH2(2), ME1(1), ME2(5), ME3(1), PC(10), PCK1(6), PDHA1(1), PDHA2(4), PDHB(2), PKLR(1) 10969880 93 60 92 62 22 17 18 22 14 0 1.000 1.000 1.000 311 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(5), ACP2(1), ACP5(2), ACPP(5), ACPT(1), ALPI(1), ALPL(3), ALPP(6), ALPPL2(3), CYP19A1(4), CYP1A1(4), CYP2A13(4), CYP2A6(6), CYP2A7(12), CYP2B6(4), CYP2C18(4), CYP2C8(3), CYP2C9(4), CYP2D6(3), CYP2E1(2), CYP2F1(3), CYP2J2(4), CYP3A4(1), CYP3A5(4), CYP3A7(6), CYP4B1(6), CYP4F8(1), CYP51A1(2), PON1(2) 8925210 106 59 102 36 27 21 13 25 20 0 0.719 1.000 1.000 312 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(2), ACAA2(2), ACAD8(2), ACAD9(4), ADH1A(2), ADH1B(6), ADH5(1), ADH6(2), ADH7(3), ADHFE1(1), AKR1B10(1), AKR1C4(3), AKR1D1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH7A1(2), ALDH9A1(2), BAAT(2), CEL(2), CYP27A1(4), CYP7A1(3), HADHB(2), HSD3B7(2), LIPA(5), RDH11(2), RDH12(2), RDH13(1), SLC27A5(7), SOAT1(3), SOAT2(2) 9556555 83 59 82 46 19 23 8 20 13 0 0.993 1.000 1.000 313 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 13 APC(12), AXIN1(14), CREBBP(12), DVL1(1), EP300(7), FZD1(1), GSK3B(6), LDB1(1), LEF1(4), PITX2(1), TRRAP(19), WNT1(3) 9371936 81 59 81 42 10 23 7 20 20 1 0.993 1.000 1.000 314 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 33 GTF2A1(3), GTF2B(7), GTF2E1(3), GTF2E2(2), GTF2F1(1), GTF2H3(1), GTF2I(3), GTF2IRD1(3), STON1(5), TAF1(12), TAF10(1), TAF1L(9), TAF2(11), TAF4(1), TAF4B(4), TAF5(3), TAF5L(3), TAF6(2), TAF6L(1), TAF7(1), TAF7L(6), TAF9B(1), TBPL1(5), TBPL2(1) 11199812 89 58 86 50 15 29 15 17 11 2 0.983 1.000 1.000 315 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(15), BMPR1B(2), CCND2(1), CDKN1B(2), DAZL(1), DMC1(1), ESR2(3), FSHR(2), INHA(2), LHCGR(7), MLH1(4), MSH5(9), NCOR1(11), NR5A1(2), NRIP1(4), PGR(8), PTGER2(5), SMPD1(3), VDR(2), ZP2(3) 10279462 87 58 86 51 22 18 9 24 13 1 0.997 1.000 1.000 316 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(2), CDK5(1), CDK5R1(1), CFL1(3), LIMK1(2), MAP3K1(6), MYLK(4), NCF2(4), PAK1(4), PDGFRA(10), PIK3CA(10), PIK3R1(5), PLD1(6), PPP1R12B(5), RAC1(1), RALBP1(1), RPS6KB1(5), TRIO(12), VAV1(6), WASF1(2) 10535736 90 58 89 40 26 24 7 19 14 0 0.919 1.000 1.000 317 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(2), ABAT(3), ACADS(3), ACAT1(1), ACAT2(6), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(2), ECHS1(2), EHHADH(14), GAD1(5), GAD2(2), HADHA(3), HMGCL(1), L2HGDH(2), OXCT1(7), PDHA1(1), PDHA2(4), PDHB(2), SDHB(3), SDS(4) 7718308 81 57 80 49 20 15 12 26 8 0 0.998 1.000 1.000 318 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(2), APAF1(10), ATM(15), BAX(1), BCL2(1), BID(2), CASP3(2), CASP6(2), CASP7(4), CASP9(1), EIF2S1(1), PRKCA(2), PTK2(9), PXN(5), STAT1(7), TLN1(12) 7887244 76 57 76 26 17 19 7 24 9 0 0.512 1.000 1.000 319 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 29 B4GALT5(2), C1GALT1C1(1), GALNT1(4), GALNT11(3), GALNT12(3), GALNT13(7), GALNT14(3), GALNT3(3), GALNT4(7), GALNT5(6), GALNT6(4), GALNT8(6), GALNT9(3), GALNTL5(4), GCNT3(4), GCNT4(2), OGT(4), ST3GAL1(1), ST6GALNAC1(6), WBSCR17(7) 9624920 80 57 77 31 14 20 15 23 8 0 0.677 1.000 1.000 320 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(9), CREBBP(12), DUSP1(1), EP300(7), IKBKB(6), IL1B(2), MAP2K6(1), MAP3K14(2), MAP3K7(3), MAPK11(4), MAPK14(4), MYD88(3), NFKB1(7), NFKBIA(2), NR3C1(4), RELA(4), TGFBR1(5), TGFBR2(1), TLR2(2), TNF(2) 8894036 81 57 80 38 14 21 10 23 13 0 0.973 1.000 1.000 321 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(3), CALM1(1), JUN(1), MAP2K1(5), MAP2K2(3), MAP2K4(4), MAP3K1(6), MAPK1(3), MAPK14(4), MAPK3(1), PAK1(4), PLCG1(10), PRKCA(2), PTK2B(8), RAC1(1), RAF1(2), SHC1(5), SOS1(10), SRC(2), SYT1(1) 8523583 76 57 76 30 19 21 8 12 15 1 0.895 1.000 1.000 322 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(12), AXIN1(14), BTRC(6), CCND1(1), CREBBP(12), CSNK1A1(1), CSNK2A1(2), CTBP1(2), DVL1(1), FZD1(1), GSK3B(6), MAP3K7(3), MYC(2), NLK(3), PPARD(1), PPP2CA(4), TLE1(6), WIF1(5), WNT1(3) 8508551 85 57 85 40 13 25 4 18 23 2 0.981 1.000 1.000 323 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(3), ALDH4A1(4), CAD(7), CPS1(10), EPRS(7), GAD1(5), GAD2(2), GCLM(1), GFPT1(2), GLS(4), GLS2(3), GLUD1(3), GLUL(3), GMPS(3), GOT1(2), GOT2(2), GPT(5), GPT2(3), GSS(4), NADSYN1(4), PPAT(3), QARS(3) 9994593 83 56 83 43 23 22 5 21 11 1 0.991 1.000 1.000 324 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(19), APOA4(3), APOC2(1), APOC3(1), CETP(2), CYP7A1(3), DGAT1(2), HMGCR(5), LCAT(3), LDLR(5), LIPC(6), LPL(4), LRP1(19), SCARB1(2), SOAT1(3) 8102603 78 56 76 32 21 19 10 22 4 2 0.877 1.000 1.000 325 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(2), BCL2(1), BCR(4), FOS(2), JAK2(9), JUN(1), MAP2K1(5), MAP2K4(4), MAP3K1(6), MAPK3(1), MYC(2), PIK3CA(10), PIK3R1(5), RAF1(2), SOS1(10), STAT1(7), STAT5A(2), STAT5B(3) 8320312 76 55 75 21 16 20 9 17 13 1 0.318 1.000 1.000 326 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(3), CALCR(4), CALCRL(1), CD97(5), CRHR1(3), CRHR2(6), ELTD1(9), EMR1(10), EMR2(3), GHRHR(2), GIPR(3), GLP1R(2), GLP2R(6), GPR64(5), LPHN1(10), LPHN2(9), LPHN3(12), SCTR(1), VIPR1(2), VIPR2(4) 8425248 100 55 97 38 12 18 17 35 18 0 0.882 1.000 1.000 327 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 28 BAG4(5), BIRC2(6), BIRC3(6), CASP3(2), CASP8(3), CFLAR(2), FADD(2), JUN(1), MAP2K4(4), MAP3K3(2), MAP3K7(3), NFKB1(7), NFKB2(2), NFKBIA(2), NFKBIE(1), NFKBIL1(3), NR2C2(4), RALBP1(1), RIPK1(6), TNF(2), TNFAIP3(4), TNFRSF1A(2), TNFRSF1B(3) 8466660 73 55 73 28 19 16 6 20 12 0 0.830 1.000 1.000 328 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CHUK(9), EGR2(3), EGR3(5), MAP3K1(6), MYC(2), NFATC1(3), NFATC2(4), NFKB1(7), NFKBIA(2), PLCG1(10), PPP3CA(6), PPP3CB(5), PPP3CC(1), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), RELA(4), SYT1(1), VIP(1), VIPR2(4) 8240184 83 55 83 37 18 21 7 20 15 2 0.966 1.000 1.000 329 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(3), ABP1(4), ACADL(6), ACADM(1), ACADSB(1), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(2), AOC2(3), AOC3(3), CNDP1(2), DPYD(17), ECHS1(2), EHHADH(14), GAD1(5), GAD2(2), HADHA(3), SDS(4), SMS(1), UPB1(1) 8608180 88 54 86 39 12 20 16 29 11 0 0.896 1.000 1.000 330 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(3), ABP1(4), ACADM(1), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH7A1(2), ALDH9A1(2), AOC2(3), AOC3(3), CNDP1(2), DPYD(17), ECHS1(2), EHHADH(14), GAD1(5), GAD2(2), HADHA(3), HIBCH(5), SMS(1), SRM(3), UPB1(1) 8005188 83 54 81 32 11 20 15 29 8 0 0.661 1.000 1.000 331 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(3), AGPAT2(1), AGPAT3(4), AGPAT4(1), AGPAT6(5), AGPS(3), CHPT1(3), ENPP2(7), ENPP6(2), PAFAH1B1(1), PAFAH1B2(3), PAFAH2(1), PLA2G12A(2), PLA2G12B(2), PLA2G1B(1), PLA2G2A(1), PLA2G2D(3), PLA2G2E(1), PLA2G2F(6), PLA2G3(4), PLA2G4A(6), PLA2G6(6), PLD1(6), PLD2(5), PPAP2A(3), PPAP2B(1), PPAP2C(4) 7093959 85 54 85 28 22 18 12 20 13 0 0.443 1.000 1.000 332 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 ARSB(1), FUCA1(2), FUCA2(1), GALNS(3), GBA(1), GLB1(6), GNS(2), GUSB(6), HEXA(2), HEXB(1), HGSNAT(3), HPSE(1), HPSE2(2), HYAL1(2), HYAL2(2), IDUA(4), LCT(7), MAN2B1(2), MAN2B2(7), MAN2C1(10), MANBA(2), NAGLU(4), NEU1(5), NEU2(3), NEU3(2), NEU4(3), SPAM1(5) 10641212 89 54 89 51 23 16 13 28 9 0 0.997 1.000 1.000 333 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(4), CS(1), DLAT(4), DLD(2), DLST(2), FH(4), IDH2(5), IDH3B(1), IDH3G(2), MDH1(1), MDH2(2), OGDH(4), PC(10), PDHA1(1), PDHA2(4), PDHB(2), PDHX(4), PDK1(1), PDK2(2), PDK3(3), PDK4(3), SDHA(5), SDHB(3), SUCLA2(3), SUCLG1(2), SUCLG2(2) 8580258 77 54 77 33 15 15 15 25 7 0 0.821 1.000 1.000 334 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(12), C5(9), C6(2), C7(3), ICAM1(2), IL1A(3), IL6(3), ITGA4(7), ITGAL(7), ITGB1(3), ITGB2(9), SELP(8), SELPLG(3), TNF(2), VCAM1(3) 7439472 76 54 73 45 13 19 12 21 11 0 0.997 1.000 1.000 335 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), DLG4(3), GRIN1(6), GRIN2A(6), GRIN2B(10), GRIN2C(4), GRIN2D(4), NOS1(15), PPP3CA(6), PPP3CB(5), PPP3CC(1), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(2), SYT1(1) 7713544 73 54 73 37 14 19 8 21 10 1 0.993 1.000 1.000 336 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(3), EPHB2(7), F2(2), F2RL1(1), F2RL3(1), JUN(1), MAP2K5(1), MAPK1(3), MAPK7(6), MYEF2(4), PLD1(6), PLD2(5), PLD3(5), PTK2(9), RAF1(2), RASAL1(8), SRC(2), TEC(2), VAV1(6) 8262317 75 54 75 26 18 17 10 24 6 0 0.596 1.000 1.000 337 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CARM1(2), CBS(5), CTH(3), HEMK1(5), LCMT1(2), LCMT2(4), MARS(7), MARS2(1), MAT1A(4), MAT2B(1), METTL2B(6), METTL6(1), PAPSS1(4), PAPSS2(5), PRMT3(2), PRMT5(4), PRMT6(4), PRMT7(1), PRMT8(3), SCLY(4), SEPHS1(2), SEPHS2(1), WBSCR22(1) 7465760 72 53 72 32 20 14 8 22 6 2 0.937 1.000 1.000 338 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 28 