rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(3) 134908 3 3 3 1 0 1 0 2 0 0 0.809 0.0397 1.000 2 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(9), CYP2C9(3) 536360 12 10 12 3 5 4 0 2 1 0 0.484 0.0981 1.000 3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25B(2), CDK7(1), CDKN1A(2), CHEK1(5), NEK1(3), WEE1(4) 1849805 17 17 17 1 7 5 1 3 1 0 0.101 0.232 1.000 4 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(13), PDXP(1), PSAT1(3) 1279971 17 16 17 2 6 5 0 5 1 0 0.134 0.273 1.000 5 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(2) 191569 2 2 2 0 0 1 0 0 1 0 0.503 0.354 1.000 6 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(4), PGLYRP2(2) 477868 6 5 6 0 1 4 1 0 0 0 0.150 0.366 1.000 7 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 11 CCNE1(3), CKS1B(1), CUL1(4), E2F1(2), RBX1(1), SKP2(2), TFDP1(3), UBE2M(1) 1813849 17 16 17 1 5 8 0 2 2 0 0.0500 0.460 1.000 8 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(5), SPCS1(1), SPCS3(2) 816418 10 9 10 2 2 2 2 0 4 0 0.402 0.484 1.000 9 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), HBXIP(1), HRAS(5), SHC1(2), SOS1(11) 2332935 20 19 19 1 3 9 2 4 2 0 0.0289 0.515 1.000 10 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(6), GOT2(3), TAT(1), TYR(10) 1245159 20 18 20 4 2 12 0 3 3 0 0.215 0.523 1.000 11 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1), IFNG(1), IL12A(1), IL12B(3) 791855 6 6 6 1 3 1 0 0 2 0 0.523 0.531 1.000 12 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 7 CCNE1(3), CUL1(4), E2F1(2), FBXW7(10), TFDP1(3) 1728213 22 22 20 4 6 8 3 1 4 0 0.256 0.571 1.000 13 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(2), SUCLA2(2) 557526 4 4 4 0 1 1 0 2 0 0 0.314 0.629 1.000 14 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 8 CCNA1(1), CCNE1(3), CUL1(4), E2F1(2), SKP2(2), TFDP1(3) 1801654 15 14 15 1 6 7 0 1 1 0 0.0613 0.667 1.000 15 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(3), PLCD1(1), PRKCA(5), TGM2(1) 1305943 10 10 10 1 2 3 1 3 1 0 0.236 0.677 1.000 16 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(1), FDPS(1), GGPS1(2), IDI1(1), IDI2(2), SQLE(3) 1145747 10 9 10 0 3 3 0 4 0 0 0.0725 0.685 1.000 17 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(2), ACADM(1), ACADS(2), ACAT1(2), ECHS1(1), HADHA(2) 1439001 10 10 10 1 0 4 1 3 2 0 0.267 0.711 1.000 18 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(1), TGDS(1), UGDH(2), UXS1(4) 1040874 8 7 8 1 4 1 0 2 1 0 0.348 0.716 1.000 19 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(18), AKT1(1), ATM(8), BAX(1), CDKN1A(2), CPB2(3), CSNK1A1(2), CSNK1D(2), FHL2(1), GADD45A(1), HIF1A(1), IGFBP3(2), MAPK8(3), MDM2(2), NFKBIB(1) 5295407 48 37 48 3 18 16 1 8 3 2 0.00197 0.720 1.000 20 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(3) 453710 3 3 3 1 0 2 1 0 0 0 0.744 0.730 1.000 21 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(1), FDPS(1), IDI1(1), SQLE(3) 859199 6 6 6 0 1 2 0 3 0 0 0.207 0.749 1.000 22 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(1), HLA-DRA(1), HLA-DRB1(2), IL3(1) 804618 5 5 5 0 2 1 0 0 2 0 0.263 0.757 1.000 23 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(1), TGDS(1), UGDH(2), UGP2(4), UXS1(4) 1319800 12 11 12 2 5 2 0 3 2 0 0.351 0.803 1.000 24 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 10 AKR1C4(1), AKR1D1(3), CYP11A1(2), CYP11B2(7), CYP17A1(2), CYP21A2(2), HSD11B1(3), HSD11B2(1), HSD3B1(6), HSD3B2(3) 2066360 30 27 30 6 9 11 0 9 1 0 0.119 0.814 1.000 25 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 10 AKR1C4(1), AKR1D1(3), CYP11A1(2), CYP11B2(7), CYP17A1(2), CYP21A2(2), HSD11B1(3), HSD11B2(1), HSD3B1(6), HSD3B2(3) 2066360 30 27 30 6 9 11 0 9 1 0 0.119 0.814 1.000 26 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT2(1), FUT3(3), FUT5(4), FUT6(2) 1347433 10 9 10 2 0 5 4 1 0 0 0.297 0.819 1.000 27 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1) 302729 1 1 1 0 0 0 0 1 0 0 0.787 0.822 1.000 28 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(1), CD80(3), HLA-DRA(1), HLA-DRB1(2), IL10(2), IL4(2) 1054491 11 10 11 3 4 1 1 3 2 0 0.512 0.843 1.000 29 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(1), MTMR2(2), MTMR6(5), NFS1(2), TPK1(5) 1697224 15 14 15 2 5 5 1 3 1 0 0.243 0.843 1.000 30 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(4), GLS2(1), GLUD1(4), GLUD2(9) 1203525 18 17 18 4 5 7 0 3 3 0 0.453 0.845 1.000 31 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(1), CD4(1), HLA-DRA(1), HLA-DRB1(2), IL1B(1), IL4(2), IL5RA(3), IL6(1) 1418962 12 11 12 2 2 6 0 1 3 0 0.271 0.847 1.000 32 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(2), CBS(4), MUT(4) 1293204 10 9 10 0 3 4 0 1 2 0 0.0668 0.872 1.000 33 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 12 CCNA1(1), CCNA2(1), CCND1(1), CCNE1(3), CCNE2(2), E2F1(2), PRB1(5) 2155261 15 14 15 1 6 7 1 0 1 0 0.0629 0.909 1.000 34 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 11 CREB1(1), FOS(2), JUN(3), MAPK1(1), MAPK14(1), MAPK8(3), PRKCA(5) 1707534 16 15 15 3 8 5 1 1 1 0 0.355 0.941 1.000 35 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 14 APAF1(4), ATM(8), BAX(1), CCND1(1), CCNE1(3), CDKN1A(2), E2F1(2), GADD45A(1), MDM2(2) 4132140 24 23 24 1 7 9 1 5 2 0 0.0159 0.942 1.000 36 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 5 ARG1(2), ASL(4), GLS(4), GLUD1(4) 1235288 14 13 14 4 2 5 1 4 2 0 0.636 0.948 1.000 37 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(1), HLA-DRA(1), HLA-DRB1(2) 632428 4 4 4 2 2 0 0 0 2 0 0.783 0.954 1.000 38 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT2(3), TAT(1) 695155 4 4 4 2 1 2 0 1 0 0 0.812 0.962 1.000 39 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(13), NRG2(2), NRG3(8), PRKCA(5), PSEN1(3) 2379756 31 30 31 6 7 12 3 4 5 0 0.251 0.965 1.000 40 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(2), EPHX2(3), RDH11(1), RDH12(2), RDH13(1) 1272837 9 8 9 2 2 3 0 3 1 0 0.403 0.976 1.000 41 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1), TPI1(3) 431229 4 4 4 2 2 1 0 1 0 0 0.841 0.978 1.000 42 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(8), GOT2(3), LDHB(3), LDHC(3) 1794526 17 16 17 4 3 4 1 7 2 0 0.453 0.979 1.000 43 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 5 NFYA(1), NFYB(1), SP1(2), SP3(1) 1297398 5 5 5 1 0 3 0 1 1 0 0.622 0.979 1.000 44 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(2), CFL1(2), CFLAR(2) 1021642 6 6 6 2 1 2 0 1 2 0 0.725 0.980 1.000 45 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(2), ACO2(3), AFMID(1), GRHPR(2), HAO1(7), MDH1(1), MDH2(1), MTHFD1(4), MTHFD1L(2), MTHFD2(4) 3548938 27 25 27 4 10 8 1 4 4 0 0.0735 0.982 1.000 46 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), GSTZ1(2), HGD(4) 595240 7 7 7 4 2 3 0 1 1 0 0.889 0.983 1.000 47 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(2), ACOX3(5), FADS2(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5) 2697863 30 27 30 6 8 11 6 0 5 0 0.160 0.984 1.000 48 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(2), ACO2(3), GRHPR(2), HAO1(7), MDH1(1), MDH2(1), MTHFD1(4), MTHFD1L(2), MTHFD2(4) 3388767 26 24 26 4 10 8 1 4 3 0 0.0893 0.985 1.000 49 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(1), GRIA2(7), JUND(2), PPP1R1B(1) 995583 11 9 11 7 1 5 1 1 3 0 0.926 0.985 1.000 50 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(2), CLOCK(5), CRY1(3), CRY2(2), PER1(6) 2232341 18 16 18 3 5 6 3 3 1 0 0.253 0.986 1.000 51 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(2), CSF1(2), IL6(1), LDLR(4), LPL(3) 1412543 12 12 12 3 5 6 0 1 0 0 0.422 0.989 1.000 52 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(8), ATR(13), CDC25C(1), CHEK1(5), CHEK2(3) 4042217 30 23 30 3 9 10 3 5 3 0 0.0978 0.992 1.000 53 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(3), CHAT(9), CHKA(4), PDHA1(3), PDHA2(8), SLC18A3(8) 1839111 35 30 35 9 7 14 4 9 1 0 0.272 0.992 1.000 54 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 20 ASNS(5), CA12(2), CA14(1), CA3(4), CA4(1), CA5A(2), CA5B(2), CA6(2), CA7(3), CA9(1), GLS(4), GLS2(1), GLUD1(4), GLUL(4), HAL(2) 4202222 38 35 38 5 11 14 2 8 3 0 0.0381 0.992 1.000 55 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(3), NDUFB5(2), NDUFB6(1), NDUFB7(2), NDUFS1(4), NDUFV1(2), NDUFV2(2) 1837039 16 15 16 4 3 4 4 3 2 0 0.553 0.993 1.000 56 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(7), CKM(2), FBL(2), GPT(1), LDHB(3), LDHC(3), MAPK14(1), NCL(1) 2350356 20 18 20 4 6 8 1 3 2 0 0.261 0.994 1.000 57 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(2), DHRS2(2), DHRSX(4), PON1(7), PON2(1), PON3(1), RDH11(1), RDH12(2), RDH13(1) 2386466 21 17 21 4 6 5 1 7 2 0 0.192 0.995 1.000 58 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMPR1A(3), BMPR1B(1), BMPR2(1) 1652105 5 5 5 1 0 2 1 2 0 0 0.581 0.996 1.000 59 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(8), CDC25B(2), CDC25C(1), CHEK1(5), MYT1(4), WEE1(4) 3662407 24 22 24 3 8 9 2 3 2 0 0.147 0.996 1.000 60 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 13 ARF1(1), CCND1(1), CDKN1A(2), CFL1(2), E2F1(2), MDM2(2), NXT1(1), PRB1(5) 1790888 16 14 16 4 4 9 0 3 0 0 0.363 0.997 1.000 61 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 7 GABRA1(7), GABRA3(4), GABRA4(5), GABRA5(6), PRKCE(3) 1597644 25 22 25 7 1 12 4 5 3 0 0.548 0.997 1.000 62 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(1), LDLR(4), NR0B2(1), NR1H3(2), NR1H4(8), RXRA(2) 1443617 18 18 18 5 6 4 1 4 3 0 0.516 0.997 1.000 63 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 DLL1(1), FURIN(1), NOTCH1(18), PSEN1(3) 2426479 23 19 23 9 1 9 1 4 8 0 0.719 0.998 1.000 64 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 19 CSNK2A1(2), FOS(2), HRAS(5), IGF1(3), IGF1R(1), IRS1(7), JUN(3), MAP2K1(2), MAPK3(1), MAPK8(3), PIK3R1(2), PTPN11(3), RAF1(1), RASA1(8), SHC1(2), SOS1(11), SRF(2) 5966900 58 47 56 7 18 22 2 6 10 0 0.00740 0.998 1.000 65 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(1), CD3D(1), CD4(1) 856259 3 3 3 3 0 1 0 1 1 0 0.965 0.998 1.000 66 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(4), GSS(2), NFKB1(2), NOX1(2), RELA(3), TNF(1), XDH(11) 2642844 25 19 25 5 5 11 2 4 3 0 0.177 0.999 1.000 67 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 10 ATM(8), CDC25B(2), CDC25C(1), CHEK1(5), MYT1(4), WEE1(4) 3992171 24 22 24 3 8 9 2 3 2 0 0.136 0.999 1.000 68 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(2), F13B(13), HSD17B1(1), HSD17B4(1), HSD17B7(1), HSD3B1(6), HSD3B2(3) 2147171 27 24 27 7 10 8 1 7 1 0 0.393 0.999 1.000 69 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT2(1), FUT9(5), GBGT1(2), GLA(2), HEXA(5), NAGA(1), ST3GAL1(4), ST3GAL4(2), ST8SIA1(3) 2683176 25 21 25 5 7 9 1 7 1 0 0.174 0.999 1.000 70 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(2), FOSL1(1), FOSL2(1), IFNAR1(2), IFNB1(2), MAPK8(3), NFKB1(2), RELA(3), TNFRSF11A(2), TNFSF11(1), TRAF6(5) 2940852 24 20 24 4 10 10 1 1 2 0 0.208 0.999 1.000 71 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 23 ASNS(5), CA12(2), CA13(1), CA14(1), CA3(4), CA4(1), CA5A(2), CA5B(2), CA6(2), CA7(3), CA9(1), GLS(4), GLS2(1), GLUD1(4), GLUD2(9), GLUL(4), HAL(2) 4797582 48 42 48 8 14 19 2 8 5 0 0.0595 0.999 1.000 72 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), AASDHPPT(1), AASS(11), KARS(3) 1250104 16 13 16 5 2 9 1 2 2 0 0.709 0.999 1.000 73 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(3), EGF(6), EGFR(7), HGS(3), TF(6), TFRC(2) 3406063 27 24 26 4 10 10 0 5 2 0 0.143 0.999 1.000 74 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 20 CCNA1(1), CCNB1(2), CCND1(1), CCND2(3), CCND3(1), CCNE1(3), CDK7(1), CDKN1A(2), CDKN2B(1), CDKN2C(1), E2F1(2), RBL1(5), TFDP1(3) 3628886 26 23 26 4 8 8 3 4 3 0 0.170 0.999 1.000 75 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(2), CD3D(1), GZMB(1), HLA-A(6), ICAM1(2), ITGAL(1), ITGB2(5), PRF1(1) 2307379 19 18 19 9 4 5 0 4 5 1 0.731 0.999 1.000 76 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 9 GPR37(3), SNCAIP(3), UBE2E2(2), UBE2G1(1), UBE2G2(1), UBE2L6(1) 1445407 11 10 11 4 3 1 2 2 3 0 0.772 0.999 1.000 77 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(18), ABCB11(6), ABCB4(8), ABCC1(5), ABCC3(2), GSTP1(1) 3806542 40 28 40 9 14 15 4 5 1 1 0.107 0.999 1.000 78 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(3), ADORA2A(5), ADORA3(1), P2RY1(2), P2RY2(3), P2RY6(2) 1574980 16 13 16 5 4 8 1 2 1 0 0.245 0.999 1.000 79 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(2), CYP11A1(2), CYP11B2(7), CYP17A1(2), HSD11B1(3), HSD11B2(1), HSD3B1(6), HSD3B2(3) 1839040 26 23 26 8 6 11 0 8 1 0 0.362 0.999 1.000 80 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 ECHS1(1), EHHADH(1), HADHA(2), SDS(2) 1289139 6 6 6 7 1 1 1 1 2 0 0.995 0.999 1.000 81 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(1), CHPT1(1), LCMT1(2), LCMT2(1), METTL2B(1), METTL6(2), PCYT1B(2), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), WBSCR22(3) 3725202 31 27 31 5 7 13 2 3 6 0 0.0839 0.999 1.000 82 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1), DCN(1), FMOD(2), LUM(2) 963183 6 6 5 3 3 3 0 0 0 0 0.725 1.000 1.000 83 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2) 2110033 12 11 12 3 3 8 0 0 1 0 0.370 1.000 1.000 84 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2) 2110033 12 11 12 3 3 8 0 0 1 0 0.370 1.000 1.000 85 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(1), FOS(2), FYN(5), JUN(3), MAPK14(1), THBS1(1) 1948766 13 11 12 3 6 2 1 4 0 0 0.489 1.000 1.000 86 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH7(1), ADHFE1(2) 1495071 9 9 9 3 2 6 0 1 0 0 0.684 1.000 1.000 87 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(1), DHRS2(2), DHRSX(4), LCMT1(2), LCMT2(1), METTL2B(1), METTL6(2), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), WBSCR22(3) 3971100 34 29 34 6 10 13 2 3 6 0 0.0759 1.000 1.000 88 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 FUT2(1), FUT9(5), GCNT2(2), ST8SIA1(3) 1627540 11 11 11 4 3 3 0 4 1 0 0.707 1.000 1.000 89 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(3), ARG1(2), GLS(4), GLUD1(4), OAT(1), PRODH(1) 1468000 15 14 15 6 2 6 0 5 2 0 0.833 1.000 1.000 90 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A2(4), BCMO1(2), RDH5(1) 1031666 7 7 7 4 2 4 0 0 1 0 0.865 1.000 1.000 91 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 8 JAK1(2), JAK2(4), JAK3(7), PIAS1(5), PIAS3(3), PTPRU(7), SOAT1(1) 3563796 29 23 29 5 10 6 1 9 3 0 0.137 1.000 1.000 92 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 20 AKT1(1), CCND1(1), CCNE1(3), CDKN1A(2), E2F1(2), HRAS(5), MAPK1(1), MAPK3(1), NFKB1(2), PAK1(2), PIK3R1(2), RAC1(1), RAF1(1), RELA(3), TFDP1(3) 4313800 30 27 29 5 9 10 2 7 2 0 0.108 1.000 1.000 93 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(1), IFNGR1(4), IFNGR2(1), JAK1(2), JAK2(4), STAT1(2) 2175126 14 13 14 4 7 1 2 2 2 0 0.659 1.000 1.000 94 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 14 AKT1(1), HRAS(5), IGF1R(1), IRS1(7), MAP2K1(2), MAPK1(1), MAPK3(1), PIK3R1(2), RAF1(1), SHC1(2), SOS1(11) 4443098 34 31 33 5 7 16 2 6 3 0 0.0596 1.000 1.000 95 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(6), AASDHPPT(1), AASS(11), KARS(3) 1845412 22 18 22 7 3 9 2 5 3 0 0.749 1.000 1.000 96 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2A(2), POLR2B(6), POLR2D(1), POLR2E(2), POLRMT(2) 3554341 15 14 15 2 4 5 0 2 4 0 0.152 1.000 1.000 97 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(2), ACP2(1), ACPT(2), ENPP1(8), ENPP3(6), FLAD1(2), TYR(10) 2541512 31 25 31 9 4 17 3 1 6 0 0.510 1.000 1.000 98 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 8 ADAR(4), APOBEC2(2), APOBEC3F(1), APOBEC4(3) 1821832 10 9 10 3 0 5 0 3 2 0 0.631 1.000 1.000 99 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), ECHS1(1), HADH(1), HADHA(2), HADHB(3), HSD17B4(1), PPT1(1), PPT2(1) 2245979 11 11 11 3 4 3 0 2 2 0 0.552 1.000 1.000 100 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(3), GPD2(2), SDHA(2), SDHB(2) 1754928 9 8 9 3 4 2 0 2 1 0 0.703 1.000 1.000 101 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(2), ACO2(3), FH(2), IDH1(2), MDH1(1), MDH2(1), SDHB(2), SUCLA2(2) 2360197 15 14 15 4 5 6 1 1 2 0 0.495 1.000 1.000 102 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 CPOX(2), FECH(2), PPOX(1), UROD(1), UROS(1) 2007489 7 7 7 2 3 3 0 0 1 0 0.566 1.000 1.000 103 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(1), CD34(2), CD3D(1), CD4(1), CD58(1), CD8A(2), IL3(1), IL6(1) 1650191 10 9 10 6 1 4 0 3 2 0 0.924 1.000 1.000 104 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(3), CASP8(2), FADD(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1) 2226973 12 10 12 6 4 3 1 0 4 0 0.859 1.000 1.000 105 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(8), CARS2(1), GOT2(3), LDHAL6A(2), LDHAL6B(1), LDHB(3), LDHC(3), SDS(2), SULT1B1(4), SULT1C2(4), SULT1C4(1) 3303954 32 25 32 7 11 5 4 9 3 0 0.309 1.000 1.000 106 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 CPO(1), FECH(2), GATA1(3), HBB(2), UROD(1), UROS(1) 2078525 10 10 10 3 2 5 0 1 2 0 0.542 1.000 1.000 107 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(19), GNA12(2), PRKACB(3), PRKACG(1), PRKAR2B(3) 2666246 28 25 28 6 8 13 0 6 1 0 0.280 1.000 1.000 108 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(2), GAD1(5), HDC(6), PNMT(2), TH(2), TPH1(2) 1589560 19 18 19 6 6 10 1 1 1 0 0.402 1.000 1.000 109 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(5), MMP14(2), MMP2(3), MMP9(5), RECK(3), TIMP2(1), TIMP4(1) 1987015 20 17 19 5 2 13 2 2 1 0 0.353 1.000 1.000 110 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(1), CD8A(2), CSF1(2), IL3(1), IL4(2), IL6(1), IL7(1) 1620210 10 9 10 7 0 6 0 2 2 0 0.931 1.000 1.000 111 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(3), PLCG1(3), PRKCA(5) 1778924 11 11 11 4 3 4 2 1 1 0 0.706 1.000 1.000 112 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 FUT2(1), FUT9(5), GBGT1(2), GLA(2), HEXA(5), NAGA(1), ST3GAL1(4), ST8SIA1(3) 2848570 23 20 23 5 6 9 1 6 1 0 0.213 1.000 1.000 113 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(2), GPI(5), HK1(2), PFKL(2), PGK1(2), PKLR(4), TPI1(3) 2444355 20 16 20 6 5 8 0 3 4 0 0.344 1.000 1.000 114 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA4(1), PSMA5(1), PSMB3(1), PSMB4(2), PSMC3(2), PSMD14(3), RPN1(1), UBE2A(2), UBE3A(6) 3424451 19 19 19 4 6 10 0 1 2 0 0.340 1.000 1.000 115 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO2(1), ENO3(1), FARS2(2), GOT2(3), PAH(3), TAT(1), YARS(1) 2200189 12 11 12 4 3 5 0 3 1 0 0.581 1.000 1.000 116 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(2), IFNG(1), IL10(2), IL12A(1), IL12B(3), IL16(5), IL1A(1), IL3(1), IL4(2), IL6(1), LTA(2), TNF(1) 2630179 23 21 23 6 7 8 1 6 1 0 0.409 1.000 1.000 117 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(2), JAK2(4), JAK3(7), MAPK1(1), MAPK3(1), STAT3(2), TYK2(8) 3098001 25 22 25 6 6 8 1 6 4 0 0.291 1.000 1.000 118 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(2), ECHS1(1), EHHADH(1), GCDH(2), HADHA(2), SDHB(2), SDS(2) 2074543 12 11 12 9 3 2 2 2 3 0 0.988 1.000 1.000 119 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(2), CSAD(2), GAD1(5), GAD2(6), GGT1(1) 1529828 16 13 16 9 7 6 0 2 1 0 0.895 1.000 1.000 120 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(5), HK1(2), HK2(5), HK3(5), IMPA1(2), PGM1(1), TGDS(1) 2708377 21 19 21 5 7 9 0 3 2 0 0.269 1.000 1.000 121 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), MIOX(1), UGDH(2) 2252196 12 12 12 4 5 6 0 0 1 0 0.528 1.000 1.000 122 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(1), CAPN1(2), CAPNS2(1), CDK5(1), CDK5R1(1), CSNK1A1(2), CSNK1D(2), MAPT(4) 2464708 14 14 14 4 5 5 0 0 4 0 0.581 1.000 1.000 123 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(4), ST3GAL4(2), ST3GAL5(2), ST6GALNAC4(1), ST8SIA1(3) 1496006 13 12 13 6 5 5 1 1 1 0 0.728 1.000 1.000 124 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(2), IL1B(1), MST1(1), MST1R(3), TNF(1) 1722648 8 8 8 3 3 4 0 1 0 0 0.629 1.000 1.000 125 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 8 CAMK1G(3), MEF2A(2), MEF2C(4), MEF2D(3), MYOD1(1) 1549400 13 13 13 9 5 5 1 1 1 0 0.970 1.000 1.000 126 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(5), ICAM1(2), ITGA4(4), ITGAL(1), ITGB1(5), ITGB2(5), SELE(4), SELL(2) 3220732 28 21 28 6 6 10 1 9 2 0 0.265 1.000 1.000 127 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 10 IL6(1), IL6R(1), JAK1(2), JAK2(4), JAK3(7), PIAS3(3), PTPRU(7), STAT3(2) 3951847 27 23 27 5 9 7 1 6 4 0 0.140 1.000 1.000 128 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(1), PAPSS2(1), SULT1A2(2), SULT1E1(1), SULT2A1(3) 1619951 8 8 8 4 2 3 0 2 1 0 0.882 1.000 1.000 129 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(7), G6PD(1), GCLC(2), GCLM(1), GGT1(1), GPX5(2), GPX6(2), GSR(4), GSS(2), GSTA1(3), GSTA2(2), GSTA4(1), GSTA5(2), GSTM3(1), GSTM4(3), GSTM5(3), GSTP1(1), GSTZ1(2), IDH1(2), MGST1(2), OPLAH(5) 5769397 49 46 49 9 11 26 0 10 2 0 0.0295 1.000 1.000 130 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(1), CYP2A13(1), CYP2A6(5), CYP2A7(1), NAT2(2), XDH(11) 2120048 21 19 21 7 4 10 1 3 3 0 0.447 1.000 1.000 131 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(4), MBTPS1(3), MBTPS2(3), SCAP(4), SREBF1(2), SREBF2(3) 3140491 20 19 20 5 9 5 1 4 1 0 0.328 1.000 1.000 132 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(7), G6PD(1), GCLC(2), GCLM(1), GGT1(1), GPX5(2), GSS(2), GSTA1(3), GSTA2(2), GSTA4(1), GSTM3(1), GSTM4(3), GSTM5(3), GSTP1(1), GSTZ1(2), IDH1(2), MGST1(2), PGD(1) 4764221 37 35 37 7 8 21 1 6 1 0 0.0594 1.000 1.000 133 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(2), IL13RA2(1), IL4R(2), JAK1(2), JAK2(4), TYK2(8) 2764965 19 18 19 6 6 5 3 1 4 0 0.626 1.000 1.000 134 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(2), IL13RA2(1), IL4R(2), JAK1(2), JAK2(4), TYK2(8) 2764965 19 18 19 6 6 5 3 1 4 0 0.626 1.000 1.000 135 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 8 IFNG(1), IFNGR1(4), JAK1(2), JAK2(4), PLA2G2A(1), PTPRU(7), STAT1(2) 2943794 21 20 21 5 11 1 2 4 3 0 0.429 1.000 1.000 136 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 19 ACY1(2), ALDH18A1(3), ARG1(2), ASL(4), CKM(2), CKMT2(3), GATM(1), GLUD1(4), NAGS(1), OAT(1), ODC1(1), OTC(3), PYCR1(1), SMS(2) 3794532 30 27 30 7 8 7 3 5 7 0 0.304 1.000 1.000 137 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(2), EIF2S2(1), MAP3K14(1), NFKB1(2), RELA(3) 2392863 9 7 9 3 2 1 1 2 3 0 0.722 1.000 1.000 138 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(14), RANGAP1(4) 2241521 18 16 18 5 4 5 2 4 3 0 0.822 1.000 1.000 139 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 14 AKT1(1), AKT3(3), BPNT1(1), ILK(2), MAPK1(1), MAPK3(1), PDK1(1), PIK3CD(4), RBL2(8), SHC1(2), SOS1(11) 4604056 35 30 35 7 9 11 1 10 4 0 0.222 1.000 1.000 140 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 20 CSNK2A1(2), FOS(2), HRAS(5), INSR(10), IRS1(7), JUN(3), MAP2K1(2), MAPK3(1), MAPK8(3), PIK3R1(2), PTPN11(3), RAF1(1), RASA1(8), SHC1(2), SLC2A4(2), SOS1(11), SRF(2) 6147331 66 50 64 10 19 24 2 9 12 0 0.0142 1.000 1.000 141 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(10), GNAS(6), GNB1(1), PRKAR1A(2) 1729256 19 18 19 8 6 5 2 5 1 0 0.855 1.000 1.000 142 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 16 CD3D(1), CD80(3), CD86(3), CTLA4(1), HLA-DRA(1), HLA-DRB1(2), ICOS(2), ITK(2), LCK(3), PIK3R1(2), PTPN11(3) 2806587 23 22 23 7 9 3 2 5 4 0 0.628 1.000 1.000 143 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), CD4(1), FYN(5), HLA-DRA(1), HLA-DRB1(2), LCK(3), PTPRC(7), ZAP70(5) 2400965 25 20 25 7 8 5 3 7 2 0 0.557 1.000 1.000 144 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(2), PLCB1(8), PRKCA(5), RELA(3) 2182673 18 15 18 8 5 6 2 3 2 0 0.887 1.000 1.000 145 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 DAG1(2), ITPKA(1), ITPKB(6) 1596363 9 9 9 5 3 3 1 1 1 0 0.853 1.000 1.000 146 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(5), HK1(2), HK2(5), HK3(5), IMPA1(2), PGM1(1), TGDS(1) 3086344 21 19 21 5 7 9 0 3 2 0 0.249 1.000 1.000 147 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(6), GNB1(1), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCA(5) 2524765 25 24 25 9 9 7 1 5 3 0 0.829 1.000 1.000 148 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(1), ACAA2(1), ACAT1(2), ECHS1(1), EHHADH(1), HADHA(2), HADHB(3), SDS(2) 2220067 13 13 13 7 3 4 1 3 2 0 0.933 1.000 1.000 149 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(1), ALPL(3), ALPP(3), ALPPL2(1), FPGS(2), GCH1(2), GGH(2) 1710521 14 12 14 9 5 6 0 2 1 0 0.906 1.000 1.000 150 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(5), ICAM1(2), ITGAL(1), ITGAM(7), ITGB2(5), SELE(4), SELL(2) 2773710 26 23 26 7 7 8 2 7 2 0 0.363 1.000 1.000 151 