Clinical Features MRNA_CNMF MRNA_CHIERARCHICAL CN_CNMF METHLYATION_CNMF RPPA_CNMF RPPA_CHIERARCHICAL MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL MIRSEQ_MATURE_CNMF MIRSEQ_MATURE_CHIERARCHICAL nMutated (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q TP53 141 (79%) 37 0.04517 1 0.02614 1 9.9999e-05 0.0183 0.00141 0.251 1 1 0.6979 1 0.00124 0.222 0.04559 1 0.1359 1 0.32467 1 0.8227 1 0.39196 1 NFE2L2 27 (15%) 151 0.00019 0.0344 0.00017 0.0309 0.01753 1 0.03736 1 0.25522 1 0.73707 1 9.9999e-06 0.00186 9.9999e-06 0.00186 0.02893 1 2e-05 0.00368 0.591 1 0.11416 1 CDKN2A 26 (15%) 152 0.00144 0.255 0.0055599 0.967 0.01808 1 0.66782 1 0.34088 1 0.16914 1 0.38427 1 0.45063 1 0.78279 1 0.51995 1 1 1 0.97369 1 KEAP1 22 (12%) 156 0.00154 0.271 0.00049 0.0882 0.16505 1 0.075789 1 0.20268 1 0.14767 1 0.073319 1 0.0162 1 0.69844 1 0.24822 1 0.0052199 0.913 0.8512 1 PTEN 14 (8%) 164 0.38001 1 0.32445 1 0.46557 1 0.13311 1 0.72027 1 0.95993 1 0.6259 1 0.44594 1 0.5719 1 0.48815 1 0.35679 1 0.78947 1 PIK3CA 27 (15%) 151 0.68862 1 0.75367 1 0.45143 1 0.54664 1 1 1 0.66408 1 0.33079 1 0.39208 1 0.61308 1 0.59717 1 0.45469 1 0.9564 1 MLL2 35 (20%) 143 0.16971 1 0.46384 1 0.24633 1 0.31437 1 0.69556 1 0.36195 1 0.34883 1 0.30124 1 0.94795 1 1 1 0.61162 1 0.13925 1 RB1 12 (7%) 166 0.31463 1 0.64395 1 0.44995 1 0.10791 1 0.65534 1 0.48032 1 0.56927 1 0.42112 1 0.57423 1 0.53343 1 NA NA NA NA IBTK 5 (3%) 173 0.49061 1 0.84787 1 0.73999 1 NA NA NA NA NA NA 0.80744 1 0.43047 1 1 1 0.84704 1 NA NA NA NA CYP11B1 15 (8%) 163 0.65133 1 0.68065 1 1 1 0.12561 1 0.24262 1 0.095109 1 0.63715 1 0.36294 1 0.5851 1 0.8047 1 0.18701 1 0.52572 1 NOTCH1 14 (8%) 164 0.81489 1 0.60561 1 0.53503 1 0.03428 1 0.59132 1 0.62883 1 0.74431 1 0.3641 1 0.18295 1 0.17952 1 0.48501 1 0.03662 1 SLC28A1 9 (5%) 169 0.01346 1 0.04966 1 0.03595 1 0.1348 1 0.32075 1 0.52488 1 0.04462 1 0.0080699 1 0.12475 1 0.50499 1 0.5362 1 0.28307 1 ASB5 9 (5%) 169 0.49171 1 0.55205 1 0.27938 1 NA NA 0.47402 1 1 1 0.4762 1 0.49508 1 0.43843 1 0.35761 1 NA NA NA NA CPS1 25 (14%) 153 0.76505 1 0.23612 1 0.52057 1 0.89152 1 0.72982 1 0.49669 1 1 1 0.78259 1 0.072319 1 0.34479 1 1 1 0.42803 1 EP300 8 (4%) 170 0.14643 1 0.11893 1 0.38299 1 NA NA 0.35844 1 1 1 0.092529 1 0.41644 1 0.4404 1 0.31119 1 NA NA NA NA ARID1A 12 (7%) 166 0.31127 1 0.55011 1 0.80652 1 0.35289 1 0.49633 1 0.59893 1 0.1348 1 0.63534 1 0.17492 1 0.69232 1 NA NA NA NA FBXW7 10 (6%) 168 0.49296 1 0.82882 1 0.55142 1 NA NA 0.6192 1 0.78939 1 0.83531 1 0.63637 1 0.93516 1 0.36421 1 NA NA NA NA