Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	8.0	419.0	51.0	-0.627	0.038	1000.0	-1000.0	-0.079	-1000.0
HIF-1-alpha transcription factor network	5.0	420.0	76.0	-0.456	0.052	1000.0	-1000.0	-0.05	-1000.0
Osteopontin-mediated events	4.0	174.0	38.0	-0.31	0.041	1000.0	-1000.0	-0.045	-1000.0
Signaling events mediated by the Hedgehog family	4.0	231.0	52.0	-0.277	0.115	1000.0	-1000.0	-0.029	-1000.0
TCGA08_p53	4.0	31.0	7.0	-0.086	0.053	1000.0	-1000.0	-0.007	-1000.0
TCGA08_retinoblastoma	4.0	38.0	8.0	-0.105	0.05	1000.0	-1000.0	-0.004	-1000.0
IL23-mediated signaling events	4.0	281.0	60.0	-0.56	0.036	1000.0	-1000.0	-0.076	-1000.0
IL4-mediated signaling events	3.0	344.0	91.0	-0.714	0.572	1000.0	-1000.0	-0.091	-1000.0
Fc-epsilon receptor I signaling in mast cells	3.0	344.0	97.0	-0.158	0.038	1000.0	-1000.0	-0.06	-1000.0
Endothelins	3.0	380.0	96.0	-0.263	0.049	1000.0	-1000.0	-0.049	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	382.0	125.0	-0.125	0.053	1000.0	-1000.0	-0.055	-1000.0
IL27-mediated signaling events	3.0	174.0	51.0	-0.213	0.152	1000.0	-1000.0	-0.066	-1000.0
Wnt signaling	3.0	23.0	7.0	-0.092	0.037	1000.0	-1000.0	-0.021	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	3.0	263.0	68.0	-0.467	0.166	1000.0	-1000.0	-0.076	-1000.0
EGFR-dependent Endothelin signaling events	3.0	78.0	21.0	-0.104	0.053	1000.0	-1000.0	-0.046	-1000.0
Caspase cascade in apoptosis	2.0	165.0	74.0	-0.062	0.052	1000.0	-1000.0	-0.035	-1000.0
IL12-mediated signaling events	2.0	216.0	87.0	-0.274	0.038	1000.0	-1000.0	-0.068	-1000.0
Syndecan-1-mediated signaling events	2.0	88.0	34.0	-0.164	0.038	1000.0	-1000.0	-0.037	-1000.0
Visual signal transduction: Cones	2.0	104.0	38.0	-0.157	0.044	1000.0	-1000.0	-0.009	-1000.0
Noncanonical Wnt signaling pathway	2.0	53.0	26.0	-0.092	0.037	1000.0	-1000.0	-0.044	-1000.0
Thromboxane A2 receptor signaling	2.0	216.0	105.0	-0.094	0.048	1000.0	-1000.0	-0.047	-1000.0
Arf6 signaling events	2.0	129.0	62.0	-0.104	0.038	1000.0	-1000.0	-0.028	-1000.0
BMP receptor signaling	2.0	192.0	81.0	-0.202	0.076	1000.0	-1000.0	-0.054	-1000.0
amb2 Integrin signaling	2.0	221.0	82.0	-0.15	0.049	1000.0	-1000.0	-0.039	-1000.0
Nectin adhesion pathway	2.0	155.0	63.0	-0.106	0.058	1000.0	-1000.0	-0.059	-1000.0
Glucocorticoid receptor regulatory network	2.0	254.0	114.0	-0.402	0.085	1000.0	-1000.0	-0.06	-1000.0
IL1-mediated signaling events	2.0	137.0	62.0	-0.142	0.064	1000.0	-1000.0	-0.042	-1000.0
Ephrin B reverse signaling	2.0	133.0	48.0	-0.119	0.038	1000.0	-1000.0	-0.039	-1000.0
Syndecan-3-mediated signaling events	2.0	85.0	35.0	-0.186	0.05	1000.0	-1000.0	-0.03	-1000.0
Signaling mediated by p38-alpha and p38-beta	2.0	130.0	44.0	-0.137	0.038	1000.0	-1000.0	-0.03	-1000.0
Integrins in angiogenesis	2.0	194.0	84.0	-0.158	0.045	1000.0	-1000.0	-0.053	-1000.0
TCR signaling in naïve CD8+ T cells	2.0	191.0	93.0	-0.053	0.053	1000.0	-1000.0	-0.052	-1000.0
Glypican 2 network	2.0	9.0	4.0	-0.025	0.0	1000.0	-1000.0	0.0	-1000.0