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 7 IFNAR1(2), IFNB1(2), JAK1(2), PTPRU(7), STAT1(2), STAT2(1), TYK2(8) 3212087 24 23 24 6 9 8 1 2 4 0 0.301 1.000 1.000 152 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(3), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3) 3994474 24 23 24 8 6 4 2 5 7 0 0.659 1.000 1.000 153 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(3), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3) 3994474 24 23 24 8 6 4 2 5 7 0 0.659 1.000 1.000 154 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(3), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3) 3994474 24 23 24 8 6 4 2 5 7 0 0.659 1.000 1.000 155 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 11 AKT1(1), HRAS(5), KLK2(2), NTRK1(4), PIK3R1(2), PLCG1(3), PRKCA(5), SHC1(2), SOS1(11) 3550747 35 31 34 9 10 13 3 4 5 0 0.404 1.000 1.000 156 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(2), SEC61A2(1), SRP54(1), SRP72(2), SRPR(2) 1995421 8 8 8 3 2 3 2 1 0 0 0.810 1.000 1.000 157 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 AKT1(1), GH1(2), GHR(3), HRAS(5), IGF1(3), IGF1R(1), PIK3R1(2), SHC1(2), SOD2(1) 2935762 20 18 19 5 6 11 2 1 0 0 0.344 1.000 1.000 158 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(1), CSF1(2), HLA-DRA(1), HLA-DRB1(2), IFNA1(1), IFNB1(2), IFNG(1), IL10(2), IL12A(1), IL12B(3), IL1A(1), IL3(1), IL4(2), IL6(1), IL7(1), LTA(2), TGFB1(1), TGFB2(3), TNF(1) 3532592 29 26 29 8 9 9 1 6 4 0 0.363 1.000 1.000 159 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(2), CDC25B(2), CDC25C(1), PRKCA(5) 2442594 10 10 10 4 3 2 2 1 2 0 0.829 1.000 1.000 160 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 UBE2A(2), UBE2C(1), UBE2D1(1), UBE2D2(2), UBE2E3(2), UBE2G1(1), UBE2G2(1), UBE2J1(2), UBE2L6(1), UBE2M(1), UBE3A(6) 2775361 20 19 20 6 5 9 0 3 3 0 0.639 1.000 1.000 161 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(2), GCK(5), GFPT1(1), GNE(2), GNPDA2(4), HEXA(5), HK1(2), HK2(5), HK3(5), RENBP(2), UAP1(2) 4479741 35 28 35 8 9 15 0 5 6 0 0.228 1.000 1.000 162 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(5), FOS(2), HRAS(5), IL3(1), JAK2(4), MAP2K1(2), MAPK3(1), RAF1(1), SHC1(2), SOS1(11), STAT5A(2) 4680668 36 33 35 8 7 15 3 7 4 0 0.228 1.000 1.000 163 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(3), ARPC1A(4), CDC42(1), RAC1(1), WASF1(1), WASL(2) 2152294 12 12 11 9 5 5 0 1 1 0 0.992 1.000 1.000 164 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(6), EGFR(7), ERBB3(4), NRG1(3), UBE2D1(1) 2703897 21 19 20 6 5 7 0 6 3 0 0.538 1.000 1.000 165 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V0A1(3), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), FDXR(3) 4248967 27 25 27 8 7 6 2 5 7 0 0.517 1.000 1.000 166 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(2), CPT1A(5), LEPR(15), PRKAA2(5), PRKAB2(1), PRKAG2(4) 3837576 32 28 32 7 6 10 4 7 5 0 0.346 1.000 1.000 167 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(1), GUSB(2), UCHL3(1), UGDH(2), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(3), UGT1A9(3), UGT2B15(3), UGT2B4(8) 4657758 34 29 34 8 4 15 4 10 1 0 0.335 1.000 1.000 168 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3D(1), IFNG(1), IL4(2), TGFB1(1), TGFB2(3), TGFBR2(3), TGFBR3(8) 2812125 19 17 19 9 7 5 0 4 3 0 0.875 1.000 1.000 169 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(1), ADSS(1), HPRT1(1), IMPDH1(2), MTHFD2(4), POLB(1), POLD1(2), POLG(2), PRPS2(1), RRM1(1) 3304059 16 14 16 4 4 5 0 6 1 0 0.426 1.000 1.000 170 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(2), CDC25B(2), CDC25C(1), CDK7(1), SHH(2), XPO1(2) 2295546 10 10 10 4 2 2 1 4 1 0 0.861 1.000 1.000 171 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(2), FARSA(5), GOT2(3), PAH(3), TAT(1), YARS(1), YARS2(2) 2309679 17 15 17 6 4 9 0 3 1 0 0.616 1.000 1.000 172 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(2), IFNB1(2), JAK1(2), STAT1(2), STAT2(1), TYK2(8) 2863741 18 18 18 6 6 7 1 1 3 0 0.608 1.000 1.000 173 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA4(1), PSMA5(1), PSMB3(1), PSMB4(2), PSMB8(2) 2307764 7 7 7 3 4 2 0 0 1 0 0.802 1.000 1.000 174 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(3), F13A1(6), F2R(2), FGA(5), FGB(4), FGG(2), PLAT(1), PLAU(2), PLG(2), SERPINB2(4) 3549422 31 25 31 8 6 11 4 6 3 1 0.471 1.000 1.000 175 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(13), CD38(2), ENPP1(8), ENPP3(6), NADSYN1(7), NMNAT2(2), NNT(10), NT5E(2) 3850423 50 39 50 11 13 19 2 10 6 0 0.185 1.000 1.000 176 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 17 CSNK2A1(2), FOS(2), HRAS(5), JUN(3), KLK2(2), MAP2K1(2), MAPK3(1), MAPK8(3), NGFR(1), PIK3R1(2), PLCG1(3), RAF1(1), SHC1(2), SOS1(11) 4477637 40 34 38 9 16 15 2 5 2 0 0.230 1.000 1.000 177 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 29 AKR1C4(1), AKR1D1(3), ARSB(2), ARSD(1), ARSE(2), CYP11B2(7), HSD11B1(3), HSD11B2(1), HSD3B1(6), HSD3B2(3), SRD5A1(2), SRD5A2(2), STS(6), SULT1E1(1), SULT2A1(3), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(3), UGT1A9(3), UGT2B15(3), UGT2B4(8) 6967739 71 52 71 14 15 26 4 20 6 0 0.0507 1.000 1.000 178 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BRAF(8), CREB1(1), CREB3(2), CREB5(3), MAPK1(1), RAF1(1), SNX13(5) 2985230 21 19 21 7 8 6 1 3 3 0 0.719 1.000 1.000 179 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(2), EPOR(2), FOS(2), HRAS(5), JAK2(4), JUN(3), MAP2K1(2), MAPK3(1), MAPK8(3), PLCG1(3), RAF1(1), SHC1(2), SOS1(11), STAT5A(2) 5686152 43 35 41 9 14 15 3 7 4 0 0.163 1.000 1.000 180 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 14 AKT1(1), BCAR1(6), ILK(2), ITGB1(5), MAPK1(1), MAPK3(1), PDK2(2), PDPK1(1), PIK3R1(2), PTK2(6), SHC1(2), SOS1(11) 4306258 40 34 40 9 10 14 2 11 3 0 0.294 1.000 1.000 181 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP7(2), DFFB(2), GZMB(1), HMGB2(1), TOP2A(2), TOP2B(4) 2467278 12 11 12 6 3 4 2 2 1 0 0.954 1.000 1.000 182 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(1), CBS(4), GGT1(1), MARS(1), MAT1A(1), PAPSS2(1), SCLY(1), SEPHS1(3) 3276787 13 11 13 7 4 5 0 0 4 0 0.873 1.000 1.000 183 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(3), LARS(1), LARS2(3), PDHA1(3), PDHA2(8) 2655435 19 17 19 6 4 7 2 5 1 0 0.703 1.000 1.000 184 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(3), FH(2), MDH1(1), OGDH(3), SDHA(2), SUCLA2(2) 2485493 13 13 13 7 2 6 1 3 1 0 0.908 1.000 1.000 185 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), ECHS1(1), EHHADH(1), HADHA(2), SDS(2) 3220279 18 16 18 8 4 9 1 1 3 0 0.782 1.000 1.000 186 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(1), CHST11(2), CHST12(1), PAPSS2(1), SULT1A1(2), SULT1A2(2), SULT1E1(1), SULT2A1(3) 2459677 13 13 13 6 2 5 0 5 1 0 0.827 1.000 1.000 187 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(8), EIF2AK4(7), EIF2B5(3), EIF2S2(1), EIF5(3), PPP1CA(1) 3074286 23 22 23 7 9 9 0 3 2 0 0.638 1.000 1.000 188 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(4), BAK1(1), BAX(1), BCL2L1(1), BIRC2(1), BIRC3(3), CASP7(2), CASP8(2), CASP9(3), DFFB(2) 3602132 20 17 19 7 6 4 1 5 4 0 0.820 1.000 1.000 189 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(1), CDKN1A(2), EPOR(2), GRIN1(1), HIF1A(1), JAK2(4), NFKB1(2), RELA(3), SOD2(1) 3335902 17 13 17 6 2 6 2 4 3 0 0.678 1.000 1.000 190 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 9 EPX(5), LPO(2), MPO(4), PRDX1(1), PRDX6(2), TPO(10), TYR(10) 2330422 34 31 34 10 7 16 4 5 2 0 0.363 1.000 1.000 191 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 21 CSNK2A1(2), FOS(2), HRAS(5), JAK2(4), JUN(3), MAP2K1(2), MAPK3(1), MPL(2), PIK3R1(2), PLCG1(3), PRKCA(5), RAF1(1), RASA1(8), SHC1(2), SOS1(11), STAT1(2), STAT3(2), STAT5A(2) 7336805 59 48 57 10 19 15 5 8 12 0 0.0791 1.000 1.000 192 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 13 ARPC1A(4), CDC42(1), PAK1(2), PDGFRA(10), PIK3R1(2), RAC1(1), WASL(2) 2967084 22 20 21 6 11 7 1 3 0 0 0.551 1.000 1.000 193 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 12 CNR1(5), CNR2(2), DNMT1(4), MTNR1A(1), PTAFR(3), PTGDR(5), PTGER2(2), PTGER4(2), PTGFR(5), PTGIR(1), TBXA2R(2) 2766681 32 31 32 10 6 12 3 10 1 0 0.422 1.000 1.000 194 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(1), IL2RG(1), IL4(2), IL4R(2), IRS1(7), JAK1(2), JAK3(7), RPS6KB1(1), SHC1(2), STAT6(2) 3929436 27 22 27 9 5 12 1 5 4 0 0.546 1.000 1.000 195 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(1), ACOX1(2), ACOX3(5), ELOVL5(2), ELOVL6(1), FADS1(1), FADS2(1), FASN(2), HADHA(2), HSD17B12(2), PECR(1), SCD(2) 3804969 22 18 22 9 5 8 3 2 4 0 0.632 1.000 1.000 196 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), IL10(2), IL10RA(2), IL1A(1), IL6(1), JAK1(2), STAT1(2), STAT3(2), STAT5A(2), TNF(1) 3239749 17 16 17 8 6 6 1 2 2 0 0.800 1.000 1.000 197 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 6 AKT1(1), PIK3R1(2), PLCB1(8), PLCG1(3), PRKCA(5), VAV1(7) 2820210 26 25 26 8 12 9 2 2 1 0 0.608 1.000 1.000 198 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(2), IKBKAP(4), IKBKB(2), MAP3K1(3), MAP3K14(1), NFKB1(2), RELA(3), TNFAIP3(5), TRAF3(3), TRAF6(5) 4813758 30 26 30 9 5 10 1 8 6 0 0.629 1.000 1.000 199 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 16 IFNG(1), IFNGR1(4), IFNGR2(1), IKBKB(2), JAK2(4), LIN7A(1), NFKB1(2), RELA(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1), USH1C(7), WT1(4) 4140687 33 26 33 9 9 7 4 10 3 0 0.451 1.000 1.000 200 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(2), POLD2(1), POLE(7), POLG(2), POLL(2), POLQ(19) 4432425 34 27 34 8 11 13 1 7 2 0 0.236 1.000 1.000 201 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(4), BAK1(1), BAX(1), BCL2L1(1), CASP8AP2(6), CASP9(3), CES1(2) 2975887 18 14 17 6 6 3 2 6 1 0 0.822 1.000 1.000 202 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(2), FOS(2), HRAS(5), IL6(1), IL6R(1), IL6ST(1), JAK1(2), JAK2(4), JAK3(7), JUN(3), MAP2K1(2), MAPK3(1), PTPN11(3), RAF1(1), SHC1(2), SOS1(11), SRF(2), STAT3(2) 6320392 52 43 50 10 16 17 3 10 6 0 0.105 1.000 1.000 203 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM2(1), CAMK1G(3), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK4(3), CAMKK2(1), CREB1(1), SYT1(4) 3046636 16 15 16 9 3 6 4 2 1 0 0.951 1.000 1.000 204 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(2), ACADM(1), ACADS(2), ACADVL(1), ACSL1(2), ACSL3(2), ACSL4(2), CPT1A(5), CPT2(2), DCI(1), EHHADH(1), HADHA(2), PECR(1), SCP2(1), SLC25A20(1) 4455792 26 26 26 7 4 7 2 8 5 0 0.494 1.000 1.000 205 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(3), FDFT1(1), FDPS(1), HMGCR(1), IDI1(1), LSS(2), MVD(1), PMVK(1), SC5DL(1), SQLE(3) 2935905 15 14 15 5 2 7 0 6 0 0 0.639 1.000 1.000 206 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG3(2), ATG7(6), BECN1(2), GABARAP(1), IFNA1(1), IFNA10(3), IFNA14(2), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA7(1), IFNA8(2), IFNG(1), PIK3C3(5), PIK3R4(7), PRKAA2(5), ULK1(4), ULK2(5) 5589918 53 44 52 10 21 12 4 8 8 0 0.148 1.000 1.000 207 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2) 3514241 19 19 19 7 5 12 0 1 1 0 0.650 1.000 1.000 208 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(11), AP2A1(2), AP2M1(1), CALM2(1), DNM1(2), EPN1(3), EPS15(5), PICALM(4), PPP3CA(4), PPP3CB(4), PPP3CC(2), SYNJ1(4), SYNJ2(4), SYT1(4) 5731532 51 45 50 10 17 15 4 6 9 0 0.167 1.000 1.000 209 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(5), ICAM1(2), ITGA4(4), ITGAL(1), ITGAM(7), ITGB1(5), ITGB2(5), SELE(4), SELL(2), SELP(11) 4238792 46 32 46 11 11 17 2 11 5 0 0.249 1.000 1.000 210 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACO1(2), ACO2(3), ACSS1(3), FH(2), IDH1(2), MDH1(1), MDH2(1), SUCLA2(2) 3521600 16 16 16 7 5 7 1 2 1 0 0.799 1.000 1.000 211 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(3), ATM(8), BRCA1(12), CDKN1A(2), CHEK1(5), CHEK2(3), GADD45A(1), JUN(3), MAPK8(3), MDM2(2), MRE11A(1), NFKB1(2), RAD50(3), RAD51(1), RBBP8(1), RELA(3) 7690163 53 40 52 9 19 14 2 10 8 0 0.145 1.000 1.000 212 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(8), ATR(13), BRCA1(12), CCNB1(2), CDC25B(2), CDC25C(1), CDKN1A(2), CHEK1(5), CHEK2(3), EP300(9), GADD45A(1), MDM2(2), MYT1(4), PRKDC(12), RPS6KA1(2), WEE1(4), YWHAQ(1) 11059381 83 61 82 12 23 29 6 15 10 0 0.0232 1.000 1.000 213 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(3), EGF(6), EGFR(7), HRAS(5), MAP2K1(2), MAPK1(1), MAPK3(1), PTPRB(17), RAF1(1), RASA1(8), SHC1(2), SOS1(11), SPRY2(1), SPRY3(4) 6619376 69 56 67 15 16 23 4 13 13 0 0.173 1.000 1.000 214 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 53 AKR1C4(1), AKR1D1(3), ARSD(1), ARSE(2), CARM1(1), CYP11B2(7), CYP19A1(4), HSD11B1(3), HSD11B2(1), HSD17B1(1), HSD17B12(2), HSD17B7(1), HSD3B1(6), HSD3B2(3), LCMT1(2), LCMT2(1), METTL2B(1), METTL6(2), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), SRD5A1(2), SRD5A2(2), STS(6), SULT1E1(1), SULT2A1(3), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(3), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(4), UGT2B11(5), UGT2B15(3), UGT2B28(5), UGT2B4(8), UGT2B7(2), WBSCR22(3) 12765819 130 79 130 24 31 44 10 30 15 0 0.00696 1.000 1.000 215 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 22 ABL1(3), ATM(8), ATR(13), CCNA1(1), CCND1(1), CCNE1(3), CDKN1A(2), CDKN2B(1), E2F1(2), HDAC1(2), SKP2(2), TFDP1(3), TGFB1(1), TGFB2(3) 7175386 45 36 45 9 14 20 3 5 3 0 0.179 1.000 1.000 216 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA4(1), PSMA5(1), PSMB3(1), PSMB4(2), PSMC2(4), PSMC3(2), PSMD1(4), PSMD11(1), PSMD12(1), PSMD13(1), PSMD2(1) 4216158 19 16 19 9 4 10 1 3 1 0 0.901 1.000 1.000 217 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGAP1(1), ARFGEF2(4), CLTA(1), COPA(8), GBF1(6), GPLD1(1), KDELR2(1) 4288103 23 20 23 9 10 6 0 6 1 0 0.772 1.000 1.000 218 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(2), CLOCK(5), CRY1(3), CRY2(2), CSNK1D(2), NPAS2(2), PER1(6), PER2(2), PER3(2) 4502889 26 23 26 9 7 10 3 5 1 0 0.688 1.000 1.000 219 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 190 ACTB(1), ACTG1(2), ACTN1(2), ACTN2(10), ACTN3(2), ACTN4(5), AKT1(1), AKT3(3), ARHGAP5(2), BCAR1(6), BIRC2(1), BIRC3(3), BRAF(8), CAPN2(2), CAV2(1), CAV3(1), CCND1(1), CCND2(3), CCND3(1), CDC42(1), COL11A1(45), COL11A2(13), COL1A1(11), COL1A2(15), COL2A1(12), COL3A1(16), COL4A1(11), COL4A2(14), COL4A4(11), COL4A6(10), COL5A1(7), COL5A2(14), COL5A3(13), COL6A1(1), COL6A2(7), COL6A3(13), COL6A6(21), COMP(2), CRKL(1), CTNNB1(4), DIAPH1(1), DOCK1(4), EGF(6), EGFR(7), ERBB2(2), FARP2(7), FIGF(2), FLNA(14), FLNB(3), FLNC(16), FLT1(11), FN1(20), FYN(5), GRLF1(12), HGF(10), HRAS(5), IBSP(6), IGF1(3), IGF1R(1), ILK(2), ITGA1(4), ITGA10(7), ITGA11(6), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(4), ITGA5(2), ITGA6(7), ITGA7(4), ITGA8(14), ITGA9(2), ITGAV(4), ITGB1(5), ITGB3(4), ITGB4(8), ITGB6(1), ITGB7(1), ITGB8(5), JUN(3), KDR(16), LAMA1(17), LAMA2(23), LAMA3(11), LAMA4(17), LAMA5(6), LAMB1(6), LAMB2(3), LAMB3(3), LAMB4(6), LAMC1(7), LAMC2(5), LAMC3(5), MAP2K1(2), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(3), MAPK9(1), MET(4), MYL2(2), MYL9(1), MYLK(8), MYLK2(4), MYLPF(1), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(6), PARVB(1), PARVG(2), PDGFB(1), PDGFC(2), PDGFD(1), PDGFRA(10), PDGFRB(6), PDPK1(1), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PIP5K1C(2), PPP1CA(1), PRKCA(5), PRKCG(9), PTK2(6), PXN(3), RAC1(1), RAF1(1), RAP1A(1), RAP1B(1), RAPGEF1(4), RELN(34), ROCK1(5), ROCK2(3), SHC1(2), SHC2(5), SHC3(2), SHC4(5), SOS1(11), SOS2(7), SPP1(1), THBS1(1), THBS2(16), THBS3(3), THBS4(1), TLN1(6), TLN2(14), TNC(14), TNN(21), TNR(26), TNXB(19), VASP(2), VAV1(7), VAV2(4), VAV3(1), VCL(2), VEGFC(6), VWF(17), ZYX(1) 97580064 1020 173 1015 310 276 407 67 153 117 0 0.298 1.000 1.000 220 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 232 ADCYAP1R1(9), ADORA1(3), ADORA2A(5), ADORA3(1), ADRA1A(2), ADRA1B(3), ADRA2B(6), ADRA2C(2), ADRB1(1), ADRB2(4), AGTR1(5), AGTR2(3), AVPR1A(3), AVPR1B(2), AVPR2(3), BDKRB1(3), BDKRB2(3), C3AR1(2), C5AR1(4), CALCR(10), CALCRL(4), CCKAR(2), CCKBR(2), CGA(2), CHRM2(9), CHRM3(5), CHRM4(1), CHRM5(3), CNR1(5), CNR2(2), CRHR1(4), CRHR2(3), CTSG(3), CYSLTR1(2), CYSLTR2(1), DRD1(1), DRD2(4), DRD3(5), DRD4(1), DRD5(3), EDNRA(1), EDNRB(5), F2R(2), F2RL1(3), F2RL2(1), F2RL3(1), FPR1(1), FSHB(2), FSHR(15), GABBR1(5), GABBR2(3), GABRA1(7), GABRA3(4), GABRA4(5), GABRA5(6), GABRB1(4), GABRB2(6), GABRB3(11), GABRD(2), GABRE(4), GABRG1(15), GABRG2(4), GABRG3(10), GABRP(3), GABRQ(7), GABRR1(4), GABRR2(4), GALR1(5), GH1(2), GH2(4), GHR(3), GHRHR(4), GHSR(4), GLP1R(1), GLP2R(5), GLRA1(2), GLRA2(5), GLRA3(3), GLRB(3), GPR156(4), GPR35(1), GPR50(5), GPR63(4), GPR83(2), GRIA1(9), GRIA2(7), GRIA3(11), GRIA4(10), GRID1(15), GRID2(15), GRIK1(5), GRIK2(9), GRIK3(10), GRIK4(4), GRIK5(2), GRIN1(1), GRIN2A(16), GRIN2B(18), GRIN2C(3), GRIN2D(4), GRIN3A(10), GRIN3B(4), GRM1(13), GRM2(3), GRM3(14), GRM4(3), GRM5(12), GRM6(6), GRM7(10), GRM8(14), GRPR(3), GZMA(4), HCRTR2(3), HRH1(3), HRH2(2), HRH3(1), HRH4(4), HTR1A(8), HTR1B(3), HTR1E(5), HTR1F(3), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(3), HTR5A(4), HTR6(2), HTR7(4), LEPR(15), LHB(1), LHCGR(9), LTB4R2(1), MAS1(3), MC2R(2), MC3R(2), MC4R(2), MC5R(3), MCHR1(2), MCHR2(6), MLNR(2), MTNR1A(1), NMBR(3), NMUR2(2), NPBWR1(4), NPBWR2(3), NPFFR2(8), NPY1R(3), NPY2R(4), NPY5R(4), NR3C1(1), NTSR1(4), NTSR2(4), OPRD1(2), OPRK1(1), OPRL1(2), OPRM1(6), OXTR(1), P2RX2(4), P2RX3(5), P2RX4(1), P2RX5(1), P2RX7(2), P2RY1(2), P2RY10(5), P2RY13(1), P2RY14(3), P2RY2(3), P2RY4(3), P2RY6(2), P2RY8(2), PARD3(7), PPYR1(4), PRL(1), PRLHR(2), PRLR(6), PRSS1(4), PRSS3(2), PTAFR(3), PTGDR(5), PTGER2(2), PTGER3(5), PTGER4(2), PTGFR(5), PTGIR(1), PTH2R(6), RXFP1(8), RXFP2(3), SCTR(1), SSTR1(3), SSTR2(2), SSTR3(2), SSTR4(2), SSTR5(1), TAAR1(5), TAAR2(4), TAAR5(5), TAAR6(5), TAAR8(3), TAAR9(3), TACR1(3), TACR2(1), TACR3(4), TBXA2R(2), THRA(1), THRB(2), TRHR(2), TRPV1(3), TSHR(5), VIPR2(3) 57822819 880 170 877 306 192 372 76 148 92 0 0.0981 1.000 1.000 221 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(10), ADCY2(18), ADCY3(7), ADCY4(4), ADCY7(7), ADCY8(18), ADCY9(3), ADORA2A(5), ADRA1A(2), ADRA1B(3), ADRA1D(3), ADRB1(1), ADRB2(4), AGTR1(5), ATP2A1(1), ATP2A2(3), ATP2A3(3), ATP2B1(4), ATP2B2(7), ATP2B3(3), ATP2B4(3), AVPR1A(3), AVPR1B(2), BDKRB1(3), BDKRB2(3), BST1(1), CACNA1A(11), CACNA1B(10), CACNA1C(18), CACNA1D(6), CACNA1E(19), CACNA1F(10), CACNA1G(7), CACNA1H(5), CACNA1I(12), CACNA1S(7), CALM2(1), CALML6(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK4(3), CCKAR(2), CCKBR(2), CD38(2), CHP(2), CHRM2(9), CHRM3(5), CHRM5(3), CHRNA7(1), CYSLTR1(2), CYSLTR2(1), DRD1(1), EDNRA(1), EDNRB(5), EGFR(7), ERBB2(2), ERBB3(4), ERBB4(13), F2R(2), GNA11(1), GNA14(3), GNAL(1), GNAS(6), GRIN1(1), GRIN2A(16), GRIN2C(3), GRIN2D(4), GRM1(13), GRM5(12), GRPR(3), HRH1(3), HRH2(2), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(3), HTR5A(4), HTR6(2), HTR7(4), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(14), ITPR3(3), LHCGR(9), LTB4R2(1), MYLK(8), MYLK2(4), NOS1(11), NOS3(2), NTSR1(4), OXTR(1), P2RX2(4), P2RX3(5), P2RX4(1), P2RX5(1), P2RX7(2), PDE1A(2), PDE1B(3), PDE1C(13), PDGFRA(10), PDGFRB(6), PHKA1(6), PHKA2(4), PHKB(6), PHKG1(2), PHKG2(1), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PLCD1(1), PLCD3(1), PLCE1(14), PLCG1(3), PLCG2(5), PLCZ1(5), PLN(1), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), PRKACB(3), PRKACG(1), PRKCA(5), PRKCG(9), PRKX(1), PTAFR(3), PTGER3(5), PTGFR(5), RYR1(28), RYR2(120), RYR3(52), SLC25A5(1), SLC25A6(1), SLC8A1(15), SLC8A2(3), SLC8A3(3), SPHK2(1), TACR1(3), TACR2(1), TACR3(4), TBXA2R(2), TNNC1(1), TRHR(2), TRPC1(6), VDAC1(1) 71573339 874 169 869 271 196 379 56 150 91 2 0.0128 1.000 1.000 222 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(1), ACTG1(2), COL11A1(45), COL11A2(13), COL17A1(4), COL1A1(11), COL1A2(15), COL2A1(12), COL3A1(16), COL4A1(11), COL4A2(14), COL4A4(11), COL4A6(10), COL5A1(7), COL5A2(14), COL5A3(13), COL6A1(1), COL6A2(7), COL6A3(13), COL6A6(21), COMP(2), DES(3), DSC1(8), DSC2(1), DSC3(6), DSG1(9), DSG2(3), DSG3(4), DSG4(8), FN1(20), GJA1(4), GJA10(7), GJA4(1), GJA5(1), GJA8(4), GJA9(4), GJB2(1), GJB4(3), GJC1(3), GJC2(1), GJD2(2), GJD4(2), IBSP(6), INA(2), ITGA6(7), ITGB4(8), KRT1(1), KRT10(1), KRT12(3), KRT13(4), KRT14(3), KRT15(1), KRT16(3), KRT17(2), KRT18(2), KRT2(5), KRT20(2), KRT23(4), KRT24(3), KRT27(2), KRT28(2), KRT3(2), KRT31(2), KRT32(2), KRT33A(1), KRT35(1), KRT36(2), KRT37(2), KRT39(1), KRT4(2), KRT40(2), KRT5(1), KRT6A(2), KRT6B(3), KRT6C(1), KRT71(3), KRT72(4), KRT73(6), KRT74(2), KRT75(1), KRT76(3), KRT77(5), KRT79(2), KRT8(1), KRT81(3), KRT82(2), KRT83(2), KRT84(4), KRT85(2), KRT86(1), KRT9(2), LAMA1(17), LAMA2(23), LAMA3(11), LAMA4(17), LAMA5(6), LAMB1(6), LAMB2(3), LAMB3(3), LAMB4(6), LAMC1(7), LAMC2(5), LAMC3(5), NES(13), PRPH(3), RELN(34), SPP1(1), THBS1(1), THBS2(16), THBS3(3), THBS4(1), TNC(14), TNN(21), TNR(26), TNXB(19), VIM(7), VWF(17) 65915247 751 168 749 227 205 299 57 107 83 0 0.230 1.000 1.000 223 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 246 ACVR1B(3), ACVR1C(4), AKT1(1), AKT3(3), ARRB1(2), ATF2(3), ATF4(2), BDNF(1), BRAF(8), CACNA1A(11), CACNA1B(10), CACNA1C(18), CACNA1D(6), CACNA1E(19), CACNA1F(10), CACNA1G(7), CACNA1H(5), CACNA1I(12), CACNA1S(7), CACNA2D1(10), CACNA2D2(3), CACNA2D3(3), CACNA2D4(8), CACNB1(1), CACNB2(5), CACNB3(2), CACNB4(1), CACNG2(1), CACNG3(4), CACNG4(1), CACNG6(1), CACNG7(4), CACNG8(2), CD14(2), CDC25B(2), CDC42(1), CHP(2), CHUK(2), CRKL(1), DAXX(3), DUSP10(5), DUSP16(2), DUSP4(2), DUSP5(5), DUSP6(2), DUSP7(1), DUSP8(1), EGF(6), EGFR(7), ELK4(1), FAS(1), FASLG(1), FGF10(2), FGF12(3), FGF14(2), FGF18(1), FGF19(1), FGF2(2), FGF22(1), FGF23(2), FGF3(1), FGF5(3), FGF6(2), FGF8(1), FGFR1(1), FGFR2(4), FGFR3(4), FGFR4(2), FLNA(14), FLNB(3), FLNC(16), FOS(2), GADD45A(1), GADD45B(1), GADD45G(1), GNA12(2), GNG12(1), HRAS(5), IKBKB(2), IL1A(1), IL1B(1), IL1R1(1), IL1R2(3), JUN(3), JUND(2), KRAS(2), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(1), MAP2K5(1), MAP2K6(2), MAP2K7(1), MAP3K1(3), MAP3K12(4), MAP3K13(5), MAP3K14(1), MAP3K3(1), MAP3K4(4), MAP3K5(4), MAP3K6(1), MAP3K7(2), MAP4K1(3), MAP4K2(1), MAP4K3(7), MAP4K4(6), MAPK1(1), MAPK10(1), MAPK11(2), MAPK13(2), MAPK14(1), MAPK3(1), MAPK7(1), MAPK8(3), MAPK8IP1(2), MAPK8IP3(4), MAPK9(1), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(3), MAPT(4), MEF2C(4), MKNK2(1), MOS(4), MRAS(2), MYC(1), NF1(22), NFATC2(4), NFATC4(2), NFKB1(2), NFKB2(2), NLK(2), NR4A1(3), NRAS(1), NTF3(3), NTRK1(4), NTRK2(1), PAK1(2), PAK2(1), PDGFB(1), PDGFRA(10), PDGFRB(6), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PPM1A(2), PPM1B(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), PRKACB(3), PRKACG(1), PRKCA(5), PRKCG(9), PRKX(1), PTPN5(1), PTPN7(1), PTPRR(9), RAC1(1), RAF1(1), RAP1A(1), RAP1B(1), RAPGEF2(8), RASA1(8), RASA2(3), RASGRF1(7), RASGRF2(7), RASGRP1(1), RASGRP2(1), RASGRP3(8), RASGRP4(5), RPS6KA1(2), RPS6KA2(7), RPS6KA3(1), RPS6KA4(2), RPS6KA5(4), RPS6KA6(5), RRAS2(2), SOS1(11), SOS2(7), SRF(2), STK3(2), STK4(2), TAOK1(7), TAOK2(5), TAOK3(4), TGFB1(1), TGFB2(3), TGFBR2(3), TNF(1), TNFRSF1A(2), TRAF6(5) 75628935 679 165 672 222 186 256 40 108 89 0 0.382 1.000 1.000 224 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 130 ACTB(1), ACTG1(2), ACTN1(2), ACTN2(10), ACTN3(2), ACTN4(5), AKT1(1), AKT3(3), AMOTL1(3), ASH1L(9), CASK(2), CDC42(1), CGN(4), CLDN1(2), CLDN10(4), CLDN11(1), CLDN16(4), CLDN17(1), CLDN18(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN4(1), CLDN5(1), CLDN6(1), CLDN8(1), CLDN9(3), CSDA(5), CSNK2A1(2), CTNNA1(1), CTNNA2(27), CTNNA3(17), CTNNB1(4), CTTN(5), EPB41(3), EPB41L1(3), EPB41L2(3), EPB41L3(20), EXOC3(3), EXOC4(3), F11R(1), GNAI1(3), GNAI3(1), HCLS1(3), HRAS(5), IGSF5(2), INADL(13), JAM2(2), KRAS(2), LLGL1(1), LLGL2(3), MAGI1(8), MAGI2(12), MAGI3(2), MLLT4(4), MPDZ(6), MPP5(4), MRAS(2), MYH1(24), MYH10(1), MYH11(8), MYH13(12), MYH14(5), MYH15(18), MYH2(33), MYH3(6), MYH4(21), MYH6(14), MYH7(13), MYH7B(7), MYH8(24), MYH9(13), MYL2(2), MYL9(1), MYLPF(1), NRAS(1), PARD3(7), PARD6A(1), PARD6G(1), PPP2R1A(8), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(2), PPP2R3A(3), PPP2R4(1), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCI(5), PRKCQ(4), PRKCZ(1), RAB3B(2), RRAS2(2), SPTAN1(4), SYMPK(8), TJAP1(4), TJP1(9), TJP2(3), TJP3(2), VAPA(1), YES1(1) 51296061 535 165 533 160 153 190 39 88 65 0 0.317 1.000 1.000 225 