Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.008 0.065 -9999.0 0.0 -0.278 10.0 10.0 epithelial cell differentiation 0.031 0.087 -9999.0 0.0 -0.348 10.0 10.0 CYFIP2 -0.013 0.152 -9999.0 0.0 -0.624 12.0 12.0 ENAH -0.012 0.082 0.262 2.0 -0.409 3.0 5.0 EGFR 0.015 0.078 -9999.0 0.0 -0.624 3.0 3.0 EPHA2 0.001 0.12 -9999.0 0.0 -0.585 8.0 8.0 MYO6 -0.005 0.078 -9999.0 0.0 -0.336 10.0 10.0 CTNNB1 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.026 0.101 -9999.0 0.0 -0.404 10.0 10.0 AQP5 0.004 0.068 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.004 0.077 -9999.0 0.0 -0.331 10.0 10.0 regulation of calcium-dependent cell-cell adhesion 0.006 0.094 -9999.0 0.0 -0.332 11.0 11.0 EGF 0.1 0.141 0.347 50.0 -9999.0 0.0 50.0 NCKAP1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.049 0.17 -9999.0 0.0 -0.567 16.0 16.0 cortical microtubule organization 0.031 0.087 -9999.0 0.0 -0.348 10.0 10.0 GO:0000145 -0.021 0.07 -9999.0 0.0 -0.316 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.035 0.089 -9999.0 0.0 -0.351 10.0 10.0 MLLT4 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.035 0.091 -9999.0 0.0 -0.388 11.0 11.0 ARF6 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.033 0.081 -9999.0 0.0 -0.372 6.0 6.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.007 0.071 -9999.0 0.0 -0.308 10.0 10.0 PVRL2 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.004 0.078 -9999.0 0.0 -0.336 10.0 10.0 ARF6/GTP 0.038 0.079 -9999.0 0.0 -0.349 6.0 6.0 CDH1 -0.008 0.14 -9999.0 0.0 -0.624 10.0 10.0 EGFR/EGFR/EGF/EGF 0.044 0.111 -9999.0 0.0 -0.394 8.0 8.0 RhoA/GDP 0.032 0.084 -9999.0 0.0 -0.333 10.0 10.0 actin cytoskeleton organization -0.02 0.07 -9999.0 0.0 -0.327 9.0 9.0 IGF-1R heterotetramer 0.022 0.072 0.346 2.0 -0.623 2.0 4.0 GIT1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.022 0.072 0.347 2.0 -0.624 2.0 4.0 IGF1 -0.244 0.32 -9999.0 0.0 -0.624 85.0 85.0 DIAPH1 -0.007 0.173 -9999.0 0.0 -0.625 14.0 14.0 Wnt receptor signaling pathway -0.031 0.087 0.348 10.0 -9999.0 0.0 10.0 RHOA 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.035 0.091 -9999.0 0.0 -0.389 11.0 11.0 CTNNA1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.021 0.071 -9999.0 0.0 -0.334 9.0 9.0 EFNA1 0.013 0.064 -9999.0 0.0 -0.624 2.0 2.0 LPP -0.022 0.072 -9999.0 0.0 -0.323 10.0 10.0 Ephrin A1/EPHA2 0.008 0.113 -9999.0 0.0 -0.424 11.0 11.0 SEC6/SEC8 -0.026 0.066 -9999.0 0.0 -0.315 10.0 10.0 MGAT3 0.006 0.095 -9999.0 0.0 -0.337 11.0 11.0 HGF/MET -0.144 0.206 -9999.0 0.0 -0.355 95.0 95.0 HGF -0.275 0.322 -9999.0 0.0 -0.621 95.0 95.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.008 0.066 -9999.0 0.0 -0.279 10.0 10.0 actin cable formation 0.03 0.112 0.35 5.0 -0.323 3.0 8.0 KIAA1543 -0.024 0.074 -9999.0 0.0 -0.322 11.0 11.0 KIFC3 -0.005 0.078 -9999.0 0.0 -0.336 10.0 10.0 NCK1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.004 0.078 -9999.0 0.0 -0.336 10.0 10.0 NCK1/GIT1 0.038 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.031 0.087 -9999.0 0.0 -0.348 10.0 10.0 EXOC4 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.004 0.078 -9999.0 0.0 -0.336 10.0 10.0 PIP5K1C -0.004 0.078 -9999.0 0.0 -0.336 10.0 10.0 LIMA1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.004 0.118 0.344 3.0 -0.465 4.0 7.0 adherens junction assembly -0.021 0.083 -9999.0 0.0 -0.375 1.0 1.0 IGF-1R heterotetramer/IGF1 -0.128 0.194 -9999.0 0.0 -0.339 90.0 90.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.034 0.012 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.021 0.046 -9999.0 0.0 -0.624 1.0 1.0 PLEKHA7 -0.007 0.081 -9999.0 0.0 -0.337 11.0 11.0 mol:GTP 0.031 0.08 -9999.0 0.0 -0.37 6.0 6.0 establishment of epithelial cell apical/basal polarity -0.009 0.09 0.318 3.0 -9999.0 0.0 3.0 cortical actin cytoskeleton stabilization 0.008 0.065 -9999.0 0.0 -0.278 10.0 10.0 regulation of cell-cell adhesion -0.02 0.07 -9999.0 0.0 -0.327 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.008 0.066 -9999.0 0.0 -0.279 10.0 10.0