Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.018 0.006 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.044 0.016 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.009 0.082 -9999.0 0.0 -0.557 10.0 10.0 ENAH 0.006 0.068 0.26 12.0 -9999.0 0.0 12.0 EGFR 0.022 0.083 0.361 11.0 -0.557 6.0 17.0 EPHA2 0.018 0.046 -9999.0 0.0 -0.557 3.0 3.0 MYO6 -0.009 0.028 0.345 1.0 -9999.0 0.0 1.0 CTNNB1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.033 0.056 -9999.0 0.0 -0.355 8.0 8.0 AQP5 -0.138 0.225 -9999.0 0.0 -0.482 143.0 143.0 CTNND1 0.023 0.001 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.01 0.026 0.343 1.0 -9999.0 0.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.085 0.127 0.343 1.0 -0.292 127.0 128.0 EGF 0.015 0.071 0.236 3.0 -0.557 7.0 10.0 NCKAP1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.061 0.167 -9999.0 0.0 -0.474 66.0 66.0 cortical microtubule organization 0.044 0.016 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 -0.01 0.024 0.333 1.0 -9999.0 0.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.049 0.017 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.02 0.023 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.043 0.039 -9999.0 0.0 -0.327 3.0 3.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.002 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.01 0.022 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.046 0.04 -9999.0 0.0 -0.307 3.0 3.0 CDH1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF 0.031 0.061 -9999.0 0.0 -0.315 12.0 12.0 RhoA/GDP 0.045 0.017 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.012 0.019 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.004 0.104 0.236 1.0 -0.557 16.0 17.0 DIAPH1 -0.013 0.162 -9999.0 0.0 -0.589 16.0 16.0 Wnt receptor signaling pathway -0.044 0.016 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.02 0.023 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.012 0.019 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.008 0.021 0.338 1.0 -9999.0 0.0 1.0 Ephrin A1/EPHA2 0.036 0.031 -9999.0 0.0 -0.293 3.0 3.0 SEC6/SEC8 -0.016 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.086 0.129 0.345 1.0 -0.297 127.0 128.0 HGF/MET -0.024 0.129 -9999.0 0.0 -0.29 83.0 83.0 HGF -0.09 0.229 -9999.0 0.0 -0.557 94.0 94.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.018 0.006 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.047 0.104 0.326 27.0 -9999.0 0.0 27.0 KIAA1543 -0.01 0.023 0.335 1.0 -9999.0 0.0 1.0 KIFC3 -0.011 0.026 0.345 1.0 -9999.0 0.0 1.0 NCK1 0.019 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.018 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.01 0.027 0.345 1.0 -9999.0 0.0 1.0 NCK1/GIT1 0.028 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.044 0.016 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.01 0.027 0.345 1.0 -9999.0 0.0 1.0 PIP5K1C -0.01 0.026 0.345 1.0 -9999.0 0.0 1.0 LIMA1 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.015 0.086 0.306 18.0 -9999.0 0.0 18.0 adherens junction assembly -0.014 0.093 0.313 3.0 -0.71 6.0 9.0 IGF-1R heterotetramer/IGF1 0.029 0.058 -9999.0 0.0 -0.293 13.0 13.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.02 0.041 0.373 1.0 -0.557 2.0 3.0 PLEKHA7 -0.01 0.025 0.345 1.0 -9999.0 0.0 1.0 mol:GTP 0.042 0.038 -9999.0 0.0 -0.325 3.0 3.0 establishment of epithelial cell apical/basal polarity 0.025 0.089 0.375 9.0 -9999.0 0.0 9.0 cortical actin cytoskeleton stabilization 0.018 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion -0.012 0.019 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.018 0.006 -9999.0 0.0 -9999.0 0.0 0.0