Calcium signaling in the CD4+ TCR pathway	2.0	74.0	31.0	-0.238	0.039	1000.0	-1000.0	-0.051	-1000.0
IL6-mediated signaling events	2.0	166.0	75.0	-0.448	0.045	1000.0	-1000.0	-0.045	-1000.0
BCR signaling pathway	2.0	255.0	99.0	-0.193	0.066	1000.0	-1000.0	-0.067	-1000.0
Syndecan-4-mediated signaling events	2.0	170.0	67.0	-0.111	0.041	1000.0	-1000.0	-0.043	-1000.0
Plasma membrane estrogen receptor signaling	2.0	248.0	86.0	-0.198	0.187	1000.0	-1000.0	-0.06	-1000.0
Visual signal transduction: Rods	2.0	149.0	52.0	-0.208	0.051	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	2.0	197.0	78.0	-0.114	0.044	1000.0	-1000.0	-0.049	-1000.0
Coregulation of Androgen receptor activity	1.0	94.0	76.0	-0.216	0.051	1000.0	-1000.0	-0.023	-1000.0
ErbB4 signaling events	1.0	69.0	69.0	-0.301	0.072	1000.0	-1000.0	-0.046	-1000.0
PLK2 and PLK4 events	1.0	3.0	3.0	-0.012	0.037	1000.0	-1000.0	-0.007	-1000.0
Syndecan-2-mediated signaling events	1.0	136.0	69.0	-0.186	0.063	1000.0	-1000.0	-0.064	-1000.0
Cellular roles of Anthrax toxin	1.0	46.0	39.0	-0.059	0.036	1000.0	-1000.0	-0.024	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	129.0	85.0	-0.109	0.046	1000.0	-1000.0	-0.05	-1000.0
Signaling events mediated by PTP1B	1.0	138.0	76.0	-0.141	0.091	1000.0	-1000.0	-0.035	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	67.0	65.0	-0.243	0.082	1000.0	-1000.0	-0.043	-1000.0
Presenilin action in Notch and Wnt signaling	1.0	77.0	61.0	-0.159	0.049	1000.0	-1000.0	-0.049	-1000.0
FOXA2 and FOXA3 transcription factor networks	1.0	58.0	46.0	-0.24	0.044	1000.0	-1000.0	-0.087	-1000.0
Glypican 1 network	1.0	52.0	48.0	-0.009	0.052	1000.0	-1000.0	-0.035	-1000.0
PLK1 signaling events	1.0	93.0	85.0	-0.137	0.055	1000.0	-1000.0	-0.032	-1000.0
mTOR signaling pathway	1.0	102.0	53.0	-0.064	0.038	1000.0	-1000.0	-0.044	-1000.0
IFN-gamma pathway	1.0	107.0	68.0	-0.106	0.04	1000.0	-1000.0	-0.056	-1000.0
Ceramide signaling pathway	1.0	84.0	76.0	-0.062	0.053	1000.0	-1000.0	-0.031	-1000.0
TRAIL signaling pathway	1.0	76.0	48.0	-0.029	0.038	1000.0	-1000.0	-0.038	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	63.0	52.0	-0.088	0.068	1000.0	-1000.0	-0.051	-1000.0
HIF-2-alpha transcription factor network	1.0	61.0	43.0	-0.158	0.084	1000.0	-1000.0	-0.048	-1000.0
S1P1 pathway	1.0	61.0	36.0	-0.135	0.037	1000.0	-1000.0	-0.042	-1000.0
FAS signaling pathway (CD95)	1.0	67.0	47.0	-0.103	0.048	1000.0	-1000.0	-0.044	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	46.0	45.0	-0.05	0.052	1000.0	-1000.0	-0.043	-1000.0
Canonical Wnt signaling pathway	1.0	78.0	51.0	-0.159	0.094	1000.0	-1000.0	-0.057	-1000.0
EPHB forward signaling	1.0	108.0	85.0	-0.069	0.077	1000.0	-1000.0	-0.072	-1000.0
Effects of Botulinum toxin	1.0	31.0	26.0	-0.028	0.034	1000.0	-1000.0	-0.009	-1000.0
Nongenotropic Androgen signaling	1.0	62.0	52.0	-0.029	0.047	1000.0	-1000.0	-0.032	-1000.0
