Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.072 0.242 0.552 10.0 -0.8 8.0 18.0 IHH 0.016 0.201 0.396 10.0 -0.869 8.0 18.0 SHH Np/Cholesterol/GAS1 -0.11 0.242 -9999.0 0.0 -0.601 39.0 39.0 LRPAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.109 0.24 0.595 39.0 -9999.0 0.0 39.0 SMO/beta Arrestin2 -0.004 0.226 -9999.0 0.0 -0.73 15.0 15.0 SMO -0.004 0.243 0.395 1.0 -0.78 15.0 16.0 AKT1 0.009 0.149 0.259 1.0 -0.47 8.0 9.0 ARRB2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.008 0.05 0.33 5.0 -9999.0 0.0 5.0 ADRBK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.002 0.237 0.394 1.0 -0.76 15.0 16.0 STIL 0.009 0.219 0.357 5.0 -0.568 20.0 25.0 DHH N/PTCH2 -0.001 0.052 -9999.0 0.0 -0.68 1.0 1.0 DHH N/PTCH1 0.006 0.21 0.369 2.0 -0.673 14.0 16.0 PIK3CA -0.004 0.06 -9999.0 0.0 -0.874 1.0 1.0 DHH 0.002 0.023 0.33 1.0 -9999.0 0.0 1.0 PTHLH 0.078 0.258 0.635 1.0 -0.845 8.0 9.0 determination of left/right symmetry -0.002 0.237 0.394 1.0 -0.76 15.0 16.0 PIK3R1 -0.004 0.06 -9999.0 0.0 -0.874 1.0 1.0 skeletal system development 0.079 0.257 0.634 1.0 -0.835 8.0 9.0 IHH N/Hhip -0.361 0.392 -9999.0 0.0 -0.737 108.0 108.0 DHH N/Hhip -0.332 0.343 -9999.0 0.0 -0.681 104.0 104.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.002 0.237 0.394 1.0 -0.76 15.0 16.0 pancreas development -0.426 0.438 0.329 1.0 -0.872 104.0 105.0 HHAT -0.001 0.068 0.33 2.0 -0.874 1.0 3.0 PI3K -0.006 0.084 -9999.0 0.0 -1.226 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.136 0.317 -9999.0 0.0 -0.874 33.0 33.0 somite specification -0.002 0.237 0.394 1.0 -0.76 15.0 16.0 SHH Np/Cholesterol/PTCH1 -0.015 0.22 0.337 1.0 -0.612 20.0 21.0 SHH Np/Cholesterol/PTCH2 -0.026 0.133 -9999.0 0.0 -0.599 10.0 10.0 SHH Np/Cholesterol/Megalin -0.087 0.235 -9999.0 0.0 -0.562 39.0 39.0 SHH -0.014 0.158 -9999.0 0.0 -0.742 9.0 9.0 catabolic process 0.035 0.234 0.469 1.0 -0.717 15.0 16.0 SMO/Vitamin D3 -0.009 0.247 0.436 1.0 -0.652 21.0 22.0 SHH Np/Cholesterol/Hhip -0.293 0.294 -9999.0 0.0 -0.568 110.0 110.0 LRP2 -0.099 0.326 0.33 16.0 -0.874 30.0 46.0 receptor-mediated endocytosis -0.057 0.259 -9999.0 0.0 -0.676 21.0 21.0 SHH Np/Cholesterol/BOC -0.021 0.13 -9999.0 0.0 -0.601 9.0 9.0 SHH Np/Cholesterol/CDO -0.025 0.127 -9999.0 0.0 -0.605 9.0 9.0 mesenchymal cell differentiation 0.291 0.291 0.563 110.0 -9999.0 0.0 110.0 mol:Vitamin D3 -0.005 0.23 0.436 1.0 -0.614 20.0 21.0 IHH N/PTCH2 0.002 0.14 0.28 1.0 -0.597 9.0 10.0 CDON 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.024 0.249 0.422 13.0 -0.724 15.0 28.0 Megalin/LRPAP1 -0.079 0.251 -9999.0 0.0 -0.68 30.0 30.0 PTCH2 -0.003 0.064 0.33 1.0 -0.874 1.0 2.0 SHH Np/Cholesterol -0.024 0.13 -9999.0 0.0 -0.613 9.0 9.0 PTCH1 0.035 0.236 0.47 1.0 -0.721 15.0 16.0 HHIP -0.427 0.439 0.33 1.0 -0.874 104.0 105.0