E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.009 0.09 -9999.0 0.0 -0.338 26.0 26.0 KLHL20 0.016 0.058 0.174 1.0 -0.249 9.0 10.0 CYFIP2 0.009 0.082 -9999.0 0.0 -0.557 10.0 10.0 Rac1/GDP 0.013 0.07 0.252 2.0 -9999.0 0.0 2.0 ENAH -0.009 0.095 -9999.0 0.0 -0.338 29.0 29.0 AP1M1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.014 0.029 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.01 0.036 -9999.0 0.0 -0.186 11.0 11.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.051 0.026 -9999.0 0.0 -0.327 1.0 1.0 RAPGEF1 -0.004 0.08 -9999.0 0.0 -0.324 1.0 1.0 CTNND1 0.023 0.001 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.005 0.098 -9999.0 0.0 -0.343 30.0 30.0 CRK -0.004 0.072 -9999.0 0.0 -0.324 12.0 12.0 E-cadherin/gamma catenin/alpha catenin 0.043 0.014 -9999.0 0.0 -9999.0 0.0 0.0 alphaE/beta7 Integrin 0.031 0.022 -9999.0 0.0 -0.412 1.0 1.0 IQGAP1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.04 0.014 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.001 0.064 -9999.0 0.0 -0.336 14.0 14.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.008 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.041 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.009 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 0.021 0.027 -9999.0 0.0 -0.557 1.0 1.0 E-cadherin(dimer)/Ca2+ 0.049 0.017 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.005 0.031 0.122 2.0 -9999.0 0.0 2.0 PIK3R1 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.017 0.065 0.252 2.0 -9999.0 0.0 2.0 actin cytoskeleton organization 0.015 0.046 0.152 5.0 -0.183 8.0 13.0 CDC42/GDP 0.016 0.068 0.252 2.0 -9999.0 0.0 2.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.014 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ITGB7 0.022 0.026 -9999.0 0.0 -0.557 1.0 1.0 RAC1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.053 0.019 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.037 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.002 0.074 0.26 2.0 -0.309 1.0 3.0 CDC42/GTP/IQGAP1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.023 0.064 0.271 1.0 -9999.0 0.0 1.0 RAC1/GTP/IQGAP1 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.009 0.04 0.139 4.0 -0.239 6.0 10.0 NME1 0.023 0.01 0.236 1.0 -9999.0 0.0 1.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.006 0.091 -9999.0 0.0 -0.337 26.0 26.0 regulation of cell-cell adhesion 0.009 0.024 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.008 0.025 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.018 0.04 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.06 0.028 -9999.0 0.0 -0.311 1.0 1.0 CCND1 0.01 0.048 0.158 4.0 -0.302 6.0 10.0 VAV2 -0.011 0.122 -9999.0 0.0 -0.64 9.0 9.0 RAP1/GDP 0.02 0.055 0.246 1.0 -9999.0 0.0 1.0 adherens junction assembly -0.007 0.089 -9999.0 0.0 -0.326 28.0 28.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.044 0.026 -9999.0 0.0 -0.302 1.0 1.0 E-cadherin/beta catenin 0.01 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.008 0.092 -9999.0 0.0 -0.337 26.0 26.0 PIK3CA 0.012 0.012 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.013 0.077 -9999.0 0.0 -0.415 10.0 10.0 E-cadherin/beta catenin/alpha catenin 0.042 0.015 -9999.0 0.0 -9999.0 0.0 0.0 ITGAE 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.006 0.1 -9999.0 0.0 -0.35 30.0 30.0