E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.022 0.131 -9999.0 0.0 -0.515 9.0 9.0 KLHL20 -0.007 0.083 -9999.0 0.0 -0.273 6.0 6.0 CYFIP2 -0.013 0.152 -9999.0 0.0 -0.624 12.0 12.0 Rac1/GDP -0.001 0.089 -9999.0 0.0 -0.318 9.0 9.0 ENAH -0.009 0.115 -9999.0 0.0 -0.515 7.0 7.0 AP1M1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.009 0.065 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.03 0.058 -9999.0 0.0 -0.193 10.0 10.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.03 0.103 -9999.0 0.0 -0.369 12.0 12.0 RAPGEF1 -0.022 0.119 -9999.0 0.0 -0.449 10.0 10.0 CTNND1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.02 0.14 -9999.0 0.0 -0.528 10.0 10.0 CRK -0.017 0.118 -9999.0 0.0 -0.485 10.0 10.0 E-cadherin/gamma catenin/alpha catenin 0.025 0.098 -9999.0 0.0 -0.404 10.0 10.0 alphaE/beta7 Integrin 0.029 0.052 0.251 1.0 -0.458 2.0 3.0 IQGAP1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.043 0.017 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.023 0.134 -9999.0 0.0 -0.515 10.0 10.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.008 0.047 -9999.0 0.0 -0.245 1.0 1.0 MLLT4 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.03 0.083 -9999.0 0.0 -0.369 8.0 8.0 PI3K -0.006 0.062 -9999.0 0.0 -0.322 1.0 1.0 ARF6 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.01 0.109 -9999.0 0.0 -0.467 10.0 10.0 TIAM1 -0.0 0.126 -9999.0 0.0 -0.624 8.0 8.0 E-cadherin(dimer)/Ca2+ 0.035 0.089 -9999.0 0.0 -0.351 10.0 10.0 AKT1 -0.009 0.039 -9999.0 0.0 -0.182 1.0 1.0 PIK3R1 0.022 0.045 -9999.0 0.0 -0.624 1.0 1.0 CDH1 -0.008 0.14 -9999.0 0.0 -0.624 10.0 10.0 RhoA/GDP -0.002 0.092 -9999.0 0.0 -0.318 10.0 10.0 actin cytoskeleton organization -0.003 0.062 -9999.0 0.0 -0.196 6.0 6.0 CDC42/GDP 0.002 0.09 -9999.0 0.0 -0.318 10.0 10.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.003 0.066 -9999.0 0.0 -0.285 10.0 10.0 ITGB7 0.019 0.064 -9999.0 0.0 -0.624 2.0 2.0 RAC1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.039 0.095 -9999.0 0.0 -0.372 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.023 0.085 -9999.0 0.0 -0.349 10.0 10.0 mol:GDP -0.016 0.1 -9999.0 0.0 -0.368 10.0 10.0 CDC42/GTP/IQGAP1 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.004 0.096 -9999.0 0.0 -0.326 10.0 10.0 RAC1/GTP/IQGAP1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.037 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.007 0.066 0.209 1.0 -0.249 10.0 11.0 NME1 0.027 0.023 0.347 1.0 -9999.0 0.0 1.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.023 0.134 -9999.0 0.0 -0.515 10.0 10.0 regulation of cell-cell adhesion 0.003 0.055 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.004 0.039 -9999.0 0.0 -0.139 1.0 1.0 Rap1/GTP 0.011 0.075 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.038 0.101 -9999.0 0.0 -0.351 12.0 12.0 CCND1 -0.009 0.082 0.237 1.0 -0.315 10.0 11.0 VAV2 -0.033 0.173 -9999.0 0.0 -0.567 9.0 9.0 RAP1/GDP 0.009 0.08 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.021 0.13 -9999.0 0.0 -0.497 10.0 10.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.026 0.094 -9999.0 0.0 -0.339 12.0 12.0 E-cadherin/beta catenin -0.009 0.092 -9999.0 0.0 -0.416 10.0 10.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.024 0.136 -9999.0 0.0 -0.515 10.0 10.0 PIK3CA 0.022 0.045 -9999.0 0.0 -0.624 1.0 1.0 Rac1/GTP -0.039 0.132 -9999.0 0.0 -0.478 9.0 9.0 E-cadherin/beta catenin/alpha catenin 0.026 0.098 -9999.0 0.0 -0.404 10.0 10.0 ITGAE 0.024 0.024 0.347 1.0 -9999.0 0.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.02 0.143 -9999.0 0.0 -0.541 10.0 10.0