AMDHD2(2), CHIA(2), CMAS(2), CTBS(3), CYB5R1(2), CYB5R3(3), GFPT1(2), GFPT2(2), GNE(6), GNPDA2(3), GNPNAT1(2), HEXA(2), HEXB(1), HK1(4), HK2(8), HK3(6), LHPP(1), MTMR1(2), MTMR2(3), MTMR6(5), NAGK(3), NANS(2), NPL(2), PGM3(6), PHPT1(1), UAP1(3) 8383487 78 53 78 42 16 21 9 21 11 0 0.986 1.000 1.000 339 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 22 CHUK(9), FADD(2), IKBKB(6), IL1A(3), IL1R1(4), IRAK1(6), MAP3K1(6), MAP3K14(2), MAP3K7(3), MYD88(3), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(6), TLR4(3), TNF(2), TNFAIP3(4), TNFRSF1A(2), TNFRSF1B(3), TRAF6(1) 7532335 78 53 78 28 16 19 8 25 10 0 0.715 1.000 1.000 340 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(4), GTF2A1(3), GTF2B(7), GTF2E1(3), GTF2F1(1), HDAC3(2), NCOA1(6), NCOA2(10), NCOA3(13), NCOR2(11), POLR2A(10), RARA(2), RXRA(6) 7543692 78 53 77 47 21 15 10 22 10 0 0.998 1.000 1.000 341 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 13 AKT1(2), BCL2(1), EGFR(7), IGF1R(12), MYC(2), POLR2A(10), PPP2CA(4), PRKCA(2), TEP1(15), TERF1(5), TERT(3), TNKS(6), XRCC5(6) 7477864 75 53 75 26 17 18 4 25 11 0 0.739 1.000 1.000 342 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(5), ABAT(3), ADSL(1), ADSS(3), AGXT(5), AGXT2(3), ASL(2), ASNS(6), ASPA(1), CAD(7), CRAT(3), DARS(1), DDO(2), GAD1(5), GAD2(2), GOT1(2), GOT2(2), GPT(5), GPT2(3), PC(10) 7820641 71 52 71 34 18 21 6 21 5 0 0.974 1.000 1.000 343 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(3), AKR1D1(3), ARSB(1), ARSD(5), ARSE(2), CYP11B1(4), CYP11B2(9), HSD11B1(2), HSD17B2(1), HSD17B3(3), HSD3B1(1), STS(3), SULT1E1(1), SULT2A1(3), UGT1A1(1), UGT1A10(3), UGT1A3(2), UGT1A4(1), UGT1A5(13), UGT1A8(1), UGT1A9(1), UGT2B15(5), UGT2B4(5) 8165328 73 52 72 43 12 25 6 20 10 0 0.998 1.000 1.000 344 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 21 F10(3), F13B(2), F2(2), F5(18), F8(11), F9(1), FGA(9), FGB(2), FGG(4), LPA(10), PLAT(2), PLAU(6), PLG(1), SERPINB2(2), SERPINE1(4), SERPINF2(1), VWF(10) 10832946 88 52 84 55 14 28 15 19 12 0 0.999 1.000 1.000 345 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(8), AGT(2), EDN1(2), EDNRA(3), EDNRB(2), EGF(10), EGFR(7), FOS(2), JUN(1), MYC(2), NFKB1(7), PLCG1(10), PRKCA(2), RELA(4) 6099091 62 52 62 25 10 19 8 15 10 0 0.820 1.000 1.000 346 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOB(3), FBP1(2), FBP2(1), FPGT(4), GCK(3), GMDS(2), GMPPA(5), GMPPB(2), HK1(4), HK2(8), HK3(6), KHK(1), MPI(2), PFKFB1(4), PFKFB3(5), PFKFB4(3), PFKM(2), PFKP(6), PMM1(3), PMM2(1), SORD(4) 7291930 73 52 73 30 18 16 13 15 11 0 0.851 1.000 1.000 347 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(3), ACO1(3), ACO2(4), CLYBL(3), CS(1), DLD(2), DLST(2), FH(4), IDH1(7), IDH2(5), IDH3B(1), IDH3G(2), MDH1(1), MDH2(2), OGDH(4), OGDHL(2), PC(10), PCK1(6), SDHA(5), SDHB(3), SUCLA2(3), SUCLG1(2), SUCLG2(2) 8912494 77 52 75 35 10 13 20 26 8 0 0.927 1.000 1.000 348 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(4), ACY1(1), ADC(1), AGMAT(3), ALDH18A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH7A1(2), ALDH9A1(2), AMD1(3), AOC2(3), AOC3(3), ARG1(3), ARG2(2), ASL(2), ASS1(2), CPS1(10), GATM(6), MAOA(4), MAOB(3), NAGS(5), ODC1(3), OTC(3), SMS(1), SRM(3) 8847736 80 52 80 28 20 16 8 27 9 0 0.586 1.000 1.000 349 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(3), ACACA(10), ACADL(6), ACADM(1), ACADSB(1), ACAT1(1), ACAT2(6), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH6A1(6), ALDH9A1(2), ECHS1(2), EHHADH(14), HADHA(3), LDHA(1), LDHB(2), LDHC(2), MUT(4), PCCA(3), PCCB(5), SDS(4), SUCLA2(3), SUCLG1(2), SUCLG2(2) 9926571 97 52 97 57 20 23 14 25 15 0 0.995 1.000 1.000 350 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 37 CCNH(3), CDK7(1), ERCC3(4), GTF2B(7), GTF2E1(3), GTF2E2(2), ILK(1), MNAT1(1), POLR1A(10), POLR1B(3), POLR2A(10), POLR2B(8), POLR2C(1), POLR2E(2), POLR2G(2), POLR2H(1), POLR2I(2), POLR3B(4), POLR3D(3), POLR3E(2), POLR3K(1), TAF5(3), TAF6(2), TAF7(1) 10654172 77 52 77 53 21 17 8 19 12 0 1.000 1.000 1.000 351 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 33 DUSP1(1), GORASP1(1), MAP2K4(4), MAP2K7(2), MAPK1(3), MAPK10(4), MAPK11(4), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(1), MAPK8IP3(2), MAPK9(4), MAPKAPK5(4), NFKB1(7), NFKB2(2), NFKBIA(2), NFKBIE(1), NFKBIL1(3), PIK3CA(10), PIK3CD(5), PIK3R1(5), SYT1(1), TRAF3(1), TRAF5(2), TRAF6(1) 10663947 77 52 75 31 21 15 9 19 13 0 0.934 1.000 1.000 352 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(2), ACTN1(5), ACTN2(8), ACTN3(1), CAPN1(3), CAPNS1(1), ITGA1(7), ITGB1(3), ITGB3(3), PTK2(9), PXN(5), RAC1(1), SPTAN1(9), SRC(2), TLN1(12) 8685170 71 52 71 31 13 23 2 22 11 0 0.974 1.000 1.000 353 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(1), ALOX15(3), ALOX5(4), CYP2C18(4), CYP2C8(3), CYP2C9(4), CYP2E1(2), CYP2J2(4), CYP3A4(1), CYP3A43(3), CYP3A5(4), CYP3A7(6), HSD3B7(2), PLA2G12A(2), PLA2G12B(2), PLA2G1B(1), PLA2G2A(1), PLA2G2D(3), PLA2G2E(1), PLA2G2F(6), PLA2G3(4), PLA2G4A(6), PLA2G6(6), RDH11(2), RDH12(2), RDH13(1) 7322490 78 51 78 25 21 15 12 20 10 0 0.423 1.000 1.000 354 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 25 ATF1(2), CASP2(1), CHUK(9), CRADD(1), IKBKB(6), JUN(1), LTA(2), MAP2K4(4), MAP2K6(1), MAP3K1(6), MAP3K14(2), MAP4K2(4), MAPK14(4), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(6), TANK(2), TNF(2), TNFRSF1A(2) 7492908 68 51 68 27 16 13 8 18 13 0 0.887 1.000 1.000 355 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(2), ARSB(1), ARSD(5), ARSE(2), ASAH1(4), GALC(6), GBA(1), GLA(1), GLB1(6), LCT(7), NEU1(5), NEU2(3), NEU3(2), NEU4(3), PPAP2A(3), PPAP2B(1), PPAP2C(4), SMPD1(3), SMPD2(2), SPTLC1(2), SPTLC2(4), UGCG(2) 7257556 69 50 68 36 15 21 11 18 4 0 0.954 1.000 1.000 356 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG5(3), ATG7(4), BECN1(4), GABARAP(1), GABARAPL1(1), IFNA13(1), IFNA14(2), IFNA16(2), IFNA17(6), IFNA2(2), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(5), IFNA8(2), IFNG(3), PIK3C3(2), PIK3R4(9), PRKAA1(4), PRKAA2(4), ULK1(8), ULK2(8) 6470076 77 50 75 32 16 12 6 30 12 1 0.923 1.000 1.000 357 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 19 CSNK2A1(2), FOS(2), IL6(3), IL6R(1), JAK1(8), JAK2(9), JAK3(5), JUN(1), MAP2K1(5), MAPK3(1), PTPN11(2), RAF1(2), SHC1(5), SOS1(10), SRF(1), STAT3(5) 6629635 62 50 62 19 8 20 12 13 8 1 0.436 1.000 1.000 358 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(7), CD4(3), CREBBP(12), CSK(2), GNAS(9), GNB1(4), GNGT1(1), HLA-DRB1(4), LCK(5), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PTPRC(9), ZAP70(3) 6905669 68 49 65 36 12 15 10 23 7 1 0.997 1.000 1.000 359 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(7), CD4(3), CREBBP(12), CSK(2), GNAS(9), GNB1(4), GNGT1(1), HLA-DRB1(4), LCK(5), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PTPRC(9), ZAP70(3) 6905669 68 49 65 36 12 15 10 23 7 1 0.997 1.000 1.000 360 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(2), BLVRA(2), CP(6), CPOX(3), EPRS(7), FECH(2), GUSB(6), HCCS(2), HMBS(3), HMOX1(1), HMOX2(2), PPOX(3), UGT1A1(1), UGT1A10(3), UGT1A3(2), UGT1A4(1), UGT1A5(13), UGT1A8(1), UGT1A9(1), UGT2B15(5), UGT2B4(5), UROS(3) 8156960 74 49 74 47 9 14 5 25 20 1 1.000 1.000 1.000 361 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 11 ADAM17(9), APC(12), AXIN1(14), BTRC(6), DLL1(2), DVL1(1), FZD1(1), GSK3B(6), NOTCH1(6), PSEN1(2), WNT1(3) 5954893 62 49 62 33 10 16 4 14 17 1 0.988 1.000 1.000 362 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 16 CHUK(9), CREBBP(12), EP300(7), FADD(2), HDAC3(2), IKBKB(6), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(6), TNF(2), TNFRSF1A(2), TNFRSF1B(3), TRAF6(1) 6872004 65 49 65 35 14 16 6 21 8 0 0.991 1.000 1.000 363 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(5), CARS(4), DARS(1), EPRS(7), FARS2(2), GARS(2), HARS(1), IARS(9), KARS(1), LARS(5), LARS2(2), MARS(7), MARS2(1), QARS(3), RARS(3), SARS(2), TARS(4), WARS(6), WARS2(1) 9536740 66 48 66 28 18 22 4 13 8 1 0.726 1.000 1.000 364 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(3), ACO2(4), CS(1), DLD(2), DLST(2), FH(4), IDH1(7), IDH2(5), IDH3B(1), IDH3G(2), MDH1(1), MDH2(2), PC(10), PCK1(6), SDHA(5), SDHB(3), SUCLA2(3), SUCLG1(2), SUCLG2(2) 6188664 65 48 63 28 8 11 17 21 8 0 0.871 1.000 1.000 365 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(2), CREB1(1), MAPK1(3), MAPK3(1), MAPK7(6), MEF2A(4), MEF2C(3), MEF2D(1), NTRK1(5), PIK3CA(10), PIK3R1(5), PLCG1(10), RPS6KA1(4), SHC1(5) 5963318 60 48 59 20 14 12 10 16 8 0 0.623 1.000 1.000 366 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(5), AKT1(2), CALM1(1), GNAS(9), GNB1(4), GNGT1(1), NFKB1(7), NOS3(8), NPPA(1), NR3C1(4), PIK3CA(10), PIK3R1(5), RELA(4), SYT1(1) 5469860 62 48 58 20 12 13 8 24 5 0 0.655 1.000 1.000 367 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASNS(6), ASRGL1(2), CA1(1), CA12(4), CA13(1), CA2(2), CA3(2), CA4(2), CA5A(4), CA5B(2), CA6(4), CA8(3), CA9(3), CPS1(10), CTH(3), GLS(4), GLS2(3), GLUD1(3), GLUD2(3), GLUL(3), HAL(2) 6289484 68 48 67 27 15 16 7 19 11 0 