LPA receptor mediated events	1.0	162.0	102.0	-0.221	0.063	1000.0	-1000.0	-0.082	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	1.0	132.0	74.0	-0.107	0.056	1000.0	-1000.0	-0.063	-1000.0
Regulation of Telomerase	1.0	102.0	102.0	-0.111	0.072	1000.0	-1000.0	-0.044	-1000.0
IGF1 pathway	1.0	59.0	57.0	-0.054	0.062	1000.0	-1000.0	-0.049	-1000.0
Insulin Pathway	1.0	138.0	74.0	-0.129	0.061	1000.0	-1000.0	-0.042	-1000.0
VEGFR1 specific signals	1.0	65.0	56.0	-0.027	0.038	1000.0	-1000.0	-0.052	-1000.0
Signaling events mediated by PRL	1.0	35.0	34.0	-0.106	0.055	1000.0	-1000.0	-0.043	-1000.0
E-cadherin signaling in keratinocytes	1.0	57.0	43.0	-0.082	0.038	1000.0	-1000.0	-0.036	-1000.0
E-cadherin signaling events	1.0	7.0	5.0	-0.008	0.036	1000.0	-1000.0	0.015	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	21.0	17.0	-0.0	0.042	1000.0	-1000.0	-0.028	-1000.0
Aurora B signaling	1.0	107.0	67.0	-0.124	0.045	1000.0	-1000.0	-0.038	-1000.0
LPA4-mediated signaling events	0.0	3.0	12.0	-0.005	0.046	1000.0	-1000.0	-0.024	-1000.0
ErbB2/ErbB3 signaling events	0.0	29.0	65.0	-0.021	0.077	1000.0	-1000.0	-0.069	-1000.0
Regulation of nuclear SMAD2/3 signaling	0.0	105.0	136.0	-0.155	0.152	1000.0	-1000.0	-0.035	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	6.0	23.0	-0.003	0.068	1000.0	-1000.0	-0.03	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	0.0	8.0	34.0	-0.043	0.084	1000.0	-1000.0	-0.039	-1000.0
Canonical NF-kappaB pathway	0.0	17.0	39.0	-0.016	0.081	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by HDAC Class II	0.0	42.0	75.0	-0.111	0.073	1000.0	-1000.0	-0.027	-1000.0
BARD1 signaling events	0.0	18.0	57.0	-0.074	0.077	1000.0	-1000.0	-0.044	-1000.0
Sphingosine 1-phosphate (S1P) pathway	0.0	17.0	28.0	-0.033	0.042	1000.0	-1000.0	-0.021	-1000.0
Circadian rhythm pathway	0.0	13.0	22.0	-0.093	0.078	1000.0	-1000.0	-0.039	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	0.0	24.0	54.0	-0.039	0.052	1000.0	-1000.0	-0.056	-1000.0
Ephrin A  reverse signaling	0.0	5.0	7.0	0.0	0.028	1000.0	-1000.0	-0.005	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	9.0	17.0	-0.004	0.083	1000.0	-1000.0	-0.039	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.036	0.055	1000.0	-1000.0	0.011	-1000.0
Aurora A signaling	0.0	31.0	60.0	-0.042	0.085	1000.0	-1000.0	-0.021	-1000.0
p75(NTR)-mediated signaling	0.0	94.0	125.0	-0.17	0.089	1000.0	-1000.0	-0.058	-1000.0
Arf6 downstream pathway	0.0	20.0	43.0	-0.048	0.052	1000.0	-1000.0	-0.034	-1000.0
Aurora C signaling	0.0	4.0	7.0	-0.026	0.041	1000.0	-1000.0	-0.02	-1000.0
EPO signaling pathway	0.0	27.0	55.0	0.0	0.077	1000.0	-1000.0	-0.05	-1000.0
Insulin-mediated glucose transport	0.0	4.0	32.0	-0.026	0.058	1000.0	-1000.0	-0.025	-1000.0
PDGFR-alpha signaling pathway	0.0	34.0	44.0	-0.066	0.062	1000.0	-1000.0	-0.041	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	59.0	68.0	-0.026	0.066	1000.0	-1000.0	-0.031	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	14.0	37.0	-0.005	0.089	1000.0	-1000.0	-0.044	-1000.0