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(4), CD36(1), CD44(5), CD47(2), COL11A1(45), COL11A2(13), COL1A1(11), COL1A2(15), COL2A1(12), COL3A1(16), COL4A1(11), COL4A2(14), COL4A4(11), COL4A6(10), COL5A1(7), COL5A2(14), COL5A3(13), COL6A1(1), COL6A2(7), COL6A3(13), COL6A6(21), DAG1(2), FN1(20), FNDC1(8), FNDC3A(1), GP5(4), GP6(2), GP9(2), HMMR(2), HSPG2(11), IBSP(6), ITGA1(4), ITGA10(7), ITGA11(6), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(4), ITGA5(2), ITGA6(7), ITGA7(4), ITGA8(14), ITGA9(2), ITGAV(4), ITGB1(5), ITGB3(4), ITGB4(8), ITGB6(1), ITGB7(1), ITGB8(5), LAMA1(17), LAMA2(23), LAMA3(11), LAMA4(17), LAMA5(6), LAMB1(6), LAMB2(3), LAMB3(3), LAMB4(6), LAMC1(7), LAMC2(5), LAMC3(5), RELN(34), SDC2(2), SDC3(1), SPP1(1), SV2A(3), SV2B(4), SV2C(4), THBS1(1), THBS2(16), THBS3(3), THBS4(1), TNC(14), TNN(21), TNR(26), TNXB(19), VWF(17) 59383761 666 160 664 197 179 269 43 100 75 0 0.262 1.000 1.000 226 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ADCY1(10), ADCY2(18), ADCY3(7), ADCY4(4), ADCY5(2), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), ADRA1A(2), ADRA1B(3), ADRA1D(3), ADRB1(1), ADRB2(4), ANXA6(5), ARRB1(2), ATP1A4(6), ATP1B2(1), ATP1B3(1), ATP2A2(3), ATP2A3(3), ATP2B1(4), ATP2B2(7), ATP2B3(3), CACNA1A(11), CACNA1B(10), CACNA1C(18), CACNA1D(6), CACNA1E(19), CACNA1S(7), CACNB1(1), CACNB3(2), CALM2(1), CALR(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK4(3), CASQ1(1), CASQ2(3), CHRM2(9), CHRM3(5), CHRM4(1), CHRM5(3), GJA1(4), GJA4(1), GJA5(1), GJB2(1), GJB4(3), GNA11(1), GNAI3(1), GNAZ(3), GNB1(1), GNB2(1), GNB3(2), GNB4(3), GNB5(1), GNG12(1), GNG4(2), GNG5(1), GRK4(1), GRK5(1), GRK6(1), ITPR1(6), ITPR2(14), ITPR3(3), KCNB1(1), KCNJ5(2), MIB1(2), NME7(3), PEA15(1), PKIB(1), PLCB3(4), PLN(1), PRKACB(3), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCQ(4), PRKCZ(1), PRKD1(11), RGS1(3), RGS10(1), RGS11(1), RGS16(1), RGS17(2), RGS18(1), RGS19(1), RGS20(1), RGS3(6), RGS5(3), RGS6(5), RGS7(14), RGS9(2), RYR1(28), RYR2(120), RYR3(52), SFN(2), SLC8A1(15), SLC8A3(3), USP5(2), YWHAB(1), YWHAQ(1) 49779690 601 158 597 188 132 254 40 111 62 2 0.0701 1.000 1.000 227 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 202 ACTN1(2), ACTN2(10), ACTN3(2), ACTN4(5), APC(9), APC2(2), ARAF(3), ARHGEF1(2), ARHGEF12(5), ARHGEF4(3), ARHGEF6(2), ARHGEF7(3), ARPC1A(4), BAIAP2(2), BCAR1(6), BDKRB1(3), BDKRB2(3), BRAF(8), CD14(2), CDC42(1), CFL1(2), CFL2(1), CHRM2(9), CHRM3(5), CHRM4(1), CHRM5(3), CRKL(1), CYFIP1(5), CYFIP2(6), DIAPH1(1), DIAPH2(4), DIAPH3(5), DOCK1(4), EGF(6), EGFR(7), F2R(2), FGD1(3), FGD3(2), FGF10(2), FGF12(3), FGF14(2), FGF18(1), FGF19(1), FGF2(2), FGF22(1), FGF23(2), FGF3(1), FGF5(3), FGF6(2), FGF8(1), FGFR1(1), FGFR2(4), FGFR3(4), FGFR4(2), FN1(20), GIT1(1), GNA12(2), GNA13(1), GNG12(1), GRLF1(12), GSN(2), HRAS(5), IQGAP1(8), IQGAP2(6), IQGAP3(11), ITGA1(4), ITGA10(7), ITGA11(6), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(4), ITGA5(2), ITGA6(7), ITGA7(4), ITGA8(14), ITGA9(2), ITGAD(7), ITGAE(4), ITGAL(1), ITGAM(7), ITGAV(4), ITGAX(9), ITGB1(5), ITGB2(5), ITGB3(4), ITGB4(8), ITGB6(1), ITGB7(1), ITGB8(5), KRAS(2), LIMK2(3), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MOS(4), MRAS(2), MSN(4), MYH10(1), MYH14(5), MYH9(13), MYL2(2), MYL9(1), MYLK(8), MYLK2(4), MYLPF(1), NCKAP1(7), NCKAP1L(12), NRAS(1), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(6), PDGFB(1), PDGFRA(10), PDGFRB(6), PFN2(1), PFN3(1), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PIP4K2A(3), PIP4K2B(2), PIP4K2C(3), PIP5K1A(4), PIP5K1B(2), PIP5K1C(2), PPP1CA(1), PPP1R12B(5), PTK2(6), PXN(3), RAC1(1), RAF1(1), RDX(2), ROCK1(5), ROCK2(3), RRAS2(2), SCIN(1), SLC9A1(3), SOS1(11), SOS2(7), SSH1(1), SSH2(8), SSH3(1), TIAM1(11), TIAM2(5), VAV1(7), VAV2(4), VAV3(1), VCL(2), WAS(3), WASF1(1), WASL(2) 72640706 620 157 615 187 185 214 28 120 73 0 0.222 1.000 1.000 228 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(3), ADCY1(10), ADCY2(18), ADCY3(7), ADCY4(4), ADCY5(2), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), ARRB1(2), ATF2(3), ATF3(1), ATF4(2), ATP2A2(3), ATP2A3(3), CACNB3(2), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CNN1(2), CORIN(11), CREB3(2), CRHR1(4), DGKZ(4), FOS(2), GABPA(2), GABPB2(2), GJA1(4), GNB1(1), GNB2(1), GNB3(2), GNB4(3), GNB5(1), GNG12(1), GNG4(2), GNG5(1), GRK4(1), GRK5(1), GRK6(1), GSTO1(1), GUCY1A3(7), IGFBP3(2), IGFBP6(2), IL1B(1), IL6(1), ITPR1(6), ITPR2(14), ITPR3(3), JUN(3), MIB1(2), MYL2(2), MYL4(1), MYLK2(4), NFKB1(2), NOS1(11), NOS3(2), OXTR(1), PDE4B(3), PDE4D(2), PKIB(1), PLCB3(4), PLCD1(1), PLCG1(3), PLCG2(5), PRKACB(3), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(3), PRKCQ(4), PRKCZ(1), PRKD1(11), RAMP2(1), RGS1(3), RGS10(1), RGS11(1), RGS16(1), RGS17(2), RGS18(1), RGS19(1), RGS20(1), RGS3(6), RGS5(3), RGS6(5), RGS7(14), RGS9(2), RYR1(28), RYR2(120), RYR3(52), SFN(2), SLC8A1(15), SP1(2), TNXB(19), USP5(2), YWHAB(1), YWHAQ(1) 46011111 546 156 540 164 135 215 40 99 55 2 0.0753 1.000 1.000 229 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 126 ABL1(3), ABLIM1(2), ABLIM2(2), ABLIM3(3), ARHGEF12(5), CDC42(1), CDK5(1), CFL1(2), CFL2(1), CHP(2), CXCR4(5), DCC(15), DPYSL2(1), DPYSL5(8), EFNA3(1), EFNB1(3), EFNB2(2), EPHA1(3), EPHA2(2), EPHA3(11), EPHA4(1), EPHA5(16), EPHA6(14), EPHA7(9), EPHA8(6), EPHB1(13), EPHB2(6), EPHB3(8), EPHB4(3), EPHB6(5), FYN(5), GNAI1(3), GNAI3(1), HRAS(5), ITGB1(5), KRAS(2), L1CAM(1), LIMK2(3), MAPK1(1), MAPK3(1), MET(4), NCK1(2), NCK2(2), NFAT5(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NGEF(1), NRAS(1), NRP1(5), NTN1(3), NTN4(2), NTNG1(1), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(6), PLXNA1(10), PLXNA2(3), PLXNA3(5), PLXNB1(3), PLXNB2(4), PLXNB3(4), PLXNC1(9), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), PTK2(6), RAC1(1), RASA1(8), RGS3(6), ROBO1(10), ROBO2(9), ROBO3(7), ROCK1(5), ROCK2(3), SEMA3A(4), SEMA3B(1), SEMA3C(5), SEMA3D(3), SEMA3E(5), SEMA3F(2), SEMA3G(3), SEMA4A(1), SEMA4B(1), SEMA4C(2), SEMA4D(1), SEMA4F(6), SEMA5A(9), SEMA5B(6), SEMA6B(1), SEMA6C(5), SEMA6D(8), SEMA7A(1), SLIT1(4), SLIT2(15), SLIT3(10), SRGAP1(5), SRGAP2(4), SRGAP3(5), UNC5A(5), UNC5B(2), UNC5C(8), UNC5D(19) 51716628 481 153 480 191 105 190 33 87 65 1 0.979 1.000 1.000 230 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 161 ADORA1(3), ADORA2A(5), ADORA3(1), ADRA1A(2), ADRA1B(3), ADRA1D(3), ADRA2C(2), ADRB1(1), ADRB2(4), AGTR1(5), AGTR2(3), AVPR1A(3), AVPR1B(2), AVPR2(3), BDKRB1(3), BDKRB2(3), C3AR1(2), CCBP2(4), CCKAR(2), CCKBR(2), CCR1(3), CCR10(1), CCR2(1), CCR3(1), CCR4(3), CCR5(1), CCR6(2), CCR8(1), CCR9(1), CCRL1(3), CCRL2(1), CHML(2), CHRM2(9), CHRM3(5), CHRM4(1), CHRM5(3), CMKLR1(2), CNR1(5), CNR2(2), CX3CR1(3), CXCR3(1), CXCR4(5), DRD1(1), DRD2(4), DRD3(5), DRD4(1), DRD5(3), EDNRA(1), EDNRB(5), F2R(2), F2RL1(3), F2RL2(1), F2RL3(1), FPR1(1), FSHR(15), GALR1(5), GALT(1), GHSR(4), GPR17(4), GPR173(1), GPR174(6), GPR27(1), GPR35(1), GPR37(3), GPR37L1(2), GPR50(5), GPR6(2), GPR63(4), GPR77(2), GPR83(2), GPR85(2), GPR87(4), GRPR(3), HCRTR2(3), HRH1(3), HRH2(2), HRH3(1), HTR1A(8), HTR1B(3), HTR1E(5), HTR1F(3), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(3), HTR5A(4), HTR6(2), HTR7(4), LHCGR(9), MAS1(3), MC3R(2), MC4R(2), MC5R(3), MLNR(2), MTNR1A(1), NMBR(3), NMUR2(2), NPY1R(3), NPY2R(4), NPY5R(4), NTSR1(4), NTSR2(4), OPN1SW(3), OPN3(2), OPRD1(2), OPRK1(1), OPRL1(2), OPRM1(6), OR10A5(2), OR11A1(4), OR12D3(4), OR1C1(9), OR1F1(1), OR1Q1(2), OR2H1(2), OR5V1(3), OR8B8(6), OXTR(1), P2RY1(2), P2RY10(5), P2RY13(1), P2RY14(3), P2RY2(3), P2RY6(2), PPYR1(4), PTAFR(3), PTGDR(5), PTGER2(2), PTGER4(2), PTGFR(5), PTGIR(1), RGR(1), RHO(1), SSTR1(3), SSTR2(2), SSTR3(2), SSTR4(2), SUCNR1(2), TBXA2R(2), TRHR(2) 31895855 408 152 408 158 80 172 27 85 44 0 0.360 1.000 1.000 231 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(3), ACTN2(10), ACTN3(2), ACTN4(5), DES(3), DMD(34), FAM48A(2), MYBPC1(9), MYBPC3(6), MYH3(6), MYH6(14), MYH7(13), MYH8(24), MYL1(3), MYL2(2), MYL3(2), MYL4(1), MYL9(1), MYOM1(12), NEB(30), TNNI2(2), TNNI3(2), TNNT1(1), TNNT2(2), TNNT3(3), TPM1(1), TPM3(1), TTN(333), VIM(7) 36469866 534 150 532 173 142 199 36 100 54 3 0.951 1.000 1.000 232 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 143 APC(9), APC2(2), AXIN2(2), BTRC(1), CACYBP(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CCND1(1), CCND2(3), CCND3(1), CER1(2), CHD8(9), CHP(2), CREBBP(17), CSNK1A1(2), CSNK1A1L(5), CSNK2A1(2), CTBP1(2), CTNNB1(4), CUL1(4), CXXC4(1), DAAM1(1), DAAM2(7), DKK1(4), DKK2(1), DKK4(1), DVL1(2), DVL3(2), EP300(9), FBXW11(1), FOSL1(1), FZD1(1), FZD10(2), FZD2(1), FZD3(5), FZD4(1), FZD6(3), FZD7(3), FZD8(1), FZD9(2), JUN(3), LEF1(3), LRP5(6), LRP6(6), MAP3K7(2), MAPK10(1), MAPK8(3), MAPK9(1), MYC(1), NFAT5(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NKD1(2), NKD2(2), NLK(2), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PORCN(2), PPARD(2), PPP2R1A(8), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), PRICKLE1(7), PRICKLE2(3), PRKACB(3), PRKACG(1), PRKCA(5), PRKCG(9), PRKX(1), PSEN1(3), RAC1(1), RBX1(1), ROCK1(5), ROCK2(3), RUVBL1(4), SENP2(3), SFRP4(4), SFRP5(1), SIAH1(1), SKP1(1), SMAD2(2), SMAD3(1), SMAD4(5), TBL1XR1(2), TBL1Y(2), TCF7(1), TCF7L2(1), VANGL1(1), VANGL2(2), WIF1(6), WNT1(1), WNT10A(1), WNT10B(4), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT3A(2), WNT5A(1), WNT5B(1), WNT6(1), WNT7A(3), WNT7B(1), WNT8A(2), WNT9A(1), WNT9B(1) 42587073 335 143 333 122 87 142 25 44 37 0 0.872 1.000 1.000 233 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY1(10), ADCY2(18), ADCY3(7), ADCY4(4), ADCY5(2), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), ADSL(1), ADSS(1), ADSSL1(2), AK2(1), AK5(7), AK7(3), ALLC(3), AMPD1(4), AMPD2(1), AMPD3(7), ATIC(1), CANT1(1), DCK(1), ENPP1(8), ENPP3(6), ENTPD1(1), ENTPD2(2), ENTPD3(1), ENTPD5(1), ENTPD6(4), ENTPD8(1), GART(3), GDA(7), GUCY1A2(12), GUCY1A3(7), GUCY1B3(4), GUCY2C(5), GUCY2D(2), GUCY2F(6), GUK1(2), HPRT1(1), IMPDH1(2), IMPDH2(1), NME4(1), NME7(3), NPR1(3), NPR2(4), NT5C1A(2), NT5C1B(2), NT5C2(3), NT5C3(3), NT5E(2), NUDT9(2), PAPSS2(1), PDE10A(9), PDE11A(12), PDE1A(2), PDE1C(13), PDE2A(4), PDE3B(5), PDE4A(1), PDE4B(3), PDE4C(4), PDE4D(2), PDE5A(4), PDE6H(3), PDE7A(1), PDE7B(1), PDE8A(5), PDE8B(3), PDE9A(2), PFAS(5), PKLR(4), PKM2(3), PNPT1(2), POLA1(7), POLD1(2), POLD2(1), POLD3(1), POLE(7), POLE2(2), POLE4(1), POLR1A(3), POLR1B(2), POLR1D(1), POLR2A(2), POLR2B(6), POLR2D(1), POLR2E(2), POLR3A(1), POLR3B(1), POLR3G(1), POLR3H(2), PPAT(2), PRIM1(3), PRIM2(14), PRPS1(2), PRPS1L1(3), PRPS2(1), RFC5(1), RRM1(1), RRM2(1), RRM2B(3), XDH(11) 43376730 379 141 378 138 96 147 21 60 55 0 0.869 1.000 1.000 234 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1B(3), ACVR2A(4), AMHR2(7), BMPR1A(3), BMPR1B(1), BMPR2(1), CCL14(2), CCL16(1), CCL20(1), CCL26(2), CCL28(1), CCL3(2), CCL7(1), CCR1(3), CCR2(1), CCR3(1), CCR4(3), CCR5(1), CCR6(2), CCR8(1), CCR9(1), CD27(1), CD40(2), CD40LG(3), CNTFR(1), CSF1(2), CSF1R(3), CSF2RA(7), CSF2RB(5), CSF3R(7), CX3CR1(3), CXCL14(1), CXCL5(2), CXCR3(1), CXCR4(5), EDA2R(1), EDAR(2), EGF(6), EGFR(7), EPOR(2), FAS(1), FASLG(1), FLT1(11), FLT3(7), FLT4(5), GDF5(4), GH1(2), GH2(4), GHR(3), HGF(10), IFNA1(1), IFNA10(3), IFNA14(2), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IFNG(1), IFNGR1(4), IFNGR2(1), IL10(2), IL10RA(2), IL11RA(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(4), IL13RA1(2), IL17A(1), IL17RA(6), IL18R1(2), IL18RAP(4), IL19(1), IL1A(1), IL1B(1), IL1R1(1), IL1R2(3), IL1RAP(2), IL20RA(1), IL21(1), IL21R(3), IL22(2), IL22RA1(1), IL22RA2(1), IL23R(2), IL28B(2), IL28RA(1), IL2RB(2), IL2RG(1), IL3(1), IL4(2), IL4R(2), IL5RA(3), IL6(1), IL6R(1), IL6ST(1), IL7(1), IL7R(8), IL9R(6), INHBA(5), INHBB(1), INHBC(1), KDR(16), KIT(7), LEPR(15), LIFR(3), LTA(2), LTB(1), LTBR(1), MET(4), MPL(2), NGFR(1), OSMR(5), PDGFB(1), PDGFC(2), PDGFRA(10), PDGFRB(6), PF4(1), PLEKHO2(5), PRL(1), PRLR(6), TGFB1(1), TGFB2(3), TGFBR2(3), TNF(1), TNFRSF10A(1), TNFRSF10B(1), TNFRSF11A(2), TNFRSF11B(1), TNFRSF13B(2), TNFRSF17(1), TNFRSF18(1), TNFRSF19(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(3), TNFRSF6B(1), TNFRSF8(1), TNFRSF9(1), TNFSF11(1), TNFSF13(1), TNFSF14(1), TNFSF15(1), TNFSF18(1), TPO(10), VEGFC(6), XCL1(1), XCR1(2) 46853372 405 140 402 162 97 149 24 84 50 1 0.989 1.000 1.000 235 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 91 ADCY1(10), ADCY2(18), ADCY3(7), ADCY4(4), ADCY5(2), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), ADRB1(1), CSNK1D(2), DRD1(1), DRD2(4), EGF(6), EGFR(7), GJA1(4), GJD2(2), GNA11(1), GNAI1(3), GNAI3(1), GNAS(6), GRM1(13), GRM5(12), GUCY1A2(12), GUCY1A3(7), GUCY1B3(4), GUCY2C(5), GUCY2D(2), GUCY2F(6), HRAS(5), HTR2A(3), HTR2B(1), HTR2C(5), ITPR1(6), ITPR2(14), ITPR3(3), KRAS(2), MAP2K1(2), MAP2K2(1), MAP2K5(1), MAPK1(1), MAPK3(1), MAPK7(1), NPR1(3), NPR2(4), NRAS(1), PDGFB(1), PDGFC(2), PDGFD(1), PDGFRA(10), PDGFRB(6), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PRKACB(3), PRKACG(1), PRKCA(5), PRKCG(9), PRKG1(6), PRKG2(4), PRKX(1), RAF1(1), SOS1(11), SOS2(7), TJP1(9), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3D(2), TUBA3E(5), TUBA4A(1), TUBA8(1), TUBAL3(3), TUBB(1), TUBB1(1), TUBB2A(2), TUBB3(2), TUBB4(4), TUBB4Q(2), TUBB8(1) 34823843 354 140 351 107 83 130 28 70 43 0 0.214 1.000 1.000 236 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(3), CADM1(2), CADM3(4), CD2(1), CD22(6), CD226(5), CD276(2), CD34(2), CD4(1), CD40(2), CD40LG(3), CD58(1), CD6(2), CD80(3), CD86(3), CD8A(2), CD8B(1), CD99(2), CDH1(3), CDH15(2), CDH2(10), CDH3(1), CDH4(6), CDH5(3), CLDN1(2), CLDN10(4), CLDN11(1), CLDN16(4), CLDN17(1), CLDN18(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN4(1), CLDN5(1), CLDN6(1), CLDN8(1), CLDN9(3), CNTN1(12), CNTN2(1), CNTNAP1(4), CNTNAP2(32), CTLA4(1), ESAM(4), F11R(1), GLG1(3), HLA-A(6), HLA-B(1), HLA-C(1), HLA-DMA(1), HLA-DMB(1), HLA-DOA(1), HLA-DOB(1), HLA-DPA1(2), HLA-DQA2(1), HLA-DRA(1), HLA-DRB1(2), HLA-DRB5(2), HLA-G(2), ICAM1(2), ICAM3(2), ICOS(2), ITGA4(4), ITGA6(7), ITGA8(14), ITGA9(2), ITGAL(1), ITGAM(7), ITGAV(4), ITGB1(5), ITGB2(5), ITGB7(1), ITGB8(5), JAM2(2), L1CAM(1), MADCAM1(1), MAG(4), NCAM1(4), NCAM2(15), NEGR1(2), NEO1(8), NFASC(7), NLGN1(15), NLGN2(1), NLGN3(4), NRCAM(6), NRXN1(23), NRXN2(10), NRXN3(10), PDCD1(1), PTPRC(7), PTPRF(7), PTPRM(6), PVR(1), PVRL1(3), PVRL3(3), SDC2(2), SDC3(1), SELE(4), SELL(2), SELP(11), SELPLG(1), SIGLEC1(9), VCAM1(5), VCAN(23) 39075264 434 139 433 172 138 148 32 76 39 1 0.975 1.000 1.000 237 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 150 AKT1(1), AKT3(3), BCL2L1(1), CBL(3), CBLB(7), CCND1(1), CCND2(3), CCND3(1), CNTFR(1), CREBBP(17), CSF2RA(7), CSF2RB(5), CSF3R(7), EP300(9), EPOR(2), GH1(2), GH2(4), GHR(3), IFNA1(1), IFNA10(3), IFNA14(2), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IFNG(1), IFNGR1(4), IFNGR2(1), IL10(2), IL10RA(2), IL11RA(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(4), IL13RA1(2), IL13RA2(1), IL19(1), IL20RA(1), IL21(1), IL21R(3), IL22(2), IL22RA1(1), IL22RA2(1), IL23R(2), IL28B(2), IL28RA(1), IL2RB(2), IL2RG(1), IL3(1), IL4(2), IL4R(2), IL5RA(3), IL6(1), IL6R(1), IL6ST(1), IL7(1), IL7R(8), IL9R(6), JAK1(2), JAK2(4), JAK3(7), LEPR(15), LIFR(3), MPL(2), MYC(1), OSMR(5), PIAS1(5), PIAS2(2), PIAS3(3), PIAS4(2), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PIM1(2), PRL(1), PRLR(6), PTPN11(3), SOCS2(2), SOCS3(1), SOCS4(2), SOCS5(3), SOS1(11), SOS2(7), SPRED1(3), SPRED2(1), SPRY2(1), SPRY3(4), STAM(3), STAM2(2), STAT1(2), STAT2(1), STAT3(2), STAT4(5), STAT5A(2), STAT6(2), TPO(10), TYK2(8) 37909142 336 136 333 114 100 104 26 63 43 0 0.831 1.000 1.000 238 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 130 ACACA(2), ACACB(9), AKT1(1), AKT3(3), ARAF(3), BRAF(8), CALM2(1), CALML6(1), CBL(3), CBLB(7), CRKL(1), EXOC7(1), FASN(2), FBP2(1), FLOT1(1), FLOT2(1), G6PC(3), G6PC2(3), GCK(5), GYS1(1), GYS2(4), HRAS(5), IKBKB(2), INPP5D(8), INSR(10), IRS1(7), IRS2(1), IRS4(3), KRAS(2), LIPE(1), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(3), MAPK9(1), MKNK2(1), NRAS(1), PCK1(3), PCK2(1), PDE3A(8), PDE3B(5), PDPK1(1), PFKL(2), PFKM(6), PFKP(2), PHKA1(6), PHKA2(4), PHKB(6), PHKG1(2), PHKG2(1), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PKLR(4), PKM2(3), PPARGC1A(5), PPP1CA(1), PPP1R3A(16), PPP1R3C(2), PPP1R3D(2), PRKAA2(5), PRKAB2(1), PRKACB(3), PRKACG(1), PRKAG2(4), PRKAG3(3), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCI(5), PRKCZ(1), PRKX(1), PTPN1(1), PTPRF(7), PYGB(3), PYGL(3), PYGM(6), RAF1(1), RAPGEF1(4), RHEB(1), RPS6(1), RPS6KB1(1), RPS6KB2(1), SH2B2(1), SHC1(2), SHC2(5), SHC3(2), SHC4(5), SLC2A4(2), SOCS2(2), SOCS3(1), SOCS4(2), SORBS1(5), SOS1(11), SOS2(7), SREBF1(2), TRIP10(2), TSC1(5), TSC2(5) 41809354 348 136 347 122 101 126 23 47 50 1 0.727 1.000 1.000 239 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(10), ADCY2(18), ADCY3(7), ADCY4(4), ADCY5(2), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), ATF4(2), CACNA1C(18), CACNA1D(6), CACNA1F(10), CACNA1S(7), CALM2(1), CALML6(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CDC42(1), CGA(2), EGFR(7), FSHB(2), GNA11(1), GNAS(6), HBEGF(1), HRAS(5), ITPR1(6), ITPR2(14), ITPR3(3), JUN(3), KRAS(2), LHB(1), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP2K7(1), MAP3K1(3), MAP3K3(1), MAP3K4(4), MAPK1(1), MAPK10(1), MAPK11(2), MAPK13(2), MAPK14(1), MAPK3(1), MAPK7(1), MAPK8(3), MAPK9(1), MMP14(2), MMP2(3), NRAS(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PLD1(7), PLD2(2), PRKACB(3), PRKACG(1), PRKCA(5), PRKCD(2), PRKX(1), RAF1(1), SOS1(11), SOS2(7) 33804548 296 136 292 101 70 122 20 55 29 0 0.576 1.000 1.000 240 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(10), ADCY8(18), ARAF(3), ATF4(2), BRAF(8), CACNA1C(18), CALM2(1), CALML6(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK4(3), CHP(2), CREBBP(17), EP300(9), GRIA1(9), GRIA2(7), GRIN1(1), GRIN2A(16), GRIN2B(18), GRIN2C(3), GRIN2D(4), GRM1(13), GRM5(12), HRAS(5), ITPR1(6), ITPR2(14), ITPR3(3), KRAS(2), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), NRAS(1), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PPP1CA(1), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), PRKACB(3), PRKACG(1), PRKCA(5), PRKCG(9), PRKX(1), RAF1(1), RAP1A(1), RAP1B(1), RAPGEF3(1), RPS6KA1(2), RPS6KA2(7), RPS6KA3(1), RPS6KA6(5) 26447306 292 133 288 101 64 118 29 48 33 0 0.661 1.000 1.000 241 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(3), BRAF(8), C7orf16(2), CACNA1A(11), CRHR1(4), GNA11(1), GNA12(2), GNA13(1), GNAI1(3), GNAI3(1), GNAS(6), GNAZ(3), GRIA1(9), GRIA2(7), GRIA3(11), GRID2(15), GRM1(13), GRM5(12), GUCY1A2(12), GUCY1A3(7), GUCY1B3(4), GUCY2C(5), GUCY2D(2), GUCY2F(6), HRAS(5), IGF1(3), IGF1R(1), ITPR1(6), ITPR2(14), ITPR3(3), KRAS(2), LYN(2), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), NOS1(11), NOS3(2), NPR1(3), NPR2(4), NRAS(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PPP2R1A(8), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(2), PRKCA(5), PRKCG(9), PRKG1(6), PRKG2(4), RAF1(1), RYR1(28) 29214472 323 133 321 98 81 117 28 52 45 0 0.228 1.000 1.000 242 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 106 ABL1(3), ANAPC1(5), ANAPC4(3), ANAPC5(5), ATM(8), ATR(13), BUB1(4), BUB1B(6), BUB3(2), CCNA1(1), CCNA2(1), CCNB1(2), CCNB2(1), CCNB3(11), CCND1(1), CCND2(3), CCND3(1), CCNE1(3), CCNE2(2), CDC14A(1), CDC14B(2), CDC16(1), CDC20(1), CDC23(1), CDC25B(2), CDC25C(1), CDC27(3), CDC6(6), CDC7(3), CDK7(1), CDKN1A(2), CDKN2B(1), CDKN2C(1), CHEK1(5), CHEK2(3), CREBBP(17), CUL1(4), DBF4(4), E2F1(2), EP300(9), ESPL1(4), GADD45A(1), GADD45B(1), GADD45G(1), HDAC1(2), MAD1L1(7), MAD2L1(2), MCM2(1), MCM3(1), MCM4(5), MCM5(6), MCM6(3), MCM7(3), MDM2(2), ORC1L(3), ORC2L(1), ORC3L(2), ORC5L(3), PKMYT1(1), PLK1(2), PRKDC(12), PTTG1(2), PTTG2(2), RBL1(5), RBL2(8), RBX1(1), SFN(2), SKP1(1), SKP2(2), SMAD2(2), SMAD3(1), SMAD4(5), SMC1A(2), SMC1B(9), TFDP1(3), TGFB1(1), TGFB2(3), WEE1(4), YWHAB(1), YWHAQ(1) 35369181 263 130 262 63 91 80 17 41 34 0 0.116 1.000 1.000 243 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(11), ABCA10(10), ABCA12(7), ABCA13(34), ABCA2(10), ABCA3(4), ABCA4(11), ABCA5(5), ABCA6(7), ABCA7(4), ABCA8(6), ABCA9(13), ABCB1(18), ABCB10(6), ABCB11(6), ABCB4(8), ABCB5(14), ABCB6(3), ABCB7(2), ABCB8(1), ABCB9(3), ABCC1(5), ABCC10(8), ABCC11(6), ABCC12(15), ABCC2(6), ABCC3(2), ABCC4(1), ABCC5(8), ABCC6(1), ABCC8(6), ABCC9(10), ABCD1(3), ABCD2(12), ABCD4(1), ABCG1(1), ABCG2(2), ABCG4(4), ABCG5(2), ABCG8(7), CFTR(8), TAP1(3), TAP2(1) 31371140 295 129 293 102 81 97 17 69 29 2 0.567 1.000 1.000 244 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(2), ACTB(1), ACTG1(2), ACTN1(2), ACTN2(10), ACTN3(2), ACTN4(5), ACVR1B(3), ACVR1C(4), BAIAP2(2), CDC42(1), CDH1(3), CREBBP(17), CSNK2A1(2), CTNNA1(1), CTNNA2(27), CTNNA3(17), CTNNB1(4), CTNND1(4), EGFR(7), EP300(9), ERBB2(2), FARP2(7), FER(3), FGFR1(1), FYN(5), IGF1R(1), INSR(10), IQGAP1(8), LEF1(3), LMO7(7), MAP3K7(2), MAPK1(1), MAPK3(1), MET(4), MLLT4(4), NLK(2), PARD3(7), PTPN1(1), PTPRB(17), PTPRF(7), PTPRJ(4), PTPRM(6), PVRL1(3), PVRL3(3), PVRL4(6), RAC1(1), SMAD2(2), SMAD3(1), SMAD4(5), SNAI1(4), SNAI2(3), SORBS1(5), SSX2IP(2), TCF7(1), TCF7L2(1), TGFBR2(3), TJP1(9), VCL(2), WAS(3), WASF1(1), WASF3(1), WASL(2), YES1(1) 31739977 287 128 285 95 79 95 19 60 34 0 0.791 1.000 1.000 245 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY1(10), ADCY2(18), ADCY3(7), ADCY4(4), ADCY5(2), ADCY6(2), ADCY7(7), ADCY8(18), ADSL(1), ADSS(1), AK2(1), AK5(7), ALLC(3), AMPD1(4), AMPD2(1), AMPD3(7), ATIC(1), ATP5A1(3), ATP5B(2), ATP5C1(3), ATP5G2(2), ATP5G3(1), CANT1(1), DCK(1), ENPP1(8), ENPP3(6), ENTPD1(1), ENTPD2(2), GART(3), GDA(7), GUCY1A2(12), GUCY1A3(7), GUCY1B3(4), GUCY2C(5), GUCY2D(2), GUCY2F(6), GUK1(2), HPRT1(1), IMPDH1(2), IMPDH2(1), NPR1(3), NPR2(4), NT5E(2), PAPSS2(1), PDE1A(2), PDE4A(1), PDE4B(3), PDE4C(4), PDE4D(2), PDE5A(4), PDE6B(3), PDE6C(1), PDE7B(1), PDE8A(5), PDE9A(2), PFAS(5), PKLR(4), PKM2(3), POLB(1), POLD1(2), POLD2(1), POLE(7), POLG(2), POLL(2), POLQ(19), POLR1B(2), POLR2A(2), POLR2B(6), POLR2D(1), POLR2E(2), POLRMT(2), PPAT(2), PRPS1(2), PRPS1L1(3), PRPS2(1), RRM1(1), RRM2(1) 34024956 285 128 285 93 75 105 16 54 35 0 0.504 1.000 1.000 246 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 ACTN1(2), ACTN2(10), ACTN3(2), ACTN4(5), ARHGAP5(2), BCAR1(6), CD99(2), CDC42(1), CDH5(3), CLDN1(2), CLDN10(4), CLDN11(1), CLDN16(4), CLDN17(1), CLDN18(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN4(1), CLDN5(1), CLDN6(1), CLDN8(1), CLDN9(3), CTNNA1(1), CTNNA2(27), CTNNA3(17), CTNNB1(4), CTNND1(4), CXCR4(5), CYBB(6), ESAM(4), F11R(1), GNAI1(3), GNAI3(1), GRLF1(12), ICAM1(2), ITGA4(4), ITGAL(1), ITGAM(7), ITGB1(5), ITGB2(5), ITK(2), JAM2(2), MAPK11(2), MAPK13(2), MAPK14(1), MLLT4(4), MMP2(3), MMP9(5), MSN(4), MYL2(2), MYL9(1), MYLPF(1), NCF2(3), NCF4(1), NOX1(2), NOX3(6), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLCG1(3), PLCG2(5), PRKCA(5), PRKCG(9), PTK2(6), PTPN11(3), PXN(3), RAC1(1), RAP1A(1), RAP1B(1), RAPGEF3(1), RAPGEF4(6), RASSF5(1), RHOH(4), ROCK1(5), ROCK2(3), THY1(2), TXK(3), VASP(2), VAV1(7), VAV2(4), VAV3(1), VCAM1(5), VCL(2) 32325019 327 126 327 110 92 132 21 50 32 0 0.620 1.000 1.000 247 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(6), ALG1(1), ALG10B(1), ALG12(1), ALG13(8), ALG2(3), ALG6(2), ALG8(1), ALG9(1), B3GNT2(1), B3GNT6(1), B3GNT7(1), B4GALT1(1), B4GALT3(3), B4GALT4(3), B4GALT5(2), C1GALT1C1(1), CHPF(2), CHST1(3), CHST11(2), CHST12(1), CHST2(5), CHST3(2), CHST4(2), CHST6(5), CHSY1(2), DDOST(1), EXT1(2), EXT2(1), EXTL1(5), EXTL2(1), EXTL3(1), FUT8(2), GALNT1(2), GALNT10(3), GALNT11(2), GALNT12(3), GALNT13(14), GALNT14(4), GALNT2(2), GALNT3(3), GALNT5(7), GALNT6(2), GALNT8(3), GALNT9(1), GALNTL1(4), GALNTL4(4), GALNTL5(3), GANAB(5), GCNT1(3), GCNT3(2), HS3ST2(2), HS3ST3A1(1), HS3ST5(4), HS6ST1(5), HS6ST3(3), MAN1A1(4), MAN1A2(5), MAN1C1(3), MAN2A1(5), MGAT1(2), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT4B(1), MGAT5(6), MGAT5B(3), NDST1(4), NDST2(2), NDST3(4), NDST4(13), OGT(2), RPN1(1), ST3GAL1(4), ST3GAL4(2), ST6GAL1(2), ST6GALNAC1(3), STT3B(1), UST(1), WBSCR17(12), XYLT1(6) 29153233 250 125 248 87 67 103 18 39 23 0 0.612 1.000 1.000 248 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(9), BDKRB1(3), BDKRB2(3), C1QA(2), C1QB(2), C1R(3), C1S(3), C2(2), C3(5), C3AR1(2), C4BPA(2), C5(1), C5AR1(4), C6(18), C7(12), C8A(7), C8B(4), C9(3), CD46(2), CD55(1), CFB(3), CFH(7), CFI(3), CPB2(3), CR1(6), CR2(12), F10(3), F11(3), F12(1), F13A1(6), F13B(13), F2R(2), F3(1), F5(18), F7(2), F8(10), F9(7), FGA(5), FGB(4), FGG(2), KLKB1(7), KNG1(9), MASP1(9), MASP2(1), MBL2(4), PLAT(1), PLAU(2), PLAUR(2), PLG(2), PROS1(5), SERPINA1(1), SERPINA5(3), SERPINC1(7), SERPIND1(2), SERPINF2(3), SERPING1(3), VWF(17) 24083078 277 125 277 84 71 108 22 49 26 1 0.483 1.000 1.000 249 