0.766 1.000 1.000 368 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(2), FOS(2), IL2(1), IL2RA(2), IL2RB(3), IL2RG(1), JAK1(8), JAK3(5), JUN(1), LCK(5), MAP2K1(5), MAPK3(1), RAF1(2), SHC1(5), SOS1(10), STAT5A(2), STAT5B(3), SYK(4) 7213419 62 48 62 21 13 14 12 14 8 1 0.623 1.000 1.000 369 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(2), ADCY1(7), CCNB1(4), CDC25C(1), GNAI1(4), GNAS(9), GNB1(4), GNGT1(1), MAPK1(3), MAPK3(1), MYT1(6), PIN1(1), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), RPS6KA1(4), SRC(2) 6200802 58 48 56 24 15 12 5 19 6 1 0.897 1.000 1.000 370 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCR1(3), CCR2(4), CCR3(3), CCR5(2), CCR7(4), CD4(3), CSF2(2), CXCR3(1), CXCR4(2), IFNG(3), IFNGR1(5), IFNGR2(2), IL12A(6), IL12B(2), IL12RB1(5), IL12RB2(10), IL18R1(3), IL2(1), IL4(1), IL4R(4), TGFB1(1), TGFB2(4), TGFB3(3) 6061964 75 48 75 28 13 23 5 25 9 0 0.800 1.000 1.000 371 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(12), ASAH1(4), CAMP(1), CASP3(2), CERK(2), CREB1(1), CREB3(2), CREB5(5), EPHB2(7), FOS(2), ITPKA(1), ITPKB(2), JUN(1), MAP2K4(4), MAP2K7(2), MAPK1(3), MAPK10(4), MAPK8IP3(2), MAPK9(4) 8513509 61 48 61 38 15 13 6 17 9 1 0.998 1.000 1.000 372 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), CHUK(9), IFNG(3), IKBKB(6), IL2(1), IL4(1), JUN(1), MAP3K1(6), MAP3K5(6), MAP4K5(11), MAPK14(4), NFKB1(7), NFKBIA(2), RELA(4) 5940204 62 47 61 28 13 13 8 17 11 0 0.913 1.000 1.000 373 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(1), CSF1R(3), DDX20(8), E2F1(2), E2F4(2), ETS1(1), ETS2(2), ETV3(2), FOS(2), HDAC2(5), HDAC5(3), JUN(1), NCOR2(11), RBL1(6), RBL2(8), SIN3A(5), SIN3B(6) 8080093 68 47 68 29 19 14 11 15 9 0 0.907 1.000 1.000 374 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 15 AKT1(2), AKT2(7), AKT3(4), BPNT1(2), ILK(1), MAPK1(3), MAPK3(1), PDK1(1), PIK3CA(10), PIK3CD(5), PTK2B(8), RBL2(8), SHC1(5), SOS1(10) 5800913 67 47 66 21 14 20 9 13 10 1 0.436 1.000 1.000 375 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(5), DYRK1B(2), GLI2(11), GLI3(13), GSK3B(6), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), SHH(2), SUFU(4) 4897111 52 47 52 16 9 10 3 21 8 1 0.654 1.000 1.000 376 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(2), ACAA2(2), ADH1A(2), ADH1B(6), ADH6(2), ADH7(3), ADHFE1(1), AKR1C4(3), AKR1D1(3), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(2), BAAT(2), CEL(2), CYP27A1(4), CYP7A1(3), HADHB(2), SOAT2(2) 6951336 55 46 54 39 10 16 6 15 8 0 0.999 1.000 1.000 377 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 23 ABL1(1), ATM(15), ATR(14), CCNA1(2), CCND1(1), CCNE1(2), CDC25A(2), CDK6(2), CDKN1A(6), CDKN1B(2), CDKN2A(3), E2F1(2), GSK3B(6), SKP2(3), TFDP1(3), TGFB1(1), TGFB2(4), TGFB3(3) 8182289 72 46 72 35 13 13 6 27 12 1 0.980 1.000 1.000 378 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 18 AKT1(2), EIF2B5(5), EIF2S1(1), EIF2S2(1), EIF2S3(2), EIF4E(2), EIF4EBP1(1), GSK3B(6), IGF1(1), IGF1R(12), INPPL1(3), PDK2(2), PDPK1(2), PIK3CA(10), PIK3R1(5), PPP2CA(4), RPS6(1), RPS6KB1(5) 5881881 65 46 64 22 15 17 7 18 8 0 0.480 1.000 1.000 379 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 28 ANXA2(1), ANXA3(5), ANXA4(3), ANXA6(3), ANXA8(1), CYP11A1(2), EDN1(2), EDNRA(3), EDNRB(2), HPGD(3), HSD11B1(2), PLA2G4A(6), PRL(2), PTGDR(1), PTGER2(5), PTGER4(1), PTGFR(3), PTGIR(2), PTGIS(2), PTGS1(3), PTGS2(2), S100A6(1), TBXAS1(2) 6559210 57 46 57 36 8 14 7 23 5 0 1.000 1.000 1.000 380 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(2), AKT2(7), AKT3(4), CDKN1A(6), MAP2K1(5), MAP2K2(3), NGFR(1), NTRK1(5), PIK3CA(10), PIK3CD(5), SHC1(5), SOS1(10) 4995277 63 46 62 19 13 18 9 17 5 1 0.383 1.000 1.000 381 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 16 DNAJA3(1), IFNG(3), IFNGR1(5), IFNGR2(2), IKBKB(6), JAK2(9), LIN7A(1), NFKB1(7), NFKBIA(2), RELA(4), TNF(2), TNFRSF1A(2), TNFRSF1B(3), USH1C(5), WT1(6) 4980877 58 46 58 20 13 13 7 19 6 0 0.644 1.000 1.000 382 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(1), ATM(15), BRCA1(11), CDKN1A(6), CHEK1(7), CHEK2(6), GADD45A(1), JUN(1), MDM2(2), MRE11A(3), NFKB1(7), NFKBIA(2), RAD50(4), RAD51(5), RBBP8(5), RELA(4), TP73(1) 8579592 81 45 81 28 13 10 9 34 14 1 0.817 1.000 1.000 383 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(10), ARHGDIB(1), BIRC2(6), BIRC3(6), CASP1(4), CASP10(4), CASP2(1), CASP3(2), CASP4(4), CASP6(2), CASP7(4), CASP8(3), CASP9(1), DFFA(2), DFFB(3), GZMB(1), LMNA(3), LMNB1(5), LMNB2(4), PRF1(4) 5808238 70 45 70 27 15 15 2 24 14 0 0.828 1.000 1.000 384 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(4), FOS(2), JUN(1), MAP2K1(5), MAPK1(3), MAPK3(1), MYC(2), NFKB1(7), NFKBIA(2), PLCB1(11), PRKCA(2), RAF1(2), RELA(4), TNF(2) 4595009 48 45 48 15 11 11 7 13 6 0 0.441 1.000 1.000 385 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(3), F2(2), F2R(2), F3(2), F5(18), FGA(9), FGB(2), FGG(4), PROC(5), PROS1(4), SERPINC1(4), TFPI(4) 4989001 59 45 57 30 8 19 11 14 7 0 0.921 1.000 1.000 386 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(5), GABBR1(6), GPRC5A(4), GPRC5B(1), GPRC5C(1), GPRC5D(2), GRM1(8), GRM2(3), GRM3(6), GRM4(4), GRM5(5), GRM7(8), GRM8(9) 6211711 62 45 61 30 10 15 9 24 4 0 0.957 1.000 1.000 387 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(1), HLA-A(11), IL18(2), ITGB1(3), KLRC1(1), KLRC2(1), KLRC4(2), KLRD1(1), MAP2K1(5), MAPK3(1), PAK1(4), PIK3CA(10), PIK3R1(5), PTK2B(8), PTPN6(2), RAC1(1), SYK(4), VAV1(6) 5702449 68 45 65 20 13 13 8 19 15 0 0.553 1.000 1.000 388 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 18 CHUK(9), DUSP1(1), IKBKAP(16), IKBKB(6), LTA(2), MAP3K1(6), MAP3K14(2), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(6), TANK(2), TNFAIP3(4), TNFRSF1B(3), TRAF1(3), TRAF3(1) 6974069 74 45 73 25 15 12 13 24 10 0 0.580 1.000 1.000 389 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(7), AKT1(2), BAX(1), BCL2(1), CSF2RB(3), IGF1(1), IGF1R(12), IL3(2), KIT(10), KITLG(2), PIK3CA(10), PIK3R1(5), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), YWHAH(1) 6558597 66 44 65 21 11 9 11 22 12 1 0.556 1.000 1.000 390 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(8), CSF1R(3), EGF(10), EGFR(7), MET(2), PDGFRA(10), PRKCA(2), SH3GLB1(2), SH3GLB2(1), SH3KBP1(4), SRC(2) 5798394 51 44 51 17 13 13 6 10 9 0 0.428 1.000 1.000 391 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(1), BCL2(1), CASP8(3), FADD(2), MAP2K1(5), MAP2K4(4), MAP3K1(6), MAPK1(3), MAPK3(1), NFKB1(7), NSMAF(3), RAF1(2), RELA(4), RIPK1(6), SMPD1(3), TNFRSF1A(2) 6074650 53 44 52 23 15 12 6 11 9 0 0.856 1.000 1.000 392 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(10), EGFR(7), MAP2K1(5), MAP3K1(6), MAPK14(4), NCOR2(11), RARA(2), RXRA(6), THRA(1), THRB(1) 5245020 53 44 53 25 10 18 6 10 9 0 0.947 1.000 1.000 393 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(5), BAIAP2(3), CASP1(4), CASP3(2), CASP7(4), CASP8(3), INSR(11), ITCH(2), MAGI1(6), MAGI2(8), RERE(4), WWP1(6), WWP2(3) 7046080 61 44 59 40 19 7 4 22 8 1 0.999 1.000 1.000 394 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), ASNS(6), CA1(1), CA12(4), CA2(2), CA3(2), CA4(2), CA5A(4), CA5B(2), CA6(4), CA8(3), CA9(3), CPS1(10), CTH(3), GLS(4), GLS2(3), GLUD1(3), GLUL(3), HAL(2) 5631100 62 44 61 26 15 15 4 17 11 0 0.853 1.000 1.000 395 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 21 AKT1(2), AP2A1(5), AP2M1(1), ARF1(2), BTK(1), EEA1(4), GRASP(1), GSK3A(2), GSK3B(6), LYN(3), PDPK1(2), PFKL(3), PFKM(2), PFKP(6), PLCG1(10), PRKCZ(3), RAC1(1), RPS6KB1(5), VAV2(2) 7385525 61 44 61 34 15 21 2 15 8 0 0.997 1.000 1.000 396 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 21 AKT1(2), CCND1(1), CCNE1(2), CDK6(2), CDKN1A(6), CDKN1B(2), E2F1(2), MAPK1(3), MAPK3(1), NFKB1(7), NFKBIA(2), PAK1(4), PIK3CA(10), PIK3R1(5), RAC1(1), RAF1(2), RELA(4), TFDP1(3) 5558050 59 44 58 19 12 10 8 21 8 0 0.565 1.000 1.000 397 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(1), ALDH18A1(1), ARG1(3), ARG2(2), ASL(2), CKB(1), CKM(2), CKMT1A(1), CKMT1B(1), CKMT2(5), CPS1(10), GAMT(1), GATM(6), GLUD1(3), NAGS(5), OAT(3), ODC1(3), OTC(3), PYCR1(2), SMS(1) 5608328 56 44 56 18 14 17 5 13 7 0 0.470 1.000 1.000 398 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 9 AKAP9(22), MAP2(17), PPP1CA(3), PPP2CA(4), PRKACB(3), PRKACG(1), PRKAR2A(3), PRKAR2B(1) 5030059 54 43 53 20 12 16 3 13 9 1 0.615 1.000 1.000 399 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 15 C1QA(2), C1R(1), C1S(4), C2(9), C3(12), C4A(2), C5(9), C6(2), C7(3), C8A(3), C8B(7), C9(3), MASP1(4) 10361122 61 43 61 42 14 16 7 17 7 0 1.000 1.000 1.000 400 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(10), BST1(2), CD38(2), ENPP1(4), ENPP3(8), NADK(4), NADSYN1(4), NMNAT1(2), NMNAT2(1), NMNAT3(2), NNT(4), NT5C(1), NT5C1A(2), NT5C1B(2), NT5C2(6), NUDT12(2) 6458955 56 43 56 24 9 18 7 17 4 1 0.784 1.000 1.000 401 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(8), ACE2(2), AGT(2), AGTR1(3), ANPEP(5), CPA3(4), CTSA(3), CTSG(1), ENPEP(5), LNPEP(10), MME(8), NLN(7), REN(1), THOP1(1) 