Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	8.0	444.0	51.0	-0.74	0.019	1000.0	-1000.0	-0.176	-1000.0
HIF-1-alpha transcription factor network	7.0	559.0	76.0	-0.776	0.028	1000.0	-1000.0	-0.114	-1000.0
TCGA08_retinoblastoma	7.0	59.0	8.0	-0.246	0.092	1000.0	-1000.0	-0.023	-1000.0
IL23-mediated signaling events	5.0	342.0	60.0	-0.635	0.017	1000.0	-1000.0	-0.16	-1000.0
Osteopontin-mediated events	4.0	184.0	38.0	-0.425	0.016	1000.0	-1000.0	-0.139	-1000.0
Signaling events mediated by the Hedgehog family	4.0	208.0	52.0	-0.35	0.212	1000.0	-1000.0	-0.102	-1000.0
IL4-mediated signaling events	4.0	420.0	91.0	-0.83	0.671	1000.0	-1000.0	-0.144	-1000.0
Fc-epsilon receptor I signaling in mast cells	4.0	398.0	97.0	-0.361	0.053	1000.0	-1000.0	-0.107	-1000.0
Endothelins	4.0	438.0	96.0	-0.385	0.016	1000.0	-1000.0	-0.081	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	4.0	281.0	68.0	-0.605	0.175	1000.0	-1000.0	-0.145	-1000.0
IL12-mediated signaling events	3.0	264.0	87.0	-0.297	0.016	1000.0	-1000.0	-0.129	-1000.0
PLK2 and PLK4 events	3.0	10.0	3.0	-0.092	0.016	1000.0	-1000.0	-0.015	-1000.0
Visual signal transduction: Cones	3.0	117.0	38.0	-0.249	0.016	1000.0	-1000.0	-0.082	-1000.0
Syndecan-2-mediated signaling events	3.0	224.0	69.0	-0.291	0.041	1000.0	-1000.0	-0.07	-1000.0
amb2 Integrin signaling	3.0	260.0	82.0	-0.25	0.016	1000.0	-1000.0	-0.102	-1000.0
Ephrin B reverse signaling	3.0	171.0	48.0	-0.246	0.116	1000.0	-1000.0	-0.092	-1000.0
Calcium signaling in the CD4+ TCR pathway	3.0	105.0	31.0	-0.357	0.026	1000.0	-1000.0	-0.092	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	378.0	125.0	-0.225	0.016	1000.0	-1000.0	-0.127	-1000.0
IL27-mediated signaling events	3.0	185.0	51.0	-0.324	0.157	1000.0	-1000.0	-0.098	-1000.0
Wnt signaling	3.0	22.0	7.0	-0.201	0.016	1000.0	-1000.0	-0.042	-1000.0
BCR signaling pathway	3.0	310.0	99.0	-0.27	0.051	1000.0	-1000.0	-0.112	-1000.0
EGFR-dependent Endothelin signaling events	3.0	77.0	21.0	-0.257	0.016	1000.0	-1000.0	-0.102	-1000.0
Syndecan-1-mediated signaling events	2.0	89.0	34.0	-0.324	0.016	1000.0	-1000.0	-0.075	-1000.0
Noncanonical Wnt signaling pathway	2.0	52.0	26.0	-0.201	0.016	1000.0	-1000.0	-0.11	-1000.0
Arf6 signaling events	2.0	167.0	62.0	-0.233	0.021	1000.0	-1000.0	-0.068	-1000.0
FOXA2 and FOXA3 transcription factor networks	2.0	102.0	46.0	-0.332	0.026	1000.0	-1000.0	-0.067	-1000.0
BMP receptor signaling	2.0	232.0	81.0	-0.412	0.04	1000.0	-1000.0	-0.13	-1000.0
Nectin adhesion pathway	2.0	166.0	63.0	-0.207	0.016	1000.0	-1000.0	-0.088	-1000.0
Glucocorticoid receptor regulatory network	2.0	266.0	114.0	-0.524	0.116	1000.0	-1000.0	-0.08	-1000.0
IL1-mediated signaling events	2.0	154.0	62.0	-0.215	0.074	1000.0	-1000.0	-0.112	-1000.0
TCGA08_p53	2.0	20.0	7.0	-0.188	0.084	1000.0	-1000.0	-0.019	-1000.0
Syndecan-3-mediated signaling events	2.0	97.0	35.0	-0.291	0.016	1000.0	-1000.0	-0.089	-1000.0
Signaling mediated by p38-alpha and p38-beta	2.0	106.0	44.0	-0.207	0.016	1000.0	-1000.0	-0.058	-1000.0