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVR1B(3), ACVRL1(3), AKT1(1), BMPR1A(3), BMPR2(1), BUB1(4), CDKL1(1), CDKL2(2), CDS1(2), CLK1(3), CLK2(2), CLK4(2), COL4A3BP(3), CSNK2A1(2), DGKA(3), DGKB(6), DGKD(6), DGKE(4), DGKG(3), DGKQ(1), DGKZ(4), IMPA1(2), INPP1(1), INPP4A(4), INPP4B(6), INPP5A(4), INPPL1(4), ITPKA(1), ITPKB(6), MOS(4), NEK1(3), OCRL(8), PAK4(1), PIK3C2A(7), PIK3C2B(7), PIK3C2G(8), PIK3CB(4), PIK3CG(19), PIM2(2), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PLCD1(1), PLCG1(3), PLCG2(5), PLK3(3), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCQ(4), PRKCZ(1), PRKD1(11), PRKG1(6), RAF1(1), RPS6KA1(2), RPS6KA2(7), RPS6KA3(1), RPS6KA4(2), RPS6KB1(1), STK11(3), VRK1(1) 29417143 256 124 255 73 73 92 19 40 32 0 0.293 1.000 1.000 250 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 71 CALM2(1), CALML6(1), CDS1(2), DGKA(3), DGKB(6), DGKD(6), DGKE(4), DGKG(3), DGKI(13), DGKQ(1), DGKZ(4), FN3K(1), IMPA1(2), INPP1(1), INPP4A(4), INPP4B(6), INPP5A(4), INPP5B(7), INPP5D(8), INPP5E(2), INPPL1(4), ITPK1(3), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(14), ITPR3(3), OCRL(8), PI4KA(8), PI4KB(1), PIK3C2A(7), PIK3C2B(7), PIK3C2G(8), PIK3C3(5), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PIP4K2A(3), PIP4K2B(2), PIP4K2C(3), PIP5K1A(4), PIP5K1B(2), PIP5K1C(2), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PLCD1(1), PLCD3(1), PLCE1(14), PLCG1(3), PLCG2(5), PLCZ1(5), PRKCA(5), PRKCG(9), SYNJ1(4), SYNJ2(4) 32324174 288 122 286 81 82 108 15 43 40 0 0.115 1.000 1.000 251 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 124 ARAF(3), BRAF(8), CD244(3), CHP(2), FAS(1), FASLG(1), FCER1G(1), FCGR3A(4), FCGR3B(2), FYN(5), GZMB(1), HLA-A(6), HLA-B(1), HLA-C(1), HLA-G(2), HRAS(5), ICAM1(2), IFNA1(1), IFNA10(3), IFNA14(2), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IFNG(1), IFNGR1(4), IFNGR2(1), ITGAL(1), ITGB2(5), KIR2DL1(2), KIR2DL3(4), KIR2DL4(1), KIR3DL1(6), KIR3DL2(1), KLRC1(1), KLRC3(2), KLRD1(1), KRAS(2), LCK(3), LCP2(2), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), NCR1(6), NCR2(1), NFAT5(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NRAS(1), PAK1(2), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLCG1(3), PLCG2(5), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), PRF1(1), PRKCA(5), PRKCG(9), PTPN11(3), RAC1(1), RAF1(1), SH2D1A(2), SHC1(2), SHC2(5), SHC3(2), SHC4(5), SOS1(11), SOS2(7), SYK(1), TNF(1), TNFRSF10A(1), TNFRSF10B(1), TYROBP(3), ULBP1(2), ULBP3(1), VAV1(7), VAV2(4), VAV3(1), ZAP70(5) 29270970 277 122 275 88 83 106 16 37 34 1 0.422 1.000 1.000 252 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(1), AKT3(3), BCAR1(6), CAPN1(2), CAPN10(4), CAPN11(2), CAPN2(2), CAPN3(8), CAPN5(2), CAPN6(7), CAPN7(1), CAPN9(2), CAV2(1), CAV3(1), CDC42(1), DOCK1(4), FYN(5), ILK(2), ITGA10(7), ITGA11(6), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(4), ITGA5(2), ITGA6(7), ITGA7(4), ITGA8(14), ITGA9(2), ITGAD(7), ITGAE(4), ITGAL(1), ITGAM(7), ITGAV(4), ITGAX(9), ITGB1(5), ITGB2(5), ITGB3(4), ITGB4(8), ITGB6(1), ITGB7(1), ITGB8(5), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K6(2), MAPK10(1), MAPK4(2), MAPK6(4), MAPK7(1), MYLK2(4), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PDPK1(1), PIK3R2(4), PTK2(6), PXN(3), RAC1(1), RAP1B(1), RAPGEF1(4), RHO(1), ROCK1(5), ROCK2(3), SDCCAG8(6), SHC1(2), SHC3(2), SORBS1(5), SOS1(11), TLN1(6), TNS1(5), VASP(2), VAV2(4), VAV3(1), VCL(2), ZYX(1) 35619810 271 122 270 102 77 103 20 46 25 0 0.888 1.000 1.000 253 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(9), ASH2L(4), CARM1(1), CTCFL(2), DOT1L(5), EED(2), EHMT1(5), EHMT2(1), EZH1(4), EZH2(4), FBXO11(6), HCFC1(1), HSF4(1), JMJD6(1), KDM6A(7), MEN1(3), MLL(5), MLL2(41), MLL3(28), MLL4(10), MLL5(4), NSD1(10), OGT(2), PPP1CA(1), PRDM2(6), PRDM7(1), PRDM9(14), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), RBBP5(1), SATB1(4), SETD1A(8), SETD2(5), SETD8(1), SETDB1(3), SMYD3(1), STK38(4), SUV39H1(2), SUV39H2(2), SUV420H1(6), SUZ12(4), WHSC1(1), WHSC1L1(16) 31533699 249 121 248 60 69 76 11 37 55 1 0.141 1.000 1.000 254 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 91 ADCY1(10), ADCY2(18), ADCY3(7), ADCY4(4), ADCY5(2), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), AKAP1(2), AKAP11(8), AKAP12(4), AKAP3(8), AKAP4(6), AKAP5(1), AKAP6(15), AKAP7(2), AKAP8(5), AKAP9(11), ARHGEF1(2), CALM2(1), CHMP1B(1), GNA11(1), GNA12(2), GNA13(1), GNA14(3), GNAI3(1), GNAL(1), GNAZ(3), GNB1(1), GNB2(1), GNB3(2), GNB5(1), GNG12(1), GNG4(2), GNG5(1), HRAS(5), ITPR1(6), KRAS(2), NRAS(1), PDE1A(2), PDE1B(3), PDE1C(13), PDE4A(1), PDE4B(3), PDE4C(4), PDE4D(2), PDE7A(1), PDE7B(1), PDE8A(5), PDE8B(3), PLCB3(4), PPP3CA(4), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCI(5), PRKCQ(4), PRKCZ(1), PRKD1(11), PRKD3(2), SLC9A1(3), USP5(2) 30768211 278 119 276 68 80 100 18 47 33 0 0.0231 1.000 1.000 255 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(10), ADCY2(18), ADCY3(7), ADCY4(4), ADCY5(2), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), CALM2(1), CALML6(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CREB1(1), CREB3(2), CREB3L2(2), CREB3L3(1), CREB3L4(2), CREBBP(17), CTNNB1(4), DCT(4), DVL1(2), DVL3(2), EDNRB(5), EP300(9), FZD1(1), FZD10(2), FZD2(1), FZD3(5), FZD4(1), FZD6(3), FZD7(3), FZD8(1), FZD9(2), GNAI1(3), GNAI3(1), GNAS(6), HRAS(5), KIT(7), KRAS(2), LEF1(3), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), NRAS(1), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), POMC(2), PRKACB(3), PRKACG(1), PRKCA(5), PRKCG(9), PRKX(1), RAF1(1), TCF7(1), TCF7L2(1), TYR(10), TYRP1(2), WNT1(1), WNT10A(1), WNT10B(4), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT3A(2), WNT5A(1), WNT5B(1), WNT6(1), WNT7A(3), WNT7B(1), WNT8A(2), WNT9A(1), WNT9B(1) 28796144 267 119 265 86 53 113 25 53 23 0 0.349 1.000 1.000 256 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1B(3), ACVR1C(4), ACVR2A(4), ACVRL1(3), AMHR2(7), BMP4(1), BMP5(8), BMPR1A(3), BMPR1B(1), BMPR2(1), CDKN2B(1), CHRD(6), COMP(2), CREBBP(17), CUL1(4), DCN(1), E2F5(2), EP300(9), GDF5(4), GDF6(3), ID2(1), ID4(1), IFNG(1), INHBA(5), INHBB(1), INHBC(1), LEFTY2(3), LTBP1(16), MAPK1(1), MAPK3(1), MYC(1), NODAL(3), PITX2(3), PPP2R1A(8), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(2), RBL1(5), RBL2(8), RBX1(1), ROCK1(5), ROCK2(3), RPS6KB1(1), RPS6KB2(1), SKP1(1), SMAD1(3), SMAD2(2), SMAD3(1), SMAD4(5), SMAD7(2), SMAD9(1), SMURF1(2), SP1(2), TFDP1(3), TGFB1(1), TGFB2(3), TGFBR2(3), THBS1(1), THBS2(16), THBS3(3), THBS4(1), TNF(1), ZFYVE16(3), ZFYVE9(6) 26188844 220 118 218 66 62 76 14 38 30 0 0.496 1.000 1.000 257 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 75 ABL1(3), ACTN1(2), AKT1(1), AKT3(3), ARHGEF6(2), ARHGEF7(3), BCAR1(6), BRAF(8), CDC42(1), CSE1L(4), DOCK1(4), EPHB2(6), FYN(5), GRLF1(12), ILK(2), ITGA1(4), ITGA10(7), ITGA11(6), ITGA2(5), ITGA3(1), ITGA4(4), ITGA5(2), ITGA6(7), ITGA7(4), ITGA8(14), ITGA9(2), ITGB3BP(1), MAP2K4(1), MAP2K7(1), MAP3K11(2), MAPK1(1), MAPK10(1), MAPK8(3), MAPK8IP1(2), MAPK8IP3(4), MAPK9(1), MRAS(2), MYLK(8), MYLK2(4), P4HB(5), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(6), PIK3CB(4), PKLR(4), PLCG1(3), PLCG2(5), PTK2(6), RAF1(1), RALA(3), RHO(1), ROCK1(5), ROCK2(3), SHC1(2), SOS1(11), SOS2(7), TLN1(6), TLN2(14), VASP(2), WAS(3), ZYX(1) 31564622 247 110 247 86 77 83 11 46 30 0 0.793 1.000 1.000 258 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 79 ABL1(3), ATM(8), BUB1(4), BUB1B(6), BUB3(2), CCNA1(1), CCNA2(1), CCNB1(2), CCNB2(1), CCNB3(11), CCND2(3), CCND3(1), CCNE1(3), CCNE2(2), CDAN1(3), CDC14A(1), CDC14B(2), CDC20(1), CDC25B(2), CDC25C(1), CDC6(6), CDC7(3), CDH1(3), CDKN1A(2), CHEK1(5), CHEK2(3), DTX4(2), E2F1(2), E2F5(2), EP300(9), ESPL1(4), GADD45A(1), HDAC1(2), HDAC3(1), HDAC4(5), HDAC5(1), HDAC8(1), MAD1L1(7), MAD2L1(2), MCM2(1), MCM3(1), MCM4(5), MCM5(6), MCM6(3), MCM7(3), MDM2(2), MPEG1(6), MPL(2), ORC1L(3), ORC2L(1), ORC3L(2), ORC5L(3), PLK1(2), PRKDC(12), PTTG1(2), PTTG2(2), RBL1(5), SKP2(2), SMAD4(5), TBC1D8(1), TFDP1(3), TGFB1(1), WEE1(4) 28467261 196 109 195 48 61 63 13 31 28 0 0.105 1.000 1.000 259 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 78 AGL(6), AMY2B(7), ASCC3(10), ATP13A2(1), DDX18(2), DDX19A(1), DDX23(3), DDX4(2), DDX41(2), DDX50(1), DDX51(1), DDX52(1), DDX54(3), DDX55(1), DDX56(1), ENPP1(8), ENPP3(6), ENTPD7(2), EP400(9), ERCC3(1), G6PC(3), G6PC2(3), GANC(4), GBA(4), GBE1(2), GCK(5), GPI(5), GUSB(2), GYS1(1), GYS2(4), HK1(2), HK2(5), HK3(5), IFIH1(4), MGAM(5), MOV10L1(7), NUDT8(1), PGM1(1), PYGB(3), PYGL(3), PYGM(6), RAD54L(1), SETX(12), SKIV2L2(2), SMARCA2(4), TREH(1), UGDH(2), UGP2(4), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(3), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(4), UGT2B11(5), UGT2B15(3), UGT2B28(5), UGT2B4(8), UGT2B7(2), UXS1(4) 31347648 226 109 226 76 57 80 21 42 26 0 0.770 1.000 1.000 260 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 84 ABL1(3), ABL2(7), AKT1(1), AKT3(3), ARAF(3), AREG(3), BRAF(8), BTC(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CBL(3), CBLB(7), CDKN1A(2), CRKL(1), EGF(6), EGFR(7), ERBB2(2), ERBB3(4), ERBB4(13), EREG(1), GAB1(3), HBEGF(1), HRAS(5), JUN(3), KRAS(2), MAP2K1(2), MAP2K2(1), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(3), MAPK9(1), MYC(1), NCK1(2), NCK2(2), NRAS(1), NRG1(3), NRG2(2), NRG3(8), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(6), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLCG1(3), PLCG2(5), PRKCA(5), PRKCG(9), PTK2(6), RAF1(1), RPS6KB1(1), RPS6KB2(1), SHC1(2), SHC2(5), SHC3(2), SHC4(5), SOS1(11), SOS2(7), STAT5A(2), TGFA(1) 26626536 238 107 235 73 72 93 11 34 28 0 0.382 1.000 1.000 261 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(7), CD14(2), CD19(2), CD1A(5), CD1B(5), CD1C(5), CD1D(4), CD1E(4), CD2(1), CD22(6), CD33(3), CD34(2), CD36(1), CD37(3), CD38(2), CD3D(1), CD4(1), CD44(5), CD5(2), CD55(1), CD7(1), CD8A(2), CD8B(1), CD9(1), CR1(6), CR2(12), CSF1(2), CSF1R(3), CSF2RA(7), CSF3R(7), DNTT(2), EPOR(2), FCER2(1), FCGR1A(1), FLT3(7), GP5(4), GP9(2), HLA-DRA(1), HLA-DRB1(2), HLA-DRB5(2), IL11RA(1), IL1A(1), IL1B(1), IL1R1(1), IL1R2(3), IL3(1), IL4(2), IL4R(2), IL5RA(3), IL6(1), IL6R(1), IL7(1), IL7R(8), IL9R(6), ITGA1(4), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(4), ITGA5(2), ITGA6(7), ITGAM(7), ITGB3(4), KIT(7), MME(10), MS4A1(2), TFRC(2), TNF(1), TPO(10) 21663912 228 107 227 79 51 85 10 56 26 0 0.802 1.000 1.000 262 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 91 AKT1(1), AKT3(3), CARD11(5), CBL(3), CBLB(7), CD3D(1), CD4(1), CD40LG(3), CD8A(2), CD8B(1), CDC42(1), CHP(2), CHUK(2), CTLA4(1), FOS(2), FYN(5), GRAP2(1), HRAS(5), ICOS(2), IFNG(1), IKBKB(2), IL10(2), IL4(2), ITK(2), JUN(3), KRAS(2), LCK(3), LCP2(2), MALT1(1), MAP3K14(1), NCK1(2), NCK2(2), NFAT5(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NRAS(1), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(6), PDCD1(1), PDK1(1), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), PRKCQ(4), PTPRC(7), RASGRP1(1), SOS1(11), SOS2(7), TEC(4), TNF(1), VAV1(7), VAV2(4), VAV3(1), ZAP70(5) 26305462 219 107 217 62 68 71 16 35 29 0 0.295 1.000 1.000 263 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 61 AKT1(1), AKT3(3), BLNK(1), BTK(7), CARD11(5), CD19(2), CD22(6), CD79A(1), CD81(2), CHP(2), CHUK(2), CR2(12), FCGR2B(3), FOS(2), HRAS(5), IKBKB(2), INPP5D(8), JUN(3), KRAS(2), LILRB3(4), LYN(2), MALT1(1), NFAT5(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NRAS(1), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLCG2(5), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), RAC1(1), RASGRP3(8), SYK(1), VAV1(7), VAV2(4), VAV3(1) 19142126 180 107 178 54 50 61 13 26 30 0 0.389 1.000 1.000 264 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(3), AKT1(1), BDKRB2(3), CALM2(1), CHRNA1(4), FLT1(11), FLT4(5), KDR(16), NOS3(2), PDE2A(4), PDE3A(8), PDE3B(5), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKG1(6), PRKG2(4), RYR2(120), SLC7A1(4), SYT1(4) 10823358 212 107 210 62 45 84 18 37 27 1 0.266 1.000 1.000 265 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 91 CD2BP2(3), CDC40(2), CLK2(2), CLK3(1), CLK4(2), COL2A1(12), CPSF1(4), CPSF2(3), CPSF3(2), CPSF4(2), CSTF2(2), CSTF2T(3), CSTF3(1), DDX1(6), DHX15(3), DHX16(3), DHX38(2), DHX8(2), DHX9(2), DICER1(13), FUS(1), METTL3(1), NCBP1(2), NONO(1), NXF1(2), PAPOLA(1), POLR2A(2), PPM1G(1), PRPF3(1), PRPF4(2), PRPF4B(6), PRPF8(7), PSKH1(1), PTBP2(3), RBM17(1), RBM5(2), RNMT(2), RNPS1(1), SF3A1(1), SF3A2(1), SF3A3(2), SF3B1(4), SF3B2(4), SF3B4(1), SF4(4), SFRS12(1), SFRS14(5), SFRS2(2), SFRS6(1), SFRS7(2), SFRS8(2), SFRS9(1), SNRPA(2), SNRPA1(1), SNRPB(3), SNRPD1(2), SNRPD2(1), SNRPD3(1), SNRPF(1), SNRPN(5), SPOP(1), SRPK1(3), SRPK2(1), SRRM1(4), SUPT5H(2), U2AF2(1), XRN2(3) 27886092 169 105 169 43 46 63 11 31 18 0 0.283 1.000 1.000 266 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(5), AGTR2(3), ATP8A1(10), AVPR1A(3), AVPR1B(2), AVPR2(3), BDKRB1(3), BDKRB2(3), C3AR1(2), CCKAR(2), CCKBR(2), CCR1(3), CCR10(1), CCR2(1), CCR3(1), CCR4(3), CCR5(1), CCR6(2), CCR8(1), CX3CR1(3), CXCR3(1), CXCR4(5), EDNRA(1), EDNRB(5), FPR1(1), FSHR(15), GALR1(5), GALT(1), GHSR(4), GPR77(2), GRPR(3), LHCGR(9), MC2R(2), MC3R(2), MC4R(2), MC5R(3), NMBR(3), NPY1R(3), NPY2R(4), NPY5R(4), NTSR1(4), NTSR2(4), OPRD1(2), OPRK1(1), OPRL1(2), OPRM1(6), OXTR(1), PPYR1(4), SSTR1(3), SSTR2(2), SSTR3(2), SSTR4(2), TACR1(3), TACR2(1), TACR3(4), TRHR(2), TSHR(5) 13793598 177 105 177 70 30 72 11 37 27 0 0.606 1.000 1.000 267 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 73 AKT1(1), AKT3(3), BTK(7), FCER1A(4), FCER1G(1), FYN(5), GAB2(1), HRAS(5), IL3(1), IL4(2), INPP5D(8), KRAS(2), LCP2(2), LYN(2), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK11(2), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(3), MAPK9(1), MS4A2(4), NRAS(1), PDK1(1), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLCG1(3), PLCG2(5), PRKCA(5), PRKCD(2), PRKCE(3), RAC1(1), RAF1(1), SOS1(11), SOS2(7), SYK(1), TNF(1), VAV1(7), VAV2(4), VAV3(1) 18508081 183 103 182 51 48 69 17 22 27 0 0.225 1.000 1.000 268 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(1), ALG6(2), CCKBR(2), CCR2(1), CCR3(1), CCR5(1), CELSR1(11), CELSR2(8), CELSR3(9), CHRM2(9), CHRM3(5), CXCR3(1), DRD4(1), EDNRA(1), EMR2(4), EMR3(5), F2R(2), FSHR(15), GHRHR(4), GPR116(5), GPR132(1), GPR133(3), GPR135(2), GPR143(2), GPR17(4), GPR18(2), GPR55(1), GPR56(1), GPR61(2), GPR77(2), GRM1(13), GRPR(3), HRH4(4), LGR6(1), LPHN2(7), LPHN3(17), LTB4R2(1), NTSR1(4), OR2M4(4), OR8G2(3), P2RY13(1), PTGFR(5), SMO(1), SSTR2(2), TAAR5(5), TSHR(5), VN1R1(4) 17564572 188 102 188 65 52 66 14 39 17 0 0.281 1.000 1.000 269 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(1), CABIN1(5), CALM2(1), CAMK2B(1), CAMK4(3), CDKN1A(2), CNR1(5), CREBBP(17), CSNK2A1(2), CTLA4(1), EGR2(6), EGR3(2), EP300(9), FCER1A(4), FCGR3A(4), FKBP1B(1), FOS(2), FOSL1(1), GATA3(6), GRLF1(12), GSK3A(3), HRAS(5), ICOS(2), IFNA1(1), IFNB1(2), IFNG(1), IL10(2), IL1B(1), IL3(1), IL4(2), IL6(1), ITK(2), KPNA5(2), MAP2K7(1), MAPK14(1), MAPK8(3), MAPK9(1), MEF2A(2), MEF2D(3), MYF5(7), NCK2(2), NFAT5(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NPPB(1), NUP214(5), OPRD1(2), P2RX7(2), PAK1(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PTPRC(7), RELA(3), SFN(2), SLA(2), SP1(2), SP3(1), TGFB1(1), TNF(1), TRPV6(3), VAV1(7), VAV2(4), VAV3(1), XPO5(2) 24071734 207 99 205 62 54 78 15 35 25 0 0.404 1.000 1.000 270 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 97 AKT1(1), AKT3(3), CASP8(2), CCL3(2), CD14(2), CD40(2), CD80(3), CD86(3), CHUK(2), FADD(1), FOS(2), IFNA1(1), IFNA10(3), IFNA14(2), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IKBKB(2), IKBKE(3), IL12A(1), IL12B(3), IL1B(1), IL6(1), IRAK1(4), IRF3(1), JUN(3), LBP(4), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP2K7(1), MAP3K7(2), MAPK1(1), MAPK10(1), MAPK11(2), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(3), MAPK9(1), NFKB1(2), NFKB2(2), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), RAC1(1), RELA(3), SPP1(1), STAT1(2), TBK1(3), TLR1(2), TLR2(3), TLR3(2), TLR4(10), TLR5(2), TLR7(3), TLR8(4), TLR9(2), TNF(1), TOLLIP(1), TRAF3(3), TRAF6(5) 23139248 177 99 175 64 60 53 11 29 24 0 0.796 1.000 1.000 271 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(9), ACSL1(2), ACSL3(2), ACSL4(2), ACSL6(2), ADIPOQ(2), ADIPOR2(4), AKT1(1), AKT3(3), CAMKK2(1), CD36(1), CHUK(2), CPT1A(5), CPT1B(3), CPT1C(3), CPT2(2), G6PC(3), G6PC2(3), IKBKB(2), IRS1(7), IRS2(1), IRS4(3), JAK1(2), JAK2(4), JAK3(7), LEPR(15), MAPK10(1), MAPK8(3), MAPK9(1), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), PCK1(3), PCK2(1), POMC(2), PPARA(1), PPARGC1A(5), PRKAA2(5), PRKAB2(1), PRKAG2(4), PRKAG3(3), PRKCQ(4), PTPN11(3), RELA(3), RXRA(2), RXRG(7), SLC2A1(1), SLC2A4(2), SOCS3(1), STAT3(2), STK11(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TYK2(8) 21924435 168 95 167 51 44 61 10 25 28 0 0.286 1.000 1.000 272 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 68 AKT1(1), AKT3(3), CASP9(3), CDC42(1), CHP(2), HRAS(5), KDR(16), KRAS(2), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK11(2), MAPK13(2), MAPK14(1), MAPK3(1), MAPKAPK2(1), MAPKAPK3(1), NFAT5(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NOS3(2), NRAS(1), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLCG1(3), PLCG2(5), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), PRKCA(5), PRKCG(9), PTGS2(1), PTK2(6), PXN(3), RAC1(1), RAF1(1), SH2D2A(2), SHC2(5), SPHK2(1) 18470740 182 94 180 63 56 70 12 19 25 0 0.605 1.000 1.000 273 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(3), BRAF(8), CHUK(2), CREB1(1), DAXX(3), FOS(2), HRAS(5), IKBKB(2), JUN(3), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(1), MAP2K5(1), MAP2K6(2), MAP2K7(1), MAP3K1(3), MAP3K11(2), MAP3K12(4), MAP3K13(5), MAP3K14(1), MAP3K3(1), MAP3K4(4), MAP3K5(4), MAP3K6(1), MAP3K7(2), MAP3K9(3), MAP4K1(3), MAP4K2(1), MAP4K3(7), MAP4K4(6), MAP4K5(1), MAPK1(1), MAPK10(1), MAPK11(2), MAPK13(2), MAPK14(1), MAPK3(1), MAPK4(2), MAPK6(4), MAPK7(1), MAPK8(3), MAPK9(1), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(3), MEF2A(2), MEF2C(4), MEF2D(3), MKNK2(1), MYC(1), NFKB1(2), PAK1(2), PAK2(1), RAC1(1), RAF1(1), RELA(3), RPS6KA1(2), RPS6KA2(7), RPS6KA3(1), RPS6KA4(2), RPS6KA5(4), RPS6KB1(1), RPS6KB2(1), SHC1(2), SP1(2), STAT1(2), TGFB1(1), TGFB2(3), TRADD(1) 25334500 162 94 159 68 53 61 8 22 18 0 0.972 1.000 1.000 274 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 45 AKT1(1), AKT3(3), BCR(2), BLNK(1), BTK(7), CD19(2), CD22(6), CD81(2), CR2(12), DAG1(2), FLOT1(1), FLOT2(1), GSK3A(3), INPP5D(8), ITPR1(6), ITPR2(14), ITPR3(3), LYN(2), MAP4K1(3), MAPK1(1), MAPK3(1), NFATC1(3), NFATC2(4), NR0B2(1), PDK1(1), PIK3CD(4), PIK3R1(2), PLCG2(5), PPP1R13B(5), PPP3CA(4), PPP3CB(4), PPP3CC(2), PTPRC(7), RAF1(1), SHC1(2), SOS1(11), SOS2(7), SYK(1), VAV1(7) 19061132 152 93 151 58 42 53 8 26 23 0 0.870 1.000 1.000 275 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(8), CPEB1(1), EGFR(7), ERBB2(2), ERBB4(13), ETS1(2), ETV6(4), FMN2(25), KRAS(2), MAP2K1(2), MAPK1(1), MAPK3(1), NOTCH1(18), NOTCH2(9), NOTCH3(7), NOTCH4(4), PIWIL1(8), PIWIL2(4), PIWIL3(4), RAF1(1), SOS1(11), SOS2(7), SPIRE1(2), SPIRE2(6) 13750291 149 90 148 46 36 55 7 29 21 1 0.558 1.000 1.000 276 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 45 FN3K(1), IMPA1(2), INPP1(1), INPP4A(4), INPP4B(6), INPP5A(4), INPP5B(7), INPP5E(2), INPPL1(4), IPMK(2), ITPK1(3), ITPKA(1), ITPKB(6), MIOX(1), OCRL(8), PI4KA(8), PI4KB(1), PIK3C3(5), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIP4K2A(3), PIP4K2B(2), PIP4K2C(3), PIP5K1A(4), PIP5K1B(2), PIP5K1C(2), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PLCD1(1), PLCD3(1), PLCE1(14), PLCG1(3), PLCG2(5), PLCZ1(5), SYNJ1(4), SYNJ2(4) 18898769 170 89 169 51 48 60 7 30 25 0 0.322 1.000 1.000 277 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 60 AKT1(1), AKT3(3), BCL2L1(1), CDC42(1), CREB1(1), CREB3(2), CREB5(3), EBP(1), ERBB4(13), F2RL2(1), GAB1(3), GADD45A(1), GSK3A(3), IGF1(3), INPPL1(4), IRS1(7), IRS2(1), IRS4(3), MET(4), MYC(1), NOLC1(4), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(6), PARD3(7), PARD6A(1), PDK1(1), PIK3CD(4), PPP1R13B(5), PREX1(14), PTK2(6), PTPN1(1), RPS6KA1(2), RPS6KA2(7), RPS6KA3(1), RPS6KB1(1), SFN(2), SHC1(2), SLC2A4(2), SOS1(11), SOS2(7), TSC1(5), TSC2(5), YWHAB(1), YWHAQ(1) 19506200 159 89 159 57 47 58 8 25 21 0 0.814 1.000 1.000 278 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 54 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), AGPAT3(1), AGPAT4(1), AGPAT6(1), AKR1B1(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), CEL(1), DAK(1), DGAT1(1), DGAT2(3), DGKA(3), DGKB(6), DGKD(6), DGKE(4), DGKG(3), DGKI(13), DGKQ(1), DGKZ(4), GK(4), GK2(6), GLA(2), GPAM(3), LCT(18), LIPA(2), LIPC(2), LIPF(1), LIPG(3), LPL(3), MGLL(1), PNLIPRP1(4), PNLIPRP2(4), PNPLA3(1), PPAP2B(1) 15306784 124 87 124 53 33 58 3 21 9 0 0.916 1.000 1.000 279 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(2), CAD(11), CANT1(1), CDA(1), CTPS(3), CTPS2(2), DCK(1), DCTD(1), DPYD(9), DPYS(6), DTYMK(1), ENTPD1(1), ENTPD3(1), ENTPD5(1), ENTPD6(4), ENTPD8(1), NME4(1), NME7(3), NT5C1A(2), NT5C1B(2), NT5C2(3), NT5C3(3), NT5E(2), PNPT1(2), POLA1(7), POLD1(2), POLD2(1), POLD3(1), POLE(7), POLE2(2), POLE4(1), POLR1A(3), POLR1B(2), POLR1D(1), POLR2A(2), POLR2B(6), POLR2D(1), POLR2E(2), POLR3A(1), POLR3B(1), POLR3G(1), POLR3H(2), PRIM1(3), PRIM2(14), RFC5(1), RRM1(1), RRM2(1), RRM2B(3), TXNRD1(2), TXNRD2(3), UMPS(2), UPP1(3), UPP2(1), UPRT(1) 21538795 142 86 140 61 39 50 8 20 25 0 0.984 1.000 1.000 280 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 79 AIFM1(1), AKT1(1), AKT3(3), APAF1(4), ATM(8), BAX(1), BCL2L1(1), BIRC2(1), BIRC3(3), CAPN1(2), CAPN2(2), CASP10(3), CASP7(2), CASP8(2), CASP9(3), CFLAR(2), CHP(2), CHUK(2), CSF2RB(5), DFFB(2), FADD(1), FAS(1), FASLG(1), IKBKB(2), IL1A(1), IL1B(1), IL1R1(1), IL1RAP(2), IL3(1), IRAK1(4), IRAK2(1), IRAK3(4), MAP3K14(1), NFKB1(2), NFKB2(2), NTRK1(4), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), RELA(3), TNF(1), TNFRSF10A(1), TNFRSF10B(1), TNFRSF1A(2), TRADD(1) 21377877 151 86 150 59 46 50 8 22 25 0 0.921 1.000 1.000 281 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 61 ATM(8), CCNA1(1), CCNB1(2), CCND1(1), CCND2(3), CCND3(1), CCNE1(3), CCNE2(2), CDK7(1), CDKN1A(2), CDKN2B(1), CDKN2C(1), CREB3(2), CREB3L3(1), CREB3L4(2), E2F1(2), E2F5(2), GADD45A(1), MCM2(1), MCM3(1), MCM4(5), MCM5(6), MCM6(3), MCM7(3), MDM2(2), MYC(1), MYT1(4), ORC1L(3), ORC2L(1), ORC3L(2), ORC5L(3), POLE(7), POLE2(2), PRIM1(3), RBL1(5), RPA1(1), RPA2(1), TFDP1(3), TFDP2(3), TNXB(19), WEE1(4) 19528699 119 85 119 31 38 42 5 19 15 0 0.229 1.000 1.000 282 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(1), ACADL(2), ACADM(1), ACOX1(2), ACOX2(1), ACOX3(5), ACSL1(2), ACSL3(2), ACSL4(2), ACSL6(2), ADIPOQ(2), ANGPTL4(1), APOA2(1), APOA5(3), APOC3(2), CD36(1), CPT1A(5), CPT1B(3), CPT1C(3), CPT2(2), CYP27A1(1), CYP4A22(2), CYP7A1(6), CYP8B1(1), DBI(2), EHHADH(1), FABP1(1), FABP5(1), FABP6(1), FABP7(1), FADS2(1), GK(4), GK2(6), HMGCS2(3), ILK(2), LPL(3), ME1(2), MMP1(3), NR1H3(2), PCK1(3), PCK2(1), PDPK1(1), PLTP(2), PPARA(1), PPARD(2), RXRA(2), RXRG(7), SCD(2), SCP2(1), SLC27A1(1), SLC27A2(5), SLC27A4(2), SLC27A5(4), SLC27A6(5), SORBS1(5), UBC(1), UCP1(2) 17311035 133 85 133 54 26 53 10 28 16 0 0.916 1.000 1.000 283 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 61 APAF1(4), ATM(8), ATR(13), BAI1(11), BAX(1), CASP8(2), CASP9(3), CCNB1(2), CCNB2(1), CCNB3(11), CCND1(1), CCND2(3), CCND3(1), CCNE1(3), CCNE2(2), CCNG1(1), CD82(2), CDKN1A(2), CHEK1(5), CHEK2(3), DDB2(3), EI24(1), FAS(1), GADD45A(1), GADD45B(1), GADD45G(1), GTSE1(4), IGF1(3), IGFBP3(2), LRDD(1), MDM2(2), PPM1D(1), RFWD2(5), RPRM(1), RRM2(1), RRM2B(3), SERPINB5(2), SESN1(3), SESN2(2), SESN3(3), SFN(2), SIAH1(1), STEAP3(2), THBS1(1), TNFRSF10B(1), TSC2(5) 16715513 132 84 131 28 43 43 12 18 16 0 0.0572 1.000 1.000 284 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(1), ABP1(5), ACAT1(2), ACMSD(1), AFMID(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), AOC2(2), AOC3(3), AOX1(13), ASMT(1), CARM1(1), CYP1A1(7), CYP1A2(1), CYP1B1(1), DDC(6), ECHS1(1), EHHADH(1), GCDH(2), HADH(1), HADHA(2), HSD17B4(1), INMT(3), KMO(3), KYNU(3), LCMT1(2), LCMT2(1), LNX1(2), METTL2B(1), METTL6(2), NFX1(2), OGDH(3), OGDHL(6), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), TDO2(2), TPH1(2), TPH2(6), WARS(4), WARS2(2), WBSCR22(3) 16031150 127 83 127 47 27 44 6 33 17 0 0.794 1.000 1.000 285 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP4(1), BMP5(8), BTRC(1), CSNK1A1(2), CSNK1A1L(5), CSNK1D(2), CSNK1G1(2), CSNK1G2(1), DHH(1), FBXW11(1), GLI1(3), GLI2(6), GLI3(9), HHIP(3), IHH(1), LRP2(40), PRKACB(3), PRKACG(1), PRKX(1), PTCH1(5), PTCH2(5), SHH(2), SMO(1), STK36(5), SUFU(2), WNT1(1), WNT10A(1), WNT10B(4), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT3A(2), WNT5A(1), WNT5B(1), WNT6(1), WNT7A(3), WNT7B(1), WNT8A(2), WNT9A(1), WNT9B(1), ZIC2(1) 