Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.209 0.247 -9999.0 0.0 -0.649 85.0 85.0 IHH -0.306 0.27 -9999.0 0.0 -0.54 276.0 276.0 SHH Np/Cholesterol/GAS1 -0.04 0.101 -9999.0 0.0 -0.278 71.0 71.0 LRPAP1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.04 0.1 0.276 71.0 -9999.0 0.0 71.0 SMO/beta Arrestin2 -0.208 0.214 -9999.0 0.0 -0.503 97.0 97.0 SMO -0.224 0.226 -9999.0 0.0 -0.528 100.0 100.0 AKT1 -0.092 0.106 -9999.0 0.0 -0.26 46.0 46.0 ARRB2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.008 0.033 -9999.0 0.0 -0.508 2.0 2.0 ADRBK1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.221 0.222 -9999.0 0.0 -0.519 100.0 100.0 STIL -0.193 0.216 -9999.0 0.0 -0.518 109.0 109.0 DHH N/PTCH2 -0.029 0.097 -9999.0 0.0 -0.352 40.0 40.0 DHH N/PTCH1 -0.191 0.194 -9999.0 0.0 -0.489 93.0 93.0 PIK3CA 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.031 0.138 -9999.0 0.0 -0.499 39.0 39.0 PTHLH -0.273 0.287 -9999.0 0.0 -0.77 85.0 85.0 determination of left/right symmetry -0.221 0.222 -9999.0 0.0 -0.519 100.0 100.0 PIK3R1 0.009 0.023 -9999.0 0.0 -0.499 1.0 1.0 skeletal system development -0.27 0.284 -9999.0 0.0 -0.761 85.0 85.0 IHH N/Hhip -0.369 0.256 -9999.0 0.0 -0.493 368.0 368.0 DHH N/Hhip -0.219 0.2 -9999.0 0.0 -0.381 280.0 280.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.221 0.222 -9999.0 0.0 -0.519 100.0 100.0 pancreas development -0.269 0.252 -9999.0 0.0 -0.498 268.0 268.0 HHAT 0.008 0.032 -9999.0 0.0 -0.499 2.0 2.0 PI3K -0.001 0.016 -9999.0 0.0 -0.352 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.004 0.082 -9999.0 0.0 -0.499 13.0 13.0 somite specification -0.221 0.222 -9999.0 0.0 -0.519 100.0 100.0 SHH Np/Cholesterol/PTCH1 -0.174 0.194 -9999.0 0.0 -0.464 105.0 105.0 SHH Np/Cholesterol/PTCH2 -0.034 0.088 -9999.0 0.0 -0.263 63.0 63.0 SHH Np/Cholesterol/Megalin -0.104 0.148 -9999.0 0.0 -0.292 173.0 173.0 SHH -0.029 0.123 -9999.0 0.0 -0.352 62.0 62.0 catabolic process -0.197 0.199 -9999.0 0.0 -0.506 79.0 79.0 SMO/Vitamin D3 -0.198 0.214 -9999.0 0.0 -0.506 105.0 105.0 SHH Np/Cholesterol/Hhip -0.178 0.164 -9999.0 0.0 -0.302 288.0 288.0 LRP2 -0.126 0.225 -9999.0 0.0 -0.499 130.0 130.0 receptor-mediated endocytosis -0.254 0.225 -9999.0 0.0 -0.522 161.0 161.0 SHH Np/Cholesterol/BOC -0.035 0.089 -9999.0 0.0 -0.263 64.0 64.0 SHH Np/Cholesterol/CDO -0.039 0.097 -9999.0 0.0 -0.27 71.0 71.0 mesenchymal cell differentiation 0.177 0.163 0.3 288.0 -9999.0 0.0 288.0 mol:Vitamin D3 -0.175 0.196 -9999.0 0.0 -0.466 105.0 105.0 IHH N/PTCH2 -0.175 0.165 -9999.0 0.0 -0.317 276.0 276.0 CDON -0.002 0.075 -9999.0 0.0 -0.499 11.0 11.0 IHH N/PTCH1 -0.199 0.201 -9999.0 0.0 -0.512 79.0 79.0 Megalin/LRPAP1 -0.094 0.155 -9999.0 0.0 -0.352 130.0 130.0 PTCH2 0.009 0.023 -9999.0 0.0 -0.499 1.0 1.0 SHH Np/Cholesterol -0.034 0.09 -9999.0 0.0 -0.27 62.0 62.0 PTCH1 -0.198 0.2 -9999.0 0.0 -0.508 79.0 79.0 HHIP -0.27 0.253 -9999.0 0.0 -0.499 268.0 268.0