Integrins in angiogenesis	2.0	221.0	84.0	-0.266	0.016	1000.0	-1000.0	-0.116	-1000.0
Glypican 2 network	2.0	9.0	4.0	-0.058	0.0	1000.0	-1000.0	-0.027	-1000.0
IL6-mediated signaling events	2.0	170.0	75.0	-0.533	0.047	1000.0	-1000.0	-0.1	-1000.0
Plasma membrane estrogen receptor signaling	2.0	216.0	86.0	-0.235	0.126	1000.0	-1000.0	-0.112	-1000.0
Visual signal transduction: Rods	2.0	152.0	52.0	-0.341	0.016	1000.0	-1000.0	-0.118	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	2.0	203.0	78.0	-0.179	0.072	1000.0	-1000.0	-0.094	-1000.0
Caspase cascade in apoptosis	1.0	137.0	74.0	-0.133	0.067	1000.0	-1000.0	-0.059	-1000.0
Coregulation of Androgen receptor activity	1.0	91.0	76.0	-0.25	0.047	1000.0	-1000.0	-0.046	-1000.0
ErbB4 signaling events	1.0	91.0	69.0	-0.508	0.11	1000.0	-1000.0	-0.111	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	37.0	28.0	-0.076	0.016	1000.0	-1000.0	-0.056	-1000.0
Ephrin A  reverse signaling	1.0	9.0	7.0	-0.026	0.007	1000.0	-1000.0	-0.044	-1000.0
Thromboxane A2 receptor signaling	1.0	208.0	105.0	-0.175	0.027	1000.0	-1000.0	-0.1	-1000.0
Cellular roles of Anthrax toxin	1.0	68.0	39.0	-0.081	0.016	1000.0	-1000.0	-0.04	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	156.0	85.0	-0.131	0.016	1000.0	-1000.0	-0.091	-1000.0
Signaling events mediated by PTP1B	1.0	130.0	76.0	-0.223	0.092	1000.0	-1000.0	-0.1	-1000.0
Presenilin action in Notch and Wnt signaling	1.0	77.0	61.0	-0.275	0.039	1000.0	-1000.0	-0.089	-1000.0
Glypican 1 network	1.0	70.0	48.0	-0.078	0.025	1000.0	-1000.0	-0.067	-1000.0
PLK1 signaling events	1.0	97.0	85.0	-0.162	0.025	1000.0	-1000.0	-0.06	-1000.0
mTOR signaling pathway	1.0	78.0	53.0	-0.091	0.034	1000.0	-1000.0	-0.079	-1000.0
Ceramide signaling pathway	1.0	90.0	76.0	-0.133	0.052	1000.0	-1000.0	-0.071	-1000.0
Reelin signaling pathway	1.0	71.0	56.0	-0.104	0.024	1000.0	-1000.0	-0.1	-1000.0
TRAIL signaling pathway	1.0	90.0	48.0	-0.085	0.021	1000.0	-1000.0	-0.098	-1000.0
Signaling events regulated by Ret tyrosine kinase	1.0	83.0	82.0	-0.104	0.022	1000.0	-1000.0	-0.109	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	63.0	52.0	-0.158	0.027	1000.0	-1000.0	-0.078	-1000.0
HIF-2-alpha transcription factor network	1.0	76.0	43.0	-0.293	0.154	1000.0	-1000.0	-0.093	-1000.0
S1P1 pathway	1.0	71.0	36.0	-0.202	0.016	1000.0	-1000.0	-0.084	-1000.0
FAS signaling pathway (CD95)	1.0	91.0	47.0	-0.235	0.028	1000.0	-1000.0	-0.063	-1000.0
TCR signaling in naïve CD8+ T cells	1.0	171.0	93.0	-0.145	0.022	1000.0	-1000.0	-0.096	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	52.0	45.0	-0.131	0.039	1000.0	-1000.0	-0.113	-1000.0
Canonical Wnt signaling pathway	1.0	70.0	51.0	-0.275	0.069	1000.0	-1000.0	-0.07	-1000.0
EPHB forward signaling	1.0	166.0	85.0	-0.164	0.134	1000.0	-1000.0	-0.121	-1000.0
Effects of Botulinum toxin	1.0	38.0	26.0	-0.11	0.016	1000.0	-1000.0	-0.079	-1000.0
Nongenotropic Androgen signaling	1.0	53.0	52.0	-0.033	0.027	1000.0	-1000.0	-0.077	-1000.0
