Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling events mediated by the Hedgehog family	166.0	8679.0	52.0	-0.653	0.352	1000.0	-1000.0	-0.093	-1000.0
Angiopoietin receptor Tie2-mediated signaling	157.0	13894.0	88.0	-0.77	0.06	1000.0	-1000.0	-0.114	-1000.0
Aurora B signaling	132.0	8844.0	67.0	-0.621	0.005	1000.0	-1000.0	-0.08	-1000.0
FOXM1 transcription factor network	109.0	5577.0	51.0	-0.706	0.002	1000.0	-1000.0	-0.211	-1000.0
Aurora C signaling	100.0	704.0	7.0	-0.411	-0.0	1000.0	-1000.0	-0.045	-1000.0
Endothelins	77.0	7413.0	96.0	-0.448	0.038	1000.0	-1000.0	-0.105	-1000.0
Glypican 2 network	61.0	245.0	4.0	-0.085	-0.07	1000.0	-1000.0	-0.044	-1000.0
TCGA08_retinoblastoma	60.0	480.0	8.0	-0.278	0.085	1000.0	-1000.0	-0.029	-1000.0
amb2 Integrin signaling	59.0	4845.0	82.0	-0.683	0.0	1000.0	-1000.0	-0.099	-1000.0
Fc-epsilon receptor I signaling in mast cells	52.0	5047.0	97.0	-0.254	0.033	1000.0	-1000.0	-0.107	-1000.0
Thromboxane A2 receptor signaling	49.0	5169.0	105.0	-0.177	0.039	1000.0	-1000.0	-0.082	-1000.0
IL4-mediated signaling events	49.0	4500.0	91.0	-0.805	0.442	1000.0	-1000.0	-0.187	-1000.0
Glucocorticoid receptor regulatory network	46.0	5251.0	114.0	-0.559	0.367	1000.0	-1000.0	-0.093	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	46.0	2423.0	52.0	-0.382	0.057	1000.0	-1000.0	-0.078	-1000.0
Signaling events regulated by Ret tyrosine kinase	45.0	3690.0	82.0	-0.203	0.0	1000.0	-1000.0	-0.105	-1000.0
PLK1 signaling events	42.0	3587.0	85.0	-0.365	0.071	1000.0	-1000.0	-0.063	-1000.0
Visual signal transduction: Cones	39.0	1507.0	38.0	-0.281	0.009	1000.0	-1000.0	-0.072	-1000.0
BMP receptor signaling	39.0	3202.0	81.0	-0.387	0.033	1000.0	-1000.0	-0.102	-1000.0
Glypican 1 network	37.0	1799.0	48.0	-0.218	0.03	1000.0	-1000.0	-0.057	-1000.0
Nectin adhesion pathway	37.0	2343.0	63.0	-0.277	0.0	1000.0	-1000.0	-0.087	-1000.0
Arf6 signaling events	36.0	2278.0	62.0	-0.301	0.015	1000.0	-1000.0	-0.073	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	36.0	2814.0	78.0	-0.125	0.035	1000.0	-1000.0	-0.102	-1000.0
Signaling mediated by p38-alpha and p38-beta	34.0	1504.0	44.0	-0.129	0.0	1000.0	-1000.0	-0.064	-1000.0
Nongenotropic Androgen signaling	34.0	1780.0	52.0	-0.154	0.046	1000.0	-1000.0	-0.071	-1000.0
TCGA08_p53	33.0	234.0	7.0	-0.193	0.097	1000.0	-1000.0	-0.025	-1000.0
HIF-1-alpha transcription factor network	31.0	2416.0	76.0	-0.439	0.016	1000.0	-1000.0	-0.205	-1000.0
Integrins in angiogenesis	31.0	2615.0	84.0	-0.465	0.002	1000.0	-1000.0	-0.121	-1000.0
FOXA2 and FOXA3 transcription factor networks	28.0	1319.0	46.0	-0.782	0.073	1000.0	-1000.0	-0.131	-1000.0
Canonical Wnt signaling pathway	27.0	1398.0	51.0	-0.469	0.165	1000.0	-1000.0	-0.077	-1000.0
LPA4-mediated signaling events	26.0	314.0	12.0	-0.143	0.017	1000.0	-1000.0	-0.036	-1000.0
Coregulation of Androgen receptor activity	26.0	2047.0	76.0	-0.396	0.029	1000.0	-1000.0	-0.06	-1000.0
Syndecan-3-mediated signaling events	26.0	914.0	35.0	-0.341	0.0	1000.0	-1000.0	-0.084	-1000.0