6320735 60 43 60 21 13 18 3 12 13 1 0.748 1.000 1.000 402 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(7), IL22(2), IL22RA1(1), JAK1(8), JAK2(9), JAK3(5), STAT1(7), STAT3(5), STAT5A(2), STAT5B(3), TYK2(7) 5725032 56 43 56 19 13 17 6 13 7 0 0.697 1.000 1.000 403 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(2), CASP9(1), CDC42(2), CHUK(9), MAP2K1(5), MAPK3(1), NFKB1(7), PIK3CA(10), PIK3R1(5), RAC1(1), RAF1(2), RALA(2), RALBP1(1), RALGDS(4), RELA(4) 5881453 56 43 55 30 10 10 10 17 9 0 0.982 1.000 1.000 404 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(12), CDH1(4), CREBBP(12), EP300(7), MAP2K1(5), MAP3K7(3), MAPK3(1), SKIL(2), TGFB1(1), TGFB2(4), TGFB3(3), TGFBR1(5), TGFBR2(1) 7704147 60 43 60 44 8 24 8 12 7 1 0.999 1.000 1.000 405 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(2), CREB1(1), CREBBP(12), EP300(7), NCOA3(13), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), RARA(2), RXRA(6) 6193127 52 42 52 30 7 18 3 14 9 1 0.995 1.000 1.000 406 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(3), FBP1(2), FBP2(1), G6PD(3), GPI(2), H6PD(3), PFKL(3), PFKM(2), PFKP(6), PGD(2), PGM1(3), PGM3(6), PRPS1(1), PRPS1L1(2), PRPS2(3), RBKS(1), RPE(1), TALDO1(3), TKT(1), TKTL1(3), TKTL2(7) 7300686 58 42 58 39 14 15 2 20 7 0 1.000 1.000 1.000 407 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 37 ANPEP(5), G6PD(3), GCLM(1), GPX1(2), GPX2(2), GPX5(2), GPX6(2), GPX7(1), GSR(3), GSS(4), GSTA2(2), GSTA4(2), GSTA5(1), GSTK1(1), GSTM2(1), GSTM3(1), GSTM5(2), GSTO2(2), GSTP1(4), GSTT1(1), GSTT2(3), GSTZ1(2), IDH1(7), IDH2(5), MGST1(1), MGST3(1), OPLAH(6) 7048189 67 42 64 25 17 14 11 17 8 0 0.678 1.000 1.000 408 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(7), COL4A2(10), COL4A3(4), COL4A4(11), COL4A5(9), COL4A6(11), P4HB(1), SLC23A1(2), SLC23A2(2), SLC2A3(3) 7767579 60 42 58 43 12 14 11 19 4 0 0.957 1.000 1.000 409 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(2), CASP9(1), CHUK(9), GH1(2), GHR(8), NFKB1(7), NFKBIA(2), PDPK1(2), PIK3CA(10), PIK3R1(5), PPP2CA(4), RELA(4), YWHAH(1) 4413033 57 41 56 20 13 8 9 19 8 0 0.591 1.000 1.000 410 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 13 CHUK(9), DUSP1(1), IKBKAP(16), IKBKB(6), MAP3K1(6), MAP3K14(2), NFKB1(7), NFKBIA(2), RELA(4), TNFAIP3(4), TRAF3(1), TRAF6(1) 5729495 59 41 58 25 12 10 11 17 9 0 0.846 1.000 1.000 411 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 15 AKT1(2), CREB1(1), MAP2K1(5), MAP2K2(3), MAP2K6(1), MAP3K1(6), MAPK1(3), MAPK14(4), MAPK3(1), NFKB1(7), PIK3CA(10), PIK3R1(5), RELA(4), SP1(2) 5398936 54 41 53 23 13 13 8 12 8 0 0.858 1.000 1.000 412 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 24 AKR1B1(2), DCXR(1), GUSB(6), RPE(1), UGDH(4), UGP2(2), UGT1A1(1), UGT1A10(3), UGT1A3(2), UGT1A4(1), UGT1A5(13), UGT1A8(1), UGT1A9(1), UGT2A1(5), UGT2A3(3), UGT2B10(2), UGT2B11(3), UGT2B15(5), UGT2B17(1), UGT2B4(5), UGT2B7(5), XYLB(1) 7444246 68 41 67 44 8 19 6 21 14 0 1.000 1.000 1.000 413 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(10), ACACB(14), FASN(18), MCAT(5), OLAH(4), OXSM(4) 4915137 55 41 55 28 18 11 10 9 7 0 0.929 1.000 1.000 414 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AMD1(3), BHMT(2), CBS(5), CTH(3), DNMT1(4), DNMT3A(4), DNMT3B(5), MARS(7), MARS2(1), MAT1A(4), MAT2B(1), MTAP(2), MTFMT(2), MTR(5), SRM(3), TAT(1) 6278341 52 41 52 19 9 11 4 17 11 0 0.745 1.000 1.000 415 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(2), EXT2(3), EXTL1(5), EXTL2(1), EXTL3(4), GLCE(3), HS2ST1(3), HS3ST1(1), HS3ST2(1), HS3ST3A1(3), HS3ST5(3), HS6ST1(1), HS6ST2(1), HS6ST3(4), NDST1(3), NDST2(3), NDST3(5), NDST4(7) 6280606 53 41 53 28 11 21 1 14 6 0 0.988 1.000 1.000 416 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(2), AGT(2), AGTR1(3), COL4A1(7), COL4A2(10), COL4A3(4), COL4A4(11), COL4A5(9), COL4A6(11), REN(1) 7733032 60 40 58 35 14 14 10 16 6 0 0.795 1.000 1.000 417 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(5), ACP2(1), ACP5(2), ACP6(2), ACPP(5), ACPT(1), ALPI(1), ALPL(3), ALPP(6), ALPPL2(3), CMBL(2), CYP3A4(1), CYP3A43(3), CYP3A5(4), CYP3A7(6), DHRS1(1), DHRS3(1), DHRS7(2), DHRSX(5), PON1(2), PON3(1) 5529279 57 40 54 25 15 6 6 20 10 0 0.952 1.000 1.000 418 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), ALG5(1), B4GALT2(2), B4GALT3(2), B4GALT5(2), DDOST(1), DPAGT1(3), DPM1(1), FUT8(2), MAN1A1(3), MAN1B1(1), MGAT1(3), MGAT2(2), MGAT3(8), MGAT4A(2), MGAT5(5), RPN1(2), RPN2(2), ST6GAL1(2) 6003783 45 40 44 21 13 10 5 9 8 0 0.848 1.000 1.000 419 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(5), AP2A1(5), AP2M1(1), BIN1(4), CALM1(1), DNM1(3), EPN1(5), EPS15(2), NME1(1), PICALM(2), PPP3CA(6), PPP3CB(5), PPP3CC(1), SYNJ1(10), SYNJ2(2), SYT1(1) 6811679 54 40 53 26 9 11 8 19 7 0 0.921 1.000 1.000 420 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(10), BIRC2(6), BIRC3(6), CASP10(4), CASP3(2), CASP7(4), CASP8(3), CASP9(1), DFFA(2), DFFB(3), GZMB(1), PRF1(4), SCAP(4), SREBF1(4), SREBF2(7) 5596039 61 40 61 19 14 12 2 19 14 0 0.540 1.000 1.000 421 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(2), ACTR2(2), ACTR3(3), ARPC1A(2), ARPC1B(2), ARPC2(5), ARPC4(2), NCK1(1), NCKAP1(6), NTRK1(5), PIR(1), PSMA7(4), RAC1(1), WASF1(2), WASF2(2), WASF3(4), WASL(2) 4606524 46 39 45 25 11 16 6 7 6 0 0.937 1.000 1.000 422 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 12 ACTN1(5), ACTN2(8), ACTN3(1), BCAR1(3), CSK(2), CTNNA1(1), CTNNA2(10), PECAM1(1), PTK2(9), PXN(5), SRC(2), VCL(4) 5332608 51 39 51 17 8 14 4 17 8 0 0.751 1.000 1.000 423 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 16 C1QA(2), C1R(1), C1S(4), C2(9), C3(12), C4A(2), C5(9), C6(2), C7(3), C8A(3), C9(3), MASP1(4), MASP2(4), MBL2(1) 10564069 59 39 59 43 12 14 9 16 8 0 1.000 1.000 1.000 424 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(3), GABARAP(1), GABRA1(5), GABRA2(4), GABRA3(3), GABRA4(8), GABRA5(4), GABRA6(6), GPHN(9), SRC(2), UBQLN1(3) 3831143 48 39 48 22 4 11 2 21 10 0 0.968 1.000 1.000 425 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(4), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(5), ALDH3B2(4), ALDH9A1(2), AOC2(3), AOC3(3), ASPA(1), CNDP1(2), DDC(4), HAL(2), HARS(1), HDC(5), MAOA(4), MAOB(3), PRPS1(1), PRPS2(3) 7327611 61 39 59 31 13 7 7 24 9 1 0.979 1.000 1.000 426 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(1), B3GAT2(2), B3GAT3(1), CHPF(9), CHST11(1), CHST12(3), CHST13(2), CHST14(2), CHST3(5), CHST7(1), CHSY1(2), DSE(9), UST(3), XYLT1(7), XYLT2(3) 4120337 51 39 51 22 10 8 4 22 7 0 0.953 1.000 1.000 427 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(1), ACAT2(6), ACOT11(3), ACYP1(1), ACYP2(1), DHRS1(1), DHRS3(1), DHRS7(2), DHRSX(5), ECHS1(2), EHHADH(14), ESCO1(4), ESCO2(5), FN3K(1), GCDH(2), HADHA(3), NAT6(2), PNPLA3(3), SH3GLB1(2) 7699366 59 39 57 26 15 9 8 20 7 0 0.766 1.000 1.000 428 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(5), BCAT2(2), COASY(3), DPYD(17), ENPP1(4), ENPP3(8), ILVBL(1), PANK1(1), PANK2(2), PANK3(2), PANK4(2), PPCDC(2), PPCS(2), UPB1(1), VNN1(5) 5180014 57 39 54 21 13 15 10 16 3 0 0.540 1.000 1.000 429 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(10), POLR1B(3), POLR1C(1), POLR1D(1), POLR2A(10), POLR2B(8), POLR2C(1), POLR2E(2), POLR2G(2), POLR2H(1), POLR2I(2), POLR3A(9), POLR3B(4), POLR3K(1), ZNRD1(1) 6969907 56 39 56 35 19 12 4 13 8 0 0.998 1.000 1.000 430 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CAMK1G(3), CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(1), ESRRA(4), HDAC5(3), MEF2A(4), MEF2C(3), MEF2D(1), PPARA(4), PPP3CA(6), PPP3CB(5), PPP3CC(1), SLC2A4(1), SYT1(1), YWHAH(1) 6374683 52 39 52 23 12 11 3 18 8 0 0.928 1.000 1.000 431 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(4), HLA-DRB1(4), IFNG(3), IFNGR1(5), IFNGR2(2), IL12A(6), IL12B(2), IL12RB1(5), IL12RB2(10), IL18(2), IL18R1(3), IL2(1), IL2RA(2), IL4(1), IL4R(4) 3796169 54 39 53 25 10 13 7 14 10 0 0.920 1.000 1.000 432 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(5), CD2(2), CD33(3), CD5(6), CSF2(2), IFNB1(1), IFNG(3), IL12A(6), IL12B(2), IL3(2), IL4(1), ITGAX(7), TLR2(2), TLR4(3), TLR7(7), TLR9(3) 5568150 55 38 54 22 12 8 11 17 7 0 0.691 1.000 1.000 433 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 FUCA1(2), FUCA2(1), GLB1(6), HEXA(2), HEXB(1), LCT(7), MAN2B1(2), MAN2B2(7), MAN2C1(10), MANBA(2), NEU1(5), NEU2(3), NEU3(2), NEU4(3) 6240739 53 38 53 21 15 13 7 15 3 0 0.713 1.000 1.000 434 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(2), ACAD9(4), ADH1A(2), ADH1B(6), ADH5(1), ADH6(2), ADH7(3), ADHFE1(1), DHRS1(1), DHRS3(1), DHRS7(2), DHRSX(5), ESCO1(4), ESCO2(5), NAT6(2), PNPLA3(3), SH3GLB1(2) 7401227 46 38 44 30 12 12 3 8 11 0 0.996 1.000 1.000 435 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(3), ICAM1(2), ITGA4(7), ITGAL(7), ITGAM(7), ITGB1(3), ITGB2(9), PECAM1(1), SELE(2), SELL(2), SELP(8) 4894686 51 38 48 25 13 11 7 12 8 0 0.937 1.000 1.000 