15992445 140 83 139 61 33 51 16 25 15 0 0.952 1.000 1.000 286 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(11), COL4A2(14), COL4A3(10), COL4A4(11), COL4A5(4), COL4A6(10), F10(3), F11(3), F12(1), F2R(2), F5(18), F8(10), F9(7), FGA(5), FGB(4), FGG(2), KLKB1(7), PROS1(5), SERPINC1(7), SERPING1(3) 11776850 137 83 137 32 32 61 7 21 16 0 0.264 1.000 1.000 287 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), AKR1C2(1), AKR1C3(1), AKR1C4(1), ALDH3A1(2), ALDH3B2(1), CYP1A1(7), CYP1A2(1), CYP1B1(1), CYP2B6(4), CYP2C18(2), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2F1(3), CYP2S1(1), CYP3A4(1), CYP3A43(4), CYP3A7(1), GSTA1(3), GSTA2(2), GSTA4(1), GSTA5(2), GSTM3(1), GSTM4(3), GSTM5(3), GSTP1(1), GSTZ1(2), MGST1(2), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(3), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(4), UGT2B11(5), UGT2B15(3), UGT2B28(5), UGT2B4(8), UGT2B7(2) 14910265 128 82 128 38 31 45 11 31 10 0 0.399 1.000 1.000 288 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(3), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3B2(1), ALDH7A1(1), ALDH9A1(2), ALDOA(1), ALDOB(2), BPGM(1), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(3), G6PC2(3), GAPDH(2), GAPDHS(1), GCK(5), GPI(5), HK1(2), HK2(5), HK3(5), LDHAL6A(2), LDHAL6B(1), LDHB(3), LDHC(3), PDHA1(3), PDHA2(8), PFKL(2), PFKM(6), PFKP(2), PGAM2(1), PGAM4(1), PGK1(2), PGK2(4), PGM1(1), PKLR(4), PKM2(3), TPI1(3) 15386973 113 81 113 49 30 43 8 19 13 0 0.928 1.000 1.000 289 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 42 AKT1(1), AKT3(3), ARHGAP1(1), ARHGAP4(2), ARHGEF11(6), BTK(7), CDC42(1), CFL1(2), CFL2(1), GDI1(2), GDI2(2), INPPL1(4), ITPR1(6), ITPR2(14), ITPR3(3), MYLK(8), MYLK2(4), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(6), PDK1(1), PIK3CD(4), PIK3CG(19), PIK3R1(2), PITX2(3), PPP1R13B(5), RACGAP1(3), RHO(1), ROCK1(5), ROCK2(3), WASF1(1), WASL(2) 17871634 128 81 127 45 28 51 8 20 21 0 0.700 1.000 1.000 290 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(3), CD3D(1), CTLA4(1), DAG1(2), DTYMK(1), EPHB2(6), FBXW7(10), GRAP2(1), ITK(2), ITPKA(1), ITPKB(6), LCK(3), LCP2(2), MAPK1(1), NCK1(2), NFAT5(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), NFKBIL2(5), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(6), PLCG1(3), PTPRC(7), RAF1(1), RASGRP1(1), RASGRP2(1), RASGRP3(8), RASGRP4(5), SOS1(11), SOS2(7), VAV1(7), ZAP70(5) 14847334 126 81 123 42 33 42 12 23 16 0 0.720 1.000 1.000 291 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(9), CCND1(1), CCND2(3), CCND3(1), CTNNB1(4), DVL1(2), DVL3(2), FOSL1(1), FZD1(1), FZD10(2), FZD2(1), FZD3(5), FZD6(3), FZD7(3), FZD8(1), FZD9(2), JUN(3), LDLR(4), MAPK10(1), MAPK9(1), MYC(1), PAFAH1B1(1), PLAU(2), PPP2R5C(6), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCI(5), PRKCQ(4), PRKCZ(1), PRKD1(11), RAC1(1), SFRP4(4), TCF7(1), WNT1(1), WNT10A(1), WNT10B(4), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT5A(1), WNT5B(1), WNT6(1), WNT7A(3), WNT7B(1) 15854150 128 80 127 40 40 55 8 18 7 0 0.356 1.000 1.000 292 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(5), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), ALDH3A1(2), ALDH3B2(1), AOC2(2), AOC3(3), AOX1(13), CARM1(1), DBH(2), DCT(4), DDC(6), ECH1(1), ESCO1(2), ESCO2(1), FAH(1), GOT2(3), GSTZ1(2), HGD(4), HPD(1), LCMT1(2), LCMT2(1), METTL2B(1), METTL6(2), MYST3(11), MYST4(4), PNMT(2), PNPLA3(1), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), SH3GLB1(1), TAT(1), TH(2), TPO(10), TYR(10), TYRP1(2), WBSCR22(3) 15738617 135 79 135 43 31 54 5 27 18 0 0.470 1.000 1.000 293 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 43 AKT1(1), AKT3(3), BRAF(8), CAB39(1), DDIT4(2), EIF4B(5), FIGF(2), HIF1A(1), IGF1(3), MAPK1(1), MAPK3(1), PDPK1(1), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PRKAA2(5), RHEB(1), RICTOR(3), RPS6(1), RPS6KA1(2), RPS6KA2(7), RPS6KA3(1), RPS6KA6(5), RPS6KB1(1), RPS6KB2(1), STK11(3), TSC1(5), TSC2(5), ULK1(4), ULK2(5), VEGFC(6) 13479302 121 79 120 31 35 40 11 13 22 0 0.229 1.000 1.000 294 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ABP1(5), ACAT1(2), ACMSD(1), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), AOC2(2), AOC3(3), AOX1(13), ASMT(1), CYP19A1(4), CYP1A1(7), CYP1A2(1), CYP2A13(1), CYP2A6(5), CYP2A7(1), CYP2B6(4), CYP2C18(2), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2D6(2), CYP2F1(3), CYP2J2(1), CYP3A4(1), CYP3A7(1), CYP4B1(3), CYP4F8(4), DDC(6), ECHS1(1), EHHADH(1), GCDH(2), HADHA(2), KMO(3), KYNU(3), SDS(2), TDO2(2), TPH1(2), WARS(4), WARS2(2) 14600619 123 79 123 51 36 41 6 31 9 0 0.909 1.000 1.000 295 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(7), ATP4A(6), ATP4B(2), ATP5A1(3), ATP5B(2), ATP5C1(3), ATP5G2(2), ATP5G3(1), ATP5L(1), ATP6V0A1(3), ATP6V0A2(6), ATP6V0A4(3), ATP6V0D1(2), ATP6V0D2(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), COX10(2), COX4I1(1), COX4I2(1), COX6B1(2), COX6C(1), COX7B2(3), CYC1(5), NDUFA10(3), NDUFA13(2), NDUFA7(1), NDUFA9(1), NDUFAB1(1), NDUFB1(1), NDUFB5(2), NDUFB6(1), NDUFB7(2), NDUFB8(2), NDUFB9(1), NDUFS1(4), NDUFS6(1), NDUFS8(1), NDUFV1(2), NDUFV2(2), PPA2(1), SDHA(2), SDHB(2), UQCRB(1), UQCRC2(1), UQCRFS1(2) 14780080 110 78 110 32 27 29 13 26 15 0 0.434 1.000 1.000 296 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(3), AGPAT3(1), AGPAT4(1), AGPAT6(1), CDS1(2), CHAT(9), CHKA(4), CHPT1(1), CRLS1(2), DGKA(3), DGKB(6), DGKD(6), DGKE(4), DGKG(3), DGKI(13), DGKQ(1), DGKZ(4), ESCO1(2), ESCO2(1), ETNK1(3), GNPAT(2), GPAM(3), GPD1(2), GPD1L(1), GPD2(2), LYPLA1(3), MYST3(11), MYST4(4), PCYT1B(2), PISD(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLD1(7), PLD2(2), PNPLA3(1), PPAP2B(1), PTDSS1(4), SH3GLB1(1) 17375860 139 78 139 55 36 55 9 22 17 0 0.907 1.000 1.000 297 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 CREBBP(17), CTBP1(2), DLL1(1), DLL3(1), DLL4(1), DTX2(3), DTX3(2), DTX3L(3), DTX4(2), DVL1(2), DVL3(2), EP300(9), HDAC1(2), JAG1(1), JAG2(2), LFNG(1), MAML1(3), MAML2(7), MFNG(1), NCOR2(7), NCSTN(3), NOTCH1(18), NOTCH2(9), NOTCH3(7), NOTCH4(4), PSEN1(3), PSEN2(3), PSENEN(1), SNW1(2) 18305930 119 78 118 49 18 44 11 26 20 0 0.959 1.000 1.000 298 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(27), B3GALT4(1), CDR1(4), DGKI(13), IL6ST(1), MRPL19(1), PIGK(1), RPL13(1), RPL14(1), RPL19(1), RPL28(1), RPL32(1), RPL37(1), RPL3L(2), RPL4(1), RPL5(2), RPL7(1), RPL7A(1), RPL8(2), RPLP0(3), RPS11(1), RPS12(1), RPS18(1), RPS19(1), RPS2(1), RPS20(1), RPS21(1), RPS26(1), RPS6(1), RPS6KA1(2), RPS6KA2(7), RPS6KA3(1), RPS6KA6(5), RPS6KB1(1), RPS6KB2(1), RPS8(2), SLC36A2(2), TBC1D10C(3), TSPAN9(1), UBB(2), UBC(1) 13868005 103 78 103 41 29 33 7 26 8 0 0.909 1.000 1.000 299 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 33 AKT1(1), AKT3(3), BRAF(8), DAG1(2), DRD2(4), EGFR(7), EPHB2(6), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(14), ITPR3(3), KCNJ5(2), KCNJ9(3), MAPK1(1), PI3(1), PIK3CB(4), PITX2(3), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), RAF1(1), RGS20(1), SHC1(2), SOS1(11), SOS2(7), STAT3(2) 15286508 123 78 121 38 31 47 5 22 18 0 0.408 1.000 1.000 300 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 39 AGL(6), AMY2B(7), ENPP1(8), ENPP3(6), G6PC(3), GANAB(5), GBE1(2), GCK(5), GPI(5), GUSB(2), GYS1(1), GYS2(4), HK1(2), HK2(5), HK3(5), MGAM(5), PGM1(1), PYGB(3), PYGL(3), PYGM(6), UCHL3(1), UGDH(2), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(3), UGT1A9(3), UGT2B15(3), UGT2B4(8), UXS1(4) 13917794 119 78 119 36 26 48 7 24 14 0 0.394 1.000 1.000 301 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(3), ACTB(1), ACTG1(2), ARHGEF2(7), CD14(2), CDC42(1), CDH1(3), CLDN1(2), CTNNB1(4), CTTN(5), FYN(5), HCLS1(3), ITGB1(5), KRT18(2), NCK1(2), NCK2(2), NCL(1), PRKCA(5), ROCK1(5), ROCK2(3), TLR4(10), TLR5(2), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3D(2), TUBA3E(5), TUBA4A(1), TUBA8(1), TUBAL3(3), TUBB(1), TUBB1(1), TUBB2A(2), TUBB3(2), TUBB4(4), TUBB4Q(2), TUBB8(1), WAS(3), WASL(2), YWHAQ(1) 13673351 110 77 109 32 31 35 10 17 17 0 0.382 1.000 1.000 302 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(3), ACTB(1), ACTG1(2), ARHGEF2(7), CD14(2), CDC42(1), CDH1(3), CLDN1(2), CTNNB1(4), CTTN(5), FYN(5), HCLS1(3), ITGB1(5), KRT18(2), NCK1(2), NCK2(2), NCL(1), PRKCA(5), ROCK1(5), ROCK2(3), TLR4(10), TLR5(2), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3D(2), TUBA3E(5), TUBA4A(1), TUBA8(1), TUBAL3(3), TUBB(1), TUBB1(1), TUBB2A(2), TUBB3(2), TUBB4(4), TUBB4Q(2), TUBB8(1), WAS(3), WASL(2), YWHAQ(1) 13673351 110 77 109 32 31 35 10 17 17 0 0.382 1.000 1.000 303 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(3), F11(3), F12(1), F13B(13), F5(18), F7(2), F8(10), F9(7), FGA(5), FGB(4), FGG(2), LPA(15), PLAT(1), PLAU(2), PLG(2), SERPINB2(4), SERPINF2(3), VWF(17) 9325627 112 76 112 25 34 41 8 18 11 0 0.102 1.000 1.000 304 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 51 ACTG1(2), APAF1(4), ARHGDIB(2), BAG4(1), BIRC2(1), BIRC3(3), CASP2(1), CASP7(2), CASP8(2), CASP9(3), CFLAR(2), CHUK(2), CRADD(1), DAXX(3), DFFB(2), FADD(1), GSN(2), MAP2K7(1), MAP3K1(3), MAP3K14(1), MAP3K5(4), MAPK8(3), MDM2(2), NFKB1(2), NUMA1(5), PAK2(1), PRKCD(2), PRKDC(12), PSEN1(3), PSEN2(3), PTK2(6), RASA1(8), RELA(3), SPTAN1(4), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF1(4) 18008180 106 76 105 37 27 33 4 20 22 0 0.776 1.000 1.000 305 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 50 ACTA1(3), AGT(1), AKT1(1), CALM2(1), CALR(1), CAMK1G(3), CAMK4(3), CREBBP(17), CSNK1A1(2), ELSPBP1(1), FGF2(2), HAND1(1), HAND2(2), HRAS(5), IGF1(3), MAP2K1(2), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(3), MEF2C(4), MYH2(33), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NKX2-5(1), PIK3R1(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), RAF1(1), RPS6KB1(1), SYT1(4) 12790245 136 76 135 47 36 56 9 21 14 0 0.729 1.000 1.000 306 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(2), ACTG2(6), AKT1(1), CDC42(1), CFL1(2), CFL2(1), FLNA(14), FLNC(16), FSCN2(1), FSCN3(2), GDI1(2), GDI2(2), MYH2(33), MYLK(8), MYLK2(4), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(6), PFN2(1), RHO(1), ROCK1(5), ROCK2(3), VASP(2), WASF1(1), WASL(2) 12714411 122 76 122 45 29 54 7 19 13 0 0.727 1.000 1.000 307 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(4), ATP6V0A1(3), ATP6V0A2(6), ATP6V0A4(3), ATP6V0D1(2), ATP6V0D2(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), CDC42(1), CHUK(2), EGFR(7), F11R(1), GIT1(1), HBEGF(1), IGSF5(2), IKBKB(2), JAM2(2), JUN(3), LYN(2), MAP2K4(1), MAP3K14(1), MAPK10(1), MAPK11(2), MAPK13(2), MAPK14(1), MAPK8(3), MAPK9(1), MET(4), NFKB1(2), NFKB2(2), NOD1(4), PAK1(2), PLCG1(3), PLCG2(5), PTPN11(3), PTPRZ1(9), RAC1(1), RELA(3), TJP1(9) 18621548 119 75 117 33 31 35 7 23 23 0 0.333 1.000 1.000 308 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 IMPA1(2), INPP1(1), INPP4A(4), INPP4B(6), INPP5A(4), INPPL1(4), ITPKA(1), ITPKB(6), MIOX(1), OCRL(8), PIK3C2A(7), PIK3C2B(7), PIK3C2G(8), PIK3CB(4), PIK3CG(19), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PLCD1(1), PLCG1(3), PLCG2(5) 11367686 115 75 115 36 31 42 8 16 18 0 0.474 1.000 1.000 309 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 30 AKT1(1), AKT3(3), BCR(2), BTK(7), CD19(2), FLOT1(1), FLOT2(1), GAB1(3), ITPR1(6), ITPR2(14), ITPR3(3), LYN(2), NR0B2(1), PDK1(1), PHF11(2), PITX2(3), PLCG2(5), PPP1R13B(5), PREX1(14), PTPRC(7), RPS6KA1(2), RPS6KA2(7), RPS6KA3(1), RPS6KB1(1), SYK(1), TEC(4), VAV1(7) 13757246 106 75 105 41 33 36 6 17 14 0 0.860 1.000 1.000 310 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 38 AKT1(1), AKT3(3), BCR(2), BLNK(1), BTK(7), CD19(2), DAG1(2), EPHB2(6), ITPKA(1), ITPKB(6), LYN(2), MAP2K1(2), MAP2K2(1), MAPK1(1), NFAT5(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), NFKBIL2(5), PI3(1), PIK3CD(4), PIK3R1(2), PLCG2(5), PPP1R13B(5), RAF1(1), SERPINA4(7), SHC1(2), SOS1(11), SOS2(7), SYK(1), VAV1(7) 13385539 106 75 106 41 29 37 7 19 14 0 0.873 1.000 1.000 311 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 ALG2(3), BAK1(1), BAX(1), BTK(7), CAD(11), CASP10(3), CASP8(2), CASP8AP2(6), CD7(1), CDK2AP1(1), CSNK1A1(2), DAXX(3), EGFR(7), EPHB2(6), FADD(1), FAF1(1), FAIM2(1), IL1A(1), MAP2K4(1), MAP2K7(1), MAP3K1(3), MAP3K5(4), MAPK1(1), MAPK10(1), MAPK8(3), MAPK8IP1(2), MAPK8IP3(4), MAPK9(1), MET(4), NFAT5(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), NFKBIL2(5), NR0B2(1), PFN2(1), PTPN13(9), RALBP1(1), ROCK1(5), SMPD1(4), TNFRSF6B(1), TPX2(1), TUFM(1) 19197713 123 75 122 39 32 43 8 23 17 0 0.656 1.000 1.000 312 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(2), AARS2(5), CARS(8), CARS2(1), DARS(1), DARS2(5), EARS2(3), EPRS(12), FARS2(2), FARSA(5), HARS(2), HARS2(2), IARS(3), IARS2(3), KARS(3), LARS(1), LARS2(3), MARS(1), NARS(4), NARS2(2), PARS2(4), RARS(4), RARS2(2), SARS(2), SARS2(3), TARS(3), TARS2(4), VARS(5), VARS2(2), WARS(4), WARS2(2), YARS(1), YARS2(2) 14365230 106 74 106 27 40 33 5 16 12 0 0.189 1.000 1.000 313 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 44 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH7(1), ADHFE1(2), AGPAT3(1), AGPAT4(1), AKR1B1(1), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), CEL(1), DGAT1(1), DGKA(3), DGKB(6), DGKD(6), DGKE(4), DGKG(3), DGKQ(1), DGKZ(4), GK(4), GLA(2), LCT(18), LIPC(2), LIPF(1), LIPG(3), LPL(3), PNLIPRP1(4), PNLIPRP2(4), PPAP2B(1) 12520961 95 73 95 44 25 45 3 15 7 0 0.951 1.000 1.000 314 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 30 ABAT(4), ADC(1), ALDH4A1(3), ALDH5A1(1), CAD(11), EARS2(3), EPRS(12), GAD1(5), GAD2(6), GCLC(2), GCLM(1), GFPT1(1), GFPT2(4), GLS(4), GLS2(1), GLUD1(4), GLUD2(9), GLUL(4), GOT2(3), GPT(1), GPT2(4), GSR(4), GSS(2), NADSYN1(7), NAGK(2), PPAT(2) 9661593 101 73 101 28 26 43 5 18 9 0 0.273 1.000 1.000 315 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 47 ACCN1(6), ADCY4(4), ADCY6(2), ADCY8(18), CACNA1A(11), CACNA1B(10), GNAS(6), GNAT3(1), GNB1(1), GNB3(2), GRM4(3), ITPR3(3), KCNB1(1), PDE1A(2), PLCB2(5), PRKACB(3), PRKACG(1), PRKX(1), SCNN1A(1), SCNN1B(1), SCNN1G(3), TAS1R1(3), TAS1R3(3), TAS2R1(4), TAS2R10(3), TAS2R16(4), TAS2R3(2), TAS2R38(2), TAS2R39(2), TAS2R4(1), TAS2R40(3), TAS2R41(5), TAS2R42(2), TAS2R5(1), TAS2R7(1), TAS2R8(1), TAS2R9(3), TRPM5(1) 14916004 126 73 126 53 35 43 8 29 11 0 0.874 1.000 1.000 316 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH7(1), ADHFE1(2), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3B2(1), ALDH9A1(2), ALDOA(1), ALDOB(2), BPGM(1), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(3), GAPDH(2), GCK(5), GPI(5), HK1(2), HK2(5), HK3(5), LDHB(3), LDHC(3), PDHA1(3), PDHA2(8), PFKM(6), PFKP(2), PGK1(2), PGM1(1), PKLR(4), PKM2(3), TPI1(3) 12914807 97 72 97 36 26 40 5 17 9 0 0.686 1.000 1.000 317 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH7(1), ADHFE1(2), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3B2(1), ALDH9A1(2), ALDOA(1), ALDOB(2), BPGM(1), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(3), GAPDH(2), GCK(5), GPI(5), HK1(2), HK2(5), HK3(5), LDHB(3), LDHC(3), PDHA1(3), PDHA2(8), PFKM(6), PFKP(2), PGK1(2), PGM1(1), PKLR(4), PKM2(3), TPI1(3) 12914807 97 72 97 36 26 40 5 17 9 0 0.686 1.000 1.000 318 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(3), AGPAT3(1), AGPAT4(1), AGPS(1), CDS1(2), CHAT(9), CHKA(4), CPT1B(3), DGKA(3), DGKB(6), DGKD(6), DGKE(4), DGKG(3), DGKQ(1), DGKZ(4), ETNK1(3), GNPAT(2), GPD1(2), GPD2(2), LGALS13(1), LYPLA1(3), PAFAH1B1(1), PCYT1B(2), PISD(1), PLA2G2A(1), PLA2G2E(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLCB2(5), PLCG1(3), PLCG2(5), PPAP2B(1) 13242836 102 71 102 37 29 40 9 15 9 0 0.677 1.000 1.000 319 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(1), AASDHPPT(1), AASS(11), ACAT1(2), AKR1B10(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), BBOX1(2), DLST(1), DOT1L(5), ECHS1(1), EHHADH(1), EHMT1(5), EHMT2(1), GCDH(2), HADH(1), HADHA(2), HSD17B4(1), NSD1(10), OGDH(3), OGDHL(6), PIPOX(1), PLOD1(4), PLOD2(5), PLOD3(5), RDH11(1), RDH12(2), RDH13(1), SETD1A(8), SETDB1(3), SPCS1(1), SPCS3(2), SUV39H1(2), SUV39H2(2), TMLHE(1) 15332602 105 71 105 43 20 36 7 24 18 0 0.921 1.000 1.000 320 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 48 ACOX1(2), APOA2(1), CD36(1), CITED2(1), CPT1B(3), CREBBP(17), EHHADH(1), EP300(9), FABP1(1), HSD17B4(1), JUN(3), LPL(3), MAPK1(1), MAPK3(1), ME1(2), MRPL11(1), MYC(1), NCOA1(6), NCOR1(8), NCOR2(7), NR0B2(1), NR1H3(2), NRIP1(3), PIK3R1(2), PPARA(1), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCA(5), PTGS2(1), RELA(3), RXRA(2), SP1(2), STAT5A(2), TNF(1) 15680653 106 71 104 45 29 38 5 21 13 0 0.961 1.000 1.000 321 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 32 AKT1(1), APC(9), AR(5), BRAF(8), CCL16(1), DAG1(2), EGFR(7), GNA11(1), GNAI1(3), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(14), ITPR3(3), KCNJ5(2), KCNJ9(3), MAPK1(1), MAPK10(1), MAPK14(1), PHKA2(4), PIK3CD(4), PIK3R1(2), PITX2(3), PTX3(2), RAF1(1) 13304634 91 71 89 26 24 36 5 16 10 0 0.290 1.000 1.000 322 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(2), AARS2(5), ABAT(4), ACY3(2), ADSL(1), ADSS(1), ADSSL1(2), AGXT(2), AGXT2(2), ASL(4), ASNS(5), CAD(11), DARS(1), DARS2(5), DDO(2), DLAT(1), DLD(2), GAD1(5), GAD2(6), GOT2(3), GPT(1), GPT2(4), NARS(4), NARS2(2), PC(2), PDHA1(3), PDHA2(8) 10035740 90 69 90 31 25 30 5 19 11 0 0.629 1.000 1.000 323 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(2), CALR(1), CANX(2), CD4(1), CD8A(2), CD8B(1), CIITA(3), CREB1(1), CTSL1(3), CTSS(2), HLA-A(6), HLA-B(1), HLA-C(1), HLA-DMA(1), HLA-DMB(1), HLA-DOA(1), HLA-DOB(1), HLA-DPA1(2), HLA-DQA2(1), HLA-DRA(1), HLA-DRB1(2), HLA-DRB5(2), HLA-G(2), HSP90AA1(3), HSP90AB1(3), HSPA5(4), IFNA1(1), IFNA10(3), IFNA14(2), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA7(1), IFNA8(2), KIR2DL1(2), KIR2DL3(4), KIR2DL4(1), KIR2DS4(3), KIR3DL1(6), KIR3DL2(1), KIR3DL3(1), KLRC1(1), KLRC3(2), KLRD1(1), LTA(2), NFYA(1), NFYB(1), PDIA3(2), PSME2(1), TAP1(3), TAP2(1), TAPBP(4) 12292651 101 69 100 43 30 30 8 16 16 1 0.913 1.000 1.000 324 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 41 CALM2(1), CD3D(1), FOS(2), FYN(5), HRAS(5), JUN(3), LCK(3), MAP2K1(2), MAP2K4(1), MAP3K1(3), MAPK3(1), MAPK8(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NFKB1(2), PIK3R1(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(5), PTPN7(1), RAC1(1), RAF1(1), RASA1(8), RELA(3), SHC1(2), SOS1(11), SYT1(4), VAV1(7), ZAP70(5) 12042074 110 69 108 24 34 36 9 17 14 0 0.0925 1.000 1.000 325 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(1), B4GALT5(2), C1GALT1C1(1), GALNT1(2), GALNT10(3), GALNT11(2), GALNT12(3), GALNT13(14), GALNT14(4), GALNT2(2), GALNT3(3), GALNT5(7), GALNT6(2), GALNT8(3), GALNT9(1), GALNTL1(4), GALNTL4(4), GALNTL5(3), GCNT1(3), GCNT3(2), OGT(2), ST3GAL1(4), ST6GALNAC1(3), WBSCR17(12) 8546433 87 67 85 29 20 34 10 14 9 0 0.664 1.000 1.000 326 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 41 AKT1(1), BRAF(8), CREB1(1), CREB3(2), CREB5(3), CREBBP(17), CRKL(1), DAG1(2), EGR1(2), EGR2(6), EGR3(2), FRS2(4), JUN(3), MAP1B(4), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(3), MAPK8IP1(2), MAPK8IP3(4), MAPK9(1), NTRK1(4), OPN1LW(3), PIK3C2G(8), PIK3CD(4), PIK3R1(2), PTPN11(3), RPS6KA3(1), SHC1(2), TH(2) 13046655 100 67 99 42 29 41 7 13 10 0 0.926 1.000 1.000 327 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 22 ADRB1(1), AKT1(1), APC(9), CAV3(1), DAG1(2), DLG4(1), EPHB2(6), GNAI1(3), ITPR1(6), ITPR2(14), ITPR3(3), KCNJ5(2), KCNJ9(3), MAPK1(1), PITX2(3), PTX3(2), RAC1(1), RHO(1), RYR1(28) 11936092 88 67 87 28 18 35 5 17 13 0 0.366 1.000 1.000 328 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 36 BTK(7), CALM2(1), FCER1A(4), FCER1G(1), FOS(2), HRAS(5), JUN(3), LYN(2), MAP2K1(2), MAP2K4(1), MAP2K7(1), MAP3K1(3), MAPK1(1), MAPK3(1), MAPK8(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), PAK2(1), PIK3R1(2), PLA2G4A(7), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), RAF1(1), SHC1(2), SOS1(11), SYK(1), SYT1(4), VAV1(7) 10779764 101 66 99 34 33 39 8 11 10 0 0.757 1.000 1.000 329 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(2), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(3), GAPDH(2), GAPDHS(1), GCK(5), GOT2(3), GPI(5), HK1(2), HK2(5), HK3(5), LDHAL6B(1), LDHB(3), LDHC(3), MDH1(1), MDH2(1), PC(2), PCK1(3), PDHA1(3), PDHA2(8), PDHX(1), PFKL(2), PFKM(6), PFKP(2), PGAM2(1), PGK1(2), PGK2(4), PKLR(4), PKM2(3), TPI1(3) 11216771 93 66 93 42 24 35 5 18 11 0 0.924 1.000 1.000 330 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 CHUK(2), DAXX(3), EGF(6), EGFR(7), ETS1(2), FOS(2), HOXA7(2), HRAS(5), IKBKB(2), JUN(3), MAP2K1(2), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP2K7(1), MAP3K1(3), MAP3K14(1), MAP3K5(4), MAPK1(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(3), NFKB1(2), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCQ(4), RAF1(1), RELA(3), SP1(2), TNF(1), TNFRSF1A(2), TNFRSF1B(1) 13005875 94 66 91 29 28 37 6 13 10 0 0.450 1.000 1.000 331 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 33 ACTA1(3), CRKL(1), DOCK1(4), FOS(2), GAB1(3), HGF(10), HRAS(5), ITGA1(4), ITGB1(5), JUN(3), MAP2K1(2), MAP2K2(1), MAP4K1(3), MAPK1(1), MAPK3(1), MAPK8(3), MET(4), PAK1(2), PIK3R1(2), PTK2(6), PTPN11(3), PXN(3), RAF1(1), RAP1A(1), RAP1B(1), RASA1(8), SOS1(11), STAT3(2) 10942016 95 66 93 37 30 27 4 17 17 0 0.950 1.000 1.000 332 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 42 ABP1(5), AGMAT(1), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH4A1(3), ALDH9A1(2), AMD1(1), AOC2(2), AOC3(3), ARG1(2), ASL(4), CKM(2), CKMT2(3), DAO(2), GATM(1), GLUD1(4), GOT2(3), NOS1(11), NOS3(2), OAT(1), ODC1(1), OTC(3), P4HA1(2), P4HA2(3), P4HA3(3), P4HB(5), PYCR1(1), RARS(4), SMS(2) 10864838 86 65 86 29 18 32 3 18 15 0 0.566 1.000 1.000 333 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(11), GABBR1(5), GPRC5A(1), GPRC5C(4), GRM1(13), GRM2(3), GRM3(14), GRM4(3), GRM5(12), GRM7(10), GRM8(14) 5532457 90 65 90 38 17 36 15 14 8 0 0.809 1.000 1.000 334 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 BLVRA(2), COX10(2), CP(2), CPOX(2), EARS2(3), EPRS(12), FECH(2), FTH1(2), FTMT(7), GUSB(2), HCCS(1), MMAB(1), PPOX(1), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(3), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(4), UGT2B11(5), UGT2B15(3), UGT2B28(5), UGT2B4(8), UGT2B7(2), UROD(1), UROS(1) 10906565 94 65 94 25 26 34 9 17 8 0 0.319 1.000 1.000 335 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(2), ADRA1B(3), ADRA1D(3), ADRA2C(2), ADRB1(1), ADRB2(4), CHRM2(9), CHRM3(5), CHRM4(1), CHRM5(3), DRD1(1), DRD2(4), DRD3(5), DRD4(1), DRD5(3), HRH1(3), HRH2(2), HTR1A(8), HTR1B(3), HTR1E(5), HTR1F(3), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(3), HTR5A(4), HTR6(2), HTR7(4) 6774899 93 64 93 38 21 39 7 18 8 0 0.458 1.000 1.000 336 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(1), AKT3(3), ARHGEF11(6), CDC42(1), DLG4(1), GNA13(1), LPA(15), MAP2K4(1), MAP3K1(3), MAP3K5(4), MAPK8(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), NFKBIL2(5), PDK1(1), PHKA2(4), PI3(1), PIK3CB(4), PLD1(7), PLD2(2), PLD3(1), PTK2(6), RDX(2), ROCK1(5), ROCK2(3), SERPINA4(7), SRF(2), TBXA2R(2) 13006015 99 64 99 38 25 35 4 25 10 0 0.890 1.000 1.000 337 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(4), BAX(1), BCL2A1(2), BCL2L1(1), CASP1(1), CASP10(3), CASP2(1), CASP4(4), CASP7(2), CASP8(2), CASP9(3), CD40(2), CD40LG(3), CRADD(1), DAXX(3), DFFB(2), FADD(1), FAS(1), FASLG(1), IKBKE(3), LTA(2), MCL1(2), NFKB1(2), NGFR(1), NR3C1(1), NTRK1(4), PTPN13(9), SFRS2IP(4), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF1(4), TRAF3(3), TRAF6(5) 11604373 83 63 82 37 26 16 5 18 18 0 0.986 1.000 1.000 338 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(1), AGTR1(5), ATF2(3), CALM2(1), EGFR(7), HRAS(5), JUN(3), MAP2K1(2), MAP2K2(1), MAP2K4(1), MAP3K1(3), MAPK1(1), MAPK3(1), MAPK8(3), MEF2A(2), MEF2C(4), MEF2D(3), PAK1(2), PRKCA(5), PTK2(6), RAC1(1), RAF1(1), SHC1(2), SOS1(11), SYT1(4) 8876494 78 63 75 22 22 29 5 17 5 0 0.433 1.000 1.000 339 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 19 ADCYAP1R1(9), CALCR(10), CALCRL(4), CRHR1(4), CRHR2(3), EMR1(11), EMR2(4), GHRHR(4), GLP1R(1), GLP2R(5), GPR64(5), LPHN1(3), LPHN2(7), LPHN3(17), SCTR(1), VIPR2(3) 6691349 91 63 91 27 29 30 8 18 6 0 0.264 1.000 1.000 340 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(2), ARSD(1), ARSE(2), B4GALT6(2), CERK(6), DEGS1(1), ENPP7(4), GAL3ST1(1), GALC(2), GBA(4), GLA(2), LCT(18), NEU1(3), NEU2(2), NEU4(2), PPAP2B(1), SGMS1(3), SGMS2(1), SGPP1(2), SMPD1(4), SMPD2(1), SMPD3(3), SMPD4(8), SPHK2(1), SPTLC1(1), SPTLC2(3), UGCG(1), UGT8(7) 9449717 88 63 88 28 17 32 