IL23-mediated signaling events	26.0	1593.0	60.0	-0.243	0.018	1000.0	-1000.0	-0.187	-1000.0
IL6-mediated signaling events	25.0	1931.0	75.0	-0.474	0.05	1000.0	-1000.0	-0.106	-1000.0
Presenilin action in Notch and Wnt signaling	24.0	1522.0	61.0	-0.47	0.013	1000.0	-1000.0	-0.084	-1000.0
Reelin signaling pathway	24.0	1398.0	56.0	-0.13	0.003	1000.0	-1000.0	-0.1	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	24.0	1639.0	68.0	-0.228	0.015	1000.0	-1000.0	-0.177	-1000.0
ErbB4 signaling events	23.0	1606.0	69.0	-0.386	0.198	1000.0	-1000.0	-0.098	-1000.0
Regulation of Androgen receptor activity	22.0	1541.0	70.0	-0.415	0.018	1000.0	-1000.0	-0.085	-1000.0
Syndecan-1-mediated signaling events	21.0	746.0	34.0	-0.354	0.0	1000.0	-1000.0	-0.075	-1000.0
Aurora A signaling	21.0	1295.0	60.0	-0.486	0.029	1000.0	-1000.0	-0.064	-1000.0
Calcium signaling in the CD4+ TCR pathway	21.0	669.0	31.0	-0.212	0.012	1000.0	-1000.0	-0.151	-1000.0
Visual signal transduction: Rods	21.0	1117.0	52.0	-0.176	0.0	1000.0	-1000.0	-0.098	-1000.0
IL12-mediated signaling events	20.0	1777.0	87.0	-0.154	0.017	1000.0	-1000.0	-0.148	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	20.0	2593.0	125.0	-0.207	0.0	1000.0	-1000.0	-0.123	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	20.0	661.0	33.0	-0.269	0.0	1000.0	-1000.0	-0.073	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	19.0	1046.0	54.0	-0.147	0.02	1000.0	-1000.0	-0.111	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	19.0	2299.0	120.0	-0.27	0.127	1000.0	-1000.0	-0.1	-1000.0
Osteopontin-mediated events	18.0	697.0	38.0	-0.296	0.0	1000.0	-1000.0	-0.133	-1000.0
Wnt signaling	18.0	127.0	7.0	-0.095	0.0	1000.0	-1000.0	-0.061	-1000.0
Plasma membrane estrogen receptor signaling	18.0	1559.0	86.0	-0.177	0.032	1000.0	-1000.0	-0.097	-1000.0
HIF-2-alpha transcription factor network	17.0	773.0	43.0	-0.373	0.203	1000.0	-1000.0	-0.109	-1000.0
TCR signaling in naïve CD8+ T cells	16.0	1520.0	93.0	-0.063	0.036	1000.0	-1000.0	-0.1	-1000.0
p75(NTR)-mediated signaling	15.0	1931.0	125.0	-0.344	0.0	1000.0	-1000.0	-0.117	-1000.0
PDGFR-alpha signaling pathway	15.0	665.0	44.0	-0.207	0.014	1000.0	-1000.0	-0.081	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	14.0	1207.0	85.0	-0.154	0.01	1000.0	-1000.0	-0.089	-1000.0
Ephrin A  reverse signaling	13.0	91.0	7.0	-0.023	0.003	1000.0	-1000.0	-0.043	-1000.0
EGFR-dependent Endothelin signaling events	12.0	264.0	21.0	-0.063	0.0	1000.0	-1000.0	-0.085	-1000.0
Caspase cascade in apoptosis	11.0	861.0	74.0	-0.069	0.035	1000.0	-1000.0	-0.068	-1000.0
Regulation of nuclear SMAD2/3 signaling	11.0	1516.0	136.0	-0.33	0.093	1000.0	-1000.0	-0.095	-1000.0
JNK signaling in the CD4+ TCR pathway	11.0	194.0	17.0	-0.039	0.023	1000.0	-1000.0	-0.073	-1000.0
FAS signaling pathway (CD95)	11.0	552.0	47.0	-0.197	0.009	1000.0	-1000.0	-0.056	-1000.0
Noncanonical Wnt signaling pathway	10.0	269.0	26.0	-0.101	0.0	1000.0	-1000.0	-0.1	-1000.0
Syndecan-2-mediated signaling events	10.0	702.0	69.0	-0.167	0.033	1000.0	-1000.0	-0.075	-1000.0