436 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(6), ARHGEF1(3), GNA12(1), GNA13(2), GNB1(4), GNGT1(1), MYLK(4), PLCB1(11), PPP1R12B(5), PRKCA(2), ROCK1(7) 6210960 46 38 46 18 7 14 3 12 10 0 0.821 1.000 1.000 437 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(2), CYB5R3(3), GCK(3), GFPT1(2), GNE(6), GNPDA2(3), HEXA(2), HEXB(1), HK1(4), HK2(8), HK3(6), PGM3(6), UAP1(3) 5158553 49 37 49 28 13 10 7 14 5 0 0.969 1.000 1.000 438 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 9 CD80(1), CR2(9), FCGR2B(3), HLA-DRB1(4), ICAM1(2), ITGAL(7), ITGB2(9), PTPRC(9) 3578561 44 37 41 25 10 12 9 10 3 0 0.967 1.000 1.000 439 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 CALM1(1), CDKN1A(6), NFATC1(3), NFATC2(4), NFATC3(4), NFATC4(5), PLCG1(10), PPP3CA(6), PPP3CB(5), PPP3CC(1), PRKCA(2), SP1(2), SP3(3), SYT1(1) 6021641 53 37 53 22 11 15 3 16 8 0 0.849 1.000 1.000 440 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(7), GNAS(9), GNB1(4), GNGT1(1), PPP2CA(4), PRKAA1(4), PRKAA2(4), PRKAB1(1), PRKAB2(1), PRKACB(3), PRKACG(1), PRKAG2(3), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1) 4639162 47 37 45 17 12 10 4 15 5 1 0.784 1.000 1.000 441 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(5), BCAT2(2), IARS(9), IARS2(2), ILVBL(1), LARS(5), LARS2(2), PDHA1(1), PDHA2(4), PDHB(2), VARS(2), VARS2(12) 5578256 47 37 47 28 16 9 6 12 3 1 0.973 1.000 1.000 442 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(5), AMT(1), ATIC(1), FTCD(5), GART(10), MTFMT(2), MTHFD1(8), MTHFD1L(5), MTHFD2(1), MTHFR(4), MTR(5), SHMT1(4), SHMT2(2) 5747412 53 37 53 19 18 11 3 14 7 0 0.453 1.000 1.000 443 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(3), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH7A1(2), ALDH9A1(2), CYP2C9(4), DHRS1(1), DHRS3(1), DHRS7(2), DHRSX(5), ECHS1(2), EHHADH(14), ESCO1(4), ESCO2(5), HADHA(3), NAT6(2), PNPLA3(3), SH3GLB1(2) 9199499 65 37 63 26 18 12 8 22 5 0 0.600 1.000 1.000 444 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(1), MRPL13(4), MRPS7(1), RPL10A(2), RPL10L(1), RPL11(1), RPL13(2), RPL18(3), RPL18A(1), RPL23A(1), RPL27(1), RPL29(1), RPL3(2), RPL37(1), RPL38(1), RPL3L(1), RPL41(1), RPL6(2), RPL9(1), RPS10(1), RPS13(2), RPS15A(1), RPS18(1), RPS2(1), RPS23(1), RPS24(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(2), RPS6(1), RPS9(2) 6435858 45 37 45 19 11 11 4 13 6 0 0.893 1.000 1.000 445 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(3), CSF1(1), CSF2(2), HLA-DRB1(4), IFNB1(1), IFNG(3), IL12A(6), IL12B(2), IL1A(3), IL2(1), IL3(2), IL4(1), IL6(3), IL7(2), LTA(2), PDGFA(2), TGFB1(1), TGFB2(4), TGFB3(3), TNF(2) 4121889 48 37 47 24 4 10 12 18 4 0 0.951 1.000 1.000 446 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(12), EP300(7), LPL(4), NCOA1(6), NCOA2(10), PPARG(1), RXRA(6) 5486050 46 37 45 23 9 16 6 12 3 0 0.909 1.000 1.000 447 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(7), ADRB2(5), CFTR(12), GNAS(9), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), SLC9A3R1(1) 3921247 43 36 41 15 7 8 6 15 6 1 0.814 1.000 1.000 448 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(4), POLD1(5), POLE(9), POLG(7), POLL(1), POLQ(18) 4996065 44 36 44 15 12 12 4 10 6 0 0.593 1.000 1.000 449 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(2), CHPT1(3), HEMK1(5), LCMT1(2), LCMT2(4), METTL2B(6), METTL6(1), PCYT1A(4), PCYT1B(2), PRMT3(2), PRMT5(4), PRMT6(4), PRMT7(1), PRMT8(3), WBSCR22(1) 4166822 44 36 44 20 14 7 7 11 3 2 0.902 1.000 1.000 450 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(1), GALNS(3), GLB1(6), GNS(2), GUSB(6), HEXA(2), HEXB(1), HGSNAT(3), HPSE(1), HPSE2(2), HYAL1(2), HYAL2(2), IDUA(4), LCT(7), NAGLU(4), SPAM1(5) 6283076 51 36 51 37 12 4 10 18 7 0 0.999 1.000 1.000 451 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1L(2), GOSR1(3), GOSR2(4), SNAP25(2), SNAP29(1), STX10(1), STX12(4), STX16(1), STX18(2), STX19(4), STX2(4), STX3(3), STX4(1), STX5(2), STX6(1), TSNARE1(9), USE1(2), VAMP1(1), VAMP3(1), VAMP8(1), VTI1A(2), YKT6(2) 5101727 53 36 53 18 14 12 7 15 5 0 0.617 1.000 1.000 452 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(7), ABCC2(6), ABCG2(5), BCHE(4), CES1(3), CES2(1), CYP3A4(1), CYP3A5(4), UGT1A1(1), UGT1A10(3), UGT1A3(2), UGT1A4(1), UGT1A5(13), UGT1A8(1), UGT1A9(1) 6899267 53 36 53 32 8 17 5 14 9 0 0.995 1.000 1.000 453 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(11), ABCB11(8), ABCB4(6), ABCC1(7), ABCC3(10), GSTP1(4) 4362727 46 36 45 18 3 14 7 17 5 0 0.736 1.000 1.000 454 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(11), AKT1(2), ATM(15), BAX(1), CDKN1A(6), CPB2(3), CSNK1A1(1), FHL2(2), GADD45A(1), HIC1(1), HIF1A(3), IGFBP3(1), MDM2(2), NQO1(2) 6191863 51 36 50 22 6 5 5 26 9 0 0.951 1.000 1.000 455 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(1), CDK5R1(1), DRD2(2), GRM1(8), PLCB1(11), PPP1CA(3), PPP1R1B(2), PPP2CA(4), PPP3CA(6), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1) 4800662 47 35 47 16 15 8 4 14 5 1 0.626 1.000 1.000 456 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 13 C1QA(2), C1R(1), C1S(4), C2(9), C3(12), C4A(2), C5(9), C6(2), C7(3), C8A(3), C9(3) 9379472 50 35 50 40 9 11 7 16 7 0 1.000 1.000 1.000 457 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(2), EPHA4(3), EPHB1(6), FYN(2), ITGA1(7), ITGB1(3), L1CAM(5), LYN(3), SELP(8) 4720951 39 35 38 25 7 8 6 15 3 0 0.992 1.000 1.000 458 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(3), F13A1(4), F2(2), F2R(2), FGA(9), FGB(2), FGG(4), PLAT(2), PLAU(6), PLG(1), SERPINB2(2), SERPINE1(4) 4014065 41 35 39 17 8 9 8 7 9 0 0.801 1.000 1.000 459 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(1), CYP51A1(2), DHCR24(2), DHCR7(1), FDFT1(1), FDPS(3), GGCX(5), GGPS1(2), HMGCR(5), HSD17B7(2), IDI1(2), IDI2(1), LSS(3), MVD(2), MVK(1), NQO1(2), NSDHL(2), PMVK(3), SQLE(3), TM7SF2(1), VKORC1(1) 5851904 45 35 43 19 9 8 6 13 8 1 0.896 1.000 1.000 460 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(2), DHRS1(1), DHRS3(1), DHRS7(2), DHRSX(5), HEMK1(5), LCMT1(2), LCMT2(4), METTL2B(6), METTL6(1), PRMT3(2), PRMT5(4), PRMT6(4), PRMT7(1), PRMT8(3), WBSCR22(1) 4437675 44 35 42 16 19 6 6 10 1 2 0.624 1.000 1.000 461 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(2), IL2RG(1), IL4(1), IL4R(4), IRS1(4), JAK1(8), JAK3(5), RPS6KB1(5), SHC1(5), STAT6(6) 4410993 41 35 41 18 8 12 5 9 7 0 0.940 1.000 1.000 462 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 14 ABL1(1), CDKN2A(3), E2F1(2), MDM2(2), MYC(2), PIK3CA(10), PIK3R1(5), POLR1A(10), POLR1B(3), POLR1C(1), POLR1D(1), RAC1(1), TBX2(4) 5172304 45 34 43 20 8 9 5 16 7 0 0.935 1.000 1.000 463 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(2), ACHE(2), CHAT(5), COMT(1), DBH(2), DDC(4), GAD1(5), GAD2(2), HDC(5), MAOA(4), PAH(1), TH(3), TPH1(3) 4245899 39 34 39 22 12 6 3 13 5 0 0.989 1.000 1.000 464 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(4), KHK(1), LCT(7), MPI(2), PGM1(3), PYGL(8), PYGM(9), TREH(5) 4164452 39 34 37 14 11 7 7 8 6 0 0.572 1.000 1.000 465 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(5), G6PD(3), GCLM(1), GPX1(2), GPX2(2), GPX5(2), GSS(4), GSTA2(2), GSTA4(2), GSTM2(1), GSTM3(1), GSTM5(2), GSTO2(2), GSTP1(4), GSTT1(1), GSTT2(3), GSTZ1(2), IDH1(7), IDH2(5), MGST1(1), MGST3(1), PGD(2) 5788150 55 34 52 23 16 13 10 10 6 0 0.720 1.000 1.000 466 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(3), B4GALNT1(4), GLB1(6), HEXA(2), HEXB(1), LCT(7), SLC33A1(3), ST3GAL1(1), ST3GAL5(2), ST6GALNAC3(4), ST6GALNAC4(1), ST6GALNAC5(3), ST6GALNAC6(1), ST8SIA1(4), ST8SIA5(1) 4885381 43 34 43 19 7 11 7 13 5 0 0.799 1.000 1.000 467 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(5), ACP2(1), ACP5(2), ACP6(2), ACPP(5), ACPT(1), ENPP1(4), ENPP3(8), FLAD1(4), LHPP(1), MTMR1(2), MTMR2(3), MTMR6(5), PHPT1(1), RFK(1), TYR(6) 4550331 51 34 51 23 6 11 8 21 5 0 0.937 1.000 1.000 468 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(2), ACOX1(6), ACOX3(7), ELOVL2(4), ELOVL5(1), FADS1(1), FADS2(1), FASN(18), HADHA(3), PECR(4), SCD(2) 4581406 49 34 48 24 14 8 8 11 8 0 0.912 1.000 1.000 469 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), HMOX1(1), IL10RA(7), IL10RB(2), IL1A(3), IL6(3), JAK1(8), STAT1(7), STAT3(5), STAT5A(2), TNF(2) 3701416 42 34 42 16 9 9 4 16 4 0 0.883 1.000 1.000 470 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(5), AMT(1), ATIC(1), ATP6V0C(1), GART(10), MTHFD1(8), MTHFD1L(5), MTHFD2(1), MTHFR(4), MTR(5), SHMT1(4), SHMT2(2) 5364059 47 34 47 17 17 10 3 13 4 0 0.385 1.000 1.000 471 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(8), JAK2(9), JAK3(5), MAPK1(3), MAPK3(1), STAT3(5), TYK2(7) 3619958 38 34 38 11 8 13 5 7 5 0 0.457 1.000 1.000 472 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(3), ABP1(4), AOC2(3), AOC3(3), CES1(3), DDHD1(5), ESCO1(4), ESCO2(5), LIPA(5), NAT6(2), PLA1A(3), PNPLA3(3), PPME1(2), PRDX6(1), SH3GLB1(2) 7586012 48 33 48 18 8 11 7 18 4 0 0.534 1.000 1.000 473 