Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.432 0.294 -9999.0 0.0 -0.692 228.0 228.0 IHH -0.47 0.384 -9999.0 0.0 -0.81 273.0 273.0 SHH Np/Cholesterol/GAS1 -0.07 0.165 -9999.0 0.0 -0.455 71.0 71.0 LRPAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.069 0.164 0.452 71.0 -9999.0 0.0 71.0 SMO/beta Arrestin2 -0.361 0.25 -9999.0 0.0 -0.592 236.0 236.0 SMO -0.38 0.271 -9999.0 0.0 -0.6 278.0 278.0 AKT1 -0.151 0.109 -9999.0 0.0 -0.34 1.0 1.0 ARRB2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.005 0.06 -9999.0 0.0 -0.656 4.0 4.0 ADRBK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.374 0.266 -9999.0 0.0 -0.589 278.0 278.0 STIL -0.327 0.247 -9999.0 0.0 -0.527 254.0 254.0 DHH N/PTCH2 -0.045 0.154 -9999.0 0.0 -0.562 39.0 39.0 DHH N/PTCH1 -0.363 0.243 -9999.0 0.0 -0.574 241.0 241.0 PIK3CA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.051 0.188 -9999.0 0.0 -0.739 34.0 34.0 PTHLH -0.581 0.356 -9999.0 0.0 -0.917 228.0 228.0 determination of left/right symmetry -0.374 0.266 -9999.0 0.0 -0.589 278.0 278.0 PIK3R1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.574 0.349 -9999.0 0.0 -0.904 228.0 228.0 IHH N/Hhip -0.653 0.377 -9999.0 0.0 -0.818 389.0 389.0 DHH N/Hhip -0.407 0.293 -9999.0 0.0 -0.594 335.0 335.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.374 0.266 -9999.0 0.0 -0.589 278.0 278.0 pancreas development -0.493 0.347 -9999.0 0.0 -0.738 327.0 327.0 HHAT 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.012 0.094 -9999.0 0.0 -0.739 8.0 8.0 somite specification -0.374 0.266 -9999.0 0.0 -0.589 278.0 278.0 SHH Np/Cholesterol/PTCH1 -0.35 0.25 -9999.0 0.0 -0.553 256.0 256.0 SHH Np/Cholesterol/PTCH2 -0.068 0.158 -9999.0 0.0 -0.443 69.0 69.0 SHH Np/Cholesterol/Megalin -0.287 0.268 -9999.0 0.0 -0.498 280.0 280.0 SHH -0.064 0.2 -9999.0 0.0 -0.544 72.0 72.0 catabolic process -0.372 0.252 -9999.0 0.0 -0.57 282.0 282.0 SMO/Vitamin D3 -0.37 0.265 -9999.0 0.0 -0.591 251.0 251.0 SHH Np/Cholesterol/Hhip -0.355 0.258 -9999.0 0.0 -0.501 345.0 345.0 LRP2 -0.379 0.369 -9999.0 0.0 -0.739 251.0 251.0 receptor-mediated endocytosis -0.498 0.311 -9999.0 0.0 -0.716 285.0 285.0 SHH Np/Cholesterol/BOC -0.066 0.158 -9999.0 0.0 -0.45 66.0 66.0 SHH Np/Cholesterol/CDO -0.067 0.156 -9999.0 0.0 -0.439 70.0 70.0 mesenchymal cell differentiation 0.352 0.256 0.497 345.0 -9999.0 0.0 345.0 mol:Vitamin D3 -0.349 0.259 -9999.0 0.0 -0.561 252.0 252.0 IHH N/PTCH2 -0.306 0.268 -9999.0 0.0 -0.539 273.0 273.0 CDON -0.008 0.074 -9999.0 0.0 -0.739 5.0 5.0 IHH N/PTCH1 -0.377 0.256 -9999.0 0.0 -0.578 282.0 282.0 Megalin/LRPAP1 -0.286 0.279 -9999.0 0.0 -0.557 251.0 251.0 PTCH2 -0.008 0.076 -9999.0 0.0 -0.683 6.0 6.0 SHH Np/Cholesterol -0.064 0.154 -9999.0 0.0 -0.434 72.0 72.0 PTCH1 -0.373 0.253 -9999.0 0.0 -0.572 282.0 282.0 HHIP -0.494 0.348 -9999.0 0.0 -0.739 327.0 327.0