7 22 10 0 0.414 1.000 1.000 341 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(3), ACTN1(2), ACTN2(10), ACTN3(2), BCAR1(6), BCR(2), CAPN1(2), CAPNS2(1), CRKL(1), FYN(5), HRAS(5), ITGA1(4), ITGB1(5), JUN(3), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(3), PPP1R12B(5), PTK2(6), PXN(3), RAF1(1), RAP1A(1), ROCK1(5), SHC1(2), SOS1(11), TLN1(6), VCL(2), ZYX(1) 12459260 102 63 100 32 29 36 5 23 9 0 0.539 1.000 1.000 342 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(11), CANT1(1), CDA(1), CTPS(3), CTPS2(2), DCK(1), DCTD(1), DPYD(9), DPYS(6), DTYMK(1), ENTPD1(1), NT5E(2), POLB(1), POLD1(2), POLD2(1), POLE(7), POLG(2), POLL(2), POLQ(19), POLR1B(2), POLR2A(2), POLR2B(6), POLR2D(1), POLR2E(2), POLRMT(2), RRM1(1), RRM2(1), TXNRD1(2), UMPS(2), UPP1(3) 15194434 97 63 97 25 27 39 3 15 13 0 0.205 1.000 1.000 343 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 46 AKT1(1), AKT3(3), BRD4(3), CAP1(2), CBL(3), CDC42(1), F2RL2(1), FLOT1(1), FLOT2(1), GSK3A(3), INPPL1(4), IRS1(7), IRS2(1), IRS4(3), LNPEP(2), MAPK1(1), MAPK3(1), PARD3(7), PARD6A(1), PDK1(1), PIK3CD(4), PIK3R1(2), PPYR1(4), PTPN1(1), RAF1(1), RPS6KA1(2), RPS6KA2(7), RPS6KA3(1), RPS6KB1(1), SERPINB6(4), SFN(2), SHC1(2), SLC2A4(2), SORBS1(5), SOS1(11), SOS2(7), YWHAB(1), YWHAQ(1) 14763154 105 63 105 35 36 34 5 18 12 0 0.672 1.000 1.000 344 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(1), BTK(7), CALM2(1), CD79A(1), FOS(2), HRAS(5), JUN(3), LYN(2), MAP2K1(2), MAP3K1(3), MAPK14(1), MAPK3(1), MAPK8(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(5), RAC1(1), RAF1(1), SHC1(2), SOS1(11), SYK(1), SYT1(4), VAV1(7) 10091050 92 62 90 24 29 35 8 11 9 0 0.313 1.000 1.000 345 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(1), AGTR2(3), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CDK5(1), FYN(5), GNA11(1), GNAI1(3), GNB1(1), HRAS(5), JAK2(4), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(3), MAPT(4), MYLK(8), PLCG1(3), PRKCA(5), RAF1(1), SHC1(2), SOS1(11), STAT1(2), STAT3(2), STAT5A(2), SYT1(4) 11027890 81 62 80 22 20 28 10 16 7 0 0.367 1.000 1.000 346 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 33 ALDH4A1(3), ARG1(2), ASL(4), CKM(2), CKMT2(3), DAO(2), EPRS(12), GATM(1), GLUD1(4), GLUD2(9), GOT2(3), LAP3(1), NOS1(11), NOS3(2), OAT(1), OTC(3), P4HA1(2), P4HA2(3), P4HA3(3), PARS2(4), PRODH(1), PYCR1(1), RARS(4), RARS2(2) 8678808 83 62 83 20 23 30 3 12 15 0 0.153 1.000 1.000 347 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(5), ACY3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3B2(1), ALDH7A1(1), ALDH9A1(2), AMDHD1(1), AOC2(2), AOC3(3), CARM1(1), CNDP1(3), DDC(6), FTCD(3), HAL(2), HARS(2), HARS2(2), HDC(6), HNMT(3), LCMT1(2), LCMT2(1), METTL2B(1), METTL6(2), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), PRPS1(2), PRPS2(1), UROC1(3), WBSCR22(3) 10476733 84 62 84 37 13 38 6 16 11 0 0.885 1.000 1.000 348 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(1), GTF2B(2), GTF2E1(2), GTF2F1(1), GTF2H1(2), GTF2H3(1), GTF2H4(2), GTF2I(2), GTF2IRD1(6), TAF1(15), TAF1L(21), TAF2(10), TAF4(3), TAF4B(4), TAF5(1), TAF5L(2), TAF6L(2), TAF7L(2), TAF9(2), TBPL2(1) 9561342 82 62 82 20 21 30 9 12 10 0 0.320 1.000 1.000 349 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(4), AR(5), ESR1(6), ESR2(2), HNF4A(2), NR0B1(4), NR1D2(1), NR1H2(1), NR1H3(2), NR1I2(1), NR1I3(1), NR2C2(3), NR2E1(4), NR2F6(1), NR3C1(1), NR4A1(3), NR4A2(3), NR5A2(5), PGR(4), PPARA(1), PPARD(2), RARA(1), RARB(3), RARG(1), ROR1(3), RORA(2), RORC(2), RXRA(2), RXRG(7), THRA(1), THRB(2), VDR(4) 11103406 84 62 84 34 21 35 2 14 12 0 0.808 1.000 1.000 350 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(12), CARM1(1), CCND1(1), CREBBP(17), EP300(9), ERCC3(1), ESR1(6), GRIP1(6), GTF2A1(1), GTF2E1(2), GTF2F1(1), HDAC1(2), HDAC3(1), HDAC4(5), HDAC5(1), MEF2C(4), NCOR2(7), NR0B1(4), NRIP1(3), PELP1(1), POLR2A(2) 12164786 87 61 86 30 19 34 4 20 10 0 0.716 1.000 1.000 351 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(6), CDC7(3), DIAPH2(4), GMNN(2), MCM10(4), MCM2(1), MCM3(1), MCM4(5), MCM5(6), MCM6(3), MCM7(3), ORC1L(3), ORC2L(1), ORC3L(2), ORC5L(3), POLD1(2), POLD2(1), POLD3(1), POLE(7), POLE2(2), PRIM1(3), RFC1(1), RFC4(5), RFC5(1), RPA1(1), RPA2(1), RPA4(2), UBB(2), UBC(1) 13479647 77 61 77 27 26 19 1 19 12 0 0.751 1.000 1.000 352 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(1), AKR1B10(2), B4GALT1(1), G6PC(3), G6PC2(3), GALK2(1), GALT(1), GANC(4), GCK(5), GLA(2), HK1(2), HK2(5), HK3(5), LCT(18), MGAM(5), PFKL(2), PFKM(6), PFKP(2), PGM1(1), RDH11(1), RDH12(2), RDH13(1), UGP2(4) 10247970 77 61 77 30 20 25 4 18 10 0 0.721 1.000 1.000 353 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(2), ACTG2(6), ADCY3(7), ADCY9(3), ARF1(1), ARF5(4), ATP6V0A1(3), ATP6V0A2(6), ATP6V0A4(3), ATP6V0D1(2), ATP6V0D2(2), ATP6V1A(4), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), ERO1L(1), GNAS(6), PDIA4(4), PLCG1(3), PLCG2(5), PRKCA(5), SEC61A1(2), SEC61A2(1), SEC61G(2), TRIM23(3) 9798214 83 61 83 24 23 30 7 15 8 0 0.381 1.000 1.000 354 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM2(1), DLG4(1), GRIN1(1), GRIN2A(16), GRIN2B(18), GRIN2C(3), GRIN2D(4), NOS1(11), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCA(5), SYT1(4) 6750568 85 61 84 31 23 31 7 13 11 0 0.675 1.000 1.000 355 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(1), ATF2(3), CDC42(1), DLD(2), DUSP10(5), DUSP4(2), DUSP8(1), GAB1(3), GADD45A(1), GCK(5), IL1R1(1), JUN(3), MAP2K4(1), MAP2K5(1), MAP2K7(1), MAP3K1(3), MAP3K11(2), MAP3K12(4), MAP3K13(5), MAP3K3(1), MAP3K4(4), MAP3K5(4), MAP3K7(2), MAP3K9(3), MAPK10(1), MAPK7(1), MAPK8(3), MAPK9(1), MYEF2(4), NFATC3(6), NR2C2(3), PAPPA(7), SHC1(2), TRAF6(5) 13100530 92 61 91 30 38 37 3 11 3 0 0.685 1.000 1.000 356 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(2), EGF(6), EGFR(7), FOS(2), HRAS(5), JAK1(2), JUN(3), MAP2K1(2), MAP2K4(1), MAP3K1(3), MAPK3(1), MAPK8(3), PIK3R1(2), PLCG1(3), PRKCA(5), RAF1(1), RASA1(8), SHC1(2), SOS1(11), SRF(2), STAT1(2), STAT3(2), STAT5A(2) 9333869 77 60 74 15 25 24 4 11 13 0 0.0866 1.000 1.000 357 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 23 ABAT(4), ALDH4A1(3), ALDH5A1(1), CAD(11), EPRS(12), GAD1(5), GAD2(6), GCLC(2), GCLM(1), GFPT1(1), GLS(4), GLS2(1), GLUD1(4), GLUL(4), GOT2(3), GPT(1), GPT2(4), GSS(2), NADSYN1(7), PPAT(2) 7992847 78 60 78 22 18 33 4 17 6 0 0.382 1.000 1.000 358 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(2), ACACB(9), ACAT1(2), ACOT12(1), ACSS1(3), AKR1B1(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), DLAT(1), DLD(2), GRHPR(2), HAGHL(1), LDHAL6A(2), LDHAL6B(1), LDHB(3), LDHC(3), LDHD(6), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(2), PC(2), PCK1(3), PCK2(1), PDHA1(3), PDHA2(8), PKLR(4), PKM2(3) 12352756 81 60 81 41 23 29 4 16 9 0 0.989 1.000 1.000 359 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 31 AKT1(1), DAG1(2), DGKA(3), ETFA(3), GCA(2), ITGA9(2), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(14), ITPR3(3), MAP2K1(2), MAPK1(1), MAPK3(1), NR1I3(1), PAK1(2), PDE3A(8), PDE3B(5), PI3(1), PIK3C2G(8), PIK3CD(4), PIK3R1(2), RIPK3(1), SGCB(3), VASP(2) 12385362 84 60 83 34 24 33 4 11 11 1 0.830 1.000 1.000 360 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 B3GALT1(3), B3GALT2(3), B3GALT4(1), B3GNT2(1), B3GNT3(4), B3GNT4(1), B4GALT1(1), B4GALT3(3), B4GALT4(3), B4GALT6(2), FUT2(1), FUT3(3), FUT5(4), FUT6(2), FUT9(5), GBGT1(2), GCNT2(2), PIGB(1), PIGF(1), PIGG(4), PIGH(1), PIGK(1), PIGL(2), PIGN(1), PIGO(2), PIGQ(1), PIGT(1), PIGX(1), PIGZ(2), ST3GAL1(4), ST3GAL4(2), ST3GAL5(2), ST3GAL6(2), ST6GALNAC3(5), ST6GALNAC4(1), ST6GALNAC5(3), ST8SIA1(3), UGCG(1) 12869860 82 59 82 37 21 31 9 12 9 0 0.892 1.000 1.000 361 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(7), ADRBK2(2), CALM2(1), CALML6(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CLCA1(7), CLCA2(5), CLCA4(3), CNGA3(6), CNGA4(5), CNGB1(4), GNAL(1), GUCA1A(2), GUCA1C(1), PDE1C(13), PRKACB(3), PRKACG(1), PRKG1(6), PRKG2(4), PRKX(1) 8085363 76 59 76 19 17 36 5 8 10 0 0.155 1.000 1.000 362 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(8), BMPR1B(1), CCND2(3), DAZL(1), DMC1(1), EGR1(2), ESR2(2), FSHR(15), GJA4(1), INHA(3), LHCGR(9), MLH1(2), MSH5(3), NCOR1(8), NRIP1(3), PGR(4), PRLR(6), PTGER2(2), SMPD1(4), VDR(4), ZP2(2) 9271043 84 59 84 33 25 28 4 14 13 0 0.923 1.000 1.000 363 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(5), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH7(1), ADHFE1(2), ALDH3A1(2), ALDH3B2(1), AOC2(2), AOC3(3), AOX1(13), DBH(2), DCT(4), DDC(6), FAH(1), GOT2(3), GSTZ1(2), HGD(4), HPD(1), PNMT(2), TAT(1), TH(2), TPO(10), TYR(10) 8388822 83 59 83 28 17 38 3 19 6 0 0.481 1.000 1.000 364 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 APAF1(4), BAK1(1), BAX(1), BCL2L1(1), BIRC2(1), BIRC3(3), CASP1(1), CASP10(3), CASP2(1), CASP4(4), CASP7(2), CASP8(2), CASP9(3), CHUK(2), DFFB(2), FADD(1), FAS(1), FASLG(1), GZMB(1), IKBKB(2), IRF1(1), IRF3(1), IRF4(2), IRF6(6), JUN(3), LTA(2), MAP2K4(1), MAP3K1(3), MAPK10(1), MDM2(2), MYC(1), NFKB1(2), NFKBIB(1), NFKBIE(1), PRF1(1), RELA(3), TNF(1), TNFRSF10B(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(3), TRADD(1), TRAF1(4), TRAF3(3) 14962579 84 58 82 35 24 20 6 16 18 0 0.951 1.000 1.000 365 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(7), GNAS(6), GNB1(1), HRAS(5), IGF1R(1), ITGB1(5), KLK2(2), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MKNK2(1), MYC(1), NGFR(1), PDGFRA(10), PTPRR(9), RAF1(1), RPS6KA1(2), RPS6KA5(4), SHC1(2), SOS1(11), STAT3(2) 8747044 76 58 74 22 18 32 6 16 4 0 0.423 1.000 1.000 366 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM2(1), CAMK1G(3), FPR1(1), GNB1(1), HRAS(5), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K6(2), MAP3K1(3), MAPK1(1), MAPK14(1), MAPK3(1), NCF2(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NFKB1(2), PAK1(2), PIK3C2G(8), PLCB1(8), PPP3CA(4), PPP3CB(4), PPP3CC(2), RAC1(1), RAF1(1), RELA(3), SYT1(4) 10152689 82 58 81 38 20 36 6 14 6 0 0.977 1.000 1.000 367 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(1), AADAC(3), ABAT(4), ACADS(2), ACAT1(2), ACSM1(5), AKR1B10(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH5A1(1), ALDH7A1(1), ALDH9A1(2), BDH1(4), DDHD1(5), ECHS1(1), EHHADH(1), GAD1(5), GAD2(6), HADH(1), HADHA(2), HMGCL(1), HMGCS1(1), HMGCS2(3), HSD17B4(1), ILVBL(2), OXCT1(3), PDHA1(3), PDHA2(8), PLA1A(6), PRDX6(2), RDH11(1), RDH12(2), RDH13(1) 10754671 88 58 88 36 26 33 2 19 8 0 0.888 1.000 1.000 368 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(1), ALPL(3), ALPP(3), ALPPL2(1), ASCC3(10), ATP13A2(1), DDX18(2), DDX19A(1), DDX23(3), DDX4(2), DDX41(2), DDX50(1), DDX51(1), DDX52(1), DDX54(3), DDX55(1), DDX56(1), ENTPD7(2), EP400(9), ERCC3(1), FPGS(2), GCH1(2), GGH(2), IFIH1(4), MOV10L1(7), NUDT8(1), RAD54L(1), SETX(12), SKIV2L2(2), SMARCA2(4) 16616228 86 58 86 41 26 31 9 11 9 0 0.988 1.000 1.000 369 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(3), ARSB(2), FUCA1(2), FUCA2(1), GALNS(3), GBA(4), GNS(1), GUSB(2), HEXA(5), HGSNAT(1), HPSE(3), HPSE2(2), HYAL1(3), IDS(1), IDUA(2), LCT(18), MAN2B1(2), MAN2B2(3), MAN2C1(6), MANBA(2), NEU1(3), NEU2(2), NEU4(2), SPAM1(7) 9102561 80 58 80 25 19 24 6 23 8 0 0.460 1.000 1.000 370 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(3), CAPN1(2), CAPN2(2), CAPNS2(1), CXCR3(1), EGF(6), EGFR(7), HRAS(5), ITGA1(4), ITGB1(5), MAPK1(1), MAPK3(1), MYL2(2), MYLK(8), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PTK2(6), PXN(3), TLN1(6) 8657950 74 58 72 22 19 27 6 14 8 0 0.462 1.000 1.000 371 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT1(1), AKT3(3), IARS(3), IL13RA1(2), IL2RG(1), IL4(2), IL4R(2), INPP5D(8), JAK1(2), JAK2(4), JAK3(7), NR0B2(1), PI3(1), PPP1R13B(5), RPS6KB1(1), SERPINA4(7), SHC1(2), SOS1(11), SOS2(7), STAT6(2), TYK2(8) 9198562 80 58 80 21 22 25 4 16 13 0 0.281 1.000 1.000 372 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(1), AKT3(3), ANKRD6(1), APC(9), AXIN2(2), CER1(2), CSNK1A1(2), CTNNB1(4), DACT1(5), DKK1(4), DKK2(1), DKK4(1), DVL1(2), FSTL1(2), GSK3A(3), LRP1(15), MVP(2), NKD1(2), NKD2(2), PSEN1(3), SENP2(3), WIF1(6) 10726362 75 58 75 27 13 35 4 13 9 1 0.702 1.000 1.000 373 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(4), ACAA1(1), ACAA2(1), ACADM(1), ACADS(2), ACAT1(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH6A1(1), ALDH7A1(1), ALDH9A1(2), AOX1(13), AUH(1), BCAT1(1), BCAT2(2), BCKDHB(2), DBT(1), DLD(2), ECHS1(1), EHHADH(1), HADH(1), HADHA(2), HADHB(3), HIBADH(1), HIBCH(1), HMGCL(1), HMGCS1(1), HMGCS2(3), HSD17B4(1), MCCC1(6), MCCC2(1), MCEE(1), MUT(4), OXCT1(3), PCCA(3), PCCB(6) 11412041 83 57 83 23 24 28 5 16 10 0 0.443 1.000 1.000 374 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(7), ATP4B(2), ATP6V0A1(3), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), ATP7A(9), ATP7B(2), COX10(2), COX4I1(1), COX6B1(2), COX6C(1), NDUFA10(3), NDUFB5(2), NDUFB6(1), NDUFB7(2), NDUFS1(4), NDUFV1(2), NDUFV2(2), PPA2(1), SDHA(2), SDHB(2), UQCRB(1), UQCRFS1(2) 10101736 74 57 74 21 16 23 7 15 13 0 0.398 1.000 1.000 375 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(11), COL4A2(14), COL4A3(10), COL4A4(11), COL4A5(4), COL4A6(10), P4HB(5), SLC23A1(2), SLC23A2(3), SLC2A1(1), SLC2A3(6) 6655402 77 57 77 18 14 41 1 9 12 0 0.313 1.000 1.000 376 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(3), AGT(1), AGTR1(5), AGTR2(3), CMA1(2), COL4A1(11), COL4A2(14), COL4A3(10), COL4A4(11), COL4A5(4), COL4A6(10) 6707563 74 56 74 20 11 42 1 9 11 0 0.568 1.000 1.000 377 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(1), ACAA2(1), ACADL(2), ACADM(1), ACADS(2), ACADVL(1), ACAT1(2), ACOX1(2), ACOX3(5), ACSL1(2), ACSL3(2), ACSL4(2), ACSL6(2), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), CPT1A(5), CPT1B(3), CPT1C(3), CPT2(2), CYP4A22(2), DCI(1), ECHS1(1), EHHADH(1), GCDH(2), HADH(1), HADHA(2), HADHB(3), HSD17B4(1), PECI(1) 12969310 72 56 72 24 16 32 4 12 8 0 0.595 1.000 1.000 378 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(5), C5(1), C6(18), C7(12), ICAM1(2), IL1A(1), IL6(1), ITGA4(4), ITGAL(1), ITGB1(5), ITGB2(5), SELP(11), SELPLG(1), TNF(1), VCAM1(5) 6596132 73 56 73 22 17 28 7 13 8 0 0.504 1.000 1.000 379 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(1), AKT1(1), AKT3(3), DAG1(2), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(14), ITPR3(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), NFKBIL2(5), PDK1(1), PHKA2(4), PIK3CB(4), PITX2(3), PLD1(7), PLD2(2), PLD3(1), VN1R1(4) 11908451 76 56 75 27 22 27 3 13 11 0 0.596 1.000 1.000 380 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(2), EEF1B2(1), EEF1D(1), EEF1G(2), EEF2(2), EEF2K(5), EIF2AK1(1), EIF2AK3(8), EIF2B1(2), EIF2B2(1), EIF2B3(1), EIF2B4(1), EIF2B5(3), EIF2S2(1), EIF4A1(5), EIF4A2(2), EIF4G1(10), EIF4G3(4), EIF5(3), EIF5B(1), ETF1(2), GSPT2(1), KIAA0664(3), PABPC1(4), PABPC3(9), PAIP1(2) 11591787 77 56 77 27 31 19 3 13 11 0 0.880 1.000 1.000 381 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 25 ADCY1(10), AKT1(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CREB1(1), GNAS(6), HRAS(5), MAPK1(1), MAPK14(1), MAPK3(1), PIK3R1(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCA(5), RAC1(1), RPS6KA1(2), RPS6KA5(4), SOS1(11) 7092120 65 55 64 15 18 20 6 16 5 0 0.270 1.000 1.000 382 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(1), B4GALT1(1), FBP2(1), G6PC(3), GALK2(1), GALT(1), GANAB(5), GCK(5), GLA(2), HK1(2), HK2(5), HK3(5), LCT(18), MGAM(5), PFKM(6), PFKP(2), PGM1(1) 8646403 64 55 64 29 18 22 3 13 8 0 0.880 1.000 1.000 383 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(2), FOS(2), HRAS(5), JAK1(2), JUN(3), MAP2K1(2), MAP2K4(1), MAP3K1(3), MAPK3(1), MAPK8(3), PDGFRA(10), PIK3R1(2), PLCG1(3), PRKCA(5), RAF1(1), RASA1(8), SHC1(2), SOS1(11), SRF(2), STAT1(2), STAT3(2), STAT5A(2) 8650740 74 55 72 17 25 24 5 9 11 0 0.202 1.000 1.000 384 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(3), BCR(2), BLNK(1), FOS(2), HRAS(5), JUN(3), LYN(2), MAP2K1(2), MAP3K1(3), MAPK1(1), MAPK3(1), MAPK8IP3(4), PAPPA(7), RAC1(1), RPS6KA1(2), RPS6KA3(1), SHC1(2), SOS1(11), SYK(1), VAV1(7), VAV2(4), VAV3(1) 8477056 66 55 64 17 20 22 7 11 6 0 0.297 1.000 1.000 385 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(8), ATR(13), BRCA1(12), BRCA2(12), CHEK1(5), CHEK2(3), FANCA(5), FANCC(2), FANCF(3), FANCG(3), MRE11A(1), RAD1(2), RAD17(2), RAD50(3), RAD51(1), RAD9A(2), TREX1(1) 11493740 78 54 78 17 27 19 5 17 10 0 0.338 1.000 1.000 386 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(2), AZIN1(1), BTG1(1), CLDN5(1), CLOCK(5), CRY1(3), CRY2(2), EIF4G2(2), ETV6(4), GSTM3(1), GSTP1(1), HERPUD1(1), HSPA8(3), IDI1(1), KLF9(1), MYF6(1), NCKAP1(7), NR1D2(1), PER1(6), PER2(2), PIGF(1), PPP1R3C(2), PSMA4(1), PURA(1), SF3A3(2), TUBB3(2), UCP3(3), UGP2(4), VAPA(1), ZFR(5) 9642096 68 54 68 18 15 21 5 17 10 0 0.448 1.000 1.000 387 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(10), CALM2(1), CREB1(1), FOS(2), GNAI1(3), GNAS(6), GNB1(1), HRAS(5), JUN(3), MAP2K1(2), MAPK3(1), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCA(5), RAF1(1), RPS6KA3(1), SYT1(4) 9193464 85 54 83 28 29 31 7 12 6 0 0.645 1.000 1.000 388 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(2), ACAT1(2), ADH5(1), AKR1B1(1), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), DLAT(1), DLD(2), GRHPR(2), HAGHL(1), LDHB(3), LDHC(3), LDHD(6), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(2), PC(2), PCK1(3), PDHA1(3), PDHA2(8), PKLR(4), PKM2(3) 9763990 68 54 68 31 18 27 3 13 7 0 0.951 1.000 1.000 389 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(2), CARS(8), DARS(1), EPRS(12), FARS2(2), HARS(2), IARS(3), KARS(3), LARS(1), LARS2(3), MARS(1), NARS(4), RARS(4), SARS(2), TARS(3), WARS(4), WARS2(2), YARS(1) 8494670 58 53 58 14 22 17 3 11 5 0 0.288 1.000 1.000 390 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GH1(2), GHR(3), HRAS(5), INSR(10), IRS1(7), JAK2(4), MAP2K1(2), MAPK1(1), MAPK3(1), PIK3R1(2), PLCG1(3), PRKCA(5), RAF1(1), RPS6KA1(2), SHC1(2), SLC2A4(2), SOS1(11), SRF(2), STAT5A(2) 8167291 67 53 66 15 16 28 6 10 7 0 0.111 1.000 1.000 391 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(5), AGXT(2), AGXT2(2), AKR1B10(2), AOC2(2), AOC3(3), BHMT(2), CBS(4), CHDH(1), CHKA(4), DAO(2), DLD(2), DMGDH(2), GATM(1), GCAT(1), GLDC(4), GNMT(1), PHGDH(2), PIPOX(1), PISD(1), PSAT1(3), PSPH(1), RDH11(1), RDH12(2), RDH13(1), SARDH(6), SARS(2), SARS2(3), SDS(2), TARS(3), TARS2(4) 11290298 72 53 72 25 24 20 4 16 8 0 0.566 1.000 1.000 392 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(4), ACE2(3), AGT(1), AGTR1(5), AGTR2(3), ANPEP(7), CMA1(2), CPA3(6), CTSA(3), CTSG(3), ENPEP(11), LNPEP(2), MAS1(3), MME(10), NLN(2), THOP1(1) 5602714 66 53 66 21 14 28 2 12 10 0 0.512 1.000 1.000 393 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 30 A1BG(1), AKT1(1), AKT3(3), BTK(7), GSK3A(3), IARS(3), INPP5D(8), PDK1(1), PPP1R13B(5), RPS6KA1(2), RPS6KA2(7), RPS6KA3(1), RPS6KB1(1), SFN(2), SHC1(2), SOS1(11), SOS2(7), TEC(4), YWHAB(1), YWHAQ(1) 8609336 71 53 71 19 23 22 3 10 13 0 0.440 1.000 1.000 394 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 24 ARNT(1), EIF2B1(2), EIF2B2(1), EIF2B3(1), EIF2B4(1), EIF2B5(3), EIF2S2(1), ELAVL1(1), FLT1(11), FLT4(5), HIF1A(1), HRAS(5), KDR(16), NOS3(2), PIK3R1(2), PLCG1(3), PRKCA(5), PTK2(6), PXN(3), SHC1(2), VHL(1) 8407191 73 53 72 28 23 26 4 10 10 0 0.828 1.000 1.000 395 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(10), CD3D(1), CD4(1), CREBBP(17), GNAS(6), GNB1(1), HLA-DRA(1), HLA-DRB1(2), LCK(3), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PTPRC(7), ZAP70(5) 6064524 65 52 65 23 18 20 6 15 6 0 0.771 1.000 1.000 396 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(2), C1QB(2), C1R(3), C1S(3), C2(2), C3(5), C5(1), C6(18), C7(12), C8A(7), C9(3), MASP1(9), MASP2(1), MBL2(4) 5715871 72 52 72 23 18 25 8 12 9 0 0.604 1.000 1.000 397 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(10), CD3D(1), CD4(1), CREBBP(17), GNAS(6), GNB1(1), HLA-DRA(1), HLA-DRB1(2), LCK(3), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PTPRC(7), ZAP70(5) 6064524 65 52 65 23 18 20 6 15 6 0 0.771 1.000 1.000 398 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(5), AGXT(2), AGXT2(2), AOC2(2), AOC3(3), BHMT(2), CBS(4), CHDH(1), CHKA(4), CPT1B(3), DAO(2), DLD(2), DMGDH(2), GATM(1), GCAT(1), GLDC(4), PISD(1), PLCB2(5), PLCG1(3), PLCG2(5), PSPH(1), SARDH(6), SARS(2), TARS(3) 11103348 66 52 66 23 24 20 2 14 6 0 0.586 1.000 1.000 399 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(5), ALDH3A1(2), ALDH3B2(1), AOC2(2), AOC3(3), DDC(6), EPX(5), ESCO1(2), ESCO2(1), GOT2(3), HPD(1), LPO(2), MPO(4), MYST3(11), MYST4(4), PNPLA3(1), PRDX6(2), SH3GLB1(1), TAT(1), TPO(10) 9053784 67 52 67 35 12 23 5 20 7 0 0.991 1.000 1.000 400 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(1), ALOX12B(1), ALOX15(3), ALOX15B(1), CYP2B6(4), CYP2C18(2), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2J2(1), CYP4A22(2), CYP4F2(3), CYP4F3(2), DHRS4(1), EPHX2(3), GGT1(1), GPX5(2), GPX6(2), LTA4H(2), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PTGES(1), PTGS1(2), PTGS2(1), TBXAS1(2) 10282907 73 52 73 33 23 24 9 9 8 0 0.893 1.000 1.000 401 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BRAF(8), CREB1(1), CREB3(2), CREB5(3), DUSP4(2), DUSP6(2), EEF2K(5), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MKNK2(1), MOS(4), NFKB1(2), RAP1A(1), RPS6KA1(2), RPS6KA2(7), RPS6KA3(1), SHC1(2), SOS1(11), SOS2(7), TRAF3(3) 7812826 69 52 69 15 22 20 6 9 12 0 0.181 1.000 1.000 402 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(1), ACAA2(1), ACADL(2), ACADM(1), ACADS(2), ACAT1(2), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH6A1(1), ALDH9A1(2), AOX1(13), BCAT1(1), BCKDHB(2), ECHS1(1), EHHADH(1), HADHA(2), HADHB(3), HIBADH(1), HMGCL(1), MCCC1(6), MCCC2(1), MCEE(1), MUT(4), OXCT1(3), PCCA(3), PCCB(6), SDS(2) 9550784 73 52 73 18 20 25 5 16 7 0 0.291 1.000 1.000 403 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(2), C1QB(2), C1R(3), C1S(3), C2(2), C3(5), C5(1), C6(18), C7(12), C8A(7), C8B(4), C9(3), MASP1(9) 5581646 71 51 71 25 17 26 8 12 8 0 0.748 1.000 1.000 404 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(7), POLB(1), POLD1(2), POLD2(1), POLD3(1), POLE(7), POLE2(2), POLE4(1), POLG(2), POLG2(2), POLI(3), POLK(3), POLL(2), POLQ(19), PRIM1(3), PRIM2(14), REV1(5), REV3L(4), RFC5(1) 10853991 80 51 79 26 23 25 3 19 10 0 0.765 1.000 1.000 405 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(9), CREBBP(17), CTNNB1(4), DVL1(2), EP300(9), FZD1(1), HDAC1(2), LEF1(3), PITX2(3), TRRAP(14), WNT1(1) 8758785 65 51 64 15 12 24 5 15 9 0 0.224 1.000 1.000 406 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP1(1), ARHGAP4(2), ARHGAP5(2), ARHGAP6(5), ARHGEF1(2), ARHGEF11(6), ARHGEF5(2), ARPC1A(4), BAIAP2(2), CFL1(2), DIAPH1(1), GSN(2), MYL2(2), MYLK(8), OPHN1(3), PIP5K1A(4), PIP5K1B(2), PPP1R12B(5), ROCK1(5), TLN1(6), VCL(2) 12044969 68 51 67 22 28 19 3 13 5 0 0.623 1.000 1.000 407 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(9), ATF2(3), BMP10(1), BMP4(1), BMP5(8), BMPR1A(3), BMPR2(1), CHRD(6), CTNNB1(4), DVL1(2), FZD1(1), MAP3K7(2), MEF2C(4), MYL2(2), NKX2-5(1), NPPB(1), RFC1(1), TGFB1(1), TGFB2(3), TGFBR2(3), TGFBR3(8), WNT1(1) 9613812 66 50 66 22 21 22 4 10 9 0 0.733 1.000 1.000 408 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(1), GUSB(2), UGDH(2), UGP2(4), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(3), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(4), UGT2B11(5), UGT2B15(3), UGT2B28(5), UGT2B4(8), UGT2B7(2), XYLB(1) 6950041 63 50 63 16 13 21 7 17 5 0 0.372 1.000 1.000 409 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(1), AKR1B10(2), ALDOA(1), ALDOB(2), FBP2(1), FPGT(4), FUK(2), GMPPA(2), HK1(2), HK2(5), HK3(5), KHK(2), MPI(1), MTMR1(1), MTMR2(2), MTMR6(5), PFKFB1(5), PFKL(2), PFKM(6), PFKP(2), PGM2(4), PMM1(1), RDH11(1), RDH12(2), RDH13(1), SORD(1), TPI1(3) 9849015 66 50 66 22 15 24 5 14 8 0 0.519 1.000 1.000 410 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(4), ACACA(2), ACACB(9), ACADM(1), ACAT1(2), ACSS1(3), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH6A1(1), ALDH7A1(1), ALDH9A1(2), ECHS1(1), EHHADH(1), HADHA(2), HIBCH(1), LDHAL6A(2), LDHAL6B(1), LDHB(3), LDHC(3), MCEE(1), MLYCD(1), MUT(4), PCCA(3), PCCB(6), SUCLA2(2), SUCLG2(1) 10492803 63 50 63 22 20 19 4 11 9 0 0.741 1.000 1.000 411 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(1), AASDH(6), AASDHPPT(1), AASS(11), ACAT1(2), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), BBOX1(2), DLST(1), DOT1L(5), ECHS1(1), EHHADH(1), EHMT1(5), EHMT2(1), GCDH(2), HADHA(2), PLOD1(4), PLOD2(5), PLOD3(5), SDS(2), TMLHE(1) 9784000 70 50 70 31 13 25 7 16 9 0 0.944 1.000 1.000 412 