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(3), CLOCK(4), CRY1(5), CSNK1E(3), NPAS2(7), NR1D1(3), PER1(4), PER2(7), PER3(4) 5118510 40 33 39 21 8 16 2 8 6 0 0.964 1.000 1.000 474 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 BHMT(2), CBS(5), CTH(3), DNMT1(4), DNMT3A(4), DNMT3B(5), MARS(7), MARS2(1), MAT1A(4), MAT2B(1), MTR(5) 5260142 41 33 41 18 6 10 1 16 8 0 0.939 1.000 1.000 475 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(6), ACADM(1), ACADS(3), ACADVL(3), ACSL1(3), ACSL3(3), ACSL4(2), CPT1A(6), CPT2(1), EHHADH(14), HADHA(3), PECR(4), SCP2(2), SLC25A20(1) 5013835 52 33 52 24 7 10 9 19 7 0 0.863 1.000 1.000 476 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 FUCA1(2), FUCA2(1), GLB1(6), HEXA(2), HEXB(1), LCT(7), MAN2C1(10), MANBA(2), NEU1(5), NEU2(3), NEU3(2), NEU4(3) 5080133 44 33 44 17 11 12 7 13 1 0 0.586 1.000 1.000 477 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(3), FBP1(2), FBP2(1), G6PD(3), GPI(2), H6PD(3), PFKM(2), PFKP(6), PGD(2), PGM1(3), PGM3(6), PRPS1(1), PRPS1L1(2), PRPS2(3), RBKS(1), RPE(1), TAL1(1), TALDO1(3), TKT(1) 6025550 46 33 46 34 13 11 0 15 7 0 1.000 1.000 1.000 478 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(7), ADRB2(5), GNAS(9), PLCE1(14), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1) 4449460 44 33 42 16 10 8 7 15 3 1 0.738 1.000 1.000 479 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 11 CREBBP(12), DAXX(1), PAX3(6), PML(5), RARA(2), SIRT1(5), SP100(3), TNF(2), TNFRSF1A(2), TNFRSF1B(3) 4833948 41 33 41 18 7 17 5 10 2 0 0.850 1.000 1.000 480 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(2), IL6(3), IL6R(1), JAK1(8), JAK2(9), JAK3(5), PTPRU(3), SRC(2), STAT3(5) 4635544 38 33 38 18 3 13 6 9 7 0 0.954 1.000 1.000 481 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(15), CDC25A(2), CDC25B(4), CDC25C(1), CHEK1(7), MYT1(6), WEE1(4), YWHAH(1) 4140624 40 32 40 17 8 8 2 17 5 0 0.867 1.000 1.000 482 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(3), HK1(4), HK2(8), HK3(6), IMPA1(3), IMPA2(3), PGM1(3), PGM3(6), TGDS(1) 3566411 37 32 37 19 8 7 5 13 4 0 0.948 1.000 1.000 483 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(3), FBP1(2), FBP2(1), GOT1(2), GOT2(2), GPT(5), GPT2(3), MDH1(1), MDH2(2), ME1(1), ME3(1), PGK1(2), PGK2(2), PKLR(1), RPE(1), TKT(1), TKTL1(3), TKTL2(7) 6058883 40 32 40 28 10 8 5 14 3 0 0.997 1.000 1.000 484 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(3), ICAM1(2), ITGA4(7), ITGAL(7), ITGB1(3), ITGB2(9), PECAM1(1), SELE(2), SELL(2) 3677873 36 32 34 17 9 10 2 8 7 0 0.913 1.000 1.000 485 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(8), CALM1(1), CAPN2(1), CAPNS1(1), EP300(7), HDAC2(5), MEF2D(1), NFATC1(3), NFATC2(4), PPP3CA(6), PPP3CB(5), PPP3CC(1), PRKCA(2), SYT1(1) 7198788 46 32 46 24 8 11 4 16 7 0 0.970 1.000 1.000 486 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(4), GALNT3(3), GALNT4(7), GALNT6(4), GALNT8(6), GALNT9(3), ST3GAL1(1), ST3GAL4(1), WBSCR17(7) 4386334 36 32 35 18 7 6 5 14 4 0 0.915 1.000 1.000 487 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(15), ATR(14), CDC25C(1), CHEK1(7), CHEK2(6), YWHAH(1) 4468136 44 32 44 19 9 6 3 18 7 1 0.880 1.000 1.000 488 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 10 ATM(15), CDC25A(2), CDC25B(4), CDC25C(1), CHEK1(7), MYT1(6), WEE1(4), YWHAH(1) 4510529 40 32 40 18 8 8 2 17 5 0 0.910 1.000 1.000 489 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(5), IFNB1(1), JAK1(8), PTPRU(3), STAT1(7), STAT2(6), TYK2(7) 3748636 37 32 37 18 10 8 4 10 5 0 0.965 1.000 1.000 490 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNA1(2), CCNB1(4), CCND1(1), CCND2(1), CCNE1(2), CCNH(3), CDC25A(2), CDK6(2), CDK7(1), CDKN1A(6), CDKN1B(2), CDKN2A(3), CDKN2C(1), E2F1(2), RBL1(6), TFDP1(3) 4204968 41 31 41 17 8 8 4 14 7 0 0.807 1.000 1.000 491 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD80(1), CD86(4), CTLA4(3), HLA-DRB1(4), IL2(1), ITK(2), LCK(5), PIK3CA(10), PIK3R1(5), PTPN11(2) 3839086 37 31 34 22 3 10 9 11 4 0 0.989 1.000 1.000 492 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 14 APAF1(10), ATM(15), BAX(1), BCL2(1), CCND1(1), CCNE1(2), CDKN1A(6), E2F1(2), GADD45A(1), MDM2(2) 4616186 41 31 41 19 7 5 2 22 5 0 0.943 1.000 1.000 493 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(3), ATP6V1D(2), ATP6V1F(2), ATP6V1G3(1), ATP6V1H(2), FDXR(3), SHMT1(4) 4819456 42 31 42 23 12 6 3 13 8 0 0.985 1.000 1.000 494 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(9), MAP3K14(2), MAPK14(4), NFKB1(7), RELA(4), TNFRSF13B(1), TNFRSF17(1), TNFSF13(2), TNFSF13B(2), TRAF3(1), TRAF5(2), TRAF6(1) 4325042 36 31 35 19 6 7 9 6 8 0 0.946 1.000 1.000 495 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(1), GZMB(1), HLA-A(11), ICAM1(2), ITGAL(7), ITGB2(9), PRF1(4) 2557223 35 30 33 11 6 8 2 12 7 0 0.674 1.000 1.000 496 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(10), ARHGAP5(6), ARHGDIB(1), CASP1(4), CASP10(4), CASP3(2), CASP8(3), CASP9(1), GZMB(1), JUN(1), PRF1(4) 3794258 37 30 37 20 6 7 1 17 6 0 0.972 1.000 1.000 497 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(9), EIF2AK4(7), EIF2B5(5), EIF2S1(1), EIF2S2(1), EIF2S3(2), EIF5(2), GSK3B(6), PPP1CA(3) 3444865 36 30 35 16 10 11 2 9 4 0 0.755 1.000 1.000 498 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(5), IFNAR2(1), IFNB1(1), JAK1(8), STAT1(7), STAT2(6), TYK2(7) 3265249 35 30 35 15 9 7 3 10 6 0 0.909 1.000 1.000 499 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(10), CPT1A(6), LEP(1), LEPR(7), PRKAA1(4), PRKAA2(4), PRKAB1(1), PRKAB2(1), PRKAG2(3) 4309519 37 30 37 21 12 8 3 9 5 0 0.956 1.000 1.000 500 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(2), IFNG(3), IFNGR1(5), JAK1(8), JAK2(9), PLA2G2A(1), PTPRU(3), STAT1(7) 3439468 38 30 38 16 5 12 3 10 8 0 0.922 1.000 1.000 501 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(3), ATP6V1D(2), ATP6V1F(2), ATP6V1G3(1), ATP6V1H(2), SHMT1(4) 4542657 39 29 39 23 11 5 3 12 8 0 0.992 1.000 1.000 502 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CCR5(2), CXCL12(2), CXCR4(2), FOS(2), JUN(1), MAPK14(4), PLCG1(10), PRKCA(2), PTK2B(8), SYT1(1) 4043419 35 29 35 15 9 9 3 4 10 0 0.936 1.000 1.000 503 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(4), EGF(10), EGFR(7), HGS(10), TF(3), TFRC(1) 3819960 35 29 35 22 2 9 1 11 12 0 0.998 1.000 1.000 504 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(9), ERBB4(9), NRG2(3), NRG3(7), PRKCA(2), PSEN1(2) 2705570 32 29 32 11 7 7 3 12 2 1 0.640 1.000 1.000 505 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(3), ATP6V1D(2), ATP6V1F(2), ATP6V1G3(1), ATP6V1H(2), SHMT1(4) 4542657 39 29 39 23 11 5 3 12 8 0 0.992 1.000 1.000 506 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(4), CARS2(2), CDO1(1), CTH(3), GOT1(2), GOT2(2), LDHA(1), LDHAL6A(2), LDHAL6B(7), LDHB(2), LDHC(2), SDS(4), SULT1C2(2), SULT1C4(2) 3755596 36 29 35 22 9 14 1 9 3 0 0.985 1.000 1.000 507 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 14 BPNT1(2), CHST11(1), CHST12(3), CHST13(2), PAPSS1(4), PAPSS2(5), SULT1A1(4), SULT1A2(4), SULT1E1(1), SULT2A1(3), SULT2B1(3), SUOX(4) 3449587 36 29 33 10 11 6 3 11 5 0 0.574 1.000 1.000 508 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(1), ADSS(3), HPRT1(1), IMPDH1(2), MTHFD2(1), POLB(4), POLD1(5), POLG(7), PRPS2(3), RRM1(5), SRM(3) 3861411 35 29 35 12 8 11 2 10 4 0 0.586 1.000 1.000 509 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), DCXR(1), GUSB(6), RPE(1), UCHL1(1), UCHL3(1), UGDH(4), UGT1A1(1), UGT1A10(3), UGT1A3(2), UGT1A4(1), UGT1A5(13), UGT1A8(1), UGT1A9(1), UGT2B15(5), UGT2B4(5) 5206071 48 29 48 33 7 15 3 12 11 0 1.000 1.000 1.000 510 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(8), CD44(3), CSF1(1), FCGR3A(1), IL1B(2), IL6R(1), SELL(2), SPN(3), TGFB1(1), TGFB2(4), TNF(2), TNFRSF1A(2), TNFRSF1B(3), TNFRSF8(3), TNFSF8(1) 4179333 37 29 37 16 7 10 3 11 6 0 0.898 1.000 1.000 511 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CBS(5), CTH(3), MARS(7), MARS2(1), MAT1A(4), MAT2B(1), PAPSS1(4), PAPSS2(5), SCLY(4), SEPHS1(2) 3755555 36 29 36 17 7 9 1 14 5 0 0.949 1.000 1.000 512 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(3), HK1(4), HK2(8), HK3(6), IMPA1(3), PGM1(3), PGM3(6), TGDS(1) 3153563 34 29 34 16 7 7 5 11 4 0 0.878 1.000 1.000 513 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD4(3), ICAM1(2), ITGAL(7), ITGB2(9), PTPRC(9) 3322677 32 29 31 14 9 12 2 6 3 0 0.847 1.000 1.000 514 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(3), ATP6V1D(2), ATP6V1F(2), ATP6V1G3(1), ATP6V1H(2), SHMT1(4) 4542657 39 29 39 23 11 5 3 12 8 0 0.992 1.000 1.000 515 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP3(2), CASP7(4), DFFA(2), DFFB(3), ENDOG(2), GZMB(1), HMGB2(1), TOP2A(9), TOP2B(10) 3187130 34 28 34 16 3 6 6 14 5 0 0.921 1.000 1.000 516 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(1), ALOX15(3), ALOX15B(4), ALOX5(4), DPEP1(1), LTA4H(5), PLA2G2A(1), PLA2G6(6), PTGES(1), PTGIS(2), PTGS1(3), PTGS2(2), TBXAS1(2) 4688450 35 28 35 24 11 7 1 11 5 0 