Signaling events mediated by HDAC Class III	0.0	19.0	40.0	-0.087	0.07	1000.0	-1000.0	-0.019	-1000.0
Reelin signaling pathway	0.0	55.0	56.0	-0.037	0.06	1000.0	-1000.0	-0.04	-1000.0
Signaling events regulated by Ret tyrosine kinase	0.0	67.0	82.0	-0.044	0.053	1000.0	-1000.0	-0.07	-1000.0
S1P5 pathway	0.0	8.0	17.0	-0.021	0.038	1000.0	-1000.0	-0.012	-1000.0
ceramide signaling pathway	0.0	30.0	49.0	-0.062	0.044	1000.0	-1000.0	-0.033	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	20.0	83.0	-0.04	0.071	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by HDAC Class I	0.0	20.0	104.0	-0.055	0.08	1000.0	-1000.0	-0.032	-1000.0
FoxO family signaling	0.0	52.0	64.0	-0.25	0.054	1000.0	-1000.0	-0.047	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	12.0	15.0	-0.042	0.037	1000.0	-1000.0	-0.031	-1000.0
Retinoic acid receptors-mediated signaling	0.0	43.0	58.0	-0.015	0.076	1000.0	-1000.0	-0.046	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	12.0	36.0	-0.075	0.078	1000.0	-1000.0	-0.052	-1000.0
Atypical NF-kappaB pathway	0.0	6.0	31.0	0.0	0.055	1000.0	-1000.0	-0.032	-1000.0
IL2 signaling events mediated by PI3K	0.0	20.0	58.0	-0.03	0.074	1000.0	-1000.0	-0.048	-1000.0
Regulation of p38-alpha and p38-beta	0.0	27.0	54.0	-0.048	0.071	1000.0	-1000.0	-0.057	-1000.0
TCGA08_rtk_signaling	0.0	24.0	26.0	-0.082	0.054	1000.0	-1000.0	-0.003	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	70.0	76.0	-0.048	0.062	1000.0	-1000.0	-0.067	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.0	0.066	1000.0	-1000.0	-0.038	-1000.0
IL2 signaling events mediated by STAT5	0.0	10.0	22.0	-0.064	0.045	1000.0	-1000.0	-0.044	-1000.0
Class I PI3K signaling events	0.0	48.0	73.0	-0.04	0.038	1000.0	-1000.0	-0.053	-1000.0
Arf6 trafficking events	0.0	5.0	71.0	-0.052	0.067	1000.0	-1000.0	-0.037	-1000.0
S1P3 pathway	0.0	23.0	42.0	-0.033	0.042	1000.0	-1000.0	-0.036	-1000.0
Angiopoietin receptor Tie2-mediated signaling	0.0	42.0	88.0	-0.109	0.088	1000.0	-1000.0	-0.074	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	28.0	33.0	-0.138	0.1	1000.0	-1000.0	-0.041	-1000.0
Rapid glucocorticoid signaling	0.0	11.0	20.0	-0.0	0.034	1000.0	-1000.0	-0.006	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	0.0	85.0	120.0	-0.11	0.087	1000.0	-1000.0	-0.057	-1000.0
PDGFR-beta signaling pathway	0.0	31.0	97.0	-0.04	0.087	1000.0	-1000.0	-0.061	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.029	0.029	1000.0	-1000.0	-0.009	-1000.0
S1P4 pathway	0.0	11.0	25.0	-0.0	0.042	1000.0	-1000.0	-0.026	-1000.0
p38 MAPK signaling pathway	0.0	27.0	44.0	-0.074	0.062	1000.0	-1000.0	-0.018	-1000.0
Arf1 pathway	0.0	4.0	54.0	-0.0	0.043	1000.0	-1000.0	-0.023	-1000.0
Alternative NF-kappaB pathway	0.0	1.0	13.0	0.0	0.097	1000.0	-1000.0	0.0	-1000.0
Regulation of Androgen receptor activity	0.0	49.0	70.0	-0.217	0.049	1000.0	-1000.0	-0.055	-1000.0
Total	143	11752	7203	-15.3676778457	8.35377695891	131000	-131000	-5.33063755118	-131000