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 26 AKT1(1), AKT3(3), GSK3A(3), IL4R(2), IRS1(7), IRS2(1), JAK1(2), JAK3(7), MAP4K1(3), MAPK1(1), MAPK3(1), PDK1(1), PIK3CD(4), PIK3R1(2), PPP1R13B(5), RAF1(1), SHC1(2), SOS1(11), SOS2(7), STAT6(2) 9081329 66 50 66 27 16 24 2 15 9 0 0.874 1.000 1.000 413 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(2), ACTN2(10), ACTN3(2), BCAR1(6), CTNNA1(1), CTNNA2(27), CTNNB1(4), PTK2(6), PXN(3), VCL(2) 5049791 63 49 63 29 16 29 3 11 4 0 0.940 1.000 1.000 414 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(3), CHIA(4), CHIT1(5), CMAS(2), CTBS(3), CYB5R1(1), GFPT1(1), GFPT2(4), GNE(2), GNPDA2(4), HEXA(5), HK1(2), HK2(5), HK3(5), MTMR1(1), MTMR2(2), MTMR6(5), NAGK(2), NPL(2), RENBP(2), UAP1(2) 7576689 62 49 62 18 10 28 3 11 10 0 0.435 1.000 1.000 415 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 21 ARFIP2(1), CDK5(1), CDK5R1(1), CFL1(2), CHN1(2), MAP3K1(3), MYL2(2), MYLK(8), NCF2(3), PAK1(2), PDGFRA(10), PIK3R1(2), PLD1(7), PPP1R12B(5), RAC1(1), RALBP1(1), RPS6KB1(1), TRIO(8), VAV1(7), WASF1(1) 8697760 68 49 68 23 25 24 4 12 3 0 0.661 1.000 1.000 416 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(2), ABAT(4), ADSL(1), ADSS(1), AGXT(2), AGXT2(2), ASL(4), ASNS(5), CAD(11), DARS(1), DDO(2), GAD1(5), GAD2(6), GOT2(3), GPT(1), GPT2(4), NARS(4), PC(2) 6914471 60 48 60 21 17 21 2 14 6 0 0.602 1.000 1.000 417 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(1), CFL1(2), GNAS(6), GNB1(1), HRAS(5), MAP2K1(2), MAPK1(1), MAPK3(1), MYL2(2), NOX1(2), PIK3C2G(8), PLCB1(8), PPP1R12B(5), PRKCA(5), PTK2(6), RAF1(1), ROCK2(3) 6693867 59 48 58 22 14 25 4 11 5 0 0.884 1.000 1.000 418 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(7), CD2(1), CD33(3), CD5(2), CD7(1), IFNA1(1), IFNB1(2), IFNG(1), IL10(2), IL12A(1), IL12B(3), IL3(1), IL4(2), ITGAX(9), TLR2(3), TLR4(10), TLR7(3), TLR9(2) 4931288 54 48 53 18 10 22 3 13 6 0 0.503 1.000 1.000 419 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 21 ARHGAP5(2), DIAPH1(1), FYN(5), GSN(2), HRAS(5), ITGA1(4), ITGB1(5), MAP2K1(2), MAPK1(1), MAPK3(1), MYL2(2), MYLK(8), PIK3R1(2), PTK2(6), PXN(3), RAF1(1), ROCK1(5), SHC1(2), TLN1(6) 9323921 63 48 62 19 21 21 6 12 3 0 0.580 1.000 1.000 420 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(1), ACAA2(1), ACAD8(2), ACAD9(3), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), AKR1B10(2), AKR1C4(1), AKR1D1(3), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), BAAT(2), CEL(1), CYP27A1(1), CYP7A1(6), HADHB(3), LIPA(2), RDH11(1), RDH12(2), RDH13(1), SLC27A5(4), SOAT1(1), SOAT2(2), SRD5A1(2), SRD5A2(2) 8408353 62 48 62 19 15 25 0 15 7 0 0.379 1.000 1.000 421 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG10B(1), ALG12(1), ALG13(8), ALG2(3), ALG5(2), ALG6(2), ALG8(1), ALG9(1), B4GALT1(1), B4GALT3(3), DDOST(1), DPM1(1), FUT8(2), GANAB(5), MAN1A1(4), MAN1A2(5), MAN1C1(3), MAN2A1(5), MGAT1(2), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT4B(1), MGAT5(6), MGAT5B(3), RPN1(1), ST6GAL1(2), STT3B(1) 11216478 74 48 74 28 29 27 2 9 7 0 0.772 1.000 1.000 422 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(13), BST1(1), C9orf95(1), CD38(2), ENPP1(8), ENPP3(6), NADK(1), NADSYN1(7), NMNAT2(2), NMNAT3(1), NNT(10), NT5C1A(2), NT5C1B(2), NT5C2(3), NT5C3(3), NT5E(2), NUDT12(2) 5697708 66 48 66 17 20 24 3 11 8 0 0.290 1.000 1.000 423 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(3), DLAT(1), DLD(2), DLST(1), FH(2), IDH3A(1), IDH3B(4), IDH3G(2), MDH1(1), MDH2(1), OGDH(3), PC(2), PDHA1(3), PDHA2(8), PDHX(1), PDK1(1), PDK2(2), PDK3(3), PDK4(3), PDP2(4), SDHA(2), SDHB(2), SUCLA2(2), SUCLG2(1) 7507034 55 48 55 21 11 22 3 13 6 0 0.801 1.000 1.000 424 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(1), ALOX15(3), CYP4F2(3), CYP4F3(2), EPX(5), GGT1(1), LPO(2), LTA4H(2), MPO(4), PLA2G2A(1), PLA2G2E(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PRDX1(1), PRDX6(2), PTGS1(2), PTGS2(1), TBXAS1(2), TPO(10) 7384189 61 48 61 30 13 23 9 11 5 0 0.950 1.000 1.000 425 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(6), CALM2(1), CRKL(1), HRAS(5), JUN(3), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(1), MAP3K1(3), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(3), PAK1(2), PLCG1(3), PRKCA(5), RAC1(1), RAF1(1), SHC1(2), SOS1(11), SYT1(4) 7514232 61 48 59 21 16 22 5 14 4 0 0.739 1.000 1.000 426 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(2), CHUK(2), FOS(2), IKBKB(2), IRAK1(4), JUN(3), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP3K1(3), MAP3K14(1), MAP3K7(2), MAPK14(1), MAPK8(3), NFKB1(2), PPARA(1), RELA(3), TLR2(3), TLR3(2), TLR4(10), TLR7(3), TLR9(2), TOLLIP(1), TRAF6(5) 9644644 63 48 62 31 18 22 5 9 9 0 0.982 1.000 1.000 427 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(9), BTRC(1), CCND1(1), CREBBP(17), CSNK1A1(2), CSNK1D(2), CSNK2A1(2), CTBP1(2), CTNNB1(4), DVL1(2), FZD1(1), HDAC1(2), MAP3K7(2), MYC(1), NLK(2), PPARD(2), TLE1(4), WIF1(6), WNT1(1) 7765622 63 48 63 15 18 22 6 8 9 0 0.272 1.000 1.000 428 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(4), ABP1(5), ACADL(2), ACADM(1), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), AOC2(2), AOC3(3), CNDP1(3), DPYD(9), DPYS(6), ECHS1(1), EHHADH(1), GAD1(5), GAD2(6), HADHA(2), MLYCD(1), SDS(2), SMS(2) 7698099 67 47 67 26 14 28 4 13 8 0 0.793 1.000 1.000 429 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(2), ACP2(1), ACPT(2), ALPI(1), ALPL(3), ALPP(3), ALPPL2(1), CYP19A1(4), CYP1A1(7), CYP1A2(1), CYP2A13(1), CYP2A6(5), CYP2A7(1), CYP2B6(4), CYP2C18(2), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2D6(2), CYP2F1(3), CYP2J2(1), CYP3A4(1), CYP3A7(1), CYP4B1(3), CYP4F8(4), PON1(7) 7743427 74 47 74 33 21 24 6 18 5 0 0.901 1.000 1.000 430 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 38 ANAPC1(5), ANAPC4(3), ANAPC5(5), BTRC(1), CDC16(1), CDC20(1), CDC23(1), CDC27(3), CUL1(4), FBXW11(1), FBXW7(10), ITCH(2), RBX1(1), SKP1(1), SKP2(2), SMURF1(2), UBA1(3), UBE2C(1), UBE2D1(1), UBE2D2(2), UBE2E2(2), UBE2E3(2), VHL(1), WWP1(3), WWP2(2) 10249771 60 47 58 20 15 18 8 9 10 0 0.831 1.000 1.000 431 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(3), CHAT(9), DBH(2), DDC(6), GAD1(5), GAD2(6), HDC(6), PAH(3), PNMT(2), SLC18A3(8), TH(2), TPH1(2) 3804590 54 46 54 20 13 25 4 9 3 0 0.560 1.000 1.000 432 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(10), AKT1(1), GNAI1(3), GNB1(1), ITGAV(4), ITGB3(4), MAPK1(1), MAPK3(1), PDGFRA(10), PIK3R1(2), PLCB1(8), PRKCA(5), PTK2(6), RAC1(1), SMPD1(4), SMPD2(1) 6684849 62 46 62 21 21 20 5 15 1 0 0.666 1.000 1.000 433 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 26 ARHGDIB(2), CASP10(3), CASP7(2), CASP8(2), CFLAR(2), DAXX(3), DFFB(2), FADD(1), FAF1(1), JUN(3), MAP2K4(1), MAP3K1(3), MAP3K7(2), MAPK8(3), PAK1(2), PAK2(1), PRKDC(12), PTPN13(9), RIPK2(2), SPTAN1(4) 10534864 60 46 59 17 20 16 1 13 10 0 0.554 1.000 1.000 434 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 25 AKT1(1), APC(9), CCND1(1), CD14(2), CTNNB1(4), DVL1(2), FZD1(1), GJA1(4), GNAI1(3), IRAK1(4), LBP(4), LEF1(3), NFKB1(2), PDPK1(1), PIK3R1(2), RELA(3), TLR4(10), TOLLIP(1), WNT1(1) 7530780 58 46 58 20 17 14 10 9 8 0 0.786 1.000 1.000 435 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 33 AKT1(1), BCL2L1(1), CBL(3), CFLAR(2), CRKL(1), E2F1(2), FOS(2), HRAS(5), IL2RB(2), IL2RG(1), IRS1(7), JAK1(2), JAK3(7), MAPK1(1), MAPK3(1), MYC(1), NMI(2), PIK3R1(2), RAF1(1), RPS6KB1(1), SHC1(2), SOCS3(1), SOS1(11), STAT5A(2), SYK(1) 8992732 62 46 61 23 17 25 2 10 8 0 0.753 1.000 1.000 436 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 15 CREBBP(17), EP300(9), FYN(5), IL2RG(1), IL7(1), IL7R(8), JAK1(2), JAK3(7), LCK(3), NMI(2), PIK3R1(2), STAT5A(2) 6821693 59 46 57 16 11 17 4 19 8 0 0.389 1.000 1.000 437 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 31 GORASP1(1), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK11(2), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(3), MAPK8IP1(2), MAPK8IP3(4), MAPK9(1), MAPKAPK5(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), NFKBIL2(5), PIK3CD(4), PIK3R1(2), SYT1(4), TRAF3(3), TRAF5(2), TRAF6(5) 8297627 57 46 57 16 18 23 2 7 7 0 0.281 1.000 1.000 438 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 22 BCAR1(6), CXCR4(5), GNAI1(3), GNB1(1), HRAS(5), MAP2K1(2), MAPK1(1), MAPK3(1), NFKB1(2), PIK3C2G(8), PIK3R1(2), PLCG1(3), PRKCA(5), PTK2(6), PXN(3), RAF1(1), RELA(3) 6775563 57 45 56 22 17 20 5 12 3 0 0.806 1.000 1.000 439 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(3), GNS(1), GUSB(2), HEXA(5), HGSNAT(1), HPSE(3), HPSE2(2), HYAL1(3), IDS(1), IDUA(2), LCT(18), SPAM1(7) 5404724 50 45 50 16 12 17 2 12 7 0 0.519 1.000 1.000 440 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(7), DLG4(1), EPHB2(6), F2RL1(3), F2RL2(1), F2RL3(1), JUN(3), MAP2K5(1), MAPK1(1), MAPK7(1), MAPK8(3), MYEF2(4), PLD1(7), PLD2(2), PLD3(1), PTK2(6), RAF1(1), RASAL1(8), TEC(4), VAV1(7) 7256214 68 45 67 25 21 27 4 10 6 0 0.717 1.000 1.000 441 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(1), CDC42(1), CREB1(1), CREB3(2), CREB5(3), DUSP10(5), EEF2K(5), GADD45A(1), IL1R1(1), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP3K4(4), MAP3K5(4), MAP3K7(2), MAPK1(1), MAPK11(2), MAPK13(2), MAPK14(1), MAPKAPK2(1), MAPKAPK5(3), MKNK2(1), MYEF2(4), NFKB1(2), NR2C2(3), SRF(2), TRAF6(5) 8834077 63 45 63 25 23 21 4 7 8 0 0.868 1.000 1.000 442 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2B(1), CAMK2D(1), DAG1(2), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(14), ITPR3(3), NFAT5(3), PDE6A(4), PDE6B(3), PDE6C(1), PDE6H(3), SLC6A13(5), TF(6) 9499351 60 45 59 22 16 23 4 8 9 0 0.665 1.000 1.000 443 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(5), AGT(1), AGTR2(3), EDNRA(1), EDNRB(5), EGF(6), EGFR(7), FOS(2), HRAS(5), JUN(3), MYC(1), NFKB1(2), PLCG1(3), PRKCA(5), RELA(3) 5445118 52 44 49 18 13 19 3 8 9 0 0.638 1.000 1.000 444 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(4), ABP1(5), ACADM(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), AOC2(2), AOC3(3), CNDP1(3), DPYD(9), DPYS(6), ECHS1(1), EHHADH(1), GAD1(5), GAD2(6), HADHA(2), HIBCH(1), MLYCD(1), SMS(2) 7147393 61 44 61 25 13 25 3 12 8 0 0.839 1.000 1.000 445 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(2), CREBBP(17), EP300(9), IKBKB(2), IL1B(1), MAP2K3(3), MAP2K6(2), MAP3K14(1), MAP3K7(2), MAPK11(2), MAPK14(1), NFKB1(2), NR3C1(1), RELA(3), TGFBR2(3), TLR2(3), TNF(1) 7847285 55 44 54 20 11 18 3 12 11 0 0.797 1.000 1.000 446 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(3), CDC42(1), CREB1(1), DAXX(3), HRAS(5), HSPB2(1), MAP2K4(1), MAP2K6(2), MAP3K1(3), MAP3K5(4), MAP3K7(2), MAP3K9(3), MAPK14(1), MAPKAPK2(1), MAPKAPK5(3), MEF2A(2), MEF2C(4), MEF2D(3), MYC(1), PLA2G4A(7), RAC1(1), RPS6KA5(4), SHC1(2), STAT1(2), TGFB1(1), TGFB2(3), TRADD(1) 9723880 65 44 64 28 20 26 4 11 4 0 0.948 1.000 1.000 447 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRA(2), CP(2), CPOX(2), EPRS(12), FECH(2), GUSB(2), HCCS(1), PPOX(1), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(3), UGT1A9(3), UGT2B15(3), UGT2B4(8), UROD(1), UROS(1) 7265216 54 44 54 16 12 23 5 11 3 0 0.502 1.000 1.000 448 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(4), ACACA(2), ACADL(2), ACADM(1), ACAT1(2), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH6A1(1), ALDH9A1(2), ECHS1(1), EHHADH(1), HADHA(2), LDHB(3), LDHC(3), MCEE(1), MLYCD(1), MUT(4), PCCA(3), PCCB(6), SDS(2), SUCLA2(2), SUCLG2(1) 8753790 54 44 54 15 15 19 4 9 7 0 0.495 1.000 1.000 449 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ABAT(4), ACADS(2), ACAT1(2), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH5A1(1), ALDH9A1(2), ECHS1(1), EHHADH(1), GAD1(5), GAD2(6), HADHA(2), HMGCL(1), OXCT1(3), PDHA1(3), PDHA2(8), SDHB(2), SDS(2) 6826931 56 43 56 25 13 25 3 8 7 0 0.921 1.000 1.000 450 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(2), C1QB(2), C1R(3), C1S(3), C2(2), C3(5), C5(1), C6(18), C7(12), C8A(7), C9(3) 4705477 58 43 58 19 14 20 8 8 8 0 0.671 1.000 1.000 451 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(2), CSF1R(3), E2F1(2), ETS1(2), ETV3(2), FOS(2), HDAC5(1), HRAS(5), JUN(3), NCOR2(7), RBL1(5), RBL2(8), SIN3A(5), SIN3B(3) 6870586 50 43 48 12 17 18 3 7 5 0 0.228 1.000 1.000 452 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 29 AKT1(1), CABIN1(5), CALM2(1), CAMK1G(3), HDAC5(1), IGF1(3), IGF1R(1), INSR(10), MAP2K6(2), MAPK14(1), MAPK7(1), MEF2A(2), MEF2C(4), MEF2D(3), MYOD1(1), NFATC1(3), NFATC2(4), PIK3R1(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), SYT1(4) 8611082 62 43 62 26 22 22 3 8 7 0 0.824 1.000 1.000 453 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(3), ADCY1(10), CAP1(2), CCNB1(2), CDC25C(1), GNAI1(3), GNAS(6), GNB1(1), HRAS(5), MAPK1(1), MAPK3(1), MYT1(4), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), RPS6KA1(2) 5412451 52 43 51 21 12 17 6 13 4 0 0.886 1.000 1.000 454 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(3), ACTN1(2), ACTN2(10), ACTN3(2), CAPN1(2), CAPNS2(1), ITGA1(4), ITGB1(5), ITGB3(4), PTK2(6), PXN(3), RAC1(1), SPTAN1(4), TLN1(6) 7542709 53 43 53 21 13 18 2 14 6 0 0.850 1.000 1.000 455 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM2(1), CHUK(2), EGR2(6), EGR3(2), MAP3K1(3), MYC(1), NFATC1(3), NFATC2(4), NFKB1(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), RELA(3), SYT1(4), VIP(1), VIPR2(3) 7373715 59 43 59 22 14 24 5 9 7 0 0.764 1.000 1.000 456 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(1), CDK5R1(1), CSNK1D(2), DRD1(1), DRD2(4), GRM1(13), PLCB1(8), PPP1CA(1), PPP1R1B(1), PPP3CA(4), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3) 4237842 47 42 47 15 12 20 4 7 4 0 0.495 1.000 1.000 457 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(3), EPHA4(1), EPHB1(13), FYN(5), ITGA1(4), ITGB1(5), L1CAM(1), LYN(2), RAP1B(1), SELP(11) 4181179 46 42 46 26 6 17 3 11 9 0 0.996 1.000 1.000 458 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(2), ARSB(2), ARSD(1), ARSE(2), GAL3ST1(1), GALC(2), GBA(4), GLA(2), LCT(18), NEU1(3), NEU2(2), NEU4(2), PPAP2B(1), SMPD1(4), SMPD2(1), SPTLC1(1), SPTLC2(3), UGCG(1) 6383971 52 42 52 19 14 19 3 12 4 0 0.657 1.000 1.000 459 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(2), ALOX15(3), CYP1A2(1), CYP2C18(2), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2J2(1), CYP3A4(1), CYP3A43(4), CYP3A7(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), RDH11(1), RDH12(2), RDH13(1) 6346784 55 42 55 17 20 17 6 5 7 0 0.404 1.000 1.000 460 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(2), FBP2(1), GOT2(3), GPT(1), GPT2(4), MDH1(1), MDH2(1), ME1(2), ME3(2), PGK1(2), PGK2(4), PKLR(4), PKM2(3), RPIA(2), TKT(1), TKTL1(1), TKTL2(12), TPI1(3) 5332929 50 42 50 20 8 20 6 9 7 0 0.763 1.000 1.000 461 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), CYP2C19(9), CYP2C9(3), DHRS2(2), DHRSX(4), ECHS1(1), EHHADH(1), ESCO1(2), ESCO2(1), HADHA(2), MYST3(11), MYST4(4), PNPLA3(1), SH3GLB1(1) 8187108 52 42 52 23 15 18 0 10 9 0 0.930 1.000 1.000 462 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(17), EP300(9), LPL(3), NCOA1(6), NCOA2(12), RXRA(2) 4903643 49 42 48 17 10 18 3 11 7 0 0.793 1.000 1.000 463 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(9), CDH1(3), CREBBP(17), EP300(9), MAP2K1(2), MAP3K7(2), MAPK3(1), SKIL(1), TGFB1(1), TGFB2(3), TGFBR2(3) 6794970 51 42 50 14 13 16 2 13 7 0 0.554 1.000 1.000 464 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(5), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3B2(1), ALDH9A1(2), AOC2(2), AOC3(3), CNDP1(3), DDC(6), HAL(2), HARS(2), HDC(6), HNMT(3), PRPS1(2), PRPS2(1) 6463570 48 41 48 25 6 24 3 12 3 0 0.949 1.000 1.000 465 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(2), DERA(1), FBP2(1), G6PD(1), GPI(5), H6PD(3), PFKL(2), PFKM(6), PFKP(2), PGD(1), PGM1(1), PRPS1(2), PRPS1L1(3), PRPS2(1), RBKS(1), RPIA(2), TALDO1(1), TKT(1), TKTL1(1), TKTL2(12) 6439869 50 41 50 18 5 20 6 10 9 0 0.634 1.000 1.000 466 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(2), EXT2(1), EXTL1(5), EXTL2(1), EXTL3(1), HS3ST2(2), HS3ST3A1(1), HS3ST5(4), HS6ST1(5), HS6ST3(3), NDST1(4), NDST2(2), NDST3(4), NDST4(13) 5457456 48 41 48 18 13 18 5 8 4 0 0.681 1.000 1.000 467 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(2), IFNA1(1), IFNB1(2), IKBKB(2), IL1A(1), IL1B(1), IL1R1(1), IL1RAP(2), IL6(1), IRAK1(4), IRAK2(1), IRAK3(4), JUN(3), MAP2K3(3), MAP2K6(2), MAP3K1(3), MAP3K14(1), MAP3K7(2), MAPK14(1), MAPK8(3), NFKB1(2), RELA(3), TGFB1(1), TGFB2(3), TNF(1), TOLLIP(1), TRAF6(5) 7824598 56 41 55 21 17 21 3 9 6 0 0.797 1.000 1.000 468 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(5), ABCC2(6), ABCG2(2), BCHE(12), CES1(2), CES2(1), CYP3A4(1), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(3), UGT1A9(3) 6058731 46 41 46 14 9 20 3 12 2 0 0.424 1.000 1.000 469 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(5), ALDH3A1(2), ALDH3B2(1), AOC2(2), AOC3(3), DDC(6), EPX(5), GOT2(3), HPD(1), LPO(2), MPO(4), PRDX1(1), PRDX6(2), TAT(1), TPO(10) 5808702 48 41 48 26 7 19 6 14 2 0 0.972 1.000 1.000 470 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2R(2), F2RL3(1), GNAI1(3), GNB1(1), HRAS(5), ITGA1(4), ITGB1(5), MAP2K1(2), MAPK1(1), MAPK3(1), PLA2G4A(7), PLCB1(8), PRKCA(5), PTGS1(2), PTK2(6), RAF1(1), SYK(1), TBXAS1(2) 6440993 57 41 56 21 14 20 5 13 5 0 0.839 1.000 1.000 471 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(9), CERK(6), CREB1(1), CREB3(2), CREB5(3), DAG1(2), EPHB2(6), FOS(2), ITPKA(1), ITPKB(6), JUN(3), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK8(3), MAPK8IP1(2), MAPK8IP3(4), MAPK9(1) 7529585 55 41 54 19 20 19 4 4 8 0 0.691 1.000 1.000 472 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(4), BAK1(1), BAX(1), BCL2L1(1), BIRC2(1), BIRC3(3), CASP2(1), CASP7(2), CASP8(2), CASP9(3), FADD(1), FAS(1), FASLG(1), GZMB(1), JUN(3), MAP2K4(1), MAP3K1(3), MAP3K14(1), MAPK10(1), MCL1(2), MDM2(2), MYC(1), NFKB1(2), PARP1(3), PRF1(1), RELA(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF1(4) 9708232 55 40 53 32 20 14 3 9 9 0 0.998 1.000 1.000 473 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 20 AKT1(1), EIF4A1(5), EIF4A2(2), EIF4G1(10), EIF4G2(2), EIF4G3(4), GHR(3), IRS1(7), MAPK1(1), MAPK14(1), MAPK3(1), PABPC1(4), PDK2(2), PDPK1(1), PIK3R1(2), PRKCA(5), RPS6KB1(1) 6664943 52 40 52 17 19 17 6 6 4 0 0.749 1.000 1.000 474 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(3), ABP1(5), AOC2(2), AOC3(3), CES1(2), CES7(2), DDHD1(5), ESCO1(2), ESCO2(1), LIPA(2), MYST3(11), MYST4(4), PLA1A(6), PNPLA3(1), PRDX6(2), SH3GLB1(1) 6727165 52 40 52 23 13 16 1 17 5 0 0.947 1.000 1.000 475 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(1), CD3D(1), CXCR3(1), ETV5(1), IFNG(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(4), IL18R1(2), JAK2(4), JUN(3), MAP2K6(2), MAPK14(1), MAPK8(3), STAT4(5), TYK2(8) 4919124 44 40 43 13 14 18 2 4 6 0 0.558 1.000 1.000 476 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(2), FADD(1), IKBKB(2), IL1A(1), IL1R1(1), IRAK1(4), MAP3K1(3), MAP3K14(1), MAP3K7(2), NFKB1(2), RELA(3), TLR4(10), TNF(1), TNFAIP3(5), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(5) 6444905 47 40 47 21 10 18 6 6 7 0 0.945 1.000 1.000 477 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(1), ANXA4(1), ANXA5(3), ANXA6(5), CYP11A1(2), EDNRA(1), EDNRB(5), HSD11B1(3), HSD11B2(1), PLA2G4A(7), PRL(1), PTGDR(5), PTGER2(2), PTGER4(2), PTGFR(5), PTGIR(1), PTGS1(2), PTGS2(1), TBXAS1(2) 5472131 50 40 50 19 8 19 4 9 10 0 0.751 1.000 1.000 478 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(11), APOA4(3), APOC2(2), APOC3(2), CYP7A1(6), DGAT1(1), HMGCR(1), LDLR(4), LIPC(2), LPL(3), LRP1(15), SCARB1(3), SOAT1(1) 7263820 54 40 54 21 17 21 1 10 5 0 0.685 1.000 1.000 479 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 27 ARHGDIB(2), BAG4(1), CASP2(1), CASP8(2), CRADD(1), DFFB(2), FADD(1), JUN(3), MADD(6), MAP2K4(1), MAP3K1(3), MAP3K7(2), MAPK8(3), PAK1(2), PAK2(1), PRKDC(12), SPTAN1(4), TNF(1), TNFRSF1A(2), TRADD(1) 9958442 51 40 50 24 14 16 0 11 10 0 0.960 1.000 1.000 480 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(10), AKT1(1), BAX(1), BCL2L1(1), CSF2RB(5), IGF1(3), IGF1R(1), IL3(1), KIT(7), PIK3R1(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3) 5225648 43 39 43 14 14 14 2 10 3 0 0.524 1.000 1.000 481 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(3), FUCA1(2), FUCA2(1), HEXA(5), LCT(18), MAN2B1(2), MAN2B2(3), MAN2C1(6), MANBA(2), NEU1(3), NEU2(2), NEU4(2) 5380091 49 39 49 15 12 15 4 14 4 0 0.440 1.000 1.000 482 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(2), FOS(2), HRAS(5), IL2RB(2), IL2RG(1), JAK1(2), JAK3(7), JUN(3), LCK(3), MAP2K1(2), MAPK3(1), MAPK8(3), RAF1(1), SHC1(2), SOS1(11), STAT5A(2), SYK(1) 6179385 50 39 48 14 14 18 3 10 5 0 0.403 1.000 1.000 483 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 18 ADCY1(10), ARHGEF1(2), F2R(2), F2RL3(1), GNA12(2), GNA13(1), GNAI1(3), GNB1(1), MAP3K7(2), PIK3R1(2), PLCB1(8), PPP1R12B(5), PRKCA(5), ROCK1(5) 6250764 49 39 49 15 16 16 4 10 3 0 0.561 1.000 1.000 484 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(1), ALDOA(1), ALDOB(2), FBP2(1), FPGT(4), GCK(5), GMPPA(2), HK1(2), HK2(5), HK3(5), KHK(2), MPI(1), PFKFB1(5), PFKM(6), PFKP(2), PMM1(1), SORD(1), TPI1(3) 6342149 49 38 49 18 15 20 2 8 4 0 0.562 1.000 1.000 485 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACO1(2), ACO2(3), CLYBL(1), DLD(2), DLST(1), FH(2), IDH1(2), IDH3A(1), IDH3B(4), IDH3G(2), MDH1(1), MDH2(1), OGDH(3), OGDHL(6), PC(2), PCK1(3), PCK2(1), SDHA(2), SDHB(2), SUCLA2(2), SUCLG2(1) 7895341 44 38 44 25 8 19 1 10 6 0 0.985 1.000 1.000 486 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(2), CREBBP(17), EP300(9), FADD(1), HDAC3(1), IKBKB(2), NFKB1(2), RELA(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(5) 5930182 47 38 46 12 11 14 4 10 8 0 0.356 1.000 1.000 487 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(5), C5(1), C6(18), C7(12), C8A(7), C9(3) 3367043 46 37 46 15 9 17 8 6 6 0 0.738 1.000 1.000 488 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(1), CREB1(1), CREBBP(17), EP300(9), NCOA3(4), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), RARA(1), RXRA(2) 5469179 46 37 45 13 9 17 2 13 5 0 0.500 1.000 1.000 489 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(10), CREM(2), FHL5(3), FSHB(2), FSHR(15), GNAS(6), XPO1(2) 2521554 40 37 40 16 11 10 4 13 2 0 0.920 1.000 1.000 490 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(3), F2R(2), F3(1), F5(18), F7(2), FGA(5), FGB(4), FGG(2), PROS1(5), SERPINC1(7) 4338527 49 37 49 13 17 14 6 9 3 0 0.477 1.000 1.000 491 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 21 AKT1(1), BCR(2), CRKL(1), FOS(2), HRAS(5), JAK2(4), JUN(3), MAP2K1(2), MAP2K4(1), MAP3K1(3), MAPK3(1), MAPK8(3), MYC(1), PIK3R1(2), RAF1(1), SOS1(11), STAT1(2), STAT5A(2) 6851698 47 37 45 14 18 14 4 8 3 0 0.557 1.000 1.000 492 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), HEXA(5), LCT(18), SLC33A1(3), ST3GAL1(4), ST3GAL5(2), ST6GALNAC3(5), ST6GALNAC4(1), ST6GALNAC5(3), ST8SIA1(3) 4350925 45 37 45 15 13 19 2 6 5 0 0.418 1.000 1.000 493 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(5), CALM2(1), CAPN2(2), CAPNS2(1), EP300(9), HDAC1(2), MEF2D(3), NFATC1(3), NFATC2(4), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(5), SYT1(4) 6450147 49 37 48 14 15 16 5 6 7 0 0.506 1.000 1.000 494 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(10), ADRB2(4), GNAS(6), PLCE1(14), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3) 3892558 45 37 44 14 13 16 3 9 4 0 0.590 1.000 1.000 495 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(1), AP2A1(2), AP2M1(1), ARF1(1), BTK(7), EEA1(3), GRASP(1), GSK3A(3), LYN(2), PDPK1(1), PFKL(2), PFKM(6), PFKP(2), PLCG1(3), PRKCE(3), PRKCZ(1), RAC1(1), RPS6KB1(1), VAV2(4) 6624084 45 37 45 20 9 13 7 7 9 0 0.937 1.000 1.000 496 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), GTF2A1(1), GTF2B(2), GTF2E1(2), GTF2F1(1), HDAC3(1), NCOA1(6), NCOA2(12), NCOA3(4), NCOR2(7), POLR2A(2), RARA(1), RXRA(2) 6611801 42 37 42 19 8 18 2 8 6 0 0.922 1.000 1.000 497 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(1), ACAA2(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH7(1), ADHFE1(2), AKR1C4(1), AKR1D1(3), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), BAAT(2), CEL(1), CYP27A1(1), CYP7A1(6), HADHB(3), SOAT2(2), SRD5A1(2), SRD5A2(2) 6160205 46 36 46 14 11 20 0 11 4 0 0.442 1.000 1.000 498 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(3), CSF1R(3), EGF(6), EGFR(7), MET(4), PDGFRA(10), PRKCA(5), SH3GLB1(1), SH3KBP1(4) 5134556 43 36 42 14 13 15 4 5 6 0 0.647 1.000 1.000 499 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(2), BAIAP2(2), CASP1(1), CASP7(2), CASP8(2), GAPDH(2), INSR(10), ITCH(2), MAGI1(8), MAGI2(12), RERE(3), WWP1(3), WWP2(2) 