1.000 1.000 1.000 517 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(1), GALNS(3), GLB1(6), GNS(2), GUSB(6), HEXA(2), HEXB(1), IDUA(4), LCT(7), NAGLU(4) 4358461 36 28 36 29 10 2 7 11 6 0 0.999 1.000 1.000 518 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(2), ASPH(4), COPS5(2), CREB1(1), EDN1(2), EP300(7), HIF1A(3), JUN(1), LDHA(1), NOS3(8), P4HB(1), VHL(1) 5089656 33 28 32 13 4 9 3 12 5 0 0.793 1.000 1.000 519 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP2A13(4), CYP2A6(6), CYP2A7(12), NAT2(3), XDH(13) 2415031 38 28 35 11 7 10 6 10 5 0 0.590 1.000 1.000 520 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(1), B3GNT2(2), B3GNT4(1), B4GALT2(2), B4GALT3(2), B4GALT4(1), FUT1(2), FUT2(1), FUT3(3), FUT5(4), FUT6(3), FUT7(2), FUT9(2), GCNT2(7), ST3GAL6(3), ST8SIA1(4) 4698173 40 28 38 15 9 8 7 11 5 0 0.723 1.000 1.000 521 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(10), CD38(2), ENPP1(4), ENPP3(8), NADSYN1(4), NMNAT1(2), NMNAT2(1), NNT(4), NT5C(1) 4388854 36 28 36 15 4 14 2 13 2 1 0.760 1.000 1.000 522 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(12), EP300(7), ESR1(4), MAPK1(3), MAPK3(1), PELP1(8), SRC(2) 4503533 37 28 37 18 7 12 4 8 6 0 0.893 1.000 1.000 523 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(4), ESR2(3), ITPKA(1), PDE1A(2), PDE1B(3), PLCB1(11), PLCB2(4), PRL(2), TRH(1), VIP(1) 3320385 32 28 32 21 7 8 3 8 6 0 0.994 1.000 1.000 524 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(3), CREBBP(12), DFFA(2), DFFB(3), GZMA(3), GZMB(1), HMGB2(1), NME1(1), PRF1(4) 3189752 30 28 30 16 4 8 4 9 5 0 0.960 1.000 1.000 525 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD8A(1), ICAM1(2), ITGAL(7), ITGB2(9), PTPRC(9) 3142804 30 28 29 11 10 10 2 5 3 0 0.652 1.000 1.000 526 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(2), DHCR7(1), FDFT1(1), FDPS(3), HMGCR(5), HMGCS1(4), IDI1(2), LSS(3), MVD(2), MVK(1), NSDHL(2), PMVK(3), SQLE(3) 3982693 32 27 32 14 3 7 4 13 4 1 0.882 1.000 1.000 527 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH1B(6), ADH5(1), ADH6(2), ADH7(3), ADHFE1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH7A1(2), ALDH9A1(2) 3999194 29 27 29 27 6 5 2 7 9 0 1.000 1.000 1.000 528 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(3), ACO1(3), ACO2(4), ACSS1(2), ACSS2(3), FH(4), IDH1(7), IDH2(5), MDH1(1), MDH2(2), SUCLA2(3) 3988208 37 27 35 14 5 3 11 14 4 0 0.698 1.000 1.000 529 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(3), IFNGR1(5), IFNGR2(2), JAK1(8), JAK2(9), STAT1(7) 2464354 34 27 34 11 5 12 2 8 7 0 0.645 1.000 1.000 530 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(2), ECHS1(2), EHHADH(14), HADHA(3), SDS(4) 3647440 39 27 39 19 7 7 6 15 4 0 0.897 1.000 1.000 531 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(3), ICAM1(2), ITGAL(7), ITGAM(7), ITGB2(9), PECAM1(1), SELE(2), SELL(2) 3225480 33 27 32 13 10 10 2 6 5 0 0.810 1.000 1.000 532 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(2), JAK1(8), JAK2(9), JAK3(5), PIAS1(1), PTPRU(3), SOAT1(3) 4237196 31 27 31 22 4 11 4 5 7 0 0.999 1.000 1.000 533 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(3), FBP1(2), FBP2(1), GOT1(2), GOT2(2), GPT(5), GPT2(3), MDH1(1), MDH2(2), ME1(1), ME2(5), ME3(1), PGK1(2), PKLR(1), RPE(1), TKT(1) 5428261 33 26 32 25 9 5 6 10 3 0 0.997 1.000 1.000 534 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(2), ACAA2(2), ACAT1(1), ACAT2(6), ECHS1(2), EHHADH(14), HADHA(3), HADHB(2), SDS(4) 2545121 36 26 36 16 7 8 6 11 4 0 0.665 1.000 1.000 535 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 8 GABRA1(5), GABRA2(4), GABRA3(3), GABRA4(8), GABRA5(4), GABRA6(6), GPX1(2) 1966853 32 26 32 13 1 7 4 13 7 0 0.867 1.000 1.000 536 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(2), ANKRD1(1), ATF3(2), DUSP14(1), EIF4E(2), EIF4EBP1(1), HBEGF(1), IFNG(3), IFRD1(3), IL18(2), IL1A(3), IL1R1(4), JUND(2), MYOG(1), NR4A3(3), WDR1(2) 3309851 33 26 32 19 6 6 3 9 9 0 0.983 1.000 1.000 537 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(7), NFKBIA(2), PLCB1(11), PRKCA(2), RELA(4) 2506940 26 26 26 10 4 6 2 9 5 0 0.793 1.000 1.000 538 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(2), PSMA2(1), PSMA4(3), PSMA5(1), PSMA6(1), PSMA7(4), PSMB1(2), PSMB2(1), PSMB3(1), PSMB5(3), PSMB6(1), PSMB7(2), PSMD14(3), RPN1(2), RPN2(2), UBE3A(4) 3987432 33 26 33 12 6 7 5 11 4 0 0.633 1.000 1.000 539 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(3), POLR2A(10), POLR2B(8), POLR2C(1), POLR2E(2), POLR2G(2), POLR2H(1), POLR2I(2), POLRMT(1) 4005828 30 26 30 18 8 7 0 8 7 0 0.990 1.000 1.000 540 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(12), C5(9), C6(2), C7(3), C8A(3), C9(3) 3838899 32 25 32 30 5 8 4 9 6 0 1.000 1.000 1.000 541 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(1), ACAT2(6), ACYP1(1), ACYP2(1), ECHS1(2), EHHADH(14), GCDH(2), HADHA(3), SDHB(3), SDS(4) 2341548 37 25 37 17 7 6 7 11 6 0 0.813 1.000 1.000 542 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), FDFT1(1), FDPS(3), HMGCR(5), IDI1(2), LSS(3), MVD(2), MVK(1), NQO1(2), NQO2(1), PMVK(3), SQLE(3), VKORC1(1) 3334343 28 25 27 16 2 3 5 12 5 1 0.989 1.000 1.000 543 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(5), CAPN1(3), CAPNS1(1), CDK5(1), CDK5R1(1), CSNK1A1(1), GSK3B(6), MAPT(12), PPP2CA(4) 2939633 34 25 34 12 12 8 2 6 6 0 0.600 1.000 1.000 544 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(9), DNAJC3(3), EIF2S1(1), EIF2S2(1), MAP3K14(2), NFKB1(7), NFKBIA(2), RELA(4) 2809495 29 25 29 14 5 4 5 8 7 0 0.881 1.000 1.000 545 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(16), GNA12(1), PRKACB(3), PRKACG(1), PRKAR2A(3), PRKAR2B(1) 3028686 25 24 24 14 6 10 0 5 3 1 0.933 1.000 1.000 546 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(3), AKR1D1(3), CYP11A1(2), CYP11B1(4), CYP11B2(9), CYP17A1(2), CYP21A2(1), HSD11B1(2), HSD3B1(1) 2733353 27 24 26 12 6 9 3 9 0 0 0.827 1.000 1.000 547 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(3), AKR1D1(3), CYP11A1(2), CYP11B1(4), CYP11B2(9), CYP17A1(2), CYP21A2(1), HSD11B1(2), HSD3B1(1) 2733353 27 24 26 12 6 9 3 9 0 0 0.827 1.000 1.000 548 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(3), B3GALNT1(3), FUT1(2), FUT2(1), FUT9(2), GBGT1(4), GLA(1), HEXA(2), HEXB(1), NAGA(2), ST3GAL1(1), ST8SIA1(4) 3143187 26 24 26 11 4 6 1 12 3 0 0.875 1.000 1.000 549 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(3), ECHS1(2), EHHADH(14), HADH(1), HADHA(3), HSD17B4(8), SIRT1(5), SIRT2(3), SIRT5(2), VNN2(2) 3573672 43 24 43 16 11 9 9 12 2 0 0.415 1.000 1.000 550 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(2), ACTR2(2), ACTR3(3), ARPC1A(2), ARPC1B(2), ARPC2(5), ARPC4(2), CDC42(2), RAC1(1), WASF1(2), WASL(2) 2471819 25 24 25 12 6 7 3 4 5 0 0.805 1.000 1.000 551 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(4), BFAR(1), BRAF(2), CAMP(1), CREB1(1), CREB3(2), CREB5(5), MAPK1(3), RAF1(2), SNX13(5), SRC(2), TERF2IP(1) 3469233 29 24 29 12 3 9 4 10 3 0 0.782 1.000 1.000 552 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(5), IARS(9), LARS(5), LARS2(2), PDHA1(1), PDHA2(4), PDHB(2) 3004322 28 24 28 12 12 6 4 5 1 0 0.501 1.000 1.000 553 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), FOS(2), JUN(1), MAPK3(1), OPRK1(2), POLR2A(10), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1) 3792377 26 23 26 10 7 3 2 9 4 1 0.827 1.000 1.000 554 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(3), FUT1(2), FUT2(1), FUT9(2), GBGT1(4), GLA(1), HEXA(2), HEXB(1), NAGA(2), ST3GAL1(1), ST3GAL4(1), ST8SIA1(4) 2965234 24 23 24 12 3 7 0 11 3 0 0.954 1.000 1.000 555 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(1), ACAT2(6), BDH1(1), BDH2(3), HMGCL(1), HMGCS1(4), HMGCS2(3), OXCT1(7) 2282873 26 23 25 13 7 6 3 6 4 0 0.810 1.000 1.000 556 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT2(2), B3GNT7(1), B4GALT2(2), B4GALT3(2), B4GALT4(1), CHST1(2), CHST2(4), CHST4(1), CHST6(2), FUT8(2), ST3GAL1(1), ST3GAL3(4), ST3GAL4(1) 3517559 25 23 25 13 10 3 3 6 3 0 0.903 1.000 1.000 557 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(3), ACO2(4), AFMID(3), CS(1), HAO1(1), HAO2(1), HYI(1), MDH1(1), MDH2(2), MTHFD1(8), MTHFD1L(5), MTHFD2(1) 4006121 31 23 31 14 5 6 4 12 4 0 0.846 1.000 1.000 558 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(1), CDK5R1(1), FYN(2), LRP8(5), RELN(12), VLDLR(3) 4182288 24 23 24 23 6 4 3 7 4 0 1.000 1.000 1.000 559 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(3), CNR2(1), DNMT1(4), MTNR1A(5), PTGDR(1), PTGER2(5), PTGER4(1), PTGFR(3), PTGIR(2) 3296599 25 23 25 12 6 5 5 6 3 0 0.789 1.000 1.000 560 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 IFNG(3), IL2(1), IL2RA(2), IL4(1), TGFB1(1), TGFB2(4), TGFB3(3), TGFBR1(5), TGFBR2(1), TGFBR3(2), TOB1(2), TOB2(1) 3235656 26 23 26 10 4 6 6 6 4 0 0.717 1.000 1.000 561 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(2), ARFGAP3(3), ARFGEF2(2), CLTB(1), COPA(5), GBF1(6), GPLD1(4), KDELR1(1), KDELR3(2) 4849749 26 22 26 14 6 