TCGA08_rtk_signaling	1.0	38.0	26.0	-0.175	0.029	1000.0	-1000.0	-0.031	-1000.0
LPA receptor mediated events	1.0	158.0	102.0	-0.259	0.016	1000.0	-1000.0	-0.087	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	1.0	107.0	74.0	-0.183	0.04	1000.0	-1000.0	-0.104	-1000.0
Regulation of Telomerase	1.0	119.0	102.0	-0.234	0.054	1000.0	-1000.0	-0.124	-1000.0
Syndecan-4-mediated signaling events	1.0	133.0	67.0	-0.158	0.018	1000.0	-1000.0	-0.116	-1000.0
Insulin Pathway	1.0	117.0	74.0	-0.216	0.019	1000.0	-1000.0	-0.122	-1000.0
VEGFR1 specific signals	1.0	63.0	56.0	-0.066	0.016	1000.0	-1000.0	-0.107	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	47.0	33.0	-0.292	0.033	1000.0	-1000.0	-0.089	-1000.0
Signaling events mediated by PRL	1.0	45.0	34.0	-0.172	0.029	1000.0	-1000.0	-0.054	-1000.0
E-cadherin signaling in keratinocytes	1.0	55.0	43.0	-0.175	0.03	1000.0	-1000.0	-0.088	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.001	-1000.0	1000.0	-1000.0	-0.02	-1000.0
E-cadherin signaling events	1.0	9.0	5.0	-0.05	-0.001	1000.0	-1000.0	-0.056	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	22.0	17.0	-0.03	0.016	1000.0	-1000.0	-0.043	-1000.0
Aurora B signaling	1.0	109.0	67.0	-0.163	0.016	1000.0	-1000.0	-0.089	-1000.0
LPA4-mediated signaling events	0.0	7.0	12.0	0.0	0.026	1000.0	-1000.0	-0.024	-1000.0
ErbB2/ErbB3 signaling events	0.0	22.0	65.0	-0.025	0.057	1000.0	-1000.0	-0.085	-1000.0
Regulation of nuclear SMAD2/3 signaling	0.0	122.0	136.0	-0.231	0.2	1000.0	-1000.0	-0.093	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	8.0	23.0	-0.025	0.047	1000.0	-1000.0	-0.098	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	0.0	5.0	34.0	-0.093	0.043	1000.0	-1000.0	-0.088	-1000.0
Canonical NF-kappaB pathway	0.0	19.0	39.0	-0.071	0.075	1000.0	-1000.0	-0.112	-1000.0
Signaling events mediated by HDAC Class II	0.0	44.0	75.0	-0.235	0.038	1000.0	-1000.0	-0.083	-1000.0
BARD1 signaling events	0.0	30.0	57.0	-0.052	0.047	1000.0	-1000.0	-0.1	-1000.0
Circadian rhythm pathway	0.0	15.0	22.0	-0.175	0.054	1000.0	-1000.0	-0.058	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	0.0	28.0	54.0	-0.065	0.033	1000.0	-1000.0	-0.125	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	8.0	17.0	-0.014	0.037	1000.0	-1000.0	-0.082	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.0	0.016	1000.0	-1000.0	-0.049	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	60.0	65.0	-0.321	0.055	1000.0	-1000.0	-0.073	-1000.0
Aurora A signaling	0.0	45.0	60.0	-0.119	0.041	1000.0	-1000.0	-0.081	-1000.0
p75(NTR)-mediated signaling	0.0	124.0	125.0	-0.307	0.04	1000.0	-1000.0	-0.122	-1000.0
Arf6 downstream pathway	0.0	17.0	43.0	-0.028	0.021	1000.0	-1000.0	-0.048	-1000.0
Aurora C signaling	0.0	5.0	7.0	-0.052	0.0	1000.0	-1000.0	-0.054	-1000.0
EPO signaling pathway	0.0	22.0	55.0	-0.047	0.07	1000.0	-1000.0	-0.117	-1000.0
Insulin-mediated glucose transport	0.0	5.0	32.0	-0.058	0.051	1000.0	-1000.0	-0.066	-1000.0