6354020 51 36 51 17 11 16 2 12 10 0 0.716 1.000 1.000 500 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 19 AKT1(1), EIF4A1(5), EIF4A2(2), EIF4B(5), EIF4G1(10), EIF4G2(2), EIF4G3(4), PDK2(2), PDPK1(1), PIK3R1(2), RPS6(1), RPS6KB1(1), TSC1(5), TSC2(5) 6546676 46 36 46 15 19 13 4 3 7 0 0.705 1.000 1.000 501 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(6), DYRK1B(3), GLI2(6), GLI3(9), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), SHH(2), SMO(1), SUFU(2) 4387307 40 36 40 16 13 15 4 5 3 0 0.765 1.000 1.000 502 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM2(1), CDKN1A(2), MARCKS(1), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(5), SP1(2), SP3(1), SYT1(4) 5518793 44 35 44 13 14 19 3 4 4 0 0.519 1.000 1.000 503 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 29 ABP1(5), ACY1(2), ADC(1), AGMAT(1), ALDH18A1(3), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), AMD1(1), AOC2(2), AOC3(3), ARG1(2), ASL(4), GATM(1), NAGS(1), ODC1(1), OTC(3), SMS(2) 6959837 41 35 41 16 9 14 4 10 4 0 0.728 1.000 1.000 504 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT3(1), AGPAT4(1), AGPAT6(1), AGPS(1), CHPT1(1), ENPP2(7), ENPP6(3), PAFAH1B1(1), PAFAH1B2(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLD1(7), PLD2(2), PPAP2B(1) 6155800 49 35 49 24 12 20 5 6 6 0 0.953 1.000 1.000 505 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(3), FUCA1(2), FUCA2(1), HEXA(5), LCT(18), MAN2C1(6), MANBA(2), NEU1(3), NEU2(2), NEU4(2) 4366068 44 35 44 13 10 14 3 13 4 0 0.436 1.000 1.000 506 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(2), CCR1(3), CCR2(1), CCR3(1), CCR4(3), CCR5(1), CD4(1), CXCR3(1), CXCR4(5), IFNG(1), IFNGR1(4), IFNGR2(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(4), IL18R1(2), IL4(2), IL4R(2), TGFB1(1), TGFB2(3) 5290782 45 35 45 19 12 14 1 10 8 0 0.847 1.000 1.000 507 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(2), FBP2(1), G6PD(1), GPI(5), H6PD(3), PFKM(6), PFKP(2), PGD(1), PGM1(1), PRPS1(2), PRPS1L1(3), PRPS2(1), RBKS(1), RPIA(2), TAL1(4), TALDO1(1), TKT(1) 5409298 38 35 38 16 5 12 4 8 9 0 0.795 1.000 1.000 508 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CDK7(1), ERCC3(1), GTF2B(2), GTF2E1(2), GTF2H1(2), GTF2H4(2), ILK(2), POLR1A(3), POLR1B(2), POLR2A(2), POLR2B(6), POLR2E(2), POLR3B(1), POLR3D(2), POLR3E(4), POLR3H(2), TAF5(1), TAF9(2) 9272390 39 35 39 17 12 13 2 5 7 0 0.902 1.000 1.000 509 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(3), CR1(6), CR2(12), FCGR2B(3), HLA-DRA(1), HLA-DRB1(2), ICAM1(2), ITGAL(1), ITGB2(5), PTPRC(7) 4044777 42 34 42 15 15 12 2 10 3 0 0.753 1.000 1.000 510 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(4), BIRC2(1), BIRC3(3), CASP10(3), CASP7(2), CASP8(2), CASP9(3), CFLAR(2), CHUK(2), DFFB(2), FADD(1), GAS2(3), MAP3K14(1), NFKB1(2), RELA(3), SPTAN1(4), TNFRSF10A(1), TNFRSF10B(1), TRADD(1) 8861633 41 34 40 19 12 7 3 11 8 0 0.950 1.000 1.000 511 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(1), CARM1(1), CBS(4), GGT1(1), LCMT1(2), LCMT2(1), MARS(1), MAT1A(1), METTL2B(1), METTL6(2), PAPSS2(1), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), SCLY(1), SEPHS1(3), WBSCR22(3) 6596793 41 34 41 12 11 16 2 2 10 0 0.376 1.000 1.000 512 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(2), ACAD9(3), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), DHRS2(2), DHRSX(4), ESCO1(2), ESCO2(1), MYST3(11), MYST4(4), PNPLA3(1), SH3GLB1(1) 6626342 41 34 41 17 13 13 0 8 7 0 0.884 1.000 1.000 513 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(2), GALNT10(3), GALNT2(2), GALNT3(3), GALNT6(2), GALNT8(3), GALNT9(1), GCNT1(3), ST3GAL1(4), ST3GAL4(2), WBSCR17(12) 3817187 37 34 36 14 7 15 6 5 4 0 0.761 1.000 1.000 514 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), BIRC2(1), BIRC3(3), CASP8(2), CFLAR(2), FADD(1), JUN(3), MAP2K4(1), MAP3K3(1), MAP3K7(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), NFKBIL2(5), NR2C2(3), RALBP1(1), TNF(1), TNFAIP3(5), TNFRSF1A(2), TNFRSF1B(1), TRADD(1) 7209380 44 34 43 17 14 20 2 3 5 0 0.758 1.000 1.000 515 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 13 AKT1(1), EGFR(7), IGF1R(1), MYC(1), POLR2A(2), PRKCA(5), TEP1(8), TERF1(3), TERT(3), TNKS(7), XRCC5(2) 6807242 40 34 39 10 14 12 1 9 4 0 0.249 1.000 1.000 516 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(2), FBP2(1), GOT2(3), GPT(1), GPT2(4), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(2), PGK1(2), PKLR(4), PKM2(3), RPIA(2), TKT(1), TPI1(3) 4768734 36 33 36 16 8 12 2 7 7 0 0.829 1.000 1.000 517 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(10), GNAS(6), GNB1(1), PRKAA2(5), PRKAB2(1), PRKACB(3), PRKACG(1), PRKAG2(4), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3) 4039205 38 33 38 12 10 13 5 6 4 0 0.660 1.000 1.000 518 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(2), ACOT11(1), DHRS2(2), DHRSX(4), ECHS1(1), EHHADH(1), ESCO1(2), ESCO2(1), FN3K(1), GCDH(2), HADHA(2), MYST3(11), MYST4(4), PNPLA3(1), SH3GLB1(1) 6883700 36 33 36 19 10 9 1 9 7 0 0.981 1.000 1.000 519 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(2), ACP2(1), ACP6(2), ACPT(2), ENPP1(8), ENPP3(6), FLAD1(2), MTMR1(1), MTMR2(2), MTMR6(5), TYR(10) 3953309 41 33 41 12 5 19 4 4 9 0 0.532 1.000 1.000 520 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(9), BTRC(1), CTNNB1(4), DLL1(1), DVL1(2), FZD1(1), NOTCH1(18), PSEN1(3), WNT1(1) 5624290 40 33 40 13 7 15 1 6 11 0 0.659 1.000 1.000 521 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), FOS(2), HRAS(5), JUN(3), MAP2K1(2), MAPK1(1), MAPK3(1), MYC(1), NFKB1(2), PLCB1(8), PRKCA(5), RAF1(1), RELA(3), TNF(1) 4110222 37 32 35 15 12 13 4 6 2 0 0.821 1.000 1.000 522 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(10), ADRB2(4), CFTR(8), GNAS(6), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3) 3437821 39 32 39 12 13 13 3 7 3 0 0.564 1.000 1.000 523 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(1), APAF1(4), ATM(8), BAX(1), BCL2L1(1), CASP7(2), CASP9(3), PRKCA(5), PTK2(6), PXN(3), STAT1(2), TLN1(6) 7061111 42 32 41 13 16 12 4 8 2 0 0.682 1.000 1.000 524 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(2), KHK(2), LCT(18), MPI(1), PGM1(1), PYGL(3), PYGM(6), TPI1(3), TREH(1) 3554997 37 32 37 12 8 14 2 7 6 0 0.420 1.000 1.000 525 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(3), GNS(1), GUSB(2), HEXA(5), IDS(1), IDUA(2), LCT(18) 3778304 34 32 34 12 10 13 1 5 5 0 0.564 1.000 1.000 526 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), BCAT2(2), COASY(2), DPYD(9), DPYS(6), ENPP1(8), ENPP3(6), ILVBL(2), PANK1(1), PANK2(1), PANK3(1), PANK4(1), PPCS(1), VNN1(2) 4580363 43 32 43 14 10 16 4 4 9 0 0.618 1.000 1.000 527 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(1), CD2(1), CD3D(1), CD4(1), CXCR3(1), IFNG(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(4), JAK2(4), STAT4(5), TYK2(8) 3880627 34 32 34 11 8 12 2 5 7 0 0.654 1.000 1.000 528 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(1), CDK5R1(1), DAB1(6), FYN(5), RELN(34) 3715868 47 32 47 15 14 12 6 13 2 0 0.700 1.000 1.000 529 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(2), IKBKAP(4), IKBKB(2), LTA(2), MAP3K1(3), MAP3K14(1), NFKB1(2), RELA(3), TANK(4), TNFAIP3(5), TNFRSF1B(1), TRAF1(4), TRAF3(3) 5949035 36 32 36 12 3 10 3 11 9 0 0.722 1.000 1.000 530 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(2), ARHGEF1(2), GNA12(2), GNA13(1), GNB1(1), MYL2(2), MYLK(8), PLCB1(8), PPP1R12B(5), PRKCA(5), ROCK1(5) 5481718 41 31 41 13 15 14 3 6 3 0 0.691 1.000 1.000 531 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 14 AKT1(1), AKT3(3), CDKN1A(2), HRAS(5), MAP2K1(2), MAP2K2(1), NGFR(1), NTRK1(4), PIK3CD(4), SHC1(2), SOS1(11) 3704496 36 31 35 12 7 18 2 5 4 0 0.512 1.000 1.000 532 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(2), ACO2(3), DLD(2), DLST(1), FH(2), IDH1(2), IDH3A(1), IDH3B(4), IDH3G(2), MDH1(1), MDH2(1), PC(2), PCK1(3), SDHA(2), SDHB(2), SUCLA2(2), SUCLG2(1) 5454441 33 30 33 13 7 14 1 6 5 0 0.769 1.000 1.000 533 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(1), AMD1(1), BHMT(2), CBS(4), DNMT1(4), DNMT3A(7), DNMT3B(4), MARS(1), MAT1A(1), MTAP(1), MTR(8), TAT(1) 5477009 35 30 35 13 11 11 1 8 4 0 0.725 1.000 1.000 534 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(17), EP300(9), ESR1(6), MAPK1(1), MAPK3(1), PELP1(1) 3867990 35 30 34 11 4 13 2 12 4 0 0.626 1.000 1.000 535 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT2(1), B3GNT3(4), B3GNT4(1), B4GALT1(1), B4GALT3(3), B4GALT4(3), FUT2(1), FUT3(3), FUT5(4), FUT6(2), FUT9(5), GCNT2(2), ST3GAL6(2), ST8SIA1(3) 4260727 35 29 35 14 6 16 5 6 2 0 0.721 1.000 1.000 536 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(5), ATIC(1), FTCD(3), GART(3), MTHFD1(4), MTHFD1L(2), MTHFD2(4), MTHFR(2), MTR(8) 5021303 32 29 32 11 13 9 2 5 3 0 0.632 1.000 1.000 537 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 19 B2M(2), HLA-A(6), ITGB1(5), KLRC1(1), KLRC3(2), KLRD1(1), MAP2K1(2), MAPK3(1), PAK1(2), PIK3R1(2), RAC1(1), SYK(1), VAV1(7) 4341871 33 29 33 11 12 8 1 6 5 1 0.626 1.000 1.000 538 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM2(1), CAMK1G(3), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK4(3), HDAC5(1), MEF2A(2), MEF2C(4), MEF2D(3), PPARA(1), PPP3CA(4), PPP3CB(4), PPP3CC(2), SLC2A4(2), SYT1(4) 5349630 37 29 37 13 11 14 4 4 4 0 0.651 1.000 1.000 539 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 11 CREBBP(17), DAXX(3), HRAS(5), PAX3(4), RARA(1), SIRT1(1), SP100(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1) 4335370 38 29 37 10 7 15 4 9 3 0 0.381 1.000 1.000 540 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CASP2(1), CHUK(2), CRADD(1), IKBKB(2), JUN(3), LTA(2), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP3K1(3), MAP3K14(1), MAP4K2(1), MAPK14(1), MAPK8(3), NFKB1(2), RELA(3), TANK(4), TNF(1), TNFRSF1A(2), TRADD(1) 6394207 39 29 38 19 9 12 2 8 8 0 0.946 1.000 1.000 541 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 16 AKT1(1), CREB1(1), HRAS(5), MAPK1(1), MAPK3(1), MAPK7(1), MEF2A(2), MEF2C(4), MEF2D(3), NTRK1(4), PIK3R1(2), PLCG1(3), RPS6KA1(2), SHC1(2) 4442460 32 28 31 13 10 14 2 3 3 0 0.740 1.000 1.000 542 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(2), ACP2(1), ACP6(2), ACPT(2), ALPI(1), ALPL(3), ALPP(3), ALPPL2(1), CMBL(3), CYP3A4(1), CYP3A43(4), CYP3A7(1), DHRS2(2), DHRSX(4), PON1(7), PON2(1), PON3(1) 4754337 39 28 39 17 10 14 3 7 5 0 0.830 1.000 1.000 543 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(2), IL22(2), IL22RA1(1), IL22RA2(1), JAK1(2), JAK2(4), JAK3(7), SOCS3(1), STAT1(2), STAT3(2), STAT5A(2), TYK2(8) 4866410 34 28 34 11 9 14 2 4 5 0 0.436 1.000 1.000 544 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(11), MAP2(9), PPP1CA(1), PRKACB(3), PRKACG(1), PRKAR2B(3), PRKCE(3) 4825175 31 27 31 10 8 12 2 5 4 0 0.798 1.000 1.000 545 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(6), EGFR(7), MAP2K1(2), MAP3K1(3), MAPK14(1), NCOR2(7), RARA(1), RXRA(2), THRA(1), THRB(2) 4562313 32 27 31 14 6 14 0 9 3 0 0.858 1.000 1.000 546 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 10 DNM1(2), GABARAP(1), GABRA1(7), GABRA3(4), GABRA4(5), GABRA5(6), GPHN(2), NSF(2), UBQLN1(2) 2669600 31 27 31 10 5 12 4 6 4 0 0.681 1.000 1.000 547 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), BCAT2(2), IARS(3), IARS2(3), ILVBL(2), LARS(1), LARS2(3), PDHA1(3), PDHA2(8), VARS(5), VARS2(2) 4915355 33 27 33 11 7 15 2 6 3 0 0.619 1.000 1.000 548 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(1), BHMT(2), CBS(4), DNMT1(4), DNMT3A(7), DNMT3B(4), MARS(1), MAT1A(1), MTR(8) 4607304 32 27 32 12 9 11 1 8 3 0 0.730 1.000 1.000 549 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), CTSD(2), ESR1(6), GREB1(13), HSPB2(1), MTA1(1), MTA3(2), TUBA8(1) 2906466 27 27 27 15 2 13 2 9 1 0 0.951 1.000 1.000 550 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG5(2), B4GALT1(1), B4GALT3(3), B4GALT5(2), DDOST(1), DPM1(1), FUT8(2), MAN1A1(4), MGAT1(2), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT4B(1), MGAT5(6), RPN1(1), ST6GAL1(2) 5249675 36 27 36 17 12 16 2 4 2 0 0.872 1.000 1.000 551 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(5), ATIC(1), GART(3), MTHFD1(4), MTHFD1L(2), MTHFD2(4), MTHFR(2), MTR(8) 4751037 29 27 29 10 13 8 1 5 2 0 0.623 1.000 1.000 552 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), COASY(2), DPYD(9), DPYS(6), ENPP1(8), ENPP3(6), PANK1(1), PANK2(1), PANK3(1), PANK4(1), PPCS(1) 3688257 37 27 37 13 9 13 3 3 9 0 0.747 1.000 1.000 553 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 20 AKT1(1), BCL2L1(1), CASP9(3), CDC42(1), CHUK(2), H2AFX(1), HRAS(5), MAP2K1(2), MAPK3(1), NFKB1(2), PIK3R1(2), RAC1(1), RAF1(1), RALA(3), RALBP1(1), RALGDS(1), RELA(3) 4482297 31 27 29 11 11 8 2 7 3 0 0.691 1.000 1.000 554 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(4), BIRC2(1), BIRC3(3), CASP10(3), CASP7(2), CASP8(2), CASP9(3), DFFB(2), GZMB(1), PRF1(1), SCAP(4), SREBF1(2), SREBF2(3) 4815085 31 27 30 13 10 7 2 8 4 0 0.845 1.000 1.000 555 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(6), ESR2(2), ITPKA(1), PDE1A(2), PDE1B(3), PLCB1(8), PLCB2(5), PRL(1), VIP(1) 2937008 29 27 29 17 7 15 0 6 1 0 0.981 1.000 1.000 556 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT2(1), B3GNT7(1), B4GALT1(1), B4GALT3(3), B4GALT4(3), CHST1(3), CHST2(5), CHST4(2), CHST6(5), FUT8(2), ST3GAL1(4), ST3GAL4(2) 3311497 32 26 32 12 7 21 2 2 0 0 0.477 1.000 1.000 557 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 6 EPX(5), GBA(4), LPO(2), MPO(4), PRDX6(2), TPO(10) 1999864 27 26 27 10 7 10 4 6 0 0 0.637 1.000 1.000 558 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 RPL10L(7), RPL13(1), RPL14(1), RPL19(1), RPL28(1), RPL32(1), RPL37(1), RPL3L(2), RPL7(1), RPL8(2), RPS11(1), RPS12(1), RPS18(1), RPS2(1), RPS20(1), RPS21(1), RPS26(1), RPS6(1), RPS8(2) 6000808 28 26 28 16 11 8 0 7 2 0 0.951 1.000 1.000 559 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(3), CHUK(2), IFNG(1), IKBKB(2), IL4(2), JUN(3), MAP3K1(3), MAP3K5(4), MAP4K5(1), MAPK14(1), MAPK8(3), NFKB1(2), RELA(3), TNFRSF9(1) 5147145 31 25 30 11 10 8 2 7 4 0 0.773 1.000 1.000 560 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(4), AGT(1), AGTR1(5), AGTR2(3), BDKRB2(3), KNG1(9), NOS3(2) 2623263 27 25 27 11 5 12 2 4 4 0 0.699 1.000 1.000 561 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(6), IL4(2), MAF(1), MAP2K3(3), MAPK14(1), NFATC1(3), NFATC2(4), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3) 3178644 31 25 31 17 7 14 2 4 4 0 0.935 1.000 1.000 562 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(1), ASPH(4), COPS5(3), CREB1(1), EP300(9), HIF1A(1), JUN(3), NOS3(2), P4HB(5), VHL(1) 4490412 30 25 28 13 10 7 0 9 4 0 0.921 1.000 1.000 563 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(3), GPLD1(1), PGAP1(5), PIGB(1), PIGF(1), PIGG(4), PIGH(1), PIGK(1), PIGL(2), PIGN(1), PIGO(2), PIGQ(1), PIGT(1), PIGW(2), PIGX(1), PIGZ(2) 6353638 29 25 29 17 5 12 3 4 5 0 0.962 1.000 1.000 564 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(4), ARHGDIB(2), BIRC2(1), BIRC3(3), CASP1(1), CASP10(3), CASP2(1), CASP4(4), CASP7(2), CASP8(2), CASP9(3), DFFB(2), GZMB(1), PRF1(1) 5115374 30 24 29 14 9 5 1 8 7 0 0.953 1.000 1.000 565 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM2(1), CCR5(1), CXCR4(5), FOS(2), JUN(3), MAPK14(1), MAPK8(3), PLCG1(3), PRKCA(5), SYT1(4) 3642690 28 24 27 11 11 10 3 3 1 0 0.751 1.000 1.000 566 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(1), CASP8(2), FADD(1), MAP2K1(2), MAP2K4(1), MAP3K1(3), MAPK1(1), MAPK3(1), MAPK8(3), NFKB1(2), NSMAF(4), RAF1(1), RELA(3), SMPD1(4), TNFRSF1A(2), TRADD(1) 5437653 32 24 32 17 8 10 1 9 4 0 0.968 1.000 1.000 567 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 16 ADRB2(4), AKT1(1), ANXA1(1), CALM2(1), GNAS(6), GNB1(1), NFKB1(2), NOS3(2), NR3C1(1), PIK3R1(2), RELA(3), SYT1(4) 4149289 28 24 28 14 10 6 4 5 3 0 0.963 1.000 1.000 568 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), EPX(5), LPO(2), MPO(4), MTHFR(2), PRDX6(2), TPO(10) 3083778 26 24 26 12 8 10 3 5 0 0 0.834 1.000 1.000 569 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), EPX(5), LPO(2), MPO(4), PRDX1(1), PRDX6(2), TPO(10) 3125991 25 24 25 13 7 9 4 5 0 0 0.917 1.000 1.000 570 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(1), CREBBP(17), DFFB(2), GZMA(4), GZMB(1), HMGB2(1), PRF1(1) 2800041 27 24 27 10 5 10 2 6 4 0 0.739 1.000 1.000 571 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(3), HLA-DRA(1), HLA-DRB1(2), IFNG(1), IFNGR1(4), IFNGR2(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(4), IL18R1(2), IL4(2), IL4R(2) 3366449 29 24 29 10 12 7 0 4 6 0 0.742 1.000 1.000 572 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(3), ARPC1A(4), NCK1(2), NCKAP1(7), NTRK1(4), RAC1(1), WASF1(1), WASF3(1), WASL(2) 4043146 25 23 24 16 6 7 0 6 6 0 0.995 1.000 1.000 573 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(2), DHRSX(4), ESCO1(2), ESCO2(1), MYST3(11), MYST4(4), PNPLA3(1), SH3GLB1(1) 4387944 26 23 26 12 8 6 0 7 5 0 0.934 1.000 1.000 574 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BNIP1(2), GOSR1(1), SEC22B(4), SNAP23(1), SNAP25(1), STX10(1), STX11(2), STX16(1), STX19(2), STX2(1), STX5(2), STX7(1), TSNARE1(2), USE1(1), VAMP7(3), YKT6(1) 4401377 26 23 26 14 10 5 3 5 3 0 0.967 1.000 1.000 575 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), CREM(2), FOS(2), JUN(3), MAPK3(1), OPRK1(1), POLR2A(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3) 3395542 23 22 22 10 7 8 0 5 3 0 0.817 1.000 1.000 576 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(2), CYSLTR2(1), GPR109B(3), GPR161(2), GPR171(2), GPR18(2), GPR34(1), GPR39(2), GPR45(4), GPR65(3), GPR68(1), GPR75(2), GPR81(1) 2609365 26 22 26 12 8 9 0 8 1 0 0.714 1.000 1.000 577 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(2), MAP3K14(1), MAPK14(1), MAPK8(3), NFKB1(2), RELA(3), TNFRSF13B(2), TNFRSF17(1), TNFSF13(1), TRAF3(3), TRAF5(2), TRAF6(5) 3853892 26 22 26 10 6 7 1 5 7 0 0.816 1.000 1.000 578 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 14 AKT1(1), CREB1(1), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K6(2), MAP3K1(3), MAPK1(1), MAPK14(1), MAPK3(1), NFKB1(2), PIK3R1(2), RELA(3), SP1(2) 4087135 25 21 25 14 5 11 1 6 2 0 0.967 1.000 1.000 579 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 DHCR7(3), EBP(1), FDFT1(1), FDPS(1), GGPS1(2), HMGCR(1), HSD17B7(1), IDI1(1), IDI2(2), LSS(2), MVD(1), NSDHL(1), PMVK(1), SC5DL(1), SQLE(3), TM7SF2(1) 5112504 23 21 23 7 5 10 1 7 0 0 0.509 1.000 1.000 580 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(2), B3GAT2(2), CHPF(2), CHST11(2), CHST12(1), CHST3(2), CHSY1(2), DSE(4), UST(1), XYLT1(6) 3682842 24 21 24 13 3 9 1 8 3 0 0.928 1.000 1.000 581 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(3), POLR1B(2), POLR1D(1), POLR2A(2), POLR2B(6), POLR2D(1), POLR2E(2), POLR3A(1), POLR3B(1), POLR3G(1), POLR3H(2) 6225063 22 20 22 13 9 6 1 2 4 0 0.964 1.000 1.000 582 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(4), CD44(5), CSF1(2), FCGR3A(4), IL1B(1), IL6R(1), SELL(2), TGFB1(1), TGFB2(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF8(1) 3534805 28 20 28 11 7 10 2 5 4 0 0.779 1.000 1.000 583 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 12 AKT1(1), CHRNB1(1), CHRNG(4), MUSK(3), PIK3R1(2), PTK2(6), RAPSN(3), TERT(3) 3773899 23 19 23 15 12 8 0 1 2 0 0.953 1.000 1.000 584 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX15(3), ALOX15B(1), DPEP1(3), GGT1(1), LTA4H(2), PLA2G2A(1), PLA2G6(5), PTGES(1), PTGS1(2), PTGS2(1), TBXAS1(2) 3982745 22 19 22 9 4 14 1 3 0 0 0.625 1.000 1.000 585 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 17 AKT1(1), EIF2B5(3), EIF2S2(1), IGF1(3), IGF1R(1), INPPL1(4), PDK2(2), PDPK1(1), PIK3R1(2), RPS6(1), RPS6KB1(1) 4430426 20 19 20 10 8 6 2 0 4 0 0.908 1.000 1.000 586 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD3D(1), CD8A(2), ICAM1(2), ITGAL(1), ITGB2(5), PTPRC(7), THY1(2) 2844225 21 19 21 11 6 6 1 8 0 0 0.933 1.000 1.000 587 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD3D(1), CD4(1), ICAM1(2), ITGAL(1), ITGB2(5), PTPRC(7), THY1(2) 2987610 20 19 20 12 6 5 1 7 1 0 0.967 1.000 1.000 588 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(1), CDK5R1(1), EGR1(2), HRAS(5), KLK2(2), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), NGFR(1), RAF1(1) 2165029 18 18 17 7 5 9 1 3 0 0 0.581 1.000 1.000 589 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(3), APAF1(4), CASP9(3), DAXX(3), FAS(1), FASLG(1), HSPB2(1), IL1A(1), MAPKAPK2(1), MAPKAPK3(1), TNF(1) 2998501 20 18 19 15 8 5 1 4 2 0 0.997 1.000 1.000 590 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 12 ABL1(3), E2F1(2), MDM2(2), MYC(1), PIK3R1(2), POLR1A(3), POLR1B(2), POLR1D(1), RAC1(1), TBX2(3), TWIST1(1) 3958253 21 17 21 10 8 7 0 4 2 0 0.849 1.000 1.000 591 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(4), ARHGAP5(2), ARHGDIB(2), CASP1(1), CASP10(3), CASP8(2), CASP9(3), GZMB(1), JUN(3), PRF1(1) 3419095 22 17 20 11 10 2 1 5 4 0 0.961 1.000 1.000 592 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(2), FLT3(7), IGF1(3), IL1A(1), IL3(1), IL6(1), TGFB1(1), TGFB2(3) 2203477 19 17 19 11 6 7 1 5 0 0 0.959 1.000 1.000 593 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(4), ATF3(1), HBEGF(1), IFNG(1), IL1A(1), IL1R1(1), JUND(2), MYOG(1), NR4A3(3), WDR1(2) 2849921 17 17 17 11 5 7 1 0 4 0 0.989 1.000 1.000 594 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 13 AKT1(1), CASP9(3), CHUK(2), GH1(2), GHR(3), NFKB1(2), PDPK1(1), PIK3R1(2), RELA(3) 3157355 19 16 18 11 8 3 3 3 2 0 0.972 1.000 1.000 595 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(3), FDFT1(1), FDPS(1), HMGCR(1), HMGCS1(1), IDI1(1), LSS(2), MVD(1), NSDHL(1), PMVK(1), SC5DL(1), SQLE(3) 3497369 17 16 17 6 4 7 0 6 0 0 0.696 1.000 1.000 596 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(2), ACACB(9), FASN(2), MCAT(1), OLAH(2), OXSM(1) 4199649 17 15 17 14 8 5 1 1 2 0 0.990 1.000 1.000 597 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 ECHS1(1), EHHADH(1), HADH(1), HADHA(2), HSD17B4(1), SIRT1(1), SIRT2(3), SIRT7(2), VNN2(5) 3143630 17 15 17 10 2 6 1 4 4 0 0.969 1.000 1.000 598 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT1(1), B4GALT3(3), B4GALT5(2), FUT8(2), ST3GAL1(4), ST3GAL4(2) 2084891 14 14 14 10 4 7 1 2 0 0 0.973 1.000 1.000 599 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(2), BDH1(4), HMGCL(1), HMGCS1(1), HMGCS2(3), OXCT1(3) 1908433 14 12 14 7 6 5 0 3 0 0 0.907 1.000 1.000 600 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(3), B3GALT2(3), FUT2(1), FUT3(3), ST3GAL4(2) 1910628 12 12 12 6 5 3 2 2 0 0 0.856 1.000 1.000 601 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNB1(1), HTR2C(5), PLCB1(8) 1895707 14 12 14 8 4 7 1 2 0 0 0.927 1.000 1.000 602 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(5), AOC2(2), AOC3(3), CES1(2) 1596358 12 11 12 8 0 4 1 7 0 0 0.961 1.000 1.000 603 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(2), MYC(1), SP1(2), SP3(1), WT1(4) 1644721 10 10 10 5 1 3 2 4 0 0 0.902 1.000 1.000 604 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(3), LPL(3), NR3C1(1), RXRA(2), TNF(1) 1532756 10 10 10 6 3 5 0 2 0 0 0.897 1.000 1.000 605 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 MDH1(1), ME1(2), PC(2), PDHA1(3), SLC25A11(1) 2451814 9 9 9 10 3 2 0 2 2 0 0.995 1.000 1.000 606 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST2(2), HS3ST3A1(1), XYLT1(6) 1707422 9 8 9 6 1 6 0 2 0 0 0.865 1.000 1.000 607 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST2(2), HS3ST3A1(1), XYLT1(6) 1707422 9 8 9 6 1 6 0 2 0 0 0.865 1.000 1.000 608 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1), ALDOA(1), ALDOB(2), TPI1(3) 1032376 7 7 7 4 2 3 0 2 0 0 0.872 1.000 1.000 609 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(3), RAB11A(1), RAB4A(3) 1138299 7 7 7 13 1 5 0 0 1 0 1.000 1.000 1.000 610 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(2), HMGCL(1), OXCT1(3) 897227 6 6 6 3 0 3 0 3 0 0 0.894 1.000 1.000 611 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRNA1(4), SNAP25(1) 864662 5 5 5 3 3 1 0 1 0 0 0.829 1.000 1.000 612 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 5 GBA(4), GGT1(1) 1250013 5 5 5 5 1 2 1 1 0 0 0.968 1.000 1.000 613 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(1), NR1I3(1), PTGS1(2), PTGS2(1) 1415436 5 4 5 4 1 2 0 2 0 0 0.936 1.000 1.000 614 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ7(1), NDUFA13(2) 1066254 3 3 3 3 1 0 0 2 0 0 0.975 1.000 1.000 615 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 4 GGT1(1) 881202 1 1 1 4 0 1 0 0 0 0 0.997 1.000 1.000 616 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 405624 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000