Effects of Botulinum toxin	10.0	271.0	26.0	-0.074	0.005	1000.0	-1000.0	-0.072	-1000.0
Ras signaling in the CD4+ TCR pathway	10.0	184.0	17.0	-0.054	0.008	1000.0	-1000.0	-0.075	-1000.0
S1P1 pathway	9.0	359.0	36.0	-0.061	0.01	1000.0	-1000.0	-0.093	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	9.0	702.0	74.0	-0.17	0.068	1000.0	-1000.0	-0.096	-1000.0
BCR signaling pathway	9.0	946.0	99.0	-0.108	0.039	1000.0	-1000.0	-0.112	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	8.0	305.0	34.0	-0.028	0.0	1000.0	-1000.0	-0.074	-1000.0
Hedgehog signaling events mediated by Gli proteins	8.0	576.0	65.0	-0.6	0.043	1000.0	-1000.0	-0.087	-1000.0
IL2 signaling events mediated by STAT5	8.0	177.0	22.0	-0.147	0.059	1000.0	-1000.0	-0.066	-1000.0
Syndecan-4-mediated signaling events	8.0	595.0	67.0	-0.167	0.009	1000.0	-1000.0	-0.114	-1000.0
S1P4 pathway	8.0	218.0	25.0	-0.066	0.002	1000.0	-1000.0	-0.067	-1000.0
Signaling events mediated by PTP1B	7.0	535.0	76.0	-0.101	0.033	1000.0	-1000.0	-0.094	-1000.0
Signaling events mediated by HDAC Class III	7.0	293.0	40.0	-0.15	0.051	1000.0	-1000.0	-0.051	-1000.0
TRAIL signaling pathway	7.0	351.0	48.0	-0.097	0.046	1000.0	-1000.0	-0.079	-1000.0
Sphingosine 1-phosphate (S1P) pathway	6.0	187.0	28.0	-0.177	0.02	1000.0	-1000.0	-0.066	-1000.0
Cellular roles of Anthrax toxin	6.0	257.0	39.0	-0.09	0.017	1000.0	-1000.0	-0.034	-1000.0
Retinoic acid receptors-mediated signaling	6.0	369.0	58.0	-0.22	0.034	1000.0	-1000.0	-0.094	-1000.0
Regulation of p38-alpha and p38-beta	6.0	326.0	54.0	-0.095	0.037	1000.0	-1000.0	-0.086	-1000.0
IL27-mediated signaling events	6.0	307.0	51.0	-0.123	0.011	1000.0	-1000.0	-0.092	-1000.0
S1P3 pathway	6.0	257.0	42.0	-0.177	0.042	1000.0	-1000.0	-0.067	-1000.0
Signaling events mediated by PRL	6.0	209.0	34.0	-0.126	0.029	1000.0	-1000.0	-0.069	-1000.0
BARD1 signaling events	5.0	288.0	57.0	-0.126	0.022	1000.0	-1000.0	-0.084	-1000.0
IL1-mediated signaling events	5.0	328.0	62.0	-0.058	0.042	1000.0	-1000.0	-0.121	-1000.0
IL2 signaling events mediated by PI3K	5.0	300.0	58.0	-0.225	0.073	1000.0	-1000.0	-0.098	-1000.0
LPA receptor mediated events	5.0	597.0	102.0	-0.1	0.034	1000.0	-1000.0	-0.104	-1000.0
IGF1 pathway	5.0	291.0	57.0	-0.02	0.04	1000.0	-1000.0	-0.129	-1000.0
Insulin Pathway	5.0	442.0	74.0	-0.104	0.031	1000.0	-1000.0	-0.114	-1000.0
ErbB2/ErbB3 signaling events	4.0	287.0	65.0	-0.077	0.054	1000.0	-1000.0	-0.084	-1000.0
Signaling events mediated by HDAC Class II	4.0	328.0	75.0	-0.079	0.0	1000.0	-1000.0	-0.073	-1000.0
Ephrin B reverse signaling	4.0	212.0	48.0	-0.07	0.04	1000.0	-1000.0	-0.079	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	4.0	362.0	83.0	-0.07	0.049	1000.0	-1000.0	-0.093	-1000.0
Signaling events mediated by HDAC Class I	4.0	442.0	104.0	-0.079	0.041	1000.0	-1000.0	-0.079	-1000.0
Arf6 trafficking events	4.0	301.0	71.0	-0.087	0.032	1000.0	-1000.0	-0.077	-1000.0
a4b1 and a4b7 Integrin signaling	3.0	17.0	5.0	-0.008	-0.002	1000.0	-1000.0	-0.048	-1000.0
