E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.006 0.07 -9999.0 0.0 -0.305 23.0 23.0 KLHL20 -0.002 0.053 0.164 2.0 -0.202 14.0 16.0 CYFIP2 0.016 0.041 -9999.0 0.0 -0.321 7.0 7.0 Rac1/GDP -0.011 0.061 0.304 4.0 -0.253 8.0 12.0 ENAH -0.006 0.071 -9999.0 0.0 -0.306 24.0 24.0 AP1M1 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.026 0.022 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.015 0.028 -9999.0 0.0 -0.135 18.0 18.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.046 0.026 -9999.0 0.0 -0.172 3.0 3.0 RAPGEF1 -0.01 0.059 0.213 2.0 -0.281 14.0 16.0 CTNND1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.001 0.073 -9999.0 0.0 -0.312 24.0 24.0 CRK -0.01 0.053 -9999.0 0.0 -0.295 14.0 14.0 E-cadherin/gamma catenin/alpha catenin 0.039 0.019 -9999.0 0.0 -0.193 2.0 2.0 alphaE/beta7 Integrin 0.028 0.015 -9999.0 0.0 -0.226 1.0 1.0 IQGAP1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.034 0.016 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.004 0.067 -9999.0 0.0 -0.309 21.0 21.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.025 0.015 -9999.0 0.0 -0.13 2.0 2.0 MLLT4 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.049 0.054 0.21 40.0 -0.169 5.0 45.0 PI3K -0.03 0.019 -9999.0 0.0 -0.164 2.0 2.0 ARF6 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.029 0.018 -9999.0 0.0 -0.226 2.0 2.0 TIAM1 0.016 0.038 -9999.0 0.0 -0.321 6.0 6.0 E-cadherin(dimer)/Ca2+ 0.045 0.02 -9999.0 0.0 -0.157 2.0 2.0 AKT1 -0.017 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.02 0.016 -9999.0 0.0 -0.321 1.0 1.0 CDH1 0.019 0.022 -9999.0 0.0 -0.321 2.0 2.0 RhoA/GDP -0.012 0.063 0.304 4.0 -0.249 8.0 12.0 actin cytoskeleton organization 0.002 0.046 0.165 10.0 -0.152 12.0 22.0 CDC42/GDP -0.012 0.063 0.304 4.0 -0.254 9.0 13.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.009 0.013 -9999.0 0.0 -0.186 2.0 2.0 ITGB7 0.02 0.016 -9999.0 0.0 -0.321 1.0 1.0 RAC1 0.019 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.049 0.021 -9999.0 0.0 -0.168 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.034 0.016 -9999.0 0.0 -0.152 2.0 2.0 mol:GDP -0.012 0.069 0.317 4.0 -0.289 9.0 13.0 CDC42/GTP/IQGAP1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.004 0.06 0.228 2.0 -0.25 6.0 8.0 RAC1/GTP/IQGAP1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.006 0.037 0.133 12.0 -0.119 13.0 25.0 NME1 0.048 0.086 0.319 44.0 -9999.0 0.0 44.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.0 0.057 -9999.0 0.0 -0.305 14.0 14.0 regulation of cell-cell adhesion -0.024 0.018 -9999.0 0.0 -0.148 2.0 2.0 WASF2 -0.004 0.023 -9999.0 0.0 -0.088 4.0 4.0 Rap1/GTP -0.023 0.029 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.051 0.031 -9999.0 0.0 -0.172 3.0 3.0 CCND1 0.007 0.043 0.145 11.0 -0.145 13.0 24.0 VAV2 -0.011 0.129 -9999.0 0.0 -0.567 20.0 20.0 RAP1/GDP -0.019 0.044 0.195 1.0 -0.226 4.0 5.0 adherens junction assembly 0.0 0.055 -9999.0 0.0 -0.297 14.0 14.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.036 0.026 -9999.0 0.0 -0.164 3.0 3.0 E-cadherin/beta catenin 0.004 0.02 -9999.0 0.0 -0.275 2.0 2.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.006 0.07 -9999.0 0.0 -0.306 23.0 23.0 PIK3CA 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.007 0.068 -9999.0 0.0 -0.306 19.0 19.0 E-cadherin/beta catenin/alpha catenin 0.039 0.019 -9999.0 0.0 -0.182 2.0 2.0 ITGAE 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.001 0.075 -9999.0 0.0 -0.318 24.0 24.0