PDGFR-alpha signaling pathway	0.0	39.0	44.0	-0.122	0.046	1000.0	-1000.0	-0.073	-1000.0
IFN-gamma pathway	0.0	64.0	68.0	-0.19	0.032	1000.0	-1000.0	-0.114	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	63.0	68.0	-0.058	0.041	1000.0	-1000.0	-0.084	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	13.0	37.0	-0.033	0.043	1000.0	-1000.0	-0.076	-1000.0
Signaling events mediated by HDAC Class III	0.0	20.0	40.0	-0.158	0.029	1000.0	-1000.0	-0.056	-1000.0
S1P5 pathway	0.0	4.0	17.0	-0.016	0.016	1000.0	-1000.0	-0.065	-1000.0
ceramide signaling pathway	0.0	22.0	49.0	-0.133	0.031	1000.0	-1000.0	-0.062	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	31.0	83.0	-0.058	0.079	1000.0	-1000.0	-0.095	-1000.0
Signaling events mediated by HDAC Class I	0.0	10.0	104.0	-0.086	0.069	1000.0	-1000.0	-0.093	-1000.0
FoxO family signaling	0.0	55.0	64.0	-0.244	0.073	1000.0	-1000.0	-0.077	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	9.0	15.0	-0.031	0.029	1000.0	-1000.0	-0.034	-1000.0
Retinoic acid receptors-mediated signaling	0.0	52.0	58.0	-0.093	0.035	1000.0	-1000.0	-0.091	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	10.0	36.0	-0.033	0.05	1000.0	-1000.0	-0.093	-1000.0
Atypical NF-kappaB pathway	0.0	6.0	31.0	-0.018	0.048	1000.0	-1000.0	-0.051	-1000.0
IL2 signaling events mediated by PI3K	0.0	33.0	58.0	-0.074	0.063	1000.0	-1000.0	-0.106	-1000.0
Regulation of p38-alpha and p38-beta	0.0	30.0	54.0	-0.11	0.046	1000.0	-1000.0	-0.08	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	63.0	76.0	-0.051	0.045	1000.0	-1000.0	-0.101	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	4.0	27.0	-0.022	0.041	1000.0	-1000.0	-0.072	-1000.0
IL2 signaling events mediated by STAT5	0.0	11.0	22.0	-0.073	0.039	1000.0	-1000.0	-0.059	-1000.0
Class I PI3K signaling events	0.0	43.0	73.0	-0.058	0.029	1000.0	-1000.0	-0.072	-1000.0
Arf6 trafficking events	0.0	28.0	71.0	-0.039	0.037	1000.0	-1000.0	-0.093	-1000.0
IGF1 pathway	0.0	42.0	57.0	-0.075	0.031	1000.0	-1000.0	-0.126	-1000.0
S1P3 pathway	0.0	26.0	42.0	-0.075	0.041	1000.0	-1000.0	-0.043	-1000.0
Angiopoietin receptor Tie2-mediated signaling	0.0	50.0	88.0	-0.183	0.08	1000.0	-1000.0	-0.144	-1000.0
Rapid glucocorticoid signaling	0.0	13.0	20.0	-0.035	0.016	1000.0	-1000.0	-0.053	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	0.0	102.0	120.0	-0.168	0.164	1000.0	-1000.0	-0.09	-1000.0
PDGFR-beta signaling pathway	0.0	32.0	97.0	-0.075	0.056	1000.0	-1000.0	-0.121	-1000.0
S1P4 pathway	0.0	7.0	25.0	-0.016	0.025	1000.0	-1000.0	-0.062	-1000.0
p38 MAPK signaling pathway	0.0	38.0	44.0	-0.124	0.02	1000.0	-1000.0	-0.092	-1000.0
Arf1 pathway	0.0	5.0	54.0	-0.03	0.034	1000.0	-1000.0	-0.066	-1000.0
Alternative NF-kappaB pathway	0.0	4.0	13.0	-0.012	0.016	1000.0	-1000.0	-0.085	-1000.0
Regulation of Androgen receptor activity	0.0	64.0	70.0	-0.261	0.061	1000.0	-1000.0	-0.091	-1000.0
Total	162	12916	7203	-24.3814090675	-993.56866729	131000	-131000	-11.2242446428	-131000