Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.017 0.076 -9999.0 0.0 -0.358 10.0 10.0 epithelial cell differentiation -0.024 0.108 -9999.0 0.0 -0.51 10.0 10.0 CYFIP2 -0.054 0.21 -9999.0 0.0 -0.874 13.0 13.0 ENAH 0.025 0.113 -9999.0 0.0 -0.514 4.0 4.0 EGFR -0.012 0.103 -9999.0 0.0 -0.874 3.0 3.0 EPHA2 -0.037 0.176 -9999.0 0.0 -0.874 9.0 9.0 MYO6 -0.023 0.103 -9999.0 0.0 -0.486 10.0 10.0 CTNNB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.036 0.142 -9999.0 0.0 -0.593 13.0 13.0 AQP5 -0.015 0.09 -9999.0 0.0 -0.424 8.0 8.0 CTNND1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.022 0.101 -9999.0 0.0 -0.477 10.0 10.0 regulation of calcium-dependent cell-cell adhesion -0.012 0.121 -9999.0 0.0 -0.477 11.0 11.0 EGF 0.084 0.144 0.33 54.0 -9999.0 0.0 54.0 NCKAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.07 0.199 -9999.0 0.0 -0.594 25.0 25.0 cortical microtubule organization -0.024 0.108 -9999.0 0.0 -0.51 10.0 10.0 GO:0000145 -0.021 0.096 -9999.0 0.0 -0.454 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.024 0.109 -9999.0 0.0 -0.516 10.0 10.0 MLLT4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.04 0.143 -9999.0 0.0 -0.795 4.0 4.0 ARF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.028 0.12 -9999.0 0.0 -0.543 11.0 11.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.021 0.095 -9999.0 0.0 -0.449 10.0 10.0 PVRL2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.023 0.103 -9999.0 0.0 -0.486 10.0 10.0 ARF6/GTP -0.026 0.111 -9999.0 0.0 -0.501 11.0 11.0 CDH1 -0.041 0.185 -9999.0 0.0 -0.874 10.0 10.0 EGFR/EGFR/EGF/EGF 0.001 0.143 -9999.0 0.0 -0.545 11.0 11.0 RhoA/GDP -0.023 0.102 -9999.0 0.0 -0.479 10.0 10.0 actin cytoskeleton organization -0.021 0.096 -9999.0 0.0 -0.454 10.0 10.0 IGF-1R heterotetramer -0.005 0.09 0.329 2.0 -0.872 2.0 4.0 GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.005 0.091 0.33 2.0 -0.874 2.0 4.0 IGF1 -0.359 0.43 -9999.0 0.0 -0.874 87.0 87.0 DIAPH1 -0.051 0.179 -9999.0 0.0 -0.722 14.0 14.0 Wnt receptor signaling pathway 0.024 0.108 0.51 10.0 -9999.0 0.0 10.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.04 0.143 -9999.0 0.0 -0.796 4.0 4.0 CTNNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.022 0.099 -9999.0 0.0 -0.467 10.0 10.0 EFNA1 -0.008 0.084 -9999.0 0.0 -0.874 2.0 2.0 LPP -0.022 0.097 -9999.0 0.0 -0.457 10.0 10.0 Ephrin A1/EPHA2 -0.046 0.167 -9999.0 0.0 -0.579 17.0 17.0 SEC6/SEC8 -0.02 0.091 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.012 0.123 -9999.0 0.0 -0.486 11.0 11.0 HGF/MET -0.251 0.269 -9999.0 0.0 -0.507 105.0 105.0 HGF -0.42 0.437 -9999.0 0.0 -0.874 102.0 102.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.017 0.076 -9999.0 0.0 -0.361 10.0 10.0 actin cable formation 0.032 0.103 -9999.0 0.0 -0.4 6.0 6.0 KIAA1543 -0.033 0.142 -9999.0 0.0 -0.576 12.0 12.0 KIFC3 -0.023 0.103 -9999.0 0.0 -0.486 10.0 10.0 NCK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.023 0.103 -9999.0 0.0 -0.486 10.0 10.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.024 0.108 -9999.0 0.0 -0.51 10.0 10.0 EXOC4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.023 0.103 -9999.0 0.0 -0.486 10.0 10.0 PIP5K1C -0.023 0.103 -9999.0 0.0 -0.486 10.0 10.0 LIMA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.034 0.12 -9999.0 0.0 -0.648 4.0 4.0 adherens junction assembly 0.015 0.143 -9999.0 0.0 -0.764 4.0 4.0 IGF-1R heterotetramer/IGF1 -0.22 0.248 -9999.0 0.0 -0.486 96.0 96.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.003 0.064 0.33 1.0 -0.874 1.0 2.0 PLEKHA7 -0.028 0.113 -9999.0 0.0 -0.487 12.0 12.0 mol:GTP -0.028 0.119 -9999.0 0.0 -0.538 11.0 11.0 establishment of epithelial cell apical/basal polarity -0.019 0.087 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.017 0.076 -9999.0 0.0 -0.358 10.0 10.0 regulation of cell-cell adhesion -0.021 0.096 -9999.0 0.0 -0.454 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.017 0.076 -9999.0 0.0 -0.361 10.0 10.0