Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.159 0.232 -9999.0 0.0 -0.75 28.0 28.0 IHH -0.305 0.311 -9999.0 0.0 -0.591 262.0 262.0 SHH Np/Cholesterol/GAS1 -0.029 0.121 0.196 1.0 -0.326 67.0 68.0 LRPAP1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.029 0.12 0.324 67.0 -0.194 1.0 68.0 SMO/beta Arrestin2 -0.203 0.225 -9999.0 0.0 -0.397 256.0 256.0 SMO -0.218 0.228 -9999.0 0.0 -0.413 260.0 260.0 AKT1 -0.109 0.156 -9999.0 0.0 -0.583 29.0 29.0 ARRB2 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.019 0.04 0.236 2.0 -0.557 2.0 4.0 ADRBK1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.215 0.225 -9999.0 0.0 -0.408 260.0 260.0 STIL -0.174 0.186 0.237 1.0 -0.462 76.0 77.0 DHH N/PTCH2 0.0 0.118 -9999.0 0.0 -0.408 36.0 36.0 DHH N/PTCH1 -0.18 0.206 -9999.0 0.0 -0.333 292.0 292.0 PIK3CA 0.012 0.012 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.022 0.147 -9999.0 0.0 -0.557 34.0 34.0 PTHLH -0.197 0.262 -9999.0 0.0 -0.753 27.0 27.0 determination of left/right symmetry -0.215 0.225 -9999.0 0.0 -0.408 260.0 260.0 PIK3R1 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.196 0.26 -9999.0 0.0 -0.745 27.0 27.0 IHH N/Hhip -0.438 0.286 -9999.0 0.0 -0.567 382.0 382.0 DHH N/Hhip -0.275 0.228 -9999.0 0.0 -0.418 332.0 332.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.215 0.225 -9999.0 0.0 -0.408 260.0 260.0 pancreas development -0.336 0.279 -9999.0 0.0 -0.556 299.0 299.0 HHAT 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.017 0.017 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.014 0.069 -9999.0 0.0 -0.557 7.0 7.0 somite specification -0.215 0.225 -9999.0 0.0 -0.408 260.0 260.0 SHH Np/Cholesterol/PTCH1 -0.178 0.196 -9999.0 0.0 -0.323 281.0 281.0 SHH Np/Cholesterol/PTCH2 -0.026 0.117 0.196 1.0 -0.323 63.0 64.0 SHH Np/Cholesterol/Megalin -0.19 0.2 -9999.0 0.0 -0.361 263.0 263.0 SHH -0.06 0.133 0.296 1.0 -0.413 60.0 61.0 catabolic process -0.18 0.209 -9999.0 0.0 -0.353 275.0 275.0 SMO/Vitamin D3 -0.203 0.222 -9999.0 0.0 -0.381 257.0 257.0 SHH Np/Cholesterol/Hhip -0.232 0.193 -9999.0 0.0 -0.364 307.0 307.0 LRP2 -0.27 0.289 -9999.0 0.0 -0.557 245.0 245.0 receptor-mediated endocytosis -0.316 0.261 -9999.0 0.0 -0.578 203.0 203.0 SHH Np/Cholesterol/BOC -0.023 0.109 -9999.0 0.0 -0.326 53.0 53.0 SHH Np/Cholesterol/CDO -0.027 0.118 0.196 1.0 -0.323 65.0 66.0 mesenchymal cell differentiation 0.23 0.192 0.361 307.0 -9999.0 0.0 307.0 mol:Vitamin D3 -0.175 0.202 0.245 1.0 -0.395 130.0 131.0 IHH N/PTCH2 -0.186 0.205 -9999.0 0.0 -0.37 263.0 263.0 CDON 0.016 0.059 -9999.0 0.0 -0.557 5.0 5.0 IHH N/PTCH1 -0.174 0.221 -9999.0 0.0 -0.357 275.0 275.0 Megalin/LRPAP1 -0.19 0.22 -9999.0 0.0 -0.41 243.0 243.0 PTCH2 0.02 0.048 0.236 2.0 -0.557 3.0 5.0 SHH Np/Cholesterol -0.033 0.109 -9999.0 0.0 -0.32 60.0 60.0 PTCH1 -0.181 0.21 -9999.0 0.0 -0.354 275.0 275.0 HHIP -0.336 0.279 -9999.0 0.0 -0.557 299.0 299.0