6 4 7 3 0 0.934 1.000 1.000 562 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CAMK1G(3), CAMK2A(6), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(1), CAMKK1(3), CAMKK2(3), CREB1(1), SYT1(1) 3564330 26 22 26 18 7 8 1 4 6 0 0.996 1.000 1.000 563 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(1), IL4(1), JUNB(2), MAPK14(4), NFATC1(3), NFATC2(4), PRKACB(3), PRKACG(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1) 3566928 24 22 24 10 4 6 2 6 5 1 0.919 1.000 1.000 564 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(4), CCNH(3), CDC25A(2), CDC25B(4), CDC25C(1), CDK7(1), MNAT1(1), SHH(2), XPO1(7) 2591372 25 22 25 11 8 8 1 6 2 0 0.747 1.000 1.000 565 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(10), BAX(1), BCL10(1), BCL2(1), BCL2L11(1), BID(2), CASP8AP2(6), CASP9(1), CES1(3) 3494932 26 22 26 15 4 7 4 5 6 0 0.919 1.000 1.000 566 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(5), BIRC3(6), CASP8(3), FADD(2), RIPK1(6), TNF(2), TNFRSF1A(2), TNFRSF1B(3) 2468784 29 22 29 10 7 7 2 10 3 0 0.627 1.000 1.000 567 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(7), FHL5(3), FSHR(2), GNAS(9), XPO1(7) 2869972 28 21 26 14 7 4 2 12 3 0 0.974 1.000 1.000 568 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(3), ACO2(4), CS(1), HAO1(1), HAO2(1), HYI(1), MDH1(1), MDH2(2), MTHFD1(8), MTHFD1L(5), MTHFD2(1) 3819808 28 21 28 11 5 4 4 11 4 0 0.743 1.000 1.000 569 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(2), ALAS1(2), ALAS2(3), CPOX(3), FECH(2), HMBS(3), PPOX(3), UROS(3) 2342631 21 21 21 10 6 1 1 6 7 0 0.928 1.000 1.000 570 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD4(3), FYN(2), HLA-DRB1(4), LCK(5), PTPRC(9), ZAP70(3) 2729378 26 21 25 24 3 4 6 10 3 0 1.000 1.000 1.000 571 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(2), AASDH(8), AASDHPPT(2), AASS(8), KARS(1) 2072184 21 20 21 11 4 9 0 5 3 0 0.827 1.000 1.000 572 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1G(3), HDAC9(6), MEF2A(4), MEF2C(3), MEF2D(1), MYOD1(3), YWHAH(1) 2578149 21 20 21 10 4 2 3 9 3 0 0.874 1.000 1.000 573 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(2), FOSL1(1), FOSL2(1), IFNAR1(5), IFNAR2(1), IFNB1(1), NFKB1(7), RELA(4), TNFRSF11A(1), TNFSF11(1), TRAF6(1) 3234644 25 20 25 16 4 3 3 9 6 0 0.988 1.000 1.000 574 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(1), CDK5R1(1), KLK2(3), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), NGFR(1), RAF1(2) 2495683 20 19 19 12 10 3 2 4 1 0 0.948 1.000 1.000 575 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP14(4), MMP2(1), MMP9(4), RECK(7), TIMP2(1), TIMP4(3) 2251730 20 19 20 14 4 6 2 6 2 0 0.993 1.000 1.000 576 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(2), MTMR2(3), MTMR6(5), NFS1(2), PHPT1(1), TPK1(4) 1908218 18 18 18 10 3 4 2 6 3 0 0.929 1.000 1.000 577 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(3), CS(1), MDH1(1), ME1(1), PC(10), PDHA1(1), SLC25A1(1), SLC25A11(1) 2726201 19 18 19 13 1 6 5 4 3 0 0.974 1.000 1.000 578 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 9 ANPEP(5), CKM(2), EIF4E(2), FBL(2), GPT(5), LDHA(1), LDHB(2), LDHC(2), MAPK14(4) 2292525 25 18 25 12 7 7 2 5 4 0 0.891 1.000 1.000 579 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(2), CYP11A1(2), CYP11B2(9), CYP17A1(2), HSD11B1(2), HSD3B1(1) 2078906 18 17 18 12 4 5 1 7 1 0 0.976 1.000 1.000 580 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH7A1(2), ALDH9A1(2), UGDH(4) 2544514 18 17 18 10 5 4 1 6 2 0 0.917 1.000 1.000 581 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 11 CCNE1(2), CDKN1B(2), CKS1B(1), CUL1(3), E2F1(2), SKP2(3), TFDP1(3), UBE2M(2) 2040757 18 17 18 10 4 4 1 3 6 0 0.960 1.000 1.000 582 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(2), CHAT(5), CHKA(1), PCYT1A(4), PDHA1(1), PDHA2(4), PEMT(2) 2013787 19 16 19 11 5 6 2 5 1 0 0.934 1.000 1.000 583 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(3), ENO1(2), GPI(2), HK1(4), PFKL(3), PGAM1(1), PGK1(2), PKLR(1) 2753006 18 16 18 12 6 4 1 3 4 0 0.983 1.000 1.000 584 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(2), CYSLTR2(2), GPR161(4), GPR171(1), GPR18(3), GPR34(1), GPR39(1), GPR45(1), GPR65(1), GPR68(2) 2916084 18 16 18 13 4 6 0 7 1 0 0.992 1.000 1.000 585 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(5), APOBEC1(2), APOBEC2(1), APOBEC3B(2), APOBEC3F(3), APOBEC3G(1), APOBEC4(5) 2196118 19 16 17 11 2 3 4 6 4 0 0.966 1.000 1.000 586 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(2) 2377508 16 15 16 13 4 3 1 7 1 0 0.992 1.000 1.000 587 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(2) 2377508 16 15 16 13 4 3 1 7 1 0 0.992 1.000 1.000 588 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(4), CTH(3), GOT1(2), GOT2(2), LDHA(1), LDHB(2), LDHC(2) 1995922 16 15 16 12 7 5 0 4 0 0 0.973 1.000 1.000 589 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(4), GOT1(2), GOT2(2), TAT(1), TYR(6) 1399532 15 15 15 11 5 1 2 7 0 0 0.980 1.000 1.000 590 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(1), CCR3(3), CD4(3), HLA-DRB1(4), IL1B(2), IL4(1), IL5RA(2), IL6(3) 1586882 19 15 18 16 1 4 5 8 1 0 0.995 1.000 1.000 591 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(1), ACAT2(6), HMGCL(1), OXCT1(7) 1022247 15 15 14 12 5 1 2 4 3 0 0.951 1.000 1.000 592 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(2), LPL(4), NR3C1(4), PPARG(1), RXRA(6), TNF(2) 1718923 19 15 19 8 4 6 2 7 0 0 0.787 1.000 1.000 593 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT2(2), B4GALT3(2), B4GALT5(2), FUT8(2), ST3GAL1(1), ST3GAL3(4), ST3GAL4(1) 2289634 14 14 14 10 3 3 2 4 2 0 0.980 1.000 1.000 594 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(1), IL1B(2), MST1(11), MST1R(4), TNF(2) 1916599 20 14 17 17 6 1 3 7 3 0 0.999 1.000 1.000 595 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(2), RANBP2(13), RANGAP1(2) 2412768 17 14 17 10 3 4 3 5 2 0 0.863 1.000 1.000 596 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(2), F13B(2), HSD17B2(1), HSD17B3(3), HSD17B4(8), HSD17B7(2), HSD3B1(1) 2422918 19 14 19 10 4 6 1 5 3 0 0.840 1.000 1.000 597 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(5), NDUFA5(2), NDUFA8(1), NDUFB5(1), NDUFB7(1), NDUFS1(3), NDUFS2(1), NDUFV2(2) 2122068 17 14 17 10 4 4 5 4 0 0 0.890 1.000 1.000 598 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(6), ADH6(2), ADH7(3), ADHFE1(1) 1679794 14 13 14 19 2 3 1 1 7 0 1.000 1.000 1.000 599 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST1(1), HS3ST2(1), HS3ST3A1(3), XYLT1(7), XYLT2(3) 1981013 16 13 16 16 4 4 0 5 3 0 1.000 1.000 1.000 600 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST1(1), HS3ST2(1), HS3ST3A1(3), XYLT1(7), XYLT2(3) 1981013 16 13 16 16 4 4 0 5 3 0 1.000 1.000 1.000 601 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(4), SRP54(4), SRP72(6), SRPR(2) 2250077 16 13 16 10 4 3 0 4 5 0 0.985 1.000 1.000 602 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 7 CCNE1(2), CDC34(1), CUL1(3), E2F1(2), FBXW7(3), TFDP1(3) 2012843 14 12 14 10 2 4 1 3 4 0 0.994 1.000 1.000 603 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(2), FARSA(1), FARSB(1), GOT1(2), GOT2(2), PAH(1), TAT(1), YARS2(3) 2592053 13 11 13 20 3 6 1 2 1 0 1.000 1.000 1.000 604 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), ENO2(1), ENO3(1), FARS2(2), GOT1(2), GOT2(2), PAH(1), TAT(1) 2445838 12 11 12 16 4 5 1 1 1 0 1.000 1.000 1.000 605 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(2), BMPR1A(1), BMPR1B(2), BMPR2(8) 1850637 13 11 13 11 2 3 2 1 5 0 0.988 1.000 1.000 606 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(1), PARK2(1), SNCA(2), SNCAIP(2), UBE2G1(1), UBE2G2(1), UBE2L3(1), UBE2L6(1) 1852128 10 10 10 8 3 4 1 2 0 0 0.938 1.000 1.000 607 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(1), CCR3(3), CSF2(2), HLA-DRB1(4), IL3(2) 877576 12 9 11 9 2 2 5 3 0 0 0.943 1.000 1.000 608 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(3), CD80(1), HLA-DRB1(4), IL2(1), IL4(1) 1186842 10 8 9 14 0 3 3 4 0 0 1.000 1.000 1.000 609 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A2(4), BCMO1(5) 1128850 9 8 9 8 2 3 0 4 0 0 0.986 1.000 1.000 610 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(3), HLA-DRB1(4) 705454 7 5 6 12 0 2 3 2 0 0 1.000 1.000 1.000 611 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2), GOT2(2), TAT(1) 781511 5 5 5 8 2 1 1 1 0 0 0.998 1.000 1.000 612 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(1), HLCS(2), SPCS1(1), SPCS3(1) 929308 5 5 5 6 1 3 1 0 0 0 0.974 1.000 1.000 613 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(2), CD4(3) 971213 5 5 5 4 1 3 0 1 0 0 0.965 1.000 1.000 614 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C9(4) 605155 4 4 4 4 2 2 0 0 0 0 0.950 1.000 1.000 615 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 SLPI(1) 488436 1 1 1 3 0 1 0 0 0 0 0.993 1.000 1.000 616 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 347171 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000