IFN-gamma pathway	3.0	250.0	68.0	-0.068	0.065	1000.0	-1000.0	-0.11	-1000.0
EPHB forward signaling	3.0	313.0	85.0	-0.07	0.032	1000.0	-1000.0	-0.111	-1000.0
TCGA08_rtk_signaling	3.0	79.0	26.0	-0.066	0.038	1000.0	-1000.0	-0.038	-1000.0
Class I PI3K signaling events	3.0	270.0	73.0	-0.05	0.026	1000.0	-1000.0	-0.084	-1000.0
Regulation of Telomerase	3.0	405.0	102.0	-0.116	0.025	1000.0	-1000.0	-0.11	-1000.0
VEGFR1 specific signals	3.0	212.0	56.0	-0.207	0.044	1000.0	-1000.0	-0.087	-1000.0
p38 MAPK signaling pathway	3.0	159.0	44.0	-0.068	0.034	1000.0	-1000.0	-0.08	-1000.0
Circadian rhythm pathway	2.0	56.0	22.0	-0.03	0.038	1000.0	-1000.0	-0.07	-1000.0
Ceramide signaling pathway	2.0	182.0	76.0	-0.025	0.04	1000.0	-1000.0	-0.078	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	90.0	37.0	-0.01	0.027	1000.0	-1000.0	-0.09	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	116.0	45.0	-0.027	0.061	1000.0	-1000.0	-0.109	-1000.0
PDGFR-beta signaling pathway	2.0	216.0	97.0	-0.04	0.054	1000.0	-1000.0	-0.103	-1000.0
E-cadherin signaling in keratinocytes	2.0	91.0	43.0	-0.022	0.042	1000.0	-1000.0	-0.087	-1000.0
Class IB PI3K non-lipid kinase events	2.0	6.0	3.0	-0.003	-1000.0	1000.0	-1000.0	-0.034	-1000.0
PLK2 and PLK4 events	1.0	4.0	3.0	-0.002	0.018	1000.0	-1000.0	-0.028	-1000.0
EPO signaling pathway	1.0	62.0	55.0	-0.008	0.065	1000.0	-1000.0	-0.111	-1000.0
Insulin-mediated glucose transport	1.0	52.0	32.0	-0.057	0.034	1000.0	-1000.0	-0.066	-1000.0
S1P5 pathway	1.0	26.0	17.0	-0.01	0.006	1000.0	-1000.0	-0.066	-1000.0
FoxO family signaling	1.0	95.0	64.0	-0.089	0.08	1000.0	-1000.0	-0.103	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	15.0	15.0	-0.001	0.027	1000.0	-1000.0	-0.06	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	65.0	36.0	-0.008	0.02	1000.0	-1000.0	-0.074	-1000.0
Rapid glucocorticoid signaling	1.0	35.0	20.0	-0.008	0.007	1000.0	-1000.0	-0.043	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	0.0	23.0	0.0	0.036	1000.0	-1000.0	-0.075	-1000.0
Canonical NF-kappaB pathway	0.0	33.0	39.0	-0.019	0.071	1000.0	-1000.0	-0.1	-1000.0
Arf6 downstream pathway	0.0	19.0	43.0	-0.024	0.025	1000.0	-1000.0	-0.046	-1000.0
mTOR signaling pathway	0.0	7.0	53.0	-0.003	0.03	1000.0	-1000.0	-0.072	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	57.0	68.0	-0.057	0.043	1000.0	-1000.0	-0.075	-1000.0
ceramide signaling pathway	0.0	45.0	49.0	-0.013	0.043	1000.0	-1000.0	-0.065	-1000.0
Atypical NF-kappaB pathway	0.0	9.0	31.0	-0.002	0.03	1000.0	-1000.0	-0.085	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	50.0	76.0	-0.023	0.053	1000.0	-1000.0	-0.095	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	1.0	27.0	-0.001	0.025	1000.0	-1000.0	-0.066	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.0	0.0	1000.0	-1000.0	-0.047	-1000.0
Arf1 pathway	0.0	48.0	54.0	-0.023	0.022	1000.0	-1000.0	-0.05	-1000.0
Alternative NF-kappaB pathway	0.0	4.0	13.0	-0.001	0.0	1000.0	-1000.0	-0.079	-1000.0
Total	2590	159884	7203	-24.9077794506	-994.758067922	131000	-131000	-11.4364154165	-131000