E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.029 0.131 -9999.0 0.0 -0.617 10.0 10.0 KLHL20 -0.024 0.069 -9999.0 0.0 -0.355 3.0 3.0 CYFIP2 -0.054 0.21 -9999.0 0.0 -0.874 13.0 13.0 Rac1/GDP -0.014 0.082 -9999.0 0.0 -0.373 10.0 10.0 ENAH -0.028 0.131 -9999.0 0.0 -0.617 10.0 10.0 AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.015 0.067 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.026 0.06 -9999.0 0.0 -0.194 15.0 15.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.03 0.126 -9999.0 0.0 -0.543 12.0 12.0 RAPGEF1 0.017 0.119 -9999.0 0.0 -0.515 10.0 10.0 CTNND1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.03 0.136 -9999.0 0.0 -0.64 10.0 10.0 CRK 0.009 0.129 -9999.0 0.0 -0.569 10.0 10.0 E-cadherin/gamma catenin/alpha catenin -0.028 0.126 -9999.0 0.0 -0.592 10.0 10.0 alphaE/beta7 Integrin -0.005 0.068 -9999.0 0.0 -0.68 2.0 2.0 IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.029 0.131 -9999.0 0.0 -0.617 10.0 10.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.012 0.054 -9999.0 0.0 -0.37 1.0 1.0 MLLT4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 -0.02 0.106 -9999.0 0.0 -0.551 8.0 8.0 PI3K -0.016 0.071 -9999.0 0.0 -0.516 1.0 1.0 ARF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.032 0.144 -9999.0 0.0 -0.679 10.0 10.0 TIAM1 -0.033 0.167 -9999.0 0.0 -0.874 8.0 8.0 E-cadherin(dimer)/Ca2+ -0.024 0.109 -9999.0 0.0 -0.516 10.0 10.0 AKT1 -0.009 0.039 -9999.0 0.0 -0.258 1.0 1.0 PIK3R1 -0.004 0.06 -9999.0 0.0 -0.874 1.0 1.0 CDH1 -0.041 0.185 -9999.0 0.0 -0.874 10.0 10.0 RhoA/GDP -0.014 0.082 -9999.0 0.0 -0.374 10.0 10.0 actin cytoskeleton organization -0.017 0.05 -9999.0 0.0 -0.248 3.0 3.0 CDC42/GDP -0.014 0.082 -9999.0 0.0 -0.374 10.0 10.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.017 0.078 -9999.0 0.0 -0.366 10.0 10.0 ITGB7 -0.008 0.084 -9999.0 0.0 -0.874 2.0 2.0 RAC1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.026 0.115 -9999.0 0.0 -0.543 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.025 0.111 -9999.0 0.0 -0.523 10.0 10.0 mol:GDP 0.026 0.105 -9999.0 0.0 -0.446 10.0 10.0 CDC42/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.018 0.081 -9999.0 0.0 -0.381 10.0 10.0 RAC1/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.019 0.062 -9999.0 0.0 -0.282 10.0 10.0 NME1 0.002 0.023 0.33 1.0 -9999.0 0.0 1.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.029 0.131 -9999.0 0.0 -0.617 10.0 10.0 regulation of cell-cell adhesion -0.013 0.058 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.013 0.031 -9999.0 0.0 -0.144 1.0 1.0 Rap1/GTP -0.017 0.077 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.028 0.119 -9999.0 0.0 -0.51 12.0 12.0 CCND1 -0.024 0.079 -9999.0 0.0 -0.36 10.0 10.0 VAV2 0.011 0.124 -9999.0 0.0 -0.544 10.0 10.0 RAP1/GDP -0.017 0.077 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.028 0.126 -9999.0 0.0 -0.592 10.0 10.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.027 0.113 -9999.0 0.0 -0.486 12.0 12.0 E-cadherin/beta catenin -0.025 0.113 -9999.0 0.0 -0.533 10.0 10.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.029 0.131 -9999.0 0.0 -0.616 10.0 10.0 PIK3CA -0.004 0.06 -9999.0 0.0 -0.874 1.0 1.0 Rac1/GTP -0.04 0.117 -9999.0 0.0 -0.435 10.0 10.0 E-cadherin/beta catenin/alpha catenin -0.028 0.126 -9999.0 0.0 -0.592 10.0 10.0 ITGAE 0.002 0.023 0.33 1.0 -9999.0 0.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.031 0.14 -9999.0